{"ymdb_id":"YMDB00660","created_at":"2011-05-29T18:41:16.000Z","updated_at":"2016-09-12T20:54:11.000Z","name":"Ubiquinone-6","cas":"1065-31-2","state":"Liquid","melting_point":null,"description":"Ubiquinone-6 is involved in cellular respiration.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion","synthesis_reference":null,"chebi_id":"52971","hmdb_id":null,"kegg_id":"C17568","pubchem_id":"5283544","cs_id":"23354078","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"2-(3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione","traditional_iupac":"2-(3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione","logp":"10.517271190999999","pka":null,"alogps_solubility":"3.25e-04 g/l","alogps_logp":"8.41","alogps_logs":"-6.26","acceptor_count":"4","donor_count":"0","rotatable_bond_count":"19","polar_surface_area":"52.60000000000001","refractivity":"191.3948","polarizability":"73.45267887010665","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-4.718903581971888","pka_strongest_acidic":null,"bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(all-E)-2-(3,7,11,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaenyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione","2,3-dimethoxy-5-methyl-6-hexaprenyl-1,4-benzoquinone","Coenzyme Q6","Coenzyme Qq6","CoQ6","Ubiquinone 30","Ubiquinone 6","Ubiquinone Q6"],"pathways":[{"name":"Ubiquinone and other terpenoid-quinone biosynthesis","kegg_map_id":"00130"},{"name":"Ubiquinone Biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":6296069,"citation":"Sippel, C. J., Goewert, R. R., Slachman, F. N., Olson, R. E. (1983). \"The regulation of ubiquinone-6 biosynthesis by Saccharomyces cerevisiae.\" J Biol Chem 258:1057-1061."}],"proteins":[{"created_at":"2011-05-24T21:12:04.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Deoxyhypusine synthase","uniprot_id":"P38791","uniprot_name":"DHYS_YEAST","enzyme":true,"transporter":false,"gene_name":"DYS1","num_residues":387,"molecular_weight":"42891.80078","theoretical_pi":"5.49","general_function":"Involved in peptidyl-lysine modification to hypusine","specific_function":"Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue","reactions":[{"id":1444,"direction":"\u003e","locations":"mitochondrion;mitochondrial membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2367,"direction":"\u003e","locations":null,"altext":"[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558282","genbank_protein_id":"45270454","gene_card_id":"DYS1","chromosome_location":"chromosome 8","locus":"YHR068W","synonyms":["DHS"],"enzyme_classes":["2.5.1.