{"ymdb_id":"YMDB00721","created_at":"2011-05-29T18:46:35.000Z","updated_at":"2016-09-08T18:35:49.000Z","name":"L-Allysine","cas":"1962-83-0","state":"Solid","melting_point":null,"description":"Allysine is a derivative of lysine, used in the production of elastin and collagen. It is produced by the actions of the enzyme lysyl oxidase in the extracellular matrix and is essential in the crosslink formation that stabilizes collagen and elastin.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"17917","hmdb_id":"HMDB01263","kegg_id":"C04076","pubchem_id":"36688062","cs_id":"141126","foodb_id":null,"wikipedia_link":"Allysine","biocyc_id":"ALLYSINE","iupac":"(2S)-2-amino-6-oxohexanoic acid","traditional_iupac":"2-amino-6-oxo-hexanoic acid","logp":"-2.9081307009163337","pka":"17.588756721963396","alogps_solubility":"4.94e+01 g/l","alogps_logp":"-2.20","alogps_logs":"-0.47","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"5","polar_surface_area":"80.39000000000001","refractivity":"34.963300000000004","polarizability":"14.583357065587663","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.326170574223008","pka_strongest_acidic":"2.249930329891744","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2S)-2-amino-6-oxohexanoate","(2S)-2-amino-6-oxohexanoic acid","(S)-2-Amino-6-oxohexanoate","(S)-2-aminoadipate 6-semialdehyde","2-Amino-5-formylvalerate","2-Amino-5-formylvaleric acid","2-AMINO-6-OXO-HEXANOIC ACID","2-amino-hexanedioate","2-amino-hexanedioic acid","2-amino-hexanedioic acid semialdhyde","2-aminoadipate 6-semialdehyde","2-aminoadipate semialdehyde","2-aminoadipate-6-semialdehyde","5-formyl-Norvaline","6-oxo-L-norleucine","6-oxo-Norleucine","Allysine","alpha-aminoadipate 6-semialdehyde","alpha-Aminoadipic acid delta-semialdehyde","alpha-Aminoadipic delta-semialdehyde","alpha-Aminoadipic semialdehyde","L-2-Aminoadipate 6-semialdehyde","L-6-oxonorleucine"],"pathways":[{"name":"Lysine degradation","kegg_map_id":"00310"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"lysine metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":3123231,"citation":"Ramos, F., Dubois, E., Pierard, A. (1988). \"Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14.\" Eur J Biochem 171:171-176."},{"pubmed_id":3928261,"citation":"Bhattacharjee, J. K. (1985). \"alpha-Aminoadipate pathway for the biosynthesis of lysine in lower eukaryotes.\" Crit Rev Microbiol 12:131-151."