{"ymdb_id":"YMDB00631","created_at":"2011-05-29T18:37:47.000Z","updated_at":"2016-09-08T18:35:42.000Z","name":"geranylgeranyl diphosphate","cas":"6699-20-3","state":null,"melting_point":null,"description":"Geranylgeranyl diphosphate is a prenol lipid, specifically an isoprenoid-disphosphate. Prenol lipids are synthesized from the 5-carbon precursors isopentenyl diphosphate and dimethylallyl diphosphate that are produced mainly via the mevalonic acid pathway. Simple isoprenoids like Geranylgeranyl diphosphate are formed by the successive addition of C5 units.[Wikipedia]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"lipid particle","synthesis_reference":null,"chebi_id":"15831","hmdb_id":null,"kegg_id":"C00353","pubchem_id":"6420192","cs_id":"23092869","foodb_id":null,"wikipedia_link":"geranylgeranyl_diphosphate","biocyc_id":null,"iupac":"{[hydroxy({[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]oxy})phosphoryl]oxy}phosphonic acid","traditional_iupac":"geranylgeranyl diphosphate","logp":"5.276447335666666","pka":"3.2043406094078315","alogps_solubility":"4.63e-03 g/l","alogps_logp":"3.57","alogps_logs":"-4.99","acceptor_count":"5","donor_count":"3","rotatable_bond_count":"14","polar_surface_area":"113.28999999999999","refractivity":"120.5331","polarizability":"47.8204807988394","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":null,"pka_strongest_acidic":"1.7672186885241006","bioavailability":"0","number_of_rings":"0","rule_of_five":"0","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["all-trans-geranylgeranyl diphosphate","all-trans-geranylgeranyl pyrophosphate","geranylgeranyl pyrophosphate","ggpp"],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":7665600,"citation":"Jiang, Y., Proteau, P., Poulter, D., Ferro-Novick, S. (1995). \"BTS1 encodes a geranylgeranyl diphosphate synthase in Saccharomyces cerevisiae.\" J Biol Chem 270:21793-21799."},{"pubmed_id":9858571,"citation":"Sato, M., Sato, K., Nishikawa, S., Hirata, A., Kato, J., Nakano, A. (1999). \"The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis.\" Mol Cell Biol 19:471-483."},{"pubmed_id":12702274,"citation":"Grabinska, K., Palamarczyk, G. (2002). \"Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase.\" FEMS Yeast Res 2:259-265."}],"proteins":[{"created_at":"2011-05-26T18:23:57.000Z","updated_at":"2011-07-22T17:54:42.000Z","name":"Geranylgeranyl pyrophosphate synthase","uniprot_id":"Q12051","uniprot_name":"GGPPS_YEAST","enzyme":true,"transporter":false,"gene_name":"BTS1","num_residues":335,"molecular_weight":"38651.0","theoretical_pi":"6.04","general_function":"Involved in isoprenoid biosynthetic process","specific_function":"Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting","reactions":[{"id":1484,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2529,"direction":"\u003e","locations":"Cytoplasm","altext":"Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2530,"direction":"\u003e","locations":"Cytoplasm","altext":"Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2531,"direction":"\u003e","locations":"Cytoplasm","altext":"Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692852","genbank_protein_id":"51013155","gene_card_id":"BTS1","chromosome_location":"chromosome 16","locus":"YPL069C","synonyms":["GGPP synthase","GGPPSase","BET2 suppressor protein 1","Geranylgeranyl diphosphate synthase","Dimethylallyltranstransferase","Geranyltranstransferase","Farnesyltranstransferase"],"enzyme_classes":["2.5.1.1","2.5.1.29","2.5.1.