{"ymdb_id":"YMDB00651","created_at":"2011-05-29T18:40:28.000Z","updated_at":"2016-09-08T18:35:44.000Z","name":"Cytosine","cas":"71-30-7","state":"Solid","melting_point":"\u003e300 oC","description":"Cytosine is a pyrimidine nucleobase. Cytosine is found in both DNA and RNA where it binds to guanine to assist in stabilizing the nucleic acid structures.","experimental_water_solubility":"8 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-1.73 [HANSCH,C ET AL. (1995)]","location":"extracellular;cytoplasm","synthesis_reference":"Hitchings, George H.; Elion, Gertrude B.; Falco, Elvira A.; Russell, Peter B. New synthesis of cytosine and 5-methylcytosine. Journal of Biological Chemistry (1949), 177 357-60.","chebi_id":"16040","hmdb_id":"HMDB00630","kegg_id":"C00380","pubchem_id":"597","cs_id":"577","foodb_id":null,"wikipedia_link":"Cytosine","biocyc_id":"CYTOSINE","iupac":"6-amino-1,2-dihydropyrimidin-2-one","traditional_iupac":"2(1H)-pyrimidinone, 6-amino-","logp":"-1.1476057916666667","pka":null,"alogps_solubility":"3.09e+01 g/l","alogps_logp":"-0.94","alogps_logs":"-0.56","acceptor_count":"3","donor_count":"2","rotatable_bond_count":"0","polar_surface_area":"67.48","refractivity":"38.0148","polarizability":"9.883975778125984","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-0.05985282344880383","pka_strongest_acidic":"9.82715733969699","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["4-Amino-2-hydroxypyrimidine","4-Amino-2-oxo-1,2-dihydropyrimidine","4-Amino-2(1H)-pyrimidinone","4-Aminouracil","Cytosine","Cytosinimine"],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-24T21:00:19.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Vitamin B6 transporter TPN1","uniprot_id":"P53099","uniprot_name":"TPN1_YEAST","enzyme":true,"transporter":false,"gene_name":"TPN1","num_residues":579,"molecular_weight":"64545.80078","theoretical_pi":"8.83","general_function":"Involved in nucleobase transmembrane transporter activity","specific_function":"Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine","reactions":[],"signal_regions":"None","transmembrane_regions":"99-119;123-143;158-178;199-219;222-242;275-295;303-323;363-383;395-415;422-442;520-540;546-566","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"X91489","genbank_protein_id":"1143561","gene_card_id":"TPN1","chromosome_location":"chromosome 7","locus":"YGL186C","synonyms":["Transport