{"ymdb_id":"YMDB00558","created_at":"2011-05-29T18:30:55.000Z","updated_at":"2016-09-08T18:35:37.000Z","name":"GTP","cas":"86-01-1","state":"Solid","melting_point":null,"description":"Guanosine triphosphate (GTP) is a guanine nucleotide containing three phosphate groups esterified to the sugar moiety. GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cytoplasm;Mitochondrion","synthesis_reference":"Stiller, Regine; Thiem, Joachim.  Preparative enzymatic conversion of guanosine-5'-monophosphate to guanosine-5'-triphosphate.    Synlett  (1990),   (11),  709-10.","chebi_id":"15996","hmdb_id":"HMDB01273","kegg_id":"C00044","pubchem_id":"6830","cs_id":"6569","foodb_id":null,"wikipedia_link":"Guanosine_triphosphate","biocyc_id":"GTP","iupac":"({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid","traditional_iupac":"triphosphate, guanosine","logp":"-3.673381185333333","pka":"2.531489582454818","alogps_solubility":"1.04e+01 g/l","alogps_logp":"-0.63","alogps_logs":"-1.70","acceptor_count":"14","donor_count":"8","rotatable_bond_count":"8","polar_surface_area":"294.80999999999995","refractivity":"97.23979999999996","polarizability":"39.807618203983395","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":"-1.8565367830540338","pka_strongest_acidic":"0.8960309756959344","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["5'-GTP","GTG","GTP","Guanosine 5'-(tetrahydrogen triphosphate)","Guanosine 5'-triphosphate","Guanosine 5'-triphosphorate","Guanosine 5'-triphosphoric acid","Guanosine Triphosphate"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Riboflavin metabolism","kegg_map_id":"00740"},{"name":"Folate biosynthesis","kegg_map_id":"00790"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":14998997,"citation":"Vozza, A., Blanco, E., Palmieri, L., Palmieri, F. (2004). \"Identification of the mitochondrial GTP/GDP transporter in Saccharomyces cerevisiae.\" J Biol Chem 279:20850-20857."},{"pubmed_id":10409709,"citation":"Gao, X. D., Kaigorodov, V., Jigami, Y. (1999). \"YND1, a homologue of GDA1, encodes membrane-bound apyrase required for Golgi N- and O-glycosylation in Saccharomyces cerevisiae.\" J Biol Chem 274:21450-21456."}],"proteins":[{"created_at":"2011-05-24T19:49:46.000Z","updated_at":"2011-07-22T17:54:14.000Z","name":"Protein APA1","uniprot_id":"P16550","uniprot_name":"APA1_YEAST","enzyme":true,"transporter":false,"gene_name":"APA1","num_residues":321,"molecular_weight":"36492.19922","theoretical_pi":"4.66","general_function":"Involved in ATP adenylyltransferase activity","specific_function":"Ap4A phosphorylase catabolizes Ap4N nucleotides (where N is A,C,G or U). Additionally this enzyme catalyzes the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulfate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP","reactions":[{"id":1339,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1340,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1991,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2273,"direction":"\u003e","locations":"","altext":"ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2274,"direction":"\u003e","locations":null,"altext":"ADP + sulfate = phosphate + adenylyl sulfate.","export":false,"pw_reaction_id":null,"source":null},{"id":2275,"direction":"\u003e","locations":null,"altext":"Adenylylsulfate + ATP = P(1),P(4)-bis(5'-adenosyl)tetraphosphate + sulfate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M31791","genbank_protein_id":"171064","gene_card_id":"APA1","chromosome_location":"chromosome 3","locus":"YCL050C","synonyms":["5',5'''-P-1,P-4-tetraphosphate phosphorylase","ATP adenylyltransferase","Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase","AP,A phosphorylase","AP-4-A phosphorylase","ADP-sulfurylase"],"enzyme_classes":["2.7.7.53","2.7.7.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Function","description":" adenylyltransferase activity"},{"category":"Function","description":" ATP adenylyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ATP_transf","identifier":"PF09830"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGAGTATCCCCGCTGACATTGCATCTTTAATTAGTGACAAGTACAAAAGTGCCTTCGATAATGGTAACTTAAAATTTATCCAGACTGAAACAACGAAAACAAAGGACCCAAAAACCAGCATGCCATACTTGATTAGTCACATGCCAAGTCTGATCGAAAAGCCAGAGCGTGGCCAAACTCCAGAAGGAGAGGATCCACTAGGCAAACCTGAGGAAGAATTAACGGTTATCCCAGAATTTGGTGGTGCCGATAACAAAGCGTATAAATTGCTATTAAACAAATTCCCTGTAATCCCTGAACACACTTTATTGGTAACTAACGAATACCAACATCAAACTGATGCCTTGACCCCAACCGATTTATTGACTGCTTATAAGTTGCTGTGTGCCTTGGACAATGAAGAATCCGACAAGAGACACATGGTCTTTTACAATTCTGGTCCAGCCAGTGGTTCTTCATTGGACCACAAACATTTGCAAATTCTGCAAATGCCTGAAAAGTTCGTCACTTTCCAAGATAGACTATGTAATGGTAAAGAACATTTCCTACCAACTTTCAATACTGAACCTTTGCAAGATGCTAAAGTCTCGTTCGCTCATTTTGTCTTGCCAATGCCGGAGTCTGAAGAAACTGTTGATGAAGACCTATTAGCTATGTGTTACATCTCCATATTGCAAAGAGCTTTGACCTTTTTCCAGGACTGGTTGAACGAAAATCCAGAACTAAAGAAATCCTACAATCTTATGTTAACCAAGGAATGGATCTGTGTCGTTCCACGCTCGAAGGCCTTTTCTGATGAAATGAAGATAGGTTTCAACTCCACAGGTTATTGTGGTATGATCTTAACCAAAAATGATGAAGTTTTCTCCAAGATTACTGAAAAACCTGAATTGATTAACGATATCTTATTGGAATGTGGTTTCCCAAACACTTCTGGTCAAAAACCAAACGAATACAACTATTGA","protein_sequence":"MSIPADIASLISDKYKSAFDNGNLKFIQTETTKTKDPKTSMPYLISHMPSLIEKPERGQTPEGEDPLGKPEEELTVIPEFGGADNKAYKLLLNKFPVIPEHTLLVTNEYQHQTDALTPTDLLTAYKLLCALDNEESDKRHMVFYNSGPASGSSLDHKHLQILQMPEKFVTFQDRLCNGKEHFLPTFNTEPLQDAKVSFAHFVLPMPESEETVDEDLLAMCYISILQRALTFFQDWLNENPELKKSYNLMLTKEWICVVPRSKAFSDEMKIGFNSTGYCGMILTKNDEVFSKITEKPELINDILLECGFPNTSGQKPNEYNY"},{"created_at":"2011-05-24T19:58:22.000Z","updated_at":"2011-07-22T17:54:01.000Z","name":"Adenylosuccinate synthetase","uniprot_id":"P80210","uniprot_name":"PURA_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE12","num_residues":433,"molecular_weight":"48279.10156","theoretical_pi":"8.37","general_function":"Involved in