{"ymdb_id":"YMDB00347","created_at":"2011-05-29T18:08:15.000Z","updated_at":"2016-09-08T18:35:22.000Z","name":"S-Methyl-L-methionine","cas":"4727-40-6","state":"Solid","melting_point":"139 oC ","description":"S-Methylmethionine is a derivative of methionine. This cation is an intermediate in many biosynthetic pathways owing to the sulfonium functional group. The natural derivative S-methylmethionine is biosynthesized from L-methionine which is first converted to S-adenosylmethionine. The subsequent conversion, involving replacement of the adenosyl group by a methyl group is catalyzed by the enzyme methionine S-methyltransferase. S-Methylmethionine is particularly abundant in plants, being more abundant than methionine. [Wikipedia]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"extracellular;cytoplasm","synthesis_reference":null,"chebi_id":"17728","hmdb_id":null,"kegg_id":"C03172","pubchem_id":"145692","cs_id":null,"foodb_id":null,"wikipedia_link":"S-Methylmethionine","biocyc_id":null,"iupac":"[(3S)-3-amino-3-carboxypropyl]dimethylsulfanium","traditional_iupac":"S-methyl-L-methionine","logp":"-3.3250557102888223","pka":null,"alogps_solubility":"8.12e+00 g/l","alogps_logp":"-1.27","alogps_logs":"-1.39","acceptor_count":"3","donor_count":"2","rotatable_bond_count":"4","polar_surface_area":"63.32","refractivity":"41.09740000000001","polarizability":"17.560186093756815","formal_charge":"1","physiological_charge":"1","pka_strongest_basic":"9.414777499242314","pka_strongest_acidic":"2.236989607571266","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["S-Methyl-L-methionine"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-27T03:41:09.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Homocysteine S-methyltransferase 1","uniprot_id":"Q12525","uniprot_name":"MHT1_YEAST","enzyme":true,"transporter":false,"gene_name":"MHT1","num_residues":324,"molecular_weight":"36714.5","theoretical_pi":"5.26","general_function":"Involved in homocysteine S-methyltransferase activity","specific_function":"Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine","reactions":[{"id":1637,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2739,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"S-methyl-L-methionine + L-homocysteine = 2 L-methionine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY558194","genbank_protein_id":"45270278","gene_card_id":"MHT1","chromosome_location":"chromosome 12","locus":"YLL062C","synonyms":["S-methylmethionine:homocysteine methyltransferase 1","SMM:Hcy S-methyltransferase 1"],"enzyme_classes":["2.1.1.