{"ymdb_id":"YMDB00330","created_at":"2011-05-29T18:06:52.000Z","updated_at":"2016-10-18T17:11:26.000Z","name":"L-Lysine","cas":"56-87-1","state":"Solid","melting_point":"224.5 oC","description":"Lysine (abbreviated as Lys or K) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a polar, basic amino acid, because of the positively charged nature of the amino-alkyl side chain. In yeast, lysine is synthesized from aspartic acid (aspartate).  Specifically, L-aspartate is first converted to L-aspartyl-4-phosphate by aspartokinase (or Aspartate kinase). Subsequently, beta-aspartate semialdehyde dehydrogenase converts this into beta-aspartyl-4-semialdehyde (or beta-aspartate-4-semialdehyde) through an NADH-dependent reaction.  After this step, Dihydrodipicolinate synthase adds a pyruvate group to the beta-aspartyl-4-semialdehyde, and two water molecules are removed. This causes cyclization and gives rise to 2,3-dihydrodipicolinate.  This product is reduced to 2,3,4,5-tetrahydrodipicolinate by dihydrodipicolinate reductase. Tetrahydrodipicolinate N-acetyltransferase opens this ring and gives rise to N-succinyl-L-2-amino-6-oxoheptanedionate (or N-acyl-2-amino-6-oxopimelate). N-succinyl-L-2-amino-6-oxoheptanedionate is converted into N-succinyl-LL-2,6-diaminoheptanedionate (N-acyl-2,6-diaminopimelate). This reaction is catalyzed by the enzyme succinyl diaminopimelate aminotransferase. A glutaric acid molecule is used in this reaction and an oxoacid is produced as a byproduct. N-succinyl-LL-2,6-diaminoheptanedionate (N-acyl-2,6-diaminopimelate)is converted into LL-2,6-diaminoheptanedionate (L,L-2,6-diaminopimelate) by succinyl diaminopimelate desuccinylase (acyldiaminopimelate deacylase). A water molecule is consumed in this reaction and a succinate is produced a byproduct. LL-2,6-diaminoheptanedionate is converted by diaminopimelate epimerase into meso-2,6-diamino-heptanedionate (meso-2,6-diaminopimelate). Finally meso-2,6-diamino-heptanedionate is converted into L-lysine by diaminopimelate decarboxylase. Lysine catabolism is unusual in the way that the ε-amino group is transferred to alpha-ketoglutarate and into the general nitrogen pool. The reaction is a transamination in which the ε-amino group is transferred to the alpha-keto carbon of alpha-ketoglutarate forming the metabolite, saccharopine. Saccharopine is immediately hydrolyzed by the enzyme alpha-aminoadipic semialdehyde synthase in such a way that the amino nitrogen remains with the alpha-carbon of alpha-ketoglutarate, producing glutamate and alpha-aminoadipic semialdehyde. The ultimate end-product of lysine catabolism is acetoacetyl-CoA.","experimental_water_solubility":"1000 mg/mL at 20 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-3.05 [HANSCH,C ET AL. (1995)]","location":"extracellular;mitochondrion;vacuole;cytoplasm","synthesis_reference":"Rothstein, Morton. DL-Lysine-6-C14 and DL-a-aminoadipic acid-6-C14. Biochemical Preparations (1961), 8 85-8.","chebi_id":"18019","hmdb_id":"HMDB00182","kegg_id":"C00047","pubchem_id":"5962","cs_id":"5747","foodb_id":null,"wikipedia_link":"Lysine","biocyc_id":"LYS","iupac":"(2S)-2,6-diaminohexanoic