{"ymdb_id":"YMDB00712","created_at":"2011-05-29T18:45:44.000Z","updated_at":"2016-09-08T18:35:48.000Z","name":"inositol-P-ceramide C (C26)","cas":null,"state":null,"melting_point":null,"description":"Inositol-P-ceramide (IPC) is an intermediate in the sphingolipid metabolism pathway. Sphingolipids are essential components of the plasma membrane in all eukaryotic cells. S. cerevisiae cells make three complex sphingolipids: inositol-phosphoceramide (IPC), mannose-inositol-phosphoceramide (MIPC), and mannosyl-diinositol-phosphorylceramide (M(IP)2C). [Biocyc SPHINGOLIPID-SYN-PWY]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Golgi","synthesis_reference":null,"chebi_id":"53004","hmdb_id":null,"kegg_id":null,"pubchem_id":"44224058","cs_id":"24765754","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"{[(2S,3S,4R)-3,4-dihydroxy-2-(2-hydroxyhexacosanamido)octadecyl]oxy}({[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy})phosphinic acid","traditional_iupac":"[(2S,3S,4R)-3,4-dihydroxy-2-(2-hydroxyhexacosanamido)octadecyl]oxy[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphinic acid","logp":"10.562048570666668","pka":"12.14686002089742","alogps_solubility":"8.61e-04 g/l","alogps_logp":"7.12","alogps_logs":"-6.05","acceptor_count":"11","donor_count":"10","rotatable_bond_count":"45","polar_surface_area":"246.69999999999996","refractivity":"256.5457","polarizability":"116.87541872919351","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-3.595121438454849","pka_strongest_acidic":"1.8429067276140794","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["inositol-P-ceramide","inositol-P-ceramide C (C26)","InsPCer","InsPCer-3 (C26)","InsPCer-C (C26)","IPC","IPC-3 (C26)","IPC-C (C26)"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":9368028,"citation":"Dickson, R. C., Nagiec, E. E., Wells, G. B., Nagiec, M. M., Lester, R. L. (1997). \"Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene.\" J Biol Chem 272:29620-29625."},{"pubmed_id":9092515,"citation":"Nagiec, M. M., Nagiec, E. E., Baltisberger, J. A., Wells, G. B., Lester, R. L., Dickson, R. C. (1997). \"Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.\" J Biol Chem 272:9809-9817."},{"pubmed_id":16730802,"citation":"Dickson, R. C., Sumanasekera, C., Lester, R. L. (2006). \"Functions and metabolism of sphingolipids in Saccharomyces cerevisiae.\" Prog Lipid Res 45:447-465."},{"pubmed_id":12484746,"citation":"Funato, K., Vallee, B., Riezman, H. (2002). \"Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae.\" Biochemistry 41:15105-15114."},{"pubmed_id":9804825,"citation":"Reggiori, F., Conzelmann, A. (1998). \"Biosynthesis of inositol phosphoceramides and remodeling of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae are mediated by different enzymes.\" J Biol Chem 273:30550-30559."