{"ymdb_id":"YMDB00553","created_at":"2011-05-29T18:30:25.000Z","updated_at":"2016-09-08T18:35:37.000Z","name":"lanosteryl palmitoleate","cas":null,"state":null,"melting_point":null,"description":"Lanosteryl palmitoleate is the palmitoleic acid ester of lanosterol. Lanosterol is a tetracyclic triterpenoid, which is the compound from which all steroids are derived.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"endoplasmic reticulum","synthesis_reference":null,"chebi_id":"52383","hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":"23107006","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2S,5S,7R,11R,14R,15R)-2,6,6,11,15-pentamethyl-14-[(2R)-6-methylhept-5-en-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-1(10)-en-5-yl (9Z)-hexadec-9-enoate","traditional_iupac":"lanosteryl palmitoleate","logp":"14.265804766666665","pka":null,"alogps_solubility":"2.33e-05 g/l","alogps_logp":"10.88","alogps_logs":"-7.45","acceptor_count":"1","donor_count":"0","rotatable_bond_count":"19","polar_surface_area":"26.3","refractivity":"209.2527","polarizability":"87.77643045463824","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-7.042705895821048","pka_strongest_acidic":null,"bioavailability":"0","number_of_rings":"4","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":[],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10672016,"citation":"Zweytick, D., Leitner, E., Kohlwein, S. D., Yu, C., Rothblatt, J., Daum, G. (2000). \"Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae.\" Eur J Biochem 267:1075-1082."}],"proteins":[{"created_at":"2011-05-26T16:23:25.000Z","updated_at":"2011-07-22T17:53:58.000Z","name":"Sterol O-acyltransferase 1","uniprot_id":"P25628","uniprot_name":"ARE1_YEAST","enzyme":true,"transporter":false,"gene_name":"ARE1","num_residues":610,"molecular_weight":"71612.5","theoretical_pi":"8.38","general_function":"Involved in O-acyltransferase activity","specific_function":"Acyl-CoA + cholesterol = CoA + cholesterol ester","reactions":[{"id":1255,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1256,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1257,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1258,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1259,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1260,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1261,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1262,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1263,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1264,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2413,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + cholesterol = CoA + cholesterol ester.