acid","traditional_iupac":"L-lysine","logp":"-3.2145347205442243","pka":null,"alogps_solubility":"1.05e+02 g/l","alogps_logp":"-3.76","alogps_logs":"-0.14","acceptor_count":"4","donor_count":"3","rotatable_bond_count":"5","polar_surface_area":"89.34","refractivity":"37.8095","polarizability":"15.843749178427787","formal_charge":"0","physiological_charge":"1","pka_strongest_basic":"10.288061623041543","pka_strongest_acidic":"2.7382862451337","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(+)-S-Lysine","(S)-2,6-diamino-Hexanoate","(S)-2,6-diamino-Hexanoic acid","(S)-2,6-Diaminohexanoate","(S)-2,6-Diaminohexanoic acid","(S)-a,e-Diaminocaproate","(S)-a,e-Diaminocaproic acid","(S)-Lysine","2,6-Diaminohexanoate","2,6-Diaminohexanoic acid","6-amino-Aminutrin","6-amino-L-Norleucine","a-Lysine","alpha-Lysine","Aminutrin","h-Lys-oh","L-(+)-Lysine","L-2,6-Diainohexanoate","L-2,6-Diainohexanoic acid","L-2,6-Diaminocaproate","L-2,6-Diaminocaproic acid","L-Lys","Lys","Lysine","Lysine acid"],"pathways":[{"name":"Biotin metabolism","kegg_map_id":"00780"},{"name":"Lysine degradation","kegg_map_id":"00310"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"lysine metabolism","kegg_map_id":null}],"growth_conditions":[{"growth_media":"YPD media","concentration":"701.65128","concentration_units":"\u0026#181;M","error":"13.97949"},{"growth_media":"YPG media","concentration":"561.26154","concentration_units":"\u0026#181;M","error":"11.30256"},{"growth_media":"SD media","concentration":"350.67692","concentration_units":"\u0026#181;M","error":"7.13846"},{"growth_media":"SG media","concentration":"420.87179","concentration_units":"\u0026#181;M","error":"8.32821"},{"growth_media":"M (molasses)","concentration":"350.67692","concentration_units":"\u0026#181;M","error":"7.13846"},{"growth_media":"MA (molasses)","concentration":"842.04103","concentration_units":"\u0026#181;M","error":"16.95385"},{"growth_media":"MB (molasses)","concentration":"280.77949","concentration_units":"\u0026#181;M","error":"5.65128"},{"growth_media":"MAB (molasses)","concentration":"771.84615","concentration_units":"\u0026#181;M","error":"15.46667"},{"growth_media":"YEB media with 0.5 mM glucose","concentration":"3620.0","concentration_units":"\u0026#181;M","error":"181.0"},{"growth_media":"Synthetic medium with 20 g/L glucose","concentration":"1860.0","concentration_units":"\u0026#181;M","error":"683.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"4.1","concentration_units":"umol/g DW","error":"0.0"}],"references":[{"pubmed_id":7654310,"citation":"Martinez-Force, E., Benitez, T. (1995). \"Effects of varying media, temperature, and growth rates on the intracellular concentrations of yeast amino acids.\" Biotechnol Prog 11:386-392."},{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10509015,"citation":"Arevalo-Rodriguez, M., Calderon, I. L., Holmberg, S. (1999). \"Mutations that cause threonine sensitivity identify catalytic and regulatory regions of the aspartate kinase of Saccharomyces cerevisiae.