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" isoprenoid metabolic process"},{"category":"Process","description":" isoprenoid biosynthetic process"}],"pfams":[{"name":"polyprenyl_synt","identifier":"PF00348"}],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"}],"gene_sequence":"ATGGAGGCCAAGATAGATGAGCTGATCAATAATGATCCTGTTTGGTCCAGCCAAAATGAAAGCTTGATTTCAAAACCTTATAATCACATCCTTTTGAAACCTGGCAAGAACTTTAGACTAAATTTAATAGTTCAAATTAACAGAGTTATGAATTTGCCCAAAGACCAGCTGGCCATAGTTTCGCAAATTGTTGAGCTCTTGCATAATTCCAGCCTTTTAATCGACGATATAGAAGATAATGCTCCCTTGAGAAGGGGACAGACCACTTCTCACTTAATCTTCGGTGTACCCTCCACTATAAACACCGCAAATTATATGTATTTCAGAGCCATGCAACTTGTATCGCAGCTAACCACAAAAGAGCCTTTGTATCATAATTTGATTACGATTTTCAACGAAGAATTGATCAATCTACATAGGGGACAAGGCTTGGATATATACTGGAGAGACTTTCTGCCTGAAATCATACCTACTCAGGAGATGTATTTGAATATGGTTATGAATAAAACAGGCGGCCTTTTCAGATTAACGTTGAGACTCATGGAAGCGCTGTCTCCTTCCTCACACCACGGCCATTCGTTGGTTCCTTTCATAAATCTTCTGGGTATTATTTATCAGATTAGAGATGATTACTTGAATTTGAAAGATTTCCAAATGTCCAGCGAAAAAGGCTTTGCTGAGGACATTACAGAGGGGAAGTTATCTTTTCCCATCGTCCACGCCCTTAACTTCACTAAAACGAAAGGTCAAACTGAGCAACACAATGAAATTCTAAGAATTCTCCTGTTGAGGACAAGTGATAAAGATATAAAACTAAAGCTGATTCAAATACTGGAATTCGACACCAATTCATTGGCCTACACCAAAAATTTTATTAATCAATTAGTGAATATGATAAAAAATGATAATGAAAATAAGTATTTACCTGATTTGGCTTCGCATTCCGACACCGCCACCAATTTACATGACGAATTGTTATATATAATAGACCACTTATCCGAATTGTGA","protein_sequence":"MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLPDLASHSDTATNLHDELLYIIDHLSEL"},{"created_at":"2011-05-27T03:49:37.000Z","updated_at":"2011-07-22T17:54:30.000Z","name":"Putative dehydrodolichyl diphosphate synthase","uniprot_id":"Q03175","uniprot_name":"SRT1_YEAST","enzyme":true,"transporter":false,"gene_name":"SRT1","num_residues":343,"molecular_weight":"40199.69922","theoretical_pi":"10.03","general_function":"Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups","specific_function":"Could be a cis-prenyl transferase that adds multiple copies of isopentenyl pyrophosphate (ipp) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (DeDol- PP)","reactions":[{"id":1392,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1393,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1394,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1395,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1396,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1397,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1398,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1399,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1400,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1401,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1402,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1403,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1404,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1405,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1406,