}],"proteins":[{"created_at":"2011-05-27T02:08:31.000Z","updated_at":"2011-07-22T17:54:08.000Z","name":"Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2","uniprot_id":"P35206","uniprot_name":"CSG2_YEAST","enzyme":true,"transporter":false,"gene_name":"CSG2","num_residues":410,"molecular_weight":"45441.60156","theoretical_pi":"7.33","general_function":"Involved in enzyme regulator activity","specific_function":"Required for calcium regulation. May regulate calcium accumulation by a non-vacuole organelle. Also regulates the activity of CSH1 and SUR1 during mannosyl phosphorylinositol ceramide synthesis","reactions":[{"id":1295,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1297,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1304,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1306,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"1-17","transmembrane_regions":"51-71;142-161;168-187;198-217;246-265;286-305;325-344;356-374;386-404","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"D28120","genbank_protein_id":"976270","gene_card_id":"CSG2","chromosome_location":"chromosome 2","locus":"YBR036C","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[],"pathways":[],"gene_sequence":"ATGTCTACCACACTACTTTGGTTTTCAAGTGTAATAGGCTACGTGATTCAAACAAAATGTTTGTCTAACATACAATCTAAAAAGGAAATCTCCGTGGGGCCCAATGGTACAATTGCAACGCCTGAAACTAACGGCGACAACGGAAACTCAAGTTCATTAACCTTCTATCTGACCTTTATGTATTTTGCTTCGTGGCTGCTCTTGGTGCCTGCATCTCGACTTTGGGAGAAGATGAGACCGATGTTTGTCTCTGACTCAGACTCGAACAGGAATTCTCAGTTTGACAACAACAACAGCGGGTCTGTGACAAACGAAGATGTCGATACGTTCTCGCACGTGTTGGATGATCCTCAACCACGGATTCCAGCCCAACAGCAGAAGCAAAAAATCATATCCGTGGCTACCTTCAAATATGTGGCTAAGCTAACAGTGCTGGCTCTCATAATGATTGTCGCTGATTTGACTTATAACATGGCTTTGTCATTGTCACCGGCATTTGATGTTGCTTTGATGCAAAATACTGCCATTTTCGAAATTGTCACTTTACTATATGGTGTTTGTGGAATCTCCAGGAAGAACTACGTTTTCCGTAATTTCCTCATCATGATGAACGCGGTCATTGGAATTTTGATCATCTCATACACGAAGGCTACCTGTGACATGCTTGCCGGAAAGCTGTCCGTCAACCCTAACACGGGTGAACTTTCTGACCCATTCTTGTTTGATAGGTTGAAAGGTGCTCTGATTTGCGGCCTTGGTGCTTTGATTATGGGTCCTTTTGCCGTGTTATGGAACCGTTGGTTTTGCAGTAACATTTCCAAGAACGAAAATTCTGCTGTAGTCTTGGTTAAGCAGAGCACCCACATGGCCCTAATCGGTATTATTGGCATGGTAATACTTTTGCCATTTATTCCTAAATTTCCCTCCCGTGAGTCTGTGGAATCCATTTCGTTGTTCTATAATGACAAGAGCTTTTGGTTCTCTCTACTAGGCTCGATTATCTTTGGTTCCTTGCCGAGCTTGATTTCGATATTAGAGTTGAATCGCAAGGCCCCTGCTGAGTATTTGACGACGTGCAACCTGGGAGCTATTATCTTTATGGGGTTAGCTGAGTGGGTTTGCGAACCTACGCAAACCACAATTGTGAGATGGGAAGTCATAGGATACATAATGCTAACGGTAAGTTTGTTGGTCCTATCAGTAACACTCGGGGAAGGTAAATACCACCATTAG","protein_sequence":"MSTTLLWFSSVIGYVIQTKCLSNIQSKKEISVGPNGTIATPETNGDNGNSSSLTFYLTFMYFASWLLLVPASRLWEKMRPMFVSDSDSNRNSQFDNNNSGSVTNEDVDTFSHVLDDPQPRIPAQQQKQKIISVATFKYVAKLTVLALIMIVADLTYNMALSLSPAFDVALMQNTAIFEIVTLLYGVCGISRKNYVFRNFLIMMNAVIGILIISYTKATCDMLAGKLSVNPNTGELSDPFLFDRLKGALICGLGALIMGPFAVLWNRWFCSNISKNENSAVVLVKQSTHMALIGIIGMVILLPFIPKFPSRESVESISLFYNDKSFWFSLLGSIIFGSLPSLISILELNRKAPAEYLTTCNLGAIIFMGLAEWVCEPTQTTIVRWEVIGYIMLTVSLLVLSVTLGEGKYHH"},{"created_at":"2011-05-27T09:13:37.000Z","updated_at":"2011-05-27T15:01:30.000Z","name":"Inositol phosphorylceramide