{"ymdb_id":"YMDB00297","created_at":"2011-05-29T18:03:28.000Z","updated_at":"2016-09-08T18:35:18.000Z","name":"S-Adenosylmethionine","cas":"29908-03-0","state":"Solid","melting_point":"","description":"S-Adenosyl-L-methionine (SAM) is a common co-substrate involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase [EC 2.5.1.6]. SAM is involved in transmethylation, transsulfuration, and aminopropylation metabolic pathways.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"extracellular;mitochondrion;endoplasmic reticulum;cytoplasm","synthesis_reference":"Lin, Jian-Ping; Tian, Jun; You, Jian-Feng; Jin, Zhi-Hua; Xu, Zhi-Nan; Cen, Pei-Lin. An effective strategy for the co-production of S-adenosyl-L-methionine and glutathione by fed-batch fermentation. Biochemical Engineering Journal (2004), 21(1), 19-25.","chebi_id":"15414","hmdb_id":"HMDB01185","kegg_id":"C00019","pubchem_id":"1079","cs_id":"21865164","foodb_id":null,"wikipedia_link":"S-Adenosyl_methionine","biocyc_id":"S-ADENOSYLMETHIONINE","iupac":"[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium","traditional_iupac":"SAMe","logp":"-5.318663457073791","pka":"12.444250657541687","alogps_solubility":"1.19e+00 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(1969). \"Genetic and regulatory aspects of methionine biosynthesis in Saccharomyces cerevisiae.\" J Bacteriol 97:328-336."},{"pubmed_id":18625006,"citation":"Pirkov, I., Norbeck, J., Gustafsson, L., Albers, E. (2008). \"A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.\" FEBS J 275:4111-4120."}],"proteins":[{"created_at":"2011-05-24T20:15:20.000Z","updated_at":"2011-07-22T17:54:38.000Z","name":"Diphthine synthase","uniprot_id":"P32469","uniprot_name":"DPH5_YEAST","enzyme":true,"transporter":false,"gene_name":"DPH5","num_residues":300,"molecular_weight":"33847.0","theoretical_pi":"4.56","general_function":"Involved in methyltransferase activity","specific_function":"Required for the methylation step in diphthamide biosynthesis","reactions":[{"id":1470,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2307,"direction":"\u003e","locations":"Cytoplasm","altext":"3 S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = 3 S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY557947","genbank_protein_id":"45269786","gene_card_id":"DPH5","chromosome_location":"chromosome 12","locus":"YLR172C","synonyms":["Diphthamide biosynthesis methyltransferase"],"enzyme_classes":["2.1.1.98"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" S-adenosylmethionine-dependent methyltransferase activity"},{"category":"Function","description":" diphthine synthase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" peptidyl-amino acid modification"},{"category":"Process","description":" peptidyl-histidine modification"},{"category":"Process","description":" peptidyl-diphthamide metabolic process"},{"category":"Process","description":" peptidyl-diphthamide biosynthetic process from peptidyl-histidine"}],"pfams":[{"name":"TP_methylase","identifier":"PF00590"}],"pathways":[],"gene_sequence":"ATGCTTTATTTGATCGGACTTGGTCTCTCGTACAAATCAGACATTACCGTTCGTGGTTTGGAAGCTATTAAGAAATGTTCTAGAGTTTATCTAGAACACTATACCAGTATCCTAATGGCTGCAAGCCAAGAAGAGTTAGAATCTTACTATGGTAAAGAGATCATCTTGGCTGATAGGGAATTAGTTGAGACTGGTTCTAAGCAGATCCTAAATAACGCCGATAAGGAAGACGTTGCTTTCTTGGTCGTGGGCGATCCATTTGGTGCCACCACACACACAGATTTAGTTCTCAGAGCTAAACGTGAGGCAATTCCCGTCGAAATTATTCATAATGCGTCCGTTATGAATGCAGTTGGGGCATGTGGCCTACAACTATACAATTTCGGTCAAACCGTTTCCATGGTTTTCTTTACCGATAATTGGAGACCAGACTCATGGTACGACAAGATCTGGGAAAATAGAAAAATTGGCCTTCATACTTTAGTGTTATTGGACATCAAAGTTAAGGAACAAAGCATTGAAAATATGGCCCGTGGCAGACTAATCTACGAACCACCAAGATACATGTCTATCGCTCAATGTTGTGAACAATTATTAGAAATTGAAGAGAAAAGAGGTACAAAGGCATACACTCCTGATACTCCAGCAGTCGCAATTAGTAGATTAGGCTCGAGCTCCCAAAGCTTTAAGTCTGGTACCATAAGTGAGTTAGCCAATTACGATTCAGGAGAGCCACTTCATTCGCTTGTCATCCTCGGCAGACAATGTCATGAATTGGAGCTGGAATACCTGCTAGAGTTTGCCGACGACAAAGAAAAGTTTGGGAAAGATGTGGCAAATGACCAAGAGTACTTCAAACTTGCGGCATGGGTCCCACCCACAGAAGACGACAGCGACGAGTAA","protein_sequence":"MLYLIGLGLSYKSDITVRGLEAIKKCSRVYLEHYTSILMAASQEELESYYGKEIILADRELVETGSKQILNNADKEDVAFLVVGDPFGATTHTDLVLRAKREAIPVEIIHNASVMNAVGACGLQLYNFGQTVSMVFFTDNWRPDSWYDKIWENRKIGLHTLVLLDIKVKEQSIENMARGRLIYEPPRYMSIAQCCEQLLEIEEKRGTKAYTPDTPAVAISRLGSSSQSFKSGTISELANYDSGEPLHSLVILGRQCHELELEYLLEFADDKEKFGKDVANDQEYFKPAAWVPPTEDDSDE"},{"created_at":"2011-05-24T20:23:06.000Z","updated_at":"2011-05-27T14:56:00.000Z","name":"Uroporphyrinogen-III C-methyltransferase","uniprot_id":"P36150","uniprot_name":"SUMT_YEAST","enzyme":true,"transporter":false,"gene_name":"MET1","num_residues":593,"molecular_weight":"66124.70313","theoretical_pi":"6.53","general_function":"Involved in methyltransferase activity","specific_function":"Siroheme synthase involved in methionine biosynthesis","reactions":[{"id":2041,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2312,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.","export":false,"pw_reaction_id":null,"source":null},{"id":2313,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z28294","genbank_protein_id":"486539","gene_card_id":"MET1","chromosome_location":"chromosome 11","locus":"YKR069W","synonyms":["Urogen III methylase","SUMT","Uroporphyrinogen III methylase","UROM"],"enzyme_classes":["2.1.1.107"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" C-methyltransferase activity"},{"category":"Function","description":" uroporphyrin-III C-methyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" heme biosynthetic process"},{"category":"Process","description":" siroheme biosynthetic process"},{"category":"Process","description":" tetrapyrrole metabolic process"},{"category":"Process","description":" porphyrin metabolic process"},{"category":"Process","description":" porphyrin biosynthetic process"}],"pfams":[{"name":"TP_methylase","identifier":"PF00590"}],"pathways":[{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"}],"gene_sequence":"ATGGTACGAGACTTAGTGACATTGCCTTCATCACTGCCCTTGATTACTGCTGGTTTTGCTACTGATCAGGTTCATTTGCTTATTGGTACAGGGTCCACGGACTCAGTAAGCGTTTGTAAGAATAGAATCCACTCCATTTTGAATGCTGGTGGTAATCCCATAGTAGTGAATCCCTCGTCACCAAGCCATACTAAACAATTACAATTGGAATTTGGTAAGTTTGCAAAGTTCGAAATAGTAGAAAGGGAGTTTAGGTTATCTGATTTAACTACTTTGGGGAGAGTTCTGGTATGCAAGGTAGTGGATAGAGTATTCGTAGATCTACCCATAACACAAAGTCGCCTATGCGAGGAGATCTTTTGGCAATGCCAAAAACTGAGAATTCCCATAAATACATTCCACAAACCAGAGTTTTCTACCTTCAATATGATTCCTACGTGGGTCGACCCAAAAGGAAGTGGTTTACAAATCTCAGTTACTACGAATGGGAATGGATACATCTTGGCAAACAGGATAAAAAGAGATATAATATCACACTTACCTCCAAACATATCTGAGGTGGTGATAAACATGGGGTATTTGAAAGACCGTATTATAAACGAAGACCATAAGGCCTTGTTAGAGGAAAAGTACTACCAGACTGACATGTCATTACCTGGATTTGGCTACGGCTTAGATGAGGACGGTTGGGAGAGCCATAAGTTTAATAAGCTAATTCGTGAATTTGAAATGACCAGTAGAGAACAGAGACTTAAGAGAACCAGATGGTTATCTCAGATAATGGAGTATTACCCGATGAACAAGCTGAGTGACATCAAGTTGGAAGATTTCGAGACTTCATCTTCTCCAAATAAAAAGACAAAGCAGGAAACTGTCACAGAGGGTGTAGTACCTCCTACCGATGAAAATATTGAAAACGGTACAAAACAACTACAATTATCGGAAGTGAAAAAAGAGGAGGGACCTAAAAAACTAGGGAAGATTTCTTTAGTCGGAAGTGGTCCAGGCTCGGTATCTATGCTAACGATAGGTGCATTACAAGAAATAAAGTCTGCAGATATAATACTGGCAGATAAACTGGTACCGCAAGCCATTTTAGATTTAATACCTCCAAAAACTGAAACCTTCATAGCCAAAAAATTTCCCGGTAATGCAGAACGAGCACAACAGGAATTACTAGCTAAAGGTTTAGAATCGTTGGATAATGGATTGAAAGTAGTCCGTTTGAAGCAAGGTGATCCGTATATTTTTGGCCGTGGTGGCGAGGAATTTAATTTCTTCAAAGATCACGGATATATTCCTGTGGTTTTACCGGGCATAAGCTCATCCCTAGCTTGTACTGTATTGGCTCAGATACCCGCTACTCAACGTGATATAGCAGACCAAGTGCTCATATGTACTGGGACTGGGAGAAAGGGCGCTCTGCCTATAATTCCTGAATTTGTTGAAAGCAGAACCACCGTCTTTCTAATGGCACTGCATCGCGCCAACGTTCTGATCACGGGATTATTGAAGCATGGCTGGGATGGTGATGTCCCCGCTGCAATTGTCGAGAGAGGATCGTGCCCTGACCAGCGTGTTACTAGAACTCTTCTTAAATGGGTACCAGAAGTCGTGGAGGAGATTGGTTCAAGGCCCCCCGGTGTCTTGGTTGTAGGCAAGGCTGTGAATGCATTGGTTGAAAAAGATCTGATAAATTTTGACGAATCAAGAAAATTTGTCATTGATGAAGGTTTTAGAGAATTTGAGGTTGATGTAGATAGTCTATTTAAGTTATACTAA","protein_sequence":"MVRDLVTLPSSLPLITAGFATDQVHLLIGTGSTDSVSVCKNRIHSILNAGGNPIVVNPSSPSHTKQLQLEFGKFAKFEIVEREFRLSDLTTLGRVLVCKVVDRVFVDLPITQSRLCEEIFWQCQKLRIPINTFHKPEFSTFNMIPTWVDPKGSGLQISVTTNGNGYILANRIKRDIISHLPPNISEVVINMGYLKDRIINEDHKALLEEKYYQTDMSLPGFGYGLDEDGWESHKFNKLIREFEMTSREQRLKRTRWLSQIMEYYPMNKLSDIKLEDFETSSSPNKKTKQETVTEGVVPPTDENIENGTKQLQLSEVKKEEGPKKLGKISLVGSGPGSVSMLTIGALQEIKSADIILADKLVPQAILDLIPPKTETFIAKKFPGNAERAQQELLAKGLESLDNGLKVVRLKQGDPYIFGRGGEEFNFFKDHGYIPVVLPGISSSLACTVLAQIPATQRDIADQVLICTGTGRKGALPIIPEFVESRTTVFLMALHRANVLITGLLKHGWDGDVPAAIVERGSCPDQRVTRTLLKWVPEVVEEIGSRPPGVLVVGKAVNALVEKDLINFDESRKFVIDEGFREFEVDVDSLFKLY"},{"created_at":"2011-05-26T16:35:40.000Z","updated_at":"2011-05-29T05:06:18.000Z","name":"Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial","uniprot_id":"P27680","uniprot_name":"COQ3_YEAST","enzyme":true,"transporter":false,"gene_name":"COQ3","num_residues":312,"molecular_weight":"36330.60156","theoretical_pi":"6.98","general_function":"Involved in methyltransferase activity","specific_function":"Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway","reactions":[{"id":2429,"direction":"\u003e","locations":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","altext":"S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate.","export":false,"pw_reaction_id":null,"source":null},{"id":2430,"direction":"\u003e","locations":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","altext":"S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.","export":false,"pw_reaction_id":null,"source":null},{"id":2431,"direction":"\u003e","locations":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","altext":"S-adenosyl-L-methionine + 2-hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol = S-adenosyl-L-homocysteine + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"M73270","genbank_protein_id":"171392","gene_card_id":"COQ3","chromosome_location":"chromosome 15","locus":"YOL096C","synonyms":["3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase","DHHB methyltransferase","DHHB-MT","DHHB-MTase","Dihydroxyhexaprenylbenzoate methyltransferase"],"enzyme_classes":["2.1.1.114","2.1.1.64"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" C-methyltransferase activity"},{"category":"Function","description":" quinone cofactor methyltransferase activity"},{"category":"Function","description":" 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" oxidoreduction coenzyme metabolic process"},{"category":"Process","description":" ubiquinone metabolic process"},{"category":"Process","description":" ubiquinone biosynthetic process"}],"pfams":[{"name":"Methyltransf_11","identifier":"PF08241"}],"pathways":[{"name":"Ubiquinone and other terpenoid-quinone biosynthesis","kegg_map_id":"00130"}],"gene_sequence":"ATGGGATTCATAATGTTGTTAAGATCTAGATTTTTGAAGGTTATTCATGTGAGGAAACAATTGAGCGCCTGTTCAAGATTTGCAATTCAAACACAAACGAGATGTAAGAGCACAGATGCTTCTGAAGATGAAGTGAAGCATTTCCAGGAGCTAGCCCCTACTTGGTGGGATACAGACGGATCACAAAGAATTCTACACAAAATGAATCTAACTAGGTTAGATTTTGTGCAGAGGACTGTGAGGAACCAGGTTAAAATTCAGAATCCTGAAATATTTGTCCCTGGATTTAATTACAAGGAGTTTCTACCAGAATACGTCTGCGACAATATTCAGCGGGAAATGCAGGAAAGCATAGAGACTAATCTAGATAAGAGGCCAGAAGTGAGCGTCTTGGATGTTGGATGCGGTGGTGGCATTTTGAGTGAATCGCTCGCGAGACTAAAATGGGTGAAGAATGTTCAAGGGATCGATCTGACTCGCGATTGTATCATGGTAGCAAAAGAGCATGCCAAGAAAGACCCCATGCTGGAGGGAAAGATAAATTATGAGTGCAAGGCTCTGGAGGATGTTACTGGACAATTTGATATTATCACCTGTATGGAAATGCTAGAGCACGTGGATATGCCTAGTGAAATTTTAAGGCATTGTTGGTCGAGGTTAAATCCCGAAAAAGGTATACTCTTTTTAAGTACTATAAACAGAGATCTCATCTCATGGTTTACTACAATTTTTATGGGTGAAAACGTCTTGAAGATCGTCCCAAAGGGTACTCATCATTTGAGCAAATACATAAACTCAAAGGAAATCCTTGCCTGGTTCAATGACAACTACAGTGGCCAATTTCGCTTGTTGGATCTCAAGGGGACCATGTACCTCCCATATCAAGGGTGGGTTGAGCACGATTGTTCCGATGTCGGTAATTATTTTATGGCTATTCAGAGACTGAATTGA","protein_sequence":"MLLRSRFLKVIHVRKQLSACSRFAIQTQTRCKSTDASEDEVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVRNQVKIQNPEIFVPGFNYKEFLPEYVCDNIQREMQESIETNLDKRPEVSVLDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAKKDPMLEGKINYECKALEDVTGQFDIITCMEMLEHVDMPSEILRHCWSRLNPEKGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHHLSKYINSKEILAWFNDNYSGQFRLLDLKGTMYLPYQGWVEHDCSDVGNYFMAIQRLN"},{"created_at":"2011-05-26T17:19:36.000Z","updated_at":"2011-07-22T17:54:19.000Z","name":"Biotin synthase, mitochondrial","uniprot_id":"P32451","uniprot_name":"BIOB_YEAST","enzyme":true,"transporter":false,"gene_name":"BIO2","num_residues":375,"molecular_weight":"41883.80078","theoretical_pi":"8.66","general_function":"Involved in catalytic activity","specific_function":"Dethiobiotin + sulfur + 2 S-adenosyl-L- methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine","reactions":[{"id":1347,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2472,"direction":"\u003e","locations":"Mitochondrion","altext":"Dethiobiotin + sulfur + 2 S-adenosyl-L-methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine.","export":false,"pw_reaction_id":null,"source":null},{"id":3756,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006280","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"Z73071","genbank_protein_id":"1323523","gene_card_id":"BIO2","chromosome_location":"chromosome 7","locus":"YGR286C","synonyms":[],"enzyme_classes":["2.8.