}],"proteins":[{"created_at":"2011-05-24T20:18:23.000Z","updated_at":"2011-05-27T14:56:00.000Z","name":"Saccharopine dehydrogenase [NADP+, L-glutamate-forming]","uniprot_id":"P38999","uniprot_name":"LYS9_YEAST","enzyme":true,"transporter":false,"gene_name":"LYS9","num_residues":446,"molecular_weight":"48917.30078","theoretical_pi":"4.87","general_function":"Involved in binding","specific_function":"N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-glutamate + L-2-aminoadipate 6-semialdehyde + NADPH","reactions":[{"id":1960,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2310,"direction":"\u003e","locations":null,"altext":"N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-glutamate + L-2-aminoadipate 6-semialdehyde + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":4178,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006477","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X77363","genbank_protein_id":"453186","gene_card_id":"LYS9","chromosome_location":"chromosome 14","locus":"YNR050C","synonyms":["Saccharopine reductase"],"enzyme_classes":["1.5.1.10"],"go_classes":[],"pfams":[{"name":"Saccharop_dh","identifier":"PF03435"}],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Lysine degradation","kegg_map_id":"00310"},{"name":"lysine metabolism","kegg_map_id":null}],"gene_sequence":"ATGGGAAAGAACGTTTTGTTGCTAGGATCTGGTTTTGTTGCACAACCTGTTATCGACACATTGGCTGCTAATGATGACATCAATGTCACTGTCGCATGTAGAACATTAGCCAATGCGCAAGCATTGGCCAAGCCCTCTGGATCCAAGGCTATTTCATTGGATGTTACCGATGACAGTGCCTTAGACAAAGTTCTGGCTGATAACGATGTTGTCATCTCTTTGATTCCATACACCTTCCATCCAAATGTGGTAAAGAGCGCCATCAGAACAAAGACCGATGTCGTCACTTCCTCTTACATCTCACCTGCCTTAAGAGAATTGGAACCAGAAATCGTAAAGGCAGGTATTACAGTTATGAACGAAATTGGGTTGGATCCAGGTATCGACCACTTGTATGCGGTCAAGACTATTGATGAAGTTCACAGAGCTGGTGGTAAGCTAAAGTCATTCTTGTCATACTGTGGTGGTTTACCAGCTCCTGAAGACTCTGATAATCCATTAGGATACAAATTTTCATGGTCCTCCAGAGGTGTGCTACTGGCTTTAAGAAACTCTGCTAAATACTGGAAAGACGGAAAGATTGAAACTGTTTCTTCCGAAGACTTAATGGCCACTGCTAAGCCTTACTTCATCTACCCAGGTTATGCATTCGTTTGCTACCCAAATAGAGACTCTACCCTTTTCAAGGATCTTTATCATATTCCAGAAGCCGAAACGGTCATTAGAGGTACTTTGAGATATCAAGGTTTCCCAGAATTTGTTAAGGCTTTAGTTGACATGGGTATGTTGAAGGATGATGCTAACGAAATCTTCAGCAAGCCAATTGCCTGGAACGAAGCACTAAAACAATATTTAGGTGCCAAGTCTACTTCTAAAGAAGATTTGATTGCTTCCATTGACTCAAAGGCTACTTGGAAAGATGATGAAGATAGAGAAAGAATCCTTTCCGGGTTTGCTTGGTTAGGCTTGTTCTCTGACGCAAAGATCACACCAAGAGGTAATGCTTTAGACACTCTATGTGCACGTTTAGAAGAACTAATGCAATATGAAGACAATGAAAGAGATATGGTTGTACTACAACACAAATTCGGTATTGAATGGGCTGATGGAACTACCGAAACAAGAACATCCACTTTAGTTGACTATGGTAAGGTTGGTGGTTACAGTTCTATGGCCGCTACTGTTGGTTATCCAGTTGCCATTGCAACGAAATTCGTCTTAGATGGTACAATCAAGGGACCAGGCTTACTAGCGCCATACTCACCAGAGATTAATGATCCAATCATGAAAGAACTAAAGGACAAGTACGGCATCTATCTAAAGGAAAAGACAGTGGCTTAA","protein_sequence":"MGKNVLLLGSGFVAQPVIDTLAANDDINVTVACRTLANAQALAKPSGSKAISLDVTDDSALDKVLADNDVVISLIPYTFHPNVVKSAIRTKTDVVTSSYISPALRELEPEIVKAGITVMNEIGLDPGIDHLYAVKTIDEVHRAGGKLKSFLSYCGGLPAPEDSDNPLGYKFSWSSRGVLLALRNSAKYWKDGKIETVSSEDLMATAKPYFIYPGYAFVCYPNRDSTLFKDLYHIPEAETVIRGTLRYQGFPEFVKALVDMGMLKDDANEIFSKPIAWNEALKQYLGAKSTSKEDLIASIDSKATWKDDEDRERILSGFAWLGLFSDAKITPRGNALDTLCARLEELMQYEDNERDMVVLQHKFGIEWADGTTETRTSTLVDYGKVGGYSSMAATVGYPVAIATKFVLDGTIKGPGLLAPYSPEINDPIMKELKDKYGIYLKEKTVA"},{"created_at":"2011-05-26T19:17:15.