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1407,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1408,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1409,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1410,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14431,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006945","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AB013498","genbank_protein_id":"4126459","gene_card_id":"SRT1","chromosome_location":"chromosome 13","locus":"YMR101C","synonyms":["DEDOL-PP synthase"],"enzyme_classes":["2.5.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Prenyltransf","identifier":"PF01255"}],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"}],"gene_sequence":"ATGAAAATGCCCAGTATTATTCAGATTCAGTTTGTAGCCCTAAAAAGGCTTTTGGTAGAAACCAAAGAACAGATGTGCTTCGCAGTGAAAAGTATATTTCAGAGAGTATTTGCGTGGGTTATGTCATTAAGCTTGTTTTCATGGTTTTATGTAAATCTTCAGAATATTTTGATAAAAGCATTAAGGGTAGGGCCAGTGCCTGAACATGTCTCCTTTATCATGGATGGTAACCGGAGATATGCCAAGTCAAGAAGGCTACCAGTAAAAAAAGGCCATGAAGCTGGTGGGTTAACGTTACTAACACTACTGTATATCTGCAAAAGATTGGGTGTAAAATGTGTTTCCGCCTATGCATTTTCTATTGAAAATTTTAATAGACCAAAAGAAGAAGTAGATACGCTAATGAATTTGTTTACGGTAAAGCTTGATGAATTCGCAAAAAGAGCCAAGGACTATAAGGATCCCTTATACGGATCTAAAATAAGAATAGTAGGTGATCAATCTTTACTATCTCCAGAAATGAGAAAAAAAATTAAAAAAGTGGAAGAAATCACACAGGATGGAGACGATTTCACTTTATTTATATGTTTTCCTTACACTTCAAGAAATGATATGTTACATACTATTCGTGATTCAGTTGAAGACCATTTGGAAAATAAATCACCAAGGATTAATATAAGAAAATTTACTAATAAAATGTACATGGGTTTCCATTCCAATAAATGTGAATTATTAATCAGAACAAGTGGGCATAGGAGGCTCTCAGACTATATGCTATGGCAAGTACATGAAAATGCCACCATTGAATTTAGTGATACGTTGTGGCCAAATTTTAGCTTCTTTGCTATGTACCTGATGATTCTCAAATGGTCCTTCTTTTCCACCATTCAAAAATATAATGAGAAGAATCACTCATTGTTTGAAAAAATACATGAAAGCGTTCCTTCAATATTTAAAAAAAAGAAAACAGCTATGTCTTTGTACAACTTTCCAAACCCCCCCATTTCAGTTTCGGTTACAGGAGATGAATAA","protein_sequence":"MKMPSIIQIQFVALKRLLVETKEQMCFAVKSIFQRVFAWVMSLSLFSWFYVNLQNILIKALRVGPVPEHVSFIMDGNRRYAKSRRLPVKKGHEAGGLTLLTLLYICKRLGVKCVSAYAFSIENFNRPKEEVDTLMNLFTVKLDEFAKRAKDYKDPLYGSKIRIVGDQSLLSPEMRKKIKKVEEITQDGDDFTLFICFPYTSRNDMLHTIRDSVEDHLENKSPRINIRKFTNKMYMGFHSNKCELLIRTSGHRRLSDYMLWQVHENATIEFSDTLWPNFSFFAMYLMILKWSFFSTIQKYNEKNHSLFEKIHESVPSIFKKKKTAMSLYNFPNPPISVSVTGDE"},{"created_at":"2011-05-27T03:50:01.000Z","updated_at":"2011-07-22T17:54:30.000Z","name":"Dehydrodolichyl diphosphate synthase","uniprot_id":"P35196","uniprot_name":"RER2_YEAST","enzyme":true,"transporter":false,"gene_name":"RER2","num_residues":286,"molecular_weight":"32693.30078","theoretical_pi":"7.91","general_function":"Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups","specific_function":"Cis-prenyl transferase that adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP)","reactions":[{"id":1392,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1393,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1394,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1395,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1396,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1397,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1398,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1399,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1400,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