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" transferase activity, transferring sulfur-containing groups"},{"category":"Function","description":" sulfurtransferase activity"},{"category":"Function","description":" biotin synthase activity"},{"category":"Process","description":" biotin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" vitamin metabolic process"},{"category":"Process","description":" water-soluble vitamin metabolic process"},{"category":"Process","description":" biotin metabolic process"}],"pfams":[{"name":"Radical_SAM","identifier":"PF04055"},{"name":"BATS","identifier":"PF06968"}],"pathways":[{"name":"Biotin metabolism","kegg_map_id":"00780"},{"name":"Biotin Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGATGTCTACTATCTACCGTCATTTATCTACCGCTAGACCGGCTTTAACTAAATACGCAACCAATGCCGCAGTTAAATCGACAACTGCATCCTCAGAAGCTAGTACTCTGGGTGCTCTACAATATGCATTGTCTTTAGATGAACCAAGTCATTCGTGGACAAAATCGCAATTAAAAGAAATTTATCATACCCCACTGCTCGAACTTACTCATGCAGCACAATTGCAGCACAGAAAGTGGCACGATCCAACCAAAGTGCAATTGTGCACATTGATGAACATCAAATCTGGTGGTTGTTCTGAGGACTGTAAGTATTGTGCGCAGTCTTCGAGAAACGATACCGGTCTAAAGGCTGAGAAAATGGTTAAAGTGGATGAAGTGATTAAAGAGGCAGAAGAGGCCAAAAGAAACGGATCTACTAGATTCTGCCTAGGTGCTGCATGGAGAGACATGAAAGGTCGTAAATCAGCCATGAAAAGAATTCAGGAAATGGTGACCAAAGTGAATGATATGGGGCTAGAAACGTGTGTTACTTTAGGTATGGTTGATCAAGATCAAGCAAAGCAATTGAAAGATGCAGGTTTGACTGCATACAACCATAACATCGACACTTCCAGAGAACACTATAGTAAGGTCATCACCACGAGAACCTACGACGACAGGTTACAGACCATCAAGAATGTCCAAGAATCTGGAATAAAAGCCTGTACCGGTGGTATTTTGGGTCTCGGTGAAAGCGAAGACGACCATATAGGATTCATCTACACATTATCCAATATGTCTCCTCATCCTGAGTCCCTACCAATTAATAGACTAGTTGCTATCAAAGGGACTCCAATGGCTGAGGAACTTGCCGATCCAAAGAGTAAAAAGTTGCAATTCGACGAAATTTTGAGAACCATTGCCACAGCGAGAATAGTTATGCCAAAGGCCATTATAAGACTTGCCGCTGGTCGTTATACAATGAAAGAAACAGAGCAATTTGTCTGTTTCATGGCAGGTTGTAACAGTATCTTCACCGGTAAGAAAATGCTGACGACAATGTGTAACGGTTGGGACGAAGACAAGGCAATGTTGGCTAAATGGGGATTGCAACCTATGGAGGCATTTAAGTACGACAGATCTTGA","protein_sequence":"MMSTIYRHLSTARPALTKYATNAAVKSTTASSEASTLGALQYALSLDEPSHSWTKSQLKEIYHTPLLELTHAAQLQHRKWHDPTKVQLCTLMNIKSGGCSEDCKYCAQSSRNDTGLKAEKMVKVDEVIKEAEEAKRNGSTRFCLGAAWRDMKGRKSAMKRIQEMVTKVNDMGLETCVTLGMVDQDQAKQLKDAGLTAYNHNIDTSREHYSKVITTRTYDDRLQTIKNVQESGIKACTGGILGLGESEDDHIGFIYTLSNMSPHPESLPINRLVAIKGTPMAEELADPKSKKLQFDEILRTIATARIVMPKAIIRLAAGRYTMKETEQFVCFMAGCNSIFTGKKMLTTMCNGWDEDKAMLAKWGLQPMEAFKYDRS"},{"created_at":"2011-05-26T19:26:29.000Z","updated_at":"2011-07-22T17:54:00.000Z","name":"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase","uniprot_id":"P50277","uniprot_name":"BIOA_YEAST","enzyme":true,"transporter":false,"gene_name":"BIO3","num_residues":480,"molecular_weight":"53708.39844","theoretical_pi":"6.41","general_function":"Involved in transaminase activity","specific_function":"Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor","reactions":[{"id":1274,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2566,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate.","export":false,"pw_reaction_id":null,"source":null},{"id":3754,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006278","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AB200248","genbank_protein_id":"67772574","gene_card_id":"BIO3","chromosome_location":"chromosome 14","locus":"YNR058W","synonyms":["7,8-diamino-pelargonic acid aminotransferase","DAPA AT","DAPA aminotransferase","Diaminopelargonic acid synthase"],"enzyme_classes":["2.6.1.62"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" adenosylmethionine-8-amino-7-oxononanoate transaminase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" vitamin metabolic process"},{"category":"Process","description":" water-soluble vitamin metabolic process"},{"category":"Process","description":" biotin metabolic process"},{"category":"Process","description":" biotin biosynthetic process"}],"pfams":[{"name":"Aminotran_3","identifier":"PF00202"}],"pathways":[{"name":"Biotin metabolism","kegg_map_id":"00780"},{"name":"Biotin Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTCCCAAGAAATTTCATATACACCAGATGTCGCGGAACTGCTAGACTTTGATAAAAAACATATTTGGCATCCTTATACGTCATTGAGTTCACCATTGAACGTTTATCCGGTAAAGAGTGCTCACGGATGCAAGCTGGTGTTGGATACCGACTCACCAGTGGACGTCGAGGTGATCGACGCCATGTCGTCGTGGTGGTGTGTTATTCACGGGTACAATAATCCAGAATTAAATGAGGCCCTTACCAAGCAGATGTTAAAGTTTTCTCACGTCCTTCTTGGTGGATTCACCCATAAAGGAGCTGTGAATCTAGTCCAAAAACTTTTAAAAGTGATTGATGAACCCTCTTTGCAGTACTGTTTCCTCGCAGATTCTGGCTCAGTAGCAGTGGAAGTAGCTTTGAAGATGGCTTTACAATCAAACATGTCAGGGGAAGCTACTAAAAATAGAACAAAATTTTTGACAATCAAGAACGGGTATCATGGTGATACATTTGGCGCTATGAGTGTTTGTGATCCTGAGAATTCTATGCATCATATCTACAACGATCGACTCAGTGAGAACATCTTCGCCCAAGCTCCCTCTATTGTCGATGGTCTTCCAACCAGCCAGAACGGTTTCGAGGACCATTGGAATGCAGAAGAAGTTACCGATCTCAAGAAGCAATTTGAATTGCATAGTGATGAGATCTGTGCTGTGATTTTGGAGCCTATCTTACAGGGTGCAGGAGGTTTGCGACCATACCATCCACAGTTCCTAATTGAAGTTCAGAAACTATGTAACCAATACGACGTTTTATTCATCATGGACGAGATTGCTACGGGATTTGGTAGAACAGGTGAGATTTTCGCATTCAAGCACTGTCAAAAATACCAGGACCAACGTGGCATCAGTCCTTCCGATCAGATCAAAGTTGTTCCTGACATATTGTGCGTTGGGAAGGGCTTAACCAGTGGATATATGACTATGAGTGCAGTGGTAGTCAACGACAAAGTTGCTTCCAGAATCTCTTCTCCAAATAGCCCTACTGGTGGCTGCTTCATGCATGGCCCCACCTTCATGGGCAATGCCCTGGCATGCAGTGTGGCAGAAAAGTCTATGGATATACTACTGCGTGGCGAGTGGAGAAAACAAGTGTCTGCAATTGAAGACCAAATTTATAGAGAACTATACCAGTACATCAAGAACCCAGATAATGGGCTCATTGGAACTGTTGTTAAGCGTGTGTCAGTTATTGGAGCTGTAGGTATCGTAGAGCTATACAAGAAGACAGATCCCGAGTGGTTCCAGAAAAAGTTTATATCCAAGGGAGTACATATCCGACCTTTCAACTGCCTGTGTTACATTATGCCACCATATGTGATCACGACAGAGGAATTGACGAAGGTTAATCAAGTCTTGATTGAAGTATTACATGAGTGGAAATCCCACATAAACCAATGA","protein_sequence":"MSQEISYTPDVAELLDFDKKHIWHPYTSLSSPLNVYPVKSAHGCKLVLDTDSPVDVEVIDAMSSWWCVIHGYNNPELNEALTKQMLKFSHVLLGGFTHKGAVNLVQKLLKVIDEPSLQYCFLADSGSVAVEVALKMALQSNMSGEATKNRTKFLTIKNGYHGDTFGAMSVCDPENSMHHIYNDRLSENIFAQAPSIVDGLPTSQNGFEDHWNAEEVTDLKKQFELHSDKICAVILEPILQGAGGLRPYHPQFLIEVQKLCNQYDVLFIMDEIATGFGRTGEIFAFKHCQKYQDQHGISPSDQIKVVPDILCVGKGLTSGYMTMSAVVVNDKVASRISSPNSPTGGCFMHGPTFMGNALACSVAEKSMDILLRGEWRKQVSAIENQIYRELYQYIKNPDNGLIGTVVKRVSVIGAVGIVELYKKTDPEWFQKKFISKGVHIRPFNCLCYIMPPYVITTEELTKVNQVLIEVLHEWKSHINQ"},{"created_at":"2011-05-26T19:35:43.000Z","updated_at":"2011-05-27T15:01:07.000Z","name":"S-adenosylmethionine synthase 1","uniprot_id":"P10659","uniprot_name":"METK1_YEAST","enzyme":true,"transporter":false,"gene_name":"SAM1","num_residues":382,"molecular_weight":"41818.0","theoretical_pi":"4.83","general_function":"Involved in methionine adenosyltransferase activity","specific_function":"Catalyzes the formation of S-adenosylmethionine from methionine and ATP","reactions":[{"id":1728,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2580,"direction":"\u003e","locations":"","altext":"ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.","export":false,"pw_reaction_id":null,"source":null},{"id":3761,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006285","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"J03477","genbank_protein_id":"172534","gene_card_id":"SAM1","chromosome_location":"chromosome 12","locus":"YLR180W","synonyms":["AdoMet synthase 1","Methionine adenosyltransferase 1","MAT 1"],"enzyme_classes":["2.5.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" methionine adenosyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" one-carbon metabolic process"}],"pfams":[{"name":"S-AdoMet_synt_C","identifier":"PF02773"},{"name":"S-AdoMet_synt_M","identifier":"PF02772"},{"name":"S-AdoMet_synt_N","identifier":"PF00438"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGGCCGGTACATTTTTATTCACTTCTGAATCCGTTGGTGAAGGTCACCCAGATAAGATCTGTGACCAAGTTTCCGACGCCATCTTGGACGCTTGTTTAGCCGAGGACCCTCACTCCAAAGTTGCGTGTGAAACCGCGGCAAAGACTGGTATGATTATGGTCTTTGGTGAAATTACTACCAAGGCACAGTTGGATTACCAAAAAATCGTCAGAGACACCATCAAGAAGATTGGTTACGATGATTCCGCCAAGGGTTTCGACTATAAGACCTGTAACGTCCTTGTCGCCATTGAGCAACAATCTCCAGATATCGCCCAAGGTGTCCACGAGGAGAAGGATTTGGAAGACATCGGTGCCGGTGACCAAGGTATCATGTTTGGTTACGCCACAGATGAAACTCCAGAGGGTTTGCCTTTGACTATTCTTTTGGCTCATAAACTAAACATGGCCATGGCTGACGCGAGAAGAGATGGCTCTTTAGCGTGGTTGAGACCAGACACCAAGACTCAAGTCACCGTCGAATACAAGGATGACCACGGTAGATGGGTTCCACAAAGAATCGACACCGTCGTCGTCTCCGCTCAACATGCTGACGAAATCACGACCGAGGACTTAAGAGCGCAACTAAAGTCCGAGATCATTGAAAAAGTCATCCCAAGAGACATGTTGGACGAAAACACCAAATACTTTATCCAACCTTCCGGTAGATTCGTCATCGGTGGTCCTCAAGGTGACACTGGTTTGACCGGTAGAAAGATCATCGTCGACGCTTACGGTGGTGCCTCATCCGTCGGTGGTGGTGCCTTCTCCGGTAAGGACTACTCTAAGGTTGATCGTTCTGCCGCTTATGCCGCTAGATGGGTTGCCAAGTCCCTAGTTGCCGCTGGTTTATGTAAGAGAGTTCAAGTTCAATTTTCTTATGCCATCGGTATTGCGGAACCATTGTCCTTGCACGTTGACACCTATGGTACTGCGACCAAGTCTGACGAAGAAATTATCGACATTATCAGCAAGAACTTTGACTTGAGACCTGGTGTATTGGTCAAGGAGTTGGACTTAGCTAGACCATTCTACTTGCCAACCGCTTCTTATGGCCATTTCACAAACCAAGAATACCCATGGGAAAAGCCTAAGACTTTGAAGTTCTAA","protein_sequence":"MAGTFLFTSESVGEGHPDKICDQVSDAILDACLAEDPHSKVACETAAKTGMIMVFGEITTKAQLDYQKIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGVHEEKDLEDIGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLAWLRPDTKTQVTVEYKDDHGRWVPQRIDTVVVSAQHADEITTEDLRAQLKSEIIEKVIPRDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDEEIIDIISKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYPWEKPKTLKF"},{"created_at":"2011-05-27T02:12:57.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Lipoyl synthase, mitochondrial","uniprot_id":"P32875","uniprot_name":"LIPA_YEAST","enzyme":true,"transporter":false,"gene_name":"LIP5","num_residues":414,"molecular_weight":"46246.80078","theoretical_pi":"10.05","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (Probable)","reactions":[{"id":2662,"direction":"\u003e","locations":"Mitochondrion","altext":"Protein N(6)-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14866,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007053","source":"Smpdb"},{"id":14867,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007054","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY558046","genbank_protein_id":"45269982","gene_card_id":"LIP5","chromosome_location":"chromosome 15","locus":"YOR196C","synonyms":["Lipoate synthase","LS","Lip-syn","Lipoic acid synthase"],"enzyme_classes":["2.8.1.