{"ymdb_id":"YMDB00374","created_at":"2011-05-29T18:10:45.000Z","updated_at":"2016-09-08T18:35:24.000Z","name":"Glycineamideribotide","cas":"10074-18-7","state":"Solid","melting_point":null,"description":"Glycinamidoribotide is an intermediate in de novo purine biosynthesis, a reaction catalyzed by the enzyme glycinamide ribonucleotide transformylase [EC 2.1.2.2].","experimental_water_solubility":null,"experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":null,"chebi_id":"18349","hmdb_id":"HMDB02022","kegg_id":"C03838","pubchem_id":"440137","cs_id":"141370","foodb_id":null,"wikipedia_link":"Glycineamideribotide","biocyc_id":"5-PHOSPHO-RIBOSYL-GLYCINEAMIDE","iupac":"{[(2R,3S,4R,5R)-5-(2-aminoacetamido)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid","traditional_iupac":"glycineamide ribonucleotide","logp":"-4.650616976017661","pka":"6.245768050847792","alogps_solubility":"1.46e+01 g/l","alogps_logp":"-2.40","alogps_logs":"-1.29","acceptor_count":"8","donor_count":"6","rotatable_bond_count":"5","polar_surface_area":"171.57000000000002","refractivity":"55.2948","polarizability":"23.677380162378174","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"8.141960108603826","pka_strongest_acidic":"1.2255744528280514","bioavailability":"1","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["5'-Phosphoribosyl-glycineamide","5'-Phosphoribosylglycinamide","5'-Phosphoribosylglycineamide","GAR","Glycinamide ribonucleotide","Glycineamide ribonucleotide","N-glycyl-5-O-phosphono-D-ribofuranosylamine","N(1)-(5-phospho-D-ribosyl)glycinamide","N1-(5-phospho-D-ribosyl)glycinamide"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"One Carbon Pool by Folate I","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."}],"proteins":[{"created_at":"2011-05-24T19:22:02.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"Phosphoribosylglycinamide formyltransferase","uniprot_id":"P04161","uniprot_name":"PUR3_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE8","num_residues":214,"molecular_weight":"23540.0","theoretical_pi":"6.39","general_function":"Involved in hydroxymethyl-, formyl- and related transferase activity","specific_function":"10-formyltetrahydrofolate + N(1)-(5-phospho-D- ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide","reactions":[{"id":1890,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2249,"direction":"\u003e","locations":null,"altext":"10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.","export":false,"pw_reaction_id":null,"source":null},{"id":4151,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006449","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M36585","genbank_protein_id":"171015","gene_card_id":"ADE8","chromosome_location":"chromosome 4","locus":"YDR408C","synonyms":["5'-phosphoribosylglycinamide transformylase","GAR transformylase","GART"],"enzyme_classes":["2.1.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphoribosylglycinamide formyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic 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5-amino-1-(5-phospho-D-ribosyl)imidazole.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X04337","genbank_protein_id":"3335","gene_card_id":"ADE5","chromosome_location":null,"locus":"YGL234W","synonyms":["Phosphoribosylamine--glycine ligase","Glycinamide ribonucleotide synthetase","GARS","Phosphoribosylglycinamide synthetase","Phosphoribosylformylglycinamidine cyclo-ligase","AIR synthase","AIRS","Phosphoribosyl-aminoimidazole synthetase"],"enzyme_classes":["6.3.4.13","6.3.3.1"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" phosphoribosylformylglycinamidine cyclo-ligase activity"},{"category":"Function","description":" phosphoribosylamine-glycine ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" cyclo-ligase activity"},{"category":"Process","description":" IMP biosynthetic process"},{"category":"Process","description":" 'de novo' IMP biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" nitrogen compound metabolic 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CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":14240,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006683","source":"Smpdb"},{"id":14241,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006686","source":"Smpdb"},{"id":14242,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006799","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M59824","genbank_protein_id":"171003","gene_card_id":"ADE2","chromosome_location":"chromosome 15","locus":"YOR128C","synonyms":["AIR carboxylase","AIRC"],"enzyme_classes":["4.1.1.21"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphoribosylaminoimidazole carboxylase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" IMP biosynthetic process"},{"category":"Process","description":" 'de novo' IMP biosynthetic process"}],"pfams":[{"name":"AIRC","identifier":"PF00731"},{"name":"ATP-grasp","identifier":"PF02222"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"One Carbon Pool by Folate 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