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" peptidyl-amino acid modification"},{"category":"Process","description":" peptidyl-lysine modification"},{"category":"Process","description":" peptidyl-lysine modification to hypusine"}],"pfams":[{"name":"DS","identifier":"PF01916"}],"pathways":[],"gene_sequence":"ATGTCCGATATCAACGAAAAACTCCCAGAGTTACTACAAGACGCTGTCTTGAAAGCATCTGTTCCTATTCCAGATGACTTCGTTAAGGTTCAAGGTATTGATTACTCAAAGCCTGAAGCCACTAATATGAGAGCAACTGATTTAATTGAAGCTATGAAGACCATGGGTTTCCAAGCTAGTTCTGTTGGTACTGCCTGTGAGATTATTGATAGTATGAGATCATGGAGAGGTAAGCATATTGACGAATTGGATGACCATGAAAAGAAAGGTTGCTTCGATGAGGAAGGGTACCAAAAGACTACTATCTTCATGGGTTATACTTCTAACTTGATCAGTTCCGGTGTACGTGAAACTTTACGTTATTTGGTGCAACACAAAATGGTTGATGCTGTCGTTACTTCTGCTGGTGGTGTGGAAGAAGATTTGATCAAATGTCTTGCTCCAACTTACTTGGGTGAATTTGCTTTGAAAGGTAAATCTTTGCGTGACCAAGGTATGAATCGTATTGGTAACTTGCTTGTTCCAAATGATAACTACTGTAAGTTTGAAGAATGGATTGTCCCAATTTTGGATAAGATGTTGGAAGAACAAGATGAATACGTAAAGAAACATGGCGCTGACTGTTTAGAGGCTAACCAAGACGTGGATTCACCAATCTGGACCCCATCTAAGATGATAGACCGTTTTGGTAAGGAAATCAACGACGAATCCTCCGTATTGTACTGGGCCCACAAGAATAAAATTCCAATCTTTTGTCCATCTTTGACTGATGGTTCAATCGGTGACATGTTGTTTTTCCATACTTTTAAAGCATCTCCAAAACAACTAAGAGTTGACATTGTAGGAGATATCCGCAAAATCAATTCAATGTCCATGGCCGCTTACAGAGCCGGTATGATCATCTTGGGTGGTGGTTTGATCAAGCACCACATTGCCAATGCTTGTTTGATGAGAAATGGTGCTGATTATGCCGTTTACATTAACACTGGTCAAGAATACGATGGTTCTGATGCAGGTGCAAGACCTGACGAAGCTGTGTCTTGGGGTAAGATCAAGGCTGAAGCCAAATCCGTCAAACTTTTTGCTGATGTCACCACTGTTCTTCCATTGATTGTTGCTGCTACCTTTGCCAGTGGTAAACCAATCAAAAAAGTTAAGAATTGA","protein_sequence":"MSDINEKLPELLQDAVLKASVPIPDDFVKVQGIDYSKPEATNMRATDLIEAMKTMGFQASSVGTACEIIDSMRSWRGKHIDELDDHEKKGCFDEEGYQKTTIFMGYTSNLISSGVRETLRYLVQHKMVDAVVTSAGGVEEDLIKCLAPTYLGEFALKGKSLRDQGMNRIGNLLVPNDNYCKFEEWIVPILDKMLEEQDEYVKKHGADCLEANQDVDSPIWTPSKMIDRFGKEINDESSVLYWAHKNKIPIFCPSLTDGSIGDMLFFHTFKASPKQLRVDIVGDIRKINSMSMAAYRAGMIILGGGLIKHHIANACLMRNGADYAVYINTGQEYDGSDAGARPDEAVSWGKIKAEAKSVKLFADVTTVLPLIVAATFASGKPIKKVKN"},{"created_at":"2011-05-26T18:02:04.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"External NADH-ubiquinone oxidoreductase 2, mitochondrial","uniprot_id":"Q07500","uniprot_name":"NDH2_YEAST","enzyme":true,"transporter":false,"gene_name":"NDE2","num_residues":545,"molecular_weight":"61658.69922","theoretical_pi":"9.07","general_function":"Involved in oxidoreductase activity","specific_function":"External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE1, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxydation","reactions":[{"id":1764,"direction":"\u003e","locations":"mitochondrion;mitochondrial membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2504,"direction":"\u003e","locations":"Mitochondrion intermembrane space; Matrix side.; Peripheral membrane protein;Mitochondrion inner membrane","altext":"NADH + ubiquinone = NAD(+) + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"Z74133","genbank_protein_id":"1431110","gene_card_id":"NDE2","chromosome_location":"chromosome 4","locus":"YDL085W","synonyms":["External NADH dehydrogenase 2"],"enzyme_classes":["1.6.5.