{"ymdb_id":"YMDB00360","created_at":"2011-05-29T18:09:35.000Z","updated_at":"2016-09-08T18:35:23.000Z","name":"Adenosine diphosphate ribose","cas":"20762-30-5","state":"Solid","melting_point":"","description":"Adenosine diphosphate ribose (ADP-D-ribose) is a molecule formed into chains by the enzyme poly-ADP-ribose polymerase. It binds to and activates the TRPM2 ion channel.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"nucleus;cytoplasm","synthesis_reference":null,"chebi_id":"16960","hmdb_id":"HMDB01178","kegg_id":"C00301","pubchem_id":"192","cs_id":"187","foodb_id":null,"wikipedia_link":"Adenosine_diphosphate_ribose","biocyc_id":"ADENOSINE_DIPHOSPHATE_RIBOSE","iupac":"{[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}({hydroxy[(3,4,5-trihydroxyoxolan-2-yl)methoxy]phosphoryl}oxy)phosphinic acid","traditional_iupac":"adp ribose","logp":"-6.682939690657052","pka":"2.671027389204468","alogps_solubility":"3.61e+00 g/l","alogps_logp":"-1.80","alogps_logs":"-2.19","acceptor_count":"15","donor_count":"8","rotatable_bond_count":"9","polar_surface_area":"291.5199999999999","refractivity":"111.12329999999997","polarizability":"46.74695058468576","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"4.996693393052916","pka_strongest_acidic":"1.8574331410668954","bioavailability":"0","number_of_rings":"4","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["(Rib5)ppA","[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [hydroxy-[(3,4,5-trihydroxyoxolan-2-yl)methoxy]phosphoryl] hydrogen phosphate","5-(Adenosine 5'-pyrophosphoryl)-D-ribose","A5'pp5Rib","Adenosine 5'-diphosphoribose","Adenosine diphosphate ribose","AdoPPRib","ADP Ribose","ADP-D-ribose","ADP-Rib","ADP-ribose","ADPribose","Ribose adenosine diphosphate"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."}],"proteins":[{"created_at":"2011-05-24T20:45:21.000Z","updated_at":"2011-05-27T14:56:01.000Z","name":"ADP-ribose 1''-phosphate phosphatase","uniprot_id":"P38218","uniprot_name":"POA1_YEAST","enzyme":true,"transporter":false,"gene_name":"POA1","num_residues":177,"molecular_weight":"19937.59961","theoretical_pi":"7.77","general_function":"Involved in phosphatase activity","specific_function":"Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing","reactions":[{"id":2341,"direction":"\u003e","locations":"","altext":"ADP-ribose 1''-phosphate + H(2)O = ADP-ribose + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557705","genbank_protein_id":"45269301","gene_card_id":"POA1","chromosome_location":"chromosome 2","locus":"YBR022W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[{"name":"Macro","identifier":"PF01661"}],"pathways":[],"gene_sequence":"ATGTCGAACATCACTTATGTCAAAGGTAACATCTTAAAACCAAAGTCATATGCTAGGATCCTCATCCATTCTTGCAACTGCAATGGCTCGTGGGGTGGTGGGATCGCTTATCAACTTGCTTTGCGCTACCCAAAAGCAGAGAAAGATTACGTTGAAGTATGCGAAAAGTATGGTTCTAATTTACTAGGCAAATGCATATTACTTCCCAGTTACGAAAACTCAGATCTGCTGATTTGTTGCTTGTTTACATCATCATTTGGAGGTTCAAGTCATGGAGAAAAGCAAAGTATTTTGAATTATACAAAACTTGCTTTAGATAAATTGAAGACCTTTAGAGAAGCAAAAGACAAAACTCGAACAAGTGAAGATTCAATCGGTGACTATTTAAACGGCCACATCAAATACCCAATAGGGGAATATAAATTGGAAATGCCACAGATAAATAGTGGCATATTCGGAGTCCCTTGGAAAGAGACAGAACGCGTGTTAGAAGAATTTAGTGGCGACATGAGTTTTACAGTATATCAGCTGTAA","protein_sequence":"MSNITYVKGNILKPKSYARILIHSCNCNGSWGGGIAYQLALRYPKAEKDYVEVCEKYGSNLLGKCILLPSYENSDLLICCLFTSSFGGSSHGEKQSILNYTKLALDKLKTFREAKDKTRTSEDSIGDYLNGHIKYPIGEYKLEMPQINSGIFGVPWKETERVLEEFSGDMSFTVYQL"},{"created_at":"2011-05-24T20:45:44.000Z","updated_at":"2011-05-24T20:45:44.000Z","name":"Probable ADP-ribose 1''-phosphate phosphatase YML087W","uniprot_id":"Q04299","uniprot_name":"YMX7_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":284,"molecular_weight":"32067.0","theoretical_pi":"7.56","general_function":"Involved in phosphatase activity","specific_function":"Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing","reactions":[{"id":2341,"direction":"\u003e","locations":"","altext":"ADP-ribose 1''-phosphate + H(2)O = ADP-ribose + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1TXZ","cellular_location":null,"genbank_gene_id":"AY558403","genbank_protein_id":"45270696","gene_card_id":null,"chromosome_location":null,"locus":"YMR087W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[],"pathways":[],"gene_sequence":"ATGACAGGATCTTTAAACAGACACTCACTTTTGAACGGGGTAAAAAAAATGAGAATAATATTATGCGATACAAACGAAGTAGTTACCAATCTCTGGCAGGAATCTATACCCCATGCATATATTCAAAATGATAAGTATCTTTGTATTCATCATGGGCACCTTCAATCTCTTATGGATTCAATGCGTAAAGGTGATGCAATCCATCATGGCCACTCTTACGCAATTGTTTCACCTGGTAACTCGTATGGCTATCTTGGAGGAGGGTTCGATAAAGCTTTGTATAATTATTTCGGGGGAAAGCCCTTTGAAACATGGTTCAGGAATCAGCTTGGAGGAAGATATCACACGGTCGGATCTGCTACAGTGGTTGACCTACAGCGATGTCTTGAAGAGAAAACAATTGAATGTAGAGATGGTATTAGGTATATTATTCATGTTCCGACCGTTGTAGCCCCATCAGCTCCTATATTTAATCCGCAGAATCCCCTCAAGACAGGGTTTGAACCGGTTTTCAACGCCATGTGGAATGCCTTGATGCATTCTCCAAAAGACATTGATGGTCTTATTATTCCTGGATTATGTACTGGGTATGCAGGTGTACCACCCATTATCAGTTGCAAGAGTATGGCCTTTGCGTTAAGACTATATATGGCGGGAGATCACATAAGCAAAGAATTGAAAAATGTGCTGATCATGTATTATTTGCAATATCCGTTTGAACCTTTTTTCCCGGAAAGTTGCAAAATAGAGTGCCAAAAACTAGGAATAGATATCGAAATGCTGAAATCCTTTAATGTAGAAAAAGATGCAATAGAATTGCTCATTCCTAGAAGGATTTTGACCTTGGATTTATAA","protein_sequence":"MTGSLNRHSLLNGVKKMRIILCDTNEVVTNLWQESIPHAYIQNDKYLCIHHGHLQSLMDSMRKGDAIHHGHSYAIVSPGNSYGYLGGGFDKALYNYFGGKPFETWFRNQLGGRYHTVGSATVVDLQRCLEEKTIECRDGIRYIIHVPTVVAPSAPIFNPQNPLKTGFEPVFNAMWNALMHSPKDIDGLIIPGLCTGYAGVPPIISCKSMAFALRLYMAGDHISKELKNVLIMYYLQYPFEPFFPESCKIECQKLGIDIEMLKSFNVEKDAIELLIPRRILTLDL"},{"created_at":"2011-05-26T19:13:08.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"ADP-ribose pyrophosphatase","uniprot_id":"Q01976","uniprot_name":"ADPP_YEAST","enzyme":true,"transporter":false,"gene_name":"YSA1","num_residues":231,"molecular_weight":"26086.80078","theoretical_pi":"6.3","general_function":"Involved in hydrolase activity","specific_function":"ADP-ribose + H(2)O = AMP + D-ribose 5- phosphate","reactions":[{"id":2562,"direction":"\u003e","locations":"Cytoplasmic","altext":"ADP-ribose + H(2)O = AMP + D-ribose 5-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"AY558185","genbank_protein_id":"45270260","gene_card_id":"YSA1","chromosome_location":"chromosome 2","locus":"YBR111C","synonyms":["ADP-ribose diphosphatase","ADP-ribose phosphohydrolase","Adenosine diphosphoribose pyrophosphatase","ADPR-PPase"],"enzyme_classes":["3.6.1.13"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"NUDIX","identifier":"PF00293"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGTTTTTGAGAAACGTAAGAGTTATTTCCCTCAATTCAAGGAGACTATTTAGAACTATGAGCACCGTCAAGGGTAAACCAGAAGATGCTAAAATAATTGAAGCCCGTCACGTTAAAGAAACATCTGACTGCAAGTGGATCGGTTTACAAAAAATCATCTACAAAGATCCCAACGGGAAGGAAAGGGAATGGGATAGCGCAGTCCGCACCACTAGAAGTTCCGGTGGTGTAGACGGCATTGGTATCTTAACCATTCTAAAATACAAAGATGGAAAACCTGATGAAATTTTGCTACAAAAGCAGTTTCGCCCTCCCGTTGAGGGCGTATGCATTGAGATGCCAGCCGGTTTGATAGATGCGGGTGAAGATATTGACACTGCTGCCTTAAGAGAATTAAAAGAAGAGACTGGTTACAGTGGTAAAATAATTTCTAAAAGCCCAACAGTTTTTAACGATCCTGGTTTCACAAACACCAACCTCTGTCTGGTTACTGTCGAAGTTGATATGAGTTTACCTGAAAACCAAAAACCAGTTACTCAATTGGAAGATAATGAATTTATCGAATGCTTTAGCGTTGAGTTGCACAAGTTTCCTGATGAAATGGTTAAGTTGGATCAACAAGGCTACAAGTTGGATGCACGTGTTCAAAACGTAGCTCAAGGTATCCTCATGGCCAAGCAATACCACATCAAATAG","protein_sequence":"MFLRNVRVISLNSRRLFRTMSTVKGKPEDAKIIEARHVKETSDCKWIGLQKIIYKDPNGKEREWDSAVRTTRSSGGVDGIGILTILKYKDGKPDEILLQKQFRPPVEGVCIEMPAGLIDAGEDIDTAALRELKEETGYSGKIISKSPTVFNDPGFTNTNLCLVTVEVDMSLPENQKPVTQLEDNEFIECFSVELHKFPDEMVKLDQQGYKLDARVQNVAQGILMAKQYHIK"}]}