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" homocysteine S-methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"S-methyl_trans","identifier":"PF02574"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"gene_sequence":"ATGAAGCGCATTCCAATCAAAGAACTAATAGTTGAGCACCCCGGAAAAGTTCTTATCCTTGATGGTGGACAGGGTACAGAATTGGAAAACAGAGGCATTAACATAAATAGTCCGGTATGGTCTGCAGCTCCTTTTACGAGCGAATCCTTTTGGGAGCCATCTTCTCAAGAGCGAAAGGTGGTAGAAGAAATGTACAGAGACTTTATGATTGCTGGCGCAAACATATTAATGACAATTACTTACCAGGCAAACTTTCAAAGCATATCTGAGAATACCTCGATTAAAACTCTGGCTGCTTACAAGCGTTTTCTCGATAAAATCGTGTCATTTACTCGTGAATTTATTGGTGAGGAAAGGTACTTAATCGGGAGTATTGGCCCATGGGCAGCACATGTATCCTGTGAATATACTGGTGACTATGGTCCCCATCCTGAGAATATTGATTACTACGGCTTTTTCAAACCCCAGCTGGAGAACTTCAACCAAAATAGAGATATTGATCTTATTGGTTTTGAAACGATTCCAAATTTTCATGAGTTAAAGGCTATTTTATCCTGGGATGAAGATATTATTTCGAAGCCCTTTTATATTGGGTTGTCGGTGGATGACAATAGTTTGCTACGAGACGGTACCACTTTGGAAGAAATTTCTGTCCATATAAAAGGCCTCGGAAATAAAATTAACAAGAATCTCTTATTAATGGGAGTTAACTGTGTCAGTTTCAATCAATCGGCATTAATTCTTAAAATGTTGCACGAGCATCTACCTGGCATGCCTCTGCTAGTTTACCCAAACAGTGGAGAAATCTACAATCCCAAAGAGAAGACATGGCACCGGCCGACTAATAAGTTGGATGACTGGGAGACCACGGTTAAGAAATTCGTTGATAATGGTGCGCGCATTATTGGCGGTTGTTGTAGAACGTCTCCTAAAGATATCGCCGAAATTGCATCAGCTGTAGATAAATACTCCTAA","protein_sequence":"MKRIPIKELIVEHPGKVLILDGGQGTELENRGININSPVWSAAPFTSESFWEPSSQERKVVEEMYRDFMIAGANILMTITYQANFQSISENTSIKTLAAYKRFLDKIVSFTREFIGEERYLIGSIGPWAAHVSCEYTGDYGPHPENIDYYGFFKPQLENFNQNRDIDLIGFETIPNFHELKAILSWDEDIISKPFYIGLSVDDNSLLRDGTTLEEISVHIKGLGNKINKNLLLMGVNCVSFNQSALILKMLHEHLPGMPLLVYPNSGEIYNPKEKTWHRPTNKLDDWETTVKKFVDNGARIIGGCCRTSPKDIAEIASAVDKYS"},{"created_at":"2011-05-27T03:42:09.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Homocysteine S-methyltransferase 2","uniprot_id":"Q08985","uniprot_name":"SAM4_YEAST","enzyme":true,"transporter":false,"gene_name":"SAM4","num_residues":325,"molecular_weight":"36668.19922","theoretical_pi":"4.88","general_function":"Involved in homocysteine S-methyltransferase activity","specific_function":"Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine","reactions":[{"id":1637,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2739,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"S-methyl-L-methionine + L-homocysteine = 2 L-methionine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"Z73629","genbank_protein_id":"1370563","gene_card_id":"SAM4","chromosome_location":"chromosome 16","locus":"YPL273W","synonyms":["S-adenosylmethionine metabolism protein 4","S-methylmethionine:homocysteine methyltransferase 2","SMM:Hcy S-methyltransferase 2"],"enzyme_classes":["2.1.1.