{"ymdb_id":"YMDB00606","created_at":"2011-05-29T18:35:22.000Z","updated_at":"2016-09-08T18:35:40.000Z","name":"ergosta-5,7,22,24(28)-tetraen-3beta-ol","cas":"","state":null,"melting_point":"","description":"Ergosta-5,7,22,24(28)-tetraen-3beta-ol is involved in steroid biosynthesis. It is converted to egosterol through the removal of a double bond on its carbon chain.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"endoplasmic reticulum;cytoplasm","synthesis_reference":null,"chebi_id":"18249","hmdb_id":null,"kegg_id":"C05440","pubchem_id":"23724485","cs_id":"24850092","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(1S,2R,5S,11R,14R,15R)-2,15-dimethyl-14-[(2R,3E)-6-methyl-5-methylidenehept-3-en-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-7,9-dien-5-ol","traditional_iupac":"5,7,22,24(28)-ergostatetraenol","logp":"6.284761178000001","pka":null,"alogps_solubility":"6.28e-04 g/l","alogps_logp":"7.48","alogps_logs":"-5.80","acceptor_count":"1","donor_count":"1","rotatable_bond_count":"4","polar_surface_area":"20.23","refractivity":"126.90919999999997","polarizability":"50.40834530020503","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-1.3681497086596925","pka_strongest_acidic":"18.270805421445605","bioavailability":"1","number_of_rings":"4","rule_of_five":"0","ghose_filter":"0","veber_rule":"1","mddr_like_rule":"0","synonyms":["(22E)-24-methylcholesta-5,7,22,24(24(1))-tetraen-3beta-ol","5,7,22,24(28)-Ergostatetraenol","Ergosta-5,7,22,24(24(1))-tetraen-3beta-ol","Ergosta-5,7,22,24(241)-tetraen-3beta-ol","Ergosta-5,7,22,24(28)-tetraen-3beta-ol"],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10622712,"citation":"Lamb, D. C., Kelly, D. E., Manning, N. J., Kaderbhai, M. A., Kelly, S. L. (1999). \"Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction.\" FEBS Lett 462:283-288."}],"proteins":[{"created_at":"2011-05-27T01:41:35.000Z","updated_at":"2011-05-27T15:01:15.000Z","name":"NADH-cytochrome b5 reductase 2","uniprot_id":"P36060","uniprot_name":"MCR1_YEAST","enzyme":true,"transporter":false,"gene_name":"MCR1","num_residues":302,"molecular_weight":"34137.69922","theoretical_pi":"9.11","general_function":"Involved in oxidoreductase activity","specific_function":"The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals","reactions":[{"id":2635,"direction":"\u003e","locations":" Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein;Endoplasmic reticulum membrane;NADH-cytochrome b5 reductase p34 form:Mitochondrion outer membrane; Single-pass membrane protein (Potential)","altext":"NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"12-32","pdb_id":null,"cellular_location":"NADH-cytochrome b5 reductase p34 form:Mitochondrion outer membrane; Single-pass membrane protein","genbank_gene_id":"X81474","genbank_protein_id":"1490392","gene_card_id":"MCR1","chromosome_location":"chromosome 11","locus":"YKL150W","synonyms":["Mitochondrial cytochrome b reductase","p34/p32","NADH-cytochrome b5 reductase p34 form","NADH-cytochrome b5 reductase p32 form"],"enzyme_classes":["1.6.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FAD_binding_6","identifier":"PF00970"},{"name":"NAD_binding_1","identifier":"PF00175"}],"pathways":[{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGTTTTCCAGATTATCCAGATCTCACTCAAAAGCATTACCGATTGCTCTAGGTACAGTTGCTATAGCAGCTGCTACCGCATTCTATTTTGCAAACCGTAACCAACATTCCTTTGTCTTCAATGAATCCAATAAAGTATTCAAGGGTGATGACAAATGGATCGACTTGCCAATATCTAAAATAGAGGAGGAATCCCACGACACCAGAAGGTTTACTTTTAAGCTGCCTACTGAAGACTCAGAAATGGGGTTGGTCCTAGCATCTGCTCTGTTTGCTAAATTTGTCACACCAAAGGGATCCAATGTGGTGAGACCATACACTCCTGTGAGTGATCTTTCCCAGAAGGGTCACTTCCAGCTGGTCGTCAAGCATTATGAAGGTGGTAAAATGACCTCACATTTATTTGGTCTTAAACCAAATGACACCGTTTCTTTCAAGGGTCCTATTATGAAATGGAAGTGGCAACCTAATCAGTTCAAGTCAATCACCTTGTTAGGTGCCGGTACCGGTATCAACCCTCTGTACCAATTAGCTCATCATATAGTTGAAAACCCAAACGACAAGACCAAAGTTAACTTGCTATATGGGAACAAGACTCCTCAGGACATTTTACTAAGGAAGGAACTGGATGCGTTGAAGGAAAAGTATCCTGACAAGTTCAATGTTACTTACTTTGTTGACGACAAGCAAGATGACCAAGACTTTGATGGTGAAATTAGTTTCATCTCCAAAGATTTTATTCAGGAGCATGTTCCAGGTCCAAAGGAAAGCACACATTTGTTTGTCTGCGGTCCCCCACCATTTATGAACGCTTACTCAGGTGAGAAGAAGTCACCTAAGGACCAAGGTGAATTGATCGGTATCTTGAACAATTTGGGCTACTCCAAGGACCAAGTTTTCAAATTTTAA","protein_sequence":"MFSRLSRSHSKALPIALGTVAIAAATAFYFANRNQHSFVFNESNKVFKGDDKWIDLPISKIEEESHDTRRFTFKLPTEDSEMGLVLASALFAKFVTPKGSNVVRPYTPVSDLSQKGHFQLVVKHYEGGKMTSHLFGLKPNDTVSFKGPIMKWKWQPNQFKSITLLGAGTGINPLYQLAHHIVENPNDKTKVNLLYGNKTPQDILLRKELDALKEKYPDKFNVTYFVDDKQDDQDFDGEISFISKDFIQEHVPGPKESTHLFVCGPPPFMNAYSGEKKSPKDQGELIGILNNLGYSKDQVFKF"},{"created_at":"2011-05-27T07:22:30.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"NADPH--cytochrome P450 reductase","uniprot_id":"P16603","uniprot_name":"NCPR_YEAST","enzyme":true,"transporter":false,"gene_name":"NCP1","num_residues":691,"molecular_weight":"76771.10156","theoretical_pi":"4.8","general_function":"Involved in oxidoreductase activity","specific_function":"This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5","reactions":[{"id":2811,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass membrane protein","altext":"NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"8-24","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass membrane protein","genbank_gene_id":"AY693091","genbank_protein_id":"51013633","gene_card_id":"NCP1","chromosome_location":"chromosome 8","locus":"YHR042W","synonyms":["CPR","P450R"],"enzyme_classes":["1.6.2.