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"182-202;229-249;264-284;371-391;409-429;535-555;590-610","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"AY692921","genbank_protein_id":"51013293","gene_card_id":"ARE1","chromosome_location":"chromosome 3","locus":"YCR048W","synonyms":["Sterol-ester synthase 1"],"enzyme_classes":["2.3.1.26"],"go_classes":[],"pfams":[{"name":"MBOAT","identifier":"PF03062"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"}],"gene_sequence":"ATGACGGAGACTAAGGATTTGTTGCAAGACGAAGAGTTTCTTAAGATCCGCAGACTCAATTCCGCAGAAGCCAACAAACGGCATTCGGTCACGTACGATAACGTGATCCTGCCACAGGAGTCCATGGAGGTTTCGCCACGGTCGTCTACCACGTCGCTGGTGGAGCCAGTGGAGTCGACTGAAGGAGTGGAGTCGACTGAGGCGGAACGTGTGGCAGGGAAGCAGGAGCAGGAGGAGGAGTACCCTGTGGACGCCCACATGCAAAAGTACCTTTCACACCTGAAGAGCAAGTCTCGGTCGAGGTTCCACCGAAAGGATGCTAGCAAGTATGTGTCGTTTTTTGGGGACGTGAGTTTTGATCCTCGCCCCACGCTCCTGGACAGCGCCATCAACGTGCCCTTCCAGACGACTTTCAAAGGTCCGGTGCTGGAGAAACAGCTCAAAAATTTACAGTTGACAAAGACCAAGACCAAGGCCACGGTGAAGACTACGGTGAAGACTACGGAGAAAACGGACAAGGCAGATGCCCCCCCAGGAGAAAAACTGGAGTCGAACTTTTCAGGGATCTACGTGTTCGCATGGATGTTCTTGGGCTGGATAGCCATCAGGTGCTGCACAGATTACTATGCGTCGTACGGCAGTGCATGGAATAAGCTGGAAATCGTGCAGTACATGACAACGGACTTGTTCACGATCGCAATGTTGGACTTGGCAATGTTCCTGTGCACTTTCTTCGTGGTTTTCGTGCACTGGCTGGTGAAAAAGCGGATCATCAACTGGAAGTGGACTGGGTTCGTTGCAGTGAGCATCTTCGAGTTGGCTTTCATCCCCGTGACGTTCCCCATTTACGTCTACTACTTTGATTTCAACTGGGTCACGAGAATCTTCCTGTTCCTGCACTCCGTGGTGTTTGTTATGAAGAGCCACTCGTTTGCCTTTTACAACGGGTATCTTTGGGACATAAAGCAGGAACTCGAGTACTCTTCCAAACAGTTGCAAAAATACAAGGAATCTTTGTCCCCAGAGACCCGCGAGATTCTGCAAAAAAGTTGCGACTTTTGCCTTTTCGAATTGAACTACCAGACCAAGGATAACGACTTCCCCAACAACATCAGTTGCAGCAATTTCTTCATGTTCTGTTTGTTCCCCGTCCTCGTGTACCAGATCAACTACCCAAGAACGTCGCGCATCAGATGGAGGTATGTGTTGGAGAAGGTGTGCGCCATCATTGGCACCATCTTCCTCATGATGGTCACGGCACAGTTCTTCATGCACCCGGTGGCCATGCGCTGTATCCAGTTCCACAACACGCCCACCTTCGGCGGCTGGATCCCCGCCACGCAAGAGTGGTTCCACCTGCTCTTCGACATGATTCCGGGCTTCACTGTTCTGTACATGCTCACGTTTTACATGATATGGGACGCTTTATTGAATTGCGTGGCGGAGTTGACCAGGTTTGCGGACAGATATTTCTACGGCGACTGGTGGAATTGCGTTTCGTTTGAAGAGTTTAGCAGAATCTGGAACGTCCCCGTTCACAAATTTTTACTAAGACACGTGTACCACAGCTCCATGGGCGCATTGCATTTGAGCAAGAGCCAAGCTACATTATTTACTTTTTTCTTGAGTGCCGTGTTCCACGAAATGGCCATGTTCGCCATTTTCAGAAGGGTTAGAGGATATCTGTTCATGTTCCAACTGTCGCAGTTTGTGTGGACTGCTTTGAGCAACACCAAGTTTCTACGGGCAAGACCGCAGTTGTCCAACGTTGTCTTTTCGTTTGGTGTCTGTTCAGGGCCCAGTATCATTATGACGTTGTACCTGACCTTATGA","protein_sequence":"MTETKDLLQDEEFLKIRRLNSAEANKRHSVTYDNVILPQESMEVSPRSSTTSLVEPVESTEGVESTEAERVAGKQEQEEEYPVDAHMQKYLSHLKSKSRSRFHRKDASKYVSFFGDVSFDPRPTLLDSAINVPFQTTFKGPVLEKQLKNLQLTKTKTKATVKTTVKTTEKTDKADAPPGEKLESNFSGIYVFAWMFLGWIAIRCCTDYYASYGSAWNKLEIVQYMTTDLFTIAMLDLAMFLCTFFVVFVHWLVKKRIINWKWTGFVAVSIFELAFIPVTFPIYVYYFDFNWVTRIFLFLHSVVFVMKSHSFAFYNGYLWDIKQELEYSSKQLQKYKESLSPETREILQKSCDFCLFELNYQTKDNDFPNNISCSNFFMFCLFPVLVYQINYPRTSRIRWRYVLEKVCAIIGTIFLMMVTAQFFMHPVAMRCIQFHNTPTFGGWIPATQEWFHLLFDMIPGFTVLYMLTFYMIWDALLNCVAELTRFADRYFYGDWWNCVSFEEFSRIWNVPVHKFLLRHVYHSSMGALHLSKSQATLFTFFLSAVFHEMAMFAIFRRVRGYLFMFQLSQFVWTALSNTKFLRARPQLSNVVFSFGVCSGPSIIMTLYLTL"}]}