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" homocysteine S-methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"S-methyl_trans","identifier":"PF02574"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"gene_sequence":"ATGGCACGTCTTCCTCTAAAGCAGTTCTTAGCGGATAACCCCAAAAAAGTTCTTGTTCTTGACGGTGGTCAAGGAACAGAACTGGAAAACAGAGGTATCAAAGTTGCAAATCCCGTGTGGTCTACTATTCCATTTATTAGCGAATCATTTTGGTCTGATGAGTCATCTGCTAACAGAAAAATTGTCAAAGAAATGTTCAACGATTTCTTGAATGCTGGCGCAGAAATATTGATGACTACAACATACCAAACGAGTTATAAATCAGTTTCTGAAAACACCCCAATCAGAACTTTATCCGAGTACAATAACCTTTTAAACAGGATTGTCGATTTTTCTCGTAATTGTATTGGCGAAGACAAATATTTGATTGGCTGTATTGGCCCATGGGGTGCTCATATTTGTCGTGAGTTTACAGGCGACTATGGTGCTGAGCCAGAAAATATTGATTTCTACCAATACTTCAAGCCTCAGTTGGAGAATTTCAATAAAAATGACAAATTGGATTTGATTGGGTTTGAAACCATTCCTAACATCCATGAACTGAAAGCTATCTTATCTTGGGATGAGAGTATCCTGTCTAGACCCTTCTATATCGGGTTGTCTGTGCATGAGCACGGTGTCTTGAGAGACGGCACTACCATGGAAGAAATCGCACAAGTTATTAAGGACTTGGGCGACAAAATAAATCCTAACTTCTCGTTCTTAGGAATCAACTGCGTCAGCTTCAACCAATCACCCGACATTCTTGAGTCTCTACATCAAGCACTACCAAATATGGCCTTGCTTGCTTATCCAAACAGTGGTGAAGTTTATGATACTGAAAAGAAGATATGGTTGCCAAATAGCGATAAGCTGAACAGTTGGGATACGGTTGTTAAACAGTACATTAGCAGCGGTGCCCGTATCATTGGTGGTTGTTGCAGAACAAGTCCAAAAGACATCCAAGAGATTTCTGCAGCCGTCAAGAAATACACGTAA","protein_sequence":"MARLPLKQFLADNPKKVLVLDGGQGTELENRGIKVANPVWSTIPFISESFWSDESSANRKIVKEMFNDFLNAGAEILMTTTYQTSYKSVSENTPIRTLSEYNNLLNRIVDFSRNCIGEDKYLIGCIGPWGAHICREFTGDYGAEPENIDFYQYFKPQLENFNKNDKLDLIGFETIPNIHELKAILSWDESILSRPFYIGLSVHEHGVLRDGTTMEEIAQVIKDLGDKINPNFSFLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWDTVVKQYISSGARIIGGCCRTSPKDIQEISAAVKKYT"},{"created_at":"2011-05-27T07:01:07.000Z","updated_at":"2011-06-05T02:55:31.000Z","name":"S-methylmethionine permease 1","uniprot_id":"Q12372","uniprot_name":"MMP1_YEAST","enzyme":false,"transporter":true,"gene_name":"MMP1","num_residues":583,"molecular_weight":"64217.0","theoretical_pi":"7.97","general_function":"Involved in transport","specific_function":"High-affinity S-methylmethionine (SMM) permease, required for utilization of S-methylmethionine as a sulfur source","reactions":[],"signal_regions":"None","transmembrane_regions":"78-96;102-123;144-164;183-203;216-236;255-274;299-319;357-377;403-423;429-449;474-494;506-526","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein. Endoplasmic reticulum","genbank_gene_id":"Z47973","genbank_protein_id":"642323","gene_card_id":"MMP1","chromosome_location":"chromosome 