{"ymdb_id":"YMDB00368","created_at":"2011-05-29T18:10:16.000Z","updated_at":"2016-09-08T18:35:24.000Z","name":"3-Isopropylmalate","cas":"921-28-8","state":"Solid","melting_point":"","description":"3-Isopropylmalate is an intermediate in valine, leucine and isoleucine biosynthesis. It is a substrate for 3-isopropylmalate dehydrogenase and can be generated from the reduction of 2-isopropyl-3-oxosuccinate.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":null,"chebi_id":"43468","hmdb_id":"HMDB12156","kegg_id":"C04411","pubchem_id":"5462261","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":"2-D-THREO-HYDROXY-3-CARBOXY-ISOCAPROATE","iupac":"(2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioic acid","traditional_iupac":"(2R,3S)-3-isopropylmalic acid","logp":"0.1609326116666665","pka":"5.519667331107795","alogps_solubility":"8.33e+01 g/l","alogps_logp":"0.28","alogps_logs":"-0.33","acceptor_count":"5","donor_count":"3","rotatable_bond_count":"4","polar_surface_area":"94.83000000000001","refractivity":"38.5993","polarizability":"16.470268701415307","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-4.015599488752675","pka_strongest_acidic":"3.6770578154838125","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioate","(2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioic acid","(2R,3S)-2-hydroxy-3-isopropylsuccinate","(2R,3S)-2-hydroxy-3-isopropylsuccinic acid","(2R,3S)-3-carboxy-2-hydroxy-4-methylpentanoate","(2R,3S)-3-carboxy-2-hydroxy-4-methylpentanoic acid","(2R,3S)-3-Isopropylmalate","(2R,3S)-3-isopropylmalic acid","2-D-threo-Hydroxy-3-carboxy-isocaproate","2-D-threo-Hydroxy-3-carboxy-isocaproic acid","2-D-threo-hydroxy-3-carboxyisocaproate","2-D-threo-hydroxy-3-carboxyisocaproic acid","3-3-isopropylmalic acid","3-Carboxy-2-hydroxy-4-methylpentanoate","3-Carboxy-2-hydroxy-4-methylpentanoic acid","3-Isopropylmalate","IPM"],"pathways":[{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Leucine Biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":15147181,"citation":"Katz, J. E., Dumlao, D. S., Wasserman, J. I., Lansdown, M. G., Jung, M. E., Faull, K. F., Clarke, S. (2004). \"3-Isopropylmalate is the major endogenous substrate of the Saccharomyces cerevisiae trans-aconitate methyltransferase.\" Biochemistry 43:5976-5986."}],"proteins":[{"created_at":"2011-05-26T19:31:00.000Z","updated_at":"2011-07-22T17:53:47.000Z","name":"3-isopropylmalate dehydratase","uniprot_id":"P07264","uniprot_name":"LEUC_YEAST","enzyme":true,"transporter":false,"gene_name":"LEU1","num_residues":779,"molecular_weight":"85793.70313","theoretical_pi":"5.69","general_function":"Involved in 3-isopropylmalate dehydratase activity","specific_function":"Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate","reactions":[{"id":1147,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1182,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2574,"direction":"\u003e","locations":null,"altext":"(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmaleate + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":2575,"direction":"\u003e","locations":null,"altext":"(2S)-2-isopropylmaleate + H(2)O = (2S)-2-isopropylmalate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z72531","genbank_protein_id":"1322463","gene_card_id":"LEU1","chromosome_location":"chromosome 7","locus":"YGL009C","synonyms":["Alpha-IPM isomerase","IPMI","Isopropylmalate isomerase"],"enzyme_classes":["4.2.1.33"],"go_classes":[{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Component","description":" 3-isopropylmalate dehydratase complex"},{"category":"Function","description":" 4 iron, 4 sulfur cluster binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" 3-isopropylmalate dehydratase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" hydro-lyase activity"},{"category":"Process","description":" branched chain family amino acid metabolic process"},{"category":"Process","description":" leucine metabolic process"},{"category":"Process","description":" leucine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"}],"pfams":[{"name":"Aconitase","identifier":"PF00330"},{"name":"Aconitase_C","identifier":"PF00694"}],"pathways":[{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGGTTTACACTCCATCCAAGGGTCCAAGAACTCTTTACGATAAGGTTTTTGATGCACATGTTGTCCATCAAGATGAAAATGGTTCCTTTTTGTTGTATATCGACAGACACTTGGTTCATGAAGTCACCTCTCCACAAGCTTTCGAAGGCCTAGAAAATGCCGGCAGAAAGGTCAGAAGAGTTGATTGTACTCTAGCTACTGTAGATCATAATATTCCAACTGAATCAAGAAAGAATTTCAAATCACTAGACACATTTATCAAGCAAACTGATTCGCGTTTACAAGTCAAAACTTTAGAGAATAATGTTAAACAGTTCGGCGTTCCATATTTCGGTATGAGTGATGCCAGACAAGGTATCGTCCACACCATCGGTCCCGAAGAAGGTTTCACTTTACCAGGTACCACTGTTGTTTGTGGTGACTCTCATACCTCTACTCACGGTGCCTTTGGTTCGCTGGCCTTTGGTATTGGTACTTCTGAAGTTGAACACGTCTTGGCCACTCAAACAATTATCCAAGCTAAATCGAAAAACATGAGAATTACTGTTAATGGTAAGCTATCACCTGGTATCACATCTAAAGATTTGATTTTGTATATTATTGGTCTGATAGGTACTGCAGGTGGTACTGGTTGCGTTATTGAATTCGCAGGTGAAGCCATTGAAGCTCTTTCTATGGAAGCACGTATGTCCATGTGTAACATGGCCATCGAAGCTGGTGCAAGAGCAGGTATGATTAAACCAGACGAAACTACTTTCCAATACACCAAAGGCAGACCTTTGGCTCCAAAAGGTGCCGAATGGGAAAAGGCTGTTGCCTACTGGAAAACTTTGAAAACAGACGAAGGTGCCAAATTTGACCACGAAATCAACATTGAAGCTGTCGACGTGATTCCAACTATTACATGGGGTACTTCTCCTCAAGATGCCTTACCAATTACTGGTTCCGTACCAGATCCAAAAAATGTTACAGACCCAATAAAGAAATCTGGTATGGAAAGAGCCTTAGCCTATATGGGTTTGGAACCTAACACACCGCTAAAGAGCATCAAAGTAGATAAAGTCTTTATTGGATCTTGTACCAATGGCCGTATTGAAGATTTAAGAAGTGCTGCAGCTGTAGTTAGGGGTCAAAAATTGGCTAGTAACATCAAATTAGCTATGGTTGTTCCGGGATCTGGTTTGGTCAAAAAACAAGCCGAAGCAGAAGGTTTGGACAAGATTTTCCAAGAAGCTGGTTTTGAATGGAGAGAAGCTGGTTGTTCAATATGTTTAGGTATGAACCCTGATATTTTGGATGCCTATGAACGTTGTGCTTCTACTTCCAACAGAAATTTCGAAGGTCGTCAAGGTGCCTTGTCTCGTACACATCTAATGTCCCCAGCCATGGCGGCTGCTGCAGGTATCGCAGGTCACTTCGTAGATATTAGAGAATTCGAATATAAGGATCAAGACCAAAGTAGTCCAAAGGTTGAGGTCACTTCCGAAGATGAAAAAGAGCTTGAAAGTGCTGCTTACGATCACGCTGAACCTGTCCAACCCGAAGACGCTCCCCAAGATATTGCCAATGATGAATTAAAAGATATTCCAGTGAAGTCAGATGATACACCTGCTAAACCTAGCTCTTCCGGCATGAAGCCATTTTTGACTTTGGAAGGTATTAGCGCACCATTAGATAAGGCCAATGTTGATACAGACGCTATTATCCCAAAGCAATTTTTAAAGACAATTAAGAGAACGGGTTTGAAAAAAGGGTTGTTTTATGAATGGCGTTTCCGTAAAGACGATCAAGGTAAGGATCAAGAAACCGATTTTGTATTAAATGTTGAACCTTGGAGGGAAGCTGAAATATTGGTTGTTACTGGTGACAATTTCGGATGTGGTTCTTCCAGAGAACACGCACCATGGGCTCTAAAAGACTTTGGTATAAAATCCATCATTGCACCTTCTTACGGTGATATTTTCTACAACAACTCTTTCAAGAACGGCTTATTACCTATTAGATTGGATCAACAAATAATCATTGACAAATTGATCCCTATTGCTAATAAGGGTGGTAAGCTCTGCGTCGATTTACCAAATCAAAAAATTTTGGATTCCGATGGCAATGTGCTCGTTGATCATTTTGAAATAGAACCTTTCAGAAAGCACTGCCTAGTTAACGGTCTTGATGATATTGGTATTACATTGCAAAAGGAAGAATACATTTCCAGATACGAAGCTTTGAGAAGAGAGAAATACTCATTCTTGGAAGGTGGATCAAAATTATTAAAATTTGACAACGTTCCAAAAAGAAAAGCTGTTACAACTACTTTCGATAAAGTCCACCAGGATTGGTAG","protein_sequence":"MVYTPSKGPRTLYDKVFDAHVVHQDENGSFLLYIDRHLVHEVTSPQAFEGLENAGRKVRRVDCTLATVDHNIPTESRKNFKSLDTFIKQTDSRLQVKTLENNVKQFGVPYFGMSDARQGIVHTIGPEEGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTIIQAKSKNMRITVNGKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMSMCNMAIEAGARAGMIKPDETTFQYTKGRPLAPKGAEWEKAVAYWKTLKTDEGAKFDHEINIEAVDVIPTITWGTSPQDALPITGSVPDPKNVTDPIKKSGMERALAYMGLEPNTPLKSIKVDKVFIGSCTNGRIEDLRSAAAVVRGQKLASNIKLAMVVPGSGLVKKQAEAEGLDKIFQEAGFEWREAGCSICLGMNPDILDAYERCASTSNRNFEGRQGALSRTHLMSPAMAAAAGIAGHFVDIREFEYKDQDQSSPKVEVTSEDEKELESAAYDHAEPVQPEDAPQDIANDELKDIPVKSDDTPAKPSSSGMKPFLTLEGISAPLDKANVDTDAIIPKQFLKTIKRTGLKKGLFYEWRFRKDDQGKDQETDFVLNVEPWREAEILVVTGDNFGCGSSREHAPWALKDFGIKSIIAPSYGDIFYNNSFKNGLLPIRLDQQIIIDKLIPIANKGGKLCVDLPNQKILDSDGNVLVDHFEIEPFRKHCLVNGLDDIGITLQKEEYISRYEALRREKYSFLEGGSKLLKFDNVPKRKAVTTTFDKVHQDW"},{"created_at":"2011-05-27T01:57:53.000Z","updated_at":"2011-07-22T17:53:47.000Z","name":"3-isopropylmalate dehydrogenase","uniprot_id":"P04173","uniprot_name":"LEU3_YEAST","enzyme":true,"transporter":false,"gene_name":"LEU2","num_residues":364,"molecular_weight":"38952.5","theoretical_pi":"5.48","general_function":"Involved in magnesium ion binding","specific_function":"Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate","reactions":[{"id":1183,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2649,"direction":"\u003e","locations":"Cytoplasm","altext":"(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO(2) + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X03840","genbank_protein_id":"4698","gene_card_id":"LEU2","chromosome_location":"chromosome 3","locus":"YCL018W","synonyms":["3-IPM-DH","IMDH","Beta-IPM dehydrogenase"],"enzyme_classes":["1.1.1.85"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" 3-isopropylmalate dehydrogenase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" branched chain family amino acid metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" leucine metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" leucine biosynthetic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Iso_dh","identifier":"PF00180"}],"pathways":[{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"}],"gene_sequence":"ATGTCTGCCCCTAAGAAGATCGTCGTTTTGCCAGGTGACCACGTTGGTCAAGAAATCACAGCCGAAGCCATTAAGGTTCTTAAAGCTATTTCTGATGTTCGTTCCAATGTCAAGTTCGATTTCGAAAATCATTTAATTGGTGGTGCTGCTATCGATGCTACAGGTGTCCCACTTCCAGATGAGGCGCTGGAAGCCTCCAAGAAGGTTGATGCCGTTTTGTTAGGTGCTGTGGGTGGTCCTAAATGGGGTACCGGTAGTGTTAGACCTGAACAAGGTTTACTAAAAATCCGTAAAGAACTTCAATTGTACGCCAACTTAAGACCATGTAACTTTGCATCCGACTCTCTTTTAGACTTATCTCCAATCAAGCCACAATTTGCTAAAGGTACTGACTTCGTTGTTGTCAGAGAATTAGTGGGAGGTATTTACTTTGGTAAGAGAAAGGAAGACGATGGTGATGGTGTCGCTTGGGATAGTGAACAATACACCGTTCCAGAAGTGCAAAGAATCACAAGAATGGCCGCTTTCATGGCCCTACAACATGAGCCACCATTGCCTATTTGGTCCTTGGATAAAGCTAATGTTTTGGCCTCTTCAAGATTATGGAGAAAAACTGTGGAGGAAACCATCAAGAACGAATTCCCTACATTGAAGGTTCAACATCAATTGATTGATTCTGCCGCCATGATCCTAGTTAAGAACCCAACCCACCTAAATGGTATTATAATCACCAGCAACATGTTTGGTGATATCATCTCCGATGAAGCCTCCGTTATCCCAGGTTCCTTGGGTTTGTTGCCATCTGCGTCCTTGGCCTCTTTGCCAGACAAGAACACCGCATTTGGTTTGTACGAACCATGCCACGGTTCTGCTCCAGATTTGCCAAAGAATAAGGTCAACCCTATCGCCACTATCTTGTCTGCTGCAATGATGTTGAAATTGTCATTGAACTTGCCTGAAGAAGGTAAGGCCATTGAAGATGCAGTTAAAAAGGTTTTGGATGCAGGTATCAGAACTGGTGATTTAGGTGGTTCCAACAGTACCACGGAAGTCGGTGATGCTGTCGCCGAAGAAGTTAAGAAAATCCTTGCTTAA","protein_sequence":"MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYTVPEVQRITRMAAFMALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPTHLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLPKNKVNPIATILSAAMMLKLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEVKKILA"},{"created_at":"2011-05-27T02:13:35.000Z","updated_at":"2011-07-22T17:53:47.000Z","name":"Trans-aconitate 3-methyltransferase","uniprot_id":"P32643","uniprot_name":"TMT1_YEAST","enzyme":true,"transporter":false,"gene_name":"TMT1","num_residues":299,"molecular_weight":"34768.0","theoretical_pi":"6.18","general_function":"Involved in methyltransferase activity","specific_function":"Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation","reactions":[{"id":1181,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2014,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2663,"direction":"\u003e","locations":"Cytoplasm","altext":"S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U18922","genbank_protein_id":"603416","gene_card_id":"TMT1","chromosome_location":"chromosome 5","locus":"YER175C","synonyms":[],"enzyme_classes":["2.1.1.145"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Methyltransf_11","identifier":"PF08241"}],"pathways":[],"gene_sequence":"ATGTCTACCTTTTCTGCTTCTGATTTCAACTCAGAAAGATATTCATCTTCAAGACCTTCTTATCCCTCCGATTTTTACAAGATGATTGATGAATACCACGACGGAGAAAGGAAATTACTCGTAGATGTTGGCTGTGGACCAGGTACTGCCACTTTACAAATGGCTCAGGAGTTAAAACCATTCGAACAAATTATCGGAAGCGATCTCTCCGCTACCATGATTAAGACTGCAGAAGTAATAAAGGAAGGAAGTCCTGATACATACAAAAACGTTTCATTTAAGATTTCTTCAAGTGATGATTTTAAATTCCTAGGCGCGGATTCAGTAGACAAACAGAAAATTGATATGATTACCGCAGTAGAATGTGCTCATTGGTTCGATTTCGAAAAATTTCAGCGATCTGCTTATGCCAATTTGAGAAAAGATGGTACTATCGCTATTTGGGGTTATGCGGACCCAATTTTCCCGGACTACCCTGAATTTGATGATCTGATGATTGAAGTTCCTTACGGGAAGCAAGGACTGGGACCCTATTGGGAACAACCGGGGAGATCTCGCCTTCGTAATATGCTGAAAGACTCTCACTTAGACCCAGAACTTTTCCATGATATACAAGTTTCATATTTTTGTGCAGAAGATGTGAGAGACAAAGTAAAACTCCACCAGCATACAAAGAAGCCATTGCTAATCAGAAAGCAGGTCACCCTAGTGGAGTTTGCAGATTATGTCAGAACCTGGAGCGCTTACCATCAGTGGAAGCAGGATCCAAAGAACAAAGATAAAGAAGATGTAGCAGATTGGTTTATTAAAGAGTCACTAAGGAGGAGGCCGGAACTTTCCACCAACACCAAAATTGAAGTTGTTTGGAATACTTTTTACAAACTTGGCAAAAGGGTCTGA","protein_sequence":"MSTFSASDFNSERYSSSRPSYPSDFYKMIDEYHDGERKLLVDVGCGPGTATLQMAQELKPFEQIIGSDLSATMIKTAEVIKEGSPDTYKNVSFKISSSDDFKFLGADSVDKQKIDMITAVECAHWFDFEKFQRSAYANLRKDGTIAIWGYADPIFPDYPEFDDLMIEVPYGKQGLGPYWEQPGRSRLRNMLKDSHLDPELFHDIQVSYFCAEDVRDKVKLHQHTKKPLLIRKQVTLVEFADYVRTWSAYHQWKQDPKNKDKEDVADWFIKESLRRRPELSTNTKIEVVWNTFYKLGKRV"}]}