{"ymdb_id":"YMDB00325","created_at":"2011-05-29T18:06:22.000Z","updated_at":"2016-09-08T18:35:21.000Z","name":"2-trans,6-trans-farnesyl diphosphate","cas":"13058-04-3","state":"Solid","melting_point":null,"description":"Farnesyl pyrophosphate (FPP) is an intermediate in the HMG-CoA reductase pathway used by organisms in the biosynthesis of terpenes, terpenoids, and sterols. It is the immediate precursor of squalene (via the enzyme squalene synthase), dehydrodolichol diphosphate (a precursor of dolichol), and geranylgeranyl pyrophosphate (GGPP). [Wikipedia]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion;cytoplasm","synthesis_reference":null,"chebi_id":"17407","hmdb_id":"HMDB00961","kegg_id":"C00448","pubchem_id":"445713","cs_id":"23092868","foodb_id":null,"wikipedia_link":"Farnesyl pyrophosphate","biocyc_id":"FARNESYL-PP","iupac":"{[hydroxy({[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy})phosphoryl]oxy}phosphonic acid","traditional_iupac":"farnesyl diphosphate","logp":"3.6167330606666663","pka":"3.2043406094078315","alogps_solubility":"8.07e-02 g/l","alogps_logp":"2.40","alogps_logs":"-3.68","acceptor_count":"5","donor_count":"3","rotatable_bond_count":"11","polar_surface_area":"113.28999999999999","refractivity":"96.73049999999999","polarizability":"37.94192720134606","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":null,"pka_strongest_acidic":"1.7672186885241006","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2E,6E)-farnesol diphosphate","(2E,6E)-Farnesyl diphosphate","(2E,6E)-Farnesyl pyrophosphate","(all-E)-Farnesyl diphosphate","(E,E)-Farnesyl diphosphate","(E,E)-Farnesyl pyrophosphate","2-trans,6-trans-Farnesyl diphosphate","2-trans,6-trans-Farnesyl pyrophosphate","all-trans-farnesyl diphosphate","all-trans-Farnesyl pyrophosphate","Farnesyl diphosphate","Farnesyl pyrophosphate","Farnesyl pyrophosphic acid","Farnesyl-PP","FPP","fpp, farnesyl pyrophosphate","omega,E,E-farnesyl diphosphate","trans-Farnesyl pyrophosphate","trans-trans-Farnesyl diphosphate","trans-trans-Farnesyl pyrophosphate","trans, trans-farnesyl diphosphate","trans,trans-farnesyl diphosphate"],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"},{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Porphyrin Metabolism","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-26T18:23:18.000Z","updated_at":"2011-07-22T17:54:38.000Z","name":"Farnesyl pyrophosphate synthase","uniprot_id":"P08524","uniprot_name":"FPPS_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG20","num_residues":352,"molecular_weight":"40483.0","theoretical_pi":"5.11","general_function":"Involved in isoprenoid biosynthetic