{"ymdb_id":"YMDB00377","created_at":"2011-05-29T18:11:00.000Z","updated_at":"2016-09-08T18:35:25.000Z","name":"(S)-Ureidoglycolic acid","cas":"7424-03-5","state":"Solid","melting_point":"","description":"(S)-Ureidoglycolic acid is an hydrolysis product of allantoate in the allantoin degradation to glyoxylate pathway. Allantoin is a common product of purine degradation. Allantoin is rich in nitrogen and many organisms are able to degrade it and recycle it. Yeast can use allantoin as sole nitrogen source by degrading it to urea, CO2 and glyoxylate. Urea is further degraded to ammonia. [Biocyc PWY-5694]","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":null,"synthesis_reference":null,"chebi_id":"15412","hmdb_id":"HMDB01005","kegg_id":"C00603","pubchem_id":"439269","cs_id":"388403","foodb_id":null,"wikipedia_link":null,"biocyc_id":"CPD-1091","iupac":"(2S)-2-(carbamoylamino)-2-hydroxyacetic acid","traditional_iupac":"ureidoglycolate","logp":"-1.9509141746666665","pka":"12.093003710609045","alogps_solubility":"6.79e+01 g/l","alogps_logp":"-2.06","alogps_logs":"-0.30","acceptor_count":"4","donor_count":"4","rotatable_bond_count":"2","polar_surface_area":"112.65","refractivity":"25.3223","polarizability":"10.801086227324335","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-3.8235949501629993","pka_strongest_acidic":"2.9435169172851916","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(-)-Ureidoglycolate","(-)-Ureidoglycolic acid","(S)-[(aminocarbonyl)amino]hydroxy-acetic acid","(S)-Ureidoglycolate","(S)-Ureidoglycolic acid","S-(-)-Ureidoglycolic acid","ureidoglycolate"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."}],"proteins":[{"created_at":"2011-05-24T19:44:14.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Allantoicase","uniprot_id":"P25335","uniprot_name":"ALLC_YEAST","enzyme":true,"transporter":false,"gene_name":"DAL2","num_residues":343,"molecular_weight":"38713.5","theoretical_pi":"6.33","general_function":"Involved in allantoicase activity","specific_function":"Utilization of purines as secondary nitrogen sources, when primary sources are limiting","reactions":[{"id":1310,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2268,"direction":"\u003e","locations":"Cytoplasmic","altext":"Allantoate + H(2)O = (S)-ureidoglycolate + urea.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1SG3","cellular_location":"Cytoplasmic","genbank_gene_id":"M64720","genbank_protein_id":"171368","gene_card_id":"DAL2","chromosome_location":"chromosome 9","locus":"YIR029W","synonyms":["Allantoate amidinohydrolase"],"enzyme_classes":["3.5.3.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"},{"category":"Function","description":" allantoicase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Allantoicase","identifier":"PF03561"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGAAGTTTTTTAGTTTGGCAGATGAGGCAGAATTTAAGTCAATAATCATTTCAAAAAACAAAGCAGTAGATGTTATAGGATCTAAGTTAGGTGGTCAAGTGGTTTCTTTTTCAGATGAATGGTTTGCTTCTGCTGAAAATTTAATTCAGCCAACTGCTCCTATAAGGGATCCTACCAGATTTGTTCATTCAGGCGCATGGTACGACGGCTGGGAAACACGAAGACATAATGAGATGGAATACGATTGGGTTATCATCAAGATGGGAGTCGCTGCTGCCCATATTATTGGTGGTGAAATTGACACTGCGTTTTTCAATGGTAATCATGCACCATTTGTATCAATAGAGGCGCTCTATGACGAGGGCGAAGAAGGTAATATAGTGGAAGATGACTCGCGTTGGGTTGAGATTGTTGAGAAATTTGAGTGTGGTCCTTCGCAAAGGCATCTTTTCGTTAGAGGCAACGGCCTTACTAAAGAAAGGTTTACTCACATCAAGCTGAAGATGTACCCCGATGGAGGAATCGCCAGATTTAGATTATACGGAAGAGTTGTTCCTCCAGAACTCAAAACGAAGGATCATATAATTGACTTGGCTTATGTTTGCAATGGTGCTGTCGCTTTAAAGTATTCTGACCAACACTTCGGTTCAGTTGATAATTTGCTACTGCCAGGTCGAGGTCATGATATGTCGGACGGCTGGGAAACCAAAAGATCGAGACAACCAGGTCATACTGATTGGGCGGTAATTCAACTGGGCAGGGAGTCTTCTTTCATTGAGAAGATTATTGTTGATACGGCACACTTCAGGGGGAACTTCCCTCAGTTCATTACCGTGGAAGGTTGCTTGAAGGAGTCAGAATCAAGTGAGAACACTGGTGAAGGAACATGGGTAGAGCTAGTTGGTAAGTCAAAGACGGGGCCTGACAAAGAACATGTGTATGAAATACGTAAGAGTATAAGAGTCTCCCATGTCAAATTAACGATTATTCCAGATGGAGGAGTGAAAAGAATAAGAGTTTGGGGGTACTGA","protein_sequence":"MKFFSLADEAEFKSIIISKNKAVDVIGSKLGGQVVSFSDEWFASAENLIQPTAPIRDPTRFVHSGAWYDGWETRRHNEMEYDWVIIKMGVAAAHIIGGEIDTAFFNGNHAPFVSIEALYDEGEEGNIVEDDSRWVEIVEKFECGPSQRHLFVRGNGLTKERFTHIKLKMYPDGGIARFRLYGRVVPPELKTKDHIIDLAYVCNGAVALKYSDQHFGSVDNLLLPGRGHDMSDGWETKRSRQPGHTDWAVIQLGRESSFIEKIIVDTAHFRGNFPQFITVEGCLKESESSENTGEGTWVELVGKSKTGPDKEHVYEIRKSIRVSHVKLTIIPDGGVKRIRVWGY"},{"created_at":"2011-05-24T20:50:12.000Z","updated_at":"2011-05-27T14:56:01.000Z","name":"Ureidoglycolate hydrolase","uniprot_id":"P32459","uniprot_name":"ALLA_YEAST","enzyme":true,"transporter":false,"gene_name":"DAL3","num_residues":195,"molecular_weight":"21726.59961","theoretical_pi":"5.06","general_function":"Involved in ureidoglycolate hydrolase activity","specific_function":"Utilization of purines as secondary nitrogen sources, when primary sources are limiting","reactions":[{"id":2036,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2350,"direction":"\u003e","locations":"Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)","altext":"(S)-ureidoglycolate + H(2)O = glyoxylate + 2 NH(3) + CO(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)","genbank_gene_id":"M64778","genbank_protein_id":"171370","gene_card_id":"DAL3","chromosome_location":"chromosome 9","locus":"YIR032C","synonyms":[],"enzyme_classes":["3.5.3.19"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"},{"category":"Function","description":" ureidoglycolate hydrolase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" amine metabolic process"},{"category":"Process","description":" allantoin metabolic process"},{"category":"Process","description":" allantoin catabolic process"}],"pfams":[{"name":"Ureidogly_hydro","identifier":"PF04115"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGGTGACCGTGGTGGCGGAGACATTGACGAAAGAGTCCTTCGAGGAGTATGGGACGATAATTTCGCCAGATGAAGAGATTTCAAGGATGCAAAACCTTGAAAAAGGTGCAAACCAGGGAACAGCGATCAAATTGCTTCAAGTAAGCCAGGTAGAGAATAAATCTACCAGTAAAGTTCCCAATTGGAACCTATTCCGTTGCTTTCCACAGCCGCACCTGAATAGAGTATTCACTCAAGGCTCCAATCAGGCGATTTCTCATTCTATCAAAGTCCTCGAAAAGCATCCGTGTAGTACGCAGACGTTTGTGCCTATGGGGAGAACGTCAGCGGAAGTAGCATACTTGGTAGTAGTCGCTAAAGAAATTGGAAATAAGCCAGACTTGTCTACGTTGAGGGCTTTTACATGTTTGGGTAATCAGGCCGTTACCTATGGCTTAGGTACCTGGCATGCGCCCATGATAGTACTTGGCAAGGAAGAACATTTGGATTTTTCAGTCTTAATCTACGAAAGTCTGGACCCTGACAGGCCCGAGAAGGACTGTGTGGAAGAACACTACAGCGATGGCGACGTTTGTATTATCATCTAA","protein_sequence":"MVTVVAETLTKESFEEYGTIISPDEEISRMQNLEKGANQGTAIKLLQVSQVENKSTSKVPNWNLFRCFPQPHLNRVFTQGSNQAISHSIKVLEKHPCSTQTFVPMGRTSAEVAYLVVVAKEIGNKPDLSTLRAFTCLGNQAVTYGLGTWHAPMIVLGKEEHLDFSVLIYESLDPDRPEKDCVEEHYSDGDVCIII"}]}