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" FMN binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"NAD_binding_1","identifier":"PF00175"},{"name":"Flavodoxin_1","identifier":"PF00258"},{"name":"FAD_binding_1","identifier":"PF00667"}],"pathways":[],"gene_sequence":"ATGCCGTTTGGAATAGACAACACCGACTTCACTGTCCTGGCGGGGCTAGTGCTTGCCGTGCTACTGTACGTAAAGAGAAACTCCATCAAGGAACTGCTGATGTCCGATGACGGAGATATCACAGCTGTCAGCTCGGGCAACAGGGACATTGCTCAGGTGGTGACCGAAAACAACAAGAACTACTTGGTGTTGTATGCGTCGCAGACTGGGACTGCCGAGGATTACGCCAAAAAGTTTTCCAAGGAGCTGGTGGCCAAGTTCAACCTAAACGTGATGTGCGCAGATGTTGAGAACTACGACTTTGAGTCGCTAAACGATGTGCCCGTCATAGTCTCGATTTTTATCTCTACATATGGTGAAGGAGACTTCCCCGACGGGGCGGTCAACTTTGAAGACTTTATTTGTAATGCGGAAGCGGGTGCACTATCGAACCTGAGGTATAATATGTTTGGTCTGGGAAATTCTACTTATGAATTCTTTAATGGTGCCGCCAAGAAGGCCGAGAAGCATCTCTCCGCCGCGGGCGCTATCAGACTAGGCAAGCTCGGTGAAGCTGATGATGGTGCAGGAACTACAGACGAAGATTACATGGCCTGGAAGGACTCCATCCTGGAGGTTTTGAAAGACGAACTGCATTTGGACGAACAGGAAGCCAAGTTCACCTCTCAATTCCAGTACACTGTGTTGAACGAAATCACTGACTCCATGTCGCTTGGTGAACCCTCTGCTCACTATTTGCCCTCGCATCAGTTGAACCGCAACGCAGACGGCATCCAATTGGGTCCCTTCGATTTGTCTCAACCGTATATTGCACCCATCGTGAAATCTCGCGAACTGTTCTCTTCCAATGACCGTAATTGCATCCACTCTGAATTTGACTTGTCCGGCTCTAACATCAAGTACTCCACTGGTGACCATCTTGCTGTTTGGCCTTCCAACCCATTGGAAAAGGTCGAACAGTTCTTATCCATATTCAACCTGGACCCTGAAACCATTTTTGACTTGAAGCCCCTGGATCCCACCGTCAAAGTGCCCTTCCCAACGCCAACTACTATTGGCGCTGCTATTAAACACTATTTGGAAATTACAGGACCTGTCTCCAGACAATTGTTTTCATCTTTGATTCAGTTCGCCCCCAACGCTGACGTCAAGGAAAAATTGACTCTGCTTTCGAAAGACAAGGACCAATTCGCCGTCGAGATAACCTCCAAATATTTCAACATCGCAGATGCTCTGAAATATTTGTCTGATGGCGCCAAATGGGACACCGTACCCATGCAATTCTTGGTCGAATCAGTTCCCCAAATGACTCCTCGTTACTACTCTATCTCTTCCTCTTCTCTGTCTGAAAAGCAAACCGTCCATGTCACCTCCATTGTGGAAAACTTTCCTAACCCAGAATTGCCTGATGCTCCTCCAGTTGTTGGTGTTACGACTAACTTGTTAAGAAACATTCAATTGGCTCAAAACAATGTTAACATTGCCGAAACTAACCTACCTGTTCACTACGATTTAAATGGCCCACGTAAACTTTTCGCCAATTACAAATTGCCCGTCCACGTTCGTCGTTCTAACTTCAGATTGCCTTCCAACCCTTCCACCCCAGTTATCATGATCGGTCCAGGTACCGGTGTTGCCCCATTCCGTGGGTTTATCAGAGAGCGTGTCGCGTTCCTCGAATCACAAAAGAAGGGCGGTAACAACGTTTCGCTAGGTAAGCATATACTGTTTTATGGATCCCGTAACACTGATGATTTCTTGTACCAGGACGAATGGCCAGAATACGCCAAAAAATTGGATGGTTCGTTCGAAATGGTCGTGGCCCATTCCAGGTTGCCAAACACCAAAAAAGTCTATGTTCAAGATAAATTAAAGGATTACGAAGACCAAGTATTTGAAATGATTAACAACGGTGCATTTATCTACGTCTGTGGTGATGCAAAGGGTATGGCCAAGGGTGTGTCAACCGCATTGGTTGGCATCTTATCCCGTGGTAAATCCATTACCACTGATGAAGCAACAGAGCTAATCAAGATGCTCAAGACTTCAGGTAGATACCAAGAAGATGTCTGGTAA","protein_sequence":"MPFGIDNTDFTVLAGLVLAVLLYVKRNSIKELLMSDDGDITAVSSGNRDIAQVVTENNKNYLVLYASQTGTAEDYAKKFSKELVAKFNLNVMCADVENYDFESLNDVPVIVSIFISTYGEGDFPDGAVNFEDFICNAEAGALSNLRYNMFGLGNSTYEFFNGAAKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKDELHLDEQEAKFTSQFQYTVLNEITDSMSLGEPSAHYLPSHQLNRNADGIQLGPFDLSQPYIAPIVKSRELFSSNDRNCIHSEFDLSGSNIKYSTGDHLAVWPSNPLEKVEQFLSIFNLDPETIFDLKPLDPTVKVPFPTPTTIGAAIKHYLEITGPVSRQLFSSLIQFAPNADVKEKLTLLSKDKDQFAVEITSKYFNIADALKYLSDGAKWDTVPMQFLVESVPQMTPRYYSISSSSLSEKQTVHVTSIVENFPNPELPDAPPVVGVTTNLLRNIQLAQNNVNIAETNLPVHYDLNGPRKLFANYKLPVHVRRSNFRLPSNPSTPVIMIGPGTGVAPFRGFIRERVAFLESQKKGGNNVSLGKHILFYGSRNTDDFLYQDEWPEYAKKLDGSFEMVVAHSRLPNTKKVYVQDKLKDYEDQVFEMINNGAFIYVCGDAKGMAKGVSTALVGILSRGKSITTDEATELIKMLKTSGRYQEDVW"},{"created_at":"2011-05-27T07:25:34.000Z","updated_at":"2011-07-22T17:54:21.000Z","name":"Delta(24(24(1)))-sterol reductase","uniprot_id":"P25340","uniprot_name":"ERG4_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG4","num_residues":473,"molecular_weight":"56039.30078","theoretical_pi":"8.74","general_function":"Involved in delta24(24-1) sterol reductase activity","specific_function":"Ergosterol + NADP(+) = ergosta- 5,7,22,24(24(1))-tetraen-3-beta-ol + NADPH","reactions":[{"id":1362,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2813,"direction":"\u003e","locations":"Membrane; Multi-pass membrane protein","altext":"Ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3-beta-ol + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":14415,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006928","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"40-64;102-123;139-157;175-197;233-249;327-346;415-439","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"S57891","genbank_protein_id":"234325","gene_card_id":"ERG4","chromosome_location":"chromosome 7","locus":"YGL012W","synonyms":["C-24(28) sterol reductase","Sterol Delta(24(28))-reductase"],"enzyme_classes":["1.3.1.71"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ERG4_ERG24","identifier":"PF01222"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null}],"gene_sequence":"ATGGCAAAGGATAATAGTGAGAAGCTGCAGGTGCAGGGAGAGGAGAAAAAGTCCAAGCAACCGGTTAATTTCCTGCCTCAGGGTAAATGGCTGAAGCCAAATGAAATCGAATATGAGTTTGGTGGGACTACTGGTGTTATTGGTATGCTGATCGGGTTTCCACTGCTAATGTACTATATGTGGATTTGTGCGGAATTTTATCACGGTAAGGTTGCCCTACCCAAGGCTGGTGAATCGTGGATGCACTTTATCAAGCACCTATACCAGTTAGTCTTGGAGAACGGTATCCCAGAAAAGTATGACTGGACTATTTTCTTAACATTTTGGGTGTTTCAGATCATTTTCTACTATACGTTGCCCGGGATTTGGACAAAAGGTCAACCATTGTCTCATTTGAAGGGAAAACAATTGCCTTACTTTTGTAATGCCATGTGGACCTTGTATGTAACTACCACTTTGGTCTTGGTTTTGCACTTTACCAATCTTTTTAGATTGTATGTCATTATTGACCGTTTTGGGAGGATCATGACATGTGCCATTATTTCAGGGTTTGCCTTCTCCATCATATTGTACTTATGGACTTTATTTATCTCACATGACTATCATAGAATGACAGGAAACCATCTATATGATTTCTTCATGGGAGCTCCACTAAACCCTAGGTGGGGGATTTTGGACTTGAAGATGTTTTTCGAGGTTAGATTACCTTGGTTCACCCTTTACTTTATCACTTTGGGTGCCTGTTTGAAGCAGTGGGAGACTTACGGCTATGTGACACCACAATTGGGGGTTGTCATGTTAGCTCATTGGTTGTACGCGAACGCATGTGCTAAAGGTGAAGAATTGATTGTTCCAACCTGGGACATGGCTTACGAAAAGTTTGGATTTATGCTGATCTTCTGGAATATTGCCGGTGTCCCATACACTTACTGTCATTGTACGTTGTATTTGTACTACCATGACCCATCTGAATATCACTGGTCTACACTGTACAATGTTTCGCTGTACGTTGTTCTATTATGCGCCTACTACTTCTTTGACACGGCAAATGCTCAGAAAAATGCCTTCAGAAAGCAAATGTCTGGTGACAAGACAGTTAGGAAGACTTTCCCATTTTTGCCATACCAAATTTTGAAGAATCCAAAGTATATGGTTACCTCCAATGGATCGTACCTATTGATTGATGGTTGGTACACTTTGGCTAGAAAAATTCACTACACTGCCGATTGGACTCAATCTCTCGTTTGGGCCTTGTCTTGCGGGTTCAACTCGGTGTTCCCATGGTTTTTCCCAGTATTCTTCCTTGTTGTCCTGATTCACAGAGCCTTCAGAGACCAAGCAAAATGTAAGAGAAAGTACGGAAAAGATTGGGATGAGTATTGTAAACATTGCCCTTACGTCTTTATTCCTTATGTTTTCTAG","protein_sequence":"MAKDNSEKLQVQGEEKKSKQPVNFLPQGKWLKPNEIEYEFGGTTGVIGMLIGFPLLMYYMWICAEFYHGKVALPKAGESWMHFIKHLYQLVLENGIPEKYDWTIFLTFWVFQIIFYYTLPGIWTKGQPLSHLKGKQLPYFCNAMWTLYVTTTLVLVLHFTNLFRLYVIIDRFGRIMTCAIISGFAFSIILYLWTLFISHDYHRMTGNHLYDFFMGAPLNPRWGILDLKMFFEVRLPWFTLYFITLGACLKQWETYGYVTPQLGVVMLAHWLYANACAKGEELIVPTWDMAYEKFGFMLIFWNIAGVPYTYCHCTLYLYYHDPSEYHWSTLYNVSLYVVLLCAYYFFDTANAQKNAFRKQMSGDKTGRKTFPFLPYQILKNPKYMVTSNGSYLLIDGWYTLARKIHYTADWTQSLVWALSCGFNSVFPWFFPVFFLVVLIHRAFRDQAKCKRKYGKDWDEYCKHCPYVFIPYVF"},{"created_at":"2011-05-29T04:39:32.000Z","updated_at":"2011-05-29T04:39:32.000Z","name":"NADH-cytochrome b5 reductase 1","uniprot_id":"P38626","uniprot_name":"NCB5R_YEAST","enzyme":true,"transporter":false,"gene_name":"CBR1","num_residues":284,"molecular_weight":"31493.59961","theoretical_pi":"9.19","general_function":"Involved in oxidoreductase activity","specific_function":"Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes. Plays a role in bud morphology","reactions":[{"id":2635,"direction":"\u003e","locations":" Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein;Endoplasmic reticulum membrane;NADH-cytochrome b5 reductase p34 form:Mitochondrion outer membrane; Single-pass membrane protein (Potential)","altext":"NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"7-27","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein (Potential)","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"CBR1","chromosome_location":null,"locus":null,"synonyms":["Microsomal cytochrome b reductase","P35"],"enzyme_classes":["1.6.