1401,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1402,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1403,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1404,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1405,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1406,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14431,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006945","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Peripheral membrane protein","genbank_gene_id":"AB013497","genbank_protein_id":"4126457","gene_card_id":"RER2","chromosome_location":"chromosome 2","locus":"YBR002C","synonyms":["DEDOL-PP synthase"],"enzyme_classes":["2.5.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Prenyltransf","identifier":"PF01255"}],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"}],"gene_sequence":"ATGGAAACGGATAGTGGTATACCTGGTCATTCATTTGTGTTAAAGTGGACAAAAAACATCTTTTCGCGCACATTGCGTGCATCTAACTGTGTACCTAGACATGTTGGGTTCATCATGGATGGGAACAGGAGATTCGCTAGAAAGAAAGAGATGGACGTAAAGGAGGGCCACGAGGCAGGATTTGTTAGTATGAGTAGAATCTTAGAACTGTGTTATGAAGCAGGAGTCGATACGGCTACCGTGTTTGCCTTTTCAATTGAAAATTTCAAGAGGAGCTCACGGGAAGTTGAATCACTGATGACTTTAGCGCGCGAAAGGATACGACAAATCACAGAACGTGGAGAGCTGGCCTGTAAGTATGGGGTACGCATTAAAATTATCGGCGATCTCTCTTTGTTGGATAAGTCTCTATTAGAAGATGTTCGGGTTGCTGTGGAAACTACAAAGAACAACAAAAGGGCCACGTTAAATATCTGCTTTCCATATACAGGCAGGGAAGAAATCTTGCATGCCATGAAAGAAACAATTGTTCAACATAAGAAGGGCGCCGCTATAGACGAAAGCACGTTAGAATCGCATCTCTACACGGCGGGGGTACCCCCTTTAGATTTATTGATTAGGACAAGTGGCGTTTCCAGATTAAGTGACTTTTTGATATGGCAGGCATCGAGTAAGGGCGTACGCATCGAATTGCTGGATTGTTTATGGCCAGAGTTTGGACCTATACGGATGGCATGGATTTTATTAAAATTTTCGTTTCACAAATCCTTTTTAAACAAAGAGTACAGATTAGAGGAAGGTGATTATGACGAGGAAACCAATGGGGACCCCATCGATTTGAAAGAAAAAAAGTTGAATTAA","protein_sequence":"METDSGIPGHSFVLKWTKNIFSRTLRASNCVPRHVGFIMDGNRRFARKKEMDVKEGHEAGFVSMSRILELCYEAGVDTATVFAFSIENFKRSSREVESLMTLARERIRQITERGELACKYGVRIKIIGDLSLLDKSLLEDVRVAVETTKNNKRATLNICFPYTGREEILHAMKETIVQHKKGAAIDESTLESHLYTAGVPPLDLLIRTSGVSRLSDFLIWQASSKGVRIELLDCLWPEFGPIRMAWILLKFSFHKSFLNKEYRLEEGDYDEETNGDPIDLKEKKLN"},{"created_at":"2011-05-27T04:12:21.000Z","updated_at":"2011-05-27T15:01:22.000Z","name":"Geranylgeranyl transferase type-1 subunit beta","uniprot_id":"P18898","uniprot_name":"PGTB1_YEAST","enzyme":true,"transporter":false,"gene_name":"CDC43","num_residues":376,"molecular_weight":"42689.10156","theoretical_pi":"6.31","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal sequence Cys-Ile-Ile-Leu or Cys-Val-Leu-Leu. Acts, among other substrates, on Rho1 and Rho2 and CDC42 proteins. Participates in a RAS-like C-terminal modification of proteins involved in nuclear division and bud growth. It is involved in bud positioning and cell polarity","reactions":[{"id":2760,"direction":"\u003e","locations":"","altext":"Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M74109","genbank_protein_id":"171147","gene_card_id":"CDC43","chromosome_location":"chromosome 7","locus":"YGL155W","synonyms":["Cell division cycle protein 43","Geranylgeranyl transferase type I subunit beta","GGTase-I-beta","RAS proteins geranylgeranyltransferase subunit beta","Type I protein geranyl-geranyltransferase subunit