process","specific_function":"Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate","reactions":[{"id":1466,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1562,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2529,"direction":"\u003e","locations":"Cytoplasm","altext":"Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2530,"direction":"\u003e","locations":"Cytoplasm","altext":"Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14374,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006891","source":"Smpdb"},{"id":14375,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006892","source":"Smpdb"},{"id":14376,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007264","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"J05091","genbank_protein_id":"171517","gene_card_id":"ERG20","chromosome_location":"chromosome 10","locus":"YJL167W","synonyms":["FPP synthase","FPS","Farnesyl diphosphate synthase","Dimethylallyltranstransferase","Geranyltranstransferase"],"enzyme_classes":["2.5.1.10","2.5.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" isoprenoid metabolic process"},{"category":"Process","description":" isoprenoid biosynthetic process"}],"pfams":[{"name":"polyprenyl_synt","identifier":"PF00348"}],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGGCTTCAGAAAAAGAAATTAGGAGAGAGAGATTCTTGAACGTTTTCCCTAAATTAGTAGAGGAATTGAACGCATCGCTTTTGGCTTACGGTATGCCTAAGGAAGCATGTGACTGGTATGCCCACTCATTGAACTACAACACTCCAGGCGGTAAGCTAAATAGAGGTTTGTCCGTTGTGGACACGTATGCTATTCTCTCCAACAAGACCGTTGAACAATTGGGGCAAGAAGAATACGAAAAGGTTGCCATTCTAGGTTGGTGCATTGAGTTGTTGCAGGCTTACTTCTTGGTCGCCGATGATATGATGGACAAGTCCATTACCAGAAGAGGCCAACCATGTTGGTACAAGGTTCCTGAAGTTGGGGAAATTGCCATCAATGACGCATTCATGTTAGAGGCTGCTATCTACAAGCTTTTGAAATCTCACTTCAGAAACGAAAAATACTACATAGATATCACCGAATTGTTCCATGAGGTCACCTTCCAAACCGAATTGGGCCAATTGATGGACTTAATCACTGCACCTGAAGACAAAGTCGACTTGAGTAAGTTCTCCCTAAAGAAGCACTCCTTCATAGTTACTTTCAAGACTGCTTACTATTCTTTCTACTTGCCTGTCGCATTGGCCATGTACGTTGCCGGTATCACGGATGAAAAGGATTTGAAACAAGCCAGAGATGTCTTGATTCCATTGGGTGAATACTTCCAAATTCAAGATGACTACTTAGACTGCTTCGGTACCCCAGAACAGATCGGTAAGATCGGTACAGATATCCAAGATAACAAATGTTCTTGGGTAATCAACAAGGCATTGGAACTTGCTTCCGCAGAACAAAGAAAGACTTTAGACGAAAATTACGGTAAGAAGGACTCAGTCGCAGAAGCCAAATGCAAAAAGATTTTCAATGACTTGAAAATTGAACAGCTATACCACGAATATGAAGAGTCTATTGCCAAGGATTTGAAGGCCAAAATTTCTCAGGTCGATGAGTCTCGTGGCTTCAAAGCTGATGTCTTAACTGCGTTCTTGAACAAAGTTTACAAGAGAAGCAAATAG","protein_sequence":"MASEKEIRRERFLNVFPKLVEELNASLLAYGMPKEACDWYAHSLNYNTPGGKLNRGLSVVDTYAILSNKTVEQLGQEEYEKVAILGWCIELLQAYFLVADDMMDKSITRRGQPCWYKVPEVGEIAINDAFMLEAAIYKLLKSHFRNEKYYIDITELFHEVTFQTELGQLMDLITAPEDKVDLSKFSLKKHSFIVTFKTAYYSFYLPVALAMYVAGITDEKDLKQARDVLIPLGEYFQIQDDYLDCFGTPEQIGKIGTDIQDNKCSWVINKALELASAEQRKTLDENYGKKDSVAEAKCKKIFNDLKIEQLYHEYEESIAKDLKAKISQVDESRGFKADVLTAFLNKVYKRSK"},{"created_at":"2011-05-26T18:23:57.000Z","updated_at":"2011-07-22T17:54:42.000Z","name":"Geranylgeranyl pyrophosphate synthase","uniprot_id":"Q12051","uniprot_name":"GGPPS_YEAST","enzyme":true,"transporter":false,"gene_name":"BTS1","num_residues":335,"molecular_weight":"38651.0","theoretical_pi":"6.04","general_function":"Involved in isoprenoid biosynthetic process","specific_function":"Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting","reactions":[{"id":1484,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2529,"direction":"\u003e","locations":"Cytoplasm","altext":"Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2530,"direction":"\u003e","locations":"Cytoplasm","altext":"Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2531,"direction":"\u003e","locations":"Cytoplasm","altext":"Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692852","genbank_protein_id":"51013155","gene_card_id":"BTS1","chromosome_location":"chromosome 