{"ymdb_id":"YMDB00509","created_at":"2011-05-29T18:24:56.000Z","updated_at":"2016-09-08T18:35:33.000Z","name":"Guanosine","cas":"118-00-3","state":"Solid","melting_point":"239 oC","description":"Guanosine is a purine nucleoside. It is formed by a molecule of guanine attached to a ribose sugar molecule. Guanosine is the RNA nucleoside G. Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction and intracellular signal transduction.","experimental_water_solubility":"0.7 mg/mL at 18 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-1.90 [SANGSTER (1993)]","location":"extracellular;mitochondrion;cytoplasm","synthesis_reference":"Tang, Shengrong; Huang, Weihong; Hou, Zuorong.  Process of guanosine production by fermentation.    Gongye Weishengwu  (1998),  28(4),  11-16. ","chebi_id":"16750","hmdb_id":"HMDB00133","kegg_id":"C00387","pubchem_id":"6802","cs_id":"6544","foodb_id":null,"wikipedia_link":"Guanosine","biocyc_id":"GUANOSINE","iupac":"2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one","traditional_iupac":"guanosine","logp":"-2.706218196","pka":"12.456833616816144","alogps_solubility":"1.53e+01 g/l","alogps_logp":"-2.06","alogps_logs":"-1.27","acceptor_count":"8","donor_count":"5","rotatable_bond_count":"2","polar_surface_area":"155.22000000000003","refractivity":"64.62109999999998","polarizability":"26.0315249439995","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"0.4462064218132451","pka_strongest_acidic":"10.15572249859448","bioavailability":"1","number_of_rings":"3","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["\u0026beta;-D-ribofuranosyl-6H-purin-6-one","\u0026beta;-D-ribofuranosyl-9H-purin-6(1H)-one","2-Amino-1,9-dihydro-9-\u0026beta","2-Amino-1,9-dihydro-9-b-D-ribofuranosyl-6H-purin-6-one","2-Amino-1,9-dihydro-9beta-d-ribofuranosyl-6H-purin-6-one","2-amino-9-beta-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one","2-amino-Inosine","2(3H)-Imino-9-\u0026beta","2(3H)-Imino-9-beta-D-ribofuranosyl-9H-purin-6(1H)-one","6H-Purin-6-one, 2-amino-1,9-dihydro-9-beta-d-ribofuranosyl-","9-\u0026beta;-D-ribofuranosylguanine","9-b-D-ribofuranosyl-Guanine","9-beta-d-Arabinofuranosylguanine","9-beta-D-ribofuranosylguanine","9-beta-delta-ribofuranosyl-Guanine","b-D-Ribofuranoside guanine-9","beta-d-Ribofuranoside, guanine-9","beta-delta-Ribofuranoside guanine-9","GMP","guanine riboside","Guanine-9:beta-D-ribofuranoside","Guanine, 9beta-d-ribofuranosyl-","Guanosin","Guanosine","Guanosine, anhydrous","Guanozin","Guo","ribonucleoside","Vernine"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-24T20:49:32.000Z","updated_at":"2011-07-22T17:54:36.000Z","name":"Purine nucleoside phosphorylase","uniprot_id":"Q05788","uniprot_name":"PNPH_YEAST","enzyme":true,"transporter":false,"gene_name":"PNP1","num_residues":311,"molecular_weight":"33754.60156","theoretical_pi":"7.31","general_function":"Involved in purine-nucleoside phosphorylase activity","specific_function":"Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules","reactions":[{"id":1447,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1915,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1916,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1917,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1918,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1919,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1920,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1921,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2012,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2349,"direction":"\u003e","locations":null,"altext":"Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557950","genbank_protein_id":"45269792","gene_card_id":"PNP1","chromosome_location":"chromosome 12","locus":"YLR209C","synonyms":["PNP","Inosine phosphorylase"],"enzyme_classes":["2.4.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" purine-nucleoside phosphorylase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"}],"pfams":[{"name":"PNP_UDP_1","identifier":"PF01048"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"}],"gene_sequence":"ATGAGTGATATCTTGAACGTAAGTCAACAACGTGAAGCAATTACCAAGGCCGCTGCGTATATTTCTGCTATTTTAGAACCACATTTCAAAAATACAACAAATTTCGAGCCTCCGAGAACTTTGATTATATGTGGTTCAGGGCTTGGTGGAATATCTACCAAGCTGTCTAGAGACAATCCACCCCCGGTAACAGTCCCATACCAAGACATCCCAGGATTCAAGAAAAGTACGGTTCCAGGTCATTCCGGTACACTAATGTTCGGATCTATGAATGGTTCACCAGTAGTATTAATGAATGGTCGTCTTCATGGATATGAAGGCAACACATTGTTTGAGACTACTTTTCCTATTAGAGTGCTTAACCACATGGGTCATGTTCGTAATTTAATTGTCACTAATGCCGCTGGTGGTATAAACGCGAAATATCAAGCCTGCGATTTGATGTGCATTTATGATCATTTAAATATCCCTGGCCTTGCTGGCCAGCACCCATTGAGAGGTCCTAACTTGGATGAAGATGGACCTCGTTTTTTAGCCTTGAGTGATGCATATGATCTGGAGTTGAGGAAGCTTTTATTTAAGAAATGGAAAGAGCTCAAGATTCAAAGGCCACTGCATGAAGGTACTTATACTTTTGTATCTGGACCCACTTTCGAAACAAGAGCAGAATCCAAAATGATAAGGATGTTGGGAGGAGATGCTGTCGGAATGAGTACTGTTCCCGAAGTCATTGTTGCAAGACATTGCGGATGGAGGGTTTTGGCCTTAAGTTTGATTACCAATACTTGCGTGGTGGATAGCCCTGCCAGTGCGTTGGACGAATCACCTGTACCCTTAGAAAAAGGCAAAGCGACTCACGCTGAAGTACTGGAGAATGGTAAAATCGCCTCTAATGACGTGCAAAACTTAATTGCTGCCGTAATGGGGGAATTATAA","protein_sequence":"MSDILNVSQQREAITKAAAYISAILEPHFKNTTNFEPPRTLIICGSGLGGISTKLSRDNPPPVTVPYQDIPGFKKSTVPGHSGTLMFGSMNGSPVVLMNGRLHGYEGNTLFETTFPIRVLNHMGHVRNLIVTNAAGGINAKYQACDLMCIYDHLNIPGLAGQHPLRGPNLDEDGPRFLALSDAYDLELRKLLFKKWKELKIQRPLHEGTYTFVSGPTFETRAESKMIRMLGGDAVGMSTVPEVIVARHCGWRVLALSLITNTCVVDSPASALDESPVPLEKGKATHAEVLENGKIASNDVQNLIAAVMGEL"},{"created_at":"2011-05-27T17:15:59.000Z","updated_at":"2011-07-22T17:53:59.000Z","name":"Uridine nucleosidase","uniprot_id":"Q04179","uniprot_name":"URH1_YEAST","enzyme":true,"transporter":false,"gene_name":"URH1","num_residues":340,"molecular_weight":"37960.0","theoretical_pi":"5.07","general_function":"Involved in hydrolase activity, hydrolyzing N-glycosyl compounds","specific_function":"Also acts on cytidine","reactions":[{"id":1269,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1609,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2835,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Uridine + H(2)O = D-ribose + uracil.","export":false,"pw_reaction_id":null,"source":null},{"id":4195,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006494","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"URH1","chromosome_location":"chromosome 4","locus":"YDR400W","synonyms":["Uridine ribohydrolase"],"enzyme_classes":["3.2.2.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on glycosyl bonds"},{"category":"Function","description":" hydrolase activity, hydrolyzing N-glycosyl compounds"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IU_nuc_hydro","identifier":"PF01156"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTGTTAGTAAAATACCCATATGGCTAGATTGTGATCCTGGTCATGATGATGCCATAGCCATTTTATTAGGCTGTTTCCATCCAGCTTTCAATCTTCTAGGAATCAGCACGTGTTTTGGTAACGCACCGCCAGAGAATACTGACTACAACGCCCGTTCTCTTTTGACTGCGATGGGCAAAGCACAAGCGATTCCAGTTTATAAAGGCGCACAGAGACCTTGGAAAAGGGAACCTCATTATGCTCCTGACATTCATGGTATATCAGGTTTAGACGGCACTTCTTTGCTACCTAAGCCAACATTTGAGGCAAGAACTGATAAAACGTATATTGAGGCCATTGAAGAGGCGATTCTAGCTAACAATGGAGAGATATCCTTTGTGTCTACTGGTGCACTTACCACATTAGCAACAGTTTTTAGGTGTAAACCATACCTAAAAAAATCTGTCAAATATATTAGCATTATGGGGGGTGGACTCCATGGTCTAGGAAACTGTAACCCAAATCTTTCTGCTGAATTCAACGTTTGGATTGATCCTGACGCAGCGAATTACATATTCCGTGATCCCGATGTAAAGGACAAATGTATAGTAGTTCCTCTAAATTTAACTCACAAGGCCATAGCTACTTACAAGGTTAACGAAATGATATACAACGAAAAGAATAACAGCAAGTTACGAGAATTGTTTTTGGAGCTTTTTCAATTTTTTGCTCATACCTACAAGGATATGCAAGGATTTGAATCGGGCCCACCTATACATGATCCGGTAGCTTTGATGCCGCTTTTGGAATTTTATGGGTGGGATCCATCGTCTGCGGTTGGATTTCGCTACAAGAGAATGGACATATCCTGCATTGATGATGTTTTCAACGAAAACTCAGGGAAAATTATCATTGAAAAAGAATATCCAAATGACAGTGATGTTGGTACAATAATTGGTCTCGATTTGAATATCCAGTACTTTTGGGATCAGATTTTTGAAGCATTAAATAGAGCAGACAAAATGTCAACGATTGGATAA","protein_sequence":"MTVSKIPIWLDCDPGHDDAIAILLGCFHPAFNLLGISTCFGNAPPENTDYNARSLLTAMGKAQAIPVYKGAQRPWKREPHYAPDIHGISGLDGTSLLPKPTFEARTDKTYIEAIEEAILANNGEISFVSTGALTTLATVFRCKPYLKKSVKYISIMGGGLHGLGNCNPNLSAEFNVWIDPDAANYIFRDPDVKDKCIVVPLNLTHKAIATYKVNEMIYNEKNNSKLRELFLELFQFFAHTYKDMQGFESGPPIHDPVALMPLLEFYGWDPSSAVGFRYKRMDISCIDDVFNENSGKIIIEKEYPNDSDVGTIIGLDLNIQYFWDQIFEALNRADKMSTIG"}]}