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FAD_binding_6","identifier":"PF00970"},{"name":"NAD_binding_1","identifier":"PF00175"}],"pathways":[{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGGCTATTGATGCTCAAAAGCTTGTGGTGGTCATCGTGATCGTGGTCGTGCCTTTGCTCTTCAAGTTCATTATCGGACCGAAGACCAAGCCTGTGCTGGATCCCAAAAGGAATGACTTCCAATCATTTCCGCTGGTTGAAAAAACCATCTTAACGCATAATACTTCGATGTACAAGTTCGGGCTACCTCATGCTGACGACGTACTCGGTTTACCAATTGGTCAGCATATCGTAATTAAGGCCAATATCAATGGTAAGGATATTACCAGATCGTATACGCCCACATCGTTGGATGGAGATACAAAGGGAAACTTTGAATTACTAGTGAAGTCTTACCCCACAGGTAACGTTTCTAAGATGATTGGAGAGTTGAAGATAGGTGACTCGATCCAGATCAAGGGCCCTCGTGGGAACTATCATTATGAGAGAAACTGCCGTTCCCATCTAGGGATGATTGCTGGTGGTACTGGTATTGCGCCCATGTATCAGATCATGAAAGCTATTGCCATGGACCCTCACGACACTACCAAGGTCTCTCTAGTCTTTGGGAACGTCCATGAGGAGGATATTCTGTTGAAGAAGGAACTGGAAGCGTTGGTGGCCATGAAGCCTTCCCAATTTAAGATAGTTTACTACTTAGACTCTCCTGACCGTGAAGACTGGACTGGTGGTGTAGGATACATTACCAAGGATGTCATCAAGGAACACTTGCCCGCTGCTACAATGGACAACGTTCAAATTTTGATCTGTGGTCCTCCAGCCATGGTTGCCTCAGTTAGAAGAAGTACCGTGGACTTGGGGTTCAGACGTTCCAAACCGCTTTCCAAGATGGAAGACCAGGTGTTTGTGTTTTAA","protein_sequence":"MAIDAQKLVVVIVIVVVPLLFKFIIGPKTKPVLDPKRNDFQSFPLVEKTILTHNTSMYKFGLPHADDVLGLPIGQHIVIKANINGKDITRSYTPTSLDGDTKGNFELLVKSYPTGNVSKMIGELKIGDSIQIKGPRGNYHYERNCRSHLGMIAGGTGIAPMYQIMKAIAMDPHDTTKVSLVFGNVHEEDILLKKELEALVAMKPSQFKIVYYLDSPDREDWTGGVGYITKDVIKEHLPAATMDNVQILICGPPAMVASVRRSTVDLGFRRSKPLSKMEDQVFVF"},{"created_at":"2011-07-22T06:23:02.000Z","updated_at":"2011-07-22T06:23:02.000Z","name":"Cytochrome P450 61","uniprot_id":"P54781","uniprot_name":"ERG5_YEAST","enzyme":false,"transporter":false,"gene_name":"ERG5","num_residues":538,"molecular_weight":"61333.80078","theoretical_pi":"8.01","general_function":"Secondary metabolites biosynthesis, transport and catabolism","specific_function":"Required to form the C-22(23) double bond in the sterol side chain","reactions":[{"id":14414,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006927","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U34636","genbank_protein_id":"1235991","gene_card_id":"ERG5","chromosome_location":null,"locus":null,"synonyms":["C-22 sterol desaturase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"metal ion binding"},{"category":"Function","description":"transition metal ion binding"},{"category":"Function","description":"catalytic activity"},{"category":"Function","description":"oxidoreductase activity"},{"category":"Function","description":"heme binding"},{"category":"Function","description":"electron carrier activity"},{"category":"Function","description":"iron ion binding"},{"category":"Function","description":"monooxygenase