{"ymdb_id":"YMDB00517","created_at":"2011-05-29T18:25:48.000Z","updated_at":"2016-09-08T18:35:34.000Z","name":"10-Formyltetrahydrofolic acid","cas":"2800-34-2","state":"Solid","melting_point":null,"description":"10-Formyltetrahydrofolate is an intermediate in the tetrahydrofolate salvage pathway. Tetrahydrofolate (vitamin B9) and its derivatives, commonly termed folates, are essential cofactors that facilitate the transfer of one-carbon units from donor molecules into important biosynthetic pathways leading to methionine, purine, and pyrimidine biosynthesis. Folates also mediate the interconversion of serine and glycine, and play a role in histidine catabolism. [Biocyc PWY-6613]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cytoplasm, Mitochondrion","synthesis_reference":null,"chebi_id":"15637","hmdb_id":"HMDB00972","kegg_id":"C00234","pubchem_id":"122347","cs_id":"23499025","foodb_id":null,"wikipedia_link":"10-formyl-tetrahydrofolate","biocyc_id":"10-FORMYL-THF","iupac":"(2S)-2-{[4-(N-{[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}formamido)phenyl]formamido}pentanedioic acid","traditional_iupac":"10-formyltetrahydrofolic acid","logp":"-3.371732827151703","pka":"3.597415477616566","alogps_solubility":"3.49e-01 g/l","alogps_logp":"-1.79","alogps_logs":"-3.13","acceptor_count":"11","donor_count":"7","rotatable_bond_count":"9","polar_surface_area":"215.55","refractivity":"124.88119999999996","polarizability":"46.63277487497841","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"4.472180456626537","pka_strongest_acidic":"2.8185105858286112","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["(6S)-10-HCO-H4folate","10-Formyl-(6RS)-tetrahydrofolic acid","10-formyl-H4PteGlu1","10-formyl-tetrahydrofolate","10-formyl-thf","10-formyltetrahydrofolate","10-formyltetrahydrofolic acid","10-formyltetrahydropteroylglutamate","10-formyltetrahydropteroylglutamic acid","10-fthf","N-(10-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid","N10-Formyl-5,6,7,8-tetrahydrofolate","N10-Formyl-5,6,7,8-tetrahydrofolic acid","N10-formyl-H4F","N10-formyl-tetrahydrofolate","N10-formyl-THF","N10-Formyltetrahydrofolate","N10-Formyltetrahydrofolic acid","N10-Formyltetrahydropteroylglutamate"],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null},{"name":"One Carbon Pool by Folate I","kegg_map_id":null},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":8706696,"citation":"Briza, P., Kalchhauser, H., Pittenauer, E., Allmaier, G., Breitenbach, M. (1996). \"N,N'-Bisformyl dityrosine is an in vivo precursor of the yeast ascospore wall.\" Eur J Biochem 239:124-131."}],"proteins":[{"created_at":"2011-05-24T19:22:02.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"Phosphoribosylglycinamide formyltransferase","uniprot_id":"P04161","uniprot_name":"PUR3_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE8","num_residues":214,"molecular_weight":"23540.0","theoretical_pi":"6.39","general_function":"Involved in hydroxymethyl-, formyl- and related transferase activity","specific_function":"10-formyltetrahydrofolate + N(1)-(5-phospho-D- ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide","reactions":[{"id":1890,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2249,"direction":"\u003e","locations":null,"altext":"10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.","export":false,"pw_reaction_id":null,"source":null},{"id":4151,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006449","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M36585","genbank_protein_id":"171015","gene_card_id":"ADE8","chromosome_location":"chromosome 4","locus":"YDR408C","synonyms":["5'-phosphoribosylglycinamide transformylase","GAR transformylase","GART"],"enzyme_classes":["2.1.