adenylosuccinate synthase activity","specific_function":"Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP","reactions":[{"id":1280,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2285,"direction":"\u003e","locations":"Cytoplasm","altext":"GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"L22185","genbank_protein_id":"347863","gene_card_id":"ADE12","chromosome_location":"chromosome 14","locus":"YNL220W","synonyms":["AMPSase","AS-synthetase","AdSS","IMP--aspartate ligase"],"enzyme_classes":["6.3.4.4"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" purine nucleotide binding"},{"category":"Function","description":" guanyl nucleotide binding"},{"category":"Function","description":" guanyl ribonucleotide binding"},{"category":"Function","description":" GTP binding"},{"category":"Function","description":" adenylosuccinate synthase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"}],"pfams":[{"name":"Adenylsucc_synt","identifier":"PF00709"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGGTTAACGTTGTATTGGGCTCCCAATGGGGTGATGAGGGTAAAGGTAAACTAGTTGATTTACTGGTTGGTAAATATGATATTGTAGCCCGTTGCGCCGGTGGTAACAATGCCGGGCATACCATTGTTGTAGACGGTGTTAAGTATGATTTCCATATGTTACCATCTGGTTTAGTCAACCCAAACTGCCAAAACCTTTTGGGTAATGGTGTTGTTATTCATGTTCCATCTTTTTTCAAAGAGTTGGAAACCTTGGAAGCTAAAGGTTTGAAGAACGCAAGGAGTAGATTATTTGTTTCTTCCAGAGCACATTTAGTCTTTGACTTTCATCAGGTGACTGACAAGCTAAGAGAATTGGAGTTATCAGGTCGTTCTAAAGATGGTAAAAATATCGGTACTACCGGTAAAGGTATTGGTCCAACTTATTCCACAAAGGCTTCTAGATCTGGTTTGAGAGTTCATCATTTGGTGAATGATCAACCCGGTGCCTGGGAGGAATTTGTTGCTAGATATAAGAGATTATTGGAAACGAGAAGACAAAGATACGGTGATTTCGAATACGACTTTGAAGCCAAGCTTGCTGAATACAAGAAGTTAAGAGAGCAACTAAAGCCATTCGTCGTCGATTCTGTCGTTTTCATGCACAATGCTATTGAAGCAAAGAAAAAGATATTGGTTGAGGGTGCTAATGCTTTGATGTTGGATATTGATTTTGGTACTTATCCATATGTGACTTCTTCCAATACTGGTATTGGTGGTGTCCTCACCGGTTTAGGTATTCCTCCACGTACTATTGATGAAATTTATGGTGTTGTTAAAGCCTACACAACTAGAGTTGGTGAAGGTCCTTTCCCAACGGAACAATTGAACGAAAATGGAGAAAAACTGCAGACCATTGGTGCTGAATTTGGTGTCACTACTGGTCGTAAGCGTCGTTGCGGTTGGTTAGACTTGGTAGTCTTGAAATACTCAACTTTGATCAATGGATACACGAGTTTGAACATTACCAAGTTAGACGTCCTCGATACTTTCAAAGAAATCCCAGTGGGTATTTCATATTCTATTCAAGGTAAGAAGCTAGATTTGTTCCCTGAAGACTTGAATATTCTTGGTAAAGTTGAAGTTGAATACAAAGTTTTGCCAGGTTGGGATCAAGATATTACCAAAATTACAAAGTATGAAGATTTGCCGGAAAACGCAAAGAAGTACTTAAAATATATTGAAGATTTTGTTGGCGTTCCTGTTGAATGGGTTGGTACCGGCCCCGCAAGAGAAAGCATGTTGCATAAAGAAATTAAATAG","protein_sequence":"MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELETLEAKGLKNARSRLFVSSRAHLVFDFHQVTDKLRELELSGRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQPGAWEEFVARYKRLLETRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPENAKKYLKYIEDFVGVPVEWVGTGPARESMLHKEIK"},{"created_at":"2011-05-24T21:16:20.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial","uniprot_id":"P53598","uniprot_name":"SUCA_YEAST","enzyme":true,"transporter":false,"gene_name":"LSC1","num_residues":329,"molecular_weight":"35032.19922","theoretical_pi":"8.76","general_function":"Involved in catalytic activity","specific_function":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA","reactions":[{"id":2376,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":3700,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003283","source":"Smpdb"},{"id":3701,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006825","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"X94335","genbank_protein_id":"1164984","gene_card_id":"LSC1","chromosome_location":"chromosome 15","locus":"YOR142W","synonyms":["Succinyl-CoA synthetase subunit alpha","SCS-alpha"],"enzyme_classes":["6.2.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer"},{"category":"Function","description":" ligase activity, forming carbon-sulfur bonds"},{"category":"Function","description":" CoA-ligase activity"},{"category":"Function","description":" succinate-CoA ligase activity"},{"category":"Function","description":" succinate-CoA ligase (ADP-forming) activity"},{"category":"Function","description":" ATP citrate synthase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"CoA_binding","identifier":"PF02629"},{"name":"Ligase_CoA","identifier":"PF00549"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTAAGATCTACCGTTTCAAAAGCTTCTCTCAAAATTTGTCGTCACTTTCACAGAGAATCTATTCCTTACGATAAGACGATCAAAAATTTGCTGCTTCCCAAGGACACCAAGGTGATCTTTCAGGGGTTCACAGGTAAACAAGGTACTTTTCATGCCAGCATCTCTCAAGAATATGGTACAAATGTTGTGGGTGGTACGAACCCAAAAAAGGCGGGTCAAACACATTTAGGCCAACCTGTCTTTGCCTCTGTGAAGGACGCGATTAAGGAGACTGGAGCCACTGCCAGTGCCATCTTTGTTCCTCCACCGATCGCAGCTGCTGCCATTAAAGAATCTATTGAAGCTGAAATTCCGTTAGCTGTATGTATCACTGAAGGTATTCCTCAACATGACATGTTATACATTGCAGAAATGTTGCAGACACAAGATAAAACAAGATTAGTTGGGCCCAACTGCCCTGGTATCATTAACCCAGCAACAAAGGTAAGAATTGGTATCCAGCCCCCAAAAATTTTTCAAGCTGGTAAAATCGGTATTATTTCCAGATCGGGAACTTTGACATACGAAGCTGTTCAGCAAACTACAAAAACTGACCTTGGTCAATCACTGGTTATTGGTATGGGTGGTGATGCTTTTCCCGGTACTGATTTTATTGACGCCTTGAAATTATTTCTAGAAGATGAAACTACAGAAGGTATTATTATGTTAGGTGAAATAGGTGGTAAGGCCGAAATCGAAGCTGCTCAATTTCTCAAAGAATACAACTTTAGCAGGAGTAAGCCGATGCCGGTGGCATCTTTCATCGCAGGAACTGTTGCTGGTCAAATGAAAGGTGTTAGAATGGGTCACTCCGGTGCAATTGTAGAAGGATCTGGAACTGATGCAGAATCCAAAAAACAAGCTTTGAGAGATGTTGGTGTTGCCGTCGTTGAATCTCCAGGTTACTTAGGTCAAGCTTTACTGGATCAATTTGCCAAATTTAAATGA","protein_sequence":"MLRSTVSKASLKICRHFHRESIPYDKTIKNLLLPKDTKVIFQGFTGKQGTFHASISQEYGTNVVGGTNPKKAGQTHLGQPVFASVKDAIKETGATASAIFVPPPIAAAAIKESIEAEIPLAVCITEGIPQHDMLYIAEMLQTQDKTRLVGPNCPGIINPATKVRIGIQPPKIFQAGKIGIISRSGTLTYEAVQQTTKTDLGQSLVIGMGGDAFPGTDFIDALKLFLEDETTEGIIMLGEIGGKAEIEAAQFLKEYNFSRSKPMPVASFIAGTVAGQMKGVRMGHSGAIVEGSGTDAESKKQALRDVGVAVVESPGYLGQALLDQFAKFK"},{"created_at":"2011-05-26T16:17:09.000Z","updated_at":"2011-05-27T15:00:59.000Z","name":"Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial","uniprot_id":"P53312","uniprot_name":"SUCB_YEAST","enzyme":true,"transporter":false,"gene_name":"LSC2","num_residues":427,"molecular_weight":"46900.30078","theoretical_pi":"7.56","general_function":"Involved in catalytic activity","specific_function":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA","reactions":[{"id":2376,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":3700,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003283","source":"Smpdb"},{"id":3701,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006825","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"Z73029","genbank_protein_id":"1323442","gene_card_id":"LSC2","chromosome_location":"chromosome 7","locus":"YGR244C","synonyms":["Succinyl-CoA synthetase beta chain","SCS-beta"],"enzyme_classes":["6.2.