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Pyr_redox","identifier":"PF00070"},{"name":"Pyr_redox_2","identifier":"PF07992"}],"pathways":[{"name":"Oxidative phosphorylation","kegg_map_id":"00190"}],"gene_sequence":"ATGCTGCCCAGACTTGGTTTTGCGAGGACTGCTAGGTCCATACACCGTTTCAAGATGACCCAGATCTCTAAACCTTTTTTCCATTCCACTGAAGTTGGTAAGCCCGGACCACAGCAGAAGCTATCGAAATCTTACACTGCGGTATTCAAGAAATGGTTTGTCAGAGGTTTAAAGTTAACCTTTTACACGACGTTGGCCGGCACATTGTATGTGTCATACGAGCTGTACAAAGAATCGAACCCACCCAAACAGGTTCCCCAATCGACCGCTTTTGCTAATGGTTTGAAAAAGAAGGAGCTGGTTATTTTGGGTACAGGCTGGGGCGCCATATCTCTTTTGAAGAAATTAGACACGTCTTTGTATAACGTGACCGTGGTGTCGCCAAGAAGCTTCTTTTTGTTCACACCGTTATTACCCTCAACGCCTGTGGGTACGATAGAGATGAAGTCTATTGTCGAACCGGTTAGATCGATCGCTAGAAGAACGCCTGGAGAAGTTCACTACATTGAGGCGGAAGCGTTGGACGTTGATCCAAAGGCCAAAAAAGTAATGGTGCAATCGGTGTCAGAGGACGAATATTTCGTTTCGAGCTTAAGTTACGATTATCTTGTTGTTAGTGTAGGCGCTAAAACCACTACTTTTAACATTCCCGGGGTCTATGGCAATGCTAACTTCTTGAAAGAGATTGAAGATGCTCAAAATATTCGTATGAAGTTAATGAAAACCATAGAACAGGCAAGTTCATTTCCTGTGAACGATCCGGAAAGGAAGCGATTATTAACGTTCGTGGTTGTTGGAGGGGGCCCTACGGGGGTTGAATTTGCCGCCGAACTGCAAGATTACATCAATCAAGATTTGAGGAAGTGGATGCCCGACTTAAGTAAAGAAATGAAGGTTATCTTAATTGAAGCCCTGCCTAATATCCTAAACATGTTCGATAAGACGTTGATCAAGTATGCCGAGGACCTTTTTGCCAGAGATGAAATTGACTTGCAAGTGAATACTGCCGTGAAAGTCGTAGAGCCAACCTATATACGCACTCTGCAAAACGGCCAAACAAACACGGATATCGAATACGGGATGCTGGTTTGGGCCACGGGAAATGAACCAATCGATTTTTCAAAGACACTGATGAGTAGAATACCGGAGCAAACTAATAGGCGTGGTCTGTTAATTAATGACAAGTTGGAGCTTCTCGGTTCTGAGAATTCGATTTATGCAATTGGTGATTGTACCGCACACACGGGTTTCTTTCCCACGGCACAAGTTGCACATCAGGAAGGCGAATACTTGGCCAAGATCTTGGATAAAAAATTACAGATAGAACAATTGGAATGGGACATGCTCAACAGTACCGATGAAACTGAGGTATCACGTCTACAAAAAGAGGTTAATTTGAGGAAATCTAAGTTGGATAAGTTCAACTACAAGCATATGGGTGCCCTTGCGTACATCGGCTCTGAAACCGCAATTGCAGATTTGCATATGGGCGACTCATCATACCAGTTGAAAGGTATGTTTGCCTTCTTGTTTTGGAAATCCGCTTATTTGGCCATGTGTCTCTCTATCAGGAATAGGATTTTAATTGCCATGGACTGGACCAAAGTTTACTTTCTTGGAAGGGATTCCTCCGTGTAG","protein_sequence":"MLPRLGFARTARSIHRFKMTQISKPFFHSTEVGKPGPQQKLSKSYTAVFKKWFVRGLKLTFYTTLAGTLYVSYELYKESNPPKQVPQSTAFANGLKKKELVILGTGWGAISLLKKLDTSLYNVTVVSPRSFFLFTPLLPSTPVGTIEMKSIVEPVRSIARRTPGEVHYIEAEALDVDPKAKKVMVQSVSEDEYFVSSLSYDYLVVSVGAKTTTFNIPGVYGNANFLKEIEDAQNIRMKLMKTIEQASSFPVNDPERKRLLTFVVVGGGPTGVEFAAELQDYINQDLRKWMPDLSKEMKVILIEALPNILNMFDKTLIKYAEDLFARDEIDLQVNTAVKVVEPTYIRTLQNGQTNTDIEYGMLVWATGNEPIDFSKTLMSRIPEQTNRRGLLINDKLELLGSENSIYAIGDCTAHTGFFPTAQVAHQEGEYLAKILDKKLQIEQLEWDMLNSTDETEVSRLQKEVNLRKSKLDKFNYKHMGALAYIGSETAIADLHMGDSSYQLKGMFAFLFWKSAYLAMCLSIRNRILIAMDWTKVYFLGRDSSV"},{"created_at":"2011-05-26T18:02:56.000Z","updated_at":"2011-05-29T05:06:21.000Z","name":"External NADH-ubiquinone oxidoreductase 1, mitochondrial","uniprot_id":"P40215","uniprot_name":"NDH1_YEAST","enzyme":true,"transporter":false,"gene_name":"NDE1","num_residues":560,"molecular_weight":"62773.60156","theoretical_pi":"9.73","general_function":"Involved in oxidoreductase activity","specific_function":"External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE2, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxydation","reactions":[{"id":1764,"direction":"\u003e","locations":"mitochondrion;mitochondrial membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2504,"direction":"\u003e","locations":"Mitochondrion intermembrane space; Matrix side.; Peripheral membrane protein;Mitochondrion inner membrane","altext":"NADH + ubiquinone = NAD(+) + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"AY692785","genbank_protein_id":"51013021","gene_card_id":"NDE1","chromosome_location":"chromosome 13","locus":"YMR145C","synonyms":["External NADH dehydrogenase 1"],"enzyme_classes":["1.6.5.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Pyr_redox","identifier":"PF00070"},{"name":"Pyr_redox_2","identifier":"PF07992"}],"pathways":[{"name":"Oxidative phosphorylation","kegg_map_id":"00190"}],"gene_sequence":"ATGATTAGACAATCATTAATGAAAACAGTGTGGGCTAACTCCTCCAGGTTTAGCCTACAGAGCAAGTCGGGGCTTGTGAAATATGCCAAAAATAGATCGTTCCATGCAGCAAGAAATTTGCTAGAGGACAAGAAAGTCATTTTGCAAAAAGTGGCGCCCACTACTGGCGTTGTTGCGAAGCAGTCCTTTTTCAAGAGAACTGGGAAATTTACTTTGAAGGCTTTATTGTATTCTGCCCTCGCGGGTACGGCTTACGTTTCATACTCACTTTACCGAGAAGCTAACCCTTCTACCCAAGTTCCTCAATCGGACACTTTTCCAAACGGTTCAAAGAGGAAGACTTTGGTAATTCTGGGCTCCGGTTGGGGTTCTGTGTCGCTTTTGAAAAATTTGGACACCACGTTGTATAATGTTGTTGTTGTTTCTCCAAGAAATTATTTTCTTTTTACTCCGCTATTGCCATCTACCCCAGTTGGTACCATCGAATTGAAATCTATTGTTGAACCTGTCAGGACTATTGCTAGAAGATCGCACGGTGAAGTCCATTACTATGAAGCTGAAGCGTACGACGTTGATCCTGAAAACAAAACAATTAAGGTCAAATCTTCCGCTAAGAATAACGACTACGACTTGGACTTGAAATACGACTATCTGGTTGTCGGTGTGGGTGCTCAACCAAACACTTTTGGTACTCCGGGAGTTTATGAATATTCTTCTTTCTTGAAGGAAATATCCGACGCTCAAGAGATCAGATTAAAAATTATGTCCAGTATTGAGAAAGCTGCCTCCCTATCTCCAAAAGATCCTGAGAGAGCAAGATTGTTGAGCTTTGTTGTCGTTGGTGGTGGTCCCACCGGTGTCGAATTTGCCGCTGAATTGAGAGATTATGTTGACCAGGACTTGAGAAAATGGATGCCCGAATTGAGTAAAGAAATTAAAGTCACTTTGGTGGAGGCTTTGCCAAACATTTTGAACATGTTTGACAAGTATCTCGTTGACTATGCTCAAGATTTATTCAAAGAGGAAAAAATCGATTTAAGATTGAAAACAATGGTTAAGAAAGTTGACGCTACCACTATAACTGCCAAAACTGGCGATGGTGACATTGAAAATATACCGTATGGTGTATTAGTTTGGGCTACAGGTAATGCGCCAAGAGAAGTGTCTAAGAACCTAATGACTAAATTAGAGGAACAGGACTCAAGACGTGGTTTGTTGATAGATAACAAACTTCAACTTTTGGGTGCTAAGGGATCTATTTTTGCTATCGGCGATTGTACCTTCCACCCTGGCTTGTTCCCTACCGCTCAAGTTGCCCACCAAGAAGGTGAATACTTGGCTCAGTATTTCAAGAAAGCTTATAAAATCGATCAATTGAACTGGAAAATGACCCATGCTAAAGACGATTCAGAAGTCGCTAGATTAAAGAACCAAATAGTCAAAACGCAATCGCAAATTGAAGACTTCAAGTACAACCATAAGGGTGCTCTGGCTTATATTGGTTCAGATAAAGCCATTGCTGATCTTGCCGTTGGTGAAGCCAAATATAGGTTAGCCGGCTCATTCACCTTCCTATTCTGGAAATCTGCTTATTTGGCAATGTGTCTATCCTTTAGAAACAGAGTTCTTGTCGCTATGGATTGGGCTAAAGTTTATTTCTTGGGTAGAGATTCATCTATCTAG","protein_sequence":"MIRQSLMKTVWANSSRFSLQSKSGLVKYAKNRSFHAARNLLEDKKVILQKVAPTTGVVAKQSFFKRTGKFTLKALLYSALAGTAYVSYSLYREANPSTQVPQSDTFPNGSKRKTLVILGSGWGSVSLLKNLDTTLYNVVVVSPRNYFLFTPLLPSTPVGTIELKSIVEPVRTIARRSHGEVHYYEAEAYDVDPENKTIKVKSSAKNNDYDLDLKYDYLVVGVGAQPNTFGTPGVYEYSSFLKEISDAQEIRLKIMSSIEKAASLSPKDPERARLLSFVVVGGGPTGVEFAAELRDYVDQDLRKWMPELSKEIKVTLVEALPNILNMFDKYLVDYAQDLFKEEKIDLRLKTMVKKVDATTITAKTGDGDIENIPYGVLVWATGNAPREVSKNLMTKLEEQDSRRGLLIDNKLQLLGAKGSIFAIGDCTFHPGLFPTAQVAHQEGEYLAQYFKKAYKIDQLNWKMTHAKDDSEVARLKNQIVKTQSQIEDFKYNHKGALAYIGSDKAIADLAVGEAKYRLAGSFTFLFWKSAYLAMCLSFRNRVLVAMDWAKVYFLGRDSSI"},{"created_at":"2011-05-26T18:03:39.