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Function","description":" phosphoribosylglycinamide formyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" IMP biosynthetic process"},{"category":"Process","description":" 'de novo' IMP biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Formyl_trans_N","identifier":"PF00551"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGGCCAGAATTGTCGTATTAATTTCGGGCTCAGGTTCCAACTTGCAAGCCTTGATCGATGCCCAAAAGCAGGGCCAATTAGGCGAGGATGCTCATATTGTCTCTGTCATATCTTCCAGCAAGAAGGCATACGGGTTAACTAGGGCAGCGGACAATAATATCCCCACAAAGGTTTGTTCGCTATACCCATATACAAAGGGTATTGCGAAGGAGGACAAAGCCGCAAGGGCCAAGGCAAGATCCCAGTTTGAGAACGACCTCGCAAAACTAGTGCTCGAGGAAAAGCCTGACGTTATCATCTGCGCGGGCTGGTTATTGATCCTTGGATCTACTTTCTTGAGCCAACTGCAATCTGTGCCGATATTAAATCTGCATCCAGCGCTACCAGGTTGTTTCGATGGTACCACACACGCAATTGAAATGGCATGGCGCAAATGTCAGGACGAGAACAAGCCTCTGACGGCCGGATGCATGGTGCACTATGTCATCGAGGAGGTCGACAAGGGTGAGCCATTGGTGGTAAAAAAGCTAGAAATCATACCTGGCGAAGAAACACTAGAGCAGTACGAGCAAAGGGTACACGATGCTGAGCACATCGCGATTGTAGAAGCTACATATAAGGTTTTACAGCAGCTTCACAAATAA","protein_sequence":"MARIVVLISGSGSNLQALIDAQKQGQLGEDAHIVSVISSSKKAYGLTRAADNNIPTKVCSLYPYTKGIAKEDKAARAKARSQFENDLAKLVLEEKPDVIICAGWLLILGSTFLSQLQSVPILNLHPALPGCFDGTTHAIEMAWRKCQDENKPLTAGCMVHYVIEEVDKGEPLVVKKLEIIPGEETLEQYEQRVHDAEHIAIVEATYKVLQQLHK"},{"created_at":"2011-05-26T17:51:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"C-1-tetrahydrofolate synthase, mitochondrial","uniprot_id":"P09440","uniprot_name":"C1TM_YEAST","enzyme":true,"transporter":false,"gene_name":"MIS1","num_residues":975,"molecular_weight":"106216.0","theoretical_pi":"9.02","general_function":"Involved in formate-tetrahydrofolate ligase activity","specific_function":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH","reactions":[{"id":1548,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1727,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1733,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2488,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2489,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":2490,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":3849,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006370","source":"Smpdb"},{"id":3850,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006371","source":"Smpdb"},{"id":3851,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006372","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"J03724","genbank_protein_id":"171953","gene_card_id":"MIS1","chromosome_location":"chromosome 2","locus":"YBR084W","synonyms":["C1-THF synthase","Methylenetetrahydrofolate dehydrogenase","Methenyltetrahydrofolate cyclohydrolase","Formyltetrahydrofolate synthetase"],"enzyme_classes":["1.5.1.5","3.5.4.9","6.3.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" formate-tetrahydrofolate ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FTHFS","identifier":"PF01268"},{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTTGTCGAGACTATCTTTATTGAGTAACTCGAGGGCGTTCCAACAGGCCAGATGGCGCATTTACCGCTTAAAAGTTTCGCCAACTGTGCATGCTTCTCAATACCATATTCTTTCTGGTAGGAAACTTGCTCAATCTATTCGAGAAAAAGCCAATGATGAGATACAAGCCATTAAGCTTAAGCATCCTAATTTCAAGCCTACCTTGAAAATCATTCAAGTCGGGGCCAGACCAGACTCATCTACGTACGTGAGGATGAAATTGAAAGCTTCAAAGGACAGCAATGTAGACTGTATCATAGAGAAGTTACCAGCAGAAATCACTGAAGTTGAGCTTTTGAAGAAAATTAGTGACATCAATGATGATGACTCTATCCATGGGTTGCTAATTCAACTACCTCTACCGCGTCACTTGGATGAAACCACGATTACAAACGCTGTGGACTTTAAAAAGGACGTTGATGGGTTCCACAGATATAATGCTGGTGAATTGGCTAAAAAAGGAGGGAAACCATACTTCATACCATGTACTCCTTATGGTTGCATGAAATTACTTGAAGAAGCTCATGTTAAGTTAGATGGTAAGAACGCCGTCGTGTTAGGCAGATCAAGTATCGTCGGAAATCCAATTGCTTCGTTGTTGAAAAATGCGAATGCCACTGTTACTGTCTGTCATAGTCATACAAGGAACATTGCAGAAGTGGTCTCCCAAGCTGATATAGTTATCGCAGCTTGCGGTATTCCTCAATACGTTAAATCAGACTGGATTAAAGAAGGCGCCGTGGTTATTGATGTAGGTATCAACTACGTACCTGATATCAGTAAGAAAAGTGGGCAAAAATTAGTTGGTGATGTTGATTTTGATTCTGTAAAGGAAAAGACATCTTATATTACCCCTGTTCCTGGTGGAGTGGGTCCAATGACTGTCGCTATGCTTGTTTCCAATGTACTATTAGCTGCTAAAAGGCAATTCGTGGAATCTGAAAAGCTTCCAGTTATCAAACCTCTTCCATTACACTTAGAAAGTCCAGTGCCTTCAGATATTGATATATCAAGAGCTCAGAGTCCTAAGCATATCAAGCAAGTTGCCGAGGAGTTGGGAATCCACTCTCACGAATTAGAATTATACGGCCACTATAAGGCAAAAATTTCTCCAAATATTTTTAAAAGATTAGAATCTAGAGAAAACGGTAAGTACGTCCTTGTTGCAGGTATTACTCCGACTCCATTGGGTGAAGGTAAATCCACTACGACTATGGGGTTGGTGCAGGCTTTATCCGCTCATTTAGGGAAACCATCCATCGCGAACGTTAGACAACCATCTCTTGGCCCAACCCTGGGTGTCAAAGGTGGTGCTGCTGGTGGTGGTTATGCCCAAGTTATTCCTATGGACGAGTTCAATTTACATTTGACCGGGGATATTCATGCTATCAGCGCTGCGAACAATCTTCTTGCAGCAGCTATCGACACTAGAATGTTCCATGAAGCCACTCAGAAGAATGATAGTACATTTTACAAGAGACTAGTTCCAAGAAAAAAAGGCATCAGAAAGTTTACCCCATCCATGCAGAGAAGGCTTAAAAGATTGGATATTGAAAAAGAAGACCCTGATGCTTTAACACCTGAAGAAGTCAAAAGATTTGCTAGATTGAACATAAATCCCGATACTATCACTATCAGAAGAGTTGTCGACATCAATGACAGGATGTTAAGACAAATTACCATTGGCGAAGCCGCTACGGAGAAGGGTTTTACAAGGACCACTGGATTCGATATCACTGTTGCCTCTGAATTAATGGCCATTTTAGCTCTATCTAAAAGCTTACACGAGATGAAGGAACGTATTGGACGCATGGTTATTGGTGCTGATTATGATAACAAACCAGTAACAGTAGAAGATATTGGCTGTACCGGTGCTCTGACTGCATTATTACGTGACGCTATAAAGCCTAACTTAATGCAAACTTTGGAAGGGACCCCCGTAATGGTTCACGCTGGTCCTTTCGCCAACATCTCCATCGGCGCATCATCAGTAATTGCAGACTTAATGGCATTGAAGCTTGTTGGTTCAGAAAAGAACCCGTTAAATGACAAGAACATCCATGAACCTGGTTATGTAGTTACTGAAGCAGGATTCGATTTTGCCATGGGTGGTGAAAGATTCTTTGATATCAAATGTCGTTCCTCTGGATTGGTGCCAGATGCAGTTGTCTTAGTCGCAACCGTAAGAGCTTTGAAATCTCATGGAGGTGCTCCAAATGTTAAGCCCGGACAATCATTACCAAAAGAATACACAGAGGAAAACATCGATTTTGTTGCCAAGGGTGTTAGTAATTTGGTTAAGCAGATTGAAAACATCAAAACGTTTGGAATACCAGTCGTTGTAGCAATCAACAGATTTGAAACAGACTCACAGGCAGAGATTGAGGTAATCAAGAAAGCAGCCTTGAATGCTGGCGCATCTCATGCCGTTACTTCTAATCACTGGATGGAAGGTGGTAAAGGTGCAGTAGAATTAGCACATGCTGTGGTAGATGCAACGAAAGAACCAAAGAACTTTAACTTTTTGTACGACGTCAATAGCTCCATCGAGGACAAGCTTACCAGCATCGTCCAAAAAATGTATGGTGGGGCAAAAATCGAAGTATCACCAGAAGCCCAAAAAAAGATAGACACCTACAAAAAACAAGGCTTCGGTAATCTTCCCATCTGTATTGCTAAGACACAATATTCATTATCCCATGATCCATCATTAAAGGGTGTTCCTAGAGGTTTTACGTTCCCCATCAGGGATGTGAGAGCTTCAATAGGTGCAGGTTATTTATACGCTTTGGCTGCAGAAATTCAAACCATACCGGGTCTATCGACATATGCTGGTTACATGGCAGTAGAAGTCGACGACGACGGTGAAATTGAAGGTCTATTTTAA","protein_sequence":"MLSRLSLLSNSRAFQQARWRIYRLKVSPTVHASQYHILSGRKLAQSIREKANDEIQAIKLKHPNFKPTLKIIQVGARPDSSTYVRMKLKASKDSNVDCIIEKLPAEITEVELLKKISDINDDDSIHGLLIQLPLPRHLDETTITNAVDFKKDVDGFHRYNAGELAKKGGKPYFIPCTPYGCMKLLEEAHVKLDGKNAVVLGRSSIVGNPIASLLKNANATVTVCHSHTRNIAEVVSQADIVIAACGIPQYVKSDWIKEGAVVIDVGINYVPDISKKSGQKLVGDVDFDSVKEKTSYITPVPGGVGPMTVAMLVSNVLLAAKRQFVESEKLPVIKPLPLHLESPVPSDIDISRAQSPKHIKQVAEELGIHSHELELYGHYKAKISPNIFKRLESRENGKYVLVAGITPTPLGEGKSTTTMGLVQALSAHLGKPSIANVRQPSLGPTLGVKGGAAGGGYAQVIPMDEFNLHLTGDIHAISAANNLLAAAIDTRMFHEATQKNDSTFYKRLVPRKKGIRKFTPSMQRRLKRLDIEKEDPDALTPEEVKRFARLNINPDTITIRRVVDINDRMLRQITIGEAATEKGFTRTTGFDITVASELMAILALSKSLHEMKERIGRMVIGADYDNKPVTVEDIGCTGALTALLRDAIKPNLMQTLEGTPVMVHAGPFANISIGASSVIADLMALKLVGSEKNPLNDKNIHEPGYVVTEAGFDFAMGGERFFDIKCRSSGLVPDAVVLVATVRALKSHGGAPNVKPGQSLPKEYTEENIDFVAKGVSNLVKQIENIKTFGIPVVVAINRFETDSQAEIEVIKKAALNAGASHAVTSNHWMEGGKGAVELAHAVVDATKEPKNFNFLYDVNSSIEDKLTSIVQKMYGGAKIEVSPEAQKKIDTYKKQGFGNLPICIAKTQYSLSHDPSLKGVPRGFTFPIRDVRASIGAGYLYALAAEIQTIPGLSTYAGYMAVEVDDDGEIEGLF"},{"created_at":"2011-05-26T17:52:10.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Bifunctional purine biosynthesis protein ADE17","uniprot_id":"P38009","uniprot_name":"PUR92_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE17","num_residues":592,"molecular_weight":"65262.60156","theoretical_pi":"6.52","general_function":"Involved in IMP cyclohydrolase activity","specific_function":"10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide","reactions":[{"id":1655,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1886,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2491,"direction":"\u003e","locations":"Cytoplasmic","altext":"10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null},{"id":2492,"direction":"\u003e","locations":"Cytoplasmic","altext":"IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null},{"id":14239,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006682","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"Z49273","genbank_protein_id":"809579","gene_card_id":"ADE17","chromosome_location":"chromosome 13","locus":"YMR120C","synonyms":["Phosphoribosylaminoimidazolecarboxamide formyltransferase","5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase","AICAR transformylase","IMP cyclohydrolase","ATIC","IMP synthase","Inosinicase"],"enzyme_classes":["2.1.2.3","3.5.4.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" phosphoribosylaminoimidazolecarboxamide formyltransferase activity"},{"category":"Function","description":" cyclohydrolase activity"},{"category":"Function","description":" IMP cyclohydrolase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" IMP biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"MGS","identifier":"PF02142"},{"name":"AICARFT_IMPCHas","identifier":"PF01808"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"One Carbon Pool by Folate I","kegg_map_id":null}],"gene_sequence":"ATGGCCAATTACACAAAAACCGCAATCCTATCCGTCTATGACAAGACAGGTCTACTTGATTTAGCCAGAGGCCTCATCGAGAAGAACGTTCGTATTCTCGCCTCCGGTGGTACTGCTCGTATGATTCGTGACGCTGGTTTTCCAATCGAAGACGTTTCTGCTATCACACATGCCCCAGAAATGTTGGGAGGTAGAGTGAAAACTTTACATCCTGCCGTTCATGGTGGTATCCTTGCTAGGGACATCGATAGCGATGAGAAAGACTTGAAGGAACAGCACATTGAAAAAGTCGATTATGTCGTTTGTAACCTATACCCATTCAAAGAAACTGTTGCTAAGGTGGGTGTGACTATTCCAGAAGCAGTAGAAGAAATTGATATTGGTGGTGTTACTCTATTAAGAGCAGCTGCTAAGAACCATGCTAGAGTCACTATTTTATCTGATCCAAAGGACTACTCCGAATTTTTAAGTGAATTATCCAGTAATGGTGAAATCTCTCAAGATTTGAGAAACAGATTGGCATTAAAGGCTTTCGAACACACTGCCGATTATGATGCTGCAATTTCAGATTTCTTCAGGAAACAATACTCTGAAGGTCAAGCTCAAATTACTCTACGTTATGGTGCCAATCCACACCAAAAGCCGGCTCAAGCTTACGTCAGTCAACAAGACAGTTTACCTTTCAAAGTCCTATGTGGTTCACCAGGTTACATTAATTTGTTGGATGCTCTAAATTCCTGGCCCCTGGTTAAGGAATTATCCGCCTCGTTGAATTTACCAGCAGCAGCATCGTTCAAGCATGTATCACCAGCTGGTGCCGCTGTGGGTATCCCATTGTCTGATGTTGAAAAGCAAGTTTATTTTGTTGCCGACATTGAAAACTTATCTCCCCTGGCATGTGCCTATGCTAGGGCCCGTGGTGCTGATAGAATGTCTTCCTTTGGTGATTGGATTGCTCTTTCCAACATAGTTGATGTTCCAACAGCTAAGATCATATCTAGAGAAGTTTCTGATGGTGTTATTGCCCCAGGTTATGAGCCTGAGGCGTTGGCCATTCTATCCAAGAAGAAGGGAGGTAAGTACTGCATATTACAAATTGATCCAAACTATGTTCCAGAAGCTGTCGAAAGAAGACAAGTATACGGTGTGACTTTGGAACAAAAGAGAAACGATGCCATAATCAATCAATCAACTTTCAAAGAAATTGTTTCTCAAAATAAAAATCTCACTGAACAAGCCATAATTGATTTAACGGTTGCCACCATTGCTATTAAATATACTCAATCTAATTCCGTATGTTATGCTAGAAATGGTATGGTTGTCGGATTGGGTGCAGGTCAACAATCTAGAATCCATTGTACAAGATTAGCTGGTGATAAGGCTGATAATTGGTGGTTCAGACAACACCCTAGAGTTTTGGAGATTAAATGGGCTAAAGGCGTCAAGAGACCAGAAAAATCTAATGCTATCGATTTATTCGTAACCGGCCAAATTCCAACAGAAGAACCAGAATTGTCTGAATACCAATCGAAGTTCGAGGAGATTCCAAAACCATTTACTCCAGAAGAAAGAAAGGAATGGTTGAGTAAATTAACCAACGTTTCTTTGTCATCGGATGCATTTTTCCCATTCCCAGACAATGTTTACAGAGCAGTTAAATCCGGTGTCAAATACATTGCCGCTCCATCTGGTTCTGTCATGGACAAGGTTGTATTTTCAGCTGCCGATTCATTCGATTTGGTTTACGTAGAGAACCCAATCCGTTTGTTCCACCATTAG","protein_sequence":"MANYTKTAILSVYDKTGLLDLARGLIEKNVRILASGGTARMIRDAGFPIEDVSAITHAPEMLGGRVKTLHPAVHGGILARDIDSDEKDLKEQHIEKVDYVVCNLYPFKETVAKVGVTIPEAVEEIDIGGVTLLRAAAKNHARVTILSDPKDYSEFLSELSSNGEISQDLRNRLALKAFEHTADYDAAISDFFRKQYSEGQAQITLRYGANPHQKPAQAYVSQQDSLPFKVLCGSPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGIPLSDVEKQVYFVADIENLSPLACAYARARGADRMSSFGDWIALSNIVDVPTAKIISREVSDGVIAPGYEPEALAILSKKKGGKYCILQIDPNYVPEAVERRQVYGVTLEQKRNDAIINQSTFKEIVSQNKNLTEQAIIDLTVATIAIKYTQSNSVCYARNGMVVGLGAGQQSRIHCTRLAGDKADNWWFRQHPRVLEIKWAKGVKRPEKSNAIDLFVTGQIPTEEPELSEYQSKFEEIPKPFTPEERKEWLSKLTNVSLSSDAFFPFPDNVYRAVKSGVKYIAAPSGSVMDKVVFSAADSFDLVYVENPIRLFHH"},{"created_at":"2011-05-26T17:52:41.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Bifunctional purine biosynthesis protein ADE16","uniprot_id":"P54113","uniprot_name":"PUR91_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE16","num_residues":591,"molecular_weight":"65281.80078","theoretical_pi":"6.52","general_function":"Involved in IMP cyclohydrolase activity","specific_function":"10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide","reactions":[{"id":1655,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1886,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2491,"direction":"\u003e","locations":"Cytoplasmic","altext":"10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null},{"id":2492,"direction":"\u003e","locations":"Cytoplasmic","altext":"IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"U62402","genbank_protein_id":"1480728","gene_card_id":"ADE16","chromosome_location":"chromosome 12","locus":"YLR028C","synonyms":["Phosphoribosylaminoimidazolecarboxamide formyltransferase","5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase","AICAR transformylase","IMP cyclohydrolase","ATIC","IMP synthase","Inosinicase"],"enzyme_classes":["2.1.2.3","3.5.4.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" phosphoribosylaminoimidazolecarboxamide formyltransferase activity"},{"category":"Function","description":" cyclohydrolase activity"},{"category":"Function","description":" IMP cyclohydrolase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" IMP biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"MGS","identifier":"PF02142"},{"name":"AICARFT_IMPCHas","identifier":"PF01808"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGGGCAAATATACCAAGACTGCGATCTTGTCAGTTTATGATAAGACAGGTTTATTAGACTTAGCCAAGGGATTGGTAGAGAACAATGTTCGTATCCTAGCATCCGGTGGTACGGCCAACATGGTCAGAGAAGCTGGTTTTCCGGTCGACGATGTTTCTTCAATTACGCATGCACCAGAAATGCTAGGGGGTAGAGTCAAGACTCTTCACCCTGCTGTGCATGCAGGTATTCTTGCCAGAAATTTAGAGGGCGATGAAAAAGATTTAAAAGAGCAGCACATTGATAAGGTGGATTTTGTTGTATGTAATCTATATCCGTTCAAAGAAACTGTGGCTAAAATTGGTGTTACAGTTCAAGAAGCTGTAGAGGAGATCGACATTGGCGGTGTGACTTTGTTGAGAGCAGCCGCAAAGAACCATTCCAGAGTGACTATTCTTTCAGACCCTAATGACTATTCTATCTTTCTGCAAGACCTGTCTAAGGACGGTGAAATTTCTCAGGATTTAAGAAATAGATTTGCACTTAAGGCGTTTGAACATACGGCCGATTATGATGCGGCCATTTCTGACTTTTTCAGGAAACAGTACTCCGAAGGGAAAGCCCAATTACCGCTAAGATATGGTTGTAATCCCCACCAAAGACCTGCACAAGCTTATATCACTCAGCAGGAGGAGTTGCCCTTCAAAGTGCTCTGCGGTACACCAGGATATATAAATCTTTTGGATGCCTTGAACTCATGGCCCTTAGTGAAAGAGTTATCTGCATCATTGAACTTGCCTGCGGCAGCATCGTTCAAGCACGTTTCTCCAGCAGGTGCTGCTGTGGGACTTCCATTATCCGATGTGGAAAGACAAGTTTATTTTGTGAATGATATGGAGGATTTATCACCATTGGCATGCGCATACGCTAGGGCCCGTGGTGCAGATAGGATGTCATCCTTTGGTGATTTCATTGCATTGTCCAATATTGTAGATGTCGCCACTGCAAAAATCATCTCTAAAGAAGTTTCCGATGGTGTTATTGCTCCAGGGTATGAACCAGAGGCATTGAATATACTATCTAAGAAGAAAAACGGAAAATACTGTATTTTACAAATCGATCCAAACTATGTTCCTGGCCAAATGGAATCCCGAGAGGTTTTTGGCGTAACGTTACAACAGAAGAGAAACGATGCGATCATAAACCAATCCACTTTCAAAGAAATTGTCTCCAAAAACAAAGCACTCACCGAGCAAGCCGTTATCGATCTAACTGTTGCTACGCTGGTTTTAAAATACACACAATCAAATTCTGTTTGCTACGCAAAGAATGGTATGGTTGTGGGGCTTGGGGCCGGCCAACAATCGCGTATACACTGTACCAGATTAGCTGGTGACAAGACGGACAACTGGTGGTTGAGACAACATCCAAAGGTTTTGAACATGAAGTGGGCCAAGGGAATTAAGAGAGCGGACAAGTCGAATGCGATTGATCTTTTTGTTACAGGGCAAAGAATAGAAGGCCCGGAAAAGGTGGATTACGAAAGCAAATTTGAAGAAGTCCCTGAACCTTTCACCAAAGAAGAAAGACTAGAATGGTTAAGCAAATTAAACAATGTATCGTTATCATCCGATGCGTTCTTTCCCTTCCCAGACAACGTTTATAGAGCTGTGCAGTCTGGTGTAAAGTTCATCACGGCTCCTTCGGGGTCTGTCATGGACAAAGTTGTCTTCCAAGCGGCGGATTCATTTGATATCGTCTACGTGGAGAACCCAATTCGTTTATTCCACCACTAA","protein_sequence":"MGKYTKTAILSVYDKTGLLDLAKGLVENNVRILASGGTANMVREAGFPVDDVSSITHAPEMLGGRVKTLHPAVHAGILARNLEGDEKDLKEQHIDKVDFVVCNLYPFKETVAKIGVTVQEAVEEIDIGGVTLLRAAAKNHSRVTILSDPNDYSIFLQDLSKDGEISQDLRNRFALKAFEHTADYDAAISDFFRKQYSEGKAQLPLRYGCNPHQRPAQAYITQQEELPFKVLCGTPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGLPLSDVERQVYFVNDMEDLSPLACAYARARGADRMSSFGDFIALSNIVDVATAKIISKEVSDGVIAPGYEPEALNILSKKKNGKYCILQIDPNYVPGQMESREVFGVTLQQKRNDAIINQSTFKEIVSKNKALTEQAVIDLTVATLVLKYTQSNSVCYAKNGMVVGLGAGQQSRIHCTRLAGDKTDNWWLRQHPKVLNMKWAKGIKRADKSNAIDLFVTGQRIEGPEKVDYESKFEEVPEPFTKEERLEWLSKLNNVSLSSDAFFPFPDNVYRAVQSGVKFITAPSGSVMDKVVFQAADSFDIVYVENPIRLFHH"},{"created_at":"2011-05-26T17:53:12.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Methionyl-tRNA formyltransferase, mitochondrial","uniprot_id":"P32785","uniprot_name":"FMT_YEAST","enzyme":true,"transporter":false,"gene_name":"FMT1","num_residues":401,"molecular_weight":"44616.19922","theoretical_pi":"10.18","general_function":"Involved in methionyl-tRNA formyltransferase activity","specific_function":"Formylates methionyl-tRNA in mitochondria","reactions":[{"id":1730,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2493,"direction":"\u003e","locations":"Mitochondrion","altext":"10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) + H(2)O = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY490279","genbank_protein_id":"40457276","gene_card_id":"FMT1","chromosome_location":"chromosome 2","locus":"YBL013W","synonyms":["MtFMT"],"enzyme_classes":["2.1.2.9"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Function","description":" methionyl-tRNA formyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Formyl_trans_N","identifier":"PF00551"},{"name":"Formyl_trans_C","identifier":"PF02911"}],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"gene_sequence":"ATGGTTAAAATGAGAAGAATAACACCTACACGCCTCCTATTCACATGCAGATATATTTCAAACAATGCTTCTCCACCAGTGCAGCCCTTGAATGTGCTTTTCTTTGGTAGCGACACTTTCAGTAATTTCTCATTGCAAGCACTCAATGAGTTGCGTCAAAATAATGGAAGCTGTGGTATAGTGGACAATATTCAAGTAGTAACTAGGTCGCCGAAGTGGTGCGGTAGACAGAAGTCTATTTTGAAATACCCGCCGATCTTCGATATGGCAGAGAAGCTTCAATTGCCACGCCCAATTACATGCGACACCAAGCAGGAAATGTTGGCGCTAAGCAAACTGACACCCAGTCGCCAAGGAAATCCGGAGAACGACGGCTCCGGTGCTCCGTTCAACGCGATCATTGCGGTTTCTTTTGGGAAGCTCATTCCGGGTGACTTGATCCGCGCGGTGCCATTGGCGCTAAACGTCCATCCTTCGCTACTTCCCAGACATAAAGGCAGTGCACCTATCCAGCGAGCTCTGCTCGAGGGTGACACTTACACCGGTGTAACTATACAGACACTGCATCCGGATCGGTTTGACCATGGTGCAATTGTAGCGCAGACGGAGCCACTGGCGATCGCAACAATGCTGTCAAAAGGGAGAGTCAATGATTCGACGGCAGATTTTAATTCTGAGGGCCTGCCTCGGAGGACTGCCATACTGATGGACCAGTTGGGCGCCCTTGGCGCCCAACTTTTGGGCCAAACGCTTCGTGAGAGGTTATATCTACCACAGAACCGTGTGCAAGCGCCAACAGCTTACAAACCCAGTTACGCCCACCGTATAACAACAGAAGATAAACGCATTCATTGGGCGCGCGATTCTGCCGCCGAACTACTTAACAAACTCGAAACGCTCGGTCCTCTGCACGCGTTCAAAGAAGCGACAGCGGCAAGAAAGGACGCTCAAAATTCAGTATTAAAACGAATATTGTTTCATGAGTGTAAAGTGATGAGAGACGCACGTCTAGATAATGGCAGTAAACCGGGCATGTTCAAATATGATGATATTAAAGACTGTATTTTGGTCACCTGTCGCGGCAACTTACTACTATGTGTGAGCCGCCTCCAGTTCGAAGGTTTCGCCGTAGAACGTGCTGGCCAGTTCATGGCGCGCCTGCGGAAAAGATGCGGCGCCCTGAGTGAAAAGTTAGTTTTCCTGTAA","protein_sequence":"MVKMRRITPTRLLFTCRYISNNASPPVQPLNVLFFGSDTFSNFSLQALNELRQNNGSCGIVDNIQVVTRSPKWCGRQKSILKYPPIFDMAEKLQLPRPITCDTKQEMLALSKLTPSRQGNPENDGSGAPFNAIIAVSFGKLIPGDLIRAVPLALNVHPSLLPRHKGSAPIQRALLEGDTYTGVTIQTLHPDRFDHGAIVAQTEPLAIATMLSKGRVNDSTADFNSEGLPRRTAILMDQLGALGAQLLGQTLRERLYLPQNRVQAPTAYKPSYAHRITTEDKRIHWARDSAAELLNKLETLGPLHAFKEATAARKDAQNSVLKRILFHECKVMRDARLDNGSKPGMFKYDDIKDCILVTCRGNLLLCVSRLQFEGFAVERAGQFMARLRKRCGALSEKLVFL"},{"created_at":"2011-05-26T17:53:55.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"C-1-tetrahydrofolate synthase, cytoplasmic","uniprot_id":"P07245","uniprot_name":"C1TC_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE3","num_residues":946,"molecular_weight":"102204.0","theoretical_pi":"6.83","general_function":"Involved in formate-tetrahydrofolate ligase activity","specific_function":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH","reactions":[{"id":1548,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1727,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1733,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2488,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2489,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":2490,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY692966","genbank_protein_id":"51013383","gene_card_id":"ADE3","chromosome_location":"chromosome 7","locus":"YGR204W","synonyms":["C1-THF synthase","Methylenetetrahydrofolate dehydrogenase","Methenyltetrahydrofolate cyclohydrolase","Formyltetrahydrofolate synthetase"],"enzyme_classes":["1.5.1.5","3.5.4.9","6.3.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" formate-tetrahydrofolate ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FTHFS","identifier":"PF01268"},{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"gene_sequence":"ATGGCTGGTCAAGTGTTGGACGGCAAAGCATGCGCTCAGCAGTTTAGAAGCAATATTGCTAATGAAATCAAAAGCATTCAAGGTCACGTGCCTGGGTTTGCACCTAACCTTGCCATCATTCAAGTAGGCAACAGACCAGACTCAGCCACATATGTACGCATGAAGCGTAAGGCAGCTGAAGAGGCCGGCATTGTTGCTAATTTCATTCATTTAGATGAATCCGCTACTGAATTTGAAGTTCTGCGTTACGTGGACCAGCTGAATGAGGACCCACATACACACGGTATTATCGTGCAACTACCATTACCCGCTCATTTGGACGAGGATAGAATCACCTCGAGAGTGTTGGCAGAAAAGGACGTGGACGGGTTCGGGCCCACCAACATTGGCGAATTGAATAAGAAGAACGGACACCCATTCTTTTTGCCCTGCACGCCCAAGGGGATCATTGAGCTGCTTCACAAGGCCAACGTCACGATTGAAGGTTCCCGGTCCGTTGTGATCGGAAGATCTGACATTGTTGGCTCTCCTGTTGCAGAATTGTTAAAATCTCTAAACTCCACCGTCACCATCACTCATTCTAAAACCCGTGATATCGCATCATACTTACACGACGCGGACATCGTAGTCGTTGCCATCGGCCAACCAGAATTTGTGAAGGGTGAATGGTTCAAACCAAGAGACGGCACTTCCAGTGATAAGAAAACCGTGGTAATTGATGTTGGCACCAACTACGTTGCTGATCCTTCCAAAAAGTCCGGTTTCAAATGTGTTGGTGACGTTGAGTTCAATGAAGCAATCAAATACGTCCATCTAATCACTCCAGTGCCCGGTGGTGTGGGCCCCATGACGGTGGCTATGTTAATGCAAAATACCTTGATTGCTGCCAAACGCCAAATGGAAGAATCCTCGAAGCCTTTGCAGATTCCTCCCTTGCCATTGAAGTTGCTAACACCTGTTCCTTCCGATATAGACATCTCCAGAGCACAACAGCCAAAGCTTATCAACCAGCTTGCTCAAGAATTGGGTATTTACTCTCATGAGTTGGAGCTGTACGGACATTACAAGGCCAAAATTTCTCCTAAAGTCATCGAAAGGCTGCAGACGCGCCAAAATGGTAAGTACATCTTGGTGTCTGGTATCACACCAACACCACTGGGAGAGGGTAAATCCACTACAACAATGGGTCTTGTCCAGGCACTAACGGCTCACTTGGGCAAGCCAGCCATTGCGAACGTCAGACAACCCTCCCTAGGACCCACTTTAGGTGTCAAAGGTGGTGCTGCGGGTGGTGGTTATTCCCAAGTCATCCCAATGGACGAATTCAACTTACATTTGACTGGTGACATTCACGCCATTGGTGCGGCTAACAACCTACTTGCTGCCGCTATTGACACTAGAATGTTCCATGAGACCACTCAAAAGAACGACGCTACCTTCTACAACAGACTAGTGCCTAGAAAGAACGGAAAGAGAAAGTTTACTCCCTCCATGCAAAGAAGATTGAACAGACTGGGTATTCAAAAGACCAACCCCGATGATCTAACACCCGAAGAGATCAACAAATTCGCCAGATTGAACATTGACCCGGACACTATTACTATCAAGAGGGTGGTCGATATCAACGACAGAATGTTAAGACAAATCACCATTGGTCAAGCCCCTACCGAGAAGAACCACACAAGAGTTACTGGATTCGATATCACCGTTGCTTCTGAATTGATGGCTATTCTTGCTCTTTCAAAGGACTTGAGGGACATGAAGGAACGTATTGGAAGAGTCGTTGTTGCTGCTGACGTAAACAGGTCTCCAGTCACTGTTGAAGATGTGGGTTGTACCGGTGCCTTAACCGCTTTATTAAGAGACGCTATCAAGCCCAACTTGATGCAAACTTTAGAAGGTACTCCTGTCTTGGTCCATGCCGGCCCATTTGCCAACATCTCTATCGGTGCCTCTTCTGTTATTGCTGATCGCGTGGCTTTGAAATTGGTTGGTACCGAGCCAGAGGCAAAAACAGAAGCTGGTTATGTGGTTACTGAAGCAGGGTTCGATTTCACTATGGGTGGTGAAAGATTCTTCAACATCAAGTGCCGTTCCTCTGGATTGACACCTAATGCTGTGGTCTTGGTTGCTACTGTTAGGGCATTGAAGTCACACGGTGGTGCTCCAGATGTCAAACCTGGCCAACCTTTACCTTCCGCATACACTGAAGAGAATATCGAGTTTGTCGAAAAAGGTGCCGCTAACATGTGTAAACAAATTGCCAACATTAAGCAATTTGGCGTCCCCGTCGTTGTCGCAATTAACAAGTTTGAAACTGACACTGAAGGTGAAATAGCCGCCATTAGAAAAGCCGCTTTGGAAGCTGGTGCATTTGAAGCCGTAACCTCTAACCATTGGGCCGAAGGTGGTAAAGGTGCTATCGACTTGGCCAAGGCCGTCATCGAAGCTTCCAACCAACCAGTGGACTTCCATTTCCTATATGACGTTAACTCCTCCGTTGAAGACAAATTAACTACTATCGTTCAAAAGATGTACGGTGGTGCCGCAATCGATATCTTGCCTGAAGCACAACGCAAGATTGACATGTACAAGGAACAAGGTTTCGGTAACTTGCCAATTTGTATCGCCAAGACACAATACTCTTTATCCCACGATGCAACTTTGAAAGGTGTTCCAACCGGGTTCACTTTCCCCATCAGAGACGTCAGATTGTCTAATGGTGCTGGATACTTATACGCTCTTGCCGCCGAAATACAAACCATTCCTGGTTTGGCTACCTATGCTGGTTACATGGCCGTGGAAGTCGATGATGACGGTGAGATCGATGGCCTGTTCTAA","protein_sequence":"MAGQVLDGKACAQQFRSNIANEIKSIQGHVPGFAPNLAIIQVGNRPDSATYVRMKRKAAEEAGIVANFIHLDESATEFEVLRYVDQLNEDPHTHGIIVQLPLPAHLDEDRITSRVLAEKDVDGFGPTNIGELNKKNGHPFFLPCTPKGIIELLHKANVTIEGSRSVVIGRSDIVGSPVAELLKSLNSTVTITHSKTRDIASYLHDADIVVVAIGQPEFVKGEWFKPRDGTSSDKKTVVIDVGTNYVADPSKKSGFKCVGDVEFNEAIKYVHLITPVPGGVGPMTVAMLMQNTLIAAKRQMEESSKPLQIPPLPLKLLTPVPSDIDISRAQQPKLINQLAQELGIYSHELELYGHYKAKISPKVIERLQTRQNGKYILVSGITPTPLGEGKSTTTMGLVQALTAHLGKPAIANVRQPSLGPTLGVKGGAAGGGYSQVIPMDEFNLHLTGDIHAIGAANNLLAAAIDTRMFHETTQKNDATFYNRLVPRKNGKRKFTPSMQRRLNRLGIQKTNPDDLTPEEINKFARLNIDPDTITIKRVVDINDRMLRQITIGQAPTEKNHTRVTGFDITVASELMAILALSKDLRDMKERIGRVVVAADVNRSPVTVEDVGCTGALTALLRDAIKPNLMQTLEGTPVLVHAGPFANISIGASSVIADRVALKLVGTEPEAKTEAGYVVTEAGFDFTMGGERFFNIKCRSSGLTPNAVVLVATVRALKSHGGAPDVKPGQPLPSAYTEENIEFVEKGAANMCKQIANIKQFGVPVVVAINKFETDTEGEIAAIRKAALEAGAFEAVTSNHWAEGGKGAIDLAKAVIEASNQPVDFHFLYDVNSSVEDKLTTIVQKMYGGAAIDILPEAQRKIDMYKEQGFGNLPICIAKTQYSLSHDATLKGVPTGFTFPIRDVRLSNGAGYLYALAAEIQTIPGLATYAGYMAVEVDDDGEIDGLF"},{"created_at":"2011-05-27T07:06:11.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Spore wall maturation protein DIT1","uniprot_id":"P21623","uniprot_name":"DIT1_YEAST","enzyme":true,"transporter":false,"gene_name":"DIT1","num_residues":536,"molecular_weight":"61390.10156","theoretical_pi":"6.51","general_function":"Secondary metabolites biosynthesis, transport and catabolism","specific_function":"Involved in spore wall maturation. Catalyzes a two step reaction that leads to the LL-dityrosine containing precursor of the spore wall","reactions":[{"id":1708,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U32274","genbank_protein_id":"927334","gene_card_id":"DIT1","chromosome_location":"chromosome 4","locus":"YDR403W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[{"name":"DIT1_PvcA","identifier":"PF05141"}],"pathways":[],"gene_sequence":"ATGACATTTACTAGCAACTTGCCCTCAAGCTCCGAGCAGTCAATATCACCACCTGCCTCTTCATTTTCTTCATCGACTGATACGTTGAAAGATATTGATATTCCCCATAATGGGGCCGATTTGTCTACATATAGTAAATTTCTGGCCCTGTATTGCAGAAGCGACAAATGTGACGATTTTTACTCTTTAGAGGAAAAACAGAATTGTAAATTTGGAGACCAATGGCTCGACTTTATCAACACTATTCACAATCTGGACTTTTCTGAATCCGAAGTAAGTGGACGGGTTTCTGAAAGAATTTTGCCAGCTTCTTTAGCAAATAAATTTACCAATAATTTAGGAGTGGCAATAAAGATTTCTGAATATACACGCGATGACGAACGCCAGATTCGTGGGTGTGTTACAACAGTTGAGAATGAAAATTCTTTCAATAACTGGTTCGTATATCATATTTTAGACCAATCTCAATTATCTCTAAGTGAACATCCAATTGTAACCAAAGAAGTTAAGTATCACGAATTATTTGCAGATTTTTTTGAGAAAAATTTGAAAAACACAATAGTTAATGATCAATGGAATTTTGGTGGCCGTGATTATTTTATTGAACGTTCAAGATATTTTACCGATCGATATTTGAGAATTGAATGCATCTTGCCAGCGTTTCCATGTAAGTCATCTAATGAGCAAAAAGTGTACGGTTCCGTTCCTGACAAAGGCGAAGAACTCGCTTTGAAAAGATTAATAAAAGCCACACAAGACCTTGTCAAGATATATCCACCGGGTATGAAAATTTGGATAGTTAGTGATGGCCATGTTTTCTCCGATTGTATTGGGGTCGATGATGACGTCGTGAGTACTTACACGACCAAATTGCACGAACTGTATAAAAGAGTGGCTATACCTGGTGTTGACGCCATTGGCTTTTGTGGATTGAACGATTTATTTTTTAGCGGTGCAGCTAGTAAAGTTTTCGATCCAAAGTGGGTTAGTGATGTTGAAGTTGCACACTACACAGGAACTCAAATCTGTCCTAAGTCCGATTTGTCGAGACAGATTTTGATGAAAGGCTGTGATACAGATGCAGGTCGTTTGAGAAAGCAGATTGCAATAGAAGGACATCCAAGATTGCATCTGTATAGGGGCTTTTCACGTTTTATGATGGAAGATTTATCTCTACTGGAACATTTCCAAAGTTATTCCAGAAAAAAATTCAAGAAAATCATTTCAATGATCGCTTTTAACATGATTAAGAGAAATGACGCGTATTCGAACTTAGTGGAATTGATATTCCCTCATCATTTGAGAATTTCTATTCATGCGCACACTAACAGCGGGCCCAAATTTGGTATAAAAGTAATCTCCAACGAACAGTGTTCTATTGTTAGTTCGTTAGAAGACCTTGATGAACCCAAATTTGAAGATTTTTTACATATTCCCACACCTTGGCATAATTGTGTCGTGAAGGTTGAGGATGAAAAGGAGAAATACTTTTTGACAAAATCAAAAGTAGTCAAGGAGGCTCTCGAAAAGGGTATGTATGATGGTGTATGGAAAGATACTCGTTTCGATATTGGAGAAGGAGGACATTTCGTTATCAAGAAAATCTCTTAA","protein_sequence":"MTFTSNLPSSSEQSISPPASSFSSSTDTLKDIDIPHNGADLSTYSKFLALYCRSDKCDDFYSLEEKQNCKFGDQWLDFINTIHNLDFSESEVSGRVSERILPASLANKFTNNLGVAIKISEYTRDDERQIRGCVTTVENENSFNNWFVYHILDQSQLSLSEHPIVTKEVKYHELFADFFEKNLKNTIVNDQWNFGGRDYFIERSRYFTDRYLRIECILPAFPCKSSNEQKVYGSVPDKGEELALKRLIKATQDLVKIYPPGMKIWIVSDGHVFSDCIGVDDDVVSTYTTKLHELYKRVAIPGVDAIGFCGLNDLFFSGAASKVFDPKWVSDVEVAHYTGTQICPKSDLSRQILMKGCDTDAGRLRKQIAIEGHPRLHLYRGFSRFMMEDLSLLEHFQSYSRKKFKKIISMIAFNMIKRNDAYSNLVELIFPHHLRISIHAHTNSGPKFGIKVISNEQCSIVSSLEDLDEPKFEDFLHIPTPWHNCVVKVEDEKEKYFLTKSKVVKEALEKGMYDGVWKDTRFDIGEGGHFVIKKIS"}]}