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"L-aminoadipate-semialdehyde dehydrogenase","uniprot_id":"P07702","uniprot_name":"LYS2_YEAST","enzyme":true,"transporter":false,"gene_name":"LYS2","num_residues":1392,"molecular_weight":"155344.0","theoretical_pi":"5.75","general_function":"Involved in ligase activity","specific_function":"Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha- aminoadipate by NADPH","reactions":[{"id":2563,"direction":"\u003e","locations":null,"altext":"L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":4176,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006475","source":"Smpdb"},{"id":4177,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006476","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M36287","genbank_protein_id":"171867","gene_card_id":"LYS2","chromosome_location":"chromosome 2","locus":"YBR115C","synonyms":["Alpha-aminoadipate reductase","Alpha-AR"],"enzyme_classes":["1.2.1.31"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" phosphopantetheine binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" substrate-specific transporter activity"},{"category":"Function","description":" acyl carrier activity"},{"category":"Function","description":" L-aminoadipate-semialdehyde dehydrogenase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" carboxylic acid binding"},{"category":"Function","description":" amino acid binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" lysine metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" lysine biosynthetic process"}],"pfams":[{"name":"AMP-binding","identifier":"PF00501"},{"name":"PP-binding","identifier":"PF00550"},{"name":"NAD_binding_4","identifier":"PF07993"}],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Lysine degradation","kegg_map_id":"00310"},{"name":"lysine metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTAACGAAAAGGTCTGGATAGAGAAGTTGGATAATCCAACTCTTTCAGTGTTACCACATGACTTTTTACGCCCACAACAAGAACCTTATACGAAACAAGCTACATATTCGTTACAGCTACCTCAGCTCGATGTGCCTCATGATAGTTTTTCTAACAAATACGCTGTCGCTTTGAGTGTATGGGCTGCATTGATATATAGAGTAACCGGTGACGATGATATTGTTCTTTATATTGCGAATAACAAAATCTTAAGATTCAATATTCAACCAACGTGGTCATTTAATGAGCTGTATTCTACAATTAACAATGAGTTGAACAAGCTCAATTCTATTGAGGCCAATTTTTCCTTTGACGAGCTAGCTGAAAAAATTCAAAGTTGCCAAGATCTGGAAAGGACCCCTCAGTTGTTCCGTTTGGCCTTTTTGGAAAACCAAGATTTCAAATTAGACGAGTTCAAGCATCATTTAGTGGACTTTGCTTTGAATTTGGATACCAGTAATAATGCGCATGTTTTGAACTTAATTTATAACAGCTTACTGTATTCGAATGAAAGAGTAACCATTGTTGCGGACCAATTTACTCAATATTTGACTGCTGCGCTAAGCGATCCATCCAATTGCATAACTAAAATCTCTCTGATCACCGCATCATCCAAGGATAGTTTACCTGATCCAACTAAGAACTTGGGCTGGTGCGATTTCGTGGGGTGTATTCACGACATTTTCCAGGACAATGCTGAAGCCTTCCCAGAGAGAACCTGTGTTGTGGAGACTCCAACACTAAATTCCGACAAGTCCCGTTCTTTCACTTATCGCGACATCAACCGCACTTCTAACATAGTTGCCCATTATTTGATTAAAACAGGTATCAAAAGAGGTGATGTAGTGATGATCTATTCTTCTAGGGGTGTGGATTTGATGGTATGTGTGATGGGTGTCTTGAAAGCCGGCGCAACCTTTTCAGTTATCGACCCTGCATATCCCCCAGCCAGACAAACCATTTACTTAGGTGTTGCTAAACCACGTGGGTTGATTGTTATTAGAGCTGCTGGACAATTGGATCAACTAGTAGAAGATTACATCAATGATGAATTGGAGATTGTTTCAAGAATCAATTCCATCGCTATTCAAGAAAATGGTACCATTGAAGGTGGCAAATTGGACAATGGCGAGGATGTTTTGGCTCCATATGATCACTACAAAGACACCAGAACAGGTGTTGTAGTTGGACCAGATTCCAACCCAACCCTATCTTTCACATCTGGTTCCGAAGGTATTCCTAAGGGTGTTCTTGGTAGACATTTTTCCTTGGCTTATTATTTCAATTGGATGTCCAAAAGGTTCAACTTAACAGAAAATGATAAATTCACAATGCTGAGCGGTATTGCACATGATCCAATTCAAAGAGATATGTTTACACCATTATTTTTAGGTGCCCAATTGTATGTCCCTACTCAAGATGATATTGGTACACCGGGCCGTTTAGCGGAATGGATGAGTAAGTATGGTTGCACAGTTACCCATTTAACACCTGCCATGGGTCAATTACTTACTGCCCAAGCTACTACACCATTCCCTAAGTTACATCATGCGTTCTTTGTGGGTGACATTTTAACAAAACGTGATTGTCTGAGGTTACAAACCTTGGCAGAAAATTGCCGTATTGTTAATATGTACGGTACCACTGAAACACAGCGTGCAGTTTCTTATTTCGAAGTTAAATCAAAAAATGACGATCCAAACTTTTTGAAAAAATTGAAAGATGTCATGCCTGCTGGTAAAGGTATGTTGAACGTTCAGCTACTAGTTGTTAACAGGAACGATCGTACTCAAATATGTGGTATTGGCGAAATAGGTGAGATTTATGTTCGTGCAGGTGGTTTGGCCGAAGGTTATAGAGGATTACCAGAATTGAATAAAGAAAAATTTGTGAACAACTGGTTTGTTGAAAAAGATCACTGGAATTATTTGGATAAGGATAATGGTGAACCTTGGAGACAATTCTGGTTAGGTCCAAGAGATAGATTGTACAGAACGGGTGATTTAGGTCGTTATCTACCAAACGGTGACTGTGAATGTTGCGGTAGGGCTGATGATCAAGTTAAAATTCGTGGGTTCAGAATCGAATTAGGAGAAATAGATACGCACATTTCCCAACATCCATTGGTAAGAGAAAACATTACTTTAGTTCGCAAAAATGCCGACAATGAGCCAACATTGATCACATTTATGGTCCCAAGATTTGACAAGCCAGATGACTTGTCTAAGTTCCAAAGTGATGTTCCAAAGGAGGTTGAAACTGACCCTATAGTTAAGGGCTTAATCGGTTACCATCTTTTATCCAAGGACATCAGGACTTTCTTAAAGAAAAGATTGGCTAGCTATGCTATGCCTTCCTTGATTGTGGTTATGGATAAACTACCATTGAATCCAAATGGTAAAGTTGATAAGCCTAAACTTCAATTCCCAACTCCCAAGCAATTAAATTTGGTAGCTGAAAATACAGTTTCTGAAACTGACGACTCTCAGTTTACCAATGTTGAGCGCGAGGTTAGAGACTTATGGTTAAGTATATTACCTACCAAGCCAGCATCTGTATCACCAGATGATTCGTTTTTCGATTTAGGTGGTCATTCTATCTTGGCTACCAAAATGATTTTTACCTTAAAGAAAAAGCTGCAAGTTGATTTACCATTGGGCACAATTTTCAAGTATCCAACGATAAAGGCCTTTGCCGCGGAAATTGACAGAATTAAATCATCGGGTGGATCATCTCAAGGTGAGGTCGTCGAAAATGTCACTGCAAATTATGCGGAAGACGCCAAGAAATTGGTTGAGACGCTACCAAGTTCGTACCCCTCTCGAGAATATTTTGTTGAACCTAATAGTGCCGAAGGAAAAACAACAATTAATGTGTTTGTTACCGGTGTCACAGGATTTCTGGGCTCCTACATCCTTGCAGATTTGTTAGGACGTTCTCCAAAGAACTACAGTTTCAAAGTGTTTGCCCACGTCAGGGCCAAGGATGAAGAAGCTGCATTTGCAAGATTACAAAAGGCAGGTATCACCTATGGTACTTGGAACGAAAAATTTGCCTCAAATATTAAAGTTGTATTAGGCGATTTATCTAAAAGCCAATTTGGTCTTTCAGATGAGAAGTGGATGGATTTGGCAAACACAGTTGATATAATTATCCATAATGGTGCGTTAGTTCACTGGGTTTATCCATATGCCAAATTGAGGGATCCAAATGTTATTTCAACTATCAATGTTATGAGCTTAGCCGCCGTCGGCAAGCCAAAGTTCTTTGACTTTGTTTCCTCCACTTCTACTCTTGACACTGAATACTACTTTAATTTGTCAGATAAACTTGTTAGCGAAGGGAAGCCAGGCATTTTAGAATCAGACGATTTAATGAACTCTGCAAGCGGGCTCACTGGTGGATATGGTCAGTCCAAATGGGCTGCTGAGTACATCATTAGACGTGCAGGTGAAAGGGGCCTACGTGGGTGTATTGTCAGACCAGGTTACGTAACAGGTGCCTCTGCCAATGGTTCTTCAAACACAGATGATTTCTTATTGAGATTTTTGAAAGGTTCAGTCCAATTAGGTAAGATTCCAGATATCGAAAATTCCGTGAATATGGTTCCAGTAGATCATGTTGCTCGTGTTGTTGTTGCTACGTCTTTGAATCCTCCCAAAGAAAATGAATTGGCCGTTGCTCAAGTAACGGGTCACCCAAGAATATTATTCAAAGACTACTTGTATACTTTACACGATTATGGTTACGATGTCGAAATCGAAAGCTATTCTAAATGGAAGAAATCATTGGAGGCGTCTGTTATTGACAGGAATGAAGAAAATGCGTTGTATCCTTTGCTACACATGGTCTTAGACAACTTACCTGAAAGTACCAAAGCTCCGGAACTAGACGATAGGAACGCCGTGGCATCTTTAAAGAAAGACACCGCATGGACAGGTGTTGATTGGTCTAATGGAATAGGTGTTACTCCAGAAGAGGTTGGTATATATATTGCATTTTTAAACAAGGTTGGATTTTTACCTCCACCAACTCATAATGACAAACTTCCACTGCCAAGTATAGAACTAACTCAAGCGCAAATAAGTCTAGTTGCTTCAGGTGCTGGTGCTCGTGGAAGCTCCGCAGCAGCTTAA","protein_sequence":"MTNEKVWIEKLDNPTLSVLPHDFLRPQQEPYTKQATYSLQLPQLDVPHDSFSNKYAVALSVWAALIYRVTGDDDIVLYIANNKILRFNIQPTWSFNELYSTINNELNKLNSIEANFSFDELAEKIQSCQDLERTPQLFRLAFLENQDFKLDEFKHHLVDFALNLDTSNNAHVLNLIYNSLLYSNERVTIVADQFTQYLTAALSDPSNCITKISLITASSKDSLPDPTKNLGWCDFVGCIHDIFQDNAEAFPERTCVVETPTLNSDKSRSFTYRDINRTSNIVAHYLIKTGIKRGDVVMIYSSRGVDLMVCVMGVLKAGATFSVIDPAYPPARQTIYLGVAKPRGLIVIRAAGQLDQLVEDYINDELEIVSRINSIAIQENGTIEGGKLDNGEDVLAPYDHYKDTRTGVVVGPDSNPTLSFTSGSEGIPKGVLGRHFSLAYYFNWMSKRFNLTENDKFTMLSGIAHDPIQRDMFTPLFLGAQLYVPTQDDIGTPGRLAEWMSKYGCTVTHLTPAMGQLLTAQATTPFPKLHHAFFVGDILTKRDCLRLQTLAENCRIVNMYGTTETQRAVSYFEVKSKNDDPNFLKKLKDVMPAGKGMLNVQLLVVNRNDRTQICGIGEIGEIYVRAGGLAEGYRGLPELNKEKFVNNWFVEKDHWNYLDKDNGEPWRQFWLGPRDRLYRTGDLGRYLPNGDCECCGRADDQVKIRGFRIELGEIDTHISQHPLVRENITLVRKNADNEPTLITFMVPRFDKPDDLSKFQSDVPKEVETDPIVKGLIGYHLLSKDIRTFLKKRLASYAMPSLIVVMDKLPLNPNGKVDKPKLQFPTPKQLNLVAENTVSETDDSQFTNVEREVRDLWLSILPTKPASVSPDDSFFDLGGHSILATKMIFTLKKKLQVDLPLGTIFKYPTIKAFAAEIDRIKSSGGSSQGEVVENVTANYAEDAKKLVETLPSSYPSREYFVEPNSAEGKTTINVFVTGVTGFLGSYILADLLGRSPKNYSFKVFAHVRAKDEEAAFARLQKAGITYGTWNEKFASNIKVVLGDLSKSQFGLSDEKWMDLANTVDIIIHNGALVHWVYPYAKLRDPNVISTINVMSLAAVGKPKFFDFVSSTSTLDTEYYFNLSDKLVSEGKPGILESDDLMNSASGLTGGYGQSKWAAEYIIRRAGERGLRGCIVRPGYVTGASANGSSNTDDFLLRFLKGSVQLGKIPDIENSVNMVPVDHVARVVVATSLNPPKENELAVAQVTGHPRILFKDYLYTLHDYGYDVEIESYSKWKKSLEASVIDRNEENALYPLLHMVLDNLPESTKAPELDDRNAVASLKKDTAWTGVDWSNGIGVTPEEVGIYIAFLNKVGFLPPPTHNDKLPLPSIELTQAQISLVASGAGARGSSAAA"}]}