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial","uniprot_id":"P32340","uniprot_name":"NDI1_YEAST","enzyme":true,"transporter":false,"gene_name":"NDI1","num_residues":513,"molecular_weight":"57249.30078","theoretical_pi":"9.96","general_function":"Involved in oxidoreductase activity","specific_function":"Catalyzes the oxidation of NADH generated inside the Mitochondrion","reactions":[{"id":1766,"direction":"\u003e","locations":"mitochondrion;mitochondrial membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2504,"direction":"\u003e","locations":"Mitochondrion intermembrane space; Matrix side.; Peripheral membrane protein;Mitochondrion inner membrane","altext":"NADH + ubiquinone = NAD(+) + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.","genbank_gene_id":"AY723851","genbank_protein_id":"51830478","gene_card_id":"NDI1","chromosome_location":"chromosome 13","locus":"YML120C","synonyms":["Internal NADH dehydrogenase"],"enzyme_classes":["1.6.5.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Pyr_redox","identifier":"PF00070"},{"name":"Pyr_redox_2","identifier":"PF07992"}],"pathways":[{"name":"Oxidative phosphorylation","kegg_map_id":"00190"}],"gene_sequence":"ATGCTATCGAAGAATTTGTATAGTAACAAGAGGTTGCTCACCTCGACGAATACGCTAGTCAGATTCGCTTCCACCAGATCCACAGGGGTGGAAAACTCCGGAGCAGGTCCTACATCTTTTAAGACCATGAAAGTCATTGACCCTCAGCACAGCGACAAACCAAACGTGCTGATACTGGGTTCGGGGTGGGGAGCTATTTCGTTTTTAAAGCACATTGACACCAAGAAGTACAACGTTTCCATCATCTCTCCTAGAAGCTATTTCTTATTTACGCCTTTGTTACCTTCTGCACCAGTTGGGACAGTAGACGAAAAGTCAATTATTGAGCCCATCGTTAATTTTGCTCTCAAGAAAAAGGGGAACGTTACCTACTATGAGGCAGAAGCCACCTCTATCAATCCCGACAGGAATACCGTTACCATAAAATCATTATCTGCCGTTAGCCAGCTATACCAACCTGAAAACCATCTAGGGCTGCATCAAGCAGAACCTGCTGAAATTAAGTACGATTATTTAATCAGTGCTGTAGGTGCGGAACCTAACACATTTGGTATTCCTGGGGTCACTGATTACGGTCATTTCCTGAAGGAAATTCCCAACTCTTTGGAAATAAGAAGAACTTTTGCCGCCAATCTAGAGAAGGCTAACTTATTGCCAAAGGGTGATCCCGAAAGAAGAAGACTACTGTCCATTGTCGTGGTTGGTGGTGGGCCTACTGGTGTAGAGGCCGCTGGTGAACTACAGGATTATGTTCACCAGGACCTGAGAAAGTTTCTCCCTGCATTGGCCGAAGAAGTCCAAATTCACTTGGTCGAAGCTCTGCCCATCGTTTTGAATATGTTTGAGAAAAAGCTTTCATCATACGCGCAATCACATTTAGAAAACACTTCGATCAAAGTACATCTGAGAACGGCTGTCGCCAAAGTTGAAGAAAAGCAATTGTTGGCAAAGACCAAACACGAAGACGGTAAAATAACCGAAGAAACTATTCCATACGGTACTTTGATTTGGGCCACGGGTAACAAGGCAAGACCGGTAATCACTGACCTTTTCAAGAAAATTCCTGAGCAAAACTCGTCCAAGAGAGGATTGGCAGTGAATGACTTTTTGCAGGTGAAAGGCAGCAACAACATTTTCGCCATTGGTGACAATGCATTTGCTGGGTTGCCACCAACCGCCCAAGTAGCGCACCAAGAGGCCGAATATTTGGCCAAGAATTTTGATAAAATGGCTCAAATACCAAATTTCCAAAAGAATCTATCTTCAAGAAAGGATAAAATTGATCTCTTGTTCGAGGAGAACAACTTTAAACCTTTCAAATACAACGATTTAGGTGCCTTAGCATACCTGGGATCCGAAAGGGCCATTGCAACCATACGTTCCGGTAAGAGAACATTTTACACCGGTGGTGGCTTAATGACCTTCTACTTATGGAGAATTTTGTACTTGTCCATGATTCTATCTGCAAGATCGAGATTAAAGGTCTTTTTCGACTGGATTAAATTAGCATTTTTCAAAAGAGACTTTTTTAAAGGATTATAG","protein_sequence":"MLSKNLYSNKRLLTSTNTLVRFASTRSTGVENSGAGPTSFKTMKVIDPQHSDKPNVLILGSGWGAISFLKHIDTKKYNVSIISPRSYFLFTPLLPSAPVGTVDEKSIIEPIVNFALKKKGNVTYYEAEATSINPDRNTVTIKSLSAVSQLYQPENHLGLHQAEPAEIKYDYLISAVGAEPNTFGIPGVTDYGHFLKEIPNSLEIRRTFAANLEKANLLPKGDPERRRLLSIVVVGGGPTGVEAAGELQDYVHQDLRKFLPALAEEVQIHLVEALPIVLNMFEKKLSSYAQSHLENTSIKVHLRTAVAKVEEKQLLAKTKHEDGKITEETIPYGTLIWATGNKARPVITDLFKKIPEQNSSKRGLAVNDFLQVKGSNNIFAIGDNAFAGLPPTAQVAHQEAEYLAKNFDKMAQIPNFQKNLSSRKDKIDLLFEENNFKPFKYNDLGALAYLGSERAIATIRSGKRTFYTGGGLMTFYLWRILYLSMILSARSRLKVFFDWIKLAFFKRDFFKGL"},{"created_at":"2011-05-26T18:06:41.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial","uniprot_id":"P21801","uniprot_name":"DHSB_YEAST","enzyme":true,"transporter":false,"gene_name":"SDH2","num_residues":266,"molecular_weight":"30230.90039","theoretical_pi":"8.97","general_function":"Involved in 2 iron, 2 sulfur cluster binding","specific_function":"Subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null},{"id":3707,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003287","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"AY558189","genbank_protein_id":"45270268","gene_card_id":"SDH2","chromosome_location":"chromosome 12","locus":"YLL041C","synonyms":["Iron-sulfur subunit of complex II","Ip"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"}],"pfams":[{"name":"Fer2","identifier":"PF00111"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTGAACGTGCTATTGAGAAGGAAGGCCTTTTGTTTGGTGACGAAGAAGGGTATGGCTACTGCCACAACAGCTGCAGCTACGCATACCCCCAGATTGAAAACTTTTAAAGTTTACAGATGGAATCCAGACGAGCCAAGTGCTAAACCTCATTTACAGTCATATCAAGTGGATCTGAATGACTGTGGGCCCATGGTACTTGATGCGCTGTTAAAGATCAAAGACGAACAGGATTCTACCCTAACTTTTAGAAGATCATGTAGAGAAGGTATCTGCGGTTCATGTGCCATGAACATTGGCGGTAGAAACACGCTAGCTTGTATATGTAAGATCGACCAGAACGAATCCAAACAACTCAAGATCTATCCATTACCCCACATGTTTATTGTCAAAGATTTGGTACCTGATTTAACTAACTTCTACCAACAATACAAATCTATCCAACCTTACTTACAGAGATCATCGTTTCCAAAGGATGGAACGGAAGTGCTACAAAGTATTGAAGATCGTAAGAAACTGGATGGTCTTTACGAATGTATTCTGTGTGCATGCTGCTCTACTTCATGTCCATCGTACTGGTGGAACCAAGAACAGTATTTGGGCCCTGCCGTGCTAATGCAAGCCTACCGTTGGCTAATTGACTCTAGAGACCAAGCTACAAAGACAAGAAAGGCCATGCTAAACAACTCCATGTCATTGTACAGATGTCACACCATCATGAACTGTACTAGAACTTGTCCAAAGGGCTTGAATCCTGGTTTGGCTATTGCTGAAATTAAGAAATCTTTGGCATTTGCCTAG","protein_sequence":"MLNVLLRRKAFCLVTKKGMATATTAAATHTPRLKTFKVYRWNPDEPSAKPHLQSYQVDLNDCGPMVLDALLKIKDEQDSTLTFRRSCREGICGSCAMNIGGRNTLACICKIDQNESKQLKIYPLPHMFIVKDLVPDLTNFYQQYKSIQPYLQRSSFPKDGTEVLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQEQYLGPAVLMQAYRWLIDSRDQATKTRKAMLNNSMSLYRCHTIMNCTRTCPKGLNPGLAIAEIKKSLAFA"},{"created_at":"2011-05-27T07:14:15.000Z","updated_at":"2011-07-22T17:54:36.000Z","name":"Dihydroorotate dehydrogenase","uniprot_id":"P28272","uniprot_name":"PYRD_YEAST","enzyme":true,"transporter":false,"gene_name":"URA1","num_residues":314,"molecular_weight":"34800.60156","theoretical_pi":"5.85","general_function":"Involved in catalytic activity","specific_function":"In