\" Yeast 15:1331-1345."},{"pubmed_id":12584756,"citation":"Hans, M. A., Heinzle, E., Wittmann, C. (2003). \"Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.\" Biotechnol Bioeng 82:143-151."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T20:17:41.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Saccharopine dehydrogenase [NAD+, L-lysine-forming]","uniprot_id":"P38998","uniprot_name":"LYS1_YEAST","enzyme":true,"transporter":false,"gene_name":"LYS1","num_residues":373,"molecular_weight":"41464.39844","theoretical_pi":"9.56","general_function":"Involved in oxidoreductase activity","specific_function":"Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate","reactions":[{"id":1959,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2309,"direction":"\u003e","locations":"Cytoplasm","altext":"N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD(+) + H(2)O = L-lysine + 2-oxoglutarate + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":4179,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006478","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X77362","genbank_protein_id":"453184","gene_card_id":"LYS1","chromosome_location":"chromosome 9","locus":"YIR034C","synonyms":["SDH","Lysine--2-oxoglutarate reductase"],"enzyme_classes":["1.5.1.7","1.5.1.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"AlaDh_PNT_C","identifier":"PF01262"},{"name":"AlaDh_PNT_N","identifier":"PF05222"}],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Lysine degradation","kegg_map_id":"00310"},{"name":"lysine metabolism","kegg_map_id":null}],"gene_sequence":"ATGGCTGCCGTCACATTACATCTAAGAGCTGAAACTAAACCCCTAGAGGCACGTGCTGCCTTAACACCTACCACGGTTAAAAAACTGATAGCTAAGGGCTTCAAAATATATGTAGAGGACAGTCCACAATCTACTTTCAATATTAACGAATATCGTCAAGCAGGTGCCATTATAGTGCCTGCAGGTTCATGGAAAACCGCTCCACGCGACAGAATCATTATAGGTTTGAAGGAAATGCCTGAAACCGATACTTTCCCTCTAGTCCACGAACACATCCAGTTTGCTCACTGCTACAAAGACCAAGCTGGGTGGCAAAATGTCCTTATGAGATTTATTAAGGGACACGGTACTCTATATGATTTGGAATTTTTGGAAAATGACCAAGGTAGAAGAGTTGCTGCCTTTGGATTTTACGCTGGGTTCGCAGGTGCAGCCCTTGGTGTAAGAGACTGGGCATTCAAGCAAACGCATTCTGACGATGAAGACTTGCCTGCAGTGTCGCCTTACCCCAATGAAAAGGCGTTGGTTAAAGATGTTACCAAAGATTATAAAGAAGCCTTAGCCACCGGCGCCAGAAAGCCAACCGTGTTAATCATTGGTGCGCTAGGAAGATGTGGTTCCGGTGCCATCGATCTGTTGCACAAAGTTGGTATTCCAGATGCTAACATATTAAAATGGGATATCAAAGAAACTTCCCGTGGTGGTCCCTTTGACGAAATTCCACAAGCTGATATTTTCATCAATTGTATATATCTATCGAAGCCAATTGCTCCTTTCACTAACATGGAGAAACTGAATAATCCTAACAGAAGACTAAGGACCGTGGTGGACGTATCAGCAGACACTACCAACCCTCACAACCCCATCCCAATATACACTGTGGCTACTGTGTTTAACAAACCTACCGTTCTGGTACCTACCACTGTCGGGCCTAAATTATCTGTCATCTCTATTGATCACTTGCCTTCTTTGCTGCCAAGAGAAGCTTCAGAATTTTTCTCTCATGATCTTTTACCATCTTTAGAGCTCCTACCTCAAAGAAAAACTGCTCCTGTCTGGGTTAGAGCCAAGAAATTGTTCGATAGACATTGCGCTCGTGTTAAAAGATCTTCAAGATTGTAG","protein_sequence":"MAAVTLHLRAETKPLEARAALTPTTVKKLIAKGFKIYVEDSPQSTFNINEYRQAGAIIVPAGSWKTAPRDRIIIGLKEMPETDTFPLVHEHIQFAHCYKDQAGWQNVLMRFIKGHGTLYDLEFLENDQGRRVAAFGFYAGFAGAALGVRDWAFKQTHSDDEDLPAVSPYPNEKALVKDVTKDYKEALATGARKPTVLIIGALGRCGSGAIDLLHKVGIPDANILKWDIKETSRGGPFDEIPQADIFINCIYLSKPIAPFTNMEKLNNPNRRLRTVVDVSADTTNPHNPIPIYTVATVFNKPTVLVPTTAGPKLSVISIDHLPSLLPREASEFFSHDLLPSLELLPQRKTAPVWVRAKKLFDRHCARVKRSSRL"},{"created_at":"2011-05-26T19:04:24.000Z","updated_at":"2011-05-27T15:01:05.000Z","name":"Lysyl-tRNA