activity"},{"category":"Function","description":"binding"},{"category":"Function","description":"ion binding"},{"category":"Function","description":"cation binding"}],"pfams":[{"name":"p450","identifier":"PF00067"}],"pathways":[{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null},{"name":"Steroid biosynthesis","kegg_map_id":"00100"}],"gene_sequence":"ATGAGTTCTGTCGCAGAAAATATAATACAACATGCCACTCATAATTCTACGCTACACCAATTGGCTAAAGACCAGCCCTCTGTAGGCGTCACTACTGCCTTCAGTATCCTGGATACACTTAAGTCTATGTCATATTTGAAAATATTTGCTACTTTAATCTGTATTCTTTTGGTTTGGGACCAAGTTGCATATCAAATCAAGAAAGGTTCCATCGCAGGTCCAAAGTTTAAGTTCTGGCCCATCATCGGTCCATTTTTGGAATCCTTAGATCCAAAGTTTGAAGAATATAAGGCTAAGTGGGCATCCGGTCCACTTTCATGTGTTTCTATTTTCCATAAATTTGTTGTTATCGCATCTACTAGAGACTTGGCAAGAAAGATCTTGCAATCTTCCAAATTCGTCAAACCTTGCGTTGTCGATGTTGCTGTGAAGATCTTAAGACCTTGCAATTGGGTTTTTTTGGACGGTAAAGCTCATACTGATTACAGAAAATCATTAAACGGTCTTTTCACTAAACAAGCTTTGGCTCAATACTTACCTTCATTGGAACAAATCATGGATAAGTACATGGATAAGTTTGTTCGTTTATCTAAGGAGAATAACTACGAGCCCCAGGTCTTTTTCCATGAAATGAGAGAAATTCTTTGCGCCTTATCATTGAACTCTTTCTGTGGTAACTATATTACCGAAGATCAAGTCAGAAAGATTGCTGATGATTACTATTTGGTTACAGCAGCATTGGAATTAGTCAACTTCCCAATTATTATCCCTTACACTAAAACATGGTATGGTAAGAAAACTGCAGACATGGCCATGAAGATTTTCGAAAACTGTGCTCAAATGGCTAAGGATCATATTGCTGCAGGTGGTAAGCCAGTTTGTGTTATGGATGCTTGGTGTAAGTTGATGCACGATGCAAAGAATAGTAACGATGATGATTCTAGAATCTACCACAGAGAGTTTACTAACAAGGAAATCTCCGAAGCTGTTTTCACTTTCTTATTTGCTTCTCAAGATGCCTCTTCTTCTTTAGCTTGTTGGTTGTTCCAAATTGTTGCTGACCGTCCAGATGTCTTAGCTAAGATCAGAGAAGAACAATTGGCTGTTCGTAACAATGACATGTCTACCGAATTGAACTTGGATTTGATTGAGAAAATGAAGTACACCAATATGGTCATAAAAGAAACTTTGCGTTACAGACCTCCTGTCTTGATGGTTCCATATGTTGTTAAGAAGAATTTCCCAGTTTCCCCTAACTATACCGCACCAAAGGGCGCTATGTTAATTCCAACCTTATACCCAGCTTTACATGATCCTGAAGTTTACGAAAATCCTGATGAGTTCATCCCTGAAAGATGGGTAGAAGGCTCTAAGGCTAGTGAAGCAAAGAAGAATTGGTTGGTTTTTGGTTGTGGTCCACACGTTTGCTTAGGTCAAACATATGTCATGATTACCTTCGCCGCTTTGTTGGGTAAATTTGCACTATATACTGATTTCCATCATACAGTGACTCCATTAAGTGAAAAAATCAAGGTTTTCGCTACAATTTTCCCAAAAGATGATTTGTTACTGACTTTCAAAAAGAGAGACCCAATTACTGGAGAAGTCTTCGAATAA","protein_sequence":"MSSVAENIIQHATHNSTLHQLAKDQPSVGVTTAFSILDTLKSMSYLKIFATLICILLVWDQVAYQIKKGSIAGPKFKFWPIIGPFLESLDPKFEEYKAKWASGPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHTDYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCALSLNSFCGNYITEDQVRKIADDYYLVTAALELVNFPIIIPYTKTWYGKKTADMAMKIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDDSRIYHREFTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYRPPVLMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIPERWVEGSKASEAKKNWLVFGCGPHVCLGQTYVMITFAALLGKFALYTDFHHTVTPLSEKIKVFATIFPKDDLLLTFKKRDPITGEVFE"}]}