12","locus":"YLL061W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGATGAATTTGAATCTACCAAACTTTCGAAGGTTCAGTTTTCCACTAGCGTGTTAAGTACGCCTTCGAATGAAGGAAATAATCTAATACACAGATTCAAGAACTCTTTCAAGCGAAATGATTCACCAGCGATCCAAGAAGGTTTGCTGTATTCGGAGCTTTCAGAGGAAGAAAAAATACAATGGGACTTAGCCAACCAGCCGTATAAAAAGGTCCTAGATCAAAGACACCTGACCATGATAGCCATTGGAGGTACTCTAGGGACGGGTCTTTTCATTGGTTTAGGGGAATCACTAGCGTCCGGACCTGCTTCTTTGCTAATTGGTTTCTTGTTGGTCGGCGCATCTATGCTCTGTGTTGTTCAGTGTGGGGCCGAACTTTCATGTCAGTACCCTGTTTCCGGCTCCTATGCGCTGCACGCCAGTAGATTTATAGACCCATCAGTCGGCTTCAGTATAGGAATTAACTACTTATTGATGTGGCTCATATCTTACCCTAGCGAGCTGGTAGGATGTTCGCTTACCATCTCTTATTGGGCACCATCGGTCAATCCTGCTGCCTGGGTTGCAATCGCGTTCGTTTTAAGCATGCTATTGAATCTTTTTGGGGCAAGAGGCTTTGCAGAATCAGAGTTTTATATGTCAATTTTCAAAATTGTGGCTCTATTCATTTTTATAATTATTGGTATTGTTCTCATTGCAGGTGGTGGGCCTGATTCTACTGGATACATCGGCACGAAGTATTGGCACGATCCAGGCTCCTTCGCTGTTCCTGTTTTCAAAAACCTCTGCAATACTTTTGTTTCGGCAGCATACTCCTTTAGTGGTACAGAAATGGTTGTTTTAACCAGCACTGAAGCAAGGAGTGTTTCCTCAGTCTCTCGGGCAGCGAAAGGTACGTTCTGGAGAATTATCATCTTTTATATTGTTACAGTGATTATAATTGGTTGCCTGGTCCCTTATAATGATCCTCGTCTGATTAGCGGTTCATCCAGTGAGGATATTACTGCTTCCCCGTTTGTTATTGCCTTGAGCAATACTGGTGCTATGGGAACAAGAGTGTCTCATTTTATGAATGCGGTCATCTTGATAGCCGTATTTTCTGTTTGCAATTCCTGCGTTTACGCATCCTCTAGATTGATTCAGGGTTTGGCGACAGCAGGCCAACTTCCAAAGATCTGCGCTTACATGGACAGGAATGGTCGGCCTTTAGTTGGCATGGCTATATGTGGCGCTTTTGGATTGTTAGGCTTTTTGGTTGTTTCCAAGAACCAGGGTACAGTTTTCACATGGTTGTTTGCGTTGTGTTCCATTTCATTTTTCACAACTTGGTTCTGTATTTGCTTCTGTCAAGTCAGATTTAGGATGGCAATGAAAGCTCAAGGAAGGTCAAAGGATGACATTATCTATAGATCGACATTAGGGATATACGGAGGAATTTTCGGCTGTATCTTAAATGTTCTATTGGTAATTGGAGAAATATATGTATCGGCTGCACCCGTGGGTAGTCCCAGTTCTGCTGCTAATTTCTTTGAATATTGTATGAGTATTCCCATAATGATTGCTGTATATATTGGCCATAGAATTTACCGCAGAGACTGGAGACACTGGTACATCAAGCGGATGGATATTGACCTCGATAGCGGACATTCGTTAGAGGACTTCGAAGCCACCAAGCTTGAGAGGGATGAGGATAAGAAATACGTTTCCTCTAAGCCACTTTACTATAGGATCTATCGGTTTTTCTGTTAA","protein_sequence":"MDEFESTKLSKVQFSTSVLSTPSNEGNNLIHRFKNSFKRNDSPAIQEGLLYSELSEEEKIQWDLANQPYKKVLDQRHLTMIAIGGTLGTGLFIGLGESLASGPASLLIGFLLVGASMLCVVQCGAELSCQYPVSGSYALHASRFIDPSVGFSIGINYLLMWLISYPSELVGCSLTISYWAPSVNPAAWVAIAFVLSMLLNLFGARGFAESEFYMSIFKIVALFIFIIIGIVLIAGGGPDSTGYIGTKYWHDPGSFAVPVFKNLCNTFVSAAYSFSGTEMVVLTSTEARSVSSVSRAAKGTFWRIIIFYIVTVIIIGCLVPYNDPRLISGSSSEDITASPFVIALSNTGAMGTRVSHFMNAVILIAVFSVCNSCVYASSRLIQGLATAGQLPKICAYMDRNGRPLVGMAICGAFGLLGFLVVSKNQGTVFTWLFALCSISFFTTWFCICFCQVRFRMAMKAQGRSKDDIIYRSTLGIYGGIFGCILNVLLVIGEIYVSAAPVGSPSSAANFFEYCMSIPIMIAVYIGHRIYRRDWRHWYIKRMDIDLDSGHSLEDFEATKLERDEDKKYVSSKPLYYRIYRFFC"}]}