{"ymdb_id":"YMDB00324","created_at":"2011-05-29T18:06:16.000Z","updated_at":"2016-09-08T18:35:20.000Z","name":"Prephenate","cas":"126-49-8","state":"Solid","melting_point":"","description":"Prephenate is an intermediate in the biosynthesis of the aromatic amino acids phenylalanine and tyrosine.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":null,"chebi_id":"16666","hmdb_id":"HMDB12283","kegg_id":"C00254","pubchem_id":"1028","cs_id":"1001","foodb_id":null,"wikipedia_link":"Prephenic_acid","biocyc_id":"PREPHENATE","iupac":"1-(2-carboxy-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid","traditional_iupac":"prephenic acid","logp":"0.06097045266666673","pka":"3.87542455823727","alogps_solubility":"3.60e+01 g/l","alogps_logp":"-0.31","alogps_logs":"-0.80","acceptor_count":"6","donor_count":"3","rotatable_bond_count":"4","polar_surface_area":"111.9","refractivity":"53.55400000000001","polarizability":"19.72902046696766","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-2.1244212194274477","pka_strongest_acidic":"2.891510507673818","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["1-Carboxy-4-hydroxy-2,5-cyclohexadiene-1-pyruvic acid","PRE","Prephenate","Prephenic acid"],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":2697638,"citation":"Mannhaupt, G., Stucka, R., Pilz, U., Schwarzlose, C., Feldmann, H. (1989). \"Characterization of the prephenate dehydrogenase-encoding gene, TYR1, from Saccharomyces cerevisiae.\" Gene 85:303-311."},{"pubmed_id":3027508,"citation":"Ball, S. G., Wickner, R. B., Cottarel, G., Schaus, M., Tirtiaux, C. (1986). \"Molecular cloning and characterization of ARO7-OSM2, a single yeast gene necessary for chorismate mutase activity and growth in hypertonic medium.\" Mol Gen Genet 205:326-330."}],"proteins":[{"created_at":"2011-05-26T18:07:16.000Z","updated_at":"2011-07-22T17:54:27.000Z","name":"Cholinephosphotransferase 1","uniprot_id":"P17898","uniprot_name":"CPT1_YEAST","enzyme":true,"transporter":false,"gene_name":"CPT1","num_residues":393,"molecular_weight":"44829.0","theoretical_pi":"6.57","general_function":"Involved in phosphotransferase activity, for other substituted phosphate groups","specific_function":"Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. The multiple transmembrane domains and lumenal hydrophilic domains of the cholinephosphotransferase might participate in the transport process","reactions":[{"id":1386,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1387,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2507,"direction":"\u003e","locations":"Microsome membrane; Multi-pass membrane protein; Multi-pass membrane protein. Endoplasmic reticulum membrane","altext":"CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.","export":false,"pw_reaction_id":null,"source":null},{"id":14462,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006981","source":"Smpdb"},{"id":14463,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006984","source":"Smpdb"},{"id":14464,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007002","source":"Smpdb"},{"id":14465,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047264","source":"Smpdb"},{"id":14466,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047316","source":"Smpdb"},{"id":14467,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