{"ymdb_id":"YMDB00304","created_at":"2011-05-29T18:04:12.000Z","updated_at":"2016-10-18T17:11:26.000Z","name":"L-Phenylalanine","cas":"63-91-2","state":"Solid","melting_point":"283 oC","description":"Phenylalanine (abbreviated as Phe or F) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a nonpolar, aromatic amino acid, because of the hydrophobic nature of the benzyl side chain. L-Phenylalanine (LPA) is an electrically neutral amino acid. It is used in the manufacture of food and drink products and sold as a nutritional supplement for its reputed analgesic and antidepressant effects. Biosynthesis of phenylalanine, tyrosine, and tryptophan proceeds via a common pathway to chorismate, at which point the pathway branches.  One branch proceeds to phenylalanine and tyrosine, and the other to tryptophan. The phenylalanine and tyrosine branch has one reaction in common, rearrangement of chorismate to prephenate, at which point, the pathway branches again to either phenylalanine or tyrosine.  S. cerevisiae, similar to E. coli, synthesizes phenylalanine and tyrosine via the intermediate 4-hydroxyphenylpyruvate and phenylpyruvate, respectively. Aromatic amino acid biosynthesis in S. cerevisiae is controlled by a combination of feedback inhibition, activation of enzyme activity, and regulation of enzyme synthesis.  The carbon flow through the pathways is regulated primarily at the initial step and the branching points by the terminal end-products. The initial step of chorismate biosynthesis can be catalyzed by two isoenzymes Aro3p or Aro4p, whereby Aro3p is inhibited by phenylalanine, and Aro4p by tyrosine. The first step in the phenylalanine-tyrosine branch is feedback inhibited by tyrosine and activated by tryptophan.  Phenylalanine normally has only three metabolic fates: incorporation into polypeptide chains, production of tyrosine via the tetrahydrobiopterin-requiring phenylalanine hydroxylase and conversion to a fusel alcohol. S. cerevisiae degrade the aromatic amino acids (tryptophan, phenylalanine, and tyrosine) and the branched-chain amino acids (valine, leucine, and iso-leucine) via the Ehrlich pathway.  This pathway consists of 3 steps: 1) deamination of the amino acid to the corresponding alpha-keto acid; 2) decarboxylation of the resulting alpha-keto acid to the respective aldehyde; and, 3) reduction of the aldehyde to form the corresponding long chain or complex alcohol, known as a fusel alcohol or fusel oil. Fusel alcohols are important flavor and aroma compounds in yeast-fermented food products and beverages.","experimental_water_solubility":"26.9 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-1.38 [AVDEEF,A (1997)]","location":"extracellular;mitochondrion;cytoplasm","synthesis_reference":"Zhou, Hua; Zhong, Yao; Sun, Guanghai; Wei, Ping.  Preparation of L-phenylalanine by an aqueous two-phase system.  Huaxue Fanying Gongcheng Yu Gongyi  (2006),  22(2),  146-150.","chebi_id":"17295","hmdb_id":"HMDB00159","kegg_id":"C00079","pubchem_id":"6140","cs_id":"5910","foodb_id":null,"wikipedia_link":"Phenylalanine","biocyc_id":"PHE","iupac":"(2S)-2-amino-3-phenylpropanoic acid","traditional_iupac":"L-phenylalanine","logp":"-1.184438468740489","pka":null,"alogps_solubility":"4.14e+00 g/l","alogps_logp":"-1.35","alogps_logs":"-1.60","acceptor_count":"3","donor_count":"2","rotatable_bond_count":"3","polar_surface_area":"63.31999999999999","refractivity":"45.11630000000001","polarizability":"17.0319763846329","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.446936344396194","pka_strongest_acidic":"2.469229772182635","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(-)-beta-Phenylalanine","(L)-Phenylalanine","(S)-(-)-Phenylalanine","(S)-2-amino-3-phenylpropanoate","(S)-2-amino-3-phenylpropanoic acid","(S)-2-Amino-3-phenylpropionate","(S)-2-Amino-3-phenylpropionic acid","(S)-alpha-Amino-benzenepropanoate","(S)-alpha-Amino-benzenepropanoic acid","(S)-alpha-Amino-beta-phenylpropionate","(S)-alpha-Amino-beta-phenylpropionic acid","(S)-alpha-Aminobenzenepropanoate","(S)-alpha-Aminobenzenepropanoic acid","(S)-alpha-Aminohydrocinnamate","(S)-alpha-Aminohydrocinnamic acid","(S)-Phenylalanine","3-Phenyl-L-alanine","alpha-Aminohydrocinnamate","alpha-Aminohydrocinnamic acid","beta-Phenyl-alpha-alanine","beta-Phenyl-L-alanine","beta-Phenylalanine","L-2-Amino-3-phenylpropionate","L-2-Amino-3-phenylpropionic acid","Phe","phenyl-Alanine","Phenylalamine","Phenylalanine"],"pathways":[{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"growth_conditions":[{"growth_media":"YPD media","concentration":"1427.98974","concentration_units":"\u0026#181;M","error":"28.55385"},{"growth_media":"YPG media","concentration":"1179.63077","concentration_units":"\u0026#181;M","error":"23.49744"},{"growth_media":"SD media","concentration":"310.52308","concentration_units":"\u0026#181;M","error":"6.24615"},{"growth_media":"SG media","concentration":"186.19487","concentration_units":"\u0026#181;M","error":"3.86667"},{"growth_media":"M (molasses)","concentration":"682.91282","concentration_units":"\u0026#181;M","error":"13.68205"},{"growth_media":"MA (molasses)","concentration":"2794.11282","concentration_units":"\u0026#181;M","error":"55.91795"},{"growth_media":"MB (molasses)","concentration":"993.4359","concentration_units":"\u0026#181;M","error":"19.92821"},{"growth_media":"MAB (molasses)","concentration":"3042.47179","concentration_units":"\u0026#181;M","error":"60.97436"},{"growth_media":"YEB media with 0.5 mM glucose","concentration":"1415.0","concentration_units":"\u0026#181;M","error":"71.0"},{"growth_media":"Synthetic medium with 20 g/L glucose","concentration":"540.0","concentration_units":"\u0026#181;M","error":"64.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"1.6","concentration_units":"umol/g DW","error":"0.0"}],"references":[{"pubmed_id":7654310,"citation":"Martinez-Force, E., Benitez, T. (1995). \"Effects of varying media, temperature, and growth rates on the intracellular concentrations of yeast amino acids.\" Biotechnol Prog 11:386-392."},{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":12902239,"citation":"Vuralhan, Z., Morais, M. A., Tai, S. L., Piper, M. D., Pronk, J. T. (2003). \"Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae.\" Appl Environ Microbiol 69:4534-4541."},{"pubmed_id":10935926,"citation":"Vaseghi, S., Baumeister, A., Rizzi, M., Reuss, M. (1999). \"In vivo dynamics of the pentose phosphate pathway in Saccharomyces cerevisiae.\" Metab Eng 1:128-140."},{"pubmed_id":12584756,"citation":"Hans, M. A., Heinzle, E., Wittmann, C. (2003). \"Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.\" Biotechnol Bioeng 82:143-151."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."},{"pubmed_id":9491083,"citation":"Iraqui, I., Vissers, S., Cartiaux, M., Urrestarazu, A. (1998). \"Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily.\" Mol Gen Genet 257:238-248."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T20:11:48.000Z","updated_at":"2011-05-27T14:56:00.000Z","name":"Tryptophan permease","uniprot_id":"P38967","uniprot_name":"TAT2_YEAST","enzyme":false,"transporter":true,"gene_name":"TAT2","num_residues":592,"molecular_weight":"65403.80078","theoretical_pi":"8.42","general_function":"Involved in transport","specific_function":"Required for high-affinity tryptophan transport. Also transports cysteine, phenyalanine and tyrosine","reactions":[],"signal_regions":"None","transmembrane_regions":"88-108;114-134;161-181;193-213;227-247;267-287;307-327;359-379;405-425;429-449;473-493;515-535","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"D16304","genbank_protein_id":"1113091","gene_card_id":"TAT2","chromosome_location":"chromosome 15","locus":"YOL020W","synonyms":["Tryptophan amino acid transporter"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGACCGAAGACTTTATTTCTTCTGTCAAGCGTTCAAATGAGGAGCTGAAGGAGCGAAAATCTAACTTTGGATTTGTAGAATACAAATCCAAGCAATTAACATCATCCTCATCACACAATTCAAACTCATCGCATCACGATGATGACAACCAACACGGCAAGAGGAATATTTTCCAGCGATGTGTTGATTCTTTCAAGTCTCCTCTGGACGGCTCGTTCGACACAAGTAATTTGAAGAGGACTCTGAAACCAAGGCACTTAATCATGATTGCCATTGGGGGCAGTATAGGTACTGGTTTGTTTGTCGGTAGTGGTAAGGCAATCGCCGAAGGTGGTCCTCTTGGTGTCGTCATTGGTTGGGCTATTGCAGGCTCTCAAATCATCGGGACGATTCATGGGCTAGGTGAAATCACGGTGCGGTTCCCCGTTGTCGGGGCCTTTGCCAATTACGGCACAAGGTTTTTGGATCCAAGTATAAGTTTTGTTGTTTCGACCATATACGTGCTACAGTGGTTTTTTGTATTACCCTTAGAAATCATTGCGGCGGCAATGACCGTAACGTACTGGAACTCGTCTATTGACCCCGTAATTTGGGTAGCCATCTTTTATGCTGTTATTGTTTCCATAAATTTGTTTGGTGTACGAGGTTTTGGGGAAGCGGAATTTGCATTTTCCACCATAAAAGCAATAACAGTTTGCGGATTCATTATATTGTGCGTTGTCCTCATTTGCGGTGGAGGTCCCGACCACGAGTTCATTGGCGCCAAATACTGGCACGACCCTGGTTGTTTGGCCAATGGGTTCCCGGGCGTTCTATCTGTTCTTGTTGTTGCTTCGTATTCTCTCGGTGGTATAGAAATGACGTGCCTGGCATCAGGTGAAACGGACCCCAAAGGCTTACCAAGTGCTATCAAGCAAGTGTTTTGGAGGATCTTATTTTTCTTTTTGATATCACTGACCCTGGTAGGATTCCTGGTTCCATATACAAACCAAAACTTACTGGGTGGTTCATCTGTGGACAACTCACCTTTTGTCATTGCCATAAAATTGCATCACATTAAAGCCTTGCCCTCCATCGTCAATGCGGTCATCCTTATCAGTGTTTTGAGTGTAGGTAACTCCTGCATCTTCGCTTCAAGTAGAACGTTGTGTTCGATGGCCCACCAAGGCCTTATTCCATGGTGGTTTGGTTATATCGACCGTGCTGGTAGGCCGCTGGTTGGCATTATGGCAAATTCACTATTTGGATTACTAGCATTTCTGGTCAAATCTGGCTCGATGTCTGAAGTTTTCAATTGGTTAATGGCCATTGCCGGCCTGGCCACGTGCATTGTCTGGTTGAGCATCAACCTGTCACATATCAGATTTAGACTGGCGATGAAGGCTCAAGGGAAGTCTCTGGATGAATTAGAATTTGTTAGTGCTGTCGGGATTTGGGGATCAGCGTATTCCGCTTTAATCAACTGTCTAATCTTGATAGCTCAATTCTATTGTTCACTATGGCCCATTGGTGGCTGGACCAGCGGCAAAGAAAGGGCTAAAATATTTTTTCAAAATTATCTGTGTGCCTTAATCATGTTATTTATATTCATCGTCCACAAAATTTATTACAAGTGTCAAACAGGCAAATGGTGGGGGGTTAAGGCGTTAAAGGACATAGATTTGGAAACCGATCGTAAAGATATCGACATCGAAATAGTCAAGCAAGAAATTGCCGAAAAGAAAATGTACCTAGATTCCCGTCCATGGTACGTGAGACAGTTCCATTTCTGGTGTTAA","protein_sequence":"MTEDFISSVKRSNEELKERKSNFGFVEYKSKQLTSSSSHNSNSSHHDDDNQHGKRNIFQRCVDSFKSPLDGSFDTSNLKRTLKPRHLIMIAIGGSIGTGLFVGSGKAIAEGGPLGVVIGWAIAGSQIIGTIHGLGEITVRFPVVGAFANYGTRFLDPSISFVVSTIYVLQWFFVLPLEIIAAAMTVQYWNSSIDPVIWVAIFYAVIVSINLFGVRGFGEAEFAFSTIKAITVCGFIILCVVLICGGGPDHEFIGAKYWHDPGCLANGFPGVLSVLVVASYSLGGIEMTCLASGETDPKGLPSAIKQVFWRILFFFLISLTLVGFLVPYTNQNLLGGSSVDNSPFVIAIKLHHIKALPSIVNAVILISVLSVGNSCIFASSRTLCSMAHQGLIPWWFGYIDRAGRPLVGIMANSLFGLLAFLVKSGSMSEVFNWLMAIAGLATCIVWLSINLSHIRFRLAMKAQGKSLDELEFVSAVGIWGSAYSALINCLILIAQFYCSLWPIGGWTSGKERAKIFFQNYLCALIMLFIFIVHKIYYKCQTGKWWGVKALKDIDLETDRKDIDIEIVKQEIAEKKMYLDSRPWYVRQFHFWC"},{"created_at":"2011-05-24T21:03:21.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Leu/Val/Ile amino-acid permease","uniprot_id":"P38084","uniprot_name":"BAP2_YEAST","enzyme":false,"transporter":true,"gene_name":"BAP2","num_residues":609,"molecular_weight":"67669.60156","theoretical_pi":"8.22","general_function":"Involved in transport","specific_function":"Permease for leucine, valine and isoleucine. Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan","reactions":[],"signal_regions":"None","transmembrane_regions":"100-120;124-144;174-194;211-231;236-256;290-310;329-349;375-395;428-448;452-472;501-521;537-557","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z35937","genbank_protein_id":"536316","gene_card_id":"BAP2","chromosome_location":"chromosome 2","locus":"YBR068C","synonyms":["Branched-chain amino-acid permease 2"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGCTATCTTCAGAAGATTTTGGATCTTCTGGGAAAAAGGAAACTTCTCCTGATTCGATATCGATACGTTCCTTTAGTGCCGGGAATAATTTCCAATCATCATCAAGTGAGAAAACTTATTCTAAGCAAAAATCCGGGAGTGACAAACTTATACATAGATTTGCGGATTCATTCAAAAGAGCCGAGGGTAGCACTACAAGAACTAAGCAAATAAATGAAAATACGTCTGATTTAGAGGATGGCGTTGAGTCTATCACGTCGGATTCCAAGTTGAAAAAGTCCATGAAGTCGCGCCATGTTGTCATGATGTCTTTAGGGACAGGTATTGGGACTGGTCTTTTGGTAGCTAATGCAAAAGGTCTACATTACGGTGGTCCTGCTGCGCTAATAATTGGTTACATCTTGGTTTCTTTCGAGACGTACTTCATGATCCAAGCTGCAGGTGAGATGGCGGTAACCTATCCGACTTTACCAGCAAATTTCAACGCATACTCCTCCATATTCATTTCCAAATCATTTGGATTCGCCACAGTATGGCTTTACTGTTTCCAATGGCTAACGGTTTTGCCTTTAGAGTTAATAACCGCGTCTATGACTATTCAATTTGGGAATGATAAAATAAATCCGGACATTTATATTCTTATTTTCTATGTTTTCTTAGTATTCATTCATTTCTTCGGTGTAAAAGCCTATGGTGAAACGGAATTCATCTTCAATTGCTGTAAAATTTTAATGATTGCAGGTTTCATTATTCTTTCTATTGTTATCAACTGTGGTGGGGCCGGAAATGACGGTTATATCGGGGCCACTTATTGGCATAATCCAGGTGCTTTTGCAGGTGACACATCGATTGGTAGGTTCAAAAACGTTTGCTATATTTTAGTTACTGCTTACTTCTCCTTTGGTGGTATGGAATTATTTGCACTAAGTGTTCAGGAACAGTCTAACCCTAGAAAATCTACTCCGGTGGCAGCCAAGAGAAGCATTTATCGTATCGTTGTGATTTATCTTTTGACTATGATCCTCATTGGATTCAATGTTCCATATAATGATGACCAACTAATGGGCGCAGGCGGATCCGCTACACATGCATCTCCCTATGTCTTAGCCGCTTCTATTCACGGTGTGAAAATTGTTCCACATATTATCAACGCTGTTATTTTGATTTCTGTGGTTTCAGTGGCAAATTCCTCTTTGTATGCTGGTCCAAGACTGATTTGCTCTTTGGCCCAACAAGGCTACGCACCCAAGTTTTTAGATTACGTTGACAGAGAGGGCAGGCCCTTGAGAGCTCTTATTGTGTGTTGCGTTTTCGGCGTCATTGCTTTTGTTGCAGCTTCATCAAAGGAAGAGATCGTGTTTACATGGTTAGCAGCTATCGCAGGCTTGAGTGAATTATTCACATGGACTTCCATAATGTTGTCCCATCTGCGATTCAGACAAGCAATGAAAGTACAGGGAAGGTCTCTAGACGAGTTGGGATACAAGGCCACAACAGGGATTTGGGGTTCCATATACGGTGTCTTTTTTAATATTTTAGTCTTTGTTGCCCAATTTTGGGTAGCATTGGCCCCCTTAGGTAATGGGGGCAAATGCGATGCGGAATCCTTCTTTCAAAATTATTTAGCTTTTCCAATATGGTTGGCCTTTTACTTCGGATATATGGTTTACAACCGAGATTTTACGCTATTAAATCCCCTCGACAAGATTGACCTTGACTTCCACAGACGCATTTATGATCCAGAGCTAATGAGACAAGAGGACGAAGAAAATAAAGAAAAACTAAGGAATATGTCTTTGATGAGAAAAGCTTATCATTTCTGGTGTTAA","protein_sequence":"MLSSEDFGSSGKKETSPDSISIRSFSAGNNFQSSSSEKTYSKQKSGSDKLIHRFADSFKRAEGSTTRTKQINENTSDLEDGVESITSDSKLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLHYGGPAALIIGYILVSFETYFMIQAAGEMAVTYPTLPANFNAYSSIFISKSFGFATVWLYCFQWLTVLPLELITASMTIQFGNDKINPDIYILIFYVFLVFIHFFGVKAYGETEFIFNCCKILMIAGFIILSIVINCGGAGNDGYIGATYWHNPGAFAGDTSIGRFKNVCYILVTAYFSFGGMELFALSVQEQSNPRKSTPVAAKRSIYRIVVIYLLTMILIGFNVPYNDDQLMGAGGSATHASPYVLAASIHGVKIVPHIINAVILISVVSVANSSLYAGPRLICSLAQQGYAPKFLDYVDREGRPLRALIVCCVFGVIAFVAASSKEEIVFTWLAAIAGLSELFTWTSIMLSHLRFRQAMKVQGRSLDELGYKATTGIWGSIYGVFFNILVFVAQFWVALAPLGNGGKCDAESFFQNYLAFPIWLAFYFGYMVYNRDFTLLNPLDKIDLDFHRRIYDPELMRQEDEENKEKLRNMSLMRKAYHFWC"},{"created_at":"2011-05-24T21:05:56.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Valine amino-acid permease","uniprot_id":"P41815","uniprot_name":"BAP3_YEAST","enzyme":false,"transporter":true,"gene_name":"BAP3","num_residues":604,"molecular_weight":"67364.39844","theoretical_pi":"8.28","general_function":"Involved in transport","specific_function":"Involved in transport of isoleucine, leucine, valine, cysteine, methionine, phenylalanine, tyrosine and tryptophan","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;120-140;170-190;207-227;239-259;285-305;324-344;378-398;424-444;450-470;503-523;532-552","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z49209","genbank_protein_id":"798899","gene_card_id":"BAP3","chromosome_location":"chromosome 4","locus":"YDR046C","synonyms":["Branched-chain amino-acid permease 3"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCAGATCCTATAGTAACGTCTTCCAAAATGGAAAAAAGTGCAGAGTTTGAAGTAACAGACTCTGCTTTATATAATAACTTCAATACATCAACAACAGCTTCACTAACTCCGGAGATTAAGGAACATTCTGAGGAATCTCGCAATGGGTTAGTTCACAGATTCGTCGACTCATTCAGAAGAGCCGAAAGCCAACGTTTAGAAGAAGACAATGACTTGGAGGATGGTACCAAATCGATGAAATCTAATAACCACTTAAAAAAGTCAATGAAATCTAGACATGTTGTAATGATGTCTTTAGGTACAGGGATAGGAACAGGTCTTCTAGTTGCCAACGCCAAAGGTTTGAGTCTTGCAGGCCCGGGGTCTTTAGTCATCGGTTACGTTATGGTGTCCTTCGTCACGTATTTTATGGTCCAAGCGGCTGGTGAGATGGGTGTCACTTATCCGACGCTTCCAGGTAACTTCAATGCATACAATTCAATCTTTATTTCAAAGTCGTTTGGGTTCGCGACCACTTGGTTATTTTGCATTCAGTGGTTAACTGTGCTACCGTTGGAATTGATTACTTCTTCCATGACCGTCAAGTACTGGAATGACACAATTAATGCTGATGTATTCATTGTCATTTTCTATGTGTTTTTATTGTTTATCCACTTTTTTGGTGTTAAGGCATACGGTGAAACGGAATTTATCTTCAATTCCTGTAAGATATTGATGGTTGCAGGATTCATTATTTTATCAGTCGTCATCAATTGTGGGGGAGCCGGTGTGGACGGCTATATTGGCGGCAAATATTGGCGCGACCCTGGTTCATTTGCAGAAGGCAGCGGTGCCACTCGTTTCAAAGGGATATGTTATATTCTAGTATCTGCATATTTCTCCTTCGGTGGTATTGAATTATTTGTTCTTTCCATCAATGAGCAGTCTAACCCTAGAAAATCCACTCCTGTAGCCGCGAAGAGAAGTGTATATCGTATTTTGATCATTTATTTGCTGACAATGATTCTAATTGGGTTCAATGTTCCTCACAATAACGATCAATTGATGGGTTCCGGTGGCTCCGCAACGCACGCTTCACCATATGTCTTGGCAGCCTCTATTCACAAGGTTAGGGTCATCCCCCATATCATTAATGCTGTTATTTTGATATCAGTCATCTCTGTTGCGAACTCTGCCCTTTATGCCGCACCGAGATTAATGTGTTCCTTGGCTCAACAGGGCTATGCTCCAAAATTTTTGAACTATATTGATAGGGAGGGAAGACCTTTAAGGGCCTTGGTAGTGTGCTCTCTTGTTGGTGTCGTTGGCTTCGTCGCCTGTTCTCCACAGGAAGAGCAAGCATTTACATGGTTGGCAGCCATTGCAGGTTTGAGTGAACTTTTCACATGGTCAGGCATTATGCTTTCACACATTCGATTCAGAAAAGCGATGAAAGTCCAAGGAAGATCACTTGATGAAGTCGGCTATAAGGCCAATACCGGTATATGGGGTTCATACTATGGGGTTTTTTTCAATATGCTTGTCTTTATGGCCCAATTTTGGGTCGCACTGTCTCCAATAGGAAATGGCGGAAAGTGTGATGCTCAGGCATTCTTCGAGAGTTATCTGGCTGCCCCGCTATGGATATTCATGTATGTTGGATACATGGTTTACAAAAGAGATTTTACCTTTTTAAACCCACTGGACAAGATCGACTTGGACTTTCATAGAAGAGTTTACGACCCTGAAATAATGAGGCAGGAGGACGAAGAAAATAAAGAAAGGTTAAAGAACTCTTCAATATTCGTCAGAGTCTACAAATTTTGGTGTTAG","protein_sequence":"MSDPIVTSSKMEKSAEFEVTDSALYNNFNTSTTASLTPEIKEHSEESRNGLVHRFVDSFRRAESQRLEEDNDLEDGTKSMKSNNHLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLSLAGPGSLVIGYVMVSFVTYFMVQAAGEMGVTYPTLPGNFNAYNSIFISKSFGFATTWLFCIQWLTVLPLELITSSMTVKYWNDTINADVFIVIFYVFLLFIHFFGVKAYGETEFIFNSCKILMVAGFIILSVVINCGGAGVDGYIGGKYWRDPGSFAEGSGATRFKGICYILVSAYFSFGGIELFVLSINEQSNPRKSTPVAAKRSVYRILIIYLLTMILIGFNVPHNNDQLMGSGGSATHASPYVLAASIHKVRVIPHIINAVILISVISVANSALYAAPRLMCSLAQQGYAPKFLNYIDREGRPLRALVVCSLVGVVGFVACSPQEEQAFTWLAAIAGLSELFTWSGIMLSHIRFRKAMKVQGRSLDEVGYKANTGIWGSYYGVFFNMLVFMAQFWVALSPIGNGGKCDAQAFFESYLAAPLWIFMYVGYMVYKRDFTFLNPLDKIDLDFHRRVYDPEIMRQEDEENKERLKNSSIFVRVYKFWC"},{"created_at":"2011-05-26T17:45:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"General amino acid permease AGP1","uniprot_id":"P25376","uniprot_name":"AGP1_YEAST","enzyme":false,"transporter":true,"gene_name":"AGP1","num_residues":633,"molecular_weight":"69670.70313","theoretical_pi":"6.97","general_function":"Involved in transport","specific_function":"Broad substrate range permease which transports asparagine and glutamine with intermediate specificity. Also transports Ala, Cys, Gly, Ile, Leu, Met, Phe, Ser, Thr, Tyr and Val. Important for the utilization of amino acids as a nitrogen source","reactions":[],"signal_regions":"None","transmembrane_regions":"125-145;149-169;198-218;232-252;261-281;314-334;353-373;403-425;453-473;478-498;532-552;561-581","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"AGP1","chromosome_location":"chromosome 3","locus":"YCL025C","synonyms":["Asparagine/glutamine permease"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCGTCGTCGAAGTCTCTATACGAACTGAAAGACTTGAAAAATAGCTCCACAGAAATACATGCCACGGGGCAGGATAATGAAATTGAATATTTCGAAACAGGCTCCAATGACCGTCCATCCTCACAACCTCATTTAGGTTACGAACAGCATAACACTTCTGCCGTGCGTAGGTTTTTCGACTCCTTTAAAAGAGCGGATCAGGGTCCACAGGATGAAGTAGAAGCAACACAAATGAACGATCTTACGTCGGCTATCTCACCTTCTTCTAGACAGGCTCAAGAACTAGAAAAAAATGAAAGTTCGGACAACATAGGCGCTAATACAGGTCATAAGTCGGACTCGCTGAAGAAAACCATTCAGCCTAGACATGTTCTGATGATTGCGTTGGGTACGGGTATCGGTACTGGGTTATTGGTCGGTAACGGTACCGCGTTGGTTCATGCGGGTCCAGCTGGACTACTTATTGGTTACGCTATTATGGGTTCTATCTTGTACTGTATTATTCAAGCATGTGGTGAAATGGCGCTAGTGTATAGTAACTTGACTGGTGGCTACAATGCATACCCCAGTTTCCTTGTGGATGATGGTTTTGGGTTTGCAGTCGCTTGGGTTTATTGTTTGCAATGGCTGTGTGTGTGTCCTCTGGAATTGGTGACCGCATCCATGACTATCAAATATTGGACGACATCTGTGAACCCGGATGTGTTCGTCATTATTTTCTATGTTTTGGTGATTACTATTAATATTTTCGGTGCTCGTGGTTATGCAGAAGCTGAGTTCTTCTTCAACTGTTGCAAAATTTTGATGATGACTGGGTTCTTCATTCTTGGTATTATCATCGATGTTGGTGGCGCTGGTAATGATGGTTTTATTGGTGGTAAATACTGGCACGATCCGGGCGCTTTCAATGGTAAACATGCCATTGACAGATTTAAAGGTGTTGCTGCAACATTAGTGACTGCTGCTTTTGCCTTTGGTGGTTCAGAGTTTATTGCCATCACCACTGCAGAACAATCTAATCCAAGAAAGGCCATTCCAGGTGCGGCCAAACAAATGATCTACAGAATCTTATTCCTATTCTTGGCTACCATTATTCTACTGGGTTTCTTGGTGCCATACAATTCCGATCAATTATTGGGTTCTACCGGTGGTGGTACTAAAGCCTCGCCATATGTCATTGCTGTTGCATCCCACGGTGTCCGTGTCGTCCCACACTTCATTAACGCCGTTATTCTACTTTCCGTGCTGTCCATGGCTAACTCCTCCTTCTACTCCAGTGCTCGTTTATTTTTAACTCTATCCGAGCAAGGTTACGCTCCTAAGGTTTTCTCCTACATCGACAGAGCCGGTAGACCATTGATTGCCATGGGTGTTTCTGCATTGTTTGCCGTTATTGCCTTCTGTGCTGCATCTCCCAAGGAAGAACAAGTTTTCACTTGGTTATTGGCCATTTCTGGTTTGTCTCAGCTTTTCACATGGACTGCCATTTGTTTATCCCATCTTAGATTTAGAAGAGCCATGAAAGTCCAAGGGAGATCTCTTGGAGAATTGGGTTTCAAATCTCAAACTGGTGTTTGGGGATCTGCCTACGCTTGCATTATGATGATTTTAATTCTTATTGCCCAATTTTGGGTCGCTATCGCCCCCATTGGTGAAGGTAAGCTGGATGCACAAGCCTTTTTCGAAAACTACTTGGCTATGCCAATCTTGATTGCACTTTATGTCGGCTACAAGGTCTGGCACAAGGATTGGAAACTGTTCATCAGGGCAGACAAGATCGACCTAGATTCTCATAGACAAATCTTTGATGAAGAATTAATCAAGCAAGAAGACGAAGAATATAGGGAACGTTTGAGGAACGGACCTTATTGGAAAAGGGTCGTTGCCTTCTGGTGTTAA","protein_sequence":"MSSSKSLYELKDLKNSSTEIHATGQDNEIEYFETGSNDRPSSQPHLGYEQHNTSAVRRFFDSFKRADQGPQDEVEATQMNDLTSAISPSSRQAQELEKNESSDNIGANTGHKSDSLKKTIQPRHVLMIALGTGIGTGLLVGNGTALVHAGPAGLLIGYAIMGSILYCIIQACGEMALVYSNLTGGYNAYPSFLVDDGFGFAVAWVYCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVIIFYVLVITINIFGARGYAEAEFFFNCCKILMMTGFFILGIIIDVGGAGNDGFIGGKYWHDPGAFNGKHAIDRFKGVAATLVTAAFAFGGSEFIAITTAEQSNPRKAIPGAAKQMIYRILFLFLATIILLGFLVPYNSDQLLGSTGGGTKASPYVIAVASHGVRVVPHFINAVILLSVLSMANSSFYSSARLFLTLSEQGYAPKVFSYIDRAGRPLIAMGVSALFAVIAFCAASPKEEQVFTWLLAISGLSQLFTWTAICLSHLRFRRAMKVQGRSLGELGFKSQTGVWGSAYACIMMILILIAQFWVAIAPIGEGKLDAQAFFENYLAMPILIALYVGYKVWHKDWKLFIRADKIDLDSHRQIFDEELIKQEDEEYRERLRNGPYWKRVVAFWC"},{"created_at":"2011-05-26T18:32:36.000Z","updated_at":"2011-05-27T15:01:04.000Z","name":"Phenylalanyl-tRNA synthetase, mitochondrial","uniprot_id":"P08425","uniprot_name":"SYFM_YEAST","enzyme":true,"transporter":false,"gene_name":"MSF1","num_residues":469,"molecular_weight":"54828.39844","theoretical_pi":"8.14","general_function":"Involved in nucleotide binding","specific_function":"Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins","reactions":[{"id":1840,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2537,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"Z49219","genbank_protein_id":"805030","gene_card_id":"MSF1","chromosome_location":"chromosome 16","locus":"YPR047W","synonyms":["Phenylalanine--tRNA ligase","PheRS"],"enzyme_classes":["6.1.1.20"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" tRNA binding"},{"category":"Function","description":" phenylalanine-tRNA ligase activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" tRNA processing"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" phenylalanyl-tRNA aminoacylation"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"}],"pfams":[{"name":"FDX-ACB","identifier":"PF03147"},{"name":"tRNA-synt_2d","identifier":"PF01409"}],"pathways":[],"gene_sequence":"ATGGAGGTAACTTCAATGTTTCTCAATAGAATGATGAAGACCAGGACTGGTCTTTATCGCTTATATTCAACCCTTAAAGTTCCACATGTAGAAATCAATGGCATAAAATACAAGACCGACCCACAGACTACCAATGTTACAGATTCAATAATAAAGCTTACCGACAGATCATTACATTTGAAAGAATCACATCCAGTAGGCATTCTTCGCGATCTAATTGAAAAGAAATTAAACTCAGTCGACAACACATTTAAGATCTTTAATAATTTCAAGCCCGTGGTAACCACAATGGAAAACTTCGATTCTTTAGGGTTTCCTAAGGATCATCCTGGAAGATCAAAATCTGACACATATTATATAAATGAGACGCACCTACTGAGAACACATACTTCAGCCCACGAATTAGAGTGCTTTCAAAAAATAAGAAACGATTCAGATAATATTAAAAGTGGATTTTTAATATCTGCAGATGTGTACAGAAGAGATGAAATTGACAAAACTCACTATCCGGTATTCCACCAAATGGAAGGAGCCACAATTTGGAAACGAACGAAGGCTGATGTGGGCGTAAAGGAGCCAATGTATATCGAGAAAATCCGTGAAGATATCAGACAGGTAGAGAACCTTTTAAATAAAGAAAATGTAAAGATTACGGTTGACGATGATACTATACCTTTGAAAGAAAATAATCCTAAACAAGAGTATATGTCCGATCTGGAGGTTGATTTGTGCTCTCAACATTTGAAGAGGTCCATTGAACTGATAGTTTCTGAAGTTTTTAACAAAAAAATATCTAGCATGATCAAGAACAAAGCGAATAATACACCCAAAGAGCTAAAAGTCCGTTGGATTAACGCTTACTTCCCCTGGACCGCGCCCTCATGGGAAATAGAGGTTTGGTGGCAGGGCGAATGGCTCGAACTCTGCGGATGCGGATTGATTCGTCAAGATGTGCTACTAAGAGCCGGATATAAACCTTCTGAAACAATTGGGTGGGCTTTTGGCTTGGGTTTGGACCGCATTGCTATGCTTCTTTTTGAAATTCCAGATATTAGACTGCTTTGGAGTCGTGATGAAAGATTTTCAAGACAATTCTCCAAGGGATTAATTACTTCCTTCAAACCTTATTCAAAACACCCGGGATCATTTAGGGATGTTGCGTTTTGGTTACCAGAAGATAAACCAGATATTCATCAAGTTCATGAAAATGATTTGATGGAAATTATCAGAAATATAGCTGGCGATTTGGTAGAGAGTGTCAAGCTAGTCGATAGCTTTACGCATCCGAAAACTGGGAGAAAATCTATGTGCTACAGGATCAACTATCAATCAATGGACAGAAATTTGACAAACGCCGAAGTTAACACTTTGCAAGACATGGTGTGTTCTAAATTGGTAAAAGAATACAGCGTAGAACTCAGATAG","protein_sequence":"MFLNRMMKTRTGLYRLYSTLKVPHVEINGIKYKTDPQTTNVTDSIIKLTDRSLHLKESHPVGILRDLIEKKLNSVDNTFKIFNNFKPVVTTMENFDSLGFPKDHPGRSKSDTYYINETHLLRTHTSAHELECFQKIRNDSDNIKSGFLISADVYRRDEIDKTHYPVFHQMEGATIWKRTKADVGVKEPMYIEKIREDIRQVENLLNKENVKITVDDDTIPLKENNPKQEYMSDLEVDLCSQHLKRSIELIVSEVFNKKISSMIKNKANNTPKELKVRWINAYFPWTAPSWEIEVWWQGEWLELCGCGLIRQDVLLRAGYKPSETIGWAFGLGLDRIAMLLFEIPDIRLLWSRDERFSRQFSKGLITSFKPYSKHPGSFRDVAFWLPEDKPDIHQVHENDLMEIIRNIAGDLVESVKLVDSFTHPKTGRKSMCYRINYQSMDRNLTNAEVNTLQDMVCSKLVKEYSVELR"},{"created_at":"2011-05-26T18:41:16.000Z","updated_at":"2011-05-27T15:01:05.000Z","name":"Phenylalanyl-tRNA synthetase beta chain","uniprot_id":"P15624","uniprot_name":"SYFB_YEAST","enzyme":true,"transporter":false,"gene_name":"FRS1","num_residues":595,"molecular_weight":"67364.29688","theoretical_pi":"5.55","general_function":"Involved in RNA binding","specific_function":"ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)","reactions":[{"id":2537,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X94607","genbank_protein_id":"1181281","gene_card_id":"FRS1","chromosome_location":"chromosome 12","locus":"YLR060W","synonyms":["Phenylalanine--tRNA ligase beta chain","PheRS"],"enzyme_classes":["6.1.1.20"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" phenylalanine-tRNA ligase activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" phenylalanyl-tRNA aminoacylation"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"}],"pfams":[{"name":"B3_4","identifier":"PF03483"},{"name":"B5","identifier":"PF03484"}],"pathways":[],"gene_sequence":"ATGCCTACCGTCTCCGTGAACAAGCAGCAATTATTTGATCTTCTAGGCAAAAACTACACTTCCCAAGAGTTCGATGAATTATGTTTTGAATTCGGTATGGAAATGGACGAAGACACCACAGAGGAGGCCTTGAAAACCGGGGAGGAGCCGGAATTGAAGCTTGATATCAGTGCCAATCGTTACGATTTGCTTTGTATCGAAGGTATTTCACAGTCGCTGAACGAATACTTGGAACGTAAAGAAAGACCTGACTATAAATTAAGCAAGCCAACCACTAAGTTGATCATCGACAAATCAACGGAGCAAATTAGACCTTTTGCTACCGCTGCTGTATTGAGAAATATCAAGCTTAACGAAAAATCTTACGCTTCTTTTATTGCCTTGCAAGATAAATTACATGCCAATCTATGTAGAAACAGAAGCTTGGTTGCCATGGGTACTCACGATTTAGATTCAATTGAAGGTCCATTCCATTACAGAGCTCTACCACCAAAGGACATCAAGTTCGTACCATTGAATCAAACCCAAGAGTTTACTGGTGACAAATTGATCGAGTTTTATAAATCTCCAGAACAGAAAAACAACATAGGGAGATACGTTCACATTATTGAGGATTCTCCAGTCTTCCCAGTTATTATGGACAGCAAAGATCGTGTTTGCTCCCTGCCACCATTAATCAATAGTGAACATTCGAAGATCTCTGTGAACACCCGTAACATTTTGATTGATATAACCGCCACCGATAAGACCAAAGCCGAGATCGTTTTGAACATATTAACTACAATGTTCTCACGTTATTGTGACGAACCATTCACGGTTGAGCCTGTAGAAATTGTCTCTGAACACAATGGCCAATCCCGTTTGGCGCCAAACTTCAACGATAGAATTATGGATGTCTCCATTAAGTACATCAACTCCTGTCTTGGCCTAGATCAATCCGCTGATGAAATTGCTCATTGTCTAAAGAAGATGTCGTTGCATGCCGTTCAATCAAAGGAAGACAAGGACATCTTGCACGTTGACATTCCGGTAACTAGACCTGATATTTTGCACGCTTGTGATATAATGGAAGATGCCGCTGTCGGTTATGGTTTCAATAATTTGCCAAAGGGTGAGAAATTATCCAATGCCAACTTCATTGCCAAACCATTACCAATCAACAAGGTTTCTGATATTTTCAGAGTTGCATCCTCTCAAGCCACGTGGGTTGAGGTTTTACCATTGACCTTATGTTCGCACGATGAAAACTTTAAATTTCTAAGACAATCCGACAATGGTGATTTAGCTGTCAAATTGGCCAACCCAAAGACTTTGGAATACCAAGTTGTTAGAACCACTTTATTGCCTGGTATCTTAAAGACAGTCAAGGAAAACAGAAAACATTCCTTGCCAATCAAAGTCTTTGAAACCGGTGACGTTGTATTTAAAGACGACAAACTAGAAAGGAAGGCGTACAATGAACGTCACTGGGCTGCCATCTACGTGGGTAAGAATTCTGGGTTTGAAATCATTCAAGGGTTATTGGGTAAAATCATGCAAACTTTTAGAACAGAGTGGATTGCAGACTACGGTGCTGCTGCTTCTGGCAGAGGTTACTGGATTGAAGAAGACGATTCTGTGAAAACCTACTTCCCAGGTAGAGGTGCCAAGGTCATGTTCAGATCCAAAGAAGGCGCTGAGCCAAAGCAAATCGGCCACTTGGGTGTCTTGCATCCTGAAGTCATGATGAATTTCGACGTTCCATTCGCTGCATCCTTTGTAGAGGTTAATGCCGAAGTCTTCCTATAA","protein_sequence":"MPTVSVNKQQLFDLLGKNYTSQEFDELCFEFGMEMDEDTTEEALKTGEEPELKLDISANRYDLLCIEGISQSLNEYLERKERPDYKLSKPTTKLIIDKSTEQIRPFATAAVLRNIKLNEKSYASFIALQDKLHANLCRNRSLVAMGTHDLDSIEGPFHYRALPPKDIKFVPLNQTQEFTGDKLIEFYKSPEQKNNIGRYVHIIEDSPVFPVIMDSKDRVCSLPPLINSEHSKISVNTRNILIDITATDKTKAEIVLNILTTMFSRYCDEPFTVEPVEIVSEHNGQSRLAPNFNDRIMDVSIKYINSCLGLDQSADEIAHCLKKMSLHAVQSKEDKDILHVDIPVTRPDILHACDIMEDAAVGYGFNNLPKGEKLSNANFIAKPLPINKVSDIFRVASSQATWVEVLPLTLCSHDENFKFLRQSDNGDLAVKLANPKTLEYQVVRTTLLPGILKTVKENRKHSLPIKVFETGDVVFKDDKLERKAYNERHWAAIYVGKNSGFEIIQGLLGKIMQTFRTEWIADYGAAASGRGYWIEEDDSVKTYFPGRGAKVMFRSKEGAEPKQIGHLGVLHPEVMMNFDVPFAASFVEVNAEVFL"},{"created_at":"2011-05-26T18:44:15.000Z","updated_at":"2011-05-29T05:06:23.000Z","name":"Phenylalanyl-tRNA synthetase alpha chain","uniprot_id":"P15625","uniprot_name":"SYFA_YEAST","enzyme":true,"transporter":false,"gene_name":"FRS2","num_residues":503,"molecular_weight":"57511.0","theoretical_pi":"5.53","general_function":"Involved in nucleotide binding","specific_function":"ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)","reactions":[{"id":2537,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"D50617","genbank_protein_id":"836732","gene_card_id":"FRS2","chromosome_location":"chromosome 6","locus":"YFL022C","synonyms":["Phenylalanine--tRNA ligase alpha chain","PheRS"],"enzyme_classes":["6.1.1.20"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" tRNA binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" phenylalanine-tRNA ligase activity"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" phenylalanyl-tRNA aminoacylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"}],"pfams":[{"name":"tRNA-synt_2d","identifier":"PF01409"}],"pathways":[],"gene_sequence":"ATGTCTGATTTCCAATTAGAAATTCTAAAAAAACTAGATGAATTGGATGAGATCAAGTCCACACTGGCAACTTTCCCTCAGCACGGCTCTCAAGATGTTCTTTCCGCTTTGAACTCTTTGAAAGCCCACAACAAGTTAGAGTTTTCCAAGGTCGACACGGTTACGTATGACTTGACCAAAGAAGGTGCTCAAATTTTGAATGAAGGTTCGTACGAAATTAAACTAGTCAAGCTCATCCAAGAGTTGGGTCAACTTCAAATCAAAGATGTGATGTCCAAACTGGGTCCTCAAGTTGGTAAGGTCGGTCAGGCTAGAGCTTTCAAGAACGGCTGGATCGCCAAAAACGCCTCAAACGAGCTTGAACTCTCCGCAAAATTGCAAAATACCGATTTAAATGAGCTTACTGATGAAACGCAATCTATTCTAGCGCAAATCAAGAACAACTCGCATCTGGATAGCATTGACGCCAAGATTTTGAACGACTTGAAGAAAAGAAAGTTAATTGCTCAAGGTAAAATCACAGATTTCAACGTTACCAAAGGGCCAGAGTTCTCGACCGACCTCACCAAATTGGAAACCGATCTTACCTCCGACATGGTCTCCACCAATGCATACAAGGACTTGAAGTTCAAGCCTTACAATTTCAATTCTCAAGGTGTGCAAATATCTTCAGGTGCTCTTCACCCCTTAAACAAAGTCAGAGAGGAATTTAGACAAATTTTCTTTTCCATGGGATTCACAGAGATGCCCTCGAACCAATACGTCGAGACAGGTTTCTGGAACTTCGATGCCCTTTACGTCCCACAACAGCATCCTGCTCGTGACCTGCAAGACACTTTCTACATCAAGGACCCACTAACCGCTGACTTGCCCGATGACAAGACATACATGGACAATATCAAAGCCGTTCACGAACAGGGGAGATTCGGGTCCATCGGTTATCGTTACAACTGGAAGCCAGAAGAATGTCAAAAATTGGTCTTGAGAACTCACTCCACAGCCATCTCTGCCAGAATGCTGCACGATTTGGCCAAAGATCCAAAGCCCACCAGATTGTTTTCTATCGACCGTGTTTTCCGTAACGAAGCAGTTGACGCCACCCATTTGGCCGAATTCCACCAGGTGGAAGGTGTTCTTGCCGACTACAACATTACTCTGGGTGACCTGATCAAGTTCATGGAAGAGTTTTTCGAAAGAATGGGTGTCACCGGTTTGAGATTCAAGCCTACCTACAATCCTTACACCGAGCCATCAATGGAAATCTTTTCTTGGCACGAAGGTTTGCAAAAATGGGTCGAAATCGGTAACTCTGGTATGTTCAGACCAGAAATGCTCGAGTCCATGGGTCTACCAAAGGATCTAAGAGTCCTTGGTTGGGGGTTATCCTTGGAAAGACCTACCATGATCAAATATAAGGTTCAAAACATCAGAGAACTGTTAGGTCATAAAGTCTCTTTGGACTTTATCGAAACCAATCCTGCTGCTAGATTGGACGAAGACTTGTACGAATAA","protein_sequence":"MSDFQLEILKKLDELDEIKSTLATFPQHGSQDVLSALNSLKAHNKLEFSKVDTVTYDLTKEGAQILNEGSYEIKLVKLIQELGQLQIKDVMSKLGPQVGKVGQARAFKNGWIAKNASNELELSAKLQNTDLNELTDETQSILAQIKNNSHLDSIDAKILNDLKKRKLIAQGKITDFNVTKGPEFSTDLTKLETDLTSDMVSTNAYKDLKFKPYNFNSQGVQISSGALHPLNKVREEFRQIFFSMGFTEMPSNQYVETGFWNFDALYVPQQHPARDLQDTFYIKDPLTADLPDDKTYMDNIKAVHEQGRFGSIGYRYNWKPEECQKLVLRTHSTAISARMLHDLAKDPKPTRLFSIDRVFRNEAVDATHLAEFHQVEGVLADYNITLGDLIKFMEEFFERMGVTGLRFKPTYNPYTEPSMEIFSWHEGLQKWVEIGNSGMFRPEMLESMGLPKDLRVLGWGLSLERPTMIKYKVQNIRELLGHKVSLDFIETNPAARLDEDLYE"},{"created_at":"2011-05-27T02:15:50.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Aromatic amino acid aminotransferase 2","uniprot_id":"P38840","uniprot_name":"ARO9_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO9","num_residues":513,"molecular_weight":"58527.0","theoretical_pi":"5.16","general_function":"Involved in transferase activity, transferring nitrogenous groups","specific_function":"Has aromatic amino acid transaminase activity and kynurenine aminotransferase activity","reactions":[{"id":1839,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2024,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2027,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2667,"direction":"\u003e","locations":"Cytoplasm","altext":"An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3787,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006309","source":"Smpdb"},{"id":3788,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006518","source":"Smpdb"},{"id":3789,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006523","source":"Smpdb"},{"id":3790,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006536","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U10398","genbank_protein_id":"500670","gene_card_id":"ARO9","chromosome_location":"chromosome 8","locus":"YHR137W","synonyms":["Aromatic amino acid aminotransferase II","Aromatic amino acid-requiring protein 9"],"enzyme_classes":["2.6.1.57"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACTGCTGGTTCTGCCCCCCCTGTTGATTACACTTCCTTAAAGAAGAACTTCCAACCGTTTCTCTCCAGAAGAGTAGAAAATAGATCTCTGAAAAGCTTTTGGGATGCTTCTGATATCTCAGATGACGTCATTGAGCTAGCTGGTGGAATGCCAAACGAGAGATTTTTTCCTATCGAATCTATGGATTTGAAAATATCAAAAGTTCCTTTTAATGATAACCCAAAATGGCATAATTCGTTTACCACGGCGCATTTGGACTTGGGATCCCCCAGTGAGCTACCCATTGCACGTTCTTTCCAATATGCAGAAACCAAGGGTTTACCCCCTCTCTTACATTTTGTTAAAGATTTTGTGTCCAGAATTAATCGCCCAGCCTTTTCCGATGAGACGGAGTCTAACTGGGATGTCATCCTTTCTGGCGGGTCCAACGATTCAATGTTTAAGGTTTTTGAAACAATTTGCGACGAATCGACCACTGTGATGATTGAAGAGTTTACTTTCACCCCGGCTATGTCCAATGTGGAGGCTACAGGAGCAAAAGTCATCCCCATCAAGATGAACCTGACCTTCGACAGAGAGTCCCAGGGTATTGATGTCGAATATCTAACGCAGTTGCTCGATAATTGGTCAACTGGACCATACAAAGACTTAAACAAGCCAAGGGTCCTATATACCATTGCAACGGGCCAAAATCCTACCGGGATGTCTGTCCCCCAGTGGAAAAGAGAGAAAATTTACCAGTTGGCCCAAAGACACGATTTCCTCATTGTTGAAGATGATCCCTACGGTTATCTGTACTTTCCTTCCTATAATCCGCAAGAGCCATTAGAAAACCCTTACCATTCTAGCGACCTGACTACTGAACGGTATTTGAATGATTTTTTAATGAAATCATTCTTGACTTTGGATACAGATGCCCGTGTCATCCGTTTGGAGACTTTTTCTAAAATTTTTGCTCCTGGATTAAGGTTATCCTTCATCGTTGCTAATAAATTCCTTTTGCAAAAAATCTTGGATTTGGCCGACATTACTACAAGGGCCCCCAGTGGTACCTCACAAGCTATTGTTTATTCTACAATAAAGGCAATGGCTGAGTCCAACTTATCGTCCTCTCTTTCTATGAAAGAAGCAATGTTTGAGGGTTGGATAAGATGGATAATGCAGATTGCTTCTAAATACAATCATAGGAAAAATCTTACTTTGAAAGCCTTATACGAAACAGAATCTTACCAAGCTGGTCAGTTTACCGTTATGGAACCCTCCGCGGGTATGTTCATCATTATTAAAATCAATTGGGGGAATTTCGATAGACCTGACGATTTGCCGCAACAGATGGATATTTTAGATAAGTTCTTGCTGAAGAATGGTGTTAAAGTAGTGCTTGGTTATAAAATGGCTGTTTGCCCAAATTATTCAAAGCAGAATTCAGATTTTCTAAGACTCACCATCGCCTATGCAAGGGATGATGATCAGTTGATTGAAGCTTCCAAAAGAATCGGTAGTGGCATAAAAGAATTTTTTGACAACTATAAAAGTTGA","protein_sequence":"MTAGSAPPVDYTSLKKNFQPFLSRRVENRSLKSFWDASDISDDVIELAGGMPNERFFPIESMDLKISKVPFNDNPKWHNSFTTAHLDLGSPSELPIARSFQYAETKGLPPLLHFVKDFVSRINRPAFSDETESNWDVILSGGSNDSMFKVFETICDESTTVMIEEFTFTPAMSNVEATGAKVIPIKMNLTFDRESQGIDVEYLTQLLDNWSTGPYKDLNKPRVLYTIATGQNPTGMSVPQWKREKIYQLAQRHDFLIVEDDPYGYLYFPSYNPQEPLENPYHSSDLTTERYLNDFLMKSFLTLDTDARVIRLETFSKIFAPGLRLSFIVANKFLLQKILDLADITTRAPSGTSQAIVYSTIKAMAESNLSSSLSMKEAMFEGWIRWIMQIASKYNHRKNLTLKALYETESYQAGQFTVMEPSAGMFIIIKINWGNFDRPDDLPQQMDILDKFLLKNGVKVVLGYKMAVCPNYSKQNSDFLRLTIAYARDDDQLIEASKRIGSGIKEFFDNYKS"},{"created_at":"2011-05-27T02:16:21.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Aromatic amino acid aminotransferase 1","uniprot_id":"P53090","uniprot_name":"ARO8_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO8","num_residues":500,"molecular_weight":"56177.30078","theoretical_pi":"5.86","general_function":"Involved in transferase activity, transferring nitrogenous groups","specific_function":"Has aromatic amino acid transaminase activity. Also active with methionine, alpha-aminoadipate and leucine when phenylpyruvate is the amino acceptor","reactions":[{"id":1839,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2024,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2027,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2667,"direction":"\u003e","locations":"Cytoplasm","altext":"An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2668,"direction":"\u003e","locations":"Cytoplasm","altext":"L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate","export":false,"pw_reaction_id":null,"source":null},{"id":14093,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006519","source":"Smpdb"},{"id":14094,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006524","source":"Smpdb"},{"id":14095,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006535","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692962","genbank_protein_id":"51013375","gene_card_id":"ARO8","chromosome_location":"chromosome 7","locus":"YGL202W","synonyms":["Aromatic amino acid aminotransferase I","Aromatic amino acid-requiring protein 8"],"enzyme_classes":["2.6.1.57","2.6.1.39"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACTTTACCTGAATCAAAAGACTTTTCTTACTTGTTTTCGGATGAAACCAATGCTCGTAAACCATCCCCATTGAAAACCTGCATCCATCTTTTCCAAGATCCTAACATTATCTTTTTGGGTGGTGGCCTGCCATTAAAAGATTATTTCCCATGGGATAATCTATCTGTAGATTCACCCAAGCCTCCTTTTCCCCAGGGTATTGGAGCTCCAATTGACGAGCAGAATTGCATAAAATACACCGTCAACAAAGATTACGCTGATAAAAGTGCCAATCCTTCCAACGATATTCCTTTGTCAAGAGCTTTGCAATACGGGTTCAGTGCTGGTCAACCTGAACTATTAAACTTCATTAGAGATCATACCAAGATTATCCACGATTTGAAGTATAAGGACTGGGACGTTTTAGCCACTGCAGGTAACACAAATGCCTGGGAATCTACTTTAAGAGTCTTTTGTAACCGAGGTGATGTCATCTTAGTTGAGGCACATTCTTTTTCCTCTTCATTGGCTTCTGCAGAGGCTCAAGGTGTCATTACCTTCCCCGTGCCAATTGACGCTGATGGTATCATTCCTGAAAAATTAGCTAAAGTCATGGAAAACTGGACACCTGGTGCTCCTAAACCAAAGTTGTTATACACTATTCCAACGGGCCAAAATCCAACTGGTACTTCCATTGCAGACCATAGAAAGGAGGCAATTTACAAGATCGCTCAAAAGTACGACTTCCTAATTGTGGAAGATGAACCTTATTATTTCTTACAAATGAATCCCTACATCAAAGACTTGAAGGAAAGAGAGAAGGCACAAAGTTCTCCAAAGCAGGACCATGACGAATTTTTGAAGTCCTTGGCAAACACTTTCCTTTCCTTGGATACAGAAGGCCGTGTTATTAGAATGGATTCCTTTTCAAAAGTTTTGGCCCCAGGGACAAGATTGGGTTGGATTACTGGTTCATCCAAAATCTTGAAGCCTTACTTGAGTTTGCATGAAATGACGATTCAAGCCCCAGCAGGTTTTACACAAGTTTTGGTCAACGCTACGCTATCCAGGTGGGGTCAAAAGGGTTACTTGGACTGGTTGCTTGGCCTGCGTCATGAATACACTTTGAAACGTGACTGTGCCATCGATGCCCTTTACAAGTATCTACCACAATCTGATGCTTTCGTGATCAATCCTCCAATTGCAGGTATGTTTTTCACCGTGAACATTGACGCATCTGTCCACCCTGAGTTTAAAACAAAATACAACTCAGACCCTTACCAGCTAGAACAGAGTCTTTACCACAAAGTGGTTGAACGTGGTGTTTTAGTGGTTCCCGGTTCTTGGTTCAAGAGTGAGGGTGAGACGGAACCTCCTCAACCCGCTGAATCTAAAGAAGTCAGTAATCCAAACATAATTTTCTTCAGAGGTACCTATGCAGCTGTCTCTCCTGAGAAACTGACTGAAGGTCTGAAGAGATTAGGTGATACTTTATACGAAGAATTTGGTATTTCCAAATAG","protein_sequence":"MTLPESKDFSYLFSDETNARKPSPLKTCIHLFQDPNIIFLGGGLPLKDYFPWDNLSVDSPKPPFPQGIGAPIDEQNCIKYTVNKDYADKSANPSNDIPLSRALQYGFSAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNAWESTLRVFCNRGDVILVEAHSFSSSLASAEAQGVITFPVPIDADGIIPEKLAKVMENWTPGAPKPKLLYTIPTGQNPTGTSIADHRKEAIYKIAQKYDFLIVEDEPYYFLQMNPYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLDTEGRVIRMDSFSKVLAPGTRLGWITGSSKILKPYLSLHEMTIQAPAGFTQVLVNATLSRWGQKGYLDWLLGLRHEYTLKRDCAIDALYKYLPQSDAFVINPPIAGMFFTVNIDASVHPEFKTKYNSDPYQLEQSLYHKVVERGVLVVPGSWFKSEGETEPPQPAESKEVSNPNIIFFRGTYAAVSPEKLTEGLKRLGDTLYEEFGISK"}]}