16","locus":"YPL069C","synonyms":["GGPP synthase","GGPPSase","BET2 suppressor protein 1","Geranylgeranyl diphosphate synthase","Dimethylallyltranstransferase","Geranyltranstransferase","Farnesyltranstransferase"],"enzyme_classes":["2.5.1.1","2.5.1.29","2.5.1.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" isoprenoid metabolic process"},{"category":"Process","description":" isoprenoid biosynthetic process"}],"pfams":[{"name":"polyprenyl_synt","identifier":"PF00348"}],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"}],"gene_sequence":"ATGGAGGCCAAGATAGATGAGCTGATCAATAATGATCCTGTTTGGTCCAGCCAAAATGAAAGCTTGATTTCAAAACCTTATAATCACATCCTTTTGAAACCTGGCAAGAACTTTAGACTAAATTTAATAGTTCAAATTAACAGAGTTATGAATTTGCCCAAAGACCAGCTGGCCATAGTTTCGCAAATTGTTGAGCTCTTGCATAATTCCAGCCTTTTAATCGACGATATAGAAGATAATGCTCCCTTGAGAAGGGGACAGACCACTTCTCACTTAATCTTCGGTGTACCCTCCACTATAAACACCGCAAATTATATGTATTTCAGAGCCATGCAACTTGTATCGCAGCTAACCACAAAAGAGCCTTTGTATCATAATTTGATTACGATTTTCAACGAAGAATTGATCAATCTACATAGGGGACAAGGCTTGGATATATACTGGAGAGACTTTCTGCCTGAAATCATACCTACTCAGGAGATGTATTTGAATATGGTTATGAATAAAACAGGCGGCCTTTTCAGATTAACGTTGAGACTCATGGAAGCGCTGTCTCCTTCCTCACACCACGGCCATTCGTTGGTTCCTTTCATAAATCTTCTGGGTATTATTTATCAGATTAGAGATGATTACTTGAATTTGAAAGATTTCCAAATGTCCAGCGAAAAAGGCTTTGCTGAGGACATTACAGAGGGGAAGTTATCTTTTCCCATCGTCCACGCCCTTAACTTCACTAAAACGAAAGGTCAAACTGAGCAACACAATGAAATTCTAAGAATTCTCCTGTTGAGGACAAGTGATAAAGATATAAAACTAAAGCTGATTCAAATACTGGAATTCGACACCAATTCATTGGCCTACACCAAAAATTTTATTAATCAATTAGTGAATATGATAAAAAATGATAATGAAAATAAGTATTTACCTGATTTGGCTTCGCATTCCGACACCGCCACCAATTTACATGACGAATTGTTATATATAATAGACCACTTATCCGAATTGTGA","protein_sequence":"MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLPDLASHSDTATNLHDELLYIIDHLSEL"},{"created_at":"2011-05-27T04:20:38.000Z","updated_at":"2011-05-27T15:01:22.000Z","name":"Squalene synthase","uniprot_id":"P29704","uniprot_name":"FDFT_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG9","num_residues":444,"molecular_weight":"51719.39844","theoretical_pi":"5.75","general_function":"Involved in transferase activity","specific_function":"May regulate the flux of isoprene intermediates through the sterol pathway. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. ERG9 is also essential for cell growth in yeast","reactions":[{"id":1980,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2762,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"2 farnesyl diphosphate = diphosphate + presqualene diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2763,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Presqualene diphosphate + NAD(P)H = squalene + diphosphate + NAD(P)(+).","export":false,"pw_reaction_id":null,"source":null},{"id":14378,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006893","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"291-311;421-441","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"M63979","genbank_protein_id":"171481","gene_card_id":"ERG9","chromosome_location":"chromosome 