synthetase, mitochondrial","uniprot_id":"P32048","uniprot_name":"SYKM_YEAST","enzyme":true,"transporter":false,"gene_name":"MSK1","num_residues":576,"molecular_weight":"66127.60156","theoretical_pi":"9.23","general_function":"Involved in nucleotide binding","specific_function":"ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)","reactions":[{"id":1719,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2561,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"X57360","genbank_protein_id":"450763","gene_card_id":"MSK1","chromosome_location":"chromosome 14","locus":"YNL073W","synonyms":["Lysine--tRNA ligase","LysRS"],"enzyme_classes":["6.1.1.6"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" lysine-tRNA ligase activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ligase activity"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" lysyl-tRNA aminoacylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"}],"pfams":[{"name":"tRNA-synt_2","identifier":"PF00152"},{"name":"tRNA_anti","identifier":"PF01336"}],"pathways":[],"gene_sequence":"ATGAATGTGCTGTTAAAAAGACGCAGTTTAACGTTTGCACCGAGATGGCTGTGGTGCAAGTGTCGAAGTAGCAGGAGCAGGCCGTATTCTCTGGCACACGCGGTCGACACAAGTAAGATGGAGGCAACCAGGAGGAACGGTCAGATTGTGAAGGACCTGGGTAGATACTATCCGTCAATGTCAGAATCAGCACTCCACGATCTTTGCCAGGAGTATAAAGAAGTCACTATCGCAGACTTTAATGAGAGATTCTTGGGCAACCCAGCCACATTACACCATGAGGATAATCCTAATTTGTTACTTAGTATTAATGGCAGGATTAAAAGCATTAGGTTTTCAGGCCAGAAGATTGTTTTTATAGATCTTTACAACGGCAGTAGCGGATTGAAGAATGATACGCAACTGCAGTTGATCGTAAACTACAATAAAATTGGTGGGAGTAGTGAGGATAAGGCGAATTTCTCAGAATATATGAACTTTTTGAAGAAAGGAGATTATATTAAGGCGCTCGGTTATCCCGGGTTTTCCCAATCCAGAGTCAAGATGCTGTCCTTGATATGTAATAAGCTACCTATAGTATTGTCTGTTTCGCAACTGCCGTTACCTTCCAGACTGAATGATGAAACCAAGATCAAATCTAATAGAGTTGTTGACTACCAATTAAACGGCACTCAGACACTGCTAGTAAGGGCGCGTATCATCAAACTTTTGAGGAAGTTTCTCGACGACAGAAACTTCGTTGAGGTTGAAACGCCTATACTGTCATCAAAGTCCAACGGTGCCATGGCGAAGCCCTTTATAACGTCGTCCAAGGACTTCGACCATTTGGAGTTGCGTATTGCACCAGAATTATGGCTGAAGAGGCTTATAATTAGTGGTTTACAAAAAGTATACGAAATAGGAAAGGTCTTTCGAAACGAAGGCATTGATTCCACGCATAATGCTGAGTTTTCCACTTTAGAATTCTATGAAACTTACATGTCAATGGACGATATAGTCACAAGGACTGAAGATTTGTTCAAATTTTTGATTACTAACTTGCAAAAGTTCTTTCAAGATACCCGTCTGCCTGTCCCTAAGACGTTTAGTGAATTACATCTGGCACTATCCGAGAATAATTGGAAGTTTAGAAAAGTCGAATTCCTGCCCACTTTGAACAAAGAGCTTGGCATTGATCTAATGAACTCTGGATTGGATATCAATAAGCCGAGCGAACTTTTGAAGGCTTTACCGAAAGACATTGCGAAGAAGTATTTTCCTTCTGCAGATAACACTGGGCAATTATCTTCGCTGCAAATCCTAAATAAACTATCGGACGTGTTCCTCGAGCAGCGCCATTGTCAATCAACCTTGCCTACGGTAATATACCATCAACCTGCAATATTATCGCCCTTAGCCAAGACGGATCCGCAAAATAAGCAAGTCACGAAGAGATTCGAAGTCTTCATCAAAGGTAAGGAATACATCAATGCTTACGAAGAGGAAAATTGCCCCCAATTACAACTGCAGAAGTTTCTACAACAAAAGCAGATTAACGAATTGACAGGAAACAAAACTGAGACCTTATCGCCTGTTATTGACTACCAGTATGTTGAGACGATGAAATACGGTATGCCTCCAGTAGGTGGCTTTGGCCTTGGCATAGATAGATTGTGCATGCTATTTTGCGACAAGAAGAGGATAGAAGAGGTTCTGCCCTTTGGCTGTGTGGATGATGTAAACAGGCAGTAA","protein_sequence":"MNVLLKRRSLTFAPRWLWCKCRSSRSRPYSLAHAVDTSKMEATRRNGQIVKDLGRYYPSMSESALHDLCQEYKEVTIADFNERFLGNPATLHHEDNPNLLLSINGRIKSIRFSGQKIVFIDLYNGSSGLKNDTQLQLIVNYNKIGGSSEDKANFSEYMNFLKKGDYIKALGYPGFSQSRVKMLSLICNKLPIVLSVSQLPLPSRLNDETKIKSNRVVDYQLNGTQTLLVRARIIKLLRKFLDDRNFVEVETPILSSKSNGAMAKPFITSSKDFDHLELRIAPELWLKRLIISGLQKVYEIGKVFRNEGIDSTHNAEFSTLEFYETYMSMDDIVTRTEDLFKFLITNLQKFFQDTRLPVPKTFSELHLALSENNWKFRKVEFLPTLNKELGIDLMNSGLDINKPSELLKALPKDIAKKYFPSADNTGQLSSLQILNKLSDVFLEQRHCQSTLPTVIYHQPAILSPLAKTDPQNKQVTKRFEVFIKGKEYINAYEEENCPQLQLQKFLQQKQINELTGNKTETLSPVIDYQYVETMKYGMPPVGGFGLGIDRLCMLFCDKKRIEEVLPFGCVDDVNRQ"},{"created_at":"2011-05-26T19:05:24.000Z","updated_at":"2011-05-27T15:01:05.000Z","name":"Lysyl-tRNA synthetase, cytoplasmic","uniprot_id":"P15180","uniprot_name":"SYKC_YEAST","enzyme":true,"transporter":false,"gene_name":"KRS1","num_residues":591,"molecular_weight":"67958.0","theoretical_pi":"6.01","general_function":"Involved in nucleotide binding","specific_function":"ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)","reactions":[{"id":1719,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2561,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"J04186","genbank_protein_id":"171799","gene_card_id":"KRS1","chromosome_location":"chromosome 4","locus":"YDR037W","synonyms":["Lysine--tRNA ligase","LysRS"],"enzyme_classes":["6.1.1.6"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" lysine-tRNA ligase activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ligase activity"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" lysyl-tRNA aminoacylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic 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transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"MFS_1","identifier":"PF07690"}],"pathways":[],"gene_sequence":"ATGCAAACACTAGACGAGACTTCAAATCTACTCCCTCCACCTGAGGAAGCTGAAGCCCCTCCCTTGGAACAAAAATTTCATGAATATAATTTGGCCTTACCTAAGTTTCCCATTTTGTTTTCGCTATGGTTGGGTAGTTTTTTGAGTTCCTTGGATAGCACTATTGTCGCAAATATAATGAATAGAGTTGCTGAGGAATTCTCTGAATCAAGTAAAAAGCAATGGATTGCGACGAGTTTTCTTTTGACAAATACGGCTTTCCAACCACTATATGGGAAGCTTTCTGATATAACAGGGCGGAAGTCAGCATTATTAACCGCTCAATTTTTTTTTGGCCTTGGGTGCTTATTAACATGTTTTGCCAGAAACGTCACGGAATTCTCAATAGCAAGAGCCATATGTGGTATTGGTGCAGGAGGATTGAATGCTATTAGTAGCATTGCTGTTAGTGACATATGTACAGCAAGAGAAAGGGGCGTTTACCAGGGATATGCGAATATTGTTTTCGGGTTTGGTCAATTACTAGGTGCTCCGTTGGGTGGTGTATTTATAGAAACCATTGGATGGAGGGCTCTTTTTGGTATCCAAGTACCCGTGATAATGTTGTGCTCGGTATTAGCAATCAAAAACATTAATATTAAGCTATTCCATGTTCCTCCTATGAAAGAAAGATATACCTTAAAGAATCTGTCACGGATAGATATATTTGGCTCATTAAGCCTGGTGGCGACCATTAGTGGAGTTTTATTTTTGTGCTCTAGCCAGTTGAACAAGTTGTATTTAGCATTGTTTACCATTGGTAGCTTTATTGTTTTTATCCTGGTTGAACGTTATTACGCGACTGAGAAAATTTTACCATTCGAACTATTGACTCGCTCATTCTGTTTGAGCTCAGCGGTAACGGTTATATCTTCATTTGTTGTATTTGGTGAAATCTTTAGGTCACCAATCTATTTACAATTGCTTCAAAATATTAGTGTAACAAAGACTGGCCTCTTTTTGATTTTCCCCTCTATATCAGTTGCAGTCGGATCATTGGTAACAGGATGGGTATTGCGGAATACGAAAATTAACCTAGCACACTGTGCATATCAAATCATTTTTGGTGGTATGATAATGCAGCTATTGGGTTTGGGATTGGGCTATTTCCTACTTTCACACTTGAATCCTGACTACACCATATATGATATGCTTGAGTCTATTACATTCAGATCTAACTCAATATGGTGGAAATTGATATATGTGTTTGCATCAGTCCTTGTGTCCTTTGGTTACGCTTGTCTATTAGTGGCCACGTTAGTAAGCATCGTATTCACCGTCGAAAAATCACAGCAAGGAACCATGACTGGTGTTTTCTATTTGTGGAGATCCATTGGTAACGTTCTTGGTGCCTCTTTAACTTTAGTGTCCTATGAGAATAGCCTGTCGTCCATGTTATGGAATTATATGTTCAAAACCAAGCGTGATGACGAATATCACTTCACCAAAAAGCAGTACTACTCCCTTATCAATGATTCGAGTTACTTGAGAGGGCCCAATTTTCCAACGGATATATTTGTTCGCATTCTTGATGTCTACAAAAAGGCATTCCTGATTTCCTATATTCCAAATATAGCCCTGGCAGCAGTGGGAATTGTTTTATCGTTATATCTGGTGAAACATACTTACAAACGTAGTTCAAGTTCTTGA","protein_sequence":"MQTLDETSNLLPPPEEAEAPPLEQKFHEYNLALPKFPILFSLWLGSFLSSLDSTIVANIMNRVAEEFSESSKKQWIATSFLLTNTAFQPLYGKLSDITGRKSALLTAQFFFGLGCLLTCFARNVTEFSIARAICGIGAGGLNAISSIAVSDICTARERGVYQGYANIVFGFGQLLGAPLGGVFIETIGWRALFGIQVPVIMLCSVLAIKNINIKLFHVPPMKERYTLKNLSRIDIFGSLSLVATISGVLFLCSSQLNKLYLALFTIGSFIVFILVERYYATEKILPFELLTRSFCLSSAVTVISSFVVFGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAVGSLVTGWVLRNTKINLAHCAYQIIFGGMIMQLLGLGLGYFLLSHLNPDYTIYDMLESITFRSNSIWWKLIYVFASVLVSFGYACLLVATLVSIVFTVEKSQQGTMTGVFYLWRSIGNVLGASLTLVSYENSLSSMLWNYMFKTKRDDEYHFTKKQYYSLINDSSYLRGPNFPTDIFVRILDVYKKAFLISYIPNIALAAVGIVLSLYLVKHTYKRSSSS"},{"created_at":"2011-05-27T06:51:35.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Vacuolar 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membrane"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" transmembrane transport"}],"pfams":[{"name":"Sugar_tr","identifier":"PF00083"},{"name":"MFS_1","identifier":"PF07690"}],"pathways":[],"gene_sequence":"ATGAATATGCTCATTGTCGGTAGAGTTGTTGCTAGTGTTGGGGGAAGCGGACTTCAAACGCTTTGCTTTGTTATTGGTTGTACGATGGTTGGTGAAAGGTCACGTCCATTGGTGATTTCCATCCTAAGTTGTGCATTTGCTGTAGCTGCTATCGTTGGTCCTATAATCGGAGGTGCCTTTACAACCCATGTTACCTGGAGGTGGTGCTTCTATATCAATCTTCCTATCGGTGGTCTTGCCATTATTATGTTTTTACTCACATATAAGGCCGAGAATAAGGGTATACTTCAACAAATTAAAGATGCTATAGGAACAATCTCGAGCTTTACTTTTAGTAAGTTCAGACACCAAGTTAATTTTAAAAGACTTATGAATGGCATAATCTTCAAGTTTGACTTCTTTGGTTTTGCCCTCTGCTCTGCAGGGCTGGTCCTTTTCCTACTGGGGCTAACCTTTGGTGGTAATAAATATAGTTGGAACTCTGGCCAAGTCATCGCATATTTGGTTTTGGGTGTCTTACTTTTTATTTTTTCATTGGTGTACGATTTCTTCTTATTCGATAAATTCAACCCGGAACCTGATAATATATCCTACAGGCCTCTCCTTCTAAGAAGATTGGTAGCAAAACCAGCCATAATAATAATAAACATGGTAACATTTCTATTATGTACCGGTTACAATGGGCAAATGATATACTCTGTCCAGTTTTTCCAACTTATATTTGCGTCGAGTGCATGGAAAGCCGGTCTTCACTTGATACCAATCGTTATTACCAACGTTATTGCGGCCATTGCAAGTGGTGTGATTACCAAAAAGCTCGGTTTAGTTAAACCACTCTTAATATTTGGAGGCGTTCTTGGGGTAATTGGAGCAGGGCTTATGACACTTATGACAAATACGTCCACGAAGTCAACTCAAATTGGTGTTTTGCTATTACCGGGGTTTTCCCTTGGATTTGCTCTACAAGCATCGCTCATGAGTGCACAGCTTCAAATTACCAAAGATCGTCCAGAAGCTGCTATGGACTTTATTGAAGTAACAGCTTTCAATACATTCATGAAGTCATTAGGTACAACTCTTGGTGGTGTGCTTTCAACCACTGTTTTTTCCGCCTCCTTTCACAACAAAGTATCACGAGCTCATCTAGAGCCTTACGAAGGAAAAACGGTTGATGACATGATTTTGTATCGTCTTCAAAACTACGACGGTTCTCATTCGACTATTGGAAACATTTTAAGCGACTCCATTAAGAACGTATTTTGGATGGATCTAGGGTTTTATGCCTTAGGATTTTTGTTTTGTAGTTTTTCATCCAATAAGAAATTAATCATACCAAAAAAGGACGAGACACCAGAAGATAATTTAGAAGACAAGTAG","protein_sequence":"MNMLIVGRVVASVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLAIIMFLLTYKAENKGILQQIKDAIGTISSFTFSKFRHQVNFKRLMNGIIFKFDFFGFALCSAGLVLFLLGLTFGGNKYSWNSGQVIAYLVLGVLLFIFSLVYDFFLFDKFNPEPDNISYRPLLLRRLVAKPAIIIINMVTFLLCTGYNGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLVKPLLIFGGVLGVIGAGLMTLMTNTSTKSTQIGVLLLPGFSLGFALQASLMSAQLQITKDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTVFSASFHNKVSRAHLEPYEGKTVDDMILYRLQNYDGSHSTIGNILSDSIKNVFWMDLGFYALGFLFCSFSSNKKLIIPKKDETPEDNLEDK"},{"created_at":"2011-05-27T06:52:17.