{"ymdb_id":"YMDB00537","created_at":"2011-05-29T18:28:25.000Z","updated_at":"2016-09-12T20:54:19.000Z","name":"hexacosanoyl-CoA","cas":null,"state":"Solid","melting_point":null,"description":"Hexacosanoyl-CoA is a coenzyme A derivative of hexacosanoic acid acid. Fatty acids must be activated with CoA before any chemical modification can be applied. Also fatty acid metabolic intermediates will also exists as CoA derivatives until the CoA is enzymatically cleaved. The fatty acid group is linked to the terminal thoil moiety of CoA.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"lipid particle;endoplasmic reticulum;peroxisome;cytoplasm","synthesis_reference":null,"chebi_id":"52966","hmdb_id":null,"kegg_id":null,"pubchem_id":"25246198","cs_id":"23107092","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[(3R)-3-[(2-{[2-(hexacosanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid","traditional_iupac":"cerotoyl-coa","logp":"5.043996028852043","pka":"1.9001207347761846","alogps_solubility":"2.48e-02 g/l","alogps_logp":"4.87","alogps_logs":"-4.67","acceptor_count":"17","donor_count":"9","rotatable_bond_count":"44","polar_surface_area":"363.6299999999999","refractivity":"282.6579","polarizability":"123.71002173313691","formal_charge":"0","physiological_charge":"-4","pka_strongest_basic":"4.006053268556904","pka_strongest_acidic":"0.8209787813398228","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["C26:0-CoA","C26:0-coenzyme A","cerotoyl-CoA","cerotoyl-coenzyme A","hexacosanoyl-CoA (N-C26:0CoA)","hexacosanoyl-coenzyme A"],"pathways":[{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10900202,"citation":"Mao, C., Xu, R., Bielawska, A., Szulc, Z. M., Obeid, L. M. (2000). \"Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide.\" J Biol Chem 275:31369-31378."},{"pubmed_id":9872981,"citation":"Jiang, J. C., Kirchman, P. A., Zagulski, M., Hunt, J., Jazwinski, S. M. (1998). \"Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.\" Genome Res 8:1259-1272."}],"proteins":[{"created_at":"2011-05-24T21:19:36.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Alkaline ceramidase YDC1","uniprot_id":"Q02896","uniprot_name":"YDC1_YEAST","enzyme":true,"transporter":false,"gene_name":"YDC1","num_residues":317,"molecular_weight":"37230.5","theoretical_pi":"7.17","general_function":"Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides","specific_function":"Catalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"43-60;67-89;99-121;134-156;160-182;203-225;240-262","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein","genbank_gene_id":"AF214455","genbank_protein_id":"10764171","gene_card_id":"YDC1","chromosome_location":"chromosome 16","locus":"YPL087W","synonyms":[],"enzyme_classes":["3.5.