8","locus":"YHR190W","synonyms":["SQS","SS","FPP:FPP farnesyltransferase","Farnesyl-diphosphate farnesyltransferase"],"enzyme_classes":["2.5.1.21"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" prenyltransferase activity"},{"category":"Function","description":" farnesyltranstransferase activity"},{"category":"Function","description":" farnesyl-diphosphate farnesyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" lipid biosynthetic process"}],"pfams":[{"name":"SQS_PSY","identifier":"PF00494"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGGGAAAGCTATTACAATTGGCATTGCATCCGGTCGAGATGAAGGCAGCTTTGAAGCTGAAGTTTTGCAGAACACCGCTATTCTCCATCTATGATCAGTCCACGTCTCCATATCTCTTGCACTGTTTCGAACTGTTGAACTTGACCTCCAGATCGTTTGCTGCTGTGATCAGAGAGCTGCATCCAGAATTGAGAAACTGTGTTACTCTCTTTTATTTGATTTTAAGGGCTTTGGATACCATCGAAGACGATATGTCCATCGAACACGATTTGAAAATTGACTTGTTGCGTCACTTCCACGAGAAATTGTTGTTAACTAAATGGAGTTTCGACGGAAATGCCCCCGATGTGAAGGACAGAGCCGTTTTGACAGATTTCGAATCGATTCTTATTGAATTCCACAAATTGAAACCAGAATATCAAGAAGTCATCAAGGAGATCACCGAGAAAATGGGTAATGGTATGGCCGACTACATCTTGGATGAAAATTACAACTTGAATGGGTTGCAAACCGTCCACGACTACGACGTGTACTGTCACTACGTAGCTGGTTTGGTCGGTGATGGTTTGACCCGTTTGATTGTCATTGCCAAGTTTGCCAACGAATCTTTGTATTCTAATGAGCAATTGTATGAAAGCATGGGTCTTTTCCTACAAAAAACCAACATCATCAGAGACTACAATGAAGATTTGGTCGATGGTAGATCCTTCTGGCCCAAGGAAATCTGGTCACAATACGCTCCTCAGTTGAAGGACTTCATGAAACCTGAAAACGAACAACTGGGGTTGGACTGTATAAACCACCTCGTCTTAAACGCATTGAGTCATGTTATCGATGTGTTGACTTATTTGGCCAGTATCCACGAGCAATCCACTTTCCAATTTTGTGCCATTCCCCAAGTTATGGCCATTGCAACCTTGGCTTTGGTATTCAACAACCGTGAAGTGCTACATGGCAATGTAAAGATTCGTAAGGGTACTACCTGCTATTTAATTTTGAAATCAAGGACTTTGCGTGGCTGTGTCGAGATTTTTGACTATTACTTACGTGATATCAAATCTAAATTGGCTGTGCAAGATCCAAATTTCTTAAAATTGAACATTCAAATCTCCAAGATCGAACAATTCATGGAAGAAATGTACCAGGATAAATTACCTCCTAACGTGAAGCCAAATGAAACTCCAATTTTCTTGAAAGTTAAAGAAAGATCCAGATACGATGATGAATTGGTCCCAACCCAACAAGAAGAAGAGTACAAGTTCAATATGGTTTTATCTATCATCTTGTCCGTTCTTCTTGGGTTTTATTATATATACACTTTACACAGAGCGTGA","protein_sequence":"MGKLLQLALHPVEMKAALKLKFCRTPLFSIYDQSTSPYLLHCFELLNLTSRSFAAVIRELHPELRNCVTLFYLILRALDTIEDDMSIEHDLKIDLLRHFHEKLLLTKWSFDGNAPDVKDRAVLTDFESILIEFHKLKPEYQEVIKEITEKMGNGMADYILDENYNLNGLQTVHDYDVYCHYVAGLVGDGLTRLIVIAKFANESLYSNEQLYESMGLFLQKTNIIRDYNEDLVDGRSFWPKEIWSQYAPQLKDFMKPENEQLGLDCINHLVLNALSHVIDVLTYLAGIHEQSTFQFCAIPQVMAIATLALVFNNREVLHGNVKIRKGTTCYLILKSRTLRGCVEIFDYYLRDIKSKLAVQDPNFLKLNIQISKIEQFMEEMYQDKLPPNVKPNETPIFLKVKERSRYDDELVPTQQEEEYKFNMVLSIILSVLLGFYYIYTLHRA"},{"created_at":"2011-05-27T05:10:06.000Z","updated_at":"2011-05-29T05:06:41.000Z","name":"Protoheme IX farnesyltransferase, mitochondrial","uniprot_id":"P21592","uniprot_name":"COX10_YEAST","enzyme":true,"transporter":false,"gene_name":"COX10","num_residues":462,"molecular_weight":"52147.19922","theoretical_pi":"10.33","general_function":"Involved in protoheme IX farnesyltransferase activity","specific_function":"Converts protoheme IX and farnesyl diphosphate to heme O","reactions":[{"id":1625,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"141-165;180-198;221-239;250-268;338-356;369-386;429-453","pdb_id":null,"cellular_location":"Mitochondrion membrane; Multi-pass membrane protein","genbank_gene_id":"M55566","genbank_protein_id":"171265","gene_card_id":"COX10","chromosome_location":"chromosome 16","locus":"YPL172C","synonyms":["Heme O synthase"],"enzyme_classes":["2.5.