{"ymdb_id":"YMDB00303","created_at":"2011-05-29T18:04:07.000Z","updated_at":"2016-09-08T18:35:19.000Z","name":"Thiosulfate","cas":"14383-50-7","state":"Solid","melting_point":"48 oC","description":"Thiosulfate is a substrate for the mitochondrial enzyme thiosulfate reductase in the thiosulfate disproportionation pathway. In this reaction, thiosulfate is converted to sulfite and sulfide. [Biocyc PWY-5277]","experimental_water_solubility":"861 mg/mL [HMP experimental]","experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":"Serikova, E. A.; Racheva, I. V. Method for producing sodium thiosulfate.  U.S.S.R.  (1986), CODEN: URXXAF  SU  1279954  A1  19861230  Patent  written in Russian.  ","chebi_id":"16094","hmdb_id":"HMDB00257","kegg_id":"C00320","pubchem_id":"439208","cs_id":"1054","foodb_id":null,"wikipedia_link":"Thiosulfate","biocyc_id":"S2O3","iupac":"sulfanesulfonic acid","traditional_iupac":"sulfurothioic S-acid","logp":"-0.09597100366666667","pka":null,"alogps_solubility":null,"alogps_logp":null,"alogps_logs":null,"acceptor_count":"3","donor_count":"2","rotatable_bond_count":"0","polar_surface_area":"54.370000000000005","refractivity":"17.762","polarizability":"8.286479945990871","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":null,"pka_strongest_acidic":"-2.2786550993851344","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["Hyposulfite","S-hydril","Sodium hyposulfite","Sodium thiosulfate","Sodium thiosulfate anhydrous","Sulfactol","Thiosulfate","Thiosulfate ion","Thiosulfic acid","thiosulfuric acid","Thiosulphate"],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."}],"proteins":[{"created_at":"2011-05-26T17:18:06.000Z","updated_at":"2011-05-26T17:18:06.000Z","name":"Putative thiosulfate sulfurtransferase","uniprot_id":"Q08686","uniprot_name":"THTR_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":304,"molecular_weight":"34218.60156","theoretical_pi":"5.93","general_function":"Involved in thiosulfate sulfurtransferase activity","specific_function":"Thiosulfate + cyanide = sulfite + thiocyanate","reactions":[{"id":2471,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm;Mitochondrion","altext":"Thiosulfate + cyanide = sulfite + thiocyanate.","export":false,"pw_reaction_id":null,"source":null},{"id":14422,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006935","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Cytoplasm","genbank_gene_id":"AY692732","genbank_protein_id":"51012915","gene_card_id":null,"chromosome_location":null,"locus":"YOR251C","synonyms":[],"enzyme_classes":["2.8.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring sulfur-containing groups"},{"category":"Function","description":" sulfurtransferase activity"},{"category":"Function","description":" thiosulfate sulfurtransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" anion transport"},{"category":"Process","description":" inorganic anion transport"},{"category":"Process","description":" sulfate transport"}],"pfams":[{"name":"Rhodanese","identifier":"PF00581"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGCCATTATTTGATCTTATTTCTCCAAAAGCGTTTGTTAAGTTAGTGGCCAGTGAGAAGGTTCATAGAATCGTTCCAGTTGATGCAACATGGTACCTACCCAGTTGGAAGCTTGATAATAAAGTGGATTTCTTGACCAAACCACGTATACCAAACTCCATTTTCTTTGATATTGATGCAATCAGTGACAAAAAATCGCCCTATCCACATATGTTCCCTACAAAGAAGGTTTTTGACGACGCTATGAGTAATTTAGGAGTTCAAAAAGATGATATATTAGTGGTTTACGATCGTGTTGGTAACTTTAGCTCCCCTAGATGTGCTTGGACATTAGGAGTGATGGGACATCCTAAGGTGTACTTACTAAATAATTTCAACCAGTACAGAGAGTTTAAGTACCCTCTAGATTCCTCTAAGGTGGCAGCGTTTTCACCCTATCCAAAGAGTCATTATGAGTCCTCAGAAAGTTTCCAAGACAAGGAGATTGTAGACTATGAGGAAATGTTCCAATTGGTAAAGAGTGGGGAACTGGCTAAGAAATTCAATGCTTTCGATGCAAGGTCGCTCGGTAGATTCGAAGGTACAGAACCAGAGCCTCGTTCCGACATTCCATCGGGGCATATTCCAGGTACCCAACCATTACCATATGGAAGTTTACTTGATCCGGAGACCAAAACGTACCCAGAAGCTGGGGAGGCGATACACGCTACTTTGGAAAAGGCATTGAAAGACTTTCATTGCACTTTGGACCCAAGTAAACCAACTATTTGCTCTTGTGGAACTGGCGTTTCAGGAGTCATTATCAAGACAGCATTGGAGCTAGCAGGAGTTCCCAATGTTAGATTATATGATGGATCCTGGACCGAGTGGGTCTTGAAATCCGGGCCCGAGTGGATTGCTGAAAACAGAGATTAA","protein_sequence":"MPLFDLISPKAFVKLVASEKVHRIVPVDATWYLPSWKLDNKVDFLTKPRIPNSIFFDIDAISDKKSPYPHMFPTKKVFDDAMSNLGVQKDDILVVYDRVGNFSSPRCAWTLGVMGHPKVYLLNNFNQYREFKYPLDSSKVAAFSPYPKSHYESSESFQDKEIVDYEEMFQLVKSGELAKKFNAFDARSLGRFEGTEPEPRSDIPSGHIPGTQPLPYGSLLDPETKTYPEAGEAIHATLEKALKDFHCTLDPSKPTICSCGTGVSGVIIKTALELAGVPNVRLYDGSWTEWVLKSGPEWIAENRD"},{"created_at":"2011-05-26T17:18:32.000Z","updated_at":"2011-05-26T17:18:32.000Z","name":"Putative thiosulfate sulfurtransferase FMP31, mitochondrial","uniprot_id":"Q08742","uniprot_name":"FMP31_YEAST","enzyme":true,"transporter":false,"gene_name":"FMP31","num_residues":149,"molecular_weight":"16697.19922","theoretical_pi":"10.26","general_function":"Inorganic ion transport and metabolism","specific_function":"Thiosulfate + cyanide = sulfite + thiocyanate","reactions":[{"id":2471,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm;Mitochondrion","altext":"Thiosulfate + cyanide = sulfite + thiocyanate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY692684","genbank_protein_id":"51012819","gene_card_id":"FMP31","chromosome_location":null,"locus":"YOR286W","synonyms":["Found in mitochondrial proteome protein 31"],"enzyme_classes":["2.8.1.1"],"go_classes":[],"pfams":[{"name":"Rhodanese","identifier":"PF00581"}],"pathways":[],"gene_sequence":"ATGTTCAAGCATAGTACAGGTATTCTCTCGAGGACAGTTTCTGCAAGATCGCCTACATTGGTCCTGAGAACATTTACAACGAAGGCTCCAAAGATCTATACTTTTGACCAGGTCAGGAACCTAGTCGAACACCCCAATGATAAAAAACTATTGGTAGATGTAAGGGAACCCAAGGAAGTAAAGGATTACAAGATGCCAACTACAATAAATATTCCGGTGAATAGTGCCCCTGGCGCTCTTGGATTGCCCGAAAAGGAGTTTCACAAAGTTTTCCAATTTGCTAAACCACCTCACGATAAAGAATTGATTTTTCTTTGTGCGAAAGGAGTAAGAGCCAAAACTGCCGAAGAGTTGGCTCGATCTTATGGGTACGAAAACACTGGTATCTATCCTGGTTCTATTACTGAGTGGTTAGCTAAAGGTGGTGCTGACGTTAAGCCCAAAAAATAA","protein_sequence":"MFKHSTGILSRTVSARSPTLVLRTFTTKAPKIYTFDQVRNLVEHPNDKKLLVDVREPKEVKDYKMPTTINIPVNSAPGALGLPEKEFHKVFQFAKPPHDKELIFLCAKGVRAKTAEELARSYGYENTGIYPGSITEWLAKGGADVKPKK"},{"created_at":"2011-05-26T17:18:56.000Z","updated_at":"2011-05-26T17:18:56.000Z","name":"Putative thiosulfate sulfurtransferase YOR285W","uniprot_id":"Q12305","uniprot_name":"YO285_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":139,"molecular_weight":"15413.2002","theoretical_pi":"6.35","general_function":"Inorganic ion transport and metabolism","specific_function":"Thiosulfate + cyanide = sulfite + thiocyanate","reactions":[{"id":2471,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm;Mitochondrion","altext":"Thiosulfate + cyanide = sulfite + thiocyanate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"X89633","genbank_protein_id":"1279709","gene_card_id":null,"chromosome_location":null,"locus":"YOR285W","synonyms":[],"enzyme_classes":["2.8.1.1"],"go_classes":[],"pfams":[{"name":"Rhodanese","identifier":"PF00581"}],"pathways":[],"gene_sequence":"ATGTGGAAGGCCGTGATGAATGCTTGGAATGGAACCGAGAGTCAAAGTAAGAATGTTTCAAATATTCAATCTTACAGTTTTGAAGACATGAAAAGAATCGTTGGAAAGCATGATCCTAATGTGGTTTTGGTAGATGTTAGAGAACCATCTGAGTACTCGATTGTTCATATTCCTGCTTCCATCAATGTGCCATATAGATCGCACCCTGACGCATTTGCCTTAGATCCTTTAGAATTTGAGAAACAGATTGGCATCCCAAAACCTGACAGTGCCAAGGAGCTAATATTTTATTGTGCTTCTGGCAAACGCGGGGGAGAAGCTCAAAAAGTCGCCTCCTCACATGGATATTCAAACACCTCACTATATCCTGGCTCTATGAATGATTGGGTTTCTCATGGGGGTGATAAACTTGACTTATAG","protein_sequence":"MWKAVMNAWNGTESQSKNVSNIQSYSFEDMKRIVGKHDPNVVLVDVREPSEYSIVHIPASINVPYRSHPDAFALDPLEFEKQIGIPKPDSAKELIFYCASGKRGGEAQKVASSHGYSNTSLYPGSMNDWVSHGGDKLDL"},{"created_at":"2011-05-27T07:28:41.000Z","updated_at":"2011-05-29T05:06:46.000Z","name":"Cytochrome c iso-1","uniprot_id":"P00044","uniprot_name":"CYC1_YEAST","enzyme":true,"transporter":false,"gene_name":"CYC1","num_residues":109,"molecular_weight":"12181.90039","theoretical_pi":"9.96","general_function":"Involved in iron ion binding","specific_function":"Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain","reactions":[{"id":14426,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006939","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"2PCC","cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"L26347","genbank_protein_id":"695795","gene_card_id":"CYC1","chromosome_location":"chromosome 10","locus":"YJR048W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" electron carrier activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Cytochrom_C","identifier":"PF00034"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGACTGAATTCAAGGCCGGTTCTGCTAAGAAAGGTGCTACACTTTTCAAGACTAGATGTCTACAATGCCACACCGTGGAAAAGGGTGGCCCACATAAGGTTGGTCCAAACTTGCATGGTATCTTTGGCAGACACTCTGGTCAAGCTGAAGGGTATTCGTACACAGATGCCAATATCAAGAAAAACGTGTTGTGGGACGAAAATAACATGTCAGAGTACTTGACTAACCCAAAGAAATATATTCCTGGTACCAAGATGGCCTTTGGTGGGTTGAAGAAGGAAAAAGACAGAAACGACTTAATTACCTACTTGAAAAAAGCCTGTGAGTAA","protein_sequence":"MTEFKAGSAKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGIFGRHSGQAEGYSYTDANIKKNVLWDENNMSEYLTNPKKYIPGTKMAFGGLKKEKDRNDLITYLKKACE"},{"created_at":"2011-05-27T07:29:16.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"Cytochrome c iso-2","uniprot_id":"P00045","uniprot_name":"CYC7_YEAST","enzyme":true,"transporter":false,"gene_name":"CYC7","num_residues":113,"molecular_weight":"12532.2998","theoretical_pi":"10.18","general_function":"Involved in iron ion binding","specific_function":"Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain","reactions":[{"id":14426,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006939","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1YEA","cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"AY693032","genbank_protein_id":"51013515","gene_card_id":"CYC7","chromosome_location":"chromosome 5","locus":"YEL039C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" electron carrier activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Cytochrom_C","identifier":"PF00034"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGGCTAAAGAAAGTACGGGATTCAAACCAGGCTCTGCAAAAAAGGGTGCTACATTGTTTAAAACGAGGTGTCAGCAGTGTCATACAATAGAAGAGGGTGGTCCTAACAAAGTTGGACCTAATTTACATGGTATTTTTGGTAGACATTCAGGTCAGGTAAAGGGTTATTCTTACACAGATGCAAACATCAACAAGAACGTCAAATGGGATGAGGATAGTATGTCCGAGTACTTGACGAACCCAAAGAAATATATTCCTGGTACCAAGATGGCGTTTGCCGGGTTGAAGAAGGAAAAGGACAGAAACGATTTAATTACTTATATGACAAAGGCTGCCAAATAG","protein_sequence":"MAKESTGFKPGSAKKGATLFKTRCQQCHTIEEGGPNKVGPNLHGIFGRHSGQVKGYSYTDANINKNVKWDEDSMSEYLTNPKKYIPGTKMAFAGLKKEKDRNDLITYMTKAAK"}]}