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" membrane lipid metabolic process"},{"category":"Process","description":" sphingolipid metabolic process"},{"category":"Process","description":" sphingoid metabolic process"},{"category":"Process","description":" ceramide metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"aPHC","identifier":"PF05875"}],"pathways":[],"gene_sequence":"ATGCTGTTCAGCTGGCCTTATCCAGAAGCCCCGATTGAAGGTTATTGGGGCAAGCCAACTTCTCTGATTGATTGGTGCGAGGAGAATTATGTCGTATCCCCCTATATTGCAGAATGGTCAAATACTATTACCAATAGTATATTCTTAATGACCGCCTTCTATTCTACATATAGCGCTTGGCGTAATAAGTTAGAAACAAGGTATATATTGATAGGAATGGGGTTCTCGCTGGTTGGTATTGGTTCGTGGTTATTTCATATGACTTTACAGTATCGTTATCAATTGCTAGACGAACTACCAATGCTGTATGCGACCATCATCCCATCGTGGAGTATTTTTGCAGAAACTCAAGAAATCTTGATTAAGGATGAGAAGAAAAGGAAGGAAAGCTCATTTAGAATCCAAATGGTCATTTCTTTTATCATGTGTGGTATAGTCACCATTTTAACCTGGATTTACGTTGTCGTCCAAAAGCCAGCAATTTTCCAAGTCCTTTATGGTATATTGACGCTTCTAGTTGTGGTTCTTTCTGGCTGGCTGACCTACTATCACGTTCATGATTCATTTGCAAAGAAAAATCTTTTTATTACTATGGTTATGGGCATGATTCCTTTTGTCATTGGGTTCATTTGCTGGCAACTAGATATTCACCTGTGTTCTTTTTGGATCTATATCCGGAGAACATATTTGGCCCTGCCATTAGGTGTTCTATTGGAACTGCATGCTTGGTGGCATCTTTTGACCGGTACTGGTGTCTATATCTTCGTCGTGTATTTGCAATATTTGAGAATATTAACCCATGGAAATCCAAATGACTTCTTATTTATATGGAGGTGGGGATTTTTCCCTGAGCTGGTAAGAAAGGGCTTACCGATTGGTACTTCTTATTCACTGGAGTATCTGGGGCCAATTGTAAATACACAGGTAGATGATGAAACAAAAAAGAATAACTAA","protein_sequence":"MLFSWPYPEAPIEGYWGKPTSLIDWCEENYVVSPYIAEWSNTITNSIFLMTAFYSTYSAWRNKLETRYILIGMGFSLVGIGSWLFHMTLQYRYQLLDELPMLYATIIPSWSIFAETQEILIKDEKKRKESSFRIQMVISFIMCGIVTILTWIYVVVQKPAIFQVLYGILTLLVVVLSGWLTYYHVHDSFAKKNLFITMVMGMIPFVIGFICWQLDIHLCSFWIYIRRTYLALPLGVLLELHAWWHLLTGTGVYIFVVYLQYLRILTHGNPNDFLFIWRWGFFPELVRKGLPIGTSYSLEYLGPIVNTQVDDETKKNN"},{"created_at":"2011-05-24T21:30:02.000Z","updated_at":"2011-07-22T17:54:55.000Z","name":"Very long-chain fatty acid transport protein","uniprot_id":"P38225","uniprot_name":"FAT1_YEAST","enzyme":false,"transporter":true,"gene_name":"FAT1","num_residues":669,"molecular_weight":"77140.29688","theoretical_pi":"8.52","general_function":"Involved in catalytic activity","specific_function":"May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised","reactions":[{"id":1514,"direction":"\u003c\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1515,"direction":"\u003c\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":3871,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006387","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"6-26;54-71;149-169;293-313","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"AF065148","genbank_protein_id":"3152696","gene_card_id":"FAT1","chromosome_location":"chromosome 2","locus":"YBR041W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"AMP-binding","identifier":"PF00501"}],"pathways":[{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"}],"gene_sequence":"ATGTCTCCCATACAGGTTGTTGTCTTTGCCTTGTCAAGGATTTTCCTGCTATTATTCAGACTTATCAAGCTAATTATAACCCCTATCCAGAAATCACTGGGTTATCTATTTGGTAATTATTTTGATGAATTAGACCGTAAATATAGATACAAGGAGGATTGGTATATTATTCCTTACTTTTTGAAAAGCGTGTTTTGTTATATCATTGATGTGAGAAGACATAGGTTTCAAAACTGGTACTTATTTATTAAACAGGTCCAACAAAATGGTGACCATTTAGCGATTAGTTACACCCGTCCCATGGCCGAAAAGGGAGAATTTCAACTCGAAACCTTTACGTATATTGAAACTTATAACATAGTGTTGAGATTGTCTCATATTTTGCATTTTGATTATAACGTTCAGGCCGGTGACTACGTGGCAATCGATTGTACTAATAAACCTCTTTTCGTATTTTTATGGCTTTCTTTGTGGAACATTGGGGCTATTCCAGCTTTTTTAAACTATAATACTAAAGGCACTCCGCTGGTTCACTCCCTAAAGATTTCCAATATTACGCAGGTATTTATTGACCCTGATGCCAGTAATCCGATCAGAGAATCGGAAGAAGAAATCAAAAACGCACTTCCTGATGTTAAATTAAACTATCTTGAAGAACAAGACTTAATGCATGAACTTTTAAATTCGCAATCACCGGAATTCTTACAACAAGACAACGTTAGGACACCACTAGGCTTGACCGATTTTAAACCCTCTATGTTAATTTATACATCTGGAACCACTGGTTTGCCTAAATCCGCTATTATGTCTTGGAGAAAATCCTCCGTAGGTTGTCAAGTTTTTGGTCATGTTTTACATATGACTAATGAAAGCACTGTGTTCACAGCCATGCCATTGTTCCATTCAACTGCTGCCTTATTAGGTGCGTGCGCCATTCTATCTCACGGTGGTTGCCTTGCGTTATCGCATAAATTTTCTGCCAGTACATTTTGGAAGCAAGTTTATTTAACAGGAGCCACGCACATCCAATATGTCGGAGAAGTCTGTAGATACCTGTTACATACGCCAATTTCTAAGTATGAAAAGATGCATAAGGTGAAGGTTGCTTATGGTAACGGGCTGAGACCTGACATCTGGCAGGACTTCAGGAAGAGGTTCAACATAGAAGTTATTGGTGAATTCTATGCCGCAACTGAAGCTCCTTTTGCTACAACTACCTTCCAGAAAGGTGACTTTGGAATTGGCGCATGTAGGAACTATGGTACTATAATTCAATGGTTTTTGTCATTCCAACAAACATTGGTAAGGATGGACCCAAATGACGATTCCGTTATATATAGAAATTCCAAGGGTTTCTGCGAAGTGGCCCCTGTTGGCGAACCAGGAGAAATGTTAATGAGAATCTTTTTCCCTAAAAAACCAGAAACATCTTTTCAAGGTTATCTTGGTAATGCCAAGGAAACAAAGTCCAAAGTTGTGAGGGATGTCTTCAGACGTGGCGATGCTTGGTATAGATGTGGAGATTTATTAAAAGCGGACGAATATGGATTATGGTATTTCCTTGATAGAATGGGTGATACTTTCAGATGGAAATCTGAAAATGTTTCCACTACTGAAGTAGAAGATCAGTTGACGGCCAGTAACAAAGAACAATATGCACAAGTTCTAGTTGTTGGTATTAAAGTACCTAAATATGAAGGTAGAGCTGGTTTTGCAGTTATTAAACTAACTGACAACTCTCTTGACATCACTGCAAAGACCAAATTATTAAATGATTCCTTGAGCCGGTTAAATCTACCGTCTTATGCTATGCCCCTATTTGTTAAATTTGTTGATGAAATTAAAATGACAGATAATCATAAAATTTTGAAGAAGGTTTATAGAGAGCAAAAATTACCAAAGGGTTTGGATGGAAATGACACTATTTTTTGGCTCAAGAATTACAAGCGCTATGAAGTCTTGACCGCTGCTGATTGGGAAGCCATCGATGCACAAACAATTAAATTATGA","protein_sequence":"MSPIQVVVFALSRIFLLLFRLIKLIITPIQKSLGYLFGNYFDELDRKYRYKEDWYIIPYFLKSVFCYIIDVRRHRFQNWYLFIKQVQQNGDHLAISYTRPMAEKGEFQLETFTYIETYNIVLRLSHILHFDYNVQAGDYVAIDCTNKPLFVFLWLSLWNIGAIPAFLNYNTKGTPLVHSLKISNITQVFIDPDASNPIRESEEEIKNALPDVKLNYLEEQDLMHELLNSQSPEFLQQDNVRTPLGLTDFKPSMLIYTSGTTGLPKSAIMSWRKSSVGCQVFGHVLHMTNESTVFTAMPLFHSTAALLGACAILSHGGCLALSHKFSASTFWKQVYLTGATHIQYVGEVCRYLLHTPISKYEKMHKVKVAYGNGLRPDIWQDFRKRFNIEVIGEFYAATEAPFATTTFQKGDFGIGACRNYGTIIQWFLSFQQTLVRMDPNDDSVIYRNSKGFCEVAPVGEPGEMLMRIFFPKKPETSFQGYLGNAKETKSKVVRDVFRRGDAWYRCGDLLKADEYGLWYFLDRMGDTFRWKSENVSTTEVEDQLTASNKEQYAQVLVVGIKVPKYEGRAGFAVIKLTDNSLDITAKTKLLNDSLSRLNLPSYAMPLFVKFVDEIKMTDNHKILKKVYREQKLPKGLDGNDTIFWLKNYKRYEVLTAADWEAIDAQTIKL"},{"created_at":"2011-05-24T21:41:52.000Z","updated_at":"2011-07-22T17:53:57.000Z","name":"Acyl-coenzyme A oxidase","uniprot_id":"P13711","uniprot_name":"ACOX_YEAST","enzyme":true,"transporter":false,"gene_name":"POX1","num_residues":748,"molecular_weight":"84041.39844","theoretical_pi":"8.7","general_function":"Involved in acyl-CoA dehydrogenase activity","specific_function":"Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)","reactions":[{"id":1249,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1250,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1251,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1252,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1253,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1254,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2392,"direction":"\u003e","locations":"Peroxisome","altext":"Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Peroxisome","genbank_gene_id":"M27515","genbank_protein_id":"172217","gene_card_id":"POX1","chromosome_location":"chromosome 7","locus":"YGL205W","synonyms":["Acyl-CoA oxidase"],"enzyme_classes":["1.3.3.6"],"go_classes":[{"category":"Component","description":" microbody"},{"category":"Component","description":" peroxisome"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" binding"},{"category":"Function","description":" acyl-CoA dehydrogenase activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor"},{"category":"Function","description":" acyl-CoA oxidase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" fatty acid catabolic process"},{"category":"Process","description":" fatty acid beta-oxidation"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"ACOX","identifier":"PF01756"},{"name":"Acyl-CoA_dh_M","identifier":"PF02770"}],"pathways":[{"name":"Fatty acid metabolism","kegg_map_id":"00071"},{"name":"alpha-Linolenic acid metabolism","kegg_map_id":"00592"},{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"}],"gene_sequence":"ATGACGAGACGTACTACTATTAATCCCGATTCGGTGGTTCTGAATCCTCAAAAATTTATCCAGAAAGAAAGGGCGGATTCGAAAATCAAAGTTGACCAAGTTAACACATTTTTAGAGTCATCCCCGGAGAGGAGAACTCTGACGCACGCCTTAATAGACCAAATAGTGAATGATCCTATATTGAAAACTGATACGGACTATTACGATGCTAAAAAAATGCAAGAGAGAGAAATTACTGCCAAAAAAATAGCTAGGCTTGCTAGTTATATGGAGCACGATATCAAAACAGTGCGCAAACACTTTCGCGACACTGACCTGATGAAAGAGTTGCAAGCAAATGATCCAGACAAAGCTTCGCCTTTAACAAACAAAGACCTTTTTATATTCGATAAGAGATTGTCACTTGTAGCAAATATTGATCCTCAATTGGGTACGCGCGTGGGTGTACACTTGGGGCTATTTGGTAATTGTATCAAGGGCAATGGTACTGATGAGCAAATCCGGTATTGGTTGCAGGAGAGAGGTGCCACTTTGATGAAAGGTATATATGGCTGTTTTGCAATGACTGAGTTAGGACATGGTTCCAATGTTGCCCAGCTGCAGACTAGGGCTGTGTACGATAAGCAAAATGATACTTTTGTAATTGATACACCTGATCTAACTGCCACCAAATGGTGGATTGGTGGGGCTGCCCATTCTGCCACGCACGCTGCCGTGTACGCCAGATTGATCGTTGAAGGTAAAGACTACGGTGTAAAAACATTCGTTGTTCCTCTGAGAGACCCTTCGACTTTCCAACTGTTAGCTGGTGTTTCCATAGGGGATATTGGAGCGAAGATGGGTCGTGACGGTATTGATAATGGCTGGATCCAGTTCAGAAACGTAGTTATCCCTAGAGAATTTATGCTAAGTAGATTTACCAAAGTTGTCCGTTCTCCAGATGGTTCAGTCACCGTCAAAACTGAGCCACAATTGGATCAAATTTCTGGTTATAGTGCATTGTTAAGTGGTAGAGTTAACATGGTCATGGATTCATTTAGGTTTGGCTCCAAATTTGCTACTATTGCTGTACGTTACGCGGTTGGTCGTCAGCAATTCGCACCTAGAAAGGGATTGTCTGAAACACAATTAATCGACTATCCCCTTCACCAATATCGTGTTTTACCACAATTGTGTGTTCCATATTTGGTGTCACCTGTAGCTTTTAAGTTAATGGACAACTATTATTCCACTTTGGACGAGTTATACAACGCTTCCTCATCTGCATACAAAGCTGCTCTGGTTACCGTGAGTAAAAAGTTGAAGAATTTATTTATTGATAGCGCCACGTTGAAAGCCACCAATACTTGGTTAATTGCTACACTGATTGATGAGTTGAGACAGACTTGCGGAGGACATGGGTATTCACAGTATAACGGATTTGGTAAAGGCTATGACGACTGGGTGGTTCAGTGCACATGGGAGGGTGATAATAATGTTTTATCTTTAACTTCAGCAAAATCAATATTGAAAAAATTTATCGATTCAGCCACAAAGGGTAGATTTGACAACACACTGGATGTGGACTCATTCTCTTACTTAAAACCTCAGTACATAGGATCTGTGGTTTCTGGAGAAATAAAGAGTGGTTTAAAGGAGTTGGGTGATTATACTGAAATTTGGTCTATCACCTTAATCAAATTACTGGCACATATTGGTACTTTAGTTGAAAAATCAAGAAGTATTGATAGCGTTTCTAAGCTTTTAGTCTTAGTATCCAAATTTCATGCCTTGCGCTGCATGTTGAAAACCTATTACGACAAGTTAAACTCTCGTGATTCACATATTTCCGATGAAATTACAAAGGAATCTATGTGGAATGTTTATAAGTTATTTTCCTTGTATTTTATTGACAAGCATTCCGGAGAATTCCAACAATTCAAGATCTTCACTCCTGATCAGATCTCTAAAGTTGTGCAGCCACAACTATTGGCTCTTTTGCCAATTGTGAGGAAAGACTGTATAGGTCTGACAGACTCCTTTGAATTACCTGACGCGATGTTAAATTCTCCTATAGGTTACTTTGATGGCGATATCTATCACAATTACTTCAATGAAGTTTGCCGCAATAATCCAGTGGAGGCAGATGGGGCAGGGAAGCCTTCTTATCATGCGCTGTTGAGCAGCATGCTCGGTAGAGGTTTCGAATTTGACCAAAAGTTAGGTGGTGCAGCTAATGCGGAAATTTTATCGAAAATAAACAAGTGA","protein_sequence":"MTRRTTINPDSVVLNPQKFIQKERADSKIKVDQVNTFLESSPERRTLTHALIDQIVNDPILKTDTDYYDAKKMQEREITAKKIARLASYMEHDIKTVRKHFRDTDLMKELQANDPDKASPLTNKDLFIFDKRLSLVANIDPQLGTRVGVHLGLFGNCIKGNGTDEQIRYWLQERGATLMKGIYGCFAMTELGHGSNVAQLQTRAVYDKQNDTFVIDTPDLTATKWWIGGAAHSATHAAVYARLIVEGKDYGVKTFVVPLRDPSTFQLLAGVSIGDIGAKMGRDGIDNGWIQFRNVVIPREFMLSRFTKVVRSPDGSVTVKTEPQLDQISGYSALLSGRVNMVMDSFRFGSKFATIAVRYAVGRQQFAPRKGLSETQLIDYPLHQYRVLPQLCVPYLVSPVAFKLMDNYYSTLDELYNASSSAYKAALVTVSKKLKNLFIDSASLKATNTWLIATLIDELRQTCGGHGYSQYNGFGKGYDDWVVQCTWEGDNNVLSLTSAKSILKKFIDSATKGRFDNTLDVDSFSYLKPQYIGSVVSGEIKSGLKELGDYTEIWSITLIKLLAHIGTLVEKSRSIDSVSKLLVLVSKFHALRCMLKTYYDKLNSRDSHISDEITKESMWNVYKLFSLYFIDKHSGEFQQFKIFTPDQISKVVQPQLLALLPIVRKDCIGLTDSFELPDAMLNSPIGYFDGDIYHNYFNEVCRNNPVEADGAGKPSYHALLSSMLGRGFEFDQKLGGAANAEILSKINK"},{"created_at":"2011-05-24T21:46:35.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAG1","uniprot_id":"P38703","uniprot_name":"LAG1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAG1","num_residues":411,"molecular_weight":"48454.10156","theoretical_pi":"9.17","general_function":"Involved in protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;177-197;212-232;252-272;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"AY558514","genbank_protein_id":"45270918","gene_card_id":"LAG1","chromosome_location":"chromosome 8","locus":"YHL003C","synonyms":["Longevity assurance factor 1","Longevity assurance gene 1 protein","Longevity assurance protein 1"],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGACATCAGCTACGGACAAATCTATCGATAGGTTAGTTGTTAATGCAAAAACAAGAAGACGAAACTCTTCCGTGGGTAAAATTGATTTAGGTGATACAGTTCCTGGCTTTGCAGCCATGCCTGAAAGTGCTGCCTCTAAAAATGAGGCCAAAAAAAGGATGAAAGCCTTGACTGGTGACTCTAAAAAGGATAGTGACCTACTGTGGAAGGTTTGGTTTTCATATAGAGAAATGAATTACCGTCATAGTTGGTTGACACCATTCTTCATACTTGTATGCGTGTATAGCGCGTACTTTTTATCTGGGAATAGAACAGAATCAAACCCGCTGCACATGTTCGTAGCCATATCATATCAAGTTGATGGCACAGACTCATATGCAAAAGGTATCAAAGATTTGAGTTTTGTGTTTTTCTACATGATTTTCTTCACATTTTTACGTGAGTTTTTGATGGATGTTGTAATTCGACCATTCACGGTATACCTAAATGTTACTTCCGAGCATCGTCAAAAGCGTATGCTAGAACAAATGTATGCCATATTTTATTGCGGAGTTTCAGGGCCCTTTGGTCTTTATATTATGTACCATAGTGATTTGTGGTTGTTCAAGACAAAACCAATGTACAGAACATATCCTGTTATAACCAATCCGTTCTTGTTTAAGATATTTTACTTGGGTCAAGCGGCATTTTGGGCGCAACAGGCTTGTGTTCTTGTTCTACAATTAGAAAAGCCAAGAAAGGATTACAAGGAATTGGTTTTTCATCACATTGTGACATTATTATTAATTTGGTCATCATATGTTTTCCATTTTACCAAAATGGGATTGGCTATCTATATTACTATGGATGTGTCAGATTTTTTCCTTTCTTTGTCTAAGACATTAAACTATCTGAATTCTGTATTTACTCCCTTTGTGTTCGGCTTGTTCGTGTTCTTTTGGATCTATCTGCGCCATGTCGTGAATATCAGAATATTATGGTCAGTCTTAACAGAATTCCGTCATGAAGGTAATTATGTGTTGAATTTTGCCACACAACAATACAAATGTTGGATTTCGTTGCCAATTGTATTTGTACTAATTGCTGCGTTACAATTAGTTAACCTGTATTGGCTGTTTTTAATTCTTAGAATCTTGTACAGATTGATATGGCAAGGTATCCAAAAGGACGAAAGAAGTGACAGTGATTCTGATGAGAGCGCTGAAAATGAAGAATCTAAGGAAAAGTGTGAATAA","protein_sequence":"MTSATDKSIDRLVVNAKTRRRNSSVGKIDLGDTVPGFAAMPESAASKNEAKKRMKALTGDSKKDSDLLWKVWFSYREMNYRHSWLTPFFILVCVYSAYFLSGNRTESNPLHMFVAISYQVDGTDSYAKGIKDLSFVFFYMIFFTFLREFLMDVVIRPFTVYLNVTSEHRQKRMLEQMYAIFYCGVSGPFGLYIMYHSDLWLFKTKPMYRTYPVITNPFLFKIFYLGQAAFWAQQACVLVLQLEKPRKDYKELVFHHIVTLLLIWSSYVFHFTKMGLAIYITMDVSDFFLSLSKTLNYLNSVFTPFVFGLFVFFWIYLRHVVNIRILWSVLTEFRHEGNYVLNFATQQYKCWISLPIVFVLIAALQLVNLYWLFLILRILYRLIWQGIQKDERSDSDSDESAENEESKEKCE"},{"created_at":"2011-05-26T16:06:16.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Alkaline ceramidase YPC1","uniprot_id":"P38298","uniprot_name":"YPC1_YEAST","enzyme":true,"transporter":false,"gene_name":"YPC1","num_residues":316,"molecular_weight":"36419.39844","theoretical_pi":"8.41","general_function":"Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides","specific_function":"Hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine. Prefers phytoceramide. Has also reverse hydrolysis activity, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide","reactions":[{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"69-89;94-114;136-156;161-181;196-216;229-249","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein","genbank_gene_id":"AF191745","genbank_protein_id":"7248652","gene_card_id":"YPC1","chromosome_location":"chromosome 2","locus":"YBR183W","synonyms":[],"enzyme_classes":["3.5.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" membrane lipid metabolic process"},{"category":"Process","description":" sphingolipid metabolic process"},{"category":"Process","description":" sphingoid metabolic process"},{"category":"Process","description":" ceramide metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"aPHC","identifier":"PF05875"}],"pathways":[],"gene_sequence":"ATGGGAATATTTCGTTGGAACTATCCAGAGAGTTCTGTCCCCGGCGTTTGGGGAGAAACAACTTCCACTATTGACTGGTGTGAGGAGAACTATGTCGTTTCTCCCTATATTGCCGAGTGGTCAAACACTTTAACTAACAGCGTATTCATACTGTCAGCGATTTACACAACTTACTCTGCTTACAAGAATAAATTAGAAAAAAGGTTTTTACTTATTGGCTTCGGGTACGGTTTGGTCGGAGTAGGATCATGGCTATTTCATATGACACTGAAGTATAGATTCCAACTATTGGATGAACTTCCAATGATATACGCCATGTGCATTCCGACATGGAGTTTAGTATGCGAGGCCAAAGAGGCATTACTTAACGGAGATAATCACAAGAAGGTTCCTCTATTTGAACAGATATTCATCGGCGTAATTATCGGCCTGGCCGTTACAACAGCAAGCATACTCTACGTTATTTACAAAAATGTCGATATCCATCAAATTTTGTTTGGCGTACAGATTGTAGTTGTGGCTGCTACTGCAGGAAGTTTGACGTACAGATACGTCCATGATCCACTTGCCAAAAGAAATCTCAAGGCTTCAATGGCGCTCGGCGCAATTTTGTTCTTATCTGGCTACATTTCGTGGCTACTTGATATACACTATTGTTCGTTCTGGGTGCACGTTAGAAGAAGTATTTTGGCTTTACCACTTGGTGTACTGCTTGAACCACACGGATGGTGGCATATATTAACTGGTATGGGGATTTATTTCTACATTGTTTCTTTGGAACATTTAAGGGTCATTACGCTCAACGTCAGCTGCAATTACCAGTTCATCTGGAGATGGAAAGTCTTCCCTGAACTGATATGGAAAGGGCGCAAACCCTCAACAAGATATTCACTTGAACTATTTGGCCCATACGTAGAAGATCAATCAATTGAAGTTAAAAAGGAGAAGTAA","protein_sequence":"MGIFRWNYPESSVPGVWGETTSTIDWCEENYVVSPYIAEWSNTLTNSVFILSAIYTTYSAYKNKLEKRFLLIGFGYGLVGVGSWLFHMTLKYRFQLLDELPMIYAMCIPTWSLVCEAKEALLNGDNHKKVPLFEQIFIGVIIGLAVTTASILYVIYKNVDIHQILFGVQIVVVAATAGSLTYRYVHDPLAKRNLKASMALGAILFLSGYISWLLDIHYCSFWVHVRRSILALPLGVLLEPHGWWHILTGMGIYFYIVSLEHLRVITLNVSCNYQFIWRWKVFPELIWKGRKPSTRYSLELFGPYVEDQSIEVKKEK"},{"created_at":"2011-05-26T16:11:34.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAC1","uniprot_id":"P28496","uniprot_name":"LAC1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAC1","num_residues":418,"molecular_weight":"48991.60156","theoretical_pi":"9.81","general_function":"Involved in identical protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;173-193;222-242;260-280;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z28008","genbank_protein_id":"485983","gene_card_id":"LAC1","chromosome_location":"chromosome 11","locus":"YKL008C","synonyms":[],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGTCGACAATAAAGCCAAGCCCTTCAAACAACAATTTGAAAGTGAGGTCAAGACCAAGACGCAAGTCTTCCATAGGTAAGATCGACCTCGGGGACACTGTACCTAGTTTAGGTACTATGTTCGAGACAAAAGAATCTAAAACGGCTGCTAAAAGGCGTATGCAGAGATTATCTGAAGCCACCAAAAATGATAGCGACCTGGTCAAGAAAATCTGGTTTTCATTCCGAGAGATAAGTTACCGTCATGCCTGGATAGCTCCCTTGATGATTTTAATCGCGGTATATAGTGCCTATTTCACTTCTGGTAACACTACAAAGACAAATGTGTTACATAGATTTGTCGCTGTGTCATACCAAATAGGTGATACCAACGCATATGGTAAAGGTATTAACGATTTGTGCTTTGTATTTTACTATATGATTTTTTTCACATTCTTACGTGAATTCCTAATGGATGTTGTCATTAGACCGTTCGCTATTAGGTTACACGTCACTTCTAAGCACAGAATAAAAAGAATCATGGAACAAATGTACGCTATTTTCTACACCGGTGTTTCCGGTCCTTTCGGGATATATTGTATGTACCATTCGGATTTATGGTTTTTCAACACAAAGGCAATGTACAGAACATATCCAGATTTCACTAATCCCTTCTTATTCAAGGTATTCTATTTGGGTCAAGCTGCATTTTGGGCTCAACAAGCCTGCATTCTTGTATTGCAACTAGAAAAGCCAAGAAAAGATCATAACGAGTTGACTTTCCATCATATTGTTACTTTACTATTGATTTGGTCTTCCTACGTATTTCATTTCACTAAAATGGGACTGCCAATCTATATCACAATGGATGTTTCTGATTTTCTTTTGTCATTCTCCAAAACTCTAAATTATTTGGACTCTGGATTGGCTTTTTTTTCTTTTGCTATCTTTGTTGTTGCGTGGATTTATTTGCGTCATTACATAAATTTAAAGATCCTATGGTCCGTTTTAACGCAATTTCGCACGGAAGGTAACTATGTCTTGAATTTTGCCACTCAGCAATATAAATGTTGGATTTCCTTACCAATTGTCTTTGTATTGATAGGCGCTTTGCAATTAGTGAATCTTTATTGGCTGTTCCTTATTTTTAGAGTTCTTTACAGGATTCTATGGAGAGGTATTCTCAAGGATGACAGAAGTGATAGTGAATCAGACGAAGAAAGTGATGAAAGTTCCACTACTCCAACTGACAGTACTCCAACGAAAAAGGATATTTGA","protein_sequence":"MSTIKPSPSNNNLKVRSRPRRKSSIGKIDLGDTVPSLGTMFETKESKTAAKRRMQRLSEATKNDSDLVKKIWFSFREISYRHAWIAPLMILIAVYSAYFTSGNTTKTNVLHRFVAVSYQIGDTNAYGKGINDLCFVFYYMIFFTFLREFLMDVVIRPFAIRLHVTSKHRIKRIMEQMYAIFYTGVSGPFGIYCMYHSDLWFFNTKAMYRTYPDFTNPFLFKVFYLGQAAFWAQQACILVLQLEKPRKDHNELTFHHIVTLLLIWSSYVFHFTKMGLPIYITMDVSDFLLSFSKTLNYLDSGLAFFSFAIFVVAWIYLRHYINLKILWSVLTQFRTEGNYVLNFATQQYKCWISLPIVFVLIGALQLVNLYWLFLIFRVLYRILWRGILKDDRSDSESDEESDESSTTPTDSTPTKKDI"},{"created_at":"2011-05-27T07:15:52.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Enoyl-[acyl-carrier protein] reductase [NADPH, B-specific], mitochondrial","uniprot_id":"P38071","uniprot_name":"ETR1_YEAST","enzyme":true,"transporter":false,"gene_name":"ETR1","num_residues":380,"molecular_weight":"42066.5","theoretical_pi":"9.49","general_function":"Involved in zinc ion binding","specific_function":"Required for respiration and the maintenance of the mitochondrial compartment. May have a role in the mitochondrial synthesis of fatty acids","reactions":[{"id":2805,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"Acyl-[acyl-carrier-protein] + NADP(+) = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2806,"direction":"\u003e","locations":" Multi-pass membrane protein.;Mitochondrion matrix;Endoplasmic reticulum membrane","altext":"Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":3883,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006390","source":"Smpdb"},{"id":3884,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006395","source":"Smpdb"},{"id":3885,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006399","source":"Smpdb"},{"id":3886,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006403","source":"Smpdb"},{"id":3887,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006407","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY557872","genbank_protein_id":"45269635","gene_card_id":"ETR1","chromosome_location":"chromosome 2","locus":"YBR026C","synonyms":["Mitochondrial respiratory function protein 1","Trans-2-enoyl-CoA reductase"],"enzyme_classes":["1.3.1.10","1.3.1.38"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[],"pathways":[{"name":"Fatty acid elongation in mitochondria","kegg_map_id":"00062"},{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"}],"gene_sequence":"ATGCTTCCCACATTCAAACGTTACATGTCGTCCTCAGCTCATCAGATTCCCAAGCACTTCAAATCGCTCACCTATTCAACTCATGAAGTTGAGGATTGTACCAAGGTTTTGTCAGTGAAAAATTATACGCCTAAACAAGACTTATCTCAATCAATTGTGTTAAAAACTTTGGCCTTTCCCATAAACCCTTCGGATATCAATCAGTTGCAAGGAGTATACCCGTCTCGTCCAGAAAAGACATACGATTACTCCACAGATGAGCCAGCCGCTATCGCCGGTAATGAGGGTGTCTTTGAAGTTGTTTCTTTACCTTCGGGAAGTTCCAAGGGAGATTTGAAATTGGGTGACCGAGTTATCCCATTGCAGGCAAATCAAGGGACTTGGTCCAATTATAGAGTTTTCTCTAGTAGTTCTGATTTAATCAAGGTAAATGATTTGGATCTGTTTTCTGCGGCAACTGTATCTGTTAATGGTTGTACCGGTTTCCAATTAGTATCAGACTATATCGACTGGAACAGTAACGGTAATGAATGGATTATCCAAAATGCCGGTACATCTAGTGTATCAAAAATAGTTACGCAAGTAGCAAAAGCTAAAGGGATCAAAACATTAAGTGTTATACGTGACCGTGATAATTTTGATGAGGTAGCAAAAGTTTTGGAGGATAAGTATGGTGCTACGAAGGTTATTTCCGAATCGCAAAACAACGACAAGACTTTTGCCAAAGAAGTATTGTCCAAGATTTTGGGTGAAAATGCAAGGGTGAGGCTTGCCTTGAATTCTGTTGGAGGTAAATCCAGTGCATCAATAGCACGTAAGTTGGAAAATAATGCTTTGATGCTCACTTATGGAGGAATGTCAAAACAACCTGTAACTTTACCAACATCTCTACACATTTTCAAAGGCTTGACATCCAAAGGGTACTGGGTGACTGAAAAGAACAAAAAAAACCCCCAAAGCAAGATTGACACCATCAGTGATTTTATCAAAATGTATAATTATGGTCACATTATTTCACCAAGAGATGAAATTGAAACTCTTACCTGGAATACTAACACTACTACTGACGAACAGTTACTAGAACTAGTCAAAAAAGGTATAACTGGGAAGGGGAAGAAAAAAATGGTTGTTTTAGAATGGTAA","protein_sequence":"MLPTFKRYMSSSAHQIPKHFKSLIYSTHEVEDCTKVLSVKNYTPKQDLSQSIVLKTLAFPINPSDINQLQGVYPSRPEKTYDYSTDEPAAIAGNEGVFEVVSLPSGSSKGDLKLGDRVIPLQANQGTWSNYRVFSSSSDLIKVNDLDLFSAATVSVNGCTGFQLVSDYIDWNSNGNEWIIQNAGTSSVSKIVTQVAKAKGIKTLSVIRDRDNFDEVAKVLEDKYGATKVISESQNNDKTFAKEVLSKILGENARVRLALNSVGGKSSASIARKLENNALMLTYGGMSKQPVTLPTSLHIFKGLTSKGYWVTEKNKKNPQSKIDTISDFIKMYNYGHIISPRDEIETLTWNTNTTTDEQLLELVKKGITGKGKKKMVVLEW"},{"created_at":"2016-09-09T22:38:09.000Z","updated_at":"2016-09-09T22:38:09.000Z","name":"Ceramide synthase subunit LIP1","uniprot_id":"A6ZN14","uniprot_name":"LIP1","enzyme":false,"transporter":false,"gene_name":"LIP1","num_residues":null,"molecular_weight":"17206.535","theoretical_pi":null,"general_function":"lipid metabolic process","specific_function":"Component of the ceramide synthase complex required for synthesis of ceramides.","reactions":[{"id":3893,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006411","source":"Smpdb"},{"id":3894,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006414","source":"Smpdb"},{"id":3895,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006426","source":"Smpdb"},{"id":3896,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006514","source":"Smpdb"},{"id":3897,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006515","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"21-40","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"lipid metabolic process"},{"category":"Function","description":"integral component of membrane"},{"category":"Function","description":"endoplasmic reticulum membrane"}],"pfams":[],"pathways":[{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"},{"name":"Biosynthesis of unsaturated fatty acids (docosanoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (icosanoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (stearoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (tetracosanoyl-CoA)","kegg_map_id":null}],"gene_sequence":null,"protein_sequence":"MSQPTPIITTKSAAKPKPKIFNLFRVCFISLLLIAAVEYFKYGTRINYEWFHCTPIKEPQSGSVIKLWARGGPSCDKRGEYKTIVKRITRDYEPNDEHLSFCIIENDNVPPVHYPIHEDKGEPGYVAYVGYDTDSELVQELCADSTIYHM"}]}