{"ymdb_id":"YMDB00533","created_at":"2011-05-29T18:27:59.000Z","updated_at":"2016-09-08T18:35:35.000Z","name":"malonyl-CoA","cas":"524-14-1","state":"Solid","melting_point":"","description":"Malonyl-CoA is a coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. Fatty acids must be activated with CoA before any chemical modification can be applied. Also fatty acid metabolic intermediates will also exists as CoA derivatives until the CoA is enzymatically cleaved. The fatty acid group is linked to the terminal thoil moiety of CoA.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"mitochondrion;lipid particle;endoplasmic reticulum;cytoplasm","synthesis_reference":"Hulsmann, W. C.  Synthesis of malonyl coenzyme A from acetyl coenzyme A and oxalosuccinate in mitochondria.    Biochimica et Biophysica Acta  (1963),  77(3),  502-3. ","chebi_id":"15531","hmdb_id":"HMDB01175","kegg_id":"C00083","pubchem_id":"10663","cs_id":"24785730","foodb_id":null,"wikipedia_link":"Malonyl-CoA","biocyc_id":"MALONYL-COA","iupac":"3-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-3-oxopropanoic acid","traditional_iupac":"malonyl-coa","logp":"-5.989775961268886","pka":"1.894671247515889","alogps_solubility":"3.80e+00 g/l","alogps_logp":"-0.62","alogps_logs":"-2.35","acceptor_count":"19","donor_count":"10","rotatable_bond_count":"22","polar_surface_area":"400.9299999999999","refractivity":"178.55210000000002","polarizability":"75.32782020538158","formal_charge":"0","physiological_charge":"-5","pka_strongest_basic":"4.198301701266371","pka_strongest_acidic":"0.820480609980446","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["Malonyl CoA","Malonyl Coenzyme A","malonyl-CoA","malonyl-Coenzyme A","omega-Carboxyacyl-CoA","omega-Carboxyacyl-Coenzyme A","S-(Hydrogen malonyl)coenzyme A","S-(hydrogen propanedioate","S-(hydrogen propanedioate) CoA","S-(hydrogen propanedioate) Coenzyme A","S-(hydrogen propanedioic acid"],"pathways":[{"name":"Fatty acid biosynthesis","kegg_map_id":"00061"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"},{"name":"Biosynthesis of unsaturated fatty acids (docosanoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (icosanoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (stearoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (tetracosanoyl-CoA)","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":16730802,"citation":"Dickson, R. C., Sumanasekera, C., Lester, R. L. (2006). \"Functions and metabolism of sphingolipids in Saccharomyces cerevisiae.\" Prog Lipid Res 45:447-465."},{"pubmed_id":14761959,"citation":"Hoja, U., Marthol, S., Hofmann, J., Stegner, S., Schulz, R., Meier, S., Greiner, E., Schweizer, E. (2004). \"HFA1 encoding an organelle-specific acetyl-CoA carboxylase controls mitochondrial fatty acid synthesis in Saccharomyces cerevisiae.\" J Biol Chem 279:21779-21786."},{"pubmed_id":11113186,"citation":"Kohlwein, S. D., Eder, S., Oh, C. S., Martin, C. E., Gable, K., Bacikova, D., Dunn, T. (2001). \"Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae.\" Mol Cell Biol 21:109-125."},{"pubmed_id":10850979,"citation":"Schneiter, R., Tatzer, V., Gogg, G., Leitner, E., Kohlwein, S. D. (2000). \"Elo1p-dependent carboxy-terminal elongation of C14:1Delta(9) to C16:1Delta(11) fatty acids in Saccharomyces cerevisiae.\" J Bacteriol 182:3655-3660."},{"pubmed_id":15387819,"citation":"Kastaniotis, A. J., Autio, K. J., Sormunen, R. T., Hiltunen, J. K. (2004). \"Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology.\" Mol Microbiol 53:1407-1421."}],"proteins":[{"created_at":"2011-05-24T21:24:38.000Z","updated_at":"2011-05-29T05:06:16.000Z","name":"Elongation of fatty acids protein 2","uniprot_id":"P25358","uniprot_name":"ELO2_YEAST","enzyme":true,"transporter":false,"gene_name":"FEN1","num_residues":347,"molecular_weight":"40001.80078","theoretical_pi":"9.83","general_function":"Involved in fatty acid elongase activity","specific_function":"Involved in synthesis of 1,3-beta-glucan. Could be a subunit of 1,3-beta-glucan synthase. Could be also a component of the membrane bound fatty acid elongation systems that produce the 26-carbon very long chain fatty acids that are precursors for ceramide and sphingolipids. Appears to be involved in the elongation of fatty acids up to 24 carbons. Appears to have the highest affinity for substrates with chain length less than 22 carbons","reactions":[{"id":2385,"direction":"\u003e","locations":"Membrane; Multi-pass membrane protein (Potential); Multi-pass membrane protein; Multi-pass membrane protein (Probable)","altext":"Acyl-CoA + malonyl-CoA = 3-oxoacyl-CoA + CoA + CO(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"63-83;108-128;201-221;245-265;276-296","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AF012655","genbank_protein_id":"2654761","gene_card_id":"FEN1","chromosome_location":"chromosome 3","locus":"YCR034W","synonyms":["Protein GNS1","v-SNARE bypass mutant gene 2 protein"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ELO","identifier":"PF01151"}],"pathways":[],"gene_sequence":"ATGAATTCACTCGTTACTCAATATGCTGCTCCGTTGTTCGAGCGTTATCCCCAACTTCATGACTATTTACCAACTTTGGAGCGACCATTTTTTAATATTTCGTTGTGGGAACATTTCGATGATGTCGTCACTCGTGTAACTAACGGTAGATTTGTTCCAAGCGAATTCCAATTCATTGCAGGTGAATTACCATTAAGCACTTTGCCCCCTGTGCTATACGCCATCACTGCCTATTACGTTATTATTTTTGGTGGCAGGTTTTTGTTAAGTAAGTCGAAACCATTTAAATTAAATGGCCTTTTCCAATTGCATAATTTGGTTTTAACTTCACTTTCATTGACGCTTTTATTGCTTATGGTTGAACAATTAGTGCCAATTATTGTTCAGCACGGGTTATACTTCGCTATCTGTAATATTGGTGCTTGGACTCAACCGCTCGTTACATTATATTACATGAATTACATTGTCAAGTTTATTGAATTTATAGACACCTTTTTCTTGGTGCTAAAACATAAAAAATTGACATTTTTGCATACTTATCACCATGGCGCTACTGCCTTATTATGTTACACCCAATTGATGGGCACCACATCTATTTCTTGGGTCCCTATTTCATTGAACCTTGGTGTTCACGTGGTTATGTATTGGTACTATTTCTTGGCTGCCAGAGGCATCAGGGTCTGGTGGAAGGAATGGGTTACCAGATTTCAAATTATCCAATTTGTTTTGGATATCGGTTTCATATATTTTGCTGTCTACCAAAAAGCAGTTCACTTGTATTTCCCAATTTTGCCACATTGTGGTGACTGTGTGGGTTCAACAACTGCCACCTTTGCAGGTTGTGCCATTATTTCTTCATATTTGGTACTATTTATTTCATTTTACATTAACGTTTATAAACGTAAAGGCACCAAAACCAGTAGAGTGGTAAAGCGTGCCCACGGCGGTGTTGCCGCAAAGGTTAATGAGTATGTTAACGTTGACTTGAAAAACGTTCCTACTCCATCTCCATCACCAAAACCTCAACACAGAAGAAAAAGGTAA","protein_sequence":"MNSLVTQYAAPLFERYPQLHDYLPTLERPFFNISLWEHFDDVVTRVTNGRFVPSEFQFIAGELPLSTLPPVLYAITAYYVIIFGGRFLLSKSKPFKLNGLFQLHNLVLTSLSLTLLLLMVEQLVPIIVQHGLYFAICNIGAWTQPLVTLYYMNYIVKFIEFIDTFFLVLKHKKLTFLHTYHHGATALLCYTQLMGTTSISWVPISLNLGVHVVMYWYYFLAARGIRVWWKEWVTRFQIIQFVLDIGFIYFAVYQKAVHLYFPILPHCGDCVGSTTATFAGCAIISSYLVLFISFYINVYKRKGTKTSRVVKRAHGGVAAKVNEYVNVDLKNVPTPSPSPKPQHRRKR"},{"created_at":"2011-05-24T21:48:56.000Z","updated_at":"2011-07-22T17:54:52.000Z","name":"Elongation of fatty acids protein 1","uniprot_id":"P39540","uniprot_name":"ELO1_YEAST","enzyme":true,"transporter":false,"gene_name":"ELO1","num_residues":310,"molecular_weight":"36233.60156","theoretical_pi":"9.69","general_function":"Involved in fatty acid elongase activity","specific_function":"May be a membrane bound enzyme involved in the highly specific elongation of saturated 14-carbon fatty acids (14:0) to 16-carbon species (16:0)","reactions":[{"id":1499,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1501,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1503,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2385,"direction":"\u003e","locations":"Membrane; Multi-pass