of pyridoxine protein 1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity"},{"category":"Function","description":" nucleobase transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"}],"pfams":[{"name":"Transp_cyt_pur","identifier":"PF02133"}],"pathways":[],"gene_sequence":"ATGAATAGGGACAACATGGACACAACAAAGCGCAAAGAAGATCATACAAAGCATACTACTGATGTAATAGAATTTTACGAAGAAGGAACCGCAGCTTCTTCTTTAAACATAGCCACAGAAAAGGCCAACTCAAGTCCGTCCATTTTGAGAAGAATTATCAACAGGGCGGCATGGCTTTCTAAGAAAGTGGACGCAATGGGAGTAGAGTCTACCGGTATTCAGAGGATATCTCCCTATGAACGAGGAACATCAAAGAAACAATTTTTGCATGTCGCGGGGCTATGGTTGAGTGCCACAGGTGGTTTGTCTTCCATGTCGTCGTTTTTATTAGGCCCTCTGCTTTTCGGTTTAAGCTTTAGAGAATCCGTAGCCTCCAGTTTAATATCGGTAACAATTGGTTGCTTAATTGCTGCCTATTGCTCGATCATGGGACCGCAGTCCGGTTGCAGACAGATGGTAACAGCTAGATACCTGTTCGGATGGTGGTTTGTTAAATTAGTTGCATTAGCTTCCATTATCGGTGTCATGGGTTGGTCTGTGGTTAATTCCGTGGTTGGGGGTGAAATGTTAGCTGCTATTTCTAATGATAAAGTACCCCTATGGGTAGGGATTGTCATAGTGACCGTATGCTCCTTTTTAGTTGCCATTTTCGGTATCAAACAAGTCATTAAAGTGGAAACTTACTTATCCGTACCCGTCCTGACAGCATTTTTACTACTGTACATTTCATCAAGTGATAAATACAGCTTCGTCAATGCATACGTTTCAAAGGGAAATTTGGACTCTTCCACCCGAAAGGGCAACTGGATGAGTTTTTTTTCATTATGCTATAGTATTACGGCTACTTGGGGGTCTATTACAGCAGACTATTATATATTGTTCCCAGAAGATACACCATATATTCAAATTTTTTGCCTAACGTTTTTTGGAACATTTTTGCCTACCTGTTTCGTCGGAATCTTAGGTCTCTTACTAGCTTCTGTTGCCATGTCGTATAAGCCTTGGTCAGTCGAGTACGATTCCCATGGAATGGGTGGTCTACTTTGGGCAGGTTTTCAGCGTTGGAACGGCTTCGGAAAGTTCTGCGTGGTAGTACTGGTATTCAGTTTGGTATCCAACAACATCATCAATACGTATTCGGCAGCATTCTCCATCCAACTTTCTAGTGTGTTTTGTGCAAAAATCCCTCGCTGGTTCTGGTCTATTGTTTGTACTATAATTTGTTTGGTATGCGCATTAATAGGTCGTAATCATTTTAGTACTATTTTGGGAAATTTCCTACCAATGATAGGCTACTGGATTAGCATGTACTTTATCTTATTATTCGAAGAGAATTTAGTATTCAGAAGGTTTTTCTTACATTTGTACACCAAAGAGTTTCCTACAGTTACAGGAGAAATAAATGGACCGGAACTTGTTGGATCTTCAAAAGAAGTGGAGAAAGATGCAGTTACTAATATCCATTTGTTAAAAAGAAAACATAAGGTGACTAAACATCGTTACAATTGGGACAAATGGGAAGATTATGAGGTTTTAACGCACGGTTATGCAGCAACATTTGCGTTTATTGTAGGAGTTGCTGGTGTGGTAGTTGGTATGGCGCAAGCCTATTGGATTGGCCCAATTGCTGCCAAATTTGGTGAATATGGTGGTGATGTCGCAATGTGGTTAAGTATGGCGTTCTCAGGTGTTGTATACCCTCCTTGTAGATACTTAGAGCTACGTAAATTTGGTCGTTAA","protein_sequence":"MNRDNMDTTKRKEDHTKHTTDVIEFYEEGTAASSLNIATEKANSSPSILRRIINRAAWLSKKVDAMGVESTGIQRISPYERGTSKKQFLHVAGLWLSATGGLSSMSSFLLGPLLFGLSFRESVASSLISVTIGCLIAAYCSIMGPQSGCRQMVTARYLFGWWFVKLVALASIIGVMGWSVVNSVVGGEMLAAISNDKVPLWVGIVIVTVCSFLVAIFGIKQVIKVETYLSVPVLTAFLLLYISSSDKYSFVNAYVSKGNLDSSTRKGNWMSFFSLCYSITATWGSITADYYILFPEDTPYIQIFCLTFFGTFLPTCFVGILGLLLASVAMSYKPWSVEYDSHGMGGLLWAGFQRWNGFGKFCVVVLVFSLVSNNIINTYSAAFSIQLSSVFCAKIPRWFWSIVCTIICLVCALIGRNHFSTILGNFLPMIGYWISMYFILLFEENLVFRRFFLHLYTKEFPTVTGEINGPELVGSSKEVEKDAVTNIHLLKRKHKVTKHRYNWDKWEDYEVLTHGYAATFAFIVGVAGVVVGMAQAYWIGPIAAKFGEYGGDVAMWLSMAFSGVVYPPCRYLELRKFGR"},{"created_at":"2011-05-26T18:08:56.000Z","updated_at":"2011-07-22T17:54:34.000Z","name":"Cytosine