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Vacuolar basic amino acid transporter 2","uniprot_id":"P38358","uniprot_name":"VBA2_YEAST","enzyme":false,"transporter":true,"gene_name":"VBA2","num_residues":474,"molecular_weight":"51676.39844","theoretical_pi":"10.15","general_function":"Involved in transmembrane transport","specific_function":"Transporter required for vacuolar uptake of histidine, arginine and lysine and to a lesser extent tyrosine","reactions":[],"signal_regions":"None","transmembrane_regions":"34-54;63-85;98-118;122-142;168-188;197-217;239-259;274-294;304-324;332-352;376-396;448-468","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"AY692630","genbank_protein_id":"51012711","gene_card_id":"VBA2","chromosome_location":"chromosome 2","locus":"YBR293W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"MFS_1","identifier":"PF07690"}],"pathways":[],"gene_sequence":"ATGAGTATTTCAAATTGGATCACCACTGCGTATTTAATTACATCAACATCTTTTCAACCTCTTTATGGGTCATTTTCTGATGCACTTGGTCGAAGAAACTGCCTTTTCTTTGCTAATGGGGCTTTTACCATTGGATGTCTAGCCTGTGGTTTCTCGAAAAACATCTACATGCTTAGTTTTATGAGAGCATTGACAGGCATAGGAGGTGGTGGCTTGATCACACTTTCTACAATCGTAAATTCAGACGTTATTCCAAGTTCGAAAAGAGGAATTTTTCAAGCGTTTCAGAATTTACTTTTGGGATTTGGTGCCATATGTGGAGCGTCTTTCGGTGGCACAATAGCGTCGAGCATTGGTTGGAGGTGGTGTTTTCTCATCCAAGTACCCATATCTGTGATTAGTTCCATATTAATGAATTATTATGTACCTAATCAGAAAGAATATAATCGTCAAAATTCTAGCATATTCCAAAATCCCGGAAAAATACTCAGGGACATAGATGTTATGGGCTCAATTCTTATTATAACTGGTCTCACACTACAGCTTCTTTACCTGAGCCTGGGGTGTTCTACTTCTAAATTATCATGGACCAGCCCTTCTGTGCTACTGCTATTAGTTGGGAGTGTAATAATCCTCTTACTGTTCATATTGCACGAAAGGAAAACAAGTGCTAGAGCGATTATTCCTATGGAGCTGGTCAATTCCTCCTACAGTGTCGTTGTACTTTCGATAAGTATACTTGTTGGTTTTGCCAGCTACGCGTATCTTTTTACTTTACCATTATTCTTTCAGATTGTACTTGGAGATTCCACTGCAAAAGCAGGATTACGTCTTACGATTCCTTCCCTATTTACTCCGGTAGGCAGTCTCATAACAGGATTTTCCATGAGCAAGTACAACTGTCTAAGATTATTACTCTACATTGGTATTTCTTTGATGTTTTTGGGTAACTTTTTATTCCTGTTTATTGAAAAAACTTCTCCGAACTGGTTGATTGGTCTATTTTTGATACCTGCAAATCTAGGACAAGGTATCACTTTTCCTACGACCTTGTTTACTTTCATATTTATGTTCTCTAAGAGTGACCAAGCTACTGCGACATCAACTTTATATTTATTCCGTAGTATTGGATCTGTATGGGGTGTTGCAATTTCAGCTGGCGTCATTCAATTATCTTTCGCAGGTTTATTGCGTAGTAATTTGAAAGGTCTACTGGATGAAAACAAGATAAAGAAACTTATTGTTCAGCTTAGTGCAAACTCCTCATATATTGGATCTTTACATGGCGAAGTTAAAAACACAGTCATAAAGAGTTTTGATGAGGCAACAAAGAGGGCTCATCTAATGTCTACATTACTCTCTTCATTGGCCCTGATACTCTGCATCCTTAAAGACAATCTGGCGAAACCTAAAACAAGAAGATAA","protein_sequence":"MSISNWITTAYLITSTSFQPLYGSFSDALGRRNCLFFANGAFTIGCLACGFSKNIYMLSFMRALTGIGGGGLITLSTIVNSDVIPSSKRGIFQAFQNLLLGFGAICGASFGGTIASSIGWRWCFLIQVPISVISSILMNYYVPNQKEYNRQNSSIFQNPGKILRDIDVMGSILIITGLTLQLLYLSLGCSTSKLSWTSPSVLLLLVGSVIILLLFILHERKTSARAIIPMELVNSSYSVVVLSISILVGFASYAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPVGSLITGFSMSKYNCLRLLLYIGISLMFLGNFLFLFIEKTSPNWLIGLFLIPANLGQGITFPTTLFTFIFMFSKSDQATATSTLYLFRSIGSVWGVAISAGVIQLSFAGLLRSNLKGLLDENKIKKLIVQLSANSSYIGSLHGEVKNTVIKSFDEATKRAHLMSTLLSSLALILCILKDNLAKPKTRR"},{"created_at":"2011-05-27T06:52:56.