the de novo pyrimidine biosynthesic pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate and the reduction of fumarate to succinate. Does not use oxaloacetate and NAD or NADP as electron acceptors","reactions":[{"id":1453,"direction":"\u003e","locations":"mitochondrion;mitochondrial membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1454,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1554,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2803,"direction":"\u003e","locations":"Cytoplasm","altext":"(S)-dihydroorotate + O(2) = orotate + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2804,"direction":"\u003e","locations":"Cytoplasm","altext":"(S)-dihydroorotate + a quinone = orotate + a quinol","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AJ585637","genbank_protein_id":"45719878","gene_card_id":"URA1","chromosome_location":"chromosome 11","locus":"YKL216W","synonyms":["DHOD","DHODase","DHOdehase","Dihydroorotate oxidase"],"enzyme_classes":["1.3.3.1","1.3.5.2"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor"},{"category":"Function","description":" dihydroorotate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" dihydroorotate oxidase activity"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" nucleobase metabolic process"},{"category":"Process","description":" pyrimidine base metabolic process"},{"category":"Process","description":" pyrimidine base biosynthetic process"},{"category":"Process","description":" 'de novo' pyrimidine base biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" pyrimidine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" pyrimidine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" UMP biosynthetic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"DHO_dh","identifier":"PF01180"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGACAGCCAGTTTAACTACCAAGTTCTTGAACAATACCTATGAAAACCCATTTATGAATGCATCCGGTGTTCATTGCATGACTACACAAGAATTAGATGAATTAGCAAACTCTAAAGCTGGCGCATTCATTACAAAGAGTGCTACAACCTTAGAAAGAGAAGGTAACCCTGAACCACGTTACATTTCTGTCCCTCTAGGCAGTATCAACTCCATGGGTTTACCAAACGAAGGTATCGACTACTATTTGTCCTATGTATTAAACCGTCAAAAGAATTATCCTGATGCACCTGCTATTTTCTTCTCAGTTGCTGGTATGAGCATTGATGAAAATTTAAATTTGTTGAGGAAAATCCAAGATAGCGAATTCAACGGTATTACCGAGTTAAACTTGTCTTGTCCTAATGTGCCTGGGAAACCACAAGTTGCTTATGACTTTGACTTGACAAAGGAAACCTTGGAAAAGGTTTTTGCCTTTTTCAAAAAACCTCTTGGTGTCAAGTTGCCTCCTTATTTTGATTTTGCCCATTTTGATATCATGGCAAAAATATTGAACGAGTTCCCATTAGCTTATGTCAACTCTATCAATAGTATAGGAAATGGTCTTTTCATTGATGTGGAGAAGGAGAGTGTAGTAGTGAAGCCAAAGAATGGTTTCGGGGGTATTGGAGGTGAATATGTTAAGCCAACCGCGCTCGCCAATGTTCGTGCATTTTACACTCGTTTGAGACCTGAAATCAAAGTTATCGGTACAGGTGGAATTAAGTCCGGTAAGGATGCATTTGAACATCTTCTATGTGGTGCCTCTATGCTACAGATTGGTACAGAATTACAAAAAGAGGGCGTCAAGATTTTTGAACGTATCGAAAAAGAATTAAAAGACATAATGGAAGCTAAGGGTTATACATCCATAGATCAGTTCCGTGGGAAGTTGAACAGCATTTAA","protein_sequence":"MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI"},{"created_at":"2011-05-27T07:28:41.000Z","updated_at":"2011-05-29T05:06:46.000Z","name":"Cytochrome