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Ligase_CoA","identifier":"PF00549"},{"name":"ATP-grasp_2","identifier":"PF08442"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTACTCAAGAAAATCCTTATCCCTAATTTCAAAGTGTGGGCAATTAAGCAGGCTAAACGCGCAAGCTGCTTTACAAGCAAGGAGACACTTGTCAATTCATGAATACAGGTCAGCTCAGTTATTGAGGGAATACGGTATTGGTACTCCAGAAGGATTTCCAGCGTTCACTCCCGAAGAGGCTTTCGAAGCAGCCAAGAAATTAAACACTAACAAACTGGTCATCAAGGCGCAGGCATTGACCGGAGGTAGAGGTAAAGGTCACTTCGACACCGGTTACAAAAGCGGTGTTCACATGATCGAAAGTCCTCAGCAGGCAGAGGATGTTGCAAAAGAAATGCTCAATCATAACCTGATTACTAAACAGACGGGAATAGCGGGGAAGCCAGTATCTGCTGTATATATAGTGAAAAGAGTAGATACAAAGCATGAAGCTTATTTATCTATTCTAATGGACAGACAAACCAAGAAACCGATGATCATTGCGTCCAGTCAAGGTGGTATGAATATTGAAGAGGTGGCTGAGAGAACCCCAGATGCTATAAAGAAATTTTCAATTGAAACTTCAAAGGGATTGAGCCCACAAATGGCCAAGGATGTTGCCAAGAGTCTCGGTTTCAGTCCCGATGCACAAGACGAGGCAGCAAAAGCTGTTTCCAATTTGTATAAAATATTCATGGAAAGGGATGCTACACAAGTGGAGATTAACCCTTTGAGTGAAATTGAACATGATCCAACCCACAAAATCATGTGTACAGACGCCAAATTTGGGTTTGATGATAACGCATCATTCAGACAGGAAAAGATATATTCCTGGAGGGACTTATCACAAGAAGATCCTGATGAAGTTAAGGCAAAGAAGTATGATTTGAATTTTGTTAAGTTGAAGGGTAACATTGGATGTTTAGTCAATGGTGCTGGTTTGGCTATGGCTACTATGGATGTCATCAAATTAAATGGAGGCGATCCTGCGAACTTTTTGGATTGTGGTGGTGGTGCCACCCCTGAGACCATCAAACAAGGTTTCGAATTGATCTTATCCAATAAGAACGTAGATGCAATTTTCGTCAATATTTTCGGCGGTATCGTAAGATGTGACTATGTTGCCCTGGGGCTGGTAGAAGCCGCCAGAGAACTAGAAGTTAGGGTCCCCATTGTGGCACGTTTGCAAGGTACCAAAGTAGAAGAAGGCCGCGACATTATCAATAAGTCAGGCGTGAAGATTTATTCGTTTGATGAATTAGATCCTGCTGCTAAAAAGGTCGTTGAATTGACCCAAAATTAA","protein_sequence":"MYSRKSLSLISKCGQLSRLNAQAALQARRHLSIHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGHFDTGYKSGVHMIESPQQAEDVAKEMLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKGLSPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEIEHDPTHKIMCTDAKFGFDDNASFRQEKIYSWRDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKNVDAIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVELTQN"},{"created_at":"2011-05-26T16:38:22.000Z","updated_at":"2011-07-22T17:54:14.000Z","name":"Golgi apyrase","uniprot_id":"P40009","uniprot_name":"YND1_YEAST","enzyme":true,"transporter":false,"gene_name":"YND1","num_residues":630,"molecular_weight":"71851.20313","theoretical_pi":"6.18","general_function":"Involved in hydrolase activity","specific_function":"Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis","reactions":[{"id":1341,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1618,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1782,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1784,"direction":"\u003e","locations":"Golgi;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1785,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2043,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2435,"direction":"\u003e","locations":"Golgi apparatus. Membrane; Single-pass membrane protein (Potential)","altext":"ATP + 2 H(2)O = AMP + 2 phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"501-517","pdb_id":null,"cellular_location":"Golgi apparatus. 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The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Required for repair of UV radiation- and etoposide-induced DNA damage","reactions":[{"id":1786,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1787,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1788,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1789,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1790,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1791,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1792,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1793,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1794,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2454,"direction":"\u003e","locations":"Cytoplasm. 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(R)-5-phosphomevalonate.","export":false,"pw_reaction_id":null,"source":null},{"id":14369,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006887","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X06114","genbank_protein_id":"4287","gene_card_id":"ERG12","chromosome_location":"chromosome 13","locus":"YMR208W","synonyms":["MK","MvK","Ergosterol biosynthesis protein 12","Regulation of autonomous replication protein 1"],"enzyme_classes":["2.7.1.36"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphotransferase activity, 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cellular lipid metabolic process"},{"category":"Process","description":" isoprenoid metabolic process"},{"category":"Process","description":" isoprenoid biosynthetic process"},{"category":"Process","description":" primary metabolic process"}],"pfams":[{"name":"GHMP_kinases_N","identifier":"PF00288"}],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism 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kinase 2","uniprot_id":"P26364","uniprot_name":"KAD2_YEAST","enzyme":true,"transporter":false,"gene_name":"ADK2","num_residues":225,"molecular_weight":"25193.69922","theoretical_pi":"9.42","general_function":"Involved in ATP binding","specific_function":"This small ubiquitous enzyme is essential for maintenance and cell growth","reactions":[{"id":1276,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1277,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1278,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2551,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm, cytosol. Mitochondrion intermembrane space;Mitochondrion","altext":"ATP + AMP = 2 ADP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY558457","genbank_protein_id":"45270804","gene_card_id":"ADK2","chromosome_location":"chromosome 5","locus":"YER170W","synonyms":["AK 2","ATP-AMP transphosphorylase 2"],"enzyme_classes":["2.7.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" nucleotide kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide kinase activity"},{"category":"Function","description":" adenylate kinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}],"pfams":[{"name":"ADK","identifier":"PF00406"},{"name":"ADK_lid","identifier":"PF05191"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGAAAGCAGACGCGAAACAAATAACACATCTACTCAAACCTCTTCGACTTTTATTATTGGGGGCTCCAGGGTCAGGTAAAGGGACACAGACTTCGAGATTACTAAAGCAAATTCCACAATTATCTTCAATTTCGTCAGGCGACATTTTACGTCAGGAAATAAAATCTGAATCTACCCTAGGCCGAGAGGCTACTACCTACATTGCTCAAGGCAAGTTATTACCGGATGATCTCATAACGCGTCTGATAACTTTTCGTCTTTCGGCATTGGGTTGGTTAAAACCATCTGCCATGTGGTTGCTCGATGGATTTCCTCGAACTACTGCGCAAGCTTCTGCCTTAGACGAGCTGCTGAAACAGCATGACGCCAGCTTGAATCTAGTGGTAGAGCTAGATGTACCCGAATCCACCATATTAGAAAGGATCGAGAACAGATATGTTCACGTTCCTAGTGGGAGAGTGTATAACTTACAATATAATCCTCCCAAAGTGCCAGGATTAGACGATATCACCGGAGAACCATTGACCAAGAGGCTTGATGACACAGCGGAAGTGTTTAAAAAAAGGCTAGAAGAGTACAAGAAAACAAATGAGCCTTTAAAAGATTATTACAAAAAAAGTGGGATTTTTGGTACCGTCTCTGGGGAAACATCAGATATTATCTTCCGAAATTATTGA","protein_sequence":"MKADAKQITHLLKPLRLLLLGAPGSGKGTQTSRLLKQIPQLSSISSGDILRQEIKSESTLGREATTYIAQGKLLPDDLITRLITFRLSALGWLKPSAMWLLDGFPRTTAQASALDELLKQHDASLNLVVELDVPESTILERIENRYVHVPSGRVYNLQYNPPKVPGLDDITGEPLTKRLDDTAEVFKKRLEEYKKTNEPLKDYYKKSGIFGTVSGETSDIIFRNY"},{"created_at":"2011-05-26T18:59:10.000Z","updated_at":"2011-07-22T17:54:00.000Z","name":"Adenylate kinase 1","uniprot_id":"P07170","uniprot_name":"KAD1_YEAST","enzyme":true,"transporter":false,"gene_name":"ADK1","num_residues":222,"molecular_weight":"24254.5","theoretical_pi":"6.37","general_function":"Involved in ATP binding","specific_function":"Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in the cytoplasm and mitochondrion intermembrane space","reactions":[{"id":1276,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1277,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1278,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2551,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm, cytosol. Mitochondrion intermembrane space;Mitochondrion","altext":"ATP + AMP = 2 ADP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1AKY","cellular_location":"Cytoplasm, cytosol. Mitochondrion intermembrane space","genbank_gene_id":"AY558578","genbank_protein_id":"45271046","gene_card_id":"ADK1","chromosome_location":"chromosome 4","locus":"YDR226W","synonyms":["AK 1","ATP-AMP transphosphorylase 1","Adenylate kinase cytosolic and mitochondrial"],"enzyme_classes":["2.7.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" nucleotide kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide kinase activity"},{"category":"Function","description":" adenylate kinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}],"pfams":[{"name":"ADK","identifier":"PF00406"},{"name":"ADK_lid","identifier":"PF05191"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGTCTAGCTCAGAATCCATTAGAATGGTCCTAATTGGCCCACCTGGTGCCGGTAAAGGTACTCAAGCTCCAAATTTGCAAGAGCGTTTCCATGCCGCTCACTTGGCCACTGGTGACATGTTGAGATCTCAAATCGCAAAGGGCACTCAATTAGGTTTGGAAGCAAAGAAAATTATGGACCAAGGTGGTTTAGTCTCTGATGACATTATGGTTAACATGATCAAGGATGAATTGACCAACAATCCAGCTTGTAAGAATGGGTTCATCTTGGACGGTTTCCCAAAAACCATTCCTCAGGCTGAAAAATTGGACCAAATGTTGAAAGAACAAGGAACTCCTTTGGAAAAAGCCATCGAATTGAAGGTTGATGATGAATTGTTGGTTGCCAGAATTACCGGTAGATTAATTCACCCAGCCTCTGGCAGATCCTACCACAAGATCTTTAACCCACCAAAGGAAGACATGAAGGATGACGTCACCGGTGAAGCTTTAGTTCAAAGATCTGATGACAATGCAGACGCCTTGAAGAAGAGATTAGCTGCTTACCATGCTCAAACCGAACCAATTGTTGACTTTTACAAAAAGACCGGTATCTGGGCTGGTGTTGATGCTTCCCAACCTCCTGCTACTGTTTGGGCTGACATCTTGAACAAGCTAGGTAAGGATTAA","protein_sequence":"MSSSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGKD"},{"created_at":"2011-05-26T21:50:14.000Z","updated_at":"2011-07-22T17:54:14.000Z","name":"5',5'''-P-1,P-4-tetraphosphate phosphorylase 2","uniprot_id":"P22108","uniprot_name":"APA2_YEAST","enzyme":true,"transporter":false,"gene_name":"APA2","num_residues":325,"molecular_weight":"36840.5","theoretical_pi":"5.23","general_function":"Involved in ATP adenylyltransferase activity","specific_function":"Sustains the catabolism of Np-4-N' nucleotides, rather than their synthesis","reactions":[{"id":1338,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2273,"direction":"\u003e","locations":"","altext":"ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M60265","genbank_protein_id":"171066","gene_card_id":"APA2","chromosome_location":"chromosome 4","locus":"YDR530C","synonyms":["ATP adenylyltransferase","Ap4A phosphorylase II","AP,A phosphorylase","Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase","AP-4-A phosphorylase"],"enzyme_classes":["2.7.7.53"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Function","description":" adenylyltransferase activity"},{"category":"Function","description":" ATP adenylyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ATP_transf","identifier":"PF09830"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGATTGAAGAGAATTTGAAACAGAAAATCCACGATAAGTTCGTTGCAGCCAAAAAGAATGGGCATCTGAAAGTAACGCATGCAGAATCCAAGAAGTTGAAAGATCCTCAAACGACGACACAATATTGGGTGACATTTGCTCCATCTTTGGCACTTAAGCCAGACGCTAACAAGAATAGCGATTCAAAGGCGGAGGACCCGTTCGCCAATCCCGACGAAGAACTAGTGGTGACTGAAGATCTAAATGGTGACGGAGAATATAAGCTGCTACTCAACAAATTTCCTGTGGTCCCTGAACATAGTCTCCTAGTGACAAGCGAGTTTAAAGACCAGAGATCTGCTTTGACGCCAAGTGACTTGATGACTGCTTATAATGTGCTCTGTTCTCTCCAAGGAGACAAGGACGATGATGTCACTTGTGAAAGGTATCTGGTCTTTTATAATTGTGGACCTCATAGCGGTTCCTCACAAGATCACAAACACTTGCAGATCATGCAAATGCCTGAAAAATTTATACCTTTTCAGGACGTATTGTGCAACGGAAAGGATCATTTCTTGCCCACCTTCAACGCAGAGCCATTACAAGATGATAAGGTTTCCTTTGCTCATTTCGTCTTGCCGCTGCCGGAATCGTCTGATCAAGTGGACGAAGATCTTCTTGCTATGTGTTACGTATCTTTGATGCAGAGAGCACTTACATTTTTCCAAGATTGGACCAATGAGTCTCCGGAGTTGACCAAGTCATACAATGTGCTACTGACCAAGAAATGGATCTGTGTAGTTCCAAGATCGCATGCCAAGAGTGGACCGCCATTGATGTTAAACATTAACTCCACGGGGTACTGTGGTATGATCCTCGTTAAAGACAGAGAAAAACTAGAGAACCTCACTGAAGATCCTCATCTTGTGGACAAGTCGTTACTGCAATGCGGTTTCCCCAACACAGCAGGCCAAAAACCAACAGAGTATCACTATTAA","protein_sequence":"MIEENLKQKIHDKFVAAKKNGHLKVTHAESKKLKDPQTTTQYWVTFAPSLALKPDANKNSDSKAEDPFANPDEELVVTEDLNGDGEYKLLLNKFPVVPEHSLLVTSEFKDQRSALTPSDLMTAYNVLCSLQGDKDDDVTCERYLVFYNCGPHSGSSQDHKHLQIMQMPEKFIPFQDVLCNGKDHFLPTFNAEPLQDDKVSFAHFVLPLPESSDQVDEDLLAMCYVSLMQRALTFFQDWTNESPELTKSYNVLLTKKWICVVPRSHAKSGPPLMLNINSTGYCGMILVKDREKLENLTEDPHLVDKSLLQCGFPNTAGQKPTEYHY"},{"created_at":"2011-05-27T02:42:30.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"GTP cyclohydrolase-2","uniprot_id":"P38066","uniprot_name":"RIB1_YEAST","enzyme":true,"transporter":false,"gene_name":"RIB1","num_residues":345,"molecular_weight":"38331.60156","theoretical_pi":"6.29","general_function":"Involved in GTP cyclohydrolase II activity","specific_function":"Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate","reactions":[{"id":1617,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2688,"direction":"\u003e","locations":"Cytoplasmic","altext":"GTP + 3 H(2)O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14108,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006539","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"X74738","genbank_protein_id":"511141","gene_card_id":"RIB1","chromosome_location":"chromosome 2","locus":"YBL033C","synonyms":["GTP cyclohydrolase II"],"enzyme_classes":["3.5.4.25"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" cyclohydrolase activity"},{"category":"Function","description":" GTP cyclohydrolase activity"},{"category":"Function","description":" GTP cyclohydrolase II activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" riboflavin metabolic process"},{"category":"Process","description":" riboflavin biosynthetic process"}],"pfams":[{"name":"GTP_cyclohydro2","identifier":"PF00925"}],"pathways":[{"name":"Riboflavin metabolism","kegg_map_id":"00740"}],"gene_sequence":"ATGACCATAGATAACTACGACAACAGTAAACAGGATAGCAGCAAATACGAGGTTAGTGGTACGGGTGATGGCAGGAACGGCGATGGCGGCTTGCCTCTAGTACAATGTGTCGCAAGAGCTCGTATCCCAACCACACAGGGTCCGGATATCTTTTTACATCTTTACAGTAACAACAGGGACAACAAGGAACATCTAGCCATTGTGTTTGGTGAAGACATACGGTCGCGCTCGCTATTCCGTAGAAGACAGTGCGAGACGCAACAAGATAGAATGATCAGGGGCGCTTATATTGGCAAACTGTATCCCGGCAGAACTGTGGCAGACGAAGACGATAGACTCGGATTAGCTCTGGAGTTTGATGATAGTACAGGTGAGTTATTAGCTTCCAAAGCCACTACATGGGACGCCCATAACGACACGCTGGTACGGATCCATTCTGAATGTTACACCGGTGAAAACGCATGGAGCGCCCGTTGTGATTGTGGTGAACAATTCGATAGGGCCGGTAGGCTTATCGCTTGCGACCACGAACCCACAAGCAAGATCAAAGGTGGAAACGGCCATGGTGTTATCGTGTATCTAAGACAAGAGGGTCGTGGCATCGGGTTAGGTGAGAAACTCAAGGCCTACAACCTGCAAGACTTAGGTGCTGACACAGTGCAGGCCAACTTAATGCTGAAACATCCCGTGGATGCTAGGGACTTCTCGCTGGGTAAGGCTATTTTGCTGGATCTTGGCATCGGTAATGTCAGGCTGCTGACAAATAACCCGGAAAAGATAAAACAGGTAGATCATGCGCCTTACCTTAAGTGCGTTGAACGAGTGCCTATGGTACCCATACACTGGACAAACTCCAGTGAAGGCATAGACTCCAAGGAGATAGAAGGTTATCTCAGGACCAAGATAGAAAGAATGGGTCATTTACTAACGGAGCCTCTGAAACTTCATACAAACCCTCAACCTACTGAGACAAGTGAAGCCCAAAACCAAAACCGTATGAACTCTGCGTTGTCATCAACATCGACGCTGGCAATATAA","protein_sequence":"MTIDNYDNSKQDSSKYEVSGTGDGRNGDGGLPLVQCVARARIPTTQGPDIFLHLYSNNRDNKEHLAIVFGEDIRSRSLFRRRQCETQQDRMIRGAYIGKLYPGRTVADEDDRLGLALEFDDSTGELLASKATTWDAHNDTLVRIHSECYTGENAWSARCDCGEQFDRAGRLIACDHEPTSNIKGGNGHGVIVYLRQEGRGIGLGEKLKAYNLQDLGADTVQANLMLKHPVDARDFSLGKAILLDLGIGNVRLLTNNPEKIKQVDHAPYLKCVERVPMVPIHWTNSSEGIDSKEIEGYLRTKIERMGHLLTEPLKLHTNPQPTETSEAQNQNRMNSALSSTSTLAI"},{"created_at":"2011-05-27T03:51:12.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Thioredoxin-2","uniprot_id":"P22803","uniprot_name":"TRX2_YEAST","enzyme":true,"transporter":false,"gene_name":"TRX2","num_residues":104,"molecular_weight":"11203.7998","theoretical_pi":"4.54","general_function":"Involved in electron carrier activity","specific_function":"Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism. Through its capacity to inactivate the stress response transcription factor YAP1 and its regulator the hydroperoxide stress sensor HYR1, it is involved in feedback regulation of stress response gene expression upon oxidative stress","reactions":[{"id":1949,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1950,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1951,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1952,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus","genbank_gene_id":"AY557817","genbank_protein_id":"45269525","gene_card_id":"TRX2","chromosome_location":"chromosome 7","locus":"YGR209C","synonyms":["Thioredoxin II","TR-II","Thioredoxin-1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" protein disulfide oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"},{"category":"Process","description":" organic ether metabolic process"},{"category":"Process","description":" glycerol ether metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Thioredoxin","identifier":"PF00085"}],"pathways":[],"gene_sequence":"ATGGTCACTCAATTAAAATCCGCTTCTGAATACGACAGTGCTTTAGCATCTGGCGACAAGTTAGTCGTTGTTGACTTTTTTGCCACATGGTGTGGGCCATGTAAAATGATTGCACCAATGATTGAAAAGTTTGCAGAACAATATTCTGACGCTGCTTTTTACAAGTTGGATGTTGATGAAGTCTCAGATGTTGCTCAAAAAGCTGAAGTTTCTTCCATGCCTACCCTAATCTTCTACAAGGGCGGTAAGGAGGTTACCAGAGTCGTCGGTGCCAACCCAGCTGCTATCAAGCAAGCTATTGCTTCCAACGTATAG","protein_sequence":"MVTQLKSASEYDSALASGDKLVVVDFFATWCGPCKMIAPMIEKFAEQYSDAAFYKLDVDEVSDVAQKAEVSSMPTLIFYKGGKEVTRVVGANPAAIKQAIASNV"},{"created_at":"2011-05-27T03:51:46.