047322","source":"Smpdb"},{"id":14468,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047327","source":"Smpdb"},{"id":14469,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047333","source":"Smpdb"},{"id":14470,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047339","source":"Smpdb"},{"id":14471,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047344","source":"Smpdb"},{"id":14472,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047350","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"41-61;173-193;211-231;264-284;286-306;321-341;349-369","pdb_id":null,"cellular_location":"Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"J05203","genbank_protein_id":"171318","gene_card_id":"CPT1","chromosome_location":"chromosome 14","locus":"YNL130C","synonyms":["Diacylglycerol cholinephosphotransferase 1","Sn-1,2-diacylglycerol cholinephosphotransferase","CHOPT"],"enzyme_classes":["2.7.8.2"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" phosphotransferase activity, for other substituted phosphate groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" phospholipid biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"CDP-OH_P_transf","identifier":"PF01066"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Ether lipid metabolism","kegg_map_id":"00565"},{"name":"Choline metabolism","kegg_map_id":null},{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER 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dehydrogenase [NADP+]","uniprot_id":"P20049","uniprot_name":"TYR1_YEAST","enzyme":true,"transporter":false,"gene_name":"TYR1","num_residues":452,"molecular_weight":"50922.89844","theoretical_pi":"6.57","general_function":"Involved in oxidoreductase activity","specific_function":"Prephenate + NADP(+) = 4-hydroxyphenylpyruvate + CO(2) + NADPH","reactions":[{"id":1910,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2683,"direction":"\u003e","locations":null,"altext":"Prephenate + NADP(+) = 4-hydroxyphenylpyruvate + CO(2) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":14102,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006522","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z36035","genbank_protein_id":"536506","gene_card_id":"TYR1","chromosome_location":"chromosome 2","locus":"YBR166C","synonyms":["PRDH"],"enzyme_classes":["1.3.1.13","1.3.1.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" prephenate dehydrogenase (NADP+) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" aromatic amino acid family metabolic process"},{"category":"Process","description":" tyrosine metabolic process"},{"category":"Process","description":" tyrosine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"PDH","identifier":"PF02153"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"}],"gene_sequence":"ATGGTATCAGAGGATAAGATTGAGCAATGGAAAGCCACAAAAGTCATTGGTATAATTGGTCTGGGTGATATGGGCCTATTATACGCTAATAAATTTACAGATGCTGGATGGGGTGTTATATGTTGTGATAGGGAAGAATATTATGATGAACTGAAAGAAAAATATGCCTCAGCTAAATTCGAACTGGTGAAAAATGGTCATTTGGTATCCAGGCAAAGCGACTATATTATCTATAGTGTTGAAGCATCCAATATTAGTAAGATCGTCGCAACGTATGGACCATCTTCTAAGGTTGGAACAATTGTTGGGGGTCAAACGAGTTGTAAGCTGCCGGAAATCGAGGCTTTCGAAAAGTATTTACCCAAGGACTGCGACATCATTACCGTGCATTCCCTTCATGGGCCTAAAGTTAATACTGAAGGCCAACCACTAGTTATTATCAATCACAGATCACAGTACCCAGAATCTTTTGAGTTCGTTAATTCTGTTATGGCATGTTTGAAAAGTAAGCAAGTTTATTTGACATATGAAGAGCATGACAAGATTACCGCTGATACACAAGCTGTGACACATGCTGCTTTCTTAAGTATGGGATCTGCGTGGGCAAAGATAAAGATTTATCCTTGGACTCTGGGTGTAAACAAATGGTACGGTGGCCTAGAAAATGTGAAAGTTAATATATCACTAAGAATCTATTCGAACAAGTGGCATGTTTACGCAGGATTAGCCATAACAAACCCAAGTGCACATCAGCAAATTCTTCAATATGCAACCAGTGCAACAGAACTATTTAGTTTAATGATAGATAACAAAGAACAAGAACTTACTGATAGACTATTAAAAGCTAAGCAATTTGTATTTGGAAAGCATACTGGTCTCTTACTATTGGATGACACGATTTTAGAGAAATATTCGCTATCAAAAAGCAGCATTGGTAACAGCAACAATTGCAAGCCAGTGCCGAATTCACATTTATCATTGTTGGCGATTGTTGATTCGTGGTTTCAACTTGGTATTGATCCATATGATCATATGATTTGTTCGACGCCATTATTCAGAATATTCCTGGGTGTGTCCGAATATCTTTTTTTAAAACCTGGCTTATTAGAACAGACAATTGATGCAGCTATCCATGATAAATCATTCATAAAAGATGATTTAGAATTTGTTATTTCGGCTAGAGAATGGAGCTCGGTTGTTTCTTTTGCCAATTTTGATATATACAAAAAGCAATTTCAGAGTGTTCAAAAGTTCTTTGAGCCAATGCTTCCAGAGGCTAATCTCATTGGCAACGAGATGATAAAAACCATTCTGAGTCATTCTAGTGACCGTTCGGCCGCTGAAAAAAGAAATACATAA","protein_sequence":"MVSEDKIEQWKATKVIGIIGLGDMGLLYANKFTDAGWGVICCDREEYYDELKEKYASAKFELVKNGHLVSRQSDYIIYSVEASNISKIVATYGPSSKVGTIVGGQTSCKLPEIEAFEKYLPKDCDIITVHSLHGPKVNTEGQPLVIINHRSQYPESFEFVNSVMACLKSKQVYLTYEEHDKITADTQAVTHAAFLSMGSAWAKIKIYPWTLGVNKWYGGLENVKVNISLRIYSNKWHVYAGLAITNPSAHQQILQYATSATELFSLMIDNKEQELTDRLLKAKQFVFGKHTGLLLLDDTILEKYSLSKSSIGNSNNCKPVPNSHLSLLAIVDSWFQLGIDPYDHMICSTPLFRIFLGVSEYLFLKPGLLEQTIDAAIHDKSFIKDDLEFVISAREWSSVVSFANFDIYKKQFQSVQKFFEPMLPEANLIGNEMIKTILSHSSDRSAAEKRNT"},{"created_at":"2011-05-27T02:44:03.000Z","updated_at":"2011-07-22T17:54:27.000Z","name":"Chorismate mutase","uniprot_id":"P32178","uniprot_name":"CHMU_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO7","num_residues":256,"molecular_weight":"29746.80078","theoretical_pi":"6.17","general_function":"Involved in chorismate mutase activity","specific_function":"Chorismate = prephenate","reactions":[{"id":1388,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2691,"direction":"\u003e","locations":null,"altext":"Chorismate = prephenate.","export":false,"pw_reaction_id":null,"source":null},{"id":14091,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006516","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"4CSM","cellular_location":null,"genbank_gene_id":"AY693179","genbank_protein_id":"51013809","gene_card_id":"ARO7","chromosome_location":"chromosome 16","locus":"YPR060C","synonyms":["CM"],"enzyme_classes":["5.4.99.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Function","description":" chorismate mutase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" aromatic amino acid family biosynthetic process"},{"category":"Process","description":" dicarboxylic acid metabolic process"},{"category":"Process","description":" chorismate metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"CM_2","identifier":"PF01817"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"}],"gene_sequence":"ATGGATTTCACAAAACCAGAAACTGTTTTAAATCTACAAAATATTAGAGATGAATTAGTTAGAATGGAGGATTCGATCATCTTCAAATTTATTGAGAGGTCGCATTTCGCCACATGTCCTTCAGTTTATGAGGCAAACCATCCAGGTTTAGAAATTCCGAATTTTAAAGGATCTTTCTTGGATTGGGCTCTTTCAAATCTTGAAATTGCGCATTCTCGCATCAGAAGATTCGAATCACCTGATGAAACTCCCTTCTTTCCTGACAAGATTCAGAAATCATTCTTACCGAGCATTAACTACCCACAAATTTTGGCGCCTTATGCCCCAGAAGTTAATTACAATGATAAAATAAAAAAAGTTTATATTGAAAAGATTATACCATTAATTTCGAAAAGAGATGGTGATGATAAGAATAACTTCGGTTCTGTTGCCACTAGAGATATAGAATGTTTGCAAAGCTTGAGTAGGAGAATCCACTTTGGCAAGTTTGTTGCTGAAGCCAAGTTCCAATCGGATATCCCGCTATACACAAAGCTGATCAAAAGTAAAGATGTCGAGGGGATAATGAAGAATATCACCAATTCTGCCGTTGAAGAAAAGATTCTAGAAAGATTAACTAAGAAGGCTGAAGTCTATGGTGTGGACCCTACCAACGAGTCAGGTGAAAGAAGGATTACTCCAGAATATTTGGTAAAAATTTATAAGGAAATTGTTATACCTATCACTAAGGAAGTTGAGGTGGAATACTTGCTAAGAAGGTTGGAAGAGTAA","protein_sequence":"MDFTKPETVLNLQNIRDELVRMEDSIIFKFIERSHFATCPSVYEANHPGLEIPNFKGSFLDWALSNLEIAHSRIRRFESPDETPFFPDKIQKSFLPSINYPQILAPYAPEVNYNDKIKKVYIEKIIPLISKRDGDDKNNFGSVATRDIECLQSLSRRIHFGKFVAEAKFQSDIPLYTKLIKSKDVEGIMKNITNSAVEEKILERLTKKAEVYGVDPTNESGERRITPEYLVKIYKEIVIPITKEVEVEYLLRRLEE"},{"created_at":"2011-05-29T04:13:42.000Z","updated_at":"2011-05-29T05:06:53.000Z","name":"Putative prephenate dehydratase","uniprot_id":"P32452","uniprot_name":"PHA2_YEAST","enzyme":true,"transporter":false,"gene_name":"PHA2","num_residues":334,"molecular_weight":"38224.80078","theoretical_pi":"6.13","general_function":"Involved in prephenate dehydratase activity","specific_function":"Prephenate = phenylpyruvate + H(2)O + CO(2)","reactions":[{"id":1908,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2842,"direction":"\u003e","locations":"Cytoplasm","altext":"Prephenate = phenylpyruvate + H(2)O + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":14092,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006517","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"PHA2","chromosome_location":"chromosome 14","locus":"YNL316C","synonyms":["PDT","Phenylalanine-requiring protein 2"],"enzyme_classes":["4.2.1.51"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" hydro-lyase activity"},{"category":"Function","description":" prephenate dehydratase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aromatic amino acid family metabolic process"},{"category":"Process","description":" L-phenylalanine metabolic process"},{"category":"Process","description":" L-phenylalanine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"}],"pfams":[{"name":"PDT","identifier":"PF00800"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"}],"gene_sequence":"ATGGCCAGCAAGACTTTGAGGGTTCTTTTTCTGGGTCCCAAAGGTACGTATTCCCATCAAGCTGCATTACAACAATTTCAATCAACATCTGATGTTGAGTACCTCCCAGCAGCCTCTATCCCCCAATGTTTTAACCAATTGGAGAACGACACTAGTATAGATTATTCAGTGGTACCGTTGGAAAATTCCACCAATGGACAAGTAGTTTTTTCCTATGATCTCTTGCGTGATAGGATGATCAAAAAAGCCCTATCCTTACCTGCTCCAGCAGATACTAATAGAATTACACCAGATATAGAAGTTATAGCGGAGCAATATGTACCCATTACCCATTGTCTAATCAGCCCAATCCAACTACCAAATGGTATTGCATCCCTTGGAAATTTTGAAGAAGTCATAATACACTCACATCCGCAAGTATGGGGCCAGGTTGAATGTTACTTAAGGTCCATGGCAGAAAAATTTCCGCAGGTCACCTTTATAAGATTGGATTGTTCTTCCACATCTGAATCAGTGAACCAATGCATTCGGTCATCAACGGCCGATTGCGACAACATTCTGCATTTAGCCATTGCTAGTGAAACAGCTGCCCAATTGCATAAGGCGTACATCATTGAACATTCGATAAATGATAAGCTAGGAAATACAACAAGATTTTTAGTATTGAAGAGAAGGGAGAACGCAGGCGACAATGAAGTAGAAGACACTGGATTACTACGGGTTAACCTACTCACCTTTACTACTCGTCAAGATGACCCTGGTTCTTTGGTAGATGTTTTGAACATACTAAAAATCCATTCACTCAACATGTGTTCTATAAACTCTAGACCATTCCATTTGGACGAACATGATAGAAACTGGCGATATTTATTTTTCATTGAATATTACACCGAGAAGAATACCCCAAAGAATAAAGAAAAATTCTATGAAGATATCAGCGACAAAAGTAAACAGTGGTGCCTGTGGGGTACATTCCCCAGAAATGAGAGATATTATCACAAATAA","protein_sequence":"MASKTLRVLFLGPKGTYSHQAALQQFQSTSDVEYLPAASIPQCFNQLENDTSIDYSVVPLENSTNGQVVFSYDLLRDRMIKKALSLPAPADTNRITPDIEVIAEQYVPITHCLISPIQLPNGIASLGNFEEVIIHSHPQVWGQVECYLRSMAEKFPQVTFIRLDCSSTSESVNQCIRSSTADCDNILHLAIASETAAQLHKAYIIEHSINDKLGNTTRFLVLKRRENAGDNEVEDTGLLRVNLLTFTTRQDDPGSLVDVLNILKIHSLNMCSINSRPFHLDEHDRNWRYLFFIEYYTEKNTPKNKEKFYEDISDKSKQWCLWGTFPRNERYYHK"}]}