beta","PGGT"],"enzyme_classes":["2.5.1.59"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Prenyltrans","identifier":"PF00432"}],"pathways":[],"gene_sequence":"ATGTGTCAAGCTACCAATGGCCCGAGTAGAGTTGTGACTAAAAAGCATAGGAAATTTTTCGAAAGACATCTACAGTTGCTTCCCTCTTCACATCAGGGACATGACGTGAACAGAATGGCGATAATATTCTACTCAATCTCAGGACTCTCTATATTTGATGTTAACGTTTCTGCGAAGTACGGCGATCATCTTGGCTGGATGCGCAAACATTATATCAAAACAGTGCTGGATGATACAGAAAATACTGTGATATCTGGATTTGTTGGAAGCTTAGTCATGAATATCCCTCACGCAACAACGATTAATCTACCAAATACTCTCTTTGCATTGTTGTCCATGATTATGCTGAGAGATTACGAGTATTTTGAGACTATACTAGACAAAAGAAGCCTGGCGAGATTTGTTTCTAAGTGCCAACGACCTGACCGTGGCTCGTTTGTATCTTGTTTAGACTATAAGACAAATTGTGGATCTTCGGTTGATTCAGACGATTTAAGGTTTTGCTACATCGCAGTTGCCATTCTGTACATATGCGGATGCCGATCCAAAGAAGACTTTGATGAATACATTGATACTGAGAAGTTGCTTGGCTATATAATGTCGCAACAATGCTACAACGGAGCTTTCGGTGCCCACAATGAACCACACTCAGGGTACACATCTTGTGCGCTGTCTACCTTAGCTTTACTCTCTAGTTTGGAAAAGCTATCAGACAAGTTTAAAGAAGACACCATAACCTGGCTATTACATAGGCAAGTATCAAGCCATGGATGTATGAAATTTGAAAGCGAATTGAATGCCAGCTATGATCAATCTGATGATGGCGGTTTCCAGGGAAGGGAGAACAAGTTCGCTGATACGTGTTACGCATTTTGGTGCTTAAATTCACTACACTTACTAACAAAGGATTGGAAAATGCTATGCCAAACTGAACTAGTCACAAATTATTTGCTTGATCGAACGCAAAAAACATTAACTGGAGGCTTTAGTAAAAATGACGAAGAAGATGCTGATTTATATCACAGCTGTCTAGGGAGCGCTGCGTTAGCATTAATTGAGGGGAAATTTAATGGAGAATTATGCATACCTCAAGAAATATTTAATGATTTTAGTAAAAGGTGCTGTTTTTGA","protein_sequence":"MCQATNGPSRVVTKKHRKFFERHLQLLPSSHQGHDVNRMAIIFYSISGLSIFDVNVSAKYGDHLGWMRKHYIKTVLDDTENTVISGFVGSLVMNIPHATTINLPNTLFALLSMIMLRDYEYFETILDKRSLARFVSKCQRPDRGSFVSCLDYKTNCGSSVDSDDLRFCYIAVAILYICGCRSKEDFDEYIDTEKLLGYIMSQQCYNGAFGAHNEPHSGYTSCALSTLALLSSLEKLSDKFKEDTITWLLHRQVSSHGCMKFESELNASYDQSDDGGFQGRENKFADTCYAFWCLNSLHLLTKDWKMLCQTELVTNYLLDRTQKTLTGGFSKNDEEDADLYHSCLGSAALALIEGKFNGELCIPQEIFNDFSKRCCF"},{"created_at":"2011-05-27T04:18:47.000Z","updated_at":"2011-05-27T15:01:22.000Z","name":"Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha","uniprot_id":"P29703","uniprot_name":"FNTA_YEAST","enzyme":true,"transporter":false,"gene_name":"RAM2","num_residues":316,"molecular_weight":"37507.30078","theoretical_pi":"4.75","general_function":"Involved in protein prenyltransferase activity","specific_function":"Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate","reactions":[{"id":2761,"direction":"\u003e","locations":"","altext":"Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2760,"direction":"\u003e","locations":"","altext":"Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M88584","genbank_protein_id":"172359","gene_card_id":"RAM2","chromosome_location":"chromosome 11","locus":"YKL019W","synonyms":["CAAX farnesyltransferase subunit alpha","FTase-alpha","Ras proteins prenyltransferase subunit alpha","Type I protein geranyl-geranyltransferase subunit alpha","GGTase-I-alpha"],"enzyme_classes":["2.5.1.58","2.5.1.59"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" prenyltransferase activity"},{"category":"Function","description":" protein prenyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" protein amino acid lipidation"},{"category":"Process","description":" protein prenylation"},{"category":"Process","description":" protein amino acid