membrane protein (Potential); Multi-pass membrane protein; Multi-pass membrane protein (Probable)","altext":"Acyl-CoA + malonyl-CoA = 3-oxoacyl-CoA + CoA + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3865,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006386","source":"Smpdb"},{"id":3866,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006396","source":"Smpdb"},{"id":3867,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006400","source":"Smpdb"},{"id":3868,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006392","source":"Smpdb"},{"id":3869,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006404","source":"Smpdb"},{"id":3870,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006412","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"64-84;101-121;187-207;235-255;272-292","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"X77688","genbank_protein_id":"547599","gene_card_id":"ELO1","chromosome_location":"chromosome 10","locus":"YJL196C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ELO","identifier":"PF01151"}],"pathways":[{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"}],"gene_sequence":"ATGGTAAGTGATTGGAAAAATTTTTGCCTCGAGAAAGCCTCTAGGTTTCGCCCAACAATAGATAGGCCTTTTTTTAATATTTATTTGTGGGACTATTTCAATCGTGCGGTTGGGTGGGCCACTGCAGGTCGCTTCCAGCCAAAGGATTTTGAGTTTACCGTTGGGAAGCAGCCTTTGAGTGAACCTCGTCCGGTACTGCTTTTTATTGCCATGTATTATGTGGTTATATTTGGCGGGAGGTCCCTGGTAAAGTCATGTAAACCTCTCAAGTTGAGATTTATTTCTCAAGTCCATAACTTGATGTTGACTTCTGTTTCCTTTTTATGGTTGATTTTGATGGTGGAACAGATGCTACCCATAGTGTATCGCCATGGGCTGTATTTTGCTGTTTGTAATGTTGAATCGTGGACGCAACCGATGGAGACATTATATTATCTCAACTATATGACAAAGTTTGTGGAGTTCGCAGACACTGTCTTGATGGTGTTGAAACATAGAAAGTTGACTTTCCTACATACATACCATCATGGTGCTACAGCTTTACTGTGCTATAATCAATTGGTTGGTTACACAGCAGTTACATGGGTTCCTGTCACCTTAAACTTAGCTGTTCACGTTCTTATGTATTGGTATTATTTCCTTTCTGCTAGCGGAATTCGTGTTTGGTGGAAAGCCTGGGTTACAAGACTACAAATTGTGCAGTTCATGCTTGATCTCATTGTCGTTTATTACGTGCTTTATCAGAAGATTGTTGCTGCATATTTCAAAAATGCTTGTACTCCACAGTGTGAGGATTGCTTAGGTTCAATGACGGCTATTGCTGCTGGTGCAGCCATTCTTACATCCTACTTGTTTTTGTTCATCTCTTTCTATATTGAGGTTTACAAACGTGGAAGTGCTAGTGGTAAGAAGAAGATCAACAAAAACAATTAA","protein_sequence":"MVSDWKNFCLEKASRFRPTIDRPFFNIYLWDYFNRAVGWATAGRFQPKDFEFTVGKQPLSEPRPVLLFIAMYYVVIFGGRSLVKSCKPLKLRFISQVHNLMLTSVSFLWLILMVEQMLPIVYRHGLYFAVCNVESWTQPMETLYYLNYMTKFVEFADTVLMVLKHRKLTFLHTYHHGATALLCYNQLVGYTAVTWVPVTLNLAVHVLMYWYYFLSASGIRVWWKAWVTRLQIVQFMLDLIVVYYVLYQKIVAAYFKNACTPQCEDCLGSMTAIAAGAAILTSYLFLFISFYIEVYKRGSASGKKKINKNN"},{"created_at":"2011-05-24T21:51:21.000Z","updated_at":"2011-05-29T05:06:17.000Z","name":"Acyl carrier protein, mitochondrial","uniprot_id":"P32463","uniprot_name":"ACPM_YEAST","enzyme":true,"transporter":false,"gene_name":"ACP1","num_residues":125,"molecular_weight":"13942.5","theoretical_pi":"4.57","general_function":"Involved in acyl carrier activity","specific_function":"Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain","reactions":[],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY558392","genbank_protein_id":"45270674","gene_card_id":"ACP1","chromosome_location":"chromosome 11","locus":"YKL192C","synonyms":["ACP","NADH-ubiquinone oxidoreductase 9.6 kDa subunit"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" phosphopantetheine binding"},{"category":"Function","description":" substrate-specific transporter activity"},{"category":"Function","description":" acyl carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" carboxylic acid binding"},{"category":"Function","description":" amino acid binding"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" cofactor binding"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"}],"pfams":[{"name":"PP-binding","identifier":"PF00550"}],"pathways":[],"gene_sequence":"ATGTTTAGATCCGTTTGCCGCATTTCTTCCCGCGTGGCACCTTCTGCGTACCGCACTATAATGGGCCGTTCCGTTATGTCCAACACCATACTCGCACAAAGATTTTATTCTGCAAACTTGAGCAAAGATCAGGTTTCTCAAAGGGTCATTGATGTTATCAAGGCGTTTGATAAGAACTCTCCCAACATTGCCAACAAGCAAATCTCCAGCGATACCCAATTTCACAAGGATTTGGGGTTGGACTCCTTGGACACTGTCGAGCTGCTCGTAGCTATTGAAGAAGAATTTGATATTGAAATCCCTGACAAAGTGGCTGATGAGTTGAGAAGTGTTGGTGAAACGGTCGATTATATCGCTTCCAATCCCGACGCAAACTAA","protein_sequence":"MFRSVCRISSRVAPSAYRTIMGRSVMSNTILAQRFYSANLSKDQVSQRVIDVIKAFDKNSPNIANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIASNPDAN"},{"created_at":"2011-05-26T16:04:15.000Z","updated_at":"2011-05-27T15:00:59.000Z","name":"Fatty acid synthase subunit beta","uniprot_id":"P07149","uniprot_name":"FAS1_YEAST","enzyme":true,"transporter":false,"gene_name":"FAS1","num_residues":2051,"molecular_weight":"228689.0","theoretical_pi":"5.73","general_function":"Involved in transferase activity","specific_function":"Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for:[acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase","reactions":[{"id":2400,"direction":"\u003e","locations":"","altext":"Acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH = long-chain-acyl-CoA + n CoA + n CO(2) + 2n NAD(+) + 2n NADP(+).","export":false,"pw_reaction_id":null,"source":null},{"id":2401,"direction":"\u003e","locations":null,"altext":"Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].","export":false,"pw_reaction_id":null,"source":null},{"id":2402,"direction":"\u003e","locations":"Mitochondrion","altext":"Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].","export":false,"pw_reaction_id":null,"source":null},{"id":2403,"direction":"\u003e","locations":null,"altext":"(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] = hexadec-2-enoyl-[acyl-carrier-protein] + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":2404,"direction":"\u003e","locations":null,"altext":"Acyl-[acyl-carrier-protein] + NAD(+) = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":2405,"direction":"\u003e","locations":null,"altext":"Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M30162","genbank_protein_id":"171500","gene_card_id":"FAS1","chromosome_location":"chromosome 11","locus":"YKL182W","synonyms":["3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase","Enoyl-[acyl-carrier-protein] reductase [NADH]","[Acyl-carrier-protein] acetyltransferase","[Acyl-carrier-protein] malonyltransferase","S-acyl fatty acid synthase thioesterase"],"enzyme_classes":["2.3.1.86","4.2.1.61","1.3.1.9","2.3.1.38","2.3.1.39","3.1.2.14"],"go_classes":[{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Component","description":" fatty acid synthase complex"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" fatty acid synthase activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"}],"pfams":[{"name":"Acyl_transf_1","identifier":"PF00698"},{"name":"DUF1729","identifier":"PF08354"},{"name":"MaoC_dehydratas","identifier":"PF01575"}],"pathways":[{"name":"Fatty acid biosynthesis","kegg_map_id":"00061"}],"gene_sequence":"ATGGACGCTTACTCCACAAGACCATTAACCCTATCTCACGGTTCTTTAGAGCACGTGCTTCTGGTACCAACCGCTTCATTTTTCATTGCTTCGCAATTACAAGAACAATTTAATAAAATTTTGCCCGAACCCACTGAAGGGTTTGCTGCAGATGACGAGCCTACCACACCTGCTGAACTAGTGGGGAAATTCCTTGGCTACGTATCTTCTCTAGTCGAACCTTCCAAGGTCGGTCAATTCGATCAGGTCTTGAACCTTTGCTTAACAGAATTTGAAAACTGTTATTTAGAAGGCAATGACATTCACGCCTTGGCTGCTAAACTATTACAGGAAAACGACACAACTTTAGTGAAGACTAAAGAACTAATTAAAAATTATATTACCGCCAGAATAATGGCTAAGAGACCATTTGACAAAAAATCCAACTCTGCTCTTTTTAGGGCCGTCGGCGAGGGTAACGCACAATTGGTAGCCATTTTCGGTGGTCAAGGTAACACCGACGACTACTTTGAAGAATTGCGTGATCTATATCAAACTTATCATGTCTTAGTGGGAGATTTAATCAAGTTCTTCGCTGAAACTTTAAGTGAACTGATTAGAACTACTTTAGATGCTGAAAAAGTCTTTACTCAAGGTTTAAACATATTGGAATGGTTGGAGAACCCTTCAAATACCCCAGACAAGGACTATTTACTTTCCATTCCAATTTCATGCCCCTTAATTGGTGTCATTCAATTGGCTCACTACGTAGTTACTGCCAAGCTTTTGGGTTTCACTCCAGGTGAGTTAAGATCTTACTTAAAAGGTGCTACAGGTCACTCTCAAGGTTTGGTTACTGCTGTCGCCATAGCTGAGACGGATTCCTGGGAATCCTTCTTCGTCTCCGTAAGAAAAGCAATTACTGTATTATTCTTCATCGGTGTTCGTTGTTACGAAGCATACCCAAACACTTCCCTACCACCATCCATCTTGGAAGATTCCTTGGAAAACAATGAAGGTGTTCCATCTCCAATGTTGTCCATTTCCAATCTAACTCAAGAACAAGTTCAAGACTATGTAAATAAGACTAACTCTCATTTGCCAGCTGGTAAACAAGTTGAAATTTCTCTAGTCAATGGTGCGAAGAATCTAGTCGTATCGGGCCCACCACAATCATTATATGGTTTAAACTTGACTTTAAGAAAGGCCAAGGCCCCATCTGGACTGGATCAATCAAGAATCCCATTCAGCGAAAGAAAATTGAAGTTCTCCAATAGGTTCTTACCTGTTGCATCACCATTCCATTCCCATCTATTGGTTCCAGCTTCAGATTTGATTAACAAAGACTTAGTCAAAAACAATGTCAGCTTTAACGCTAAAGATATTCAAATCCCCGTTTACGACACTTTTGATGGTTCAGATCTAAGAGTCCTTTCAGGTTCCATTTCCGAGAGAATCGTCGACTGCATCATTAGATTACCTGTCAAATGGGAAACTACTACACAATTCAAAGCCACCCACATATTAGACTTTGGTCCAGGTGGAGCTTCCGGTTTAGGTGTTTTAACCCATCGTAATAAAGATGGTACTGGTGTTCGTGTTATCGTTGCCGGTACTCTCGACATTAACCCAGATGATGATTACGGATTCAAGCAAGAAATCTTTGATGTTACTAGTAATGGTTTGAAGAAAAATCCAAACTGGTTGGAAGAATACCATCCAAAATTAATTAAGAACAAATCAGGCAAAATTTTTGTCGAAACAAAATTTTCTAAATTAATCGGTAGACCACCTTTATTGGTTCCTGGTATGACACCATGTACTGTTTCTCCAGATTTCGTAGCTGCTACCACAAATGCTGGTTATACCATTGAGTTGGCCGGTGGTGGTTACTTTTCCGCAGCAGGTATGACCGCCGCTATTGATTCTGTGGTTTCTCAGATAGAAAAGGGTAGTACCTTCGGTATCAACTTGATCTACGTCAATCCATTTATGTTACAATGGGGTATTCCATTAATCAAGGAACTAAGAAGCAAAGGTTATCCAATTCAATTCTTGACCATTGGTGCTGGTGTCCCATCATTGGAAGTTGCTAGTGAATACATAGAGACATTAGGTTTGAAGTACTTGGGTTTGAAACCAGGTTCCATTGATGCTATTTCGCAAGTTATAAACATTGCTAAAGCACATCCAAACTTCCCAATAGCTTTACAATGGACCGGTGGTAGAGGTGGTGGTCATCATTCTTTCGAAGATGCCCACACTCCAATGTTACAAATGTACTCCAAGATTAGAAGACATCCAAACATTATGTTGATATTCGGTTCTGGTTTCGGTTCTGCTGATGACACTTACCCATACTTAACCGGTGAATGGTCCACAAAATTCGATTATCCACCAATGCCATTCGATGGTTTCCTATTTGGTTCGAGGGTCATGATTGCTAAGGAAGTTAAAACTTCTCCTGATGCTAAGAAGTGTATTGCTGCTTGTACTGGTGTTCCTGATGATAAATGGGAACAAACCTACAAGAAGCCAACTGGTGGTATTGTCACTGTTCGCTCTGAAATGGGTGAACCAATTCACAAAATTGCCACTCGTGGTGTTATGCTATGGAAGGAATTCGACGAAACCATCTTCAACTTACCAAAGAATAAGTTGGTACCAACTTTGGAAGCAAAGAGAGATTACATTATCTCAAGATTGAACGCCGATTTCCAAAAACCATGGTTTGCTACCGTCAACGGTCAAGCCCGTGACCTAGCCACAATGACATACGAAGAAGTTGCAAAGAGATTGGTGGAATTAATGTTCATCAGATCTACCAACTCTTGGTTTGATGTCACATGGAGAACCTTTACTGGTGATTTCCTACGTCGTGTCGAAGAACGTTTCACTAAAAGTAAGACATTGTCTTTAATCCAATCCTATTCTCTACTAGACAAGCCTGATGAAGCTATTGAAAAAGTATTTAATGCTTATCCTGCCGCTAGGGAACAGTTCTTGAATGCGCAAGATATTGATCACTTTTTGAGCATGTGTCAAAATCCAATGCAAAAACCAGTGCCTTTTGTTCCAGTTTTGGATCGTAGATTCGAGATTTTTTTCAAAAAAGATTCGTTATGGCAATCTGAGCAATTGGAAGCCGTCGTCGACCAAGACGTTCAAAGAACATGTATCCTACATGGACCTGTTGCAGCACAATTCACTAAAGTCATCGATGAACCAATTAAGAGCATTATGGATGGTATTCACGATGGTCACATCAAAAAGTTACTACATCAATATTACGGTGACGATGAGTCAAAGATTCCAGCAGTTGAGTACTTTGGTGGTGAAAGCCCTGTAGACGTACAAAGTCAAGTTGATTCTTCCTCTGTATCTGAAGACTCAGCTGTTTTTAAGGCAACATCCTCTACTGATGAAGAAAGCTGGTTTAAGGCTTTGGCGGGATCCGAAATTAACTGGAGACATGCAAGTTTCTTATGTTCCTTTATCACTCAAGATAAAATGTTTGTTTCTAACCCAATTAGAAAAGTTTTCAAGCCAAGCCAAGGAATGGTTGTTGAGTTTTCCAACGGCAATACTTCTTCAAAGACTGTTGTCACTCTTTCAGAACCTGTTCAAGGTGAATTGAAACCAACTGTTATTTTGAAGTTGTTGAAGGAGAACATAATCCAAATGGAAATGATTGAGAACAGAACTATGGATGGTAAGCCCGTCAGCTTGCCATTGTTGTACAACTTCAACCCAGATAATGGTTTTGCTCCAATCTCTGAAGTTATGGAGGACAGAAACCAAAGAATTAAGGAAATGTACTGGAAATTATGGATTGATGAGCCTTTCAATTTGGACTTTGACCCAAGAGATGTCATTAAGGGCAAAGATTTCGAGATCACCGCTAAAGAAGTTTATGACTTTACACACGCTGTTGGAAACAATTGTGAAGACTTCGTTTCTAGACCTGATAGAACGATGTTGGCCCCAATGGACTTTGCTATTGTTGTCGGATTGAGAGGCATCATCAAGGCCATTTTCCCTAATACGGTCGATGGTGACTTATTGAAGTTGGTTCATTTGTCTAACGGCTACAAGATGATTCCTGGCGCTAAGCCACTGCAAGTTGGTGATGTTGTTTCAACTACTGCTGTTATTGAATCTGTCGTCAACCAACCTACAGGAAAGATTGTCGATGTGGTAGGTACATTATCGAGAAATGGCAAGCCTGTCATGGAAGTCACCTCCTCATTCTTCTACAGAGGCAACTATACTGACTTTGAAAACACTTTCCAAAAGACTGTTGAACCTGTTTATCAAATGCACATCAAAACTTCTAAAGATATAGCTGTCTTGCGCTCTAAGGAGTGGTTCCAATTGGACGATGAAGACTTCGATCTGTTAAACAAAACTTTGACTTTCGAAACTGAAACTGAAGTTACTTTCAAGAATGCTAACATCTTCTCTTCAGTGAAATGTTTTGGCCCAATTAAAGTTGAATTGCCAACCAAAGAAACCGTGGAGATCGGTATTGTCGATTACGAAGCCGGTGCCTCTCACGGTAACCCTGTTGTTGATTTCTTGAAGAGAAACGGTTCCACATTGGAACAAAAGGTCAATCTAGAAAATCCTATTCCAATTGCAGTACTTGATTCGTACACTCCAAGTACCAACGAACCATACGCTAGAGTTTCTGGTCATTTGAATCCAATTCACGTTTCACGTCATTTTGCCTCTTACGCAAACTTGCCAGGTACTATCACGCACGGTATGTTTTCTTCTGCTTCCGTCCGTGCTTTGATTGAAAACTGGGCTGCTGACAGTGTTTCATCCAGGGTACGTGGCTACACTTGTCAATTTGTTGACATGGTTTTGCCTAACACTGCTTTGAAAACATCGATTCAACATGTTGGTATGATCAATGGTAGAAAATTGATAAAGTTTGAAACTAGAAATGAAGATGACGTTGTAGTTTTGACTGGTGAAGCCGAAATTGAACAACCTGGTACTACCTTCGTTTTCACTGGTCAAGGTTCACAAGAACAAGGTATGGGTATGGACTTATACAAAACTTCTAAAGCTGCTCAAGATGTTTGGAATAGAGCTGACAACCATTTCAAGGACACTTATGGTTTCTCTATCTTAGACATTGTCATTAACAACCCAGTTAACTTAACAATTCACTTCGGTGGTGAAAAGGGTAAGAGGATCAGAGAAAACTATTCTGCTATGATCTTTGAGACTATCGTGGATGGAAAATTGAAGACTGAAAAAATTTTCAAGGAAATTAATGAGCACAGTACTTCTTACACATTTAGATCTGAAAAAGGTTTATTGTCTGCTACTCAATTTACACAACCAGCTTTAACTTTGATGGAAAAAGCTGCTTTCGAAGACTTGAAATCTAAAGGTTTGATCCCAGCCGATGCTACTTTTGCTGGTCACTCTTTAGGTGAGTATGCTGCTTTGGCCTCTTTGGCTGATGTTATGTCTATCGAATCTTTAGTTGAAGTTGTGTTCTACAGAGGTATGACTATGCAAGTTGCTGTTCCAAGAGATGAGTTGGGCAGATCCAACTATGGTATGATTGCCATTAACCCAGGTAGAGTCGCTGCATCATTCTCTCAAGAAGCTTTGCAATATGTTGTTGAGAGAGTTGGTAAGAGAACCGGCTGGTTGGTTGAAATCGTCAACTACAACGTTGAAAACCAACAATATGTTGCAGCTGGTGATCTAAGAGCTTTAGACACCGTTACCAATGTTCTAAACTTCATCAAATTACAAAAAATTGATATTATTGAACTACAAAAGTCCTTATCTTTGGAAGAAGTTGAAGGTCATTTGTTTGAGATCATTGACGAAGCTTCCAAGAAATCTGCTGTCAAGCCTCGCCCACTTAAATTGGAGAGAGGTTTTGCTTGTATCCCATTAGTTGGTATTTCTGTTCCTTTCCATTCCACCTACTTGATGAATGGTGTTAAACCATTCAAGAGTTTCTTGAAGAAGAATATCATAAAAGAAAATGTGAAGGTTGCTAGATTGGCCGGAAAGTACATTCCAAACTTGACTGCAAAACCATTCCAGGTTACTAAGGAATATTTCCAGGACGTTTATGATTTGACTGGCTCCGAACCTATCAAGGAAATCATCGACAACTGGGAAAAGTATGAACAATCCTAA","protein_sequence":"MDAYSTRPLTLSHGSLEHVLLVPTASFFIASQLQEQFNKILPEPTEGFAADDEPTTPAELVGKFLGYVSSLVEPSKVGQFDQVLNLCLTEFENCYLEGNDIHALAAKLLQENDTTLVKTKELIKNYITARIMAKRPFDKKSNSALFRAVGEGNAQLVAIFGGQGNTDDYFEELRDLYQTYHVLVGDLIKFSAETLSELIRTTLDAEKVFTQGLNILEWLENPSNTPDKDYLLSIPISCPLIGVIQLAHYVVTAKLLGFTPGELRSYLKGATGHSQGLVTAVAIAETDSWESFFVSVRKAITVLFFIGVRCYEAYPNTSLPPSILEDSLENNEGVPSPMLSISNLTQEQVQDYVNKTNSHLPAGKQVEISLVNGAKNLVVSGPPQSLYGLNLTLRKAKAPSGLDQSRIPFSERKLKFSNRFLPVASPFHSHLLVPASDLINKDLVKNNVSFNAKDIQIPVYDTFDGSDLRVLSGSISERIVDCIIRLPVKWETTTQFKATHILDFGPGGASGLGVLTHRNKDGTGVRVIVAGTLDINPDDDYGFKQEIFDVTSNGLKKNPNWLEEYHPKLIKNKSGKIFVETKFSKLIGRPPLLVPGMTPCTVSPDFVAATTNAGYTIELAGGGYFSAAGMTAAIDSVVSQIEKGSTFGINLIYVNPFMLQWGIPLIKELRSKGYPIQFLTIGAGVPSLEVASEYIETLGLKYLGLKPGSIDAISQVINIAKAHPNFPIALQWTGGRGGGHHSFEDAHTPMLQMYSKIRRHPNIMLIFGSGFGSADDTYPYLTGEWSTKFDYPPMPFDGFLFGSRVMIAKEVKTSPDAKKCIAACTGVPDDKWEQTYKKPTGGIVTVRSEMGEPIHKIATRGVMLWKEFDETIFNLPKNKLVPTLEAKRDYIISRLNADFQKPWFATVNGQARDLATMTYEEVAKRLVELMFIRSTNSWFDVTWRTFTGDFLRRVEERFTKSKTLSLIQSYSLLDKPDEAIEKVFNAYPAAREQFLNAQDIDHFLSMCQNPMQKPVPFVPVLDRRFEIFFKKDSLWQSEHLEAVVDQDVQRTCILHGPVAAQFTKVIDEPIKSIMDGIHDGHIKKLLHQYYGDDESKIPAVEYFGGESPVDVQSQVDSSSVSEDSAVFKATSSTDEESWFKALAGSEINWRHASFLCSFITQDKMFVSNPIRKVFKPSQGMVVEISNGNTSSKTVVTLSEPVQGELKPTVILKLLKENIIQMEMIENRTMDGKPVSLPLLYNFNPDNGFAPISEVMEDRNQRIKEMYWKLWIDEPFNLDFDPRDVIKGKDFEITAKEVYDFTHAVGNNCEDFVSRPDRTMLAPMDFAIVVGWRAIIKAIFPNTVDGDLLKLVHLSNGYKMIPGAKPLQVGDVVSTTAVIESVVNQPTGKIVDVVGTLSRNGKPVMEVTSSFFYRGNYTDFENTFQKTVEPVYQMHIKTSKDIAVLRSKEWFQLDDEDFDLLNKTLTFETETEVTFKNANIFSSVKCFGPIKVELPTKETVEIGIVDYEAGASHGNPVVDFLKRNGSTLEQKVNLENPIPIAVLDSYTPSTNEPYARVSGDLNPIHVSRHFASYANLPGTITHGMFSSASVRALIENWAADSVSSRVRGYTCQFVDMVLPNTALKTSIQHVGMINGRKLIKFETRNEDDVVVLTGEAEIEQPVTTFVFTGQGSQEQGMGMDLYKTSKAAQDVWNRADNHFKDTYGFSILDIVINNPVNLTIHFGGEKGKRIRENYSAMIFETIVDGKLKTEKIFKEINEHSTSYTFRSEKGLLSATQFTQPALTLMEKAAFEDLKSKGLIPADATFAGHSLGEYAALASLADVMSIESLVEVVFYRGMTMQVAVPRDELGRSNYGMIAINPGRVAASFSQEALQYVVERVGKRTGWLVEIVNYNVENQQYVAAGDLRALDTVTNVLNFIKLQKIDIIELQKSLSLEEVEGHLFEIIDEASKKSAVKPRPLKLERGFACIPLVGISVPFHSTYLMNGVKPFKSFLKKNIIKENVKVARLAGKYIPNLTAKPFQVTKEYFQDVYDLTGSEPIKEIIDNWEKYEQS"},{"created_at":"2011-05-26T16:05:21.000Z","updated_at":"2011-05-27T15:00:59.000Z","name":"Fatty acid synthase subunit alpha","uniprot_id":"P19097","uniprot_name":"FAS2_YEAST","enzyme":true,"transporter":false,"gene_name":"FAS2","num_residues":1887,"molecular_weight":"206945.0","theoretical_pi":"5.11","general_function":"Involved in magnesium ion binding","specific_function":"Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for:acyl carrier protein, 3- oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl- carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex","reactions":[{"id":2400,"direction":"\u003e","locations":"","altext":"Acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH = long-chain-acyl-CoA + n CoA + n CO(2) + 2n NAD(+) + 2n NADP(+).","export":false,"pw_reaction_id":null,"source":null},{"id":2406,"direction":"\u003e","locations":"Mitochondrion (Potential)","altext":"Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].","export":false,"pw_reaction_id":null,"source":null},{"id":2407,"direction":"\u003e","locations":"Mitochondrion","altext":"(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X76890","genbank_protein_id":"854531","gene_card_id":"FAS2","chromosome_location":"chromosome 16","locus":"YPL231W","synonyms":["Acyl carrier","3-oxoacyl-[acyl-carrier-protein] reductase","Beta-ketoacyl reductase","3-oxoacyl-[acyl-carrier-protein] synthase","Beta-ketoacyl synthase"],"enzyme_classes":["2.3.1.86","1.1.1.100","2.3.1.41"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, for other substituted phosphate groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" holo-[acyl-carrier-protein] synthase activity"},{"category":"Function","description":" C-acyltransferase activity"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" fatty-acyl-CoA synthase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" macromolecule biosynthetic process"}],"pfams":[{"name":"ACPS","identifier":"PF01648"},{"name":"adh_short","identifier":"PF00106"},{"name":"ketoacyl-synt","identifier":"PF00109"},{"name":"Ketoacyl-synt_C","identifier":"PF02801"}],"pathways":[{"name":"Fatty acid biosynthesis","kegg_map_id":"00061"}],"gene_sequence":"ATGAAGCCGGAAGTTGAGCAAGAATTAGCTCATATTTTGCTAACTGAATTGTTAGCTTATCAATTTGCCTCTCCTGTGAGATGGATTGAAACTCAAGATGTTTTTTTGAAGGATTTTAACACTGAAAGGGTTGTTGAAATCGGTCCTTCTCCAACTTTGGCTGGGATGGCTCAAAGAACCTTGAAGAATAAATACGAATCTTACGATGCTGCTCTGTCTTTACATAGAGAAATCTTATGCTATTCGAAGGATGCCAAAGAGATTTATTATACCCCAGATCCATCCGAACTAGCTGCAAAGGAAGAGCCCGCTAAGGAAGAAGCTCCTGCTCCAACTCCAGCTGCTAGTGCTCCTGCTCCTGCAGCAGCAGCCCCAGCTCCCGTCGCGGCAGCAGCCCCAGCTGCAGCAGCTGCTGAGATTGCCGATGAACCTGTCAAGGCTTCCCTATTGTTGCACGTTTTGGTTGCTCACAAGTTGAAGAAGTCGTTAGATTCCATTCCAATGTCCAAGACAATCAAAGACTTGGTCGGTGGTAAATCTACAGTCCAAAATGAAATTTTGGGTGATTTAGGTAAAGAATTTGGTACTACTCCTGAAAAACCAGAAGAAACTCCATTAGAAGAATTGGCAGAAACTTTCCAAGATACCTTCTCTGGAGCATTGGGTAAGCAATCTTCCTCGTTATTATCAAGATTAATCTCATCTAAGATGCCTGGTGGGTTTACTATTACTGTCGCTAGAAAATACTTACAAACTCGCTGGGGACTACCATCTGGTAGACAAGATGGTGTCCTTTTGGTAGCTTTATCTAACGAGCCTGCTGCTCGTCTAGGTTCTGAAGCTGATGCCAAGGCTTTCTTGGACTCCATGGCTCAAAAATACGCTTCCATTGTTGGTGTTGACTTATCATCAGCTGCTAGCGCTAGTGGTGCTGCCGGTGCAGGTGCTGCTGCCGGTGCAGCTATGATCGATGCTGGCGCTCTGGAAGAAATAACCAAAGACCACAAGGTTTTGGCGCGTCAACAACTGCAAGTATTGGCTCGTTATCTAAAAATGGACTTGGATAACGGTGAAAGAAAGTTCTTGAAAGAAAAGGACACTGTTGCTGAACTTCAAGCTCAGTTGGATTACTTGAATGCCGAATTAGGTGAATTCTTTGTTAACGGTGTTGCTACTTCTTTCTCTAGAAAAAAGGCCAGAACCTTCGATTCTTCCTGGAACTGGGCTAAACAATCTTTATTATCATTATACTTTGAGATAATTCATGGTGTCTTGAAAAACGTTGATAGAGAGGTTGTTAGTGAAGCTATCAATATCATGAACAGATCTAACGATGCTTTGATTAAATTCATGGAATACCATATCTCTAACACTGATGAAACAAAAGGTGAAAACTATCAATTGGTTAAAACTCTTGGTGAGCAGTTGATTGAAAACTGTAAACAAGTTTTGGATGTTGATCCAGTTTACAAAGATGTTGCTAAGCCTACCGGTCCAAAAACTGCTATTGACAAGAACGGTAACATTACATACTCAGAAGAGCCAAGAGAAAAGGTTAGGAAATTATCTCAATACGTACAAGAAATGGCCCTTGGTGGTCCAATCACCAAAGAATCTCAACCTACTATTGAAGAGGATTTGACTCGTGTTTACAAGGCAATCAGTGCTCAAGCTGATAAACAAGATATTTCCAGCTCCACCAGGGTTGAATTTGAAAAACTATATAGTGATTTGATGAAGTTCTTGGAAAGCTCCAAAGAAATCGATCCTTCTCAAACAACCCAATTGGCCGGTATGGATGTTGAGGATGCTTTGGACAAAGATTCCACCAAAGAAGTTGCTTCTTTGCCAAACAAATCTACCATTTCTAAGACGGTATCTTCAACTATTCCAAGAGAAACTATTCCGTTCTTACATTTGAGAAAGAAGACTCCTGCCGGAGATTGGAAATATGACCGCCAATTGTCTTCTCTTTTCTTAGATGGTTTAGAAAAGGCTGCCTTCAACGGTGTCACCTTCAAGGACAAATACGTCTTGATCACTGGTGCTGGTAAGGGTTCTATTGGTGCTGAAGTCTTGCAAGGTTTGTTACAAGGTGGTGCTAAGGTTGTTGTTACCACCTCTCGTTTCTCTAAGCAAGTTACAGACTACTACCAATCCATTTACGCCAAATATGGTGCTAAGGGTTCTACTTTGATTGTTGTTCCATTCAACCAAGGTTCTAAGCAAGACGTTGAAGCTTTGATTGAATTTATCTACGACACTGAAAAGAATGGTGGTTTAGGTTGGGATCTAGATGCTATTATTCCATTCGCGGCCATTCCAGAACAAGGTATTGAATTAGAACATATTGATTCTAAGTCTGAATTTGCTCATAGAATCATGTTGACCAATATCTTAAGAATGATGGGTTGTGTCAAGAAGCAAAAATCTGCAAGAGGTATTGAAACAAGACCAGCTCAAGTCATTCTACCAATGTCTCCAAACCATGGTACTTTCGGTGGTGATGGTATGTATTCAGAATCCAAGTTGTCTTTGGAAACTTTGTTCAACAGATGGCACTCTGAATCCTGGGCCAATCAATTAACCGTTTGCGGTGCTATTATTGGTTGGACTAGAGGTACTGGTTTAATGAGCGCTAATAACATCATTGCTGAAGGCATTGAAAAGATGGGTGTTCGTACTTTCTCTCAAAAGGAAATGGCTTTCAACTTATTGGGTCTATTGACTCCAGAAGTCGTAGAATTGTGCCAAAAATCACCTGTTATGGCTGACTTGAATGGTGGTTTGCAATTTGTTCCTGAATTGAAGGAATTCACTGCTAAATTGCGTAAAGAGTTGGTTGAAACTTCTGAAGTTAGAAAGGCAGTTTCCATCGAAACTGCTTTGGAGCATAAGGTTGTCAATGGCAATAGCGCTGATGCTGCATATGCTCAAGTCGAAATTCAACCAAGAGCTAACATTCAACTGGACTTCCCAGAATTGAAACCATACAAACAGGTTAAACAAATTGCTCCCGCTGAGCTTGAAGGTTTGTTGGATTTGGAAAGAGTTATTGTAGTTACCGGTTTTGCTGAAGTCGGCCCATGGGGTTCGGCCAGAACAAGATGGGAAATGGAAGCTTTTGGTGAATTTTCGTTGGAAGGTTGCGTTGAAATGGCCTGGATTATGGGCTTCATTTCATACCATAACGGTAATTTGAAGGGTCGTCCATACACTGGTTGGGTTGATTCCAAAACAAAAGAACCAGTTGATGACAAGGACGTTAAGGCCAAGTATGAAACATCAATCCTAGAACACAGTGGTATCAGATTGATCGAACCAGAGTTATTCAATGGTTACAACCCAGAAAAGAAGGAAATGATTCAAGAAGTCATTGTCGAAGAAGACTTGGAACCATTTGAGGCTTCGAAGGAAACTGCCGAACAATTTAAACACCAACATGGTGACAAAGTGGATATCTTCGAAATCCCAGAAACAGGAGAGTACTCTGTTAAGTTACTAAAGGGTGCCACTTTATACATTCCAAAGGCTTTGAGATTTGACCGTTTGGTTGCAGGTCAAATTCCAACTGGTTGGAATGCTAAGACTTATGGTATCTCTGATGATATCATTTCTCAGGTTGACCCAATCACATTATTCGTTTTGGTCTCTGTTGTGGAAGCATTTATTGCATCTGGTATCACCGACCCATACGAAATGTACAAATACGTACATGTTTCTGAGGTTGGTAACTGTTCTGGTTCTGGTATGGGTGGTGTTTCTGCCTTACGTGGTATGTTTAAGGACCGTTTCAAGGATGAGCCTGTCCAAAATGATATTTTACAAGAATCATTTATCAACACCATGTCCGCTTGGGTTAATATGTTGTTGATTTCCTCATCTGGTCCAATCAAGACACCTGTTGGTGCCTGTGCCACATCCGTGGAATCTGTTGACATTGGTGTAGAAACCATCTTGTCTGGTAAGGCTAGAATCTGTATTGTCGGTGGTTACGATGATTTCCAAGAAGAAGGCTCCTTTGAGTTCGGTAACATGAAGGCCACTTCCAACACTTTGGAAGAATTTGAACATGGTCGTACCCCAGCGGAAATGTCCAGACCTGCCACCACTACCCGTAACGGTTTTATGGAAGCTCAAGGTGCTGGTATTCAAATCATCATGCAAGCTGATTTAGCTTTGAAGATGGGTGTGCCAATTTACGGTATTGTTGCCATGGCTGCTACCGCCACCGATAAGATTGGTAGATCTGTGCCAGCTCCAGGTAAGGGTATTTTAACCACTGCTCGTGAACACCACTCCAGTGTTAAGTATGCTTCACCAAACTTGAACATGAAGTACAGAAAGCGCCAATTGGTTACTCGTGAAGCTCAGATTAAAGATTGGGTAGAAAACGAATTGGAAGCTTTGAAGTTGGAGGCCGAAGAAATTCCAAGCGAAGACCAAAACGAGTTCTTACTTGAACGTACCAGAGAAATCCACAACGAAGCTGAAAGTCAATTGAGAGCTGCACAACAACAATGGGGTAACGACTTCTACAAGAGGGACCCACGTATTGCTCCATTGAGAGGAGCACTGGCTACTTACGGTTTAACTATTGATGACTTGGGTGTCGCTTCATTCCACGGTACATCCACAAAGGCTAATGACAAGAACGAATCTGCCACAATTAATGAAATGATGAAGCATTTGGGTAGATCTGAAGGTAATCCCGTCATTGGTGTTTTCCAAAAGTTCTTGACTGGTCATCCAAAGGGTGCTGCTGGTGCATGGATGATGAATGGTGCTTTGCAAATTCTAAACAGTGGTATTATTCCAGGTAACCGTAACGCTGATAACGTGGATAAGATCTTGGAGCAATTTGAATACGTCTTGTACCCATCCAAGACTTTAAAGACCGACGGTGTCAGAGCCGTGTCCATCACTTCTTTCGGTTTTGGTCAAAAGGGTGGTCAAGCTATTGTGGTTCATCCAGACTACTTATACGGTGCTATCACTGAAGACAGATACAACGAGTATGTCGCCAAGGTTAGTGCCAGAGAGAAAAGTGCCTACAAATTCTTCCATAATGGTATGATCTACAACAAGTTGTTCGTAAGTAAAGAGCATGCTCCATACACTGATGAATTGGAAGAGGATGTTTACTTGGACCCATTAGCCCGTGTATCTAAGGATAAGAAATCAGGCTCCTTGACTTTCAACTCTAAAAACATCCAAAGCAAGGACAGTTACATCAATGCTAACACCATTGAAACTGCCAAGATGATTGAAAACATGACCAAGGAGAAAGTCTCTAACGGTGGCGTCGGTGTAGATGTTGAATTAATCACTAGCATCAACGTTGAAAATGATACTTTTATCGAGCGCAATTTCACCCCGCAAGAAATAGAGTACTGCAGCGCGCAGCCTAGTGTGCAAAGCTCTTTCGCTGGGACATGGTCCGCCAAAGAGGCTGTTTTCAAGTCCTTAGGCGTCAAGTCCTTAGGCGGTGGTGCTGCATTGAAAGACATCGAAATCGTACGCGTTAACAAAAACGCTCCAGCCGTTGAACTGCACGGTAACGCCAAAAAGGCTGCCGAAGAAGCTGGTGTTACCGATGTGAAGGTATCTATTTCTCACGATGACCTCCAAGCTGTCGCGGTCGCCGTTTCTACTAAGAAATAG","protein_sequence":"MKPEVEQELAHILLTELLAYQFASPVRWIETQDVFLKDFNTERVVEIGPSPTLAGMAQRTLKNKYESYDAALSLHREILCYSKDAKEIYYTPDPSELAAKEEPAKEEAPAPTPAASAPAPAAAAPAPVAAAAPAAAAAEIADEPVKASLLLHVLVAHKLKKSLDSIPMSKTIKDLVGGKSTVQNEILGDLGKEFGTTPEKPEETPLEELAETFQDTFSGALGKQSSSLLSRLISSKMPGGFTITVARKYLQTRWGLPSGRQDGVLLVALSNEPAARLGSEADAKAFLDSMAQKYASIVGVDLSSAASASGAAGAGAAAGAAMIDAGALEEITKDHKVLARQQLQVLARYLKMDLDNGERKFLKEKDTVAELQAQLDYLNAELGEFFVNGVATSFSRKKARTFDSSWNWAKQSLLSLYFEIIHGVLKNVDREVVSEAINIMNRSNDALIKFMEYHISNTDETKGENYQLVKTLGEQLIENCKQVLDVDPVYKDVAKPTGPKTAIDKNGNITYSEEPREKVRKLSQYVQEMALGGPITKESQPTIEEDLTRVYKAISAQADKQDISSSTRVEFEKLYSDLMKFLESSKEIDPSQTTQLAGMDVEDALDKDSTKEVASLPNKSTISKTVSSTIPRETIPFLHLRKKTPAGDWKYDRQLSSLFLDGLEKAAFNGVTFKDKYVLITGAGKGSIGAEVLQGLLQGGAKVVVTTSRFSKQVTDYYQSIYAKYGAKGSTLIVVPFNQGSKQDVEALIEFIYDTEKNGGLGWDLDAIIPFAAIPEQGIELEHIDSKSEFAHRIMLTNILRMMGCVKKQKSARGIETRPAQVILPMSPNHGTFGGDGMYSESKLSLETLFNRWHSESWANQLTVCGAIIGWTRGTGLMSANNIIAEGIEKMGVRTFSQKEMAFNLLGLLTPEVVELCQKSPVMADLNGGLQFVPELKEFTAKLRKELVETSEVRKAVSIETALEHKVVNGNSADAAYAQVEIQPRANIQLDFPELKPYKQVKQIAPAELEGLLDLERVIVVTGFAEVGPWGSARTRWEMEAFGEFSLEGCVEMAWIMGFISYHNGNLKGRPYTGWVDSKTKEPVDDKDVKAKYETSILEHSGIRLIEPELFNGYNPEKKEMIQEVIVEEDLEPFEASKETAEQFKHQHGDKVDIFEIPETGEYSVKLLKGATLYIPKALRFDRLVAGQIPTGWNAKTYGISDDIISQVDPITLFVLVSVVEAFIASGITDPYEMYKYVHVSEVGNCSGSGMGGVSALRGMFKDRFKDEPVQNDILQESFINTMSAWVNMLLISSSGPIKTPVGACATSVESVDIGVETILSGKARICIVGGYDDFQEEGSFEFGNMKATSNTLEEFEHGRTPAEMSRPATTTRNGFMEAQGAGIQIIMQADLALKMGVPIYGIVAMAATATDKIGRSVPAPGKGILTTAREHHSSVKYASPNLNMKYRKRQLVTREAQIKDWVENELEALKLEAEEIPSEDQNEFLLERTREIHNEAESQLRAAQQQWGNDFYKRDPRIAPLRGALATYGLTIDDLGVASFHGTSTKANDKNESATINEMMKHLGRSEGNPVIGVFQKFLTGHPKGAAGAWMMNGALQILNSGIIPGNRNADNVDKILEQFEYVLYPSKTLKTDGVRAVSITSFGFGQKGGQAIVVHPDYLYGAITEDRYNEYVAKVSAREKSAYKFFHNGMIYNKLFVSKEHAPYTDELEEDVYLDPLARVSKDKKSGSLTFNSKNIQSKDSYINANTIETAKMIENMTKEKVSNGGVGVDVELITSINVENDTFIERNFTPQEIEYCSAQPSVQSSFAGTWSAKEAVFKSLGVKSLGGGAALKDIEIVRVNKNAPAVELHGNAKKAAEEAGVTDVKVSISHDDLQAVAVAVSTKK"},{"created_at":"2011-05-26T19:49:11.000Z","updated_at":"2011-07-22T17:53:54.000Z","name":"Acetyl-CoA carboxylase, mitochondrial","uniprot_id":"P32874","uniprot_name":"HFA1_YEAST","enzyme":true,"transporter":false,"gene_name":"HFA1","num_residues":2273,"molecular_weight":"259161.0","theoretical_pi":"8.95","general_function":"Involved in acetyl-CoA carboxylase activity","specific_function":"Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway. Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid. This protein carries three functions:biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase","reactions":[{"id":1239,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2586,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":2587,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"D78165","genbank_protein_id":"2804173","gene_card_id":"HFA1","chromosome_location":"chromosome 13","locus":"YMR207C","synonyms":["ACC","Biotin carboxylase"],"enzyme_classes":["6.4.1.2","6.3.4.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" biotin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-carbon bonds"},{"category":"Function","description":" CoA carboxylase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" acetyl-CoA carboxylase activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"Biotin_carb_C","identifier":"PF02785"},{"name":"Biotin_lipoyl","identifier":"PF00364"},{"name":"ACC_central","identifier":"PF08326"},{"name":"Carboxyl_trans","identifier":"PF01039"}],"pathways":[{"name":"Fatty acid biosynthesis","kegg_map_id":"00061"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Propanoate metabolism","kegg_map_id":"00640"}],"gene_sequence":"AAAGGGAAGACAATTACACACGGCCAAAGCTGGGGGGCTCGCCGGATACATTCTCACTTTTACATTACCATATTCACAATTACTTGCATTCGAATAGGACAGTACAAGCTCGCGTTATATTTGGATCCTTATCGATTCTATAATATAACGGGCAGCCAGATAGTACGGTTGAAAGGACAGCGCCCTGAATACAGAAAACGCATTTTTGCCCATTCGTATAGGCATTCATCTCGAATAGGTTTGAATTTTCCATCTAGAAGAAGGTATTCCAATTATGTGGATCGAGGCAATATTCATAAACATACTCGATTACCGCCCCAGTTCATAGGGCTAAATACTGTGGAAAGTGCCCAACCTTCAATATTAAGAGATTTTGTTGATTTACGTGGTGGACATACTGTTATTTCAAAGATCTTAATAGCAAACAATGGTATTGCTGCGGTGAAAGAAATGAGATCTATAAGAAAATGGGCGTACGAGACGTTCAATGATGAAAAAATCATTCAATTCGTGGTAATGGCGACACCTGATGATTTACACGCAAATTCGGAGTATATTAGAATGGCAGACCAATATGTGCAGGTACCAGGGGGTACCAACAACAACAATTACGCCAACATAGACTTAATACTGGACGTGGCAGAGCAAACGGATGTGGATGCGGTCTGGGCTGGATGGGGCCATGCTTCTGAAAATCCGTGTCTTCCTGAGCTGTTAGCTAGTTCACAAAGGAAAATACTATTCATTGGTCCTCCTGGGCGCGCTATGAGATCATTGGGTGACAAGATTTCTTCCACTATTGTAGCACAAAGCGCTAAAATCCCGTGTATCCCTTGGTCTGGTTCACATATAGACACTATCCATATCGATAACAAGACGAACTTTGTATCTGTGCCGGATGATGTATATGTAAGGGGATGTTGTTCCTCACCTGAAGATGCTTTAGAAAAGGCTAAATTAATAGGATTTCCTGTAATGATTAAGGCATCCGAAGGTGGTGGAGGTAAGGGCATTAGGCGAGTAGATAATGAGGATGATTTTATTGCATTATATCGCCAAGCAGTGAATGAGACACCTGGGTCGCCTATGTTTGTTATGAAAGTTGTCACTGATGCTCGTCACTTAGAGGTACAGTTATTAGCTGACCAATATGGCACTAACATTACATTGTTTGGGAGAGACTGTTCCATACAAAGGCGGCACCAAAAGATTATAGAAGAGGCACCAGTGACAATAACCAAGCCTGAAACGTTTCAAAGGATGGAACGCGCAGCAATTCGTCTAGGTGAATTGGTAGGTTATGTTTCTGCGGGCACTGTCGAATACTTATATTCACCAAAAGATGATAAATTTTACTTTTTAGAACTGAATCCGAGACTACAAGTAGAGCATCCAACGACAGAAATGATATCTGGCGTAAACCTTCCTGCCACTCAACTGCAAATCGCCATGGGCATTCCTATGCACATGATAAGTGATATCAGAAAACTTTATGGTTTAGATCCAACGGGAACTTCGTATATTGATTTTAAAAATTTAAAGAGACCCTCGCCAAAAGGCCATTGTATTTCATGCAGGATCACTTCAGAAGATCCTAATGAAGGTTTCAAGCCCTCCACTGGGAAAATACATGAGCTCAATTTTCGTTCTTCTTCCAATGTTTGGGGTTACTTCTCAGTAGGAAATAATGGTGCTATTCACTCATTTTCAGATTCCCAATTTGGGCACATTTTTGCTGTAGGAAACGATAGGCAAGATGCAAAGCAAAACATGGTTTTAGCTCTAAAAGATTTTTCCATCCGAGGAGAATTCAAAACCCCCATAGAGTACCTGATAGAGCTATTAGAAACTCGGGACTTTGAGAGTAATAACATATCGACTGGTTGGTTAGATGATTTGATTTTGAAAAATTTATCTTCCGATAGCAAACTAGATCCAACGCTCGCTATTATCTGTGGTGCCGCAATGAAAGCATACGTTTTCACAGAAAAGGTGAGGAATAAGTATTTGGAATTATTGCGGAGGGGCCAAGTTCCACCTAAAGATTTTCTTAAAACGAAGTTTCCTGTTGACTTCATTTTCGATAATAATAGATACTTGTTCAATGTTGCTCAATCATCTGAAGAACAATTTATTCTTTCTATCAATAAGTCTCAATGTGAAGTTAATGTTCAAAAATTGTCCAGTGACTGCTTGTTGATCTCCGTTGACGGTAAATGCCATACAGTTTATTGGAAGGACGATATCAGAGGTACAAGACTTTCGATAGACTCCAATACCATATTTTTAGAAGCTGAACTCAATCCCACTCAAGTGATCTCTCCAACTCCGGGGAAATTGGTGAAATATTTGGTCCGAAGTGGTGATCACGTTTTTGCTGGACAGCAATATGCAGAAATAGAAATAATGAAAATGCAGATGCCACTAGTAGCGAAAAGTGATGGTGTAATTGAGTTACTAAGACAGCCCGGTTCCATAATTGAGGCTGGTGATGTCATCGCAAAATTGACTTTGGATTCGCCGTCCAAAGCTAACGAATCGTCTTTATACCGCGGAGAATTACCTGTTTTAGGTCCACCGCTAATAGAGGGTAGCCGACCAAACCATAAGCTCAGAGTCTTAATAAATAGGTTAGAAAATATTCTCAATGGATATCATGAAAACTCTGGAATAGAAACTACTCTAAAAGAGTTGATAAAAATATTGAGAGATGGTAGGCTTCCTTATTCAGAATGGGATTCCCAAATTTCTACGGTACGCAATAGACTACCAAGGCAATTGAATGAGGGGCTGGGAAATCTAGTCAAGAAATCTGTTTCTTTTCCTGCAAAGGAACTGCACAAATTAATGAAGCGCTACTTGGAAGAAAATACAAATGATCATGTAGTTTATGTTGCCTTACAGCCACTTCTTAAAATTAGTGAAAGGTATAGCGAAGGTTTAGCTAATCACGAATGTGAAATTTTTTTAAAGTTGATTAAAAAGTACTATGCTGTTGAGAAAATTTTTGAAAATCATGATATACATGAAGAAAGAAACTTACTAAATCTGCGGAGGAAAGACCTTACAAACTTAAAAGAAATTTTGTGCATAAGTTTATCGCATGCTAACGTAGTCGCAAAGAACAAGTTAGTAACTGCAATATTGCATGAATACGAGCCATTGTGCCAGGATTCCTCTAAGATGTCTTTAAAATTCAGGGCTGTTATACATGATTTGGCAAGTTTGGAATCTAAGTGGGCTAAAGAGGTTGCTGTAAAGGCAAGATCAGTGCTACTCAGAGGGATTTTCCCTCCCATAAAGAAAAGAAAAGAGCATATTAAAACTCTCCTGCAATTGCACATAAAGGATACTGGTGCCGAAAACATTCACAGCAGGAACATATATTCCTGTATGAGGGATTTTGGTAATTTAATACATTCAAATCTGATACAACTTCAGGATTTGTTCTTTTTTTTTGGCCATCAAGATACGGCTCTTTCCAGTATAGCATCTGAAATTTATGCAAGGTATGCCTACGGCAATTATCAATTAAAAAGTATTAAGATTCATAAAGGAGCGCCTGATTTACTAATGTCATGGCAATTCAGCTCATTAAGAAATTATTTAGTCAATTCTGATGGTGAGAGTGATGAGTTTACAAAACTTTCTAAACCTCCCTCAACATCAGGTAAGAGCTCAGCAAATAGTTTTGGTCTTCTTGTCAACATGCGTGCGCTTGAATCTCTGGAAAAGACATTAGACGAGGTATACGAACAAATTCATATTCCTGAGGAAAGACTTTCCAGCGGAGAGAACTCTCTTATTGTTAATATTTTATCTCCTATTCGTTACAGAAGTGAAAATGATCTAATTAAAACTTTAAAAATTAAACTTCATGAAAATGAGAGAGGTCTATCCAAGCTCAAGGTTAATCGTATTACATTTGCATTTATCGCCGCGAATGCGCCCGCTGTTAAATTTTACTCCTTTGATGGAACTACGTACGATGAAATCTCTCAAATAAGAAATATGGATCCATCCTATGAAGCACCGTTAGAGTTAGGAAAAATGTCGAACTATAAAATCAGATCACTACCTACATACGATAGTAGTATACGCATTTTTGAAGGTATTAGCAAATTTACGCCGCTAGATAAAAGGTTCTTTGTCAGGAAAATCATAAATTCCTTCATGTATAATGATCAAAAAACAACCGAAGAAAACTTGAAAGCGGAAATCAATGCTCAAGTGGTTTATATGTTAGAACATCTAGGAGCAGTTGACATCTCAAATTCAGACTTGAATCATATTTTTTTAAGTTTCAATACAGTTCTTAACATACCAGTACATCGTCTCGAGGAAATTGTGAGTACAATTCTAAAGACTCACGAAACCAGATTGTTTCAAGAAAGAATCACAGATGTAGAAATTTGCATCTCTGTTGAGTGCCTAGAAACAAAGAAGCCAGCCCCGCTTAGATTACTTATTTCTAATAAATCTGGGTATGTGGTAAAAATTGAGACATATTACGAAAAGATAGGGAAAAATGGGAATCTGATTTTGGAACCGTGTAGTGAGCAGAGCCATTATAGCCAGAAATCTCTCTCTCTTCCTTACTCGGTCAAGGATTGGCTACAACCTAAAAGGTACAAAGCTCAATTCATGGGTACAACATATGTGTACGATTTCCCAGGTCTGTTTCATCAAGCTGCAATCCAACAGTGGAAAAGGTATTTTCCAAAACATAAGCTGAATGACAGTTTTTTTAGTTGGGTTGAATTGATAGAACAAAACGGTAATTTAATAAAAGTAAACAGGGAGCCAGGCCTTAATAATATAGGGATGGTTGCTTTTGAGATTATGGTTCAGACACCTGAATATCCTGAAGGGCGTAACATGATCGTGATTTCTAATGATATTACCTACAATATTGGATCTTTTGGACCGAGAGAAGATTTGTTTTTTGATAGGGTCACAAATTATGCAAGAGAGAGAGGGATCCCGAGGATATACTTGGCGGCGAATTCAGGAGCTAAATTGGGTATAGCCGAAGAGCTGATCCCTCTATTTCGTGTAGCATGGAATGACCCCTCTGATCCAACAAAGGGTTTCCAGTACTTATACTTAGCTCCAAAAGACATGCAGCTACTGAAAGATTCTGGGAAAGGAAATTCGGTTGTTGTTGAACACAAGATGGTATACGGTGAAGAGAGATATATTATTAAAGCAATAGTCGGATTCGAAGAGGGTTTAGGTGTTGAATGTTTACAGGGCTCGGGTTTAATTGCTGGTGCCACTTCGAAAGCGTATAGAGACATTTTCACTATTACTGCTGTTACTTGTCGGTCCGTTGGTATAGGTTCCTATCTGGTCAGACTAGGACAACGTACTATTCAGGTGGAGGATAAGCCTATCATACTGACGGGTGCATCGGCGATTAATAAAGTTTTGGGTACCGATATCTATACATCTAACCTACAAATTGGCGGAACCCAAATCATGTATAAAAACGGAATAGCGCATTTAACAGCCAGTAATGATATGAAAGCCATCGAAAAAATAATGACATGGTTATCATATGTCCCGGCGAAAAGAGATATGAGTCCTCCACTTCTTGAAACTATGGATAGATGGGATAGGGATGTAGACTTCAAACCTGCCAAGCAAGTGCCATATGAGGCAAGGTGGTTGATAGAGGGTAAATGGGACTCAAATAACAACTTCCAGTCAGGCCTATTTGATAAGGATTCGTTTTTTGAGACATTATCTGGATGGGCCAAAGGTGTAATAGTTGGAAGAGCACGTCTTGGAGGTATTCCCGTGGGTGTTATTGCGGTAGAAACTAAGACTATCGAAGAAATAATCCCCGCTGACCCAGCTAATCTGGATTCTTCAGAGTTTTCCGTTAAAGAAGCAGGACAGGTGTGGTATCCAAATTCCGCGTTCAAAACAGCTCAAACTATAAATGATTTTAACTATGGTGAGCAATTACCATTGATTATCTTAGCCAATTGGAGGGGATTTTCTGGCGGTCAAAGGGATATGTACAATGAAGTACTAAAGTACGGGTCTTTTATTGTTGACGCTCTGGTTGACTACAAACAACCCATACTGATATACATTCCGCCCTTTGGTGAATTAAGGGGCGGATCATGGGTTGTTATAGATCCAACTATTAATCCTGAACAAATGGAAATGTATGCCGATGTTGAATCTAGGGGAGGTGTGTTAGAACCTGACGGAGTAGTTAGCATAAAATACCGTAAGGAGAAAATGATAGAGACGATGATTCGATTAGACTCCACATATGGACATTTGAGAAGAACGTTGACAGAAAAAAAGTTATCTTTGGAAAAACAAAATGATCTTACGAAGAGATTGAAAATAAGAGAGAGACAGTTGATACCAATTTACAATCAAATCAGCATACAGTTTGCAGATTTACATGATAGATCGACTAGGATGCTAGTTAAAGGAGTAATCCGAAATGAGTTGGAATGGAAAAAGTCACGCAGATTTTTATATTGGAGACTGAGAAGGAGGTTGAACGAGGGACAAGTGATCAAAAGACTGCAAAAAAAAACATGTGATAACAAAACGAAAATGAAGTACGACGACCTGTTGAAAATAGTTCAGTCATGGTATAACGATCTGGATGTTAATGATGACAGAGCAGTAGTGGAGTTCATAGAAAGAAATTCGAAAAAAATTGACAAGAACATTGAAGAGTTTGAGATCTCGCTGTTGATCGATGAGCTTAAGAAAAAATTTGAAGACAGAAGGGGAAACATTGTCCTTGAAGAGCTAACTAGGTTGGTGGACAGTAAGCGAAAGAGATAG","protein_sequence":"KGKTITHGQSWGARRIHSHFYITIFTITCIRIGQYKLALYLDPYRFYNITGSQIVRLKGQRPEYRKRIFAHSYRHSSRIGLNFPSRRRYSNYVDRGNIHKHTRLPPQFIGLNTVESAQPSILRDFVDLRGGHTVISKILIANNGIAAVKEMRSIRKWAYETFNDEKIIQFVVMATPDDLHANSEYIRMADQYVQVPGGTNNNNYANIDLILDVAEQTDVDAVWAGWGHASENPCLPELLASSQRKILFIGPPGRAMRSLGDKISSTIVAQSAKIPCIPWSGSHIDTIHIDNKTNFVSVPDDVYVRGCCSSPEDALEKAKLIGFPVMIKASEGGGGKGIRRVDNEDDFIALYRQAVNETPGSPMFVMKVVTDARHLEVQLLADQYGTNITLFGRDCSIQRRHQKIIEEAPVTITKPETFQRMERAAIRLGELVGYVSAGTVEYLYSPKDDKFYFLELNPRLQVEHPTTEMISGVNLPATQLQIAMGIPMHMISDIRKLYGLDPTGTSYIDFKNLKRPSPKGHCISCRITSEDPNEGFKPSTGKIHELNFRSSSNVWGYFSVGNNGAIHSFSDSQFGHIFAVGNDRQDAKQNMVLALKDFSIRGEFKTPIEYLIELLETRDFESNNISTGWLDDLILKNLSSDSKLDPTLAIICGAAMKAYVFTEKVRNKYLELLRRGQVPPKDFLKTKFPVDFIFDNNRYLFNVAQSSEEQFILSINKSQCEVNVQKLSSDCLLISVDGKCHTVYWKDDIRGTRLSIDSNTIFLEAELNPTQVISPTPGKLVKYLVRSGDHVFAGQQYAEIEIMKMQMPLVAKSDGVIELLRQPGSIIEAGDVIAKLTLDSPSKANESSLYRGELPVLGPPLIEGSRPNHKLRVLINRLENILNGYHENSGIETTLKELIKILRDGRLPYSEWDSQISTVRNRLPRQLNEGLGNLVKKSVSFPAKELHKLMKRYLEENTNDHVVYVALQPLLKISERYSEGLANHECEIFLKLIKKYYAVEKIFENHDIHEERNLLNLRRKDLTNLKKILCISLSHANVVAKNKLVTAILHEYEPLCQDSSKMSLKFRAVIHDLASLESKWAKEVAVKARSVLLRGIFPPIKKRKEHIKTLLQLHIKDTGAENIHSRNIYSCMRDFGNLIHSNLIQLQDLFFFFGHQDTALSSIASEIYARYAYGNYQLKSIKIHKGAPDLLMSWQFSSLRNYLVNSDGESDEFTKLSKPPSTSGKSSANSFGLLVNMRALESLEKTLDEVYEQIHIPEERLSSGENSLIVNILSPIRYRSENDLIKTLKIKLHENERGLSKLKVNRITFAFIAANAPAVKFYSFDGTTYDEISQIRNMDPSYEAPLELGKMSNYKIRSLPTYDSSIRIFEGISKFTPLDKRFFVRKIINSFMYNDQKTTEENLKAEINAQVVYMLEHLGAVDISNSDLNHIFLSFNTVLNIPVHRLEEIVSTILKTHETRLFQERITDVEICISVECLETKKPAPLRLLISNKSGYVVKIETYYEKIGKNGNLILEPCSEQSHYSQKSLSLPYSVKDWLQPKRYKAQFMGTTYVYDFPGLFHQAAIQQWKRYFPKHKLNDSFFSWVELIEQNGNLIKVNREPGLNNIGMVAFEIMVQTPEYPEGRNMIVISNDITYNIGSFGPREDLFFDRVTNYARERGIPRIYLAANSGAKLGIAEELIPLFRVAWNDPSDPTKGFQYLYLAPKDMQLLKDSGKGNSVVVEHKMVYGEERYIIKAIVGFEEGLGVECLQGSGLIAGATSKAYRDIFTITAVTCRSVGIGSYLVRLGQRTIQVEDKPIILTGASAINKVLGTDIYTSNLQIGGTQIMYKNGIAHLTASNDMKAIEKIMTWLSYVPAKRDMSPPLLETMDRWDRDVDFKPAKQVPYEARWLIEGKWDSNNNFQSGLFDKDSFFETLSGWAKGVIVGRARLGGIPVGVIAVETKTIEEIIPADPANLDSSEFSVKEAGQVWYPNSAFKTAQTINDFNYGEQLPLIILANWRGFSGGQRDMYNEVLKYGSFIVDALVDYKQPILIYIPPFGELRGGSWVVIDPTINPEQMEMYADVESRGGVLEPDGVVSIKYRKEKMIETMIRLDSTYGHLRRTLTEKKLSLEKQNDLTKRLKIRERQLIPIYNQISIQFADLHDRSTRMLVKGVIRNELEWKKSRRFLYWRLRRRLNEGQVIKRLQKKTCDNKTKMKYDDLLKIVQSWYNDLDVNDDRAVVEFIERNSKKIDKNIEEFEISLLIDELKKKFEDRRGNIVLEELTRLVDSKRKR"},{"created_at":"2011-05-26T21:15:10.000Z","updated_at":"2011-07-22T17:53:54.000Z","name":"Acetyl-CoA carboxylase","uniprot_id":"Q00955","uniprot_name":"ACAC_YEAST","enzyme":true,"transporter":false,"gene_name":"FAS3","num_residues":2233,"molecular_weight":"250351.0","theoretical_pi":"6.21","general_function":"Involved in acetyl-CoA carboxylase activity","specific_function":"Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase","reactions":[{"id":1239,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2586,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":2587,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].","export":false,"pw_reaction_id":null,"source":null},{"id":3705,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003286","source":"Smpdb"},{"id":3706,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006568","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1OD4","cellular_location":"Cytoplasm","genbank_gene_id":"Z71631","genbank_protein_id":"1302498","gene_card_id":"FAS3","chromosome_location":null,"locus":"YNR016C","synonyms":["ACC","Biotin carboxylase"],"enzyme_classes":["6.4.1.2","6.3.4.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" biotin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-carbon bonds"},{"category":"Function","description":" CoA carboxylase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" acetyl-CoA carboxylase activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"Biotin_carb_C","identifier":"PF02785"},{"name":"Biotin_lipoyl","identifier":"PF00364"},{"name":"ACC_central","identifier":"PF08326"},{"name":"Carboxyl_trans","identifier":"PF01039"}],"pathways":[{"name":"Fatty acid biosynthesis","kegg_map_id":"00061"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGAGCGAAGAAAGCTTATTCGAGTCTTCTCCACAGAAGATGGAGTACGAAATTACAAACTACTCAGAAAGACATACAGAACTTCCAGGTCATTTCATTGGCCTCAATACAGTAGATAAACTAGAGGAGTCCCCGTTAAGGGACTTTGTTAAGAGTCACGGTGGTCACACGGTCATATCCAAGATCCTGATAGCAAATAATGGTATTGCCGCCGTGAAAGAAATTAGATCCGTCAGAAAATGGGCATACGAGACGTTCGGCGATGACAGAACCGTCCAATTCGTCGCCATGGCCACCCCAGAAGATCTGGAGGCCAACGCAGAATATATCCGTATGGCCGATCAATACATTGAAGTGCCAGGTGGTACTAATAATAACAACTACGCTAACGTAGACTTGATCGTAGACATCGCCGAAAGAGCAGACGTAGACGCCGTATGGGCTGGCTGGGGTCACGCCTCCGAGAATCCACTATTGCCTGAAAAATTGTCCCAGTCTAAGAGGAAAGTCATCTTTATTGGGCCTCCAGGTAACGCCATGAGGTCTTTAGGTGATAAAATCTCCTCTACCATTGTCGCTCAAAGTGCTAAAGTCCCATGTATTCCATGGTCTGGTACCGGTGTTGACACCGTTCACGTGGACGAGAAAACCGGTCTGGTCTCTGTCGACGATGACATCTATCAAAAGGGTTGTTGTACCTCTCCTGAAGATGGTTTACAAAAGGCCAAGCGTATTGGTTTTCCTGTCATGATTAAGGCATCCGAAGGTGGTGGTGGTAAAGGTATCAGACAAGTTGAACGTGAAGAAGATTTCATCGCTTTATACCACCAGGCAGCCAACGAAATTCCAGGCTCCCCCATTTTCATCATGAAGTTGGCCGGTAGAGCGCGTCACTTGGAAGTTCAACTGCTAGCAGATCAGTACGGTACAAATATTTCCTTGTTCGGTAGAGACTGTTCCGTTCAGAGACGTCATCAAAAAATTATCGAAGAAGCACCAGTTACAATTGCCAAGGCTGAAACATTTCACGAGATGGAAAAGGCTGCCGTCAGACTGGGGAAACTAGTCGGTTATGTCTCTGCCGGTACCGTGGAGTATCTATATTCTCATGATGATGGAAAATTCTACTTTTTAGAATTGAACCCAAGATTACAAGTCGAGCATCCAACAACGGAAATGGTCTCCGGTGTTAACTTACCTGCAGCTCAATTACAAATCGCTATGGGTATCCCTATGCATAGAATAAGTGACATTAGAACTTTATATGGTATGAATCCTCATTCTGCCTCAGAAATCGATTTCGAATTCAAAACTCAAGATGCCACCAAGAAACAAAGAAGACCTATTCCAAAGGGTCATTGTACCGCTTGTCGTATCACATCAGAAGATCCAAACGATGGATTCAAGCCATCGGGTGGTACTTTGCATGAACTAAACTTCCGTTCTTCCTCTAATGTTTGGGGTTACTTCTCCGTGGGTAACAATGGTAATATTCACTCCTTTTCGGACTCTCAGTTCGGCCATATTTTTGCTTTTGGTGAAAATAGACAAGCTTCCAGGAAACACATGGTTGTTGCCCTGAAGGAATTGTCCATTAGGGGTGATTTCAGAACTACTGTGGAATACTTGATCAAACTTTTGGAAACTGAAGATTTCGAGGATAACACTATTACCACCGGTTGGTTGGACGATTTGATTACTCATAAAATGACCGCTGAAAAGCCTGATCCAACTCTTGCCGTCATTTGCGGTGCCGCTACAAAGGCTTTCTTAGCATCTGAAGAAGCCCGCCACAAGTATATCGAATCCTTACAAAAGGGACAAGTTCTATCTAAAGACCTACTGCAAACTATGTTCCCTGTAGATTTTATCCATGAGGGTAAAAGATACAAGTTCACCGTAGCTAAATCCGGTAATGACCGTTACACATTATTTATCAATGGTTCTAAATGTGATATCATACTGCGTCAACTATCTGATGGTGGTCTTTTGATTGCCATAGGCGGTAAATCGCATACCATCTATTGGAAAGAAGAAGTTGCTGCTACAAGATTATCCGTTGACTCTATGACTACTTTGTTGGAAGTTGAAAACGATCCAACCCAGTTGCGTACTCCATCCCCTGGTAAATTGGTTAAATTCTTGGTGGAAAATGGTGAACACATTATCAAGGGCCAACCATATGCAGAAATTGAAGTTATGAAAATGCAAATGCCTTTGGTTTCTCAAGAAAATGGTATCGTCCAGTTATTAAAGCAACCTGGTTCTACCATTGTTGCAGGTGATATCATGGCTATTATGACTCTTGACGATCCATCCAAGGTCAAGCACGCTCTACCATTTGAAGGTATGCTGCCAGATTTTGGTTCTCCAGTTATCGAAGGAACCAAACCTGCCTATAAATTCAAGTCATTAGTGTCTACTTTGGAAAACATTTTGAAGGGTTATGACAACCAAGTTATTATGAACGCTTCCTTGCAACAATTGATAGAGGTTTTGAGAAATCCAAAACTGCCTTACTCAGAATGGAAACTACACATCTCTGCTTTACATTCAAGATTGCCTGCTAAGCTAGATGAACAAATGGAAGAGTTAGTTGCACGTTCTTTGAGACGTGGTGCTGTTTTCCCAGCTAGACAATTAAGTAAATTGATTGATATGGCCGTGAAGAATCCTGAATACAACCCCGACAAATTGCTGGGCGCCGTCGTGGAACCATTGGCGGATATTGCTCATAAGTACTCTAACGGGTTAGAAGCCCATGAACATTCTATATTTGTCCATTTCTTGGAAGAATATTACGAAGTTGAAAAGTTATTCAATGGTCCAAATGTTCGTGAGGAAAATATCATTCTGAAATTGCGTGATGAAAACCCTAAAGATCTAGATAAAGTTGCGCTAACTGTTTTGTCTCATTCGAAAGTTTCAGCGAAGAATAACCTGATCCTAGCTATCTTGAAACATTATCAACCATTGTGCAAGTTATCTTCTAAAGTTTCTGCCATTTTCTCTACTCCTCTACAACATATTGTTGAACTAGAATCTAAGGCTACCGCTAAGGTCGCTCTACAAGCAAGAGAAATTTTGATTCAAGGCGCTTTACCTTCGGTCAAGGAAAGAACTGAACAAATTGAACATATCTTAAAATCCTCTGTTGTGAAGGTTGCCTATGGCTCATCCAATCCAAAGCGCTCTGAACCAGATTTGAATATCTTGAAGGACTTGATCGATTCTAATTACGTTGTGTTCGATGTTTTACTTCAATTCCTAACCCATCAAGACCCAGTTGTGACTGCTGCAGCTGCTCAAGTCTATATTCGTCGTGCTTATCGTGCTTACACCATAGGAGATATTAGAGTTCACGAAGGTGTCACAGTTCCAATTGTTGAATGGAAATTCCAACTACCTTCAGCTGCGTTCTCCACCTTTCCAACTGTTAAATCTAAAATGGGTATGAACAGGGCTGTTTCTGTTTCAGATTTGTCATATGTTGCAAACAGTCAGTCATCTCCGTTAAGAGAAGGTATTTTGATGGCTGTGGATCATTTAGATGATGTTGATGAAATTTTGTCACAAAGTTTGGAAGTTATTCCTCGTCACCAATCTTCTTCTAACGGACCTGCTCCTGATCGTTCTGGTAGCTCCGCATCGTTGAGTAATGTTGCTAATGTTTGTGTTGCTTCTACAGAAGGTTTCGAATCTGAAGAGGAAATTTTGGTAAGGTTGAGAGAAATTTTGGATTTGAATAAGCAGGAATTAATCAATGCTTCTATCCGTCGTATCACATTTATGTTCGGTTTTAAAGATGGGTCTTATCCAAAGTATTATACTTTTAACGGTCCAAATTATAACGAAAATGAAACAATTCGTCACATTGAGCCGGCTTTGGCCTTCCAACTGGAATTAGGAAGATTGTCCAACTTCAACATTAAACCAATTTTCACTGATAATAGAAACATCCATGTCTACGAAGCTGTTAGTAAGACTTCTCCATTGGATAAGAGATTCTTTACAAGAGGTATTATTAGAACGGGTCATATCCGTGATGACATTTCTATTCAAGAATATCTGACTTCTGAAGCTAACAGATTGATGAGTGATATATTGGATAATTTAGAAGTCACCGACACTTCAAATTCTGATTTGAATCATATCTTCATCAACTTCATTGCGGTGTTTGATATCTCTCCAGAAGATGTCGAAGCCGCCTTCGGTGGTTTCTTAGAAAGATTTGGTAAGAGATTGTTGAGATTGCGTGTTTCTTCTGCCGAAATTAGAATCATCATCAAAGATCCTCAAACAGGTGCCCCAGTACCATTGCGTGCCTTGATCAATAACGTTTCTGGTTATGTTATCAAAACAGAAATGTACACCGAAGTCAAGAACGCAAAAGGTGAATGGGTATTTAAGTCTTTGGGTAAACCTGGATCCATGCATTTAAGACCTATTGCTACTCCTTACCCTGTTAAGGAATGGTTGCAACCAAAACGTTATAAGGCACACTTGATGGGTACCACATATGTCTATGACTTCCCAGAATTATTCCGCCAAGCATCGTCATCCCAATGGAAAAATTTCTCTGCAGATGTTAAGTTAACAGATGATTTCTTTATTTCCAACGAGTTGATTGAAGATGAAAACGGCGAATTAACTGAGGTGGAAAGAGAACCTGGTGCCAACGCTATTGGTATGGTTGCCTTTAAGATTACTGTAAAGACTCCTGAATATCCAAGAGGCCGTCAATTTGTTGTTGTTGCTAACGATATCACATTCAAGATCGGTTCCTTTGGTCCACAAGAAGACGAATTCTTCAATAAGGTTACTGAATATGCTAGAAAGCGTGGTATCCCAAGAATTTACTTGGCTGCAAACTCAGGTGCCAGAATTGGTATGGCTGAAGAGATTGTTCCACTATTTCAAGTTGCATGGAATGATGCTGCCAATCCGGACAAGGGCTTCCAATACTTATACTTAACAAGTGAAGGTATGGAAACTTTAAAGAAATTTGACAAAGAAAATTCTGTTCTCACTGAACGTACTGTTATAAACGGTGAAGAAAGATTTGTCATCAAGACAATTATTGGTTCTGAAGATGGGTTAGGTGTCGAATGTCTACGTGGATCTGGTTTAATTGCTGGTGCAACGTCAAGGGCTTACCACGATATCTTCACTATCACCTTAGTCACTTGTAGATCCGTCGGTATCGGTGCTTATTTGGTTCGTTTGGGTCAAAGAGCTATTCAGGTCGAAGGCCAGCCAATTATTTTAACTGGTGCTCCTGCAATCAACAAAATGCTGGGTAGAGAAGTTTATACTTCTAACTTACAATTGGGTGGTACTCAAATCATGTATAACAACGGTGTTTCACATTTGACTGCTGTTGACGATTTAGCTGGTGTAGAGAAGATTGTTGAATGGATGTCTTATGTTCCAGCCAAGCGTAATATGCCAGTTCCTATCTTGGAAACTAAAGACACATGGGATAGACCAGTTGATTTCACTCCAACTAATGATGAAACTTACGATGTAAGATGGATGATTGAAGGTCGTGAGACTGAAAGTGGATTTGAATATGGTTTGTTTGATAAAGGGTCTTTCTTTGAAACTTTGTCAGGATGGGCCAAAGGTGTTGTCGTTGGTAGAGCCCGTCTTGGTGGTATTCCACTGGGTGTTATTGGTGTTGAAACAAGAACTGTCGAGAACTTGATTCCTGCTGATCCAGCTAATCCAAATAGTGCTGAAACATTAATTCAAGAACCTGGTCAAGTTTGGCATCCAAACTCCGCCTTCAAGACTGCTCAAGCTATCAATGACTTTAACAACGGTGAACAATTGCCAATGATGATTTTGGCCAACTGGAGAGGTTTCTCTGGTGGTCAACGTGATATGTTCAACGAAGTCTTGAAGTATGGTTCGTTTATTGTTGACGCATTGGTGGATTACAAACAACCAATTATTATCTATATCCCACCTACCGGTGAACTAAGAGGTGGTTCATGGGTTGTTGTCGATCCAACTATCAACGCTGACCAAATGGAAATGTATGCCGACGTCAACGCTAGAGCTGGTGTTTTGGAACCACAAGGTATGGTTGGTATCAAGTTCCGTAGAGAAAAATTGCTGGACACCATGAACAGATTGGATGACAAGTACAGAGAATTGAGATCTCAATTATCCAACAAGAGTTTGGCTCCAGAAGTACATCAGCAAATATCCAAGCAATTAGCTGATCGTGAGAGAGAACTATTGCCAATTTACGGACAAATCAGTCTTCAATTTGCTGATTTGCACGATAGGTCTTCACGTATGGTGGCCAAGGGTGTTATTTCTAAGGAACTGGAATGGACCGAGGCACGTCGTTTCTTCTTCTGGAGATTGAGAAGAAGATTGAACGAAGAATATTTGATTAAAAGGTTGAGCCATCAGGTAGGCGAAGCATCAAGATTAGAAAAGATCGCAAGAATTAGATCGTGGTACCCTGCTTCAGTGGACCATGAAGATGATAGGCAAGTCGCAACATGGATTGAAGAAAACTACAAAACTTTGGACGATAAACTAAAGGGTTTGAAATTAGAGTCATTCGCTCAAGACTTAGCTAAAAAGATCAGAAGCGACCATGACAATGCTATTGATGGATTATCTGAAGTTATCAAGATGTTATCTACCGATGATAAAGAAAAATTGTTGAAGACTTTGAAATAA","protein_sequence":"MSEESLFESSPQKMEYEITNYSERHTELPGHFIGLNTVDKLEESPLRDFVKSHGGHTVISKILIANNGIAAVKEIRSVRKWAYETFGDDRTVQFVAMATPEDLEANAEYIRMADQYIEVPGGTNNNNYANVDLIVDIAERADVDAVWAGWGHASENPLLPEKLSQSKRKVIFIGPPGNAMRSLGDKISSTIVAQSAKVPCIPWSGTGVDTVHVDEKTGLVSVDDDIYQKGCCTSPEDGLQKAKRIGFPVMIKASEGGGGKGIRQVEREEDFIALYHQAANEIPGSPIFIMKLAGRARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPVTIAKAETFHEMEKAAVRLGKLVGYVSAGTVEYLYSHDDGKFYFLELNPRLQVEHPTTEMVSGVNLPAAQLQIAMGIPMHRISDIRTLYGMNPHSASEIDFEFKTQDATKKQRRPIPKGHCTACRITSEDPNDGFKPSGGTLHELNFRSSSNVWGYFSVGNNGNIHSFSDSQFGHIFAFGENRQASRKHMVVALKELSIRGDFRTTVEYLIKLLETEDFEDNTITTGWLDDLITHKMTAEKPDPTLAVICGAATKAFLASEEARHKYIESLQKGQVLSKDLLQTMFPVDFIHEGKRYKFTVAKSGNDRYTLFINGSKCDIILRQLSDGGLLIAIGGKSHTIYWKEEVAATRLSVDSMTTLLEVENDPTQLRTPSPGKLVKFLVENGEHIIKGQPYAEIEVMKMQMPLVSQENGIVQLLKQPGSTIVAGDIMAIMTLDDPSKVKHALPFEGMLPDFGSPVIEGTKPAYKFKSLVSTLENILKGYDNQVIMNASLQQLIEVLRNPKLPYSEWKLHISALHSRLPAKLDEQMEELVARSLRRGAVFPARQLSKLIDMAVKNPEYNPDKLLGAVVEPLADIAHKYSNGLEAHEHSIFVHFLEEYYEVEKLFNGPNVREENIILKLRDENPKDLDKVALTVLSHSKVSAKNNLILAILKHYQPLCKLSSKVSAIFSTPLQHIVELESKATAKVALQAREILIQGALPSVKERTEQIEHILKSSVVKVAYGSSNPKRSEPDLNILKDLIDSNYVVFDVLLQFLTHQDPVVTAAAAQVYIRRAYRAYTIGDIRVHEGVTVPIVEWKFQLPSAAFSTFPTVKSKMGMNRAVSVSDLSYVANSQSSPLREGILMAVDHLDDVDEILSQSLEVIPRHQSSSNGPAPDRSGSSASLSNVANVCVASTEGFESEEEILVRLREILDLNKQELINASIRRITFMFGFKDGSYPKYYTFNGPNYNENETIRHIEPALAFQLELGRLSNFNIKPIFTDNRNIHVYEAVSKTSPLDKRFFTRGIIRTGHIRDDISIQEYLTSEANRLMSDILDNLEVTDTSNSDLNHIFINFIAVFDISPEDVEAAFGGFLERFGKRLLRLRVSSAEIRIIIKDPQTGAPVPLRALINNVSGYVIKTEMYTEVKNAKGEWVFKSLGKPGSMHLRPIATPYPVKEWLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNELIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITFKIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGMAEEIVPLFQVAWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERTVINGEERFVIKTIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVRLGQRAIQVEGQPIILTGAPAINKMLGREVYTSNLQLGGTQIMYNNGVSHLTAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETYDVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGVIGVETRTVENLIPADPANPNSAETLIQEPGQVWHPNSAFKTAQAINDFNNGEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPPTGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPQGMVGIKFRREKLLDTMNRLDDKYRELRSQLSNKSLAPEVHQQISKQLADRERELLPIYGQISLQFADLHDRSSRMVAKGVISKELEWTEARRFFFWRLRRRLNEEYLIKRLSHQVGEASRLEKIARIRSWYPASVDHEDDRQVATWIEENYKTLDDKLKGLKLESFAQDLAKKIRSDHDNAIDGLSEVIKMLSTDDKEKLLKTLK"},{"created_at":"2011-05-27T17:07:41.000Z","updated_at":"2011-05-29T05:06:52.000Z","name":"Malonyl CoA-acyl carrier protein transacylase, mitochondrial","uniprot_id":"Q12283","uniprot_name":"FABD_YEAST","enzyme":true,"transporter":false,"gene_name":"MCT1","num_residues":360,"molecular_weight":"40706.89844","theoretical_pi":"6.92","general_function":"Involved in transferase activity","specific_function":"Involved in biosynthesis of fatty acids in mitochondria","reactions":[{"id":2402,"direction":"\u003e","locations":"Mitochondrion","altext":"Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"MCT1","chromosome_location":"chromosome 15","locus":"YOR221C","synonyms":["MCT","Malonyl-CoA:ACP transferase"],"enzyme_classes":["2.3.1.39"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[],"pathways":[{"name":"Fatty acid biosynthesis","kegg_map_id":"00061"}],"gene_sequence":"AGCACTAGAGCATAACTAATACTATAAATTAGACAAAGCAGAAAAAGGGAAAAAGGTTCATGCTATGATAATGTAAAGAATATGCGTAGAGATATCTATATATCCATTTATACGTTTATATACTTGCGTGTTTACTTTGTATGGCATAATAACATGTATGTTTGCATTAGGGATTTGTTTTAGTGTATCCAAGAGCGATTAGTATAGAAGGAATGTATGTATGTGTATACGATATTTATATAAAGGGAAGTTGGCTAATTTTTTGCACACTTTCGTCCTCTTTCCATTTTCAATGAATGCGTAGAAGCACAGACTGGGAGTGGAGAGAGTTCGCAGTTTTGATCTCTTTCTCAATCTTTGTTCTCCTCTGCCGCCTTGTGATAAGCGTCTATAGTTGCTAAAGAGGTGTATTCTATAGTGTCCACTTGGGGACAATTTCTCCGAATAAGGTTATAAATCACATTGCCCGGGCCAAAGCAAATACTCTTATCAATTTCCACTGGGGTTCCAGAGTTTATGGTATCATAACACATGGTGAATTGCACAGTCCTGCTTGAACACTTAACGAATCTATCTAGGGCATGATGAATATAGTAAGATATATTACCATCTAAGTTAGCTATTATTGGATGGTTCAACTCCATCAACGTGTGAGTTCCGTTTTTCTTTAATATATCCCAAATGTAGTCATAGAGTGGTTCCTGAACGGGCCTCAACACAGTGCTATTATGGAAGGGGATGTTGTATGGGTTAGTTAATTCTGTAATTCTTAAACGCGGGAACCTTAAGTTCAATTCTGTTCTTAAGGACTCTAAATCATCAACCAGACCGGTGACTACACATTGCTTTACTGAATTTGCATTTGCTACAGAAATGGTATTTTGTGAAGATGATAATAAATTAGGGGAATTTAGTAGTTTTTGCACTTCTTGCGGTAAATCTGTGGCCCTCGGAGAAGAGAGTGCCCACATTTCAAATTTGTTGGATCTGTTGATATTGTGGGCTACTAAGTACTTTTCAGTAGATGTTACCATTAACTTATTTCTAAAATTAGCAATATCAAAAAGATCCTTTAACGAAAACAGTGAATTAACACTCAGACATGTTAACTCGCCTAGCGAGTGACCCAAAAGGTAACATTGTTCATTGTCTTTCTTGTCGGGGGAATCGATCTTAGTCATATTTTTTGGTGCTTGATCTTGAGGATCAGAAGGATTCGAGAGTATCTGGTACAATTGATAGAAAAGGTTGGAGCAGACTGCAATGCTTCCGGGGCTGGAAGGGTTCTGGAAGATGTACTGCAATAGATCATTTGATTCCTTGCCGTTCTGACTCAGTATTGTTTGGAATTCTCTTGATTTGTTTCTTATTATCGCTTTTAATATCGAAATGGAGATGGAGGTCCCTTGACCTGGGAAGGTTAGTAGCTTCATACAAACGCTTATATATGTGTACCACGATCAGAAAAGTGCAAAACGCTTTGTTACTACCCTCAGTGTACGTTATTGAATAGTTCTAATATGCAGCAAGTTACTGGTAAGCTTTGTTTTACCCTTGAGTTCGATACTCAGTTTACTTCCTCCATCGGAGGTTGAAATGCGCCTTGTCATACGGCCAAAAAATGCCATGTAAGAAGATGACACTTTCTGCATTTTGAGTATATTTAAGGGCCTATAATTTTCTTCCAACTTTCTCAAGACAAGCATATTGTGTACTTTCGGTTTAGCAAGCCTTTTTACTTCGTTAACACAAGGCGATGCTAACGTGTGTTTACTGTTTTAGAAGATCGGCATTTATCAAATGTAAGGACAATGAGACATGGTTGACCAATTAGTTCTTCTCAGATAGGAGTTCTAGTTCTTCTGCATACTACTTAGTCCTCTTCTGTCGTTGACATTCAATTGCTTGTGCATTTCTAACATGAAATAGTGGTACTACGAATGCTATTATTCTATGCCAGGCAAATTCCTCTGGAACTTTTTTTTTTTCAGTTTTTTCGTGGTGAGCTTTTTTTGCCTGTCTATCTCGAAAGATCTTGTTGTTGATGACTCAGTGCAGTCGCGATCACTTTCGACTCGACATGCATTTGCAAGTAATTCTGTTATAAAACGTTCTCTTCGTTTTTTCAGTCTGAAGCTCTTCTGCACTTTTTTACTGGGTTAGATTCTATATAGTCAAGTAATTCGAGGTAGCATCAAAGTAAT","protein_sequence":"MKLLTFPGQGTSISISILKAIIRNKSREFQTILSQNGKESNDLLQYIFQNPSSPGSIAVCSNLFYQLYQILSNPSDPQDQAPKNMTKIDSPDKKDNEQCYLLGHSLGELTCLSVNSLFSLKDLFDIANFRNKLMVTSTEKYLVAHNINRSNKFEMWALSSPRATDLPQEVQKLLNSPNLLSSSQNTISVANANSVKQCVVTGLVDDLESLRTELNLRFPRLRITELTNPYNIPFHNSTVLRPVQEPLYDYIWDILKKNGTHTLMELNHPIIANLDGNISYYIHHALDRFVKCSSRTVQFTMCYDTINSGTPVEIDKSICFGPGNVIYNLIRRNCPQVDTIEYTSLATIDAYHKAAEENKD"}]}