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Thioredoxin-1","uniprot_id":"P22217","uniprot_name":"TRX1_YEAST","enzyme":true,"transporter":false,"gene_name":"TRX1","num_residues":103,"molecular_weight":"11234.90039","theoretical_pi":"4.54","general_function":"Involved in electron carrier activity","specific_function":"Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism","reactions":[{"id":1949,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1950,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1951,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1952,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus","genbank_gene_id":"AY558203","genbank_protein_id":"45270296","gene_card_id":"TRX1","chromosome_location":"chromosome 12","locus":"YLR043C","synonyms":["Thioredoxin I","TR-I","Thioredoxin-2"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" protein disulfide oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"},{"category":"Process","description":" organic ether metabolic process"},{"category":"Process","description":" glycerol ether metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Thioredoxin","identifier":"PF00085"}],"pathways":[],"gene_sequence":"ATGGTTACTCAATTCAAAACTGCCAGCGAATTCGACTCTGCAATTGCTCAAGACAAGCTAGTTGTCGTAGATTTCTACGCCACTTGGTGCGGTCCATGTAAAATGATTGCTCCAATGATTGAAAAATTCTCTGAACAATACCCACAAGCTGATTTCTATAAATTGGATGTCGATGAATTGGGTGATGTTGCACAAAAGAATGAAGTTTCCGCTATGCCAACTTTGCTTCTATTCAAGAACGGTAAGGAAGTTGCAAAGGTTGTTGGTGCCAACCCAGCGGCTATTAAGCAAGCCATTGCTGCTAATGCTTAA","protein_sequence":"MVTQFKTASEFDSAIAQDKLVVVDFYATWCGPCKMIAPMIEKFSEQYPQADFYKLDVDELGDVAQKNEVSAMPTLLLFKNGKEVAKVVGANPAAIKQAIAANA"},{"created_at":"2011-05-27T03:55:36.000Z","updated_at":"2011-05-27T03:55:36.000Z","name":"Mannose-1-phosphate guanyltransferase","uniprot_id":"P41940","uniprot_name":"MPG1_YEAST","enzyme":true,"transporter":false,"gene_name":"MPG1","num_residues":361,"molecular_weight":"39565.60156","theoretical_pi":"6.27","general_function":"Involved in transferase activity","specific_function":"Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell- size checkpoint","reactions":[{"id":1725,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2748,"direction":"\u003e","locations":"Cytoplasm","altext":"GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.","export":false,"pw_reaction_id":null,"source":null},{"id":4138,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006434","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U19608","genbank_protein_id":"1292898","gene_card_id":"MPG1","chromosome_location":null,"locus":"YDL055C","synonyms":["ATP-mannose-1-phosphate guanylyltransferase","GDP-mannose pyrophosphorylase","NDP-hexose pyrophosphorylase"],"enzyme_classes":["2.7.7.13"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Hexapep","identifier":"PF00132"},{"name":"NTP_transferase","identifier":"PF00483"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGAAAGGTTTAATTTTAGTCGGTGGTTACGGTACCAGATTGAGACCTTTAACTTTGACCGTTCCAAAGCCACTGGTTGAATTCGGTAATAGACCAATGATTTTACACCAAATCGAGGCTTTAGCCAACGCTGGTGTTACTGACATCGTTCTTGCTGTTAATTACAGACCAGAAGTCATGGTGGAAACTTTGAAGAAGTACGAAAAGGAATATGGTGTTAACATCACTTTCTCTGTAGAAACTGAACCATTAGGTACTGCAGGTCCATTGAAATTGGCTGAAGATGTTTTGAAGAAGGACAACTCTCCATTTTTCGTCCTAAACTCCGACGTCATTTGCGAATATCCATTCAAGGAATTGGCTGACTTCCACAAAGCTCACGGTGGTAAAGGTACCATTGTTGCTACCAAGGTCGACGAACCTTCTAAATACGGTGTCATTGTCCATGATATAGCTACTCCAAACTTGATTGACAGATTTGTTGAAAAGCCAAAGGAATTTGTTGGTAACAGAATTAACGCCGGTTTGTACATTTTAAACCCAGAAGTCATTGACTTGATTGAAATGAAGCCAACTTCAATTGAAAAGGAAACTTTCCCAATCTTGGTCGAAGAAAAACAACTATATTCCTTCGATTTGGAAGGTTTCTGGATGGATGTTGGTCAACCAAAGGACTTCTTGTCTGGTACCGTTCTTTACTTGAACTCTTTGGCCAAGAGACAACCAAAAAAATTGGCTACAGGTGCCAACATTGTTGGTAATGCCTTGATCGACCCAACCGCTAAGATTTCCTCCACTGCTAAGATTGGCCCAGACGTGGTTATCGGTCCTAATGTCACCATCGGTGATGGTGTTAGAATCACCAGATCTGTTGTTTTGTGCAACTCCACCATCAAGAACCACTCCTTGGTCAAATCTACCATCGTAGGCTGGAACTCTACCGTTGGTCAATGGTGTCGTTTGGAAGGTGTCACTGTCTTGGGTGACGACGTTGAAGTTAAGGACGAAATCTACATCAACGGTGGTAAAGTCTTACCTCATAAGTCTATCTCCGATAATGTTCCAAAGGAAGCTATTATTATGTGA","protein_sequence":"MKGLILVGGYGTRLRPLTLTVPKPLVEFGNRPMILHQIEALANAGVTDIVLAVNYRPEVMVETLKKYEKEYGVNITFSVETEPLGTAGPLKLAEDVLKKDNSPFFVLNSDVICEYPFKELADFHKAHGGKGTIVATKVDEPSKYGVIVHDIATPNLIDRFVEKPKEFVGNRINAGLYILNPEVIDLIEMKPTSIEKETFPILVEEKQLYSFDLEGFWMDVGQPKDFLSGTVLYLNSLAKRQPKKLATGANIVGNALIDPTAKISSTAKIGPDVVIGPNVTIGDGVRITRSVVLCNSTIKNHSLVKSTIVGWNSTVGQWCRLEGVTVLGDDVEVKDEIYINGGKVLPHKSISDNVPKEAIIM"},{"created_at":"2011-05-27T05:39:13.000Z","updated_at":"2011-06-05T02:48:57.000Z","name":"Putative mitochondrial carrier protein YHM1/SHM1","uniprot_id":"P38988","uniprot_name":"YHM1_YEAST","enzyme":false,"transporter":true,"gene_name":"YHM1","num_residues":300,"molecular_weight":"33215.19922","theoretical_pi":"10.66","general_function":"Involved in guanine nucleotide transmembrane