deaminase","uniprot_id":"Q12178","uniprot_name":"FCY1_YEAST","enzyme":true,"transporter":false,"gene_name":"FCY1","num_residues":158,"molecular_weight":"17506.90039","theoretical_pi":"5.73","general_function":"Involved in zinc ion binding","specific_function":"Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4","reactions":[{"id":1430,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2510,"direction":"\u003e","locations":"Cytoplasmic","altext":"Cytosine + H(2)O = uracil + NH(3).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1UAQ","cellular_location":"Cytoplasmic","genbank_gene_id":"AF005261","genbank_protein_id":"2343114","gene_card_id":"FCY1","chromosome_location":"chromosome 16","locus":"YPR062W","synonyms":["Cytosine aminohydrolase"],"enzyme_classes":["3.5.4.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"dCMP_cyt_deam_1","identifier":"PF00383"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGGTGACAGGGGGAATGGCAAGCAAGTGGGATCAGAAGGGTATGGACATTGCCTATGAGGAGGCGGCCTTAGGTTACAAAGAGGGTGGTGTTCCTATTGGCGGATGTCTTATCAATAACAAAGACGGAAGTGTTCTCGGTCGTGGTCACAACATGAGATTTCAAAAGGGTTCCGCCACACTACATGGTGAGATCTCCACTTTGGAAAACTGTGGGAGATTAGAGGGCAAAGTGTACAAAGATACCACTTTGTATACGACGCTGTCTCCATGCGACATGTGTACAGGTGCCATCATCATGTATGGTATTCCACGCTGTGTTGTCGGTGAGAACGTTAATTTCAAAAGTAAGGGCGAGAAATATTTACAAACTAGAGGTCACGAGGTTGTTGTTGTTGACGATGAGAGGTGTAAAAAGATCATGAAACAATTTATCGATGAAAGACCTCAGGATTGGTTTGAAGATATTGGTGAGTAG","protein_sequence":"MVTGGMASKWDQKGMDIAYEEAALGYKEGGVPIGGCLINNKDGSVLGRGHNMRFQKGSATLHGEISTLENCGRLEGKVYKDTTLYTTLSPCDMCTGAIIMYGIPRCVVGENVNFKSKGEKYLQTRGHEVVVVDDERCKKIMKQFIDERPQDWFEDIGE"},{"created_at":"2011-05-27T07:44:38.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"Purine-cytosine permease FCY21","uniprot_id":"P40039","uniprot_name":"FCY21_YEAST","enzyme":false,"transporter":true,"gene_name":"FCY21","num_residues":528,"molecular_weight":"58049.60156","theoretical_pi":"5.22","general_function":"Involved in nucleobase transmembrane transporter activity","specific_function":"Probable purine-cytosine