malonyl-CoA (YMDB00533)

General function:

Involved in fatty acid elongase activity

Specific function:

Involved in synthesis of 1,3-beta-glucan. Could be a subunit of 1,3-beta-glucan synthase. Could be also a component of the membrane bound fatty acid elongation systems that produce the 26-carbon very long chain fatty acids that are precursors for ceramide and sphingolipids. Appears to be involved in the elongation of fatty acids up to 24 carbons. Appears to have the highest affinity for substrates with chain length less than 22 carbons

Gene Name:

FEN1

Uniprot ID:

P25358

Molecular weight:

40001.80078

Reactions

General function:

Involved in fatty acid elongase activity

Specific function:

May be a membrane bound enzyme involved in the highly specific elongation of saturated 14-carbon fatty acids (14:0) to 16-carbon species (16:0)

Gene Name:

ELO1

Uniprot ID:

P39540

Molecular weight:

36233.60156

Reactions

General function:

Involved in acyl carrier activity

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Gene Name:

ACP1

Uniprot ID:

P32463

Molecular weight:

13942.5

General function:

Involved in transferase activity

Specific function:

Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for:[acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase

Gene Name:

FAS1

Uniprot ID:

P07149

Molecular weight:

228689.0

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for:acyl carrier protein, 3- oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl- carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex

Gene Name:

FAS2

Uniprot ID:

P19097

Molecular weight:

206945.0

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway. Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid. This protein carries three functions:biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase

Gene Name:

HFA1

Uniprot ID:

P32874

Molecular weight:

259161.0

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase

Gene Name:

FAS3

Uniprot ID:

Q00955

Molecular weight:

250351.0

Reactions

General function:

Involved in transferase activity

Specific function:

Involved in biosynthesis of fatty acids in mitochondria

Gene Name:

MCT1

Uniprot ID:

Q12283

Molecular weight:

40706.89844

Reactions