prenylation"}],"pfams":[{"name":"PPTA","identifier":"PF01239"}],"pathways":[],"gene_sequence":"ATGGAGGAGTACGATTATTCAGACGTTAAACCTTTGCCCATTGAGACAGACTTGCAGGATGAACTGTGCAGGATTATGTATACCGAGGATTATAAGCGGTTGATGGGACTCGCAAGGGCTCTGATCAGCCTTAACGAACTGTCACCCAGGGCACTACAGCTAACAGCCGAAATTATCGACGTGGCGCCAGCCTTCTACACCATATGGAACTACCGATTCAATATCGTCAGGCACATGATGAGTGAATCCGAAGACACTGTCTTGTACCTGAACAAGGAATTAGACTGGCTAGATGAAGTTACGCTGAATAATCCAAAGAACTATCAGATCTGGTCCTATAGACAGTCTCTTTTGAAGCTACATCCGTCTCCTTCCTTCAAAAGAGAGCTGCCTATCTTAAAACTGATGATTGATGATGATTCCAAGAATTATCACGTTTGGTCGTACAGAAAGTGGTGCTGTTTGTTCTTCAGTGACTTTCAACATGAGCTCGCCTACGCCAGCGACCTCATCGAGACAGACATTTATAACAACAGCGCATGGACTCATAGGATGTTTTACTGGGTGAACGCTAAAGATGTCATTTCAAAAGTGGAATTGGCCGACGAGCTCCAGTTCATTATGGACAAGATTCAATTGGTTCCGCAGAACATCAGTCCGTGGACCTACCTCCGTGGTTTCCAAGAGCTATTCCATGATAGGCTACAGTGGGATAGCAAAGTAGTCGACTTCGCCACAACCTTCATCGGTGACGTATTGTCACTTCCAATTGGCTCACCAGAGGATTTGCCCGAGATCGAGTCCTCATATGCCCTGGAATTCCTGGCATATCACTGGGGGGCAGACCCTTGTACCCGAGACAACGCTGTTAAGGCCTATAGCTTGCTAGCAATCAAATACGATCCTATTAGAAAAAACTTGTGGCACCACAAAATAAATAATCTGAACTGA","protein_sequence":"MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIIDVAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKLHPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSAWTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSKVVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKYDPIRKNLWHHKINNLN"},{"created_at":"2011-05-27T04:49:38.000Z","updated_at":"2011-05-27T15:01:23.000Z","name":"Geranylgeranyl transferase type-2 subunit beta","uniprot_id":"P20133","uniprot_name":"PGTB2_YEAST","enzyme":true,"transporter":false,"gene_name":"BET2","num_residues":325,"molecular_weight":"36665.60156","theoretical_pi":"4.81","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4","reactions":[{"id":2760,"direction":"\u003e","locations":"","altext":"Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558067","genbank_protein_id":"45270024","gene_card_id":"BET2","chromosome_location":"chromosome 16","locus":"YPR176C","synonyms":["Geranylgeranyl transferase type II subunit beta","GGTase-II-beta","Type II protein geranyl-geranyltransferase subunit beta","PGGT","YPT1/SEC4 proteins geranylgeranyltransferase subunit beta"],"enzyme_classes":["2.5.1.60"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Prenyltrans","identifier":"PF00432"}],"pathways":[],"gene_sequence":"ATGTCAGGATCTCTTACGCTACTTAAGGAAAAGCATATACGTTATATTGAATCATTGGATACAAAGAAGCATAATTTTGAATACTGGCTTACCGAGCATCTTCGTTTGAATGGGATATATTGGGGACTTACTGCCTTGTGTGTGCTTGATTCTCCAGAGACATTTGTGAAAGAAGAGGTTATATCATTTGTTCTGAGCTGTTGGGACGACAAATACGGCGCTTTCGCACCATTTCCAAGACATGATGCACATTTATTAACTACATTGTCCGCCGTACAGATCTTGGCCACTTATGATGCTTTGGATGTTCTTGGAAAAGATCGTAAGGTTCGCTTGATTTCCTTCATCCGTGGGAATCAATTGGAAGATGGTTCGTTCCAGGGTGACAGGTTTGGGGAGGTAGATACAAGGTTTGTTTATACAGCCTTGAGTGCACTATCAATTTTGGGTGAATTAACGTCTGAAGTTGTTGACCCTGCTGTAGACTTTGTACTCAAGTGTTATAATTTTGATGGTGGCTTTGGATTATGTCCTAATGCTGAATCCCATGCAGCTCAAGCTTTTACCTGTCTTGGCGCTTTGGCAATTGCTAACAAATTGGATATGCTTAGTGACGACCAACTAGAAGAAATTGGGTGGTGGCTTTGCGAACGACAATTACCAGAAGGTGGACTAAACGGTAGGCCAAGTAAACTGCCCGATGTTTGCTATAGTTGGTGGGTTTTATCTTCATTAGCTATTATTGGTAGACTAGATTGGATAAATTATGAGAAGCTAACTGAGTTTATACTCAAATGTCAAGATGAGAAGAAGGGTGGAATAAGCGACAGGCCTGAAAATGAAGTGGATGTCTTCCATACAGTTTTTGGTGTTGCTGGTTTAAGTTTAATGGGATACGACAATTTAGTCCCCATAGATCCCATATATTGTATGCCGAAATCCGTTACATCAAAATTCAAAAAGTATCCATACAAATAG","protein_sequence":"MSGSLTLLKEKHIRYIESLDTKKHNFEYWLTEHLRLNGIYWGLTALCVLDSPETFVKEEVISFVLSCWDDKYGAFAPFPRHDAHLLTTLSAVQILATYDALDVLGKDRKVRLISFIRGNQLEDGSFQGDRFGEVDTRFVYTALSALSILGELTSEVVDPAVDFVLKCYNFDGGFGLCPNAESHAAQAFTCLGALAIANKLDMLSDDQLEEIGWWLCERQLPEGGLNGRPSKLPDVCYSWWVLSSLAIIGRLDWINYEKLTEFILKCQDEKKGGISDRPENEVDVFHTVFGVAGLSLMGYDNLVPIDPIYCMPKSVTSKFKKYPYK"},{"created_at":"2011-05-29T04:09:38.000Z","updated_at":"2011-05-29T05:06:53.000Z","name":"Geranylgeranyl transferase type-2 subunit alpha","uniprot_id":"Q00618","uniprot_name":"PGTA_YEAST","enzyme":true,"transporter":false,"gene_name":"BET4","num_residues":327,"molecular_weight":"39674.30078","theoretical_pi":"7.27","general_function":"Involved in protein prenyltransferase activity","specific_function":"Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4","reactions":[{"id":2760,"direction":"\u003e","locations":"","altext":"Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"BET4","chromosome_location":"chromosome 10","locus":"YJL031C","synonyms":["GGTase-II-alpha","Geranylgeranyl transferase type II subunit alpha","PGGT","Type II protein geranyl-geranyltransferase subunit alpha","YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha"],"enzyme_classes":["2.5.1.60"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" prenyltransferase activity"},{"category":"Function","description":" protein prenyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" protein amino acid lipidation"},{"category":"Process","description":" protein prenylation"},{"category":"Process","description":" protein amino acid prenylation"}],"pfams":[{"name":"PPTA","identifier":"PF01239"}],"pathways":[],"gene_sequence":"ATGGTATGTGCACTTCAAATGTTCGTTACATTATGAATTCTTTTTTTTACTGACTACCAAGCAATTTTTTATATTTGCCACATTAAACAGCATGGCATTAAAAGGAAACAGTGGACCAAGGAATTACTGAGACAAAAGAGAGTTCAAGACGAAAAGAAAATATATGATTATAGAAGCTTGACTGAAAATGTTTTGAATATGAGAGATGAAAAAATTTACTCAATTGAAGCTCTGAAGAAAACATCAGAACTTCTTGAGAAAAATCCGGAATTTAATGCTATTTGGAATTACAGAAGGGATATTATAGCGAGTTTGGCTTCTGAGTTGGAAATACCTTTCTGGGATAAAGAGTTAGTTTTTGTAATGATGCTATTGAAGGATTACCCCAAAGTCTATTGGATATGGAATCACAGACTTTGGGTCTTGAAACATTATCCTACGAGTTCCCCTAAAGTGTGGCAAACTGAACTTGCTGTCGTGAATAAGTTATTGGAACAAGATGCAAGAAATTACCACGGATGGCATTACCGCAGAATAGTTGTTGGTAACATAGAGAGTATCACTAATAAAAGTCTTGACAAGGAGGAGTTTGAATACACAACAATAAAGATTAACAATAACATTTCAAATTATTCTGCATGGCACCAAAGAGTACAGATCATAAGCAGAATGTTTCAGAAAGGAGAGGTTGGGAATCAAAAGGAGTATATTCGGACTGAAATATCTTATATCATCAACGCTATGTTTACCGACGCCGAAGACCAATCCGTATGGTTTTATATCAAGTGGTTCATTAAAAACGACATTGTTTGTAAAACTCTGGACGAACAAGAGTACCTTAAAATGTTGAAAGACTTGAGAGAAAACATTCTGTTAATAAATAATGACGAAATTGAATTTTCCGGGAAGCAAAATATTTGGTGCTTGAAAATTTTATTAGTTCTCGAAGATATTCTGGAAGAAAAGGAAGCTCTAACGGAAAGAAGCTCGGAACAATATTTGGTCCAATTAATAGATGCGGATCCGTTAAGAAAGAATAGATACCTACATCTCCTGGAGCAGCATAAGTGA","protein_sequence":"MHGIKRKQWTKELLRQKRVQDEKKIYDYRSLTENVLNMRDEKIYSIEALKKTSELLEKNPEFNAIWNYRRDIIASLASELEIPFWDKELVFVMMLLKDYPKVYWIWNHRLWVLKHYPTSSPKVWQTELAVVNKLLEQDARNYHGWHYRRIVVGNIESITNKSLDKEEFEYTTIKINNNISNYSAWHQRVQIISRMFQKGEVGNQKEYIRTEISYIINAMFTDAEDQSVWFYIKWFIKNDIVCKTLDEQEYLKMLKDLRENILLINNDEIEFSGKQNIWCLKILLVLEDILEEKEALTERSSEQYLVQLIDADPLRKNRYLHLLEQHK"}]}