synthase","uniprot_id":"P36107","uniprot_name":"AUR1_YEAST","enzyme":true,"transporter":false,"gene_name":"AUR1","num_residues":401,"molecular_weight":"45192.80078","theoretical_pi":"6.02","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis","reactions":[{"id":1668,"direction":"\u003c\u003e","locations":"Golgi","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1669,"direction":"\u003c\u003e","locations":"Golgi","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1670,"direction":"\u003c\u003e","locations":"Golgi","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1671,"direction":"\u003c\u003e","locations":"Golgi","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"42-62;65-85;88-108;156-176;179-199;246-266;269-289;292-312","pdb_id":null,"cellular_location":"Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein","genbank_gene_id":"U49090","genbank_protein_id":"1515352","gene_card_id":"AUR1","chromosome_location":"chromosome 11","locus":"YKL004W","synonyms":["IPC synthase","Aureobasidin A resistance protein","Phosphatidylinositol:ceramide phosphoinositol transferase"],"enzyme_classes":["2.-.-.-"],"go_classes":[{"category":"Component","description":" membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PAP2","identifier":"PF01569"}],"pathways":[],"gene_sequence":"ATGGCAAACCCTTTTTCGAGATGGTTTCTATCAGAGAGACCTCCAAACTGCCATGTAGCCGATTTAGAAACAAGTTTAGATCCCCATCAAACGTTGTTGAAGGTGCAAAAATACAAACCCGCTTTAAGCGACTGGGTGCATTACATCTTCTTGGGATCCATCATGCTGTTTGTGTTCATTACTAATCCCGCACCTTGGATCTTCAAGATCCTTTTTTATTGTTTCTTGGGCACTTTATTCATCATTCCAGCTACGTCACAGTTTTTCTTCAATGCCTTGCCCATCCTAACATGGGTGGCGCTGTATTTCACTTCATCGTACTTTCCAGATGACCGCAGGCCTCCTATTACTGTCAAAGTGTTACCAGCGGTGGAAACAATTTTATACGGCGACAATTTAAGTGATATTCTTGCAACATCGACGAATTCCTTTTTGGACATTTTAGCATGGTTACCGTACGGACTATTTCATTATGGGGCCCCATTTGTCGTTGCTGCCATCTTATTCGTATTTGGTCCACCAACTGTTTTGCAAGGTTATGCTTTTGCATTTGGTTATATGAACCTGTTTGGTGTTATCATGCAAAATGTCTTTCCAGCCGCTCCCCCATGGTATAAAATTCTCTATGGATTGCAATCAGCCAACTATGATATGCATGGCTCGCCTGGTGGATTAGCTAGAATTGATAAGCTACTCGGTATTAATATGTATACTACAGCTTTTTCAAATTCCTCCGTCATTTTCGGTGCTTTTCCTTCACTGCATTCCGGGTGTGCTACTATGGAAGCCCTGTTTTTCTGTTATTGTTTTCCAAAATTGAAGCCCTTGTTTATTGCTTATGTTTGCTGGTTATGGTGGTCAACTATGTATCTGACACACCATTATTTTGTAGACCTTATGGCAGGTTCTGTGCTGTCATACGTTATTTTCCAGTACACAAAGTACACACATTTACCAATTGTAGATACATCTCTTTTTTGCAGATGGTCATACACTTCAATTGAGAAATACGATATATCAAAGAGTGATCCATTGGCTGCAGATTCAAACGATATCGAAAGTGTCCCTTTGTCCAACTTGGAACTTGACTTTGATCTTAATATGACTGATGAACCCAGTGTAAGCCCTTCGTTATTTGATGGATCTACTTCTGTTTCTCGTTCGTCCGCCACGTCTATAACGTCACTAGGTGTAAAGAGGGCTTAA","protein_sequence":"MANPFSRWFLSERPPNCHVADLETSLDPHQTLLKVQKYKPALSDWVHYIFLGSIMLFVFITNPAPWIFKILFYCFLGTLFIIPATSQFFFNALPILTWVALYFTSSYFPDDRRPPITVKVLPAVETILYGDNLSDILATSTNSFLDILAWLPYGLFHFGAPFVVAAILFVFGPPTVLQGYAFAFGYMNLFGVIMQNVFPAAPPWYKILYGLQSANYDMHGSPGGLARIDKLLGINMYTTAFSNSSVIFGAFPSLHSGCATMEALFFCYCFPKLKPLFIAYVCWLWWSTMYLTHHYFVDLMAGSVLSYVIFQYTKYTHLPIVDTSLFCRWSYTSIEKYDISKSDPLAADSNDIESVPLSNLELDFDLNMTDEPSVSPSLFDGSTSVSRSSATSITSLGVKRA"}]}