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" 4 iron, 4 sulfur cluster binding"},{"category":"Function","description":" transferase activity, transferring sulfur-containing groups"},{"category":"Function","description":" sulfurtransferase activity"},{"category":"Function","description":" lipoate synthase activity"},{"category":"Process","description":" lipoate biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" lipoic acid metabolic process"},{"category":"Process","description":" lipoic acid biosynthetic process"}],"pfams":[{"name":"Radical_SAM","identifier":"PF04055"}],"pathways":[{"name":"Lipoic acid metabolism","kegg_map_id":"00785"}],"gene_sequence":"ATGTATAGACGATCTGTTGGAGTACTATTTGTTGGGAGAAATACAAGATGGATTTCGTCCACTATTAGGTGTGGAACGAGCGCAACTCGGCCAATAAGATCCAATGCATTGAATACTGATTCAGATAACGCTAGCGTTAGGGTACCAGTTGGAAATTCAACTGAGGTTGAAAATGCAACCAGTCAGTTAACAGGGACTTCGGGAAAAAGACGCAAGGGGAACAGAAAAAGAATTACAGAGTTCAAAGATGCTCTTAATTTGGGTCCATCTTTTGCAGATTTTGTTTCAGGTAAAGCTTCGAAAATGATCTTGGACCCTCTGGAGAAGGCAAGGCAAAATACAGAGGAAGCTAAAAAACTACCTCGTTGGCTTAAGGTTCCTATTCCTAAGGGTACCAATTACCATAAATTGAAAGGCGACGTAAAAGAATTAGGCCTGAGTACTGTTTGTGAGGAGGCAAGATGTCCCAATATTGGTGAATGTTGGGGAGGCAAAGATAAATCTAAGGCAACGGCAACAATTATGCTGCTTGGTGATACTTGCACTCGTGGATGTAGGTTTTGTTCTGTGAAGACCAATAGAACGCCTAGTAAGCCGGACCCAATGGAGCCCGAAAATACTGCCGAAGCTATCAAAAGATGGGGGTTGGGTTATGTTGTTTTAACTACCGTTGATAGGGACGATTTAGTCGATGGTGGTGCTAATCACCTGGCCGAGACGGTTCGCAAAATCAAACAGAAGGCACCAAATACTCTTGTAGAGACTCTTTCTGGTGATTTCAGAGGTGATTTGAAGATGGTGGACATTATGGCACAATGTGGGCTTGATGTTTACGCACATAATTTGGAAACAGTTGAATCACTAACACCACATGTCAGAGACAGAAGAGCTACTTATAGACAGTCTTTGAGTGTTTTAGAAAGGGCAAAAGCTACGGTTCCGTCACTGATTACTAAAACATCAATAATGCTGGGTCTAGGAGAAACTGATGAGCAAATTACTCAAACTTTGAAGGATTTGCGCAATATTCAATGTGATGTTGTTACATTTGGTCAATATATGAGGCCAACCAAGAGACATATGAAAGTCGTAGAATATGTGAAACCCGAAAAGTTTGACTACTGGAAAGAGAGAGCTTTAGAGATGGGATTCTTGTATTGTGCATCTGGACCCCTAGTAAGATCGTCATATAAGGCTGGTGAAGCATTTATTGAGAACGTTTTGAAGAAAAGAAACATGAAATAA","protein_sequence":"MYRRSVGVLFVGRNTRWISSTIRCGTSATRPIRSNALNTDSDNASVRVPVGNSTEVENATSQLTGTSGKRRKGNRKRITEFKDALNLGPSFADFVSGKASKMILDPLEKARQNTEEAKKLPRWLKVPIPKGTNYHKLKGDVKELGLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRTPSKPDPMEPENTAEAIKRWGLGYVVLTTVDRDDLVDGGANHLAETVRKIKQKAPNTLVETLSGDFRGDLKMVDIMAQCGLDVYAHNLETVESLTPHVRDRRATYRQSLSVLERAKATVPSLITKTSIMLGLGETDEQITQTLKDLRNIQCDVVTFGQYMRPTKRHMKVVEYVKPEKFDYWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRNMK"},{"created_at":"2011-05-27T02:13:35.000Z","updated_at":"2011-07-22T17:53:47.000Z","name":"Trans-aconitate 3-methyltransferase","uniprot_id":"P32643","uniprot_name":"TMT1_YEAST","enzyme":true,"transporter":false,"gene_name":"TMT1","num_residues":299,"molecular_weight":"34768.0","theoretical_pi":"6.18","general_function":"Involved in methyltransferase activity","specific_function":"Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation","reactions":[{"id":1181,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2014,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2663,"direction":"\u003e","locations":"Cytoplasm","altext":"S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U18922","genbank_protein_id":"603416","gene_card_id":"TMT1","chromosome_location":"chromosome 5","locus":"YER175C","synonyms":[],"enzyme_classes":["2.1.1.145"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Methyltransf_11","identifier":"PF08241"}],"pathways":[],"gene_sequence":"ATGTCTACCTTTTCTGCTTCTGATTTCAACTCAGAAAGATATTCATCTTCAAGACCTTCTTATCCCTCCGATTTTTACAAGATGATTGATGAATACCACGACGGAGAAAGGAAATTACTCGTAGATGTTGGCTGTGGACCAGGTACTGCCACTTTACAAATGGCTCAGGAGTTAAAACCATTCGAACAAATTATCGGAAGCGATCTCTCCGCTACCATGATTAAGACTGCAGAAGTAATAAAGGAAGGAAGTCCTGATACATACAAAAACGTTTCATTTAAGATTTCTTCAAGTGATGATTTTAAATTCCTAGGCGCGGATTCAGTAGACAAACAGAAAATTGATATGATTACCGCAGTAGAATGTGCTCATTGGTTCGATTTCGAAAAATTTCAGCGATCTGCTTATGCCAATTTGAGAAAAGATGGTACTATCGCTATTTGGGGTTATGCGGACCCAATTTTCCCGGACTACCCTGAATTTGATGATCTGATGATTGAAGTTCCTTACGGGAAGCAAGGACTGGGACCCTATTGGGAACAACCGGGGAGATCTCGCCTTCGTAATATGCTGAAAGACTCTCACTTAGACCCAGAACTTTTCCATGATATACAAGTTTCATATTTTTGTGCAGAAGATGTGAGAGACAAAGTAAAACTCCACCAGCATACAAAGAAGCCATTGCTAATCAGAAAGCAGGTCACCCTAGTGGAGTTTGCAGATTATGTCAGAACCTGGAGCGCTTACCATCAGTGGAAGCAGGATCCAAAGAACAAAGATAAAGAAGATGTAGCAGATTGGTTTATTAAAGAGTCACTAAGGAGGAGGCCGGAACTTTCCACCAACACCAAAATTGAAGTTGTTTGGAATACTTTTTACAAACTTGGCAAAAGGGTCTGA","protein_sequence":"MSTFSASDFNSERYSSSRPSYPSDFYKMIDEYHDGERKLLVDVGCGPGTATLQMAQELKPFEQIIGSDLSATMIKTAEVIKEGSPDTYKNVSFKISSSDDFKFLGADSVDKQKIDMITAVECAHWFDFEKFQRSAYANLRKDGTIAIWGYADPIFPDYPEFDDLMIEVPYGKQGLGPYWEQPGRSRLRNMLKDSHLDPELFHDIQVSYFCAEDVRDKVKLHQHTKKPLLIRKQVTLVEFADYVRTWSAYHQWKQDPKNKDKEDVADWFIKESLRRRPELSTNTKIEVVWNTFYKLGKRV"},{"created_at":"2011-05-27T02:19:33.000Z","updated_at":"2011-07-22T17:54:00.000Z","name":"S-adenosylmethionine decarboxylase proenzyme","uniprot_id":"P21182","uniprot_name":"DCAM_YEAST","enzyme":true,"transporter":false,"gene_name":"SPE2","num_residues":396,"molecular_weight":"46232.0","theoretical_pi":"5.32","general_function":"Involved in adenosylmethionine decarboxylase activity","specific_function":"S-adenosylmethionine decarboxylase is essential for normal growth, sporulation, maintenance of ds-RNA virus, biosynthesis of spermine and spermidine","reactions":[{"id":1273,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2671,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3760,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006284","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M38434","genbank_protein_id":"171055","gene_card_id":"SPE2","chromosome_location":"chromosome 15","locus":"YOL052C","synonyms":["AdoMetDC","SAMDC","S-adenosylmethionine decarboxylase alpha chain","S-adenosylmethionine decarboxylase beta chain"],"enzyme_classes":["4.1.1.50"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" adenosylmethionine decarboxylase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" spermidine biosynthetic process"},{"category":"Process","description":" polyamine metabolic process"},{"category":"Process","description":" polyamine biosynthetic process"},{"category":"Process","description":" spermine biosynthetic process"}],"pfams":[{"name":"SAM_decarbox","identifier":"PF01536"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"}],"gene_sequence":"ATGACTGTCACCATAAAAGAATTGACTAACCACAACTACATTGACCACGAACTATCAGCCACTTTAGACTCAACGGATGCGTTCGAGGGTCCCGAGAAGTTGCTGGAAATCTGGTTCTTCCCTCACAAGAAGTCCATCACGACCGAAAAGACATTAAGAAATATTGGCATGGATAGATGGATCGAGATTTTGAAATTAGTGAAATGCGAAGTTCTTTCCATGAAGAAGACTAAAGAACTGGATGCCTTTTTGTTGAGTGAGTCTTCCCTCTTCGTCTTCGATCACAAATTGACGATGAAGACGTGCGGTACTACAACCACATTGTTCTGTCTCGAAAAGCTTTTCCAGATCGTTGAGCAAGAGTTATCGTGGGCTTTCCGCACAACACAAGGGGGCAAGTACAAACCATTTAAAGTGTTTTATTCTAGACGATGTTTCCTTTTCCCCTGTAAGCAAGCCGCTATCCATCAAAACTGGGCTGACGAAGTCGACTATTTGAACAAATTTTTCGACAATGGTAAAAGTTATTCCGTGGGAAGAAATGACAAGAGCAACCACTGGAACCTGTACGTCACCGAGACGGACCGCTCCACACCTAAGGGAAAGGAGTACATCGAGGATGACGACGAAACTTTCGAAGTACTGATGACGGAGCTGGACCCAGAATGCGCTAGTAAGTTTGTTTGCGGGCCTGAGGCATCCACAACCGCTCTCGTGGAGCCAAACGAAGATAAGGGCCACAACCTCGGCTACCAAATGACTAAAAATACAAGGCTTGACGAAATATATGTCAACTCGGCCCAAGACTCCGATTTATCATTTCACCACGATGCATTTGCGTTCACGCCATGTGGATACTCATCCAATATGATTCTCGCTGAAAAATACTATTACACCCTGCACGTGACTCCGGAAAAGGGTTGGTCTTACGCCTCTTTCGAAAGTAACATACCCGTATTTGACATTTCCCAAGGGAAGCAAGACAACTTGGACGTTCTTCTACATATTCTGAACGTTTTTCAACCAAGAGAGTTCTCGATGACCTTTTTTACCAAAAATTATCAGAACCAATCCTTCCAAAAACTACTAAGCATCAACGAGTCACTGCCCGACTACATCAAGTTAGACAAAATTGTTTATGATCTGGACGACTACCACCTTTTCTATATGAAATTGCAGAAGAAAATATGA","protein_sequence":"MTVTIKELTNHNYIDHELSATLDSTDAFEGPEKLLEIWFFPHKKSITTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTCGTTTTLFCLEKLFQIVEQELSWAFRTTQGGKYKPFKVFYSRRCFLFPCKQAAIHQNWADEVDYLNKFFDNGKSYSVGRNDKSNHWNLYVTETDRSTPKGKEYIEDDDETFEVLMTELDPECASKFVCGPEASTTALVEPNEDKGHNLGYQMTKNTRLDEIYVNSAQDSDLSFHHDAFAFTPCGYSSNMILAEKYYYTLHVTPEKGWSYASFESNIPVFDISQGKQDNLDVLLHILNVFQPREFSMTFFTKNYQNQSFQKLLSINESLPDYIKLDKIVYDLDDYHLFYMKLQKKI"},{"created_at":"2011-05-27T03:11:11.000Z","updated_at":"2011-05-29T05:06:37.000Z","name":"Ubiquinone biosynthesis methyltransferase COQ5, mitochondrial","uniprot_id":"P49017","uniprot_name":"COQ5_YEAST","enzyme":true,"transporter":false,"gene_name":"COQ5","num_residues":307,"molecular_weight":"34684.19922","theoretical_pi":"6.52","general_function":"Involved in methyltransferase activity","specific_function":"Converts DDMQH2 into DMQH2","reactions":[{"id":2709,"direction":"\u003e","locations":"Mitochondrion","altext":"S-adenosyl-L-methionine + 2-polyprenyl-6-methoxy-1,4-benzoquinol = S-adenosyl-L-homocysteine + 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY693194","genbank_protein_id":"51013839","gene_card_id":"COQ5","chromosome_location":"chromosome 13","locus":"YML110C","synonyms":[],"enzyme_classes":["2.1.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Ubie_methyltran","identifier":"PF01209"}],"pathways":[],"gene_sequence":"ATGTTGATTTCTTCACGGATCGTTCGAAGCTCGCTGGTAAATGTCCCGCTAAGATTATCTAGGTGTTTTACGCAAGCTCACAGAGCATGCAAAGAAGAAGAAGTTAATAGTCCTTTATCATCCGCAGCTGAACAGCCAGAGCAGAAGTATACGCATTTTGGTTCGAAGACTGTATTGAAGTCTACCAAGCAGAAGTTAGTTGGTGATGTCTTTTCTTCCGTGGCCAATCGGTATGACTTGATGAATGATGTTATGTCATTAGGAATTCATAGATTGTGGAAGGACCATTTTATCAATAAACTAGATGCGGGAAAAAGGCCAAACTCTACGACTCCTTTGAACTTCATAGATGTGGCTGGGGGATCCGGTGATATTGCTTTCGGATTACTAGACCATGCTGAGTCGAAATTTGGTGACACTGAGTCTACAATGGATATTGTAGATATCAACCCTGACATGCTTAAAGAAGGTGAGAAGAGAGCCATGGAGCAAGGAAAATATTTCAAGGATCCTCGTGTGAGATTTTTGGTTTCTAATGGTGAGAAACTAGAGGAGATTGATTCTGATTCCAAGGACATCTACACAGTCTCCTTCGGTATCAGAAATTTCACCGATATTCAAAAGGGTTTAAACACTGCTTATAGAGTTTTGAAACCGGGCGGTATTTTTTATTGTCTAGAATTTTCCAAAATTGAGAATCCCCTAATGGACTTTGCTTACCAACAGTGGGCTAAGGTCCTACCTGTAATGGGCTCGATGATTGCTAATGACTACGACTCTTACCAGTATTTGGTGGAGTCTATCGAAAGATTTCCTGACCAAGAAACGTTCAAATCCATGATTGAGAAGGCAGGATTCAAATCTGCTGGCTACGAAAGTTTAACTTTTGGTATATGTGCCATCCATTGGGGCATTAAAGTTTAA","protein_sequence":"MLISSRIVRSSLVNVPLRLSRCFTQAHRACKEEEVNSPLSSAAEQPEQKYTHFGSKTVLKSTKQKLVGDVFSSVANRYDLMNDVMSLGIHRLWKDHFINKLDAGKRPNSTTPLNFIDVAGGSGDIAFGLLDHAESKFGDTESTMDIVDINPDMLKEGEKRAMEQGKYFKDPRVRFLVSNGEKLEEIDSDSKDIYTVSFGIRNFTDIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIANDYDSYQYLVESIERFPDQETFKSMIEKAGFKSAGYESLTFGICAIHWGIKV"},{"created_at":"2011-05-27T03:31:10.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"tRNA (uracil-O(2)-)-methyltransferase","uniprot_id":"Q02648","uniprot_name":"TRM44_YEAST","enzyme":true,"transporter":false,"gene_name":"TRM44","num_residues":567,"molecular_weight":"64854.60156","theoretical_pi":"8.79","general_function":"Involved in methyltransferase activity","specific_function":"tRNA (uracil-O(2)-)-methyltransferase, which catalyzes the formation of O(2)-methyluracil at position 44 (m2U44) in tRNA(Ser)","reactions":[{"id":2725,"direction":"\u003e","locations":"Cytoplasm","altext":"S-adenosyl-L-methionine + uridine(44) in tRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine(44) in tRNA.