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Lysine-specific permease","uniprot_id":"P32487","uniprot_name":"LYP1_YEAST","enzyme":false,"transporter":true,"gene_name":"LYP1","num_residues":611,"molecular_weight":"68089.10156","theoretical_pi":"6.99","general_function":"Involved in transport","specific_function":"High-affinity permease for lysine","reactions":[],"signal_regions":"None","transmembrane_regions":"116-136;142-162;186-205;224-243;257-274;304-321;345-365;399-418;446-464;474-494;514-532;548-566","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"X67315","genbank_protein_id":"297445","gene_card_id":"LYP1","chromosome_location":"chromosome 14","locus":"YNL268W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGGCAGGTTTAGTAACATAATAACGTCCAATAAATGGGACGAGAAACAAAACAACATTGGCGAACAGAGCATGCAGGAATTACCAGAAGACCAGATAGAACATGAGATGGAAGCAATAGATCCAAGTAATAAGACGACCCCATACTCTATTGATGAGAAACAGTACAACACAAAAAAGAAGCATGGGTCATTGCAAGGTGGCGCAATCGCTGATGTAAATTCGATAACTAATTCGTTAACAAGATTGCAAGTTGTCTCTCATGAACCAGATATTGACGAGGATGAAGAAGAAGCCCACTATGAGGATAAACACGTGAAGAGAGCCTTGAAGCAAAGACACATTGGTATGATTGCACTAGGTGGTACAATCGGTACTGGTCTTTTCGTTGGTATCTCCACTCCCTTGAGTAATGCTGGCCCTGTGGGGTCCCTGATTGCTTACATTTTCATGGGCACCATTGTCTACTTCGTTACCCAGTCACTTGGTGAGATGGCTACGTTTATCCCCGTGACATCATCTATCACTGTCTTTTCGAAGAGGTTCTTATCACCTGCATTCGGTGTTTCTAACGGTTACATGTACTGGTTCAATTGGGCTATTACTTATGCTGTGGAGGTTTCTGTCATTGGCCAAGTTATTGAATACTGGACAGATAAAGTTCCATTAGCGGCCTGGATTGCGATATTCTGGGTAATTATTACTTTGATGAATTTTTTCCCTGTCAAAGTTTATGGTGAATTTGAGTTCTGGGTGGCCTCTGTTAAAGTTTTAGCCATTATGGGTTACTTGATATATGCTTTGATTATTGTCTGTGGTGGATCCCACCAGGGCCCTATCGGTTTCAGGTACTGGAGAAATCCAGGAGCCTGGGGGCCAGGCATCATCTCCAGTGATAAAAGTGAAGGCCGTTTTCTCGGATGGGTCTCCTCCTTGATTAATGCTGCATTTACGTACCAAGGTACTGAACTGGTTGGGATCACCGCTGGTGAAGCGGCTAACCCAAGAAAGACCGTTCCAAGAGCTATCAATAAAGTCGTCTTTAGAATCGTACTATTCTATATTATGTCTTTGTTCTTTATTGGTCTACTGGTTCCATACAACGATTCCCGTTTATCTGCTAGTTCTGCTGTTATTGCATCATCACCCTTCGTTATTTCCATTCAAAACGCTGGTACTTATGCTCTTCCAGATATTTTCAACGCCGTGGTGTTGATTACTGTTGTATCTGCCGCTAATTCGAATGTTTACGTTGGTTCCCGTGTTCTTTACTCTTTAGCTAGGACTGGTAACGCACCAAAGCAATTTGGATACGTCACCAGACAGGGTGTTCCATATCTCGGTGTTGTTTGCACTGCTGCATTGGGTCTTTTGGCATTCCTGGTTGTCAATAACAATGCAAACACTGCATTTAACTGGTTGATCAACATTTCCACTTTGGCTGGGTTATGCGCCTGGTTATTCATCTCTTTGGCACATATTAGGTTCATGCAAGCTTTAAAGCACCGTGGTATTTCTCGTGATGATCTGCCCTTCAAGGCCAAATTGATGCCTTATGGTGCCTACTACGCAGCCTTTTTTGTCACCGTCATCATATTCATCCAAGGGTTCCAAGCGTTCTGTCCGTTCAAAGTTTCTGAGTTTTTCACATCTTACATCTCCTTGATTCTTTTAGCCGTTATGTTCATCGGTTGCCAGATATACTACAAATGCAGATTTATTTGGAAGCTAGAAGATATTGACATCGATTCCGACAGAAGAGAAATCGAAGCAATTATCTGGGAAGACGACGAGCCTAAGAATTTATGGGAGAAATTCTGGGCTGCTGTTGCATAA","protein_sequence":"MGRFSNIITSNKWDEKQNNIGEQSMQELPEDQIEHEMEAIDPSNKTTPYSIDEKQYNTKKKHGSLQGGAIADVNSITNSLTRLQVVSHETDINEDEEEAHYEDKHVKRALKQRHIGMIALGGTIGTGLFVGISTPLSNAGPVGSLIAYIFMGTIVYFVTQSLGEMATFIPVTSSITVFSKRFLSPAFGVSNGYMYWFNWAITYAVEVSVIGQVIEYWTDKVPLAAWIAIFWVIITLMNFFPVKVYGEFEFWVASVKVLAIMGYLIYALIIVCGGSHQGPIGFRYWRNPGAWGPGIISSDKSEGRFLGWVSSLINAAFTYQGTELVGITAGEAANPRKTVPRAINKVVFRIVLFYIMSLFFIGLLVPYNDSRLSASSAVIASSPFVISIQNAGTYALPDIFNAVVLITVVSAANSNVYVGSRVLYSLARTGNAPKQFGYVTRQGVPYLGVVCTAALGLLAFLVVNNNANTAFNWLINISTLAGLCAWLFISLAHIRFMQALKHRGISRDDLPFKAKLMPYGAYYAAFFVTVIIFIQGFQAFCPFKVSEFFTSYISLILLAVVFIGCQIYYKCRFIWKLEDIDIDSDRREIEAIIWEDDEPKNLWEKFWAAVA"}]}