{"ymdb_id":"YMDB00701","created_at":"2011-05-29T18:44:42.000Z","updated_at":"2016-09-08T18:35:48.000Z","name":"2-hexaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone","cas":null,"state":null,"melting_point":null,"description":"2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone is involved in the ubiquinone biosynthesis pathway. 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone is created from 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone by ubiquinone biosynthesis monooxygenase Coq7 [EC:1.14.13.-]. 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone is then converted to ubiquinone by hexaprenyldihydroxybenzoate methyltransferase [EC:2.1.1.114].","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion","synthesis_reference":null,"chebi_id":"28753","hmdb_id":null,"kegg_id":"C05805","pubchem_id":"351185","cs_id":"21864920","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"2-[(2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-5-hydroxy-6-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione","traditional_iupac":"2-[(2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-5-hydroxy-6-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione","logp":"10.404443801666666","pka":null,"alogps_solubility":"3.46e-04 g/l","alogps_logp":"8.37","alogps_logs":"-6.22","acceptor_count":"4","donor_count":"1","rotatable_bond_count":"18","polar_surface_area":"63.6","refractivity":"186.64360000000002","polarizability":"72.21519310975569","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-4.092751037914863","pka_strongest_acidic":"8.311634572670004","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone"],"pathways":[{"name":"Ubiquinone and other terpenoid-quinone biosynthesis","kegg_map_id":"00130"},{"name":"Ubiquinone Biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-27T02:37:10.000Z","updated_at":"2011-05-29T05:06:36.000Z","name":"Ubiquinone biosynthesis protein COQ4, mitochondrial","uniprot_id":"O13525","uniprot_name":"COQ4_YEAST","enzyme":true,"transporter":false,"gene_name":"COQ4","num_residues":335,"molecular_weight":"38626.80078","theoretical_pi":"10.13","general_function":"Involved in ubiquinone biosynthetic process","specific_function":"Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides","reactions":[],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"Z68194","genbank_protein_id":"1204149","gene_card_id":"COQ4","chromosome_location":"chromosome 4","locus":"YDR204W","synonyms":["Coenzyme Q biosynthesis protein 4"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" oxidoreduction coenzyme metabolic process"},{"category":"Process","description":" ubiquinone metabolic process"},{"category":"Process","description":" ubiquinone biosynthetic process"}],"pfams":[{"name":"Coq4","identifier":"PF05019"}],"pathways":[],"gene_sequence":"ATGTTGAGGTTATCTTTACTGAGATCAACAGCTACTTTGCCAGTGAAATGCCAACGTCGTGGGCTAATATTACCTGCGGCGGCAATGTACACCTTAGGCTCATTAATATTTGGTAAGGAAGCAAGGTTGGCGGATGCCATGGAACGTGGTGAGTTACATAACAAGAACGTTGATTATGCGAAAGAAGCTGAAGAGCGTACCGAGTTACGTATTAGGGCCCTGGCTAATACTCGGCCAATGGAACCTCGGTACAACGGCCATGTTCCCCTTCATCGGTACGAGAAATTGCTGCTGTTTGCAATTTCCGGTTGGAATTCATTTTTCCATCCTGAAGATGGTTATAATATTGTACAATTGGGTGAGGCAACTGCATTGCCGGTCTTCTTGGAGAATTTGAAGCAAACAATGTTAAGTGATTCCTCTGGGAGGCGCATTTTGAAGGAACAACCCAATATCACAACAGAGATTTTGCATATGGACAAACTAGCTAAATTGCCACATAACACGTTTGGGTATGTATATTACCAATGGTTGAAAAGAGAAAACGTTTCTCCGGACACTAGAGCACCTGTCAAATTTATCGACGATCCTATGCATGCATATATCTTTAAGAGGTATAGACAATGCCACGATTTCTATCACGCTATAACCAACATGCCTATTATCATTGAGGGGGAGATCACCATAAAGGCTCTTGAAGGTGCCAACCTGGGCGTCCCAATGGCCATTCTCGGTGGTATCCTTGCACCTTTACGTTTGAAAAAGGTGCAAAGAAAAAGATTATATAATATATATCTCCCTTGGGCTGTCAGAACAGGTTTAAGCTGCAAGCCATTGATCAACGTGTATTGGGAGGAAATGCTGGAGAAGGATGTTACTGCTTTGAGGAAAGAGCTAAAGATAACACTCCCTCCGGATCTAAGGACAATGAGGAAGGAGCGTGCAGCCCTTAGGAAGGAGATTGACGCAAAATACAACTCACAGAAACGAGCCACGACTCCAGCATGA","protein_sequence":"MLRLSLLRSTATLPVKCQRRGLILPAAAMYTLGSLIFGKEARLADAMERGELHNKNVDYAKEAEERTELRIRALANTRPMEPRYNGHVPLHRYEKLLLFAISGWNSFFHPEDGYNIVQLGEATALPVFLENLKQTMLSDSSGRRILKEQPNITTEILHMDKLAKLPHNTFGYVYYQWLKRENVSPDTRAPVKFIDDPMHAYIFKRYRQCHDFYHAITNMPIIIEGEITIKALEGANLGVPMAILGGILAPLRLKKVQRKRLYNIYLPWAVRTGLSCKPLINVYWEEMLEKDVTALRKELKITLPPDLRTMRKERAALRKEIDAKYNSQKRATTPA"}]}