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U36624","genbank_protein_id":"1039447","gene_card_id":"TRM44","chromosome_location":"chromosome 16","locus":"YPL030W","synonyms":["tRNA(M-2-U44)-methyltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"AdoMet_MTase","identifier":"PF07757"}],"pathways":[],"gene_sequence":"ATGACTGGCGACGGTAGTGCACATATTTCTAAAAACAATCAAAATCAACACAAAGATCGCTTCAAGTTTATTGTGAATGATAAAAGTATTCTAGGACCTCAATGGTTAAGCCTTTACCAAACGGATGGGAAAGTAACATTCGCAAAGTCCCACTTCGAGCAAGCAATGATGAACGTTATTAGAGAACCAAATATTAACTCTACTGTCATATTAAGAGCGGATATTTTGAAAGAGATCAATCATGCTGCAGAAGCTGGGTCTGAGCCAAAATTTGACGAGTCCGTATTAAAAAAGTTTGAGATCGATAATGGTAATGAAAGCGGTGAAGAAGATGTCAAGAAGATAAATATTGAAGATTTAAACATAAGGTCGTGTGAAACATCTGAGAGTTTAAAATTGTCACCCGTTCATGAATTTGTAAGAAGGATCATTCCTAGGAATTTTTACAAAGATGCTATCATAAACCAAACATGTTTAATCCTAAATAGCAAAGACCCTAATTTTCAGGAGACCTCATTGATTGTATATACGCCGCACATTAACTCTGAGAAAGACTGTCCGTTTTATATTCCAAGAACGCAAAGTGTAGGCATTTTGTTACACCAGTCAGTTCTTTCTGTACACTACATTCCCTTCCCCGAGGATAAAACTGCCTTTACAGATGAATCTGAGCGTGTTGTAAGAACCGCTTATAGGTTATTACAAACTGCTAACAAACACTCAAAGGGTGTGATGCAGGGTTATGAAAAGAGGGTCAATCACGATCAAGTGGTAAATAAAGTCAATTTTCAGAACACATACATTGTTTTGAAGAAAAAATACTCCAAGTTCCTGGTGGAGAATTGGGCAGAGTCTACAGACCCAAAAAAACATGTTTTTGAAGACATAGCCATTGCCGCTTTCCTGATTGAATTATGGATTAAAGTGTACGGTCCAGACTTCCGTTCAAAAATGCAATTTAGAGATTTGGGATGCGGCAATGGTGCTCTTTGTTATATTTTACTGAGTGAAAGTATTAAAGGTCTCGGCATAGATGCAAGGAAGCGCAAATCGTGGTCTATCTACCCGCCTGAAGTGCAATCATCGTTAAAGGAGCAAGTTATAATACCTTCTATCCTTTTAAGACCCCATCCTGCTTTGAAAAGACAAGTACCTCATTTGGAACACAATGGGAGATTTTTCCCAGTCAAGGTGACGCACGAAGTGATTGCCCCCGCAACCGTCGTGTATTCAAGTGAGGACTTACTAAAATCTCCGCAGGTCAATACAGCAGAGTTCCCACCAGATACTTTTATTATAGGTAACCACTCAGATGAGTTGACTTGCTGGATCCCATTACTAGGTCATCCTTATATGGTTATACCTTGTTGCTCTCATAATTTTTCTGGCCAGAGAGTTCGTTTTAACGTAAGGAAACGTTCGCCTAGGTCAAATGAAATCAAAAACCAGAATAACAGTAAGAGCACCTACTCTGGTTTGGTTGATCACGTTGAATATATTTCATCTCGTGTAGGCTGGAAAGTAGAGAAAGAGATGTTAAGGATACCAAGCACAAGAAATGCAGCCATCATAGGTGTAGAAAATGCAACCTTAAAGCATTTTCCAACGCAAGCAGTGTACGATATGATTTGGGAAGACGGTGGAGCTGAAGGGTGGATTCAGAACACAATGTCCTTATTGAAAAGAAACCCAAGAAACCATTAA","protein_sequence":"MTGDGSAHISKNNQNQHKDRFKFIVNDKSILGPQWLSLYQTDGKVTFAKSHFEQAMMNVIREPNINSTVILRADILKEINHAAEAGSEPKFDESVLKKFEIDNGNESGEEDVKKINIEDLNIRSCETSESLKLSPVHEFVRRIIPRNFYKDAIINQTCLILNSKDPNFQETSLIVYTPHINSEKDCPFYIPRTQSVGILLHQSVLSVHYIPFPEDKTAFTDESERVVRTAYRLLQTANKHSKGVMQGYEKRVNHDQVVNKVNFQNTYIVLKKKYSKFLVENWAESTDPKKHVFEDIAIAAFLIELWIKVYGPDFRSKMQFRDLGCGNGALCYILLSESIKGLGIDARKRKSWSIYPPEVQSSLKEQVIIPSILLRPHPALKRQVPHLEHNGRFFPVKVTHEVIAPATVVYSSEDLLKSPQVNTAEFPPDTFIIGNHSDELTCWIPLLGHPYMVIPCCSHNFSGQRVRFNVRKRSPRSNEIKNQNNSKSTYSGLVDHVEYISSRVGWKVEKEMLRIPSTRNAAIIGVENATLKHFPTQAVYDMIWEDGGAEGWIQNTMSLLKRNPRNH"},{"created_at":"2011-05-27T03:31:26.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Cytochrome c lysine N-methyltransferase 1","uniprot_id":"P38818","uniprot_name":"CTM1_YEAST","enzyme":true,"transporter":false,"gene_name":"CTM1","num_residues":585,"molecular_weight":"68283.60156","theoretical_pi":"4.62","general_function":"Involved in [cytochrome c]-lysine N-methyltransferase a","specific_function":"Methyltransferase which mediates trimethylation of Lys- 77 of cytochrome c (CYC1)","reactions":[{"id":2726,"direction":"\u003e","locations":"Cytoplasm, cytosol","altext":"S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm, cytosol","genbank_gene_id":"AY723824","genbank_protein_id":"51830380","gene_card_id":"CTM1","chromosome_location":"chromosome 8","locus":"YHR109W","synonyms":[],"enzyme_classes":["2.1.1.59"],"go_classes":[],"pfams":[],"pathways":[{"name":"Lysine degradation","kegg_map_id":"00310"}],"gene_sequence":"ATGGAGGAAGTGTTCCGTTTTTACTCGAACTCTAGAAATATCTTCATTCATAAAAGCCTTTCATTAAAACCATCCACCATTGATGACCCCAAAAGTGGGTATGGCCTTTTCGTAGAACCTTCGAAGTTCAAGAATGATGAATTGAAAAGTGAAACTATCCAATTGCTCCGAATCCCTAAGCGCTGCACGTTTAATATAAACACACTTCTGGCTCTCTTGGGAGATGAGGACGAATTTTCCTCAAAGGAAGAATTTCAAAGAACTAATGACAAAATTAAGATTGCTCTTCGTGAAATAATGGCTCATCCGAATTTCAGTGTGTTCCTGACAGAAACAAATTTACTCATAATTTATTTCATGATATTTCAAACTATTCGTAGTCGTTATGAGATTCCCGAAAATATCCAATATTATTTAGAAAATGTTTTAATGAGCATTGAAGTAGAAACAGCCATGGATTCTATTGAAAACTTAGCTACTGATTATGGACATTATCCACAGATTTTTGGCCTTCGAGAGACGCTAAATTTATTTAAAGAACTGTTTCACGACGTCTTGAATTTAAGTGATATCAAACATCTTTATTCTGCAATAATTTCACGTTGTTTAGAGATACCAGAAAGGGCCGATACCAAAAGTGAAGAATTCACGGTCCATTCTACTTTAGTCCCTATTGTAGATTTTGCCAACCATGAAGGCACCCAAAAAAATGCTTATTTTGACATCGACCCTTCAAATAATGACGTTTTACTTCTATTGGATACAAGAGCGGTCCAAAGTGAACTCACAAAACCTATTGAAGTTTTCATTAGTTACTCACCAACAGAGGATTTATTTTCCATGCTTGTAACATATGGATTCACCCCAGATTTTAGAGGGAATTCCCAATTTTGGACTGTATCCTTTGACAGGTGCTTTTTAAGAAACTATGATGGACCAGATAAAACTACAAATTTAAGATTGTTTTACAAATGGATGCACATAAATCCAGTGGTACCACTAGTTAAATACGAGCACAACGGAAAGACTCGCTGGTTTCTCAATGACACCACGCCTGAATTTGATATGCTTTTGCTCCCATTCATTCCATCGATAGATGATGGCAAAATTGCTCGGTGGGCGTACGATTCCACATGTCATTTGATGTTCACGAAAATCCATTGTCTGATAAATCCCGAGGCCAACGAACATGCGTTAATGATTGCAGAAAACTACCGCTCTCTCATTAAAGAGAAAGAGTCAAATGGTGACGATTTCATAAATTTACCGCCACTAGCTTGGTCATTGCGTTACAAAGATACAGAAAACGATTGTGTACGGCAAAGACATATATGCAGTGAAGATGCGGTCGCTGTACTTAAACAAGAAGAAATGCAAGACTCAACCAAAACCAAATCCCAGTTTACCAGTTTCTTTCGTAAATTTTTAGAGTTTCGTAGATCCAAAATTATTAGGCCTACCAGTGATTCAAAAGTTGCAAGCATATTATACCAGCAGGAACTGGAAATAATTGCTGACTTAGCAAAAGCTATCGATAGCAGCTCTACCATTTTTTTCAGCGATCTGAATGTTACATTGGACACCGAACCAGAACGGCTCCCCCCTCTAAGGTTTTTAGATGATTACATAGAGATCTCTGCGGATAAGCAGGAGCCAAGCCCAATTTGTGAGGATCTTTCTTATTATACACCCAGCAGGTTTACTGATTTTTTTCAAGAAGAGGTAAGCCAATATGCGGCTTTCTTTCAGGATGACTAG","protein_sequence":"MEEVFRFYSNSRNIFIHKSLSLKPSTIDDPKSGYGLFVEPSKFKNDELKSETIQLLRIPKRCTFNINTLLALLGDEDEFSSKEEFQRTNDKIKIALREIMAHPNFSVFLTETNLLIIYFMIFQTIRSRYEIPENIQYYLENVLMSIEVETAMDSIENLATDYGHYPQIFGLRETLNLFKELFHDVLNLSDIKHLYSAIISRCLEIPERADTKSEEFTVHSTLVPIVDFANHEGTQKNAYFDIDPSNNDVLLLLDTKAVQSELTKPIEVFISYSPTEDLFSMLVTYGFTPDFRGNSQFWTVSFDRCFLRNYDGPDKTTNLRLFYKWMHINPVVPLVKYEHNGKTRWFLNDTTPEFDMLLLPFIPSIDDGKIARWAYDSTCHLMFTKIHCLINPEANEHALMIAENYRSLIKEKESNGDDFINLPPLAWSLRYKDTENDCVRQRHICSEDAVAVLKQEEMQDSTKTKSQFTSFFRKFLEFRRSKIIRPTSDSKVASILYQQELEIIADLAKAIDSSSTIFFSDLNVTLDTEPERLPPLRFLDDYIEISADKQEPSPICEDLSYYTPSRFTDFFQEEVSQYAAFFQDD"},{"created_at":"2011-05-27T03:31:54.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"N6-adenosine-methyltransferase IME4","uniprot_id":"P41833","uniprot_name":"IME4_YEAST","enzyme":true,"transporter":false,"gene_name":"IME4","num_residues":600,"molecular_weight":"69395.39844","theoretical_pi":"8.12","general_function":"Involved in methyltransferase activity","specific_function":"N6-methyltransferase that methylates adenosine residues of some mRNAs and is essential to activate sporulation. N6- methyladenosine (m6A), which is present at internal sites of some mRNAs, is probably required to initiate sporulation. Positive regulator for IME2","reactions":[{"id":2727,"direction":"\u003e","locations":"Nucleus (Probable)","altext":"S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus (Probable)","genbank_gene_id":"D23721","genbank_protein_id":"471168","gene_card_id":"IME4","chromosome_location":"chromosome 7","locus":"YGL192W","synonyms":[],"enzyme_classes":["2.1.1.62"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}],"pfams":[{"name":"MT-A70","identifier":"PF05063"}],"pathways":[],"gene_sequence":"ATGATTAACGATAAACTAGTACATTTTCTGATCCAGAATTATGATGACATCCTAAGAGCACCGCTTTCTGGACAGCTCAAAGATGTGTATTCACTGTACATCAGTGGCGGATACGATGATGAGATGCAGAAGTTGAGAAACGATAAAGACGAGGTCTTACAGTTTGAACAGTTTTGGAATGATCTTCAGGATATTATATTTGCAACGCCGCAGTCCATTCAATTTGACCAGAATCTATTAGTGGCAGATAGGCCAGAAAAAATTGTTTACCTGGACGTTTTTTCCTTGAAAATTCTCTATAACAAGTTCCATGCCTTCTACTATACATTAAAATCGTCCAGTTCTTCATGTGAAGAAAAAGTGTCGAGTTTAACAACAAAACCGGAAGCTGATTCGGAAAAAGACCAACTGCTGGGTAGACTGCTTGGAGTCCTGAACTGGGACGTTAACGTCAGCAACCAGGGGTTACCACGTGAACAACTGAGCAATCGCTTACAAAATTTATTGAGGGAAAAACCATCATCTTTTCAGCTTGCTAAAGAAAGAGCCAAATACACGACCGAGGTCATTGAATACATCCCGATATGTAGTGACTATTCGCATGCATCTCTATTGTCCACCTCGGTGTACATTGTCAATAACAAAATCGTTTCTTTACAATGGTCCAAAATATCCGCATGTCAGGAAAATCACCCAGGATTAATTGAGTGCATTCAATCAAAAATTCACTTTATCCCTAATATCAAACCACAAACTGATATTTCGTTAGGAGATTGTTCCTATTTGGATACCTGTCATAAATTAAATACGTGTCGATACATTCATTACCTGCAATATATTCCGTCATGCTTGCAAGAGCGAGCTGATCGTGAAACTGCGAGTGAAAATAAAAGAATACGGTCAAACGTTTCCATTCCATTTTATACTCTGGGCAATTGCTCCGCACATTGTATCAAAAAGGCTTTACCTGCACAGTGGATCCGTTGCGATGTGCGGAAATTTGATTTTAGGGTTCTTGGAAAGTTTTCGGTAGTTATTGCAGATCCTGCATGGAATATCCATATGAACCTACCATACGGTACTTGCAACGATATTGAACTATTAGGTTTGCCTTTGCACGAACTACAAGATGAAGGTATTATTTTTCTTTGGGTGACGGGTAGAGCTATAGAATTGGGTAAAGAGTCTTTGAATAACTGGGGTTACAACGTGATAAATGAAGTTTCATGGATAAAGACAAACCAACTGGGTAGAACAATTGTTACAGGTCGTACGGGTCATTGGTTAAATCATTCTAAGGAGCATTTATTGGTGGGCTTAAAGGGTAATCCAAAGTGGATCAACAAACATATTGACGTCGATTTGATCGTATCAATGACCAGAGAGACTAGTAGAAAGCCTGATGAACTGTATGGTATAGCAGAACGGTTGGCAGGCACCCATGCCAGAAAACTAGAGATATTCGGAAGGGATCACAATACGCGGCCTGGCTGGTTTACCATCGGAAACCAGTTGACAGGAAATTGCATTTACGAAATGGATGTCGAGAGGAAGTACCAGGAGTTTATGAAGAGCAAAACTGGAACCAGCCACACTGGTACTAAAAAAATCGACAAAAAGCAACCTTCAAAATTACAGCAGCAGCATCAGCAGCAGTATTGGAATAATATGGATATGGGGAGTGGTAAGTATTATGCTGAGGCCAAGCAGAATCCTATGAATCAAAAACATACTCCCTTTGAATCCAAACAGCAACAAAAACAACAATTCCAAACACTAAATAACCTATATTTTGCTCAGTAA","protein_sequence":"MINDKLVHFLIQNYDDILRAPLSGQLKDVYSLYISGGYDDEMQKLRNDKDEVLQFEQFWNDLQDIIFATPQSIQFDQNLLVADRPEKIVYLDVFSLKILYNKFHAFYYTLKSSSSSCEEKVSSLTTKPEADSEKDQLLGRLLGVLNWDVNVSNQGLPREQLSNRLQNLLREKPSSFQLAKERAKYTTEVIEYIPICSDYSHASLLSTSVYIVNNKIVSLQWSKISACQENHPGLIECIQSKIHFIPNIKPQTDISLGDCSYLDTCHKLNTCRYIHYLQYIPSCLQERADRETASENKRIRSNVSIPFYTLGNCSAHCIKKALPAQWIRCDVRKFDFRVLGKFSVVIADPAWNIHMNLPYGTCNDIELLGLPLHELQDEGIIFLWVTGRAIELGKESLNNWGYNVINEVSWIKTNQLGRTIVTGRTGHWLNHSKEHLLVGLKGNPKWINKHIDVDLIVSMTRETSRKPDELYGIAERLAGTHARKLEIFGRDHNTRPGWFTIGNQLTGNCIYEMDVERKYQEFMKSKTGTSHTGTKKIDKKQPSKLQQQHQQQYWNNMDMGSGKYYAEAKQNPMNQKHTPFESKQQQKQQFQTLNNLYFAQ"},{"created_at":"2011-05-27T03:32:46.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"tRNA (guanine-N(1)-)-methyltransferase TRM10","uniprot_id":"Q12400","uniprot_name":"TRM10_YEAST","enzyme":true,"transporter":false,"gene_name":"TRM10","num_residues":293,"molecular_weight":"34520.19922","theoretical_pi":"9.81","general_function":"Involved in methyltransferase activity","specific_function":"Catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs","reactions":[{"id":2728,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm (Probable)","altext":"S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N(1)-methylguanine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"X83121","genbank_protein_id":"600465","gene_card_id":"TRM10","chromosome_location":"chromosome 15","locus":"YOL093W","synonyms":["tRNA methyltransferase 10"],"enzyme_classes":["2.1.1.31"],"go_classes":[],"pfams":[{"name":"tRNA_m1G_MT","identifier":"PF01746"}],"pathways":[],"gene_sequence":"ATGTCCAATGATGAGATAAACCAGAACGAGGAAAAGGTGAAAAGAACACCACCTTTACCGCCTGTGCCAGAAGGCATGTCTAAAAAGCAATGGAAAAAAATGTGTAAAAGACAGAGATGGGAGGAGAATAAAGCCAAATACAATGCGGAACGCCGTGTAAAGAAGAAGAGACTTCGCCATGAAAGAAGTGCGAAGATTCAAGAATACATTGACAGGGGAGAAGAGGTCCCGCAGGAATTGATTAGAGAGCCTCGTATCAATGTGAATCAGACTGATTCTGGGATAGAGATCATACTTGACTGTTCTTTTGATGAGTTAATGAACGACAAGGAAATAGTAAGCTTGTCTAACCAGGTCACCAGGGCATACTCCGCGAATAGAAGGGCGAACCATTTTGCAGAAATAAAGGTGGCCCCATTCGACAAAAGACTAAAGCAAAGGTTTGAAACTACTCTGAAAAATACCAATTATGAAAACTGGAACCATTTTAAATTCCTACCAGACGACAAAATCATGTTTGGAGATGAGCATATAAGTAAGGACAAAATAGTGTATTTAACGGCCGATACAGAGGAAAAGCTGGAGAAGCTGGAACCCGGGATGCGATACATTGTTGGCGGCATTGTAGACAAGAATCGTTATAAAGAATTGTGTCTGAAGAAGGCCCAAAAGATGGGCATTCCTACGCGAAGATTGCCCATTGACGAGTACATCAATCTCGAAGGCAGAAGAGTGTTGACGACAACGCACGTCGTGCAACTCATGCTGAAATACTTTGATGACCATAACTGGAAAAATGCCTTTGAAAGCGTTTTACCACCCAGAAAGCTGGATGCGGAAGCAAAATCCGCAAGCTCTTCGCCAGCTCCAAAGGACACATAG","protein_sequence":"MSNDEINQNEEKVKRTPPLPPVPEGMSKKQWKKMCKRQRWEENKAKYNAERRVKKKRLRHERSAKIQEYIDRGEEVPQELIREPRINVNQTDSGIEIILDCSFDELMNDKEIVSLSNQVTRAYSANRRANHFAEIKVAPFDKRLKQRFETTLKNTNYENWNHFKFLPDDKIMFGDEHISKDKIVYLTADTEEKLEKLEPGMRYIVGGIVDKNRYKELCLKKAQKMGIPTRRLPIDEYINLEGRRVLTTTHVVQLMLKYFDDHNWKNAFESVLPPRKLDAEAKSASSSPAPKDT"},{"created_at":"2011-05-27T03:33:20.