transporte","specific_function":null,"reactions":[],"signal_regions":"None","transmembrane_regions":"14-34;85-101;122-142;173-189;214-234;268-285","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"AY693086","genbank_protein_id":"51013623","gene_card_id":"YHM1","chromosome_location":null,"locus":"YDL198C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" binding"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGCCTCATACCGATAAGAAACAATCAGGATTAGCTCGTCTTTTGGGGTCCGCCTCTGCAGGCATAATGGAAATTGCCGTCTTCCATCCTGTGGACACCATTTCCAAAAGACTGATGTCCAACCACACCAAAATAACCTCTGGCCAGGAATTGAATCGTGTTATTTTTCGTGATCATTTCAGCGAACCTTTGGGCAAACGTTTGTTTACCTTGTTCCCGGGTCTCGGTTACGCTGCATCATACAAAGTTCTTCAAAGAGTGTATAAATATGGTGGTCAGCCTTTTGCTAACGAGTTTTTGAATAAGCACTACAAAAAGGATTTTGATAATCTTTTCGGTGAAAAGACTGGTAAGGCAATGAGATCCGCCGCTGCTGGATCTTTGATTGGTATTGGTGAAATTGTTCTTTTGCCGCTGGACGTGTTGAAGATTAAGAGACAGACCAATCCCGAATCGTTTAAAGGTAGAGGTTTCATCAAGATTTTGAGAGACGAAGGCCTGTTCAACTTATATAGGGGTTGGGGGTGGACGGCTGCCAGAAATGCTCCCGGTTCATTCGCCCTTTTTGGTGGTAATGCATTCGCCAAGGAGTATATCTTGGGTTTGAAAGATTATTCTCAAGCTACTTGGTCCCAAAACTTCATCTCCTCCATCGTCGGTGCTTGCTCCTCTCTGATCGTTTCTGCTCCATTAGATGTCATCAAGACAAGAATTCAAAATAGGAATTTTGATAATCCTGAAAGCGGGTTGAGAATCGTCAAAAACACTCTGAAAAATGAAGGTGTAACTGCGTTTTTCAAGGGCTTAACACCTAAATTACTAACAACGGGTCCAAAACTGGTTTTCTCATTTGCGTTAGCTCAATCTTTGATACCTAGATTCGATAACCTGTTGAGCAAATGA","protein_sequence":"MPHTDKKQSGLARLLGSASAGIMEIAVFHPVDTISKRLMSNHTKITSGQELNRVIFRDHFSEPLGKRLFTLFPGLGYAASYKVLQRVYKYGGQPFANEFLNKHYKKDFDNLFGEKTGKAMRSAAAGSLIGIGEIVLLPLDVLKIKRQTNPESFKGRGFIKILRDEGLFNLYRGWGWTAARNAPGSFALFGGNAFAKEYILGLKDYSQATWSQNFISSIVGACSSLIVSAPLDVIKTRIQNRNFDNPESGLRIVKNTLKNEGVTAFFKGLTPKLLTTGPKLVFSFALAQSLIPRFDNLLSK"},{"created_at":"2011-05-27T07:12:32.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"GTP cyclohydrolase 1","uniprot_id":"P51601","uniprot_name":"GCH1_YEAST","enzyme":true,"transporter":false,"gene_name":"FOL2","num_residues":243,"molecular_weight":"27768.80078","theoretical_pi":"7.25","general_function":"Involved in GTP cyclohydrolase I activity","specific_function":"GTP + H(2)O = formate + 2-amino-4-hydroxy-6- (erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate","reactions":[{"id":1616,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2802,"direction":"\u003e","locations":"Cytoplasmic","altext":"GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4140,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006439","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"AY692993","genbank_protein_id":"51013437","gene_card_id":"FOL2","chromosome_location":"chromosome 7","locus":"YGR267C","synonyms":["GTP cyclohydrolase I","GTP-CH-I"],"enzyme_classes":["3.5.4.16"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" GTP cyclohydrolase activity"},{"category":"Function","description":" GTP cyclohydrolase I activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" cyclohydrolase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" tetrahydrofolate biosynthetic process"}],"pfams":[{"name":"GTP_cyclohydroI","identifier":"PF01227"}],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGCATAACATCCAATTAGTGCAAGAGATAGAAAGACATGAAACCCCGTTAAACATTAGACCTACCTCTCCATACACTTTAAACCCTCCTGTCGAGAGAGATGGGTTTTCTTGGCCAAGTGTGGGTACAAGACAACGTGCAGAGGAAACTGAAGAGGAGGAAAAGGAACGAATTCAACGCATTTCAGGCGCTATCAAGACAATTTTGACCGAACTGGGTGAAGATGTCAACAGAGAAGGTCTACTAGATACTCCACAAAGATACGCTAAAGCCATGCTTTATTTCACTAAAGGTTACCAAACGAACATTATGGACGATGTCATTAAGAATGCTGTCTTTGAAGAAGATCATGATGAAATGGTTATTGTTCGTGATATTGAAATTTACTCGTTATGTGAACATCATTTGGTGCCATTTTTCGGCAAGGTTCATATCGGGTATATACCAAATAAAAAAGTCATCGGGTTAAGTAAGTTGGCCAGATTGGCAGAAATGTATGCGAGAAGGCTCCAAGTTCAAGAAAGACTTACAAAGCAAATTGCAATGGCCCTAAGTGATATTCTAAAACCATTAGGTGTAGCCGTTGTTATGGAAGCTTCTCATATGTGCATGGTTTCAAGAGGCATTCAAAAAACGGGATCTTCTACGGTAACTTCTTGTATGCTTGGAGGGTTTAGGGCTCATAAAACAAGAGAAGAGTTTTTAACTCTTTTAGGAAGAAGAAGTATTTGA","protein_sequence":"MHNIQLVQEIERHETPLNIRPTSPYTLNPPVERDGFSWPSVGTRQRAEETEEEEKERIQRISGAIKTILTELGEDVNREGLLDTPQRYAKAMLYFTKGYQTNIMDDVIKNAVFEEDHDEMVIVRDIEIYSLCEHHLVPFFGKVHIGYIPNKKVIGLSKLARLAEMYARRLQVQERLTKQIAMALSDILKPLGVAVVMEASHMCMVSRGIQKTGSSTVTSCMLGGFRAHKTREEFLTLLGRRSI"},{"created_at":"2011-06-14T19:36:11.000Z","updated_at":"2011-06-14T19:36:11.000Z","name":"Dynamin-related protein DNM1","uniprot_id":"P54861","uniprot_name":"DNM1_YEAST","enzyme":true,"transporter":false,"gene_name":"DNM1","num_residues":757,"molecular_weight":"84971.0","theoretical_pi":"5.16","general_function":"Involved in GTP binding","specific_function":"Microtubule-associated force-producing protein that participates mitochondrial fission. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Functions antagonistically with FZO1","reactions":[{"id":2857,"direction":"\u003e","locations":"Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.","altext":"GTP + H(2)O = GDP + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.","genbank_gene_id":"X91488","genbank_protein_id":"1495224","gene_card_id":"DNM1","chromosome_location":"chromosome 12","locus":"YLL001W","synonyms":[],"enzyme_classes":["3.6.5.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" GTPase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" purine nucleotide binding"},{"category":"Function","description":" guanyl nucleotide binding"},{"category":"Function","description":" guanyl ribonucleotide binding"},{"category":"Function","description":" GTP binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" nucleoside-triphosphatase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Dynamin_M","identifier":"PF01031"},{"name":"Dynamin_N","identifier":"PF00350"},{"name":"GED","identifier":"PF02212"}],"pathways":[],"gene_sequence":"ATGGCTAGTTTAGAAGATCTTATTCCTACTGTCAACAAGCTGCAGGATGTTATGTACGACTCCGGGATCGATACACTCGATTTGCCCATTTTAGCTGTTGTTGGGTCACAATCCTCCGGGAAATCCTCGATATTGGAAACGTTAGTTGGAAGAGATTTTTTACCTAGGGGTACTGGTATTGTCACAAGAAGACCGTTAGTTCTTCAACTTAATAACATATCTCCAAATTCTCCTCTAATAGAGGAAGATGATAACTCAGTTAATCCACATGATGAAGTTACAAAAATATCAGGATTCGAAGCTGGTACGAAGCCCTTGGAGTATAGGGGCAAGGAAAGAAATCATGCAGATGAGTGGGGGGAATTCCTGCATATACCAGGAAAACGGTTTTATGATTTCGACGATATCAAAAGAGAAATCGAAAACGAAACAGCGAGGATAGCCGGTAAGGATAAGGGCATCAGTAAGATTCCGATTAATTTGAAAGTGTTTTCCCCTCATGTTTTGAATCTAACGCTAGTAGATTTGCCTGGGATTACAAAGGTTCCTATTGGGGAACAACCACCTGATATTGAAAAGCAAATCAAGAATTTGATCCTAGACTATATAGCCACTCCAAATTGTTTAATCTTGGCCGTCTCTCCAGCTAACGTTGATCTTGTTAATTCTGAATCCTTAAAGTTGGCCAGAGAGGTAGACCCTCAGGGCAAAAGGACTATTGGTGTCATTACCAAATTAGATTTGATGGATTCTGGGACTAATGCTCTAGATATCTTGTCTGGAAAAATGTATCCTCTGAAATTGGGGTTTGTTGGTGTAGTGAATCGCTCGCAACAGGATATTCAATTGAACAAAACCGTTGAAGAATCATTGGACAAAGAAGAGGACTATTTCAGGAAACATCCAGTCTACAGAACTATTTCAACAAAGTGTGGTACGCGTTATTTAGCTAAATTGCTAAACCAGACATTATTAAGCCACATTAGAGACAAGCTTCCGGATATTAAAACCAAGTTAAATACCCTGATCTCTCAAACCGAACAAGAGCTCGCTAGATACGGTGGCGTAGGAGCTACTACTAATGAAAGCAGAGCTAGCCTTGTTCTTCAACTAATGAATAAGTTTTCTACAAACTTCATTTCATCTATAGATGGTACATCCTCCGACATTAATACGAAGGAACTCTGTGGTGGTGCCCGTATTTATTACATTTACAATAATGTTTTTGGGAATTCTTTGAAGTCGATTGATCCAACTTCTAATTTATCCGTTCTTGATGTTAGAACAGCGATTAGAAATTCTACTGGTCCCCGTCCTACATTATTTGTACCTGAGTTGGCTTTTGACCTATTGGTTAAACCTCAAATTAAACTTTTACTAGAACCATCTCAACGTTGCGTCGAGTTAGTTTACGAGGAGCTGATGAAAATATGCCATAAATGTGGCTCCGCTGAGCTAGCTAGATATCCTAAATTGAAGAGTATGTTAATAGAAGTTATAAGCGAACTACTTAGAGAAAGGTTACAACCTACTCGCTCTTACGTTGAAAGCTTGATTGACATACATCGAGCCTACATCAATACTAATCATCCTAATTTTTTAAGTGCAACAGAAGCAATGGATGACATCATGAAAACGCGTAGAAAACGGAATCAAGAGTTATTGAAAAGTAAGTTGTCTCAACAGGAGAATGGACAAACCAACGGTATTAATGGTACTTCATCTATCTCTTCGAATATAGATCAAGATTCTGCTAAAAACAGTGACTACGATGATGATGGTATCGACGCAGAATCGAAGCAAACGAAGGACAAATTTTTAAATTATTTCTTTGGCAAGGATAAAAAGGGTCAACCTGTGTTCGATGCATCAGACAAGAAAAGATCCATTGCCGGTGATGGAAATATTGAAGATTTTAGAAATTTACAAATATCAGATTTTTCACTGGGCGATATAGATGACCTTGAAAACGCTGAACCTCCACTGACCGAGAGAGAAGAATTGGAGTGCGAATTAATTAAACGTCTGATTGTTTCATACTTTGATATTATAAGAGAAATGATTGAAGATCAAGTACCAAAGGCAGTTATGTGTTTACTCGTCAATTATTGTAAGGATTCTGTTCAAAACAGATTGGTAACCAAACTCTACAAAGAAACACTGTTTGAAGAACTTTTAGTTGAGGATCAAACTTTAGCTCAAGATAGAGAACTATGTGTGAAATCACTCGGAGTTTATAAAAAGGCTGCAACCCTTATTAGTAATATTCTGTAA","protein_sequence":"MASLEDLIPTVNKLQDVMYDSGIDTLDLPILAVVGSQSSGKSSILETLVGRDFLPRGTGIVTRRPLVLQLNNISPNSPLIEEDDNSVNPHDEVTKISGFEAGTKPLEYRGKERNHADEWGEFLHIPGKRFYDFDDIKREIENETARIAGKDKGISKIPINLKVFSPHVLNLTLVDLPGITKVPIGEQPPDIEKQIKNLILDYIATPNCLILAVSPANVDLVNSESLKLAREVDPQGKRTIGVITKLDLMDSGTNALDILSGKMYPLKLGFVGVVNRSQQDIQLNKTVEESLDKEEDYFRKHPVYRTISTKCGTRYLAKLLNQTLLSHIRDKLPDIKTKLNTLISQTEQELARYGGVGATTNESRASLVLQLMNKFSTNFISSIDGTSSDINTKELCGGARIYYIYNNVFGNSLKSIDPTSNLSVLDVRTAIRNSTGPRPTLFVPELAFDLLVKPQIKLLLEPSQRCVELVYEELMKICHKCGSAELARYPKLKSMLIEVISELLRERLQPTRSYVESLIDIHRAYINTNHPNFLSATEAMDDIMKTRRKRNQELLKSKLSQQENGQTNGINGTSSISSNIDQDSAKNSDYDDDGIDAESKQTKDKFLNYFFGKDKKGQPVFDASDKKRSIAGDGNIEDFRNLQISDFSLGDIDDLENAEPPLTEREELECELIKRLIVSYFDIIREMIEDQVPKAVMCLLVNYCKDSVQNRLVTKLYKETLFEELLVEDQTLAQDRELCVKSLGVYKKAATLISNIL"},{"created_at":"2011-06-14T19:36:51.000Z","updated_at":"2011-06-14T19:36:51.000Z","name":"mRNA-capping enzyme subunit alpha","uniprot_id":"Q01159","uniprot_name":"MCE1_YEAST","enzyme":true,"transporter":false,"gene_name":"CEG1","num_residues":459,"molecular_weight":"52763.80078","theoretical_pi":"5.56","general_function":"Involved in mRNA guanylyltransferase activity","specific_function":"Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate","reactions":[{"id":2858,"direction":"\u003e","locations":"Nucleus","altext":"GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"D10263","genbank_protein_id":"529647","gene_card_id":"CEG1","chromosome_location":"chromosome 7","locus":"YGL130W","synonyms":["GTP--RNA guanylyltransferase","GTase","mRNA guanylyltransferase"],"enzyme_classes":["2.7.7.50"],"go_classes":[{"category":"Component","description":" methyltransferase complex"},{"category":"Component","description":" mRNA cap methyltransferase complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" guanylyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" RNA guanylyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" mRNA guanylyltransferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Function","description":" protein binding"},{"category":"Process","description":" mRNA capping"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" RNA processing"},{"category":"Process","description":" mRNA processing"}],"pfams":[{"name":"mRNA_cap_C","identifier":"PF03919"},{"name":"mRNA_cap_enzyme","identifier":"PF01331"}],"pathways":[],"gene_sequence":"ATGGTTTTAGCAATGGAAAGTAGAGTGGCACCGGAAATTCCTGGGCTCATTCAACCTGGGAATGTCACGCAAGACTTGAAGATGATGGTCTGTAAATTATTGAATTCCCCAAAACCTACGAAAACATTCCCTGGTTCCCAGCCTGTGTCCTTTCAGCATTCTGATGTGGAAGAGAAGCTGCTTGCGCATGATTACTACGTTTGTGAGAAAACAGATGGTCTGCGGGTGTTGATGTTTATAGTGATAAATCCTGTGACGGGTGAGCAAGGATGCTTTATGATTGATAGGGAAAATAACTATTATCTGGTTAATGGATTTAGGTTTCCCAGATTACCCCAAAAGAAGAAAGAAGAGCTGCTAGAGACTCTTCAAGATGGCACCTTATTAGATGGTGAACTTGTCATACAAACTAACCCAATGACAAAATTACAAGAGTTGCGTTATTTAATGTTCGATTGTCTTGCTATCAATGGTAGATGTCTCACACAATCACCAACAAGTTCTAGACTAGCCCACCTTGGAAAAGAATTTTTTAAACCATACTTCGATTTAAGAGCAGCGTACCCTAATCGTTGTACTACTTTTCCGTTCAAAATTTCCATGAAACATATGGATTTCAGTTACCAATTAGTAAAAGTTGCTAAAAGTTTAGATAAACTACCACATCTTTCTGATGGTCTGATATTTACTCCTGTGAAGGCACCTTACACTGCCGGCGGAAAAGATTCATTGTTATTAAAATGGAAGCCAGAACAAGAAAACACCGTGGACTTCAAATTGATTTTAGATATCCCAATGGTGGAGGATCCTTCTTTGCCTAAAGATGATCGGAACAGGTGGTATTACAATTATGACGTTAAGCCAGTTTTCAGCTTATATGTCTGGCAAGGCGGAGCTGATGTCAATTCACGTTTAAAACATTTCGACCAGCCTTTCGATAGGAAGGAATTTGAAATATTAGAAAGAACATACAGAAAATTTGCAGAGTTGAGCGTTTCAGATGAGGAATGGCAAAATTTGAAGAACCTAGAACAGCCATTAAATGGTAGAATAGTAGAGTGCGCAAAAAACCAAGAGACTGGGGCGTGGGAAATGTTAAGATTCAGGGATGATAAGTTAAATGGTAATCATACATCGGTGGTCCAGAAAGTTTTGGAGAGTATCAACGATTCAGTTTCATTGGAGGACCTCGAGGAAATTGTTGGTGATATTAAAAGGTGCTGGGACGAGAGAAGAGCAAATATGGCTGGTGGTAGTGGGAGACCACTACCGTCTCAAAGTCAAAATGCGACATTATCTACCTCTAAGCCAGTCCATTCACAGCCCCCAAGTAATGATAAGGAGCCAAAATATGTAGACGAGGATGATTGGTCGGATTAG","protein_sequence":"MVLAMESRVAPEIPGLIQPGNVTQDLKMMVCKLLNSPKPTKTFPGSQPVSFQHSDVEEKLLAHDYYVCEKTDGLRVLMFIVINPVTGEQGCFMIDRENNYYLVNGFRFPRLPQKKKEELLETLQDGTLLDGELVIQTNPMTKLQELRYLMFDCLAINGRCLTQSPTSSRLAHLGKEFFKPYFDLRAAYPNRCTTFPFKISMKHMDFSYQLVKVAKSLDKLPHLSDGLIFTPVKAPYTAGGKDSLLLKWKPEQENTVDFKLILDIPMVEDPSLPKDDRNRWYYNYDVKPVFSLYVWQGGADVNSRLKHFDQPFDRKEFEILERTYRKFAELSVSDEEWQNLKNLEQPLNGRIVECAKNQETGAWEMLRFRDDKLNGNHTSVVQKVLESINDSVSLEDLEEIVGDIKRCWDERRANMAGGSGRPLPSQSQNATLSTSKPVHSQPPSNDKEPKYVDEDDWSD"}]}