{"ymdb_id":"YMDB00565","created_at":"2011-05-29T18:31:41.000Z","updated_at":"2016-09-08T18:35:37.000Z","name":"2',3'-cyclic AMP","cas":"634-01-5","state":"Solid","melting_point":null,"description":"2',3'-cyclic AMP is involved in purine metabolism[KEGG]. This metabolite should not be confused with its positional isomer, the common secound messenger, cAMP (3',5'-cyclic AMP). ","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"27844","hmdb_id":"HMDB11616","kegg_id":"C02353","pubchem_id":"6992262","cs_id":"91988","foodb_id":null,"wikipedia_link":null,"biocyc_id":"2-HYDROXYDEOXYADENOSINE-5-TRIPHOSPHATE","iupac":"(3aR,4R,6R,6aR)-4-(6-amino-9H-purin-9-yl)-2-hydroxy-6-(hydroxymethyl)-tetrahydro-2H-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-2-one","traditional_iupac":"2',3'-cyclic amp","logp":"-3.8298289107849044","pka":"14.584307323434835","alogps_solubility":"3.59e+00 g/l","alogps_logp":"-2.51","alogps_logs":"-1.96","acceptor_count":"8","donor_count":"3","rotatable_bond_count":"2","polar_surface_area":"154.84","refractivity":"70.28949999999999","polarizability":"28.282347602081263","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"4.9887015214332004","pka_strongest_acidic":"1.7592537911346091","bioavailability":"1","number_of_rings":"4","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(3aR,4R,6R,6aR)-4-(6-amino-9H-purin-9-yl)-6-(hydroxymethyl)tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-2-ol 2-oxide","2',3'-cAMP","2',3'-Cyclic adenosine monophosphate","2',3'-Cyclic AMP","Adenosine 2',3'-cyclic phosphate","adenosine cyclic 2',3'-(hydrogen phosphate)","Adenosine cyclic 2',3'-monophosphate","cyclic 2',3'-(hydrogen phosphate)-Adenosine","Cyclic 2',3'-AMP"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10734185,"citation":"Nasr, F., Filipowicz, W. (2000). \"Characterization of the Saccharomyces cerevisiae cyclic nucleotide phosphodiesterase involved in the metabolism of ADP-ribose 1\",2\"-cyclic phosphate.\" Nucleic Acids Res 28:1676-1683."}],"proteins":[{"created_at":"2011-05-27T07:43:59.000Z","updated_at":"2011-07-22T17:54:01.000Z","name":"2',3'-cyclic-nucleotide 3'-phosphodiesterase","uniprot_id":"P53314","uniprot_name":"CPD1_YEAST","enzyme":true,"transporter":false,"gene_name":"CPD1","num_residues":239,"molecular_weight":"26731.40039","theoretical_pi":"7.53","general_function":"Involved in cyclic-nucleotide phosphodiesterase activity","specific_function":"Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing","reactions":[{"id":1283,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2815,"direction":"\u003e","locations":"Golgi apparatus","altext":"Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 2'-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Golgi apparatus","genbank_gene_id":"AY558381","genbank_protein_id":"45270652","gene_card_id":"CPD1","chromosome_location":"chromosome 7","locus":"YGR247W","synonyms":["CPDase"],"enzyme_classes":["3.1.4.37"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphoric diester hydrolase activity"},{"category":"Function","description":" cyclic-nucleotide phosphodiesterase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"CPDase","identifier":"PF07823"}],"pathways":[],"gene_sequence":"ATGGCAATAGCATTATGGTATTGTCCACCACAAGGATCAGTTGCTTACGAGACATTACAGATGCTTATATTTTCGTTTCAAACGTTGTTCCCAGATTCACCAGTTTTTGAACCTCATGTGACGGTAACGTCCCATTTGGTGTGCAATAGTAAAGATGATGTCAACAAAATCTTGACCTCCTGTGTTGCTGCCATCCAATCGATAAGGTCACACCAAACAGCAAAGAAAGGACGTAAGGGACAGGTATCCCATGCTGTTGCAGCTCCTTTGGTATCTTTCAATGGATGCAGTGTAGGTAAACAATATTTCAAGAAAATTGTGCTCGAGTGTAACAAGAACAAAATACTTTATGGGGTCGCACAAGTCATGAGAGAGATGTACGTAGAGATCGATCCTGAGACGCGAAGTAGCCGTGCCGCCACTTGGGTGCACGAGGAATTCCATCCTCACGTCTCATTGCTTTATTCGGATATTCATCCGGTAAGTCAGGCGTCATTGCGAGTAGTTCAACAAAGAATTGAAGATGCTCTAGACGTGCAACTAGTTCCAAGAGAGAAACGTAAGGGTTCCGGAAACGCTGATGGGTCCAATGAAGTGCAAATGAGATGGGATTTTGACGTATCTTCATCGCTATCTTGGAATATCCCAGGAACGTTTAAAGTGGTCAACTGTGTGGGGCCCGTTCAAGAATGGGAGGTATTGGGACGGGTGGACGTTTAA","protein_sequence":"MAIALWYCPPQGSVAYETLQMLIFSFQTLFPDSPVFEPHVTVTSHLVCNSKDDVNKILTSCVAAIQSIRSHQTAKKGRKGQVSHAVAAPLVSFNGCSVGKQYFKKIVLECNKNKILYGVAQVMREMYVEIDPETRSSRAATWVHEEFHPHVSLLYSDIHPVSQASLRVVQQRIEDALDVQLVPREKRKGSGNADGSNEVQMRWDFDVSSSLSWNIPGTFKVVNCVGPVQEWEVLGRVDV"}]}