c iso-1","uniprot_id":"P00044","uniprot_name":"CYC1_YEAST","enzyme":true,"transporter":false,"gene_name":"CYC1","num_residues":109,"molecular_weight":"12181.90039","theoretical_pi":"9.96","general_function":"Involved in iron ion binding","specific_function":"Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain","reactions":[{"id":14426,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006939","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"2PCC","cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"L26347","genbank_protein_id":"695795","gene_card_id":"CYC1","chromosome_location":"chromosome 10","locus":"YJR048W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" electron carrier activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Cytochrom_C","identifier":"PF00034"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGACTGAATTCAAGGCCGGTTCTGCTAAGAAAGGTGCTACACTTTTCAAGACTAGATGTCTACAATGCCACACCGTGGAAAAGGGTGGCCCACATAAGGTTGGTCCAAACTTGCATGGTATCTTTGGCAGACACTCTGGTCAAGCTGAAGGGTATTCGTACACAGATGCCAATATCAAGAAAAACGTGTTGTGGGACGAAAATAACATGTCAGAGTACTTGACTAACCCAAAGAAATATATTCCTGGTACCAAGATGGCCTTTGGTGGGTTGAAGAAGGAAAAAGACAGAAACGACTTAATTACCTACTTGAAAAAAGCCTGTGAGTAA","protein_sequence":"MTEFKAGSAKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGIFGRHSGQAEGYSYTDANIKKNVLWDENNMSEYLTNPKKYIPGTKMAFGGLKKEKDRNDLITYLKKACE"},{"created_at":"2011-05-27T07:29:16.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"Cytochrome c iso-2","uniprot_id":"P00045","uniprot_name":"CYC7_YEAST","enzyme":true,"transporter":false,"gene_name":"CYC7","num_residues":113,"molecular_weight":"12532.2998","theoretical_pi":"10.18","general_function":"Involved in iron ion binding","specific_function":"Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain","reactions":[{"id":14426,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006939","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1YEA","cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"AY693032","genbank_protein_id":"51013515","gene_card_id":"CYC7","chromosome_location":"chromosome 5","locus":"YEL039C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" electron carrier activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Cytochrom_C","identifier":"PF00034"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGGCTAAAGAAAGTACGGGATTCAAACCAGGCTCTGCAAAAAAGGGTGCTACATTGTTTAAAACGAGGTGTCAGCAGTGTCATACAATAGAAGAGGGTGGTCCTAACAAAGTTGGACCTAATTTACATGGTATTTTTGGTAGACATTCAGGTCAGGTAAAGGGTTATTCTTACACAGATGCAAACATCAACAAGAACGTCAAATGGGATGAGGATAGTATGTCCGAGTACTTGACGAACCCAAAGAAATATATTCCTGGTACCAAGATGGCGTTTGCCGGGTTGAAGAAGGAAAAGGACAGAAACGATTTAATTACTTATATGACAAAGGCTGCCAAATAG","protein_sequence":"MAKESTGFKPGSAKKGATLFKTRCQQCHTIEEGGPNKVGPNLHGIFGRHSGQVKGYSYTDANINKNVKWDEDSMSEYLTNPKKYIPGTKMAFAGLKKEKDRNDLITYMTKAAK"}]}