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61","uniprot_id":"P46959","uniprot_name":"TRM61_YEAST","enzyme":true,"transporter":false,"gene_name":"GCD14","num_residues":383,"molecular_weight":"43919.30078","theoretical_pi":"7.66","general_function":"Involved in tRNA (adenine-N1-)-methyltransferase activity","specific_function":"Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. GCD14 is also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency","reactions":[{"id":2729,"direction":"\u003e","locations":"Nucleus","altext":"S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N(1)-methyladenine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"Z49400","genbank_protein_id":"1008322","gene_card_id":"GCD14","chromosome_location":"chromosome 10","locus":"YJL125C","synonyms":["General control non-derepressible protein 14","Protein GCD14","tRNA(m1A58)-methyltransferase subunit TRM61","tRNA(m1A58)MTase subunit TRM61"],"enzyme_classes":["2.1.1.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" RNA methyltransferase activity"},{"category":"Function","description":" tRNA methyltransferase activity"},{"category":"Function","description":" tRNA (adenine) methyltransferase activity"},{"category":"Function","description":" tRNA (adenine-N1-)-methyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" RNA modification"},{"category":"Process","description":" RNA methylation"},{"category":"Process","description":" tRNA methylation"}],"pfams":[{"name":"GCD14","identifier":"PF08704"}],"pathways":[],"gene_sequence":"ATGTCAACAAATTGTTTTTCCGGTTACAAAGACCTCATCAAGGAAGGCGATTTAACTCTAATATGGGTTTCTAGAGATAACATCAAACCGGTAAGGATGCATTCCGAAGAGGTATTCAATACTCGTTATGGTTCATTTCCTCATAAGGATATCATAGGTAAACCTTATGGTTCTCAAATTGCTATAAGAACAAAGGGCTCAAATAAGTTTGCATTCGTCCATGTTCTGCAACCAACTCCTGAATTGTGGACTTTGTCGTTACCACACAGAACTCAAATTGTATATACGCCCGACTCTTCCTACATCATGCAAAGGTTGAATTGTAGCCCTCACAGCAGAGTGATCGAGGCAGGTACAGGCTCAGGATCATTTTCGCACGCTTTTGCAAGATCTGTAGGTCATCTTTTTAGTTTTGAATTTCATCACATAAGATACGAACAAGCATTAGAGGAATTCAAAGAGCATGGACTTATTGATGATAACGTTACGATTACACATCGGGATGTTTGCCAAGGTGGATTTCTTATAAAGAAGGGAGACACTACATCTTACGAATTTGGCAATAATGAAACCGCCGCTTCATTGAATGCAAATGTAGTGTTTTTAGATCTGCCGGCTCCCTGGGATGCTATACCTCATCTGGATTCTGTTATTTCCGTAGACGAAAAGGTCGGATTGTGTTGCTTCTCCCCATGCATTGAGCAAGTAGACAAAACATTGGATGTATTAGAGAAATATGGCTGGACGGATGTTGAAATGGTGGAAATTCAAGGTAGACAGTACGAAAGTCGAAGACAAATGGTCAGATCACTCAATGATGCCCTGGAAAGGTTGAGAGATATTAAGAGGCACAAACTCCAGGGTGTAGAAAGACGCAAGCGGATGTTTAACAATACAATAGATTCTAACGATGAAAAAGTTGGAAAAAGAAACGAGGATGGCGTACCATTAACAGAAAAGGCCAAATTTAATCCTTTTGGCAAAGGTTCTCGAATCAAGGAAGGTGATAGTAATTATAAATGGAAGGAGGTCACAAAGATGGAAGCTGAGATCAAATCCCATACCTCATATTTGACTTTTGCATTTAAAGTTGTGAATAGATCAAGAGATGATGAAAAAGTTAACGAAATTCTTCGATCCACGGAAAAATAA","protein_sequence":"MSTNCFSGYKDLIKEGDLTLIWVSRDNIKPVRMHSEEVFNTRYGSFPHKDIIGKPYGSQIAIRTKGSNKFAFVHVLQPTPELWTLSLPHRTQIVYTPDSSYIMQRLNCSPHSRVIEAGTGSGSFSHAFARSVGHLFSFEFHHIRYEQALEEFKEHGLIDDNVTITHRDVCQGGFLIKKGDTTSYEFGNNETAASLNANVVFLDLPAPWDAIPHLDSVISVDEKVGLCCFSPCIEQVDKTLDVLEKYGWTDVEMVEIQGRQYESRRQMVRSLNDALERLRDIKRHKLQGVERRKRMFNNTIDSNDEKVGKRNEDGVPLTEKAKFNPFGKGSRIKEGDSNYKWKEVTKMEAEIKSHTSYLTFAFKVVNRSRDDEKVNEILRSTEK"},{"created_at":"2011-05-27T03:33:57.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"N(2),N(2)-dimethylguanosine tRNA methyltransferase, mitochondrial","uniprot_id":"P15565","uniprot_name":"TRM1_YEAST","enzyme":true,"transporter":false,"gene_name":"TRM1","num_residues":570,"molecular_weight":"64051.80078","theoretical_pi":"9.49","general_function":"Involved in RNA binding","specific_function":"Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Required for the modification of both mitochondrial and cytoplasmic tRNAs","reactions":[{"id":2730,"direction":"\u003e","locations":"Mitochondrion. Nucleus. Cytoplasm.","altext":"S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N(2)-methylguanine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Nucleus. Cytoplasm.","genbank_gene_id":"M17193","genbank_protein_id":"172940","gene_card_id":"TRM1","chromosome_location":"chromosome 4","locus":"YDR120C","synonyms":["tRNA 2,2-dimethylguanosine-26 methyltransferase","tRNA(guanine-26,N(2)-N(2)) methyltransferase","tRNA(m(2,2)G26)dimethyltransferase"],"enzyme_classes":["2.1.1.32"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" tRNA (guanine-N2-)-methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" N-methyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA processing"}],"pfams":[{"name":"TRM","identifier":"PF02005"}],"pathways":[],"gene_sequence":"ATGGAAGGTTTCTTCAGGATACCCCTCAAGCGGGCAAATTTACACGGAATGTTGAAGGCTGCTATATCCAAAATTAAAGCGAATTTTACCGCGTATGGTGCACCAAGAATCAATATTGAGGATTTCAATATAGTCAAGGAAGGAAAAGCAGAAATTCTTTTCCCTAAAAAGGAAACTGTTTTCTATAATCCCATCCAACAATTTAATAGAGATCTAAGTGTTACATGCATCAAGGCGTGGGACAACCTATATGGTGAGGAATGTGGCCAAAAGAGAAATAATAAAAAAAGTAAGAAGAAAAGGTGCGCGGAAACTAACGATGATTCTTCCAAGCGTCAAAAAATGGGAAACGGGTCACCAAAAGAAGCCGTTGGTAATTCTAATCGAAACGAACCTTATATAAATATTTTGGAAGCATTGTCAGCCACTGGGTTAAGAGCCATTAGGTATGCTCATGAAATTCCCCATGTGAGGGAAGTTATTGCTAACGATTTACTTCCAGAGGCTGTCGAATCTATAAAACGAAACGTTGAATATAATAGTGTCGAAAACATTGTCAAGCCAAACCTTGATGATGCTAATGTCTTAATGTACCGTAACAAAGCGACGAATAATAAGTTTCACGTCATCGACTTGGATCCTTACGGTACCGTTACACCTTTTGTAGATGCGGCTATTCAGAGTATTGAGGAGGGTGGTCTAATGCTGGTAACTTGCACTGATTTATCCGTTTTGGCCGGTAACGGATACCCAGAAAAGTGTTTTGCCTTATATGGTGGTGCAAATATGGTTTCTCATGAATCAACTCACGAAAGTGCGCTGAGACTAGTATTGAACTTACTAAAGCAAACTGCCGCGAAATACAAGAAAACTGTGGAACCGCTTTTGTCGTTGAGCATTGACTTTTACGTCAGAGTTTTTGTCAAAGTCAAAACAAGCCCGATTGAAGTCAAAAACGTTATGTCAAGTACTATGACTACTTACCATTGTTCCCGTTGCGGCTCTTACCACAATCAACCTCTGGGCAGAATTTCTCAACGCGAAGGTAGGAACAACAAAACATTCACCAAATACTCGGTTGCGCAAGGGCCTCCGGTTGATACTAAATGTAAGTTCTGCGAGGGGACATACCATTTAGCTGGTCCAATGTATGCAGGACCTCTACACAACAAGGAGTTCATCGAGGAGGTGTTGAGAATTAATAAAGAAGAGCATCGTGACCAGGATGATACATATGGAACACGTAAAAGAATTGAAGGTATGCTATCTCTAGCTAAGAATGAATTATCCGATTCGCCATTCTATTTCAGTCCTAACCATATTGCATCGGTAATAAAATTACAAGTACCTCCCTTGAAAAAAGTAGTCGCAGGCCTAGGTTCCCTAGGCTTTGAATGTTCATTGACACATGCCCAACCATCGTCCCTAAAGACTAACGCTCCATGGGATGCAATCTGGTATGTGATGCAGAAATGTGATGATGAGAAGAAAGACTTAAGCAAAATGAATCCAAATACTACGGGCTATAAGATTTTATCGGCAATGCCAGGATGGTTGAGTGGCACTGTCAAATCAGAGTATGACTCAAAGCTGTCGTTCGCACCAAATGAACAAAGCGGTAATATTGAAAAACTAAGGAAGCTAAAAATTGTGAGATATCAGGAAAATCCAACAAAGAATTGGGGCCCAAAAGCCCGTCCCAACACTTCATAA","protein_sequence":"MEGFFRIPLKRANLHGMLKAAISKIKANFTAYGAPRINIEDFNIVKEGKAEILFPKKETVFYNPIQQFNRDLSVTCIKAWDNLYGEECGQKRNNKKSKKKRCAETNDDSSKRQKMGNGSPKEAVGNSNRNEPYINILEALSATGLRAIRYAHEIPHVREVIANDLLPEAVESIKRNVEYNSVENIVKPNLDDANVLMYRNKATNNKFHVIDLDPYGTVTPFVDAAIQSIEEGGLMLVTCTDLSVLAGNGYPEKCFALYGGANMVSHESTHESALRLVLNLLKQTAAKYKKTVEPLLSLSIDFYVRVFVKVKTSPIEVKNVMSSTMTTYHCSRCGSYHNQPLGRISQREGRNNKTFTKYSVAQGPPVDTKCKFCEGTYHLAGPMYAGPLHNKEFIEEVLRINKEEHRDQDDTYGTRKRIEGMLSLAKNELSDSPFYFSPNHIASVIKLQVPPLKKVVAGLGSLGFECSLTHAQPSSLKTNAPWDAIWYVMQKCDDEKKDLSKMNPNTTGYKILSAMPGWLSGTVKSEYDSKLSFAPNEQSGNIEKLRKLKIVRYQENPTKNWGPKARPNTS"},{"created_at":"2011-05-27T03:34:40.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"tRNA (cytosine-5-)-methyltransferase NCL1","uniprot_id":"P38205","uniprot_name":"NCL1_YEAST","enzyme":true,"transporter":false,"gene_name":"NCL1","num_residues":684,"molecular_weight":"77878.0","theoretical_pi":"7.39","general_function":"Involved in RNA binding","specific_function":"Methylates cytosine to m5C at several positions in different tRNAs and pre-tRNAs containing intron. Able to modify tRNAs at all four positions (34, 40, 48 and 49) at which m5C has been found in tRNAs. May be involved in ribosome biogenesis as its disruption leads to increased sensitivity to the antibiotic paromomycin","reactions":[{"id":2731,"direction":"\u003e","locations":"Nucleus, nucleolus","altext":"S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus, nucleolus","genbank_gene_id":"X77291","genbank_protein_id":"602895","gene_card_id":"NCL1","chromosome_location":"chromosome 2","locus":"YBL024W","synonyms":["Multisite-specific tRNA:m5C-methyltransferase","tRNA methyltransferase 4"],"enzyme_classes":["2.1.1.29"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" RNA binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Nol1_Nop2_Fmu","identifier":"PF01189"}],"pathways":[],"gene_sequence":"ATGGCTAGAAGAAAGAATTTCAAAAAAGGGAACAAGAAGACTTTTGGTGCTCGTGATGACTCGAGAGCTCAAAAAAACTGGTCTGAACTGGTAAAGGAAAATGAAAAATGGGAAAAATACTATAAGACTTTAGCTCTTTTCCCAGAAGATCAATGGGAAGAATTTAAAAAGACATGTCAAGCTCCACTTCCTCTAACTTTTAGAATTACAGGTTCTAGAAAGCATGCCGGTGAGGTCCTGAATTTGTTTAAAGAAAGACATCTACCAAACTTGACTAATGTTGAGTTTGAAGGTGAGAAGATTAAGGCCCCTGTAGAATTACCTTGGTATCCAGACCATCTTGCTTGGCAATTGGACGTTCCTAAGACGGTTATTAGAAAGAATGAACAATTCGCAAAAACTCAGAGATTTTTAGTTGTTGAAAATGCCGTTGGTAATATCTCAAGACAAGAAGCCGTTTCAATGATTCCTCCAATCGTTCTAGAAGTAAAACCTCATCACACTGTTTTAGATATGTGTGCTGCTCCTGGCTCCAAAACTGCTCAATTAATCGAAGCCTTGCACAAGGATACAGATGAACCATCTGGTTTCGTTGTAGCTAATGATGCCGATGCCAGAAGATCTCATATGTTGGTTCACCAATTGAAGAGATTGAACAGTGCCAACTTGATGGTTGTCAACCATGACGCCCAATTCTTCCCACGTATCAGATTACATGGCAACTCAAATAACAAGAATGATGTTTTAAAATTTGACAGAATCCTGTGTGACGTTCCATGTTCTGGTGATGGTACCATGAGGAAAAATGTTAATGTTTGGAAAGACTGGAACACACAAGCAGGTCTTGGTTTGCATGCTGTTCAGCTGAATATATTAAACAGGGGTTTGCATCTTCTAAAGAACAACGGTAGATTGGTTTACTCAACCTGTTCTTTAAATCCTATTGAAAATGAAGCGGTTGTTGCCGAAGCGTTAAGAAAGTGGGGTGACAAGATTAGATTAGTTAACTGTGATGATAAGCTTCCTGGCCTAATAAGATCCAAGGGTGTATCCAAATGGCCTGTCTATGACAGAAATTTGACTGAGAAAACCAAAGGAGACGAAGGTACACTAGATAGTTTCTTTTCACCATCTGAAGAAGAGGCATCGAAATTCAATTTACAAAATTGTATGAGGGTTTATCCTCACCAACAAAACACAGGCGGATTTTTCATTACTGTTTTCGAAAAAGTCGAAGATAGCACTGAGGCGGCTACAGAGAAACTATCTTCTGAAACCCCAGCTCTAGAGTCTGAAGGACCTCAAACAAAGAAAATAAAGGTAGAAGAAGTCCAAAAGAAAGAAAGACTACCACGTGACGCGAACGAAGAGCCTTTTGTTTTCGTTGATCCACAGCACGAAGCTTTAAAAGTTTGTTGGGATTTCTACGGCATCGATAATATTTTCGACAGAAACACTTGTTTAGTGCGTAACGCCACTGGTGAACCAACAAGAGTGGTTTACACTGTGTGTCCAGCATTGAAGGATGTTATTCAAGCGAATGACGATAGGTTGAAGATTATTTATTCTGGTGTAAAATTGTTTGTCTCTCAAAGAAGTGATATCGAATGTTCATGGAGAATCCAAAGTGAATCATTGCCAATAATGAAACACCATATGAAATCTAATAGAATTGTTGAAGCTAATTTAGAGATGTTAAAACACTTGTTAATCGAATCTTTCCCTAACTTTGACGACATTCGTTCGAAGAACATCGATAATGATTTTGTTGAAAAGATGACAAAATTAAGCTCTGGTTGCGCCTTTATTGATGTGTCAAGAAATGACCCTGCCAAAGAAAACTTATTCTTGCCTGTGTGGAAAGGCAACAAGTGTATCAATTTGATGGTTTGTAAAGAAGATACTCATGAGCTATTATATAGGATCTTTGGTATTGATGCGAATGCCAAGGCTACTCCAAGCGCTGAAGAAAAAGAAAAAGAAAAAGAAACGACTGAATCTCCCGCAGAAACTACTACCGGAACCTCTACTGAAGCTCCTAGCGCTGCTAATTGA","protein_sequence":"MARRKNFKKGNKKTFGARDDSRAQKNWSELVKENEKWEKYYKTLALFPEDQWEEFKKTCQAPLPLTFRITGSRKHAGEVLNLFKERHLPNLTNVEFEGEKIKAPVELPWYPDHLAWQLDVPKTVIRKNEQFAKTQRFLVVENAVGNISRQEAVSMIPPIVLEVKPHHTVLDMCAAPGSKTAQLIEALHKDTDEPSGFVVANDADARRSHMLVHQLKRLNSANLMVVNHDAQFFPRIRLHGNSNNKNDVLKFDRILCDVPCSGDGTMRKNVNVWKDWNTQAGLGLHAVQLNILNRGLHLLKNNGRLVYSTCSLNPIENEAVVAEALRKWGDKIRLVNCDDKLPGLIRSKGVSKWPVYDRNLTEKTKGDEGTLDSFFSPSEEEASKFNLQNCMRVYPHQQNTGGFFITVFEKVEDSTEAATEKLSSETPALESEGPQTKKIKVEEVQKKERLPRDANEEPFVFVDPQHEALKVCWDFYGIDNIFDRNTCLVRNATGEPTRVVYTVCPALKDVIQANDDRLKIIYSGVKLFVSQRSDIECSWRIQSESLPIMKHHMKSNRIVEANLEMLKHLLIESFPNFDDIRSKNIDNDFVEKMTKLSSGCAFIDVSRNDPAKENLFLPVWKGNKCINLMVCKEDTHELLYRIFGIDANAKATPSAEEKEKEKETTESPAETTTGTSTEAPSAAN"},{"created_at":"2011-05-27T03:35:14.000Z","updated_at":"2011-07-22T17:54:22.000Z","name":"Protein-S-isoprenylcysteine O-methyltransferase","uniprot_id":"P32584","uniprot_name":"STE14_YEAST","enzyme":true,"transporter":false,"gene_name":"STE14","num_residues":239,"molecular_weight":"27887.40039","theoretical_pi":"8.11","general_function":"Involved in protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity","specific_function":"Mediates C-terminal methylation of the isoprenylated C- terminal cysteine in A-factor mating pheromone and Ras proteins","reactions":[{"id":2732,"direction":"\u003e","locations":"Membrane; Multi-pass membrane protein (Probable)","altext":"S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"24-44;48-68;89-109;111-131;183-203","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"L07952","genbank_protein_id":"172018","gene_card_id":"STE14","chromosome_location":"chromosome 4","locus":"YDR410C","synonyms":["Isoprenylcysteine carboxylmethyltransferase","Prenylated protein carboxyl methyltransferase","PPMT","Prenylcysteine carboxyl methyltransferase","pcCMT"],"enzyme_classes":["2.1.1.100"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" protein methyltransferase activity"},{"category":"Function","description":" protein carboxyl O-methyltransferase activity"},{"category":"Function","description":" protein C-terminal carboxyl O-methyltransferase activity"},{"category":"Process","description":" protein amino acid alkylation"},{"category":"Process","description":" protein amino acid methylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" C-terminal protein amino acid methylation"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" post-translational protein modification"}],"pfams":[{"name":"ICMT","identifier":"PF04140"}],"pathways":[],"gene_sequence":"ATGCACCAAGATTTTCAAGAAGACGAGCATGAGTATCCAGACATCAGACGCAATCCGCTGCATGAGGTGACCATGACTTCCTACATACTGGGGATTCTTTTAGGTATATTTGTTGGTCTTTTTCCACAAATTAGATTCAAGAATTTTAACCTCTTTATTATTGCCCTGTCCTTATTCCATTTTTTGGAGTATTATATTACAGCTAAATACAATCCTCTTAAGGTACATTCAGAGTCCTTTCTTCTGAACAACGGCAAAAGTTACATGGCGGCACATTCCTTTGCTATTCTGGAATGCCTCGTAGAAAGCTTTCTTTTTCCTGATCTGAAAATTTTTAGCTACTCTCTAGCTACCAAGCTTTGTACAGTACTTGGATGTCTTCTAGTTATTCTGGGACAATATACCAGAACTATTGCTATGCATACTGCGGGACATTCCTTTTCTCATATTGTGAAGACCAAGAAGGAGTCCGATCATGTTTTAGTGAAAACTGGCGTTTACTCCTGGTCAAGACATCCAAGTTATCTTGGGTTCTTTTGGTGGGCAATTGGCACTCAGCTACTGCTTCTAAATCCCCTATCATTGGTTATTTTCATTTTTGTACTTTGGAAATTTTTCAGTGATAGAATTCGTGTGGAAGAAAAATATTTGATAGAGTTCTTTAGCGCGGAATACATAGAATACAAGAATAAGGTTGGTGTCGGAATACCTTTTATATAA","protein_sequence":"MHQDFQEDEHEYPDIRRNPLHEVTMTSYILGILLGIFVGLFPQIRFKNFNLFIIALSLFHFLEYYITAKYNPLKVHSESFLLNNGKSYMAAHSFAILECLVESFLFPDLKIFSYSLATKLCTVLGCLLVILGQYTRTIAMHTAGHSFSHIVKTKKESDHVLVKTGVYSWSRHPSYLGFFWWAIGTQLLLLNPLSLVIFIFVLWKFFSDRIRVEEKYLIEFFSAEYIEYKNKVGVGIPFI"},{"created_at":"2011-05-27T03:35:46.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"tRNA (uridine-2'-O-)-methyltransferase TRM7","uniprot_id":"P38238","uniprot_name":"TRM7_YEAST","enzyme":true,"transporter":false,"gene_name":"TRM7","num_residues":310,"molecular_weight":"34700.19922","theoretical_pi":"7.99","general_function":"Involved in methyltransferase activity","specific_function":"Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop","reactions":[{"id":2733,"direction":"\u003e","locations":"Nucleus, nucleolus;Cytoplasm. Nucleus;Cytoplasm","altext":"S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z35930","genbank_protein_id":"536303","gene_card_id":"TRM7","chromosome_location":"chromosome 2","locus":"YBR061C","synonyms":[],"enzyme_classes":["2.1.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleic acid binding"},{"category":"Process","description":" rRNA processing"},{"category":"Process","description":" rRNA modification"},{"category":"Process","description":" rRNA methylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" one-carbon metabolic process"},{"category":"Process","description":" methylation"},{"category":"Process","description":" rRNA metabolic process"}],"pfams":[{"name":"FtsJ","identifier":"PF01728"}],"pathways":[],"gene_sequence":"ATGGGTAAGAGCAGCAAAGATAAAAGAGATTTGTACTATAGAAAAGCAAAAGAGCAGGGCTATAGGGCTAGATCTGCTTTCAAACTACTTCAACTCAATGACCAATTTCATTTCCTGGATGATCCAAACTTAAAAAGAGTTGTAGATTTGTGTGCAGCACCAGGTTCATGGTCACAAGTGCTCTCGAGAAAACTGTTTGATGAAAGTCCCAGTTCAGATAAGGAGGACAGGAAAATTGTCTCTGTCGATTTACAACCGATGTCCCCCATACCTCATGTGACAACGTTGCAAGCCGATATCACTCATCCTAAAACATTGGCGAGGATTCTAAAACTGTTTGGCAACGAAAAGGCCGATTTTGTTTGTAGTGATGGTGCACCTGATGTTACTGGGTTACACGATCTTGACGAATACGTGCAACAACAGTTAATTATGAGTGCGCTGCAACTTACTGCATGCATTCTGAAAAAAGGTGGAACTTTTGTGGCAAAGATCTTCAGAGGTCGTGATATAGATATGCTATATTCCCAATTGGGCTATCTATTCGATAAAATCGTTTGCGCAAAGCCAAGATCATCAAGAGGTACATCTCTGGAAGCTTTTATTGTTTGTTTAGGCTATAACCCACCATCCAATTGGACACCAAAATTAGATGTAAATACATCCGTTGATGAATTTTTTCAAGGCTGTTTTTTGAATAAATTGTGTATATCAGACAAATTGTCTCATTGGAATGAAGAGGAGAGAAACATAGCCGAATTTATGGCTTGTGGAAGTCTTCAAAGTTTCGACTCAGATGCCACTTATCATGACCTACCTTCTTCGGTTGCAGGCACTTCATCGTCCTTAGATCCTGTTCAAAGCCCGACGAACCCTCCCTACAAGAAAGCTTTGGAATTAAAAAGGAGCGGGAAACTCACTAGATCAGTTTGA","protein_sequence":"MGKSSKDKRDLYYRKAKEQGYRARSAFKLLQLNDQFHFLDDPNLKRVVDLCAAPGSWSQVLSRKLFDESPSSDKEDRKIVSVDLQPMSPIPHVTTLQADITHPKTLARILKLFGNEKADFVCSDGAPDVTGLHDLDEYVQQQLIMSALQLTACILKKGGTFVAKIFRGRDIDMLYSQLGYLFDKIVCAKPRSSRGTSLEAFIVCLGYNPPSNWTPKLDVNTSVDEFFQGCFLNKLCISDKLSHWNEEERNIAEFMACGSLQSFDSDATYHDLPSSVAGTSSSLDPVQSPTNPPYKKALELKRSGKLTRSV"},{"created_at":"2011-05-27T03:37:43.000Z","updated_at":"2011-05-29T05:06:39.000Z","name":"Trimethylguanosine synthase","uniprot_id":"Q12052","uniprot_name":"TGS1_YEAST","enzyme":true,"transporter":false,"gene_name":"TGS1","num_residues":315,"molecular_weight":"36526.80078","theoretical_pi":"9.99","general_function":"Involved in methyltransferase activity","specific_function":"Catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylates the m3G cap on TLC1 telomerase which affects telomere silencing and telomere length regulation. Required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis. Involved in nucleolar structural organization","reactions":[{"id":2734,"direction":"\u003e","locations":"Nucleus, nucleolus","altext":"S-adenosyl-L-methionine + m(7)G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(2,7)G(5')pppR-RNA.","export":false,"pw_reaction_id":null,"source":null},{"id":2735,"direction":"\u003e","locations":"Nucleus, nucleolus","altext":"S-adenosyl-L-methionine + m(2,7)G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(2,2,7)G(5')pppR-RNA.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus, nucleolus","genbank_gene_id":"X96770","genbank_protein_id":"1403552","gene_card_id":"TGS1","chromosome_location":"chromosome 16","locus":"YPL157W","synonyms":["Cap-specific guanine-N2 methyltransferase","snRNA/snoRNA cap hypermethylase"],"enzyme_classes":["2.1.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" RNA modification"},{"category":"Process","description":" RNA processing"},{"category":"Process","description":" RNA methylation"},{"category":"Process","description":" RNA capping"}],"pfams":[{"name":"Methyltransf_15","identifier":"PF09445"}],"pathways":[],"gene_sequence":"ATGGGAAGGACATTTATTCATGCTTCGAAAATAAAACATGCGGCACGCAAAAGAAAACATCATTCCAACTTTAGAACTCTGATCAAATTATTGAACAATGATGCCTATAAGATAGAATCATCAAAACCGTTGAAAAATGGTAAACTTTTCAAATACTGGAAAAATAGGCGTAGATTGTTTTCAAAGATAGATTCGGCGTCGATATATATGACTGATGAGCTGTGGTTCAGTGTGACGCCCGAAAGAATTGCCTGCTTCCTGGCAAATTTTGTTAAGGCATGCATGCCAAATGCCGAAAGAATACTGGATGTTTTCTGTGGTGGGGGCGGGAACACCATACAATTTGCCATGCAATTTCCTTACGTCTATGGAGTGGACTACAGTATTGAACACATATATTGTACTGCGAAAAACGCCCAAAGCTACGGTGTGGACGACAGAATATGGCTGAAGCGGGGATCCTGGAAAAAGCTAGTCTCTAAGCAGAAACTTTCCAAAATAAAGTACGACTGTGTATTTGGATCACCCCCGTGGGGTGGTCCAGAATACTTAAGAAACGATGTGTATGACTTAGAGCAACATCTAAAGCCTATGGGGATTACCAAGATGTTGAAAAGTTTTCTTAAACTAAGCCCTAATGTGATTATGTTTTTGCCAAGGAACTCTGATTTGAACCAGCTTTCTCGAGCTACGAGGAAAGTACTAGGTCCATTTGCCAAATGTAAAGTATTATATGTAAAGGAGAATGGATATATGAAAGGAATATTTTGCATGTGGGGGGAATGCTTTTTTAACTACGAACCAGCAAGTACGGAGAATAGTCGAAGGGAGTCGTCCGAAAAGGAAGAGCTGAGTTCTGAAAACGAAGAGCTCTCGAAAAGAAAAAAGCATGAATCCACAACAACGACCAAAGATAATACTGTAGACATTTACGACGTAAATGGTTAA","protein_sequence":"MGRTFIHASKIKHAARKRKHHSNFRTLIKLLNNDAYKIESSKPLKNGKLFKYWKNRRRLFSKIDSASIYMTDELWFSVTPERIACFLANFVKACMPNAERILDVFCGGGGNTIQFAMQFPYVYGVDYSIEHIYCTAKNAQSYGVDDRIWLKRGSWKKLVSKQKLSKIKYDCVFGSPPWGGPEYLRNDVYDLEQHLKPMGITKMLKSFLKLSPNVIMFLPRNSDLNQLSRATRKVLGPFAKCKVLYVKENGYMKGIFCMWGECFFNYEPASTENSRRESSEKEELSSENEELSKRKKHESTTTTKDNTVDIYDVNG"},{"created_at":"2011-05-27T03:39:08.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"tRNA guanosine-2'-O-methyltransferase TRM3","uniprot_id":"Q07527","uniprot_name":"TRM3_YEAST","enzyme":true,"transporter":false,"gene_name":"TRM3","num_residues":1436,"molecular_weight":"165046.0","theoretical_pi":"5.96","general_function":"Involved in RNA binding","specific_function":"Specifically methylates guanosine-18 in various tRNAs","reactions":[{"id":2736,"direction":"\u003e","locations":"Cytoplasm","altext":"S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z74160","genbank_protein_id":"1431162","gene_card_id":"TRM3","chromosome_location":"chromosome 4","locus":"YDL112W","synonyms":["tRNA [Gm18] methyltransferase","tRNA methylase 3"],"enzyme_classes":["2.1.1.34"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" RNA methyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" RNA processing"}],"pfams":[{"name":"SpoU_methylase","identifier":"PF00588"}],"pathways":[],"gene_sequence":"ATGGTTGGAGGTGCTCTCATCTGCAAATATTTACCACGCGAAGAGCAACTAAAGCTTATATCAGACTTGATTCAGAATGACAGCTTAGAAGAGGTGCTGGAGTTGATTGAAACTTCGCCACTGGATATAACGACGGACAGCAACATTGAAACACCAATCTTTGAAAAAATTACTGAGCAGGTCATTGCGTATGCTAGTATAGACGGTGAAGCCAGGGAAATGTTTCGCTCTTCGAGGGCTGAAATGAACAAGGCGCTAAGAACTTCTGCACAATTACTATGTTGTTTACCCAGTGTATGGCATAAATTTCAGGTGTGGATGAGCTACCGGTTAAATGACATCATTAGCGAAAACTATAAACATCTCTTCAATGACAACTTTGGAAAAAAGATTGTACAACCATTTTTCGATTCTTTTGCTGAGGAACAAAACGCTAATATCAAGCATGAAAATCTGCACTTAGATATCCTTAGCCTGCTTCACTACTTAGAAGTTGTATATTTATTTGACGAATGTAAGAATGGTATATCGTCCAAATGCCTAGATTTTATCATTGTTCCATTGTTAGGCTGTAATTCGGAAGAGATTGCTGATTCCTGCTCCAAGTTAATGAGATGGCATATCAAATATTTATCGAAATGCTGCAATACCGATAGTAACTTTGATAAGCTCATTTGGACATTTATCAAACAATTGTACGCTGAAGGCTCCCAACAAGCTTGGAAGCAAAAGAACAGTTTATCTTTTCTCCTAAGATTCCTTTTAGCAGCAGAGTTGTCTCCTGAACTTATTACTTATATAAAGACCGATGCTTATTGGAGGCACATTCAAACAGAGCTGGATAATGATGTGCACGAACACAGAAAATTGGCACTCTCAATTCTTAAATTAACAATTCAAAAACTGTCATCTCATGGTATAACATTGCAAACAACATTTTATAAATGCAATGATCTAGCAAATATCGAGATGCTGGGTAGCTGGAAGAAATTCACCACCTTATATGAAATGATTGCTCTGGACACATCATTGAATCAAATACAAGCGGCCAAACAAGATATAATAAAAATTTTTGATAACGAGCATTTACACCATAGTTGGGGCCTTATCTTGCTTTCTACGGGATTGAAATCATCAATGGAGAGTGTCAGAAAATACATGATGACGTTAATGTTCTCGATTACAAATATGTCAGCATTCTCTTCAAACTTGCCATTATTGACAAAAACTCTTCTTCCAGCTGCAATGTCCGCTCATTATTTTGATGTAAAAGGTGTCAGTTGTCCCCATGGTGAAAAACTTTCATTATTTGTCAATAACTTACTTTCCCAAACAACAGAAGGCATATCAGATATATTATTTGAAATTTTGAAATTATTGGTGGAAAAAGGGACCTCTTTTGACCCTTCTAGGATATACTTGTCCTACGGTATCTTAGTTTTCTTCCAGAATAACAAACAGAAAACAATCAACTCTGACCATTTGAGTCTGATCAGGAAATTGTACGATTTTGCAGCCGAAGAAGAGGTTCTCGAAACTACAATCCAAACAATTTACTTGAAGTTCTTACTGTACATTGATCCATCTGTCTCCGCATCTGAATTATTGTTTACATTAGTTTCACACATTAAGTTAAAGGGAGGGACATACAAATATGTTGAGCCTCTTTTTGAAGATTATAGGGATCTTGCCGTTTCTCACTTTGACGATTTGCAAGCGAAAGAAAACTTGACGACAAACATCGGAAAGGATACTATTTTTGACCTCTTAGCATCTATCATCTTCGATTTCAAGGATATTGATATTACTCCCGATTTTTTAATTGAAGTTGCGAAGTCGAAGCAAGATATACCCGTTTACACTTCAAAGGCAGTTACTTTTCTAACTCAGCTACTTTCAGGCGAACCTTCGAACGGTTATACCTATGAAAATGCAACCGCTTTGTTGTCTTACCCAAATTTTACAATATCTACATGGAAATCCATCAATGTGAATAATTTATTTAAGTCGGTAATGGAAAAATTTTCGCTTGATAAATTCAAGTTCTTTGCTGAAATTTACCAGAAGACTTATGAATGTAGGTTCGATACAATCGAGCTAAATTTTAATGACCTTCTGAGCCTATATGAAATGGTTAAAAAGTCTGCCAATCAGTGTTCAAGAGAGAGCTTTAAAGTGAAGGACAGCGCTTATTCTTCTTACTTTGAACTTTTAAATACCTTCCTGAAAACATACGCCTTAAATCGTGACTCTTCTGAAGGAAATGATGATGAGCTTCACATACTACTACGCTTAGTTGACGAGAATATTAACAAAGATAATGGGAATTATCTGGGGAACCTGGCAGTCTGTAAATTATTGTACTTTATCATAGATTCCTACATCCATTGCTCCACATCTGTTTCTGATGATGATATTTTCATAGTGAAATTCATTTTTGAGAAATTTTCGTTTATATGGGAATGTATTAATAGTGAAAGATTAGTTTTGAAGGAAAGGGATCTGCATTTGATGCTAATTAAGGGATTATTTCATCCTGTGATCCTGTACTTTGGATCAAATCAGTATATCGATACTTTGACCTCGAAGTTGGAGGAACATGCACAAACGATTATATCATTGAGTTATTCCAGAAGAAGCCTACTCCCTCTTCTCGGATCACAACTCAGAGTATTTATGAAGTTTTATGGGAAATTGTTAAGAGAAGATGTCAACTATTGGTGGTTGATTAACATTATAGTAGGTGTTTTCAAACAGCCGCAAATGGATGTCAACCTTTACAAGCTCAAACCTGTTATTTCCAGCCTATTTGACCACAAACTGAACAATTATTACATAAAAGGCGATGAACTTTATGAAAAGGTGTACGGACCCGACGAAATATTGGCTAGAGTATCTATTATTGATTCTATTTTATATGCAAATGATCAGTTGAAAATTCGATTAATCGAAAAAGTTACTGAAAAAACAAACGCACTTTATGCTATAAAGAGAACCGACGGTGCCGAAGCGTTACAGAGGTTGTTGCAGTGGCAATTGTTATTATTATCACTACTAACCACCAATGAAAAAAAATTAAGCGAAACTAGCATGATCAGAATTCTAAAGAGTATCGAGGATGAAAGTTCACCACTAGTAAGAGTATATAAAGAATGGTTCATTTCCTCAAAGGTTGTTGATTATTATAAAACTGGCAATCCAAAATTTGCTGAGGATTATCTCTTCTCATTGCTGGAGGATCATAGCAAACCGGTGTTTGTAGTTAGCGCAGAAAAAATATGCTTTATGGTGTTGAAAGATTTAAGAAACGACGAAAAGAAATATGGATTTACACAGTTACTAGACAGATTCATTTGCACGTTAGTTCCTAACGCAGCTTCAAACAAACCTCTGGTAAGGCATTTTTCTAATTCTCTAATAATTTCATTATGGCCTACATTCAAAGCCTACCTATCGGATCACACACTGAGAAACATCATTGAGAACTTATATTCCAATGCCAAAAAGACTCAAATATTTGGTCAATATCGTGCCGGGGATGCCAACATATGGGATCTGAAGGGTGATAGGAAATTAACGAACATGTTTGGTGGTGTGCTCAAAAAAGTTACCGACCATGATTGCCCGTACATTTCTGAGTCTGTTTTCGAAAAATATTTGCAGGAGAAAGATATTGTTCCTATAGGTACCGATGAAAGGTCCTTATGGCTTGATAAAAGAGACACCAATACGGAATCTGTTAACAACGCGAACATCTCCTGTGACACTTCTCCACTGCAAACAAAAAGTGGAGCTTGGGAAACCGTTCTGGATCTGGACAATAAAAAATCGAATGATGTCGTTACACGTTCTGAATTGATTGTGGTATCTTCATTAGTTGATAAGCCGCCAAACCTGGGAGGTATTTGTAGGTTATGTGATGTTTTAGGTGTGGGACTGCTTACTGTACAAGACATCAAAGTCAAAAACCATCCTCAATTTAAAAATGTTGCTGTGACTGCTGATAGATGGATGCCCATGGAGGAAGTTGCCCTAGATGAGATTGCAAGTTTCATGAAAGAGAAAAAGAAGGAAGGGTACACATTAATTGGGCTAGAGCAAACGGATAAATCAGTGAAGCTAGACAACAATTTCCAATTCCCTAAAAAATCATTGATCTTGCTAGGAACCGAAGCATTCGGTATTCCGGGGACTTTGTTAAGCGAATTGGATTTATGTTTAGAGATTCAACAATTTGGTGTGATCAGATCAATGAATATTCAAACGGCAACCGCAGTTATCGTTCATTCCTATACAGTTCAACACATGTAA","protein_sequence":"MVGGALICKYLPREEQLKLISDLIQNDSLEEVLELIETSPLDITTDSNIETPIFEKITEQVIAYASIDGEAREMFRSSRAEMNKALRTSAQLLCCLPSVWHKFQVWMSYRLNDIISENYKHLFNDNFGKKIVQPFFDSFAEEQNANIKHENLHLDILSLLHYLEVVYLFDECKNGISSKCLDFIIVPLLGCNSEEIADSCSKLMRWHIKYLSKCCNTDSNFDKLIWTFIKQLYAEGSQQAWKQKNSLSFLLRFLLAAELSPELITYIKTDAYWRHIQTELDNDVHEHRKLALSILKLTIQKLSSHGITLQTTFYKCNDLANIEMLGSWKKFTTLYEMIALDTSLNQIQAAKQDIIKIFDNEHLHHSWGLILLSTGLKSSMESVRKYMMTLMFSITNMSAFSSNLPLLTKTLLPAAMSAHYFDVKGVSCPHGEKLSLFVNNLLSQTTEGISDILFEILKLLVEKGTSFDPSRIYLSYGILVFFQNNKQKTINSDHLSLIRKLYDFAAEEEVLETTIQTIYLKFLLYIDPSVSASELLFTLVSHIKLKGGTYKYVEPLFEDYRDLAVSHFDDLQAKENLTTNIGKDTIFDLLASIIFDFKDIDITPDFLIEVAKSKQDIPVYTSKAVTFLTQLLSGEPSNGYTYENATALLSYPNFTISTWKSINVNNLFKSVMEKFSLDKFKFFAEIYQKTYECRFDTIELNFNDLLSLYEMVKKSANQCSRESFKVKDSAYSSYFELLNTFLKTYALNRDSSEGNDDELHILLRLVDENINKDNGNYLGNLAVCKLLYFIIDSYIHCSTSVSDDDIFIVKFIFEKFSFIWECINSERLVLKERDLHLMLIKGLFHPVILYFGSNQYIDTLTSKLEEHAQTIISLSYSRRSLLPLLGSQLRVFMKFYGKLLREDVNYWWLINIIVGVFKQPQMDVNLYKLKPVISSLFDHKLNNYYIKGDELYEKVYGPDEILARVSIIDSILYANDQLKIRLIEKVTEKTNALYAIKRTDGAEALQRLLQWQLLLLSLLTTNEKKLSETSMIRILKSIEDESSPLVRVYKEWFISSKVVDYYKTGNPKFAEDYLFSLLEDHSKPVFVVSAEKICFMVLKDLRNDEKKYGFTQLLDRFICTLVPNAASNKPLVRHFSNSLIISLWPTFKAYLSDHTLRNIIENLYSNAKKTQIFGQYRAGDANIWDLKGDRKLTNMFGGVLKKVTDHDCPYISESVFEKYLQEKDIVPIGTDERSLWLDKRDTNTESVNNANISCDTSPLQTKSGAWETVLDLDNKKSNDVVTRSELIVVSSLVDKPPNLGGICRLCDVLGVGLLTVQDIKVKNHPQFKNVAVTADRWMPMEEVALDEIASFMKEKKKEGYTLIGLEQTDKSVKLDNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVHSYTVQHM"},{"created_at":"2011-05-27T03:39:33.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"tRNA guanosine-2'-O-methyltransferase TRM13","uniprot_id":"Q12383","uniprot_name":"TRM13_YEAST","enzyme":true,"transporter":false,"gene_name":"TRM13","num_residues":476,"molecular_weight":"54094.5","theoretical_pi":"8.38","general_function":"Involved in methyltransferase activity","specific_function":"Specifically methylates guanosine-4 in various tRNAs with a Gly(CCG), His or Pro signature","reactions":[{"id":2733,"direction":"\u003e","locations":"Nucleus, nucleolus;Cytoplasm. Nucleus;Cytoplasm","altext":"S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U41293","genbank_protein_id":"1209716","gene_card_id":"TRM13","chromosome_location":"chromosome 15","locus":"YOL125W","synonyms":["tRNA [Gm4] methyltransferase","tRNA methylase 13"],"enzyme_classes":["2.1.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA processing"}],"pfams":[{"name":"TRM13","identifier":"PF05206"},{"name":"UPF0224","identifier":"PF05253"},{"name":"zf-TRM13_CCCH","identifier":"PF11722"}],"pathways":[],"gene_sequence":"ATGTTACAAGATAATAATGGGCCCGCTGTTAAGAGGGCGAAACCCTCAGAAAGGTTGCAATGTGAATATTTCATGGAAAAAAAGAAACGAAGATGTGGGATGACCAGGAGTTCTCAGAACTTGTATTGTTCAGAGCATCTGAATTTGATGAAAAAGGCGGCTAATTCTCAAGTGCATAATAAGAATGGCAGTGAAGCAGAGAAAGAAAGAGAAAGAGTACCTTGTCCGCTGGATCCTAACCATACGGTTTGGGCAGATCAATTAAAAAAGCATTTGAAAAAATGCAATAAGACCAAACTAAGCCATTTAAACGATGATAAGCCATACTATGAACCGGGCTATAACGGAGAGAATGGACTGTTATCGTCGTCTGTTAAAATAGATATTACTGCGGAACATTTGGTACAATCTATTGAATTGCTGTATAAGGTGTTTGAGGGAGAATCCATGGACGAGCTGCCTTTGAGACAACTGAACAATAAGCTTATGTCTCTAAAACGATTCCCTCAATTGCCTTCGAATACTAAACATGCTGTACAACAGTCTTCACTGATCGAAAACTTAGTGGACGCTGGCGCATTTGAGAGGCCAGAAAGTTTAAACTTCATTGAGTTTGGATGTGGCAGGGCCGAATTCTCGCGCTATGTCAGTCTGTACCTTTTAACACAATTGACAAGCCTTCCAGCGGAGCACTCGGGTTCAAACTCGAACGAGTTCGTGTTGATTGACAGAGCAACTAATAGGATGAAGTTCGATAAAAAGATAAAAGACGATTTTTCAGAAATAAAGTCAAACTCACCTTCCAAACCTATTAGCTGCCCCAGCATCAAAAGGATAAAGATCGACATTAGGGACTTGAAGATGGATCCGATTTTAAAATCGACACCTGGGGACGATATACAATACGTGTGCATCTCAAAACACCTTTGTGGTGTAGCTACAGATCTAACTTTGAGGTGTATAGGCAACAGCTCAATTTTACATGGCGACGATAACAACGGATGCAACCCCAAACTAAAGGCAATTTGTATTGCCATGTGCTGCAGGCATGTCTGTGACTACGGCGACTATGTCAACCGCAGTTACGTTACATCACTTGTTGAAAAGTATAGGGCCCATGGCTCCATCTTGACGTACGAAACCTTTTTCCGCGTTTTAACTAAACTCTGTTCATGGGGTACCTGCGGAAGGAAACCAGGTACGGCTATTACAGATATAGTAAACGTTGTCGAATCGTTTGAAGGGGCTGAGCCATATACAATAACCATTAAAGAGAGAGAAAATATTGGATTAATGGCTAGGCGTGTAATCGACGAGGGCAGGTTGGTATATGTGAAAGAAAAGTTTACAGAGTTTAATGCGGAGCTGATAAGGTACGTAGAATCCGATGTTTCTTTAGAGAACGTTGCTATGTTAGTTTATAAGAAATAG","protein_sequence":"MLQDNNGPAVKRAKPSERLQCEYFMEKKKRRCGMTRSSQNLYCSEHLNLMKKAANSQVHNKNGSEAEKERERVPCPLDPNHTVWADQLKKHLKKCNKTKLSHLNDDKPYYEPGYNGENGLLSSSVKIDITAEHLVQSIELLYKVFEGESMDELPLRQLNNKLMSLKRFPQLPSNTKHAVQQSSLIENLVDAGAFERPESLNFIEFGCGRAEFSRYVSLYLLTQLTSLPAEHSGSNSNEFVLIDRATNRMKFDKKIKDDFSEIKSNSPSKPISCPSIKRIKIDIRDLKMDPILKSTPGDDIQYVCISKHLCGVATDLTLRCIGNSSILHGDDNNGCNPKLKAICIAMCCRHVCDYGDYVNRSYVTSLVEKYRAHGSILTYETFFRVLTKLCSWGTCGRKPGTAITDIVNVVESFEGAEPYTITIKERENIGLMARRVIDEGRLVYVKEKFTEFNAELIRYVESDVSLENVAMLVYKK"},{"created_at":"2011-05-27T03:40:06.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Protein arginine N-methyltransferase HSL7","uniprot_id":"P38274","uniprot_name":"HSL7_YEAST","enzyme":true,"transporter":false,"gene_name":"HSL7","num_residues":827,"molecular_weight":"95152.5","theoretical_pi":"6.31","general_function":"Involved in methyltransferase activity","specific_function":"Involved in the control of the cell cycle at the G2/M (mitosis) transition. Cooperates with HSL1 to hyperphosphorylate SWE1, thereby targeting SWE1 for polyubiquitination and subsequent degradation. Acts as a negative regulator of the filamentous growth-signaling pathway through inhibition of STE20","reactions":[{"id":2737,"direction":"\u003e","locations":"Bud neck.","altext":"S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Bud neck.","genbank_gene_id":"U65920","genbank_protein_id":"1519245","gene_card_id":"HSL7","chromosome_location":"chromosome 2","locus":"YBR133C","synonyms":[],"enzyme_classes":["2.1.1.125"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PRMT5","identifier":"PF05185"}],"pathways":[{"name":"Stress-activated signalling pathways: high osmolarity test 1","kegg_map_id":null}],"gene_sequence":"ATGCATAGCAACGTATTTGTTGGTGTCAAACCAGGCTTTAATCATAAACAGCACAGCAAAAAGTCACGTTTCCTAGAAAATGTCTCTAGTCATTCACCAGAACTGCCTAGTAACTATGATTACGTTTTGCTTCCTATAACAACGCCAAGATATAAGGAAATAGTTGGGCAAGTTTTCAAAGATTTCCAAAGACAATCCATACAGAACTGGAAACCGCTTCAAATTCCTGAACCGCAGTTGCAGGATATCTGTATACCCCCGTTCAACGTCAAGAAGCTAGACAATGACGATACGCCGTCTTACATAGGGCTGTTATCCTCTTGGCTGGAGCTGGAGAGTCGCGATCCAAATGTAAGAGATCTTGGCTTAAAGGTCCTTCTAAACGAATGTAAGTACGCGAGGTTTGTTGGAATCAATAAGCTAATATTGGCGCCTCCACGGGACCTGTCCAACCTGCAATTGTATGGACAGATGATTTACAGGCTCCTGCAAAATCGCATCGTCTTTGCTGCGCCTGCGTTAACCATATCCATTTCTCTGCCACTTTACGAAGACAGCGATCCATTGGCCACTTGGGAACTGTGGAATACCGTGCGGAAACAATGCGAATATCATCCCTCTTTGACTATCTCTTTGGCTTTGCCAAGAACCAGGACTCCTTCGTATGTGCTGAATAGATGGTTAGCCGAACCCGTCTCGTGTCTTTTGGTATCTTCATCCATCTTTGCCAGTAATCAGTACGATTATCCCGTTTTACACAAGTTTAACCAGAATTTGATTTTAAAGTTCCAAAAGGTTAATGGAGATTCACAAATTTTGGGTAATGAATTATGCGTGATATTGCATGGGATGGAGAAATATGCCAATAATGTTAAGGGCGGAGAATCTGCCTATTTGGAATATATAAACTACTTATTGAAAAAGGGCGACAAAGTATTAAATTCCAATAGTAATCACCAATTTTTGCTCCAAGAGGACTCTCGGATAATGCCGCCTCTGAAACCTCATTCAGATAATTTATTAAATTCCACATATTTGACTTTTGAAAAAGATTTGGTGAAGTACGATCTTTACGAATCTGCCATATTAGAGGCGCTTCAAGATCTTGCTCCTCGAGCGAGTGCCAAGAGACCGTTGGTGATCCTAGTAGCCGGTGCGGGAAGAGGACCTTTAGTGGATCGAACTTTTAAGATAATATCAATGTTGTTTATGGATAGTAAGGTTTCTATAATTGCCATTGAAAAAAATCCACAGGCATATCTGTACTTGCAAAAAAGAAATTTCGACTGTTGGGATAATAGAGTGAAATTAATCAAGGAGGATATGACCAAATGGCAAATCAACGAGCCGTCGGAAAAGCGTATTCAGATAGATCTGTGCATAAGTGAACTGCTGGGTTCGTTCGGTTGCAATGAATTATCACCAGAATGTCTCTGGTCTATTGAAAAATATCATTCCCACAATGACACAATTTTCATACCGAGGTCATACTCTTCATACATAGCACCCATTTCGTCACCATTATTCTACCAAAAACTCTCACAAACAAATCGCTCTTTGGAGGCGCCCTGGATAGTCCATAGAGTGCCATACTGTATATTATCCTCAAGGGTAAATGAAGTGTGGCGGTTCGAGCATCCCATGGCCCAAAAAGATACTGTCCAAGACGAAGATGATTTTACAGTTGAATTTTCTCAAAGTTCATTAAATGAGTTCAAGATAAAGCACCGCGGCGAAATCCATGGCTTTATCGGATTCTTCTCGGCAAACTTATATAACAATATATTCTTGTCAACTTTGCCCAATGACAGCACAGTCCGTTTAAAATTTAGCGAAGAAACGTTGATGAATACCAGACGAGAAGAAAATCTAATCAAGAAATGTGACCATACACCAAATATGACCTCGTGGTCTCCAATTATCTTTCCTTTGAAGCAACCAATATCCTTTATAGATGACTCCGAACTTTCTGTGCTGATGTCTCGGATACACTCCGATACAGAACAAAAAGTTTGGTATGAATGGTCTTTGGAGAGTTTCATATACCTTATGTTGTCAAATTACACTTCGGCGGTAACTGCTGCAAGCATGACTATTCCGAGGTCTATAGTTACAGATGACACTAAAACTTTAGCCCATAATCGACATTATTCAGCGACTACCAATCAAAAGCTAGATAATCAAATTGATCTTGACCAAGACATTGAAAACGAAGAAGAACAGGGATTCCTATCCAATCTAGAAACTGGTTGGCAAAGCGTACAAGATATTCACGGACTCAGCGAAACCGCCAAACCGGACCATTTAGATTCTATCAATAAGCCTATGTTTGATCTCAAATCTACTAAAGCGCTTGAACCCTCTAACGAATTGCCAAGGCACGAAGACCTCGAGGAAGATGTTCCAGAAGTTCATGTCAGAGTCAAGACTAGTGTTTCCACGCTACATAATGTCTGTGGCAGAGCCTTTTCCCTGCCTCTGTGA","protein_sequence":"MHSNVFVGVKPGFNHKQHSKKSRFLENVSSHSPELPSNYDYVLLPITTPRYKEIVGQVFKDFQRQSIQNWKPLQIPEPQLQDICIPPFNVKKLDNDDTPSYIGLLSSWLELESRDPNVRDLGLKVLLNECKYARFVGINKLILAPPRDLSNLQLYGQMIYRLLQNRIVFAAPALTISISLPLYEDSDPLATWELWNTVRKQCEYHPSLTISLALPRTRTPSYVLNRWLAEPVSCLLVSSSIFASNQYDYPVLHKFNQNLILKFQKVNGDSQILGNELCVILHGMEKYANNVKGGESAYLEYINYLLKKGDKVLNSNSNHQFLLQEDSRIMPPLKPHSDNLLNSTYLTFEKDLVKYDLYESAILEALQDLAPRASAKRPLVILVAGAGRGPLVDRTFKIISMLFMDSKVSIIAIEKNPQAYLYLQKRNFDCWDNRVKLIKEDMTKWQINEPSEKRIQIDLCISELLGSFGCNELSPECLWSIEKYHSHNDTIFIPRSYSSYIAPISSPLFYQKLSQTNRSLEAPWIVHRVPYCILSSRVNEVWRFEHPMAQKDTVQDEDDFTVEFSQSSLNEFKIKHRGEIHGFIGFFSANLYNNIFLSTLPNDSTVRLKFSEETLMNTRREENLIKKCDHTPNMTSWSPIIFPLKQPISFIDDSELSVLMSRIHSDTEQKVWYEWSLESFIYLMLSNYTSAVTAASMTIPRSIVTDDTKTLAHNRHYSATTNQKLDNQIDLDQDIENEEEQGFLSNLETGWQSVQDIHGLSETAKPDHLDSINKPMFDLKSTKALEPSNELPRHEDLEEDVPEVHVRVKTSVSTLHNVCGRAFSLPL"},{"created_at":"2011-05-27T03:40:36.