permease","reactions":[],"signal_regions":"None","transmembrane_regions":"91-111;119-139;162-182;199-219;222-242;261-281;296-316;341-361;394-414;417-437;461-481;494-514","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"U18813","genbank_protein_id":"1381128","gene_card_id":"FCY21","chromosome_location":"chromosome 5","locus":"YER060W","synonyms":["PCP FCY21","Cytosine/purine transport protein FCY21","Fluorocytosine resistance protein 21"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity"},{"category":"Function","description":" nucleobase transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"}],"pfams":[{"name":"Transp_cyt_pur","identifier":"PF02133"}],"pathways":[],"gene_sequence":"ATGCCTCAAACGCACGAAATGTCCCTGAACGGCACTCAATACTTAAAATATGAACTTAAAGACCTTGAGTCTCGAGCTCACGATGCAAAGACTCCTTCAACAAATGAATTCTATGATGATGTAGAATCGCACGGAACAGAAGAATTAGTTGAAGCTAAACTGTCGTTTTTGAACAGAATTGCTGCTGGTTTAAGTGCCGAGACAAAGGGTATTGAACCGATTACAGAAGATGAAAAAACTGATGATTCTATACTGAACGCTGCATCTATGTGGTTTTCAGCAAATATGGTTCTGCCTGCTTATGCCATTGGCGCCCTAGGGCCTATGGTGTTTGATCTAAATTTCGGCCAAAGCGTTTTCGTTATTATTTTCTTTAACCTCTTAGGCTTGGTATCAGTTGCTTTCTTTTCTGTTTTCGGTGCAGAGCTGGGCCTAAGACAGATGATTTTGTCTAGATATTTAGTTGGCAATATCGCAGCCAGGATCTTCTCTTTCATCAATTTTATTGCCTGTATCGGTTGGGGTATCGTTAATACCGTAGCAAGCTCGCAAGTCCTGAATATGGTTAACCCCGGTCATCAATGTCCTCTCTGGGCTGGTTGTATAGTTATTATCGGTGCTACTGTAATTGTAACTTTTTTCGGCTATGGAGTCATTCATGCTTACGAGAAATGGGCGTGGGTACCAAATTTTGCCGTTTTTTTGGTAATAATTGCTCGTTTGGCAAGGTCTAAAAAATTTGTCCTTGGGGAGTGGACATCTGGTCCTACTACAGCAGGTAACGTGCTTTCATTTGGATCAACAGTTTATGGGTTTGCTGCAGGCTGGACAACATATGCGGCTGACTATACCGTTTATATGCCAAGGAAAACGAACAAGTATAAAATTTTTTTCTCGCTTGTAGTTGGGTTAGCAACACCATTATATTTTACTATGATACTTGGTGCAGCTGTAGCAATGGCAGCTATCGGCGATCCAGCCTGGAAGACGTATTATGACGAAAATTCCATAGGTGGTTTAACTTTTGCCGTTCTTGTCCCTAATTCTGTTCACGGATTCGGTCAGTTCTGTTGCGTGTTATTGTCTCTGTCCACTATCGCTAATAATGTTCCCAACATGTATACTATTGCTTTATCGGTGCAAGCCACGTGGGAACCTCTTGCGAAAGTCCCAAGAGTTATTTGGACTTTATTAGGCAATGCGGCCGCACTGGGTATTGCCATTCCTGCCTGCTACTATTTTTCTACCTTCATGAATTACTTCATGGATTCCATAGGTTATTATTTGGCTATTTATATTGCCATTGCATGTTCAGAGCATTTTATTTATAGGCGTTCCTTCAGTGCTTACAATGTTGATGATTGGGATAGTTGGGAACGTCTACCTATCGGCATTGCAGGTACTGCTGCCTTAATTGTTGGTGCCTTTGGCGTAGCGTTGGGTATGTGCCAAACTTATTGGGTTGGCGAGATCAGCCGTTTGATCGGAGACTACGGTGGTGATATTGGATTCGAGTTAGGACTAAGTTGGGCATTTATAGTTTACAACATTGCTAGACCCTTTGAGCTCAAGTACTTTGGTCGTTAA","protein_sequence":"MPQTHEMSLNGTQYLKYELKDLESRAHDAKTPSTNEFYDDVESHGTEELVEAKLSFLNRIAAGLSAETKGIEPITEDEKTDDSILNAASMWFSANMVLPAYAIGALGPMVFDLNFGQSVFVIIFFNLLGLVSVAFFSVFGAELGLRQMILSRYLVGNIAARIFSFINFIACIGWGIVNTVASSQVLNMVNPGHQCPLWAGCIVIIGATVIVTFFGYGVIHAYEKWAWVPNFAVFLVIIARLARSKKFVLGEWTSGPTTAGNVLSFGSTVYGFAAGWTTYAADYTVYMPRKTNKYKIFFSLVVGLATPLYFTMILGAAVAMAAIGDPAWKTYYDENSIGGLTFAVLVPNSVHGFGQFCCVLLSLSTIANNVPNMYTIALSVQATWEPLAKVPRVIWTLLGNAAALGIAIPACYYFSTFMNYFMDSIGYYLAIYIAIACSEHFIYRRSFSAYNVDDWDSWERLPIGIAGTAALIVGAFGVALGMCQTYWVGEISRLIGDYGGDIGFELGLSWAFIVYNIARPFELKYFGR"},{"created_at":"2011-05-27T07:47:40.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"Purine-cytosine permease FCY2","uniprot_id":"P17064","uniprot_name":"FCY2_YEAST","enzyme":false,"transporter":true,"gene_name":"FCY2","num_residues":533,"molecular_weight":"58200.69922","theoretical_pi":"4.86","general_function":"Involved in nucleobase transmembrane transporter activity","specific_function":"This permease has a broad specificity towards purines, and also transport cytosine and 5-methylcytosine but neither uracil nor thymine","reactions":[],"signal_regions":"None","transmembrane_regions":"99-119;122-141;199-218;257-276;301-320;348-367;399-418;466-485","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"U18813","genbank_protein_id":"603292","gene_card_id":"FCY2","chromosome_location":"chromosome 5","locus":"YER056C","synonyms":["PCP FCY2","Cytosine/purine transport protein FCY2","Fluorocytosine resistance protein 2"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity"},{"category":"Function","description":" nucleobase transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"}],"pfams":[{"name":"Transp_cyt_pur","identifier":"PF02133"}],"pathways":[],"gene_sequence":"ATGTTGGAAGAGGGAAATAATGTTTACGAAATCCAAGACTTGGAGAAGAGATCTCCTGTAATAGGCTCAAGCTTGGAAAACGAAAAGAAGGTAGCCGCTTCTGAAACTTTCACAGCAACTTCCGAAGATGACCAACAGTATATCGTTGAATCATCAGAGGCCACAAAATTATCGTGGTTCCATAAGTTCTTTGCCAGTTTGAATGCAGAAACAAAGGGTGTTGAACCAGTTACAGAGGATGAAAAAACGGACGATTCCATACTGAATGCTGCGTCCATGTGGTTTTCAGCTAATATGGTCATTGCATCATATGCTTTGGGTGCCTTAGGACCCATGGTGTTCGGTCTAAATTTTGGTCAAAGTGTTTTAGTTATCATATTTTTCAATATAATGGGGTTGATATTTGTTGCGTTCTTTTCTGTCTTTGGTGCAGAACTGGGCTTAAGACAGATGATTTTATCAAGATATCTGGTTGGTAATGTAACGGCAAGAATTTTCTCTCTTATTAACGTTATTGCTTGTGTCGGTTGGGGTATTGTGAATACCTCAGTATCCGCACAACTGCTGAATATGGTGAATGAAGGCTCCGGCCACGTCTGTCCTATTTGGGCCGGTTGTCTGATCATTATTGGTGGTACCGTGCTTGTGACTTTTTTTGGTTACAGTGTCATTCATGCATACGAGAAATGGTCATGGGTACCCAATTTTGCCGTCTTTTTGGTTATTATTGCCCAACTATCGAGATCAGGAAAGTTTAAAGGTGGTGAATGGGTAGGAGGTGCAACTACTGCAGGTAGTGTTCTTTCTTTTGGTTCATCTATTTTCGGTTTTGCCGCAGGATGGACGACCTATGCAGCTGACTACACTGTTTATATGCCAAAGAGTACAAACAAGTACAAGATTTTTTTCTCCCTAGTTGCTGGTCTAGCGTTCCCTCTATTTTTCACCATGATTCTTGGTGCTGCTTCTGCTATGGCTGCTCTTAATGACCCAACCTGGAAGGCATATTATGACAAAAATGCTATGGGTGGTGTCATATATGCTATCCTGGTTCCTAACTCTCTGAACGGATTTGGTCAATTCTGCTGCGTTTTGTTAGCTCTGTCCACTATTGCAAATAATATTCCAAATATGTATACTGTTGCTTTATCCGCTCAAGCTTTGTGGGCACCTTTGGCTAAAATACCAAGAGTAGTCTGGACAATGGCAGGTAATGCTGCCACTTTAGGTATTTCCATCCCTGCTACCTATTACTTTGATGGCTTTATGGAGAATTTCATGGATTCTATCGGTTACTACTTAGCTATTTACATTGCCATCTCATGTTCAGAACATTTCTTCTACAGACGTTCCTTCAGTGCTTACAATATTGATGATTGGGATAATTGGGAGCATCTACCTATCGGTATCGCAGGTACTGCTGCCTTAATTGTTGGTGCCTTCGGTGTTGCATTGGGTATGTGTCAAACCTATTGGGTTGGTGAAATTGGCCGCTTAATTGGTAAATATGGTGGTGACATTGGGTTCGAGTTGGGTGCAAGTTGGGCCTTCATCATCTACAACATCTTAAGACCTTTAGAATTAAAATACTTCGGTCGTTAG","protein_sequence":"MLEEGNNVYEIQDLEKRSPVIGSSLENEKKVAASETFTATSEDDQQYIVESSEATKLSWFHKFFASLNAETKGVEPVTEDEKTDDSILNAASMWFSANMVIASYALGALGPMVFGLNFGQSVLVIIFFNIMGLIFVAFFSVFGAELGLRQMILSRYLVGNVTARIFSLINVIACVGWGIVNTSVSAQLLNMVNEGSGHVCPIWAGCLIIIGGTVLVTFFGYSVIHAYEKWSWVPNFAVFLVIIAQLSRSGKFKGGEWVGGATTAGSVLSFGSSIFGFAAGWTTYAADYTVYMPKSTNKYKIFFSLVAGLAFPLFFTMILGAASAMAALNDPTWKAYYDKNAMGGVIYAILVPNSLNGFGQFCCVLLALSTIANNIPNMYTVALSAQALWAPLAKIPRVVWTMAGNAATLGISIPATYYFDGFMENFMDSIGYYLAIYIAISCSEHFFYRRSFSAYNIDDWDNWEHLPIGIAGTAALIVGAFGVALGMCQTYWVGEIGRLIGKYGGDIGFELGASWAFIIYNILRPLELKYFGR"},{"created_at":"2011-05-27T07:49:02.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"Purine-cytosine permease FCY22","uniprot_id":"Q12119","uniprot_name":"FCY22_YEAST","enzyme":false,"transporter":true,"gene_name":"FCY22","num_residues":530,"molecular_weight":"57326.69922","theoretical_pi":"4.84","general_function":"Involved in nucleobase transmembrane transporter activity","specific_function":"Probable purine-cytosine permease","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;119-139;162-182;197-217;220-240;263-283;298-318;345-365;372-392;396-416;418-438;463-483","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"U18813","genbank_protein_id":"1381130","gene_card_id":"FCY22","chromosome_location":"chromosome 5","locus":"YER060W-A","synonyms":["PCP FCY22","Cytosine/purine transport protein FCY22","Fluorocytosine resistance protein 22"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity"},{"category":"Function","description":" nucleobase transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Process","description":" transport"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"}],"pfams":[{"name":"Transp_cyt_pur","identifier":"PF02133"}],"pathways":[],"gene_sequence":"ATGCCAGAAAAGTTAGCCATGTCAATGGTCGATATAAAAGATGCGGGGAGTGAACTAAGGGACCTCGAATCTGGAGCTCTGGACACAAAATCTTCCGCCGCTGATGTATACTATGAGGGTGTAGAATTGCATAGAACCAACGAATTCATTGATAATAAGCCGTCCTTTTTCAATAGGATTGCAGCTGCTTTAAATGCTGAGACGAAAGGTATTGAACCAGTTACAGAAGATGAAAAAAATGATGACTCGATACTCAATGCCGCCACTATATGGTTTTCAGCTAATATGGTGATTGTAGCCTATTCCGTAGGTGCCTTGGGTCCTCTAGTATTTGGCCTAAATTTCGGCCAAAGTGTTTTAGTTATCATTTTTTTCAATATTTTGGGTTTGATCCCTGTTGCATTATTCTCACTTTTTGGGGTAGAACTGGGCCTAAGACAGATGATTCTATCGAGATATTTGGCTGGTAACATCACAGCAAGATTTTTCTCTCTTGTTAATGTCATTGCTTGTGTCGGTTGGTGTGTTTTAAATATTTCTGTTTCTGCTCAACTTTTGAATATGGTGAATGAAGGCTCTGGGCACAACTGTCCTATTTGGGCAGGTTGTTTGATTATTGCTGGTGGTACCGTGCTTGTGACTTTTTTTGGTTACAGTGTCGTTCATGCATACGAAAAATGGTCGTGGGTACCCAATTTTGCTGCCTTTTTGGTCATTATTGCCCAACTATCGAGATCAGGAAAATTTAAAGGTGGTGAATGGGTAGGGGGTGCAACTACTGCAGGTGGTGTTCTTTCTTTTGGTTCATCTGTTTTTGGGTCAGCTGCGGGTTGGGCGACTTATGCAGCAGATTACACTGTTTATATGCCAAAGACCACAAGTAAATACAAAATTTTTTTTTCCGTAGTAGCCGGTCTAGCGTTCCCTCTATTTTTCACCATGATTCTTGGTGCTGCTTGCGGTATGGCGGCCCTTAATGACCCAACCTGGAAGTCATATTATGATAAAAACGCCATGGGTGGTGTCATATATGCTATCCTGGTCCCTAACTCTCTAAACGGATTCGGTCAATTCTGCTGTGTTTTGTTGGCTCTTTCAACTGTTGCTAATAATGTCCCTGGAATGTACACTGTCGCTTTATCCGCTCAAGCTTTGTGGGCACCTTTGGCTAAAATACCAAGAGTAGTCTGGACAATGGCAGGTAATGCTGCCACTTTAGGTATTTCCATCCCTGCTACCTATTACTTTGACGGCTTTATGGAGAATTTTATGGATTCCATTGGTTATTATTTGGCTATTTATATTGCCATTGCATGTTCAGAGCATTTTATTTATAGGCGTTCCTTCAGTGCTTACAATATTGATGATTGGGATAATTGGGAGCATCTACCTATCGGTATCGCAGGTACTGCTGCCTTAATTGCTGGTGCCTTTGGAGTAGCGTTGGGTATGTGCCAAACTTATTGGGTTGGTGAGATCAGTCGTTTGATCGGAGAGTACGGCGGTGACATTGGGTTCGAGTTAGGCGGAAGTTGGGCGTTCATCATCTATAACATTGTAAGACCTTTAGAACTCAAATATTTCGGTCGATGA","protein_sequence":"MPEKLAMSMVDIKDAGSELRDLESGALDTKSSAADVYYEGVELHRTNEFIDNKPSFFNRIAAALNAETKGIEPVTEDEKNDDSILNAATIWFSANMVIVAYSVGALGPLVFGLNFGQSVLVIIFFNILGLIPVALFSLFGVELGLRQMILSRYLAGNITARFFSLVNVIACVGWCVLNISVSAQLLNMVNEGSGHNCPIWAGCLIIAGGTVLVTFFGYSVVHAYEKWSWVPNFAAFLVIIAQLSRSGKFKGGEWVGGATTAGGVLSFGSSVFGSAAGWATYAADYTVYMPKTTSKYKIFFSVVAGLAFPLFFTMILGAACGMAALNDPTWKSYYDKNAMGGVIYAILVPNSLNGFGQFCCVLLALSTVANNVPGMYTVALSAQALWAPLAKIPRVVWTMAGNAATLGISIPATYYFDGFMENFMDSIGYYLAIYIAIACSEHFIYRRSFSAYNIDDWDNWEHLPIGIAGTAALIAGAFGVALGMCQTYWVGEISRLIGEYGGDIGFELGGSWAFIIYNIVRPLELKYFGR"}]}