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" mitochondrial membrane"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" organelle membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" farnesyltranstransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" protoheme IX farnesyltransferase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" prenyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" heme O biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" heme biosynthetic process"},{"category":"Process","description":" tetrapyrrole metabolic process"},{"category":"Process","description":" porphyrin metabolic process"},{"category":"Process","description":" porphyrin biosynthetic process"}],"pfams":[{"name":"UbiA","identifier":"PF01040"}],"pathways":[],"gene_sequence":"ATGAGTTACTTTCCTCGAACATATGCTCACTTGATGAGAAATGTTCTTGCTCATAATAAAGGGAATATATACTTACAAATTGGTACACAGCTGCACGATACTCAAATAAAAATTCGATTTAATGGAGTTCGTTATATTAGTCGGAATCATGGCGGGAAACAGCAACATATAAACACTGCGCCGATAGAATTTACTCCCAATTTTGGATATGGTGATAGAACCTCTAATTGCAATAAAAAGGTTGAATCGACTGCCATGAAAACGCTAAGATGCACAGATGATATATCAACTTCAAGTGGAAGCGAAGCTACTACCGATGCAAGCACACAACTTCCATTTAATGTCAAACTTGTAGACCCGATGGTAAGAAAATCTAAGAGACCATCTCACGCAATCAGCGAAGGGCTGAATATGAAAACTTTAAAGAAGAAGGTAATTATGCCATATCTTCAGTTGACCAAGCCCCGACTCACCATTCTAGTGATGTTAAGTGCCATTTGTTCGTATGCTTTATCTCCATATCCAGCCTCCGTCAATGAATTGTTATGTTTAACAGTAGGCACTACTTTGTGTTCCGGTTCTGCAAACGCTATAAATATGGGCAGAGAGCCAGAATTTGATAGACAAATGGTGAGAACTCAGGCGAGGCCCGTTGTTAGAGGTGATGTTACACCTACCCAGGCATTCGAGTTTGCCGCACTTATCGGAACATTAGGAGTATCTATCTTGTACTTTGGTGTTAATCCTACCGTTGCTATTCTTGGTGCTTCAAATATCGCGTTATATGGCTGGGCCTATACGTCTATGAAAAGAAAGCATATCATTAACACATGGTTAGGTGCCCTAGTAGGAATGGTACCTCCTCTAATGGGATGGGCAGCCGCAAGTCCGCTTTCACATCCGGGATCTTGGTGCCTTGCTGGTCTATTGTTTGCTTGGCAATTCCCACACTTTAATACGTTGAGTCATAACATTAGAAATGAATACAAAAATGCCGGATACGTTATGACTGCATGGAAAAATCCGCTCCTAAACGCCCGTGTGTCGTTGAGATACTCTATCCTAATGTTCCCTTTATGTTTCGGATTGTCTTATTTTAATATCACAGATTGGTACTACCAAATAGATTCCGGACTTATAAATGCCTGGCTAACGTTCTGGGCTTTCAAATTCTATTGGCAACAAAGAATCAACTATTCTGCAAAAACATTAAAAGATAACGTCAAGTTTAATAAAGGTCTAAGTGTAGCCAACATTTATGCAAGGAAAACTTTTATGGCTAGTGTATTGCACCTACCGGCAATTCTAATCCTAGCCATTATACATAAAAAAGGCCGCTGGGATTGGATATATCCTGGTGAAGCAAAGCGACCACAGGAACGATTTTAG","protein_sequence":"MSYFPRTYAHLMRNVLAHNKGNIYLQIGTQLHDTQIKIRFNGVRYISRNHGGKQQHINTAPIEFTPNFGYGDRTSNCNKKVESTAMKTLRCTDDISTSSGSEATTDASTQLPFNVKLVDPMVRKSKRPSHAISEGLNMKTLKKKVIMPYLQLTKPRLTILVMLSAICSYALSPYPASVNELLCLTVGTTLCSGSANAINMGREPEFDRQMVRTQARPVVRGDVTPTQAFEFAALIGTLGVSILYFGVNPTVAILGASNIALYGWAYTSMKRKHIINTWLGALVGMVPPLMGWAAASPLSHPGSWCLAGLLFAWQFPHFNTLSHNIRNEYKNAGYVMTAWKNPLLNARVSLRYSILMFPLCFGLSYFNITDWYYQIDSGLINAWLTFWAFKFYWQQRINYSAKTLKDNVKFNKGLSVANIYARKTFMASVLHLPAILILAIIHKKGRWDWIYPGEAKRPQERF"}]}