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Ribosomal 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rRNA methyltransferase SPB1","uniprot_id":"P25582","uniprot_name":"SPB1_YEAST","enzyme":true,"transporter":false,"gene_name":"SPB1","num_residues":841,"molecular_weight":"96484.0","theoretical_pi":"8.29","general_function":"Involved in methyltransferase activity","specific_function":"Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation. Methylates also the uridine in position 2921 in the absence of methylation of this residue guided by snoRNA snR52 at the stage of 35S pre-rRNA maturation","reactions":[{"id":2744,"direction":"\u003e","locations":"Nucleus, nucleolus","altext":"S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine.","export":false,"pw_reaction_id":null,"source":null},{"id":2733,"direction":"\u003e","locations":"Nucleus, nucleolus;Cytoplasm. Nucleus;Cytoplasm","altext":"S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus, nucleolus","genbank_gene_id":"X59720","genbank_protein_id":"1907120","gene_card_id":"SPB1","chromosome_location":"chromosome 3","locus":"YCL054W","synonyms":["2'-O-ribose RNA methyltransferase","S-adenosyl-L-methionine-dependent methyltransferase","Suppressor of PAB1 protein 1"],"enzyme_classes":["2.1.1.-"],"go_classes":[{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" nucleus"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleic acid binding"},{"category":"Process","description":" one-carbon metabolic process"},{"category":"Process","description":" methylation"},{"category":"Process","description":" rRNA metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" rRNA processing"},{"category":"Process","description":" rRNA modification"},{"category":"Process","description":" rRNA methylation"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"}],"pfams":[{"name":"FtsJ","identifier":"PF01728"},{"name":"Spb1_C","identifier":"PF07780"}],"pathways":[],"gene_sequence":"ATGGGTAAGACACAAAAGAAGAATAGTAAGGGACGTTTAGATAGATACTATTATCTAGCAAAGGAGAAAGGTTATCGTGCTCGTTCATCCTTTAAGATTATTCAGATTAATGAAAAGTATGGCCACTTCTTAGAAAAATCGAAGGTTGTTATTGATCTGTGTGCTGCTCCTGGTTCATGGTGTCAAGTTGCATCCAAACTCTGTCCTGTCAACTCCTTAATTATTGGTGTTGATATTGTTCCAATGAAGCCGATGCCCAATGTTATAACTTTTCAAAGTGATATTACAACAGAAGATTGTAGATCAAAATTGAGGGGTTATATGAAGACTTGGAAAGCTGATACAGTGTTGCATGATGGTGCTCCTAATGTTGGTTTGGGTTGGGTTCAGGATGCTTTCACCCAATCTCAATTAACCTTACAAGCTTTGAAGTTGGCCGTCGAAAATTTGGTGGTGAACGGTACTTTTGTTACTAAAATTTTCAGATCCAAGGATTATAATAAATTGATTTGGGTTTTCCAACAATTGTTTGAGAAAGTTGAAGCCACAAAACCACCCGCATCAAGAAATGTTTCTGCAGAAATTTTTGTAGTGTGTAAAGGTTTCAAGGCACCAAAGAGGCTGGACCCAAGATTACTGGATCCAAAAGAAGTTTTTGAAGAATTGCCAGATGGGCAACAGAATATGGAGTCCAAGATTTATAATCCCGAAAAAAAAGTTAGAAAAAGACAAGGTTATGAGGAAGGTGATAATTTACTGTATCATGAAACCTCAATTTTGGATTTTGTCAGGACGGAAGACCCAATAAGCATGCTTGGAGAAATGAATAAGTTTACAATTGATGAGAATGACCATGAATGGAAGATCTTGAAGAAATTGAAACAAACCACAGACGAGTTCCGTTCCTGTATTGAAGATTTAAAAGTCTTGGGTAAAAAGGATTTTAAAATGATCCTAAGATGGAGAAAGATTGCAAGGGAAATCTTGGGCATCGAAGTTAAGGACGACGCTAAAACAGAAATTGAAGTAGTACCGTTAACAGAAGAGGAGCAAATTGAAAAAGATTTGCAAGGTTTACAGGAGAAGCAGCGTCTAAATGTCAAGCGCGAAAGAAGAAGGAAGAACGAAATGAAGCAAAAGGAACTACAGAGAATGCAAATGAACATGATAACCCCCACTGATATTGGTATTGAAGCCGCAAGTTTGGGTAAAGAATCGTTGTTTAATTTGAAAACTGCAGAAAAGACTGGTATCTTGAACGACTTGGCGAAGGGTAAGAAAAGAATGATTTTTACAGACGATGAATTAGCCAAAGATAATGATATTTACATTGATGAAAACATCATGATCAAAGATAAGGATTCTGCCGCTGATGCGGACGATTTAGAAAGCGAGTTGAATGCCATGTATAGTGATTATAAAACTAGAAGGTCGGAAAGGGATGCCAAGTTTAGAGCTAAGCAAGCACGTGGTGGCGATAATGAGGAAGAATGGACCGGTTTTAATGAGGGAAGTCTAGAAAAGAAAGAAGAGGAAGGTAAAGATTATATCGAAGACAATGACGATGAAGGTGTCGAAGGAGACTCCGATGATGATGAAGCCATCACCAATTTGATTAGCAAATTGAAGGGACAAGAAGGTGATCACAAATTGAGTAGTAAGGCACGTATGATTTTCAATGATCCGATATTTAATAACGTTGAACCTGATTTGCCAGTAAATACCGTCAATGATGGCATAATGAGTTCCGAGTCTGTTGGTGATATTTCTAAATTAAATAAGAAAAGAAAACATGAAGAAATGCACCAGAAACAAGATGAAGCAGATTCTTCGGATGAGAGTTCAAGTGATGACTCCGATTTCGAAATTGTGGCCAACGATAATGCATCAGAAGAATTCGATTCTGATTATGATTCAGAGGAAGAAAAAAATCAAACAAAGAAAGAAAAGCATTCCAGAGACATTGATATTGCTACTGTTGAAGCCATGACTTTGGCACATCAGTTAGCATTGGGTCAGAAAAACAAGCATGATCTTGTTGATGAAGGTTTCAATAGATACACCTTCCGTGACACCGAAAATTTGCCAGATTGGTTTTTAGAAGATGAAAAGGAACATTCAAAGATAAATAAGCCGATTACTAAGGAGGCAGCGATGGCAATTAAAGAAAAAATAAAGGCAATGAACGCCCGTCCTATTAAGAAGGTTGCTGAAGCTAAGGCAAGAAAGAGGATGCGTGCCGTAGCTCGGTTAGAAAAGATCAAGAAGAAGGCGGGCTTGATTAACGATGATTCAGACAAGACAGAGAAGGACAAGGCTGAAGAAATTTCTAGATTGATGCGTAAGGTTACCAAAAAACCAAAGACCAAGCCAAAGGTTACTTTGGTTGTTGCCTCAGGTAGGAACAAAGGTTTGGCAGGTAGACCAAAGGGCGTTAAGGGTAAGTATAAGATGGTTGATGGTGTCATGAAGAATGAACAAAGAGCCCTAAGACGTATCGCAAAGAAGCATCACAAGAAAAAGTAG","protein_sequence":"MGKTQKKNSKGRLDRYYYLAKEKGYRARSSFKIIQINEKYGHFLEKSKVVIDLCAAPGSWCQVASKLCPVNSLIIGVDIVPMKPMPNVITFQSDITTEDCRSKLRGYMKTWKADTVLHDGAPNVGLGWVQDAFTQSQLTLQALKLAVENLVVNGTFVTKIFRSKDYNKLIWVFQQLFEKVEATKPPASRNVSAEIFVVCKGFKAPKRLDPRLLDPKEVFEELPDGQQNMESKIYNPEKKVRKRQGYEEGDNLLYHETSILDFVRTEDPISMLGEMNKFTIDENDHEWKILKKLKQTTDEFRSCIEDLKVLGKKDFKMILRWRKIAREILGIEVKDDAKTEIEVVPLTEEEQIEKDLQGLQEKQRLNVKRERRRKNEMKQKELQRMQMNMITPTDIGIEAASLGKESLFNLKTAEKTGILNDLAKGKKRMIFTDDELAKDNDIYIDENIMIKDKDSAADADDLESELNAMYSDYKTRRSERDAKFRAKQARGGDNEEEWTGFNEGSLEKKEEEGKDYIEDNDDEGVEGDSDDDEAITNLISKLKGQEGDHKLSSKARMIFNDPIFNNVEPDLPVNTVNDGIMSSESVGDISKLNKKRKHEEMHQKQDEADSSDESSSDDSDFEIVANDNASEEFDSDYDSEEEKNQTKKEKHSRDIDIATVEAMTLAHQLALGQKNKHDLVDEGFNRYTFRDTENLPDWFLEDEKEHSKINKPITKEAAMAIKEKIKAMNARPIKKVAEAKARKRMRAVARLEKIKKKAGLINDDSDKTEKDKAEEISRLMRKVTKKPKTKPKVTLVVASGRNKGLAGRPKGVKGKYKMVDGVMKNEQRALRRIAKKHHKKK"},{"created_at":"2011-05-27T03:48:01.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Sterol 24-C-methyltransferase","uniprot_id":"P25087","uniprot_name":"ERG6_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG6","num_residues":383,"molecular_weight":"43430.5","theoretical_pi":"5.52","general_function":"Involved in methyltransferase activity","specific_function":"Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol","reactions":[{"id":1957,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2745,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.","export":false,"pw_reaction_id":null,"source":null},{"id":14409,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006924","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X74249","genbank_protein_id":"396515","gene_card_id":"ERG6","chromosome_location":"chromosome 13","locus":"YML008C","synonyms":["Delta(24)-sterol C-methyltransferase"],"enzyme_classes":["2.1.1.41"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" steroid metabolic process"},{"category":"Process","description":" steroid biosynthetic process"}],"pfams":[{"name":"Methyltransf_11","identifier":"PF08241"},{"name":"Sterol_MT_C","identifier":"PF08498"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGAGTGAAACAGAATTGAGAAAAAGACAGGCCCAATTCACTAGGGAGTTACATGGTGATGATATTGGTAAAAAGACAGGTTTGAGTGCATTGATGTCGAAGAACAACTCTGCCCAAAAGGAAGCCGTTCAGAAGTACTTGAGAAATTGGGATGGTAGAACCGATAAAGATGCCGAAGAACGTCGTCTTGAGGATTATAATGAAGCCACACATTCCTACTATAACGTCGTTACAGATTTCTATGAATATGGTTGGGGTTCCTCTTTCCATTTCAGCAGATTTTATAAAGGTGAGAGTTTCGCTGCCTCGATAGCAAGACATGAACATTATTTAGCTTACAAGGCTGGTATTCAAAGAGGCGATTTAGTTCTCGACGTTGGTTGTGGTGTTGGGGGCCCAGCAAGAGAGATTGCAAGATTTACCGGTTGTAACGTCATCGGTCTAAACAATAACGATTACCAAATTGCCAAGGCAAAATATTACGCTAAAAAATACAATTTGAGTGACCAAATGGACTTTGTAAAGGGTGATTTCATGAAAATGGATTTCGAAGAAAACACTTTCGACAAAGTTTATGCAATTGAGGCCACATGTCACGCTCCAAAATTAGAAGGTGTATACAGCGAAATCTACAAGGTTTTGAAACCGGGTGGTACCTTTGCTGTTTACGAATGGGTAATGACTGATAAATATGACGAAAACAATCCTGAACATAGAAAGATCGCTTATGAAATTGAACTAGGTGATGGTATCCCAAAGATGTTCCATGTCGACGTGGCTAGGAAAGCATTGAAGAACTGTGGTTTCGAAGTCCTCGTTAGCGAAGACCTGGCGGACAATGATGATGAAATCCCTTGGTATTACCCATTAACTGGTGAGTGGAAGTACGTTCAAAACTTAGCTAATTTGGCCACATTTTTCAGAACTTCTTACTTGGGTAGACAATTTACTACAGCAATGGTTACTGTAATGGAAAAATTAGGTCTAGCCCCAGAAGGTTCCAAGGAAGTTACTGCTGCTCTAGAAAATGCTGCGGTTGGTTTAGTTGCCGGTGGTAAGTCCAAGTTATTCACTCCAATGATGCTTTTCGTCGCTAGGAAGCCAGAAAACGCCGAAACCCCCTCCCAAACTTCCCAAGAAGCAACTCAATAA","protein_sequence":"MSETELRKRQAQFTRELHGDDIGKKTGLSALMSKNNSAQKEAVQKYLRNWDGRTDKDAEERRLEDYNEATHSYYNVVTDFYEYGWGSSFHFSRFYKGESFAASIARHEHYLAYKAGIQRGDLVLDVGCGVGGPAREIARFTGCNVIGLNNNDYQIAKAKYYAKKYNLSDQMDFVKGDFMKMDFEENTFDKVYAIEATCHAPKLEGVYSEIYKVLKPGGTFAVYEWVMTDKYDENNPEHRKIAYEIELGDGIPKMFHVDVARKALKNCGFEVLVSEDLADNDDEIPWYYPLTGEWKYVQNLANLATFFRTSYLGRQFTTAMVTVMEKLGLAPEGSKEVTAALENAAVGLVAGGKSKLFTPMMLFVARKPENAETPSQTSQEATQ"},{"created_at":"2011-05-27T17:53:23.000Z","updated_at":"2011-05-29T05:06:52.000Z","name":"S-adenosylmethionine synthase 2","uniprot_id":"P19358","uniprot_name":"METK2_YEAST","enzyme":true,"transporter":false,"gene_name":"SAM2","num_residues":384,"molecular_weight":"42255.5","theoretical_pi":"4.98","general_function":"Coenzyme transport and metabolism","specific_function":"Catalyzes the formation of S-adenosylmethionine from methionine and ATP","reactions":[{"id":1728,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2580,"direction":"\u003e","locations":"","altext":"ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.","export":false,"pw_reaction_id":null,"source":null},{"id":3761,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006285","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M23368","genbank_protein_id":"295659","gene_card_id":"SAM2","chromosome_location":"chromosome 4","locus":"YDR502C","synonyms":["AdoMet synthase 2","Methionine adenosyltransferase 2","MAT 2"],"enzyme_classes":["2.5.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" methionine adenosyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" one-carbon metabolic process"}],"pfams":[{"name":"S-AdoMet_synt_C","identifier":"PF02773"},{"name":"S-AdoMet_synt_M","identifier":"PF02772"},{"name":"S-AdoMet_synt_N","identifier":"PF00438"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGTCCAAGAGCAAAACTTTCTTATTTACCTCTGAATCCGTCGGTGAAGGTCACCCAGACAAGATTTGTGACCAAGTTTCTGATGCTATTTTGGACGCTTGTTTAGAACAAGATCCATTCTCCAAGGTTGCCTGTGAAACAGCTGCCAAAACTGGTATGATTATGGTTTTCGGTGAAATTACCACCAAAGCTAGACTTGACTACCAACAAATAGTAAGAGATACCATCAAGAAGATTGGTTATGACGATTCTGCCAAGGGTTTCGACTACAAGACATGTAATGTTTTAGTAGCTATCGAACAACAATCTCCAGATATCGCTCAAGGTCTGCACTATGAAAAGAGCTTAGAAGACTTAGGTGCTGGTGACCAAGGTATAATGTTTGGTTACGCTACAGACGAAACTCCAGAAGGGTTACCATTGACCATTCTTTTGGCTCACAAATTGAACATGGCTATGGCAGATGCTAGAAGAGATGGTTCTCTCCCATGGTTGAGACCAGACACAAAGACTCAAGTCACTGTCGAATACGAAGACGACAATGGTAGATGGGTTCCAAAGAGGATAGATACCGTTGTTATTTCTGCTCAACATGCTGATGAAATTTCCACCGCTGACTTGAGAACTCAACTTCAAAAAGATATTGTTGAAAAGGTCATACCAAAGGATATGTTAGACGAAAATACCAAATATTTCATCCAACCATCCGGTAGATTCGTCATCGGTGGTCCTCAAGGTGACGCTGGTTTGACCGGTAGAAAGATTATTGTCGACGCTTACGGTGGTGCCTCATCCGTCGGTGGTGGTGCCTTCTCCGGTAAGGACTATTCCAAGGTCGATCGTTCCGCTGCTTACGCTGCTAGATGGGTTGCCAAGTCTCTAGTTGCCGCTGGTTTGTGTAAGAGAGTCCAAGTCCAATTTTCATATGCTATTGGTATTGCTGAACCATTGTCTTTACATGTGGACACCTATGGTACAGCTACAAAATCAGATGACGAAATCATTGAAATTATTAAGAAGAACTTCGACTTGAGACCAGGTGTGTTAGTAAAGGAATTAGATTTGGCTAGACCAATTTACTTACCAACCGCTTCTTATGGTCACTTCACTAATCAAGAGTACTCATGGGAAAAACCAAAGAAATTGGAATTTTAA","protein_sequence":"MSKSKTFLFTSESVGEGHPDKICDQVSDAILDACLEQDPFSKVACETAAKTGