{"ymdb_id":"YMDB00536","created_at":"2011-05-29T18:28:13.000Z","updated_at":"2016-09-12T20:56:45.000Z","name":"2-Acetamido-5-oxopentanoic acid","cas":null,"state":"Solid","melting_point":null,"description":"2-Acetamido-5-oxopentanoic acid is an intermediate in urea cycle and metabolism of amino groups. N-Acetyl-L-glutamate 5-semialdehyde is the second to last step in the synthesis of L-ornithine and is converted from N-acetyl-L-glutamate 5-phosphate via the enzyme N-acetyl-gamma-glutamyl-phosphate reductase [EC: 1.2.1.38]. It is then converted to N-acetylornithine via the enzyme acetylornithine aminotransferase [EC: 2.6.1.11].","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion","synthesis_reference":null,"chebi_id":"29123","hmdb_id":null,"kegg_id":"C01250","pubchem_id":"905","cs_id":"167387","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2S)-2-acetamido-5-oxopentanoic acid","traditional_iupac":"N-acetyl-5-oxo-L-norvaline","logp":"-1.2716316689999996","pka":"15.388045160344994","alogps_solubility":"1.86e+01 g/l","alogps_logp":"-0.43","alogps_logs":"-0.97","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"5","polar_surface_area":"83.47","refractivity":"39.8061","polarizability":"16.46435132967752","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-1.800772242586961","pka_strongest_acidic":"3.7240106316656503","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-acetamido-5-oxopentanoate","2-acetamido-5-oxovalerate","N-Acetyl-L-glutamate 5-semialdehyde"],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-24T20:44:30.000Z","updated_at":"2011-07-22T17:53:56.000Z","name":"Acetylornithine aminotransferase, mitochondrial","uniprot_id":"P18544","uniprot_name":"ARGD_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG8","num_residues":423,"molecular_weight":"46681.10156","theoretical_pi":"7.62","general_function":"Involved in transaminase activity","specific_function":"N(2)-acetyl-L-ornithine + 2-oxoglutarate = N- acetyl-L-glutamate 5-semialdehyde + L-glutamate","reactions":[{"id":1247,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2338,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3773,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006295","source":"Smpdb"},{"id":3773,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006295","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"M32795","genbank_protein_id":"171083","gene_card_id":"ARG8","chromosome_location":"chromosome 15","locus":"YOL140W","synonyms":["ACOAT"],"enzyme_classes":["2.6.1.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine metabolic process"}],"pfams":[{"name":"Aminotran_3","identifier":"PF00202"}],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"4-aminobutanoate degradation","kegg_map_id":null}],"gene_sequence":"ATGTTTAAAAGATATTTATCCAGTACGTCATCAAGAAGATTTACAAGCATTTTAGAGGAAAAGGCCTTTCAAGTGACCACTTACTCTAGACCTGAAGATCTATGTATAACTAGAGGTAAAAATGCAAAGCTGTATGATGACGTGAATGGTAAAGAATATATCGATTTCACCGCAGGTATTGCGGTGACCGCATTAGGCCATGCAAATCCTAAAGTGGCAGAAATTCTGCACCATCAGGCTAACAAACTGGTTCATTCCTCCAACCTTTACTTCACTAAGGAATGTTTGGATTTAAGTGAAAAGATTGTTGAAAAGACCAAGCAATTCGGTGGTCAACACGACGCCTCAAGAGTATTTTTATGTAATTCTGGTACGGAAGCAAATGAAGCTGCTTTGAAGTTTGCAAAGAAACATGGTATAATGAAAAATCCTAGCAAGCAAGGCATTGTTGCATTTGAGAACTCTTTTCATGGCCGTACTATGGGCGCTTTATCTGTCACTTGGAATAGTAAATATAGAACTCCTTTTGGGGATTTGGTTCCCCATGTCTCATTCTTAAATTTGAATGACGAAATGACCAAACTACAAAGTTATATCGAGACCAAAAAGGACGAGATTGCTGGTTTAATTGTCGAGCCCATACAAGGTGAAGGTGGGGTTTTTCCCGTAGAAGTTGAAAAGCTAACCGGATTGAAGAAAATATGTCAAGATAATGATGTGATTGTCATTCATGATGAAATTCAATGCGGTTTGGGCCGTTCAGGTAAACTATGGGCTCATGCTTATTTACCAAGTGAGGCTCATCCGGATATTTTTACATCTGCCAAAGCATTGGGAAATGGCTTCCCCATCGCTGCCACCATCGTCAATGAAAAAGTTAATAATGCTTTGAGAGTTGGTGACCACGGCACCACGTATGGTGGTAATCCGCTGGCCTGTTCTGTAAGCAACTATGTTTTGGATACCATAGCAGACGAAGCTTTTTTGAAACAAGTCTCTAAGAAGAGTGATATCTTACAAAAGCGCTTGCGCGAAATTCAAGCCAAATATCCAAATCAAATAAAGACTATCAGAGGAAAAGGTTTGATGCTTGGTGCTGAGTTCGTCGAACCACCCACCGAGGTCATCAAAAAGGCCAGAGAATTGGGACTTTTGATCATTACCGCTGGTAAGAGTACCGTTAGATTTGTTCCCGCATTAACGATTGAAGACGAACTAATCGAAGAAGGGATGGATGCTTTTGAAAAGGCTATTGAAGCGGTTTACGCTTAA","protein_sequence":"MFKRYLSSTSSRRFTSILEEKAFQVTTYSRPEDLCITRGKNAKLYDDVNGKEYIDFTAGIAVTALGHANPKVAEILHHQANKLVHSSNLYFTKECLDLSEKIVEKTKQFGGQHDASRVFLCNSGTEANEAALKFAKKHGIMKNPSKQGIVAFENSFHGRTMGALSVTWNSKYRTPFGDLVPHVSFLNLNDEMTKLQSYIETKKDEIAGLIVEPIQGEGGVFPVEVEKLTGLKKICQDNDVIVIHDEIQCGLGRSGKLWAHAYLPSEAHPDIFTSAKALGNGFPIAATIVNEKVNNALRVGDHGTTYGGNPLACSVSNYVLDTIADEAFLKQVSKKSDILQKRLREIQAKYPNQIKTIRGKGLMLGAEFVEPPTEVIKKARELGLLIITAGKSTVRFVPALTIEDELIEEGMDAFEKAIEAVYA"},{"created_at":"2011-05-26T16:34:45.000Z","updated_at":"2011-07-22T17:53:55.000Z","name":"Protein ARG5,6, mitochondrial","uniprot_id":"Q01217","uniprot_name":"ARG56_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG5","num_residues":863,"molecular_weight":"94868.39844","theoretical_pi":"8.45","general_function":"Involved in acetylglutamate kinase activity","specific_function":"N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH","reactions":[{"id":1244,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1752,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2427,"direction":"\u003e","locations":"Mitochondrion","altext":"N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2428,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"U18813","genbank_protein_id":"603305","gene_card_id":"ARG5","chromosome_location":null,"locus":"YER069W","synonyms":["N-acetyl-gamma-glutamyl-phosphate reductase","N-acetyl-glutamate semialdehyde dehydrogenase","NAGSA dehydrogenase","Acetylglutamate kinase","N-acetyl-L-glutamate 5-phosphotransferase","NAG kinase","AGK"],"enzyme_classes":["1.2.1.38","2.7.2.8"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" mitochondrion"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" protein dimerization activity"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" N-acetyl-gamma-glutamyl-phosphate reductase activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" acetylglutamate kinase activity"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" protein binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine biosynthetic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" arginine metabolic process"}],"pfams":[{"name":"Semialdhyde_dh","identifier":"PF01118"},{"name":"Semialdhyde_dhC","identifier":"PF02774"},{"name":"DUF619","identifier":"PF04768"},{"name":"AA_kinase","identifier":"PF00696"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGCCATCTGCTAGCTTACTCGTCTCGACAAAGAGACTTAACGCTTCCAAATTCCAAAAATTTGTGTCTTCATTAAACAAATCCACCATAGCAGGATTTGCATCTGTACCCTTGAGAGCTCCACCATCCGTTGCATTTACGAGAAAGAAAGTCGGATACTCAAAGAGGTATGTTTCATCTACTAACGGCTTTTCAGCTACTAGATCCACTGTGATCCAACTGTTGAACAATATCAGCACAAAAAGAGAGGTTGAACAATATTTGAAATATTTCACTTCCGTCTCACAACAACAATTTGCTGTGATCAAGGTGGGTGGTGCCATTATCAGCGACAATCTACACGAACTCGCTTCCTGCTTGGCATTTTTGTATCATGTTGGTCTATATCCAATAGTTTTACATGGTACCGGTCCTCAGGTTAATGGAAGGCTAGAAGCGCAGGGAATTGAGCCAGACTATATTGATGGTATTAGAATCACGGATGAGCACACAATGGCCGTAGTTAGAAAATGTTTTTTGGAACAAAATCTTAAGCTAGTTACTGCATTAGAACAGCTAGGGGTCCGTGCAAGACCCATTACTTCTGGTGTTTTTACTGCTGACTATTTGGATAAGGACAAATACAAGCTAGTGGGCAATATTAAAAGTGTCACAAAAGAGCCAATTGAAGCATCTATTAAGGCAGGTGCCCTACCAATCTTGACCTCTTTAGCCGAAACTGCTTCTGGTCAAATGTTGAACGTCAACGCCGACGTAGCTGCTGGTGAATTAGCCCGTGTTTTTGAGCCTTTGAAGATCGTTTACCTGAATGAGAAAGGGGGTATTATCAATGGCTCCACGGGAGAAAAAATTTCGATGATCAATTTGGATGAAGAGTATGACGATTTAATGAAGCAAAGTTGGGTGAAGTATGGTACCAAATTAAAAATTAGAGAAATTAAAGAGCTTTTGGACTATCTTCCTCGTTCTTCTTCAGTTGCAATCATTAACGTTCAAGATCTACAAAAAGAACTGTTCACTGATTCTGGTGCGGGTACTATGATCAGGAGAGGTTACAAATTAGTGAAGAGATCCTCCATTGGCGAATTTCCATCCGCTGATGCTCTAAGAAAAGCTCTTCAAAGGGACGCTGGCATTAGTTCCGGTAAAGAATCTGTTGCTTCTTATTTAAGATATTTGGAAAACTCTGATTTTGTCTCTTATGCTGATGAACCTCTTGAAGCAGTGGCCATTGTAAAGAAAGATACGAACGTTCCCACACTAGACAAATTTGTCTGTTCTGACGCAGCCTGGTTGAATAACGTCACAGATAATGTATTCAATGTTTTGCGCCGTGATTTTCCTGCTTTACAATGGGTAGTCAGTGAAAATGATGCTAACATTGCATGGCATTTTGATAAGTCTCAAGGTTCATATCTAAAAGGCGGAAAAGTTTTGTTCTGGTATGGTATCGATGATATAAATACAATATCCGAGCTCGTTGAAAATTTTGTGAAGTCGTGTGACACTGCTTCTACCCTCAACTCATCAGCAAGTAGTGGAGTATTTGCTAACAAAAAATCAGCTAGGTCGTACTCAACTAGATCCACTCCTCGTCCCGAGGGAGTTAACACCAACCCTGGTCGTGTCGCGCTTATTGGTGCTAGAGGTTACACAGGTAAAAATTTGGTATCTTTGATCAACGGCCACCCATATTTAGAAGTGGCCCATGTTTCTTCTCGTGAATTGAAAGGTCAAAAGTTGCAAGATTATACAAAATCCGAAATTATATATGAAAGTTTGCAAATACAGGATATTAGGAAACTGGAAGAACAAAATGCTGTGGACTTTTGGGTTATGGCATTACCCAACAAAGTCTGTGAACCTTTCGTTGAGACAATCCAAAGTGTTCATGGTAAGTCTAAAATTATTGATCTGTCCGCTGATCACAGGTTTGTATCAGAATCAGACTGGGCTTACGGTTTGCCAGAATTGAATGATAGAGCAAAAATTGCAAACGCTGCCAAAATTGCTAATCCCGGTTGTTATGCTACTGGTTCGCAATTAACTATTTCTCCGTTAACAAAGTATATCAATGGTCTTCCAACTGTGTTTGGTGTTTCAGGGTATTCAGGCGCGGGGACGAAGCCTTCTCCAAAAAACGATCCCAAATTCTTGAACAATAACTTAATTCCTTACGCTTTAAGTGATCATATACACGAACGCGAAATCTCAGCTCGCATTGGGCACAATGTTGCATTCATGCCCCATGTTGGGCAGTGGTTTCAAGGTATCTCTTTGACCGTCTCTATTCCAATAAAAAAAGGTTCCTTGTCTATTGATGAGATCAGGAAATTATACAGAAATTTTTACGAAGACGAAAAGCTAGTACATGTCATCGATGATATCCCACTGGTTAAAGATATTGAGGGCACCCATGGTGTAGTTATTGGTGGTTTCAAGCTGAATGATGCTGAAGATCGTGTAGTTGTTTGCGCAACCATCGATAACTTACTTAAAGGCGCCGCTACTCAATGTCTGCAAAATATTAATCTTGCTATGGGTTATGGAGAGTATGCTGGTATCCCTGAAAATAAAATTATTGGTGTCTGA","protein_sequence":"MPSASLLVSTKRLNASKFQKFVSSLNKSTIAGFASVPLRAPPSVAFTRKKVGYSKRYVSSTNGFSATRSTVIQLLNNISTKREVEQYLKYFTSVSQQQFAVIKVGGAIISDNLHELASCLAFLYHVGLYPIVLHGTGPQVNGRLEAQGIEPDYIDGIRITDEHTMAVVRKCFLEQNLKLVTALEQLGVRARPITSGVFTADYLDKDKYKLVGNIKSVTKEPIEASIKAGALPILTSLAETASGQMLNVNADVAAGELARVFEPLKIVYLNEKGGIINGSTGEKISMINLDEEYDDLMKQSWVKYGTKLKIREIKELLDYLPRSSSVAIINVQDLQKELFTDSGAGTMIRRGYKLVKRSSIGEFPSADALRKALQRDAGISSGKESVASYLRYLENSDFVSYADEPLEAVAIVKKDTNVPTLDKFVCSDAAWLNNVTDNVFNVLRRDFPALQWVVSENDANIAWHFDKSQGSYLKGGKVLFWYGIDDINTISELVENFVKSCDTASTLNSSASSGVFANKKSARSYSTRSTPRPEGVNTNPGRVALIGARGYTGKNLVSLINGHPYLEVAHVSSRELKGQKLQDYTKSEIIYESLQIQDIRKLEEQNAVDFWVMALPNKVCEPFVETIQSVHGKSKIIDLSADHRFVSESDWAYGLPELNDRAKIANAAKIANPGCYATGSQLTISPLTKYINGLPTVFGVSGYSGAGTKPSPKNDPKFLNNNLIPYALSDHIHEREISARIGHNVAFMPHVGQWFQGISLTVSIPIKKGSLSIDEIRKLYRNFYEDEKLVHVIDDIPLVKDIEGTHGVVIGGFKLNDAEDRVVVCATIDNLLKGAATQCLQNINLAMGYGEYAGIPENKIIGV"}]}