{"ymdb_id":"YMDB00615","created_at":"2011-05-29T18:36:20.000Z","updated_at":"2016-09-08T18:35:41.000Z","name":"nonaprenyl 4-hydroxybenzoate","cas":null,"state":null,"melting_point":null,"description":"Nonaprenyl 4-hydroxybenzoate is an intermediate in ubiquinol-9 biosynthesis (eukaryotic) pathway. [Biocyc PWY-5871]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"18162","hmdb_id":null,"kegg_id":"C03885","pubchem_id":"5280630","cs_id":"24808132","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-yl 4-hydroxybenzoate","traditional_iupac":"nonaprenyl 4-hydroxybenzoate","logp":"16.312117748","pka":null,"alogps_solubility":"2.29e-04 g/l","alogps_logp":"10.04","alogps_logs":"-6.52","acceptor_count":"2","donor_count":"1","rotatable_bond_count":"28","polar_surface_area":"46.53","refractivity":"249.60320000000004","polarizability":"98.36283971151227","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-6.064637526394638","pka_strongest_acidic":"8.496226040788617","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["3-Nonaprenyl-4-hydroxybenzoate","Nonaprenyl-4-hydroxybenzoate"],"pathways":[{"name":"Ubiquinone and other terpenoid-quinone biosynthesis","kegg_map_id":"00130"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":1763050,"citation":"He, B., Chen, P., Chen, S. Y., Vancura, K. L., Michaelis, S., Powers, S. (1991). \"RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins.\" Proc Natl Acad Sci U S A 88:11373-11377."}],"proteins":[{"created_at":"2011-05-27T04:24:08.000Z","updated_at":"2011-05-29T05:06:41.000Z","name":"Para-hydroxybenzoate--polyprenyltransferase, mitochondrial","uniprot_id":"P32378","uniprot_name":"COQ2_YEAST","enzyme":true,"transporter":false,"gene_name":"COQ2","num_residues":372,"molecular_weight":"41001.0","theoretical_pi":"10.47","general_function":"Involved in prenyltransferase activity","specific_function":"Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB","reactions":[{"id":1645,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2764,"direction":"\u003e","locations":"Mitochondrion inner membrane; Multi-pass membrane protein","altext":"A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"92-112;114-133;170-191;193-210;229-249;298-318","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"AY693097","genbank_protein_id":"51013645","gene_card_id":"COQ2","chromosome_location":"chromosome 14","locus":"YNR041C","synonyms":["PHB:polyprenyltransferase"],"enzyme_classes":["2.5.1.39"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" prenyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"UbiA","identifier":"PF01040"}],"pathways":[],"gene_sequence":"ATGTTTATTTGGCAGAGAAAGAGTATTTTACTAGGGAGGTCCATTCTGGGCAGCGGCCGAGTTACCGTTGCTGGAATCATTGGAAGCAGCAGAAAGAGATATACGTCTTCTTCCTCCTCCTCCTCCTCCCCTTCCTCGAAAGAATCAGCACCTGTGTTTACGTCGAAAGAGTTGGAAGTTGCAAGAAAGGAAAGATTGGATGGACTGGGACCGTTCGTGTCTCGGCTGCCTAAGAAATGGATACCGTATGCGGAGCTGATGAGGCTAGAGAAACCCGTGGGCACGTGGCTGTTATATTTGCCCTGCAGTTGGTCTATACTTATGGGAGCCATGATGCAAGGTGCTACATTGAGCGCAACAGCTGGTATGTTGGGTATTTTCGGTGTAGGTGCATTGGTAATGAGAGGTGCTGGCTGCACCATCAACGATTTTTTGGATAGAAAGTTGGATCAAAGAGTTATCAGGTCCGTCGAGAGGCCTATCGCCTCTGGTAGAGTGAGCCCCCGTCGGGCGTTAGTATTCTTGGGGGCTCAAACTCTTGTTGGAATGGGCGTTCTATCTTTGCTTCCTGCGCAGTGTTGGTGGCTAGGCCTTGCATCGTTACCTATTGTGTTCACATACCCTTTGTTTAAGCGGTTTACGTACTATCCTCAAGCTGCATTAAGTGCATGTTTCAATTGGGGAGCGTTACTTGGGTTTCCTGCCATGGGTGTAATGAGCTGGCCTACAATGATACCTTTGTACCTGAGCAGTTACTTGTGGTGTATGACTTACGATACTATATACGCACACCAGGATAAAAAGTTTGACATCAAGACTGGAATCAAGTCTACCGCTTTGGCTTGGGGTCCACGCACAAAGTCTATCATGAAGGCCATGTCCGCGTCTCAAATCGCACTGTTAGCTGTCGCCGGCTTGAACAGTGGGTTGTTATGGGGGCCTGGGTTCATTGGTGGACTAGGAGTCTTCGCTTATAGACTCTTCAGCATGATAAAGAAAGTGGATCTTGACAATCCTAAAAACTGCTGGAAGTATTTTAATGCAAATATCAACACCGGACTTTACTTTACGTACGCCTTGGCAGTCGACTACATCTTGAGACTGTTTGGATTCTTGTAG","protein_sequence":"MFIWQRKSILLGRSILGSGRVTVAGIIGSSRKRYTSSSSSSSSPSSKESAPVFTSKELEVARKERLDGLGPFVSRLPKKWIPYAELMRLEKPVGTWLLYLPCSWSILMGAMMQGATLSATAGMLGIFGVGALVMRGAGCTINDFLDRKLDQRVIRSVERPIASGRVSPRRALVFLGAQTLVGMGVLSLLPAQCWWLGLASLPIVFTYPLFKRFTYYPQAALSACFNWGALLGFPAMGVMSWPTMIPLYLSSYLWCMTYDTIYAHQDKKFDIKAGIKSTALAWGPRTKSIMKAMSASQIALLAVAGLNSGLLWGPGFIGGLGVFAYRLFSMIKKVDLDNPKNCWKYFNANINTGLYFTYALAVDYILRLFGFL"},{"created_at":"2011-05-27T05:07:16.000Z","updated_at":"2011-05-27T15:01:23.000Z","name":"Protein farnesyltransferase subunit beta","uniprot_id":"P22007","uniprot_name":"FNTB_YEAST","enzyme":true,"transporter":false,"gene_name":"RAM1","num_residues":431,"molecular_weight":"48189.39844","theoretical_pi":"6.35","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins such as a-factor and RAS. The beta subunit is responsible for peptide-binding","reactions":[{"id":2761,"direction":"\u003e","locations":"","altext":"Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M22753","genbank_protein_id":"171420","gene_card_id":"RAM1","chromosome_location":"chromosome 4","locus":"YDL090C","synonyms":["FTase-beta","CAAX farnesyltransferase subunit beta","Ras proteins prenyltransferase subunit beta"],"enzyme_classes":["2.5.1.58"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Prenyltrans","identifier":"PF00432"}],"pathways":[],"gene_sequence":"ATGCGACAGAGAGTAGGAAGGTCCATAGCTAGGGCTAAATTTATAAATACTGCCTTATTAGGAAGAAAGAGACCAGTTATGGAAAGAGTCGTCGATATAGCGCATGTAGATTCAAGTAAAGCAATCCAACCATTGATGAAGGAACTAGAAACCGACACTACAGAAGCACGATACAAAGTACTACAAAGTGTATTAGAGATATACGATGATGAAAAGAATATAGAACCTGCTCTCACGAAAGAGTTTCACAAAATGTACTTGGATGTCGCTTTTGAGATATCGTTACCTCCACAAATGACAGCACTAGATGCTTCACAACCGTGGATGCTATATTGGATTGCTAACTCATTGAAGGTAATGGACAGAGACTGGCTTTCAGATGACACCAAAAGAAAAATTGTAGATAAGCTCTTTACTATTAGTCCTTCAGGAGGACCCTTTGGTGGAGGTCCTGGCCAATTATCTCATTTGGCCAGCACTTATGCTGCAATTAATGCTCTCTCCCTTTGCGATAACATAGATGGATGCTGGGACAGAATTGATCGAAAAGGAATTTACCAATGGCTGATATCGTTGAAAGAGCCTAATGGAGGATTCAAGACCTGTTTAGAAGTCGGAGAAGTGGATACAAGAGGTATATACTGTGCCTTGAGCATAGCAACCTTATTAAATATTCTTACAGAAGAGCTTACAGAAGGTGTGTTAAACTATTTGAAAAATTGTCAAAATTATGAAGGTGGATTCGGCAGTTGTCCTCACGTAGATGAGGCACACGGAGGCTATACTTTCTGTGCTACAGCTAGTCTAGCAATTTTAAGGTCCATGGACCAAATAAATGTTGAAAAGCTTTTAGAATGGTCTAGTGCTCGTCAATTGCAAGAAGAACGAGGATTTTGCGGAAGGAGCAACAAACTTGTTGACGGTTGCTATAGTTTTTGGGTTGGAGGTTCGGCTGCCATTCTTGAAGCTTTTGGATATGGCCAATGCTTCAACAAACATGCTCTTCGGGACTACATATTGTACTGTTGCCAAGAAAAAGAGCAACCTGGTTTGAGAGATAAACCAGGGGCCCACTCAGACTTTTACCATACAAATTATTGCCTATTAGGACTGGCTGTTGCGGAAAGTTCATACAGTTGCACTCCTAATGATTCTCCACATAATATTAAGTGTACTCCAGACCGCCTAATTGGATCATCGAAACTTACTGATGTCAACCCTGTCTATGGTTTACCAATAGAAAATGTAAGAAAAATTATCCACTACTTTAAATCCAATTTATCTTCTCCAAGTTAA","protein_sequence":"MRQRVGRSIARAKFINTALLGRKRPVMERVVDIAHVDSSKAIQPLMKELETDTTEARYKVLQSVLEIYDDEKNIEPALTKEFHKMYLDVAFEISLPPQMTALDASQPWMLYWIANSLKVMDRDWLSDDTKRKIVDKLFTISPSGGPFGGGPGQLSHLASTYAAINALSLCDNIDGCWDRIDRKGIYQWLISLKEPNGGFKTCLEVGEVDTRGIYCALSIATLLNILTEELTEGVLNYLKNCQNYEGGFGSCPHVDEAHGGYTFCATASLAILRSMDQINVEKLLEWSSARQLQEERGFCGRSNKLVDGCYSFWVGGSAAILEAFGYGQCFNKHALRDYILYCCQEKEQPGLRDKPGAHSDFYHTNYCLLGLAVAESSYSCTPNDSPHNIKCTPDRLIGSSKLTDVNPVYGLPIENVRKIIHYFKSNLSSPS"}]}