{"ymdb_id":"YMDB00384","created_at":"2011-05-29T18:11:35.000Z","updated_at":"2016-09-08T18:35:25.000Z","name":"2-Oxo-3-hydroxy-4-phosphobutanoic acid","cas":null,"state":"Solid","melting_point":"","description":"2-Oxo-3-hydroxy-4-phosphobutanoic acid is involved in the interconversion of O-phospho-4-hydroxy-L-threonine. This reaction is catalyzed by phosphoserine aminotransferase 1.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":null,"chebi_id":"27951","hmdb_id":"HMDB06801","kegg_id":"C06054","pubchem_id":"112","cs_id":"24785138","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(3R)-3-hydroxy-2-oxo-4-(phosphonooxy)butanoic acid","traditional_iupac":"(3R)-3-hydroxy-2-oxo-4-(phosphonooxy)butanoic acid","logp":"-1.3530858483333335","pka":"2.775362844628003","alogps_solubility":"1.62e+01 g/l","alogps_logp":"-2.01","alogps_logs":"-1.12","acceptor_count":"7","donor_count":"4","rotatable_bond_count":"5","polar_surface_area":"141.36","refractivity":"36.602399999999996","polarizability":"15.260088660826515","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":"-3.9601866599060154","pka_strongest_acidic":"1.3366600113332643","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(3R)-3-Hydroxy-2-oxo-4-phosphonooxybutanoate","(3R)-3-Hydroxy-2-oxo-4-phosphonooxybutanoic acid","2-Oxo-3-hydroxy-4-phosphobutanoate","2-Oxo-3-hydroxy-4-phosphobutanoic acid","alpha-Keto-3-hydroxy-4-phosphobutyrate"],"pathways":[{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"},{"name":"Vitamin B6","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-26T17:20:37.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Phosphoserine aminotransferase","uniprot_id":"P33330","uniprot_name":"SERC_YEAST","enzyme":true,"transporter":false,"gene_name":"SER1","num_residues":395,"molecular_weight":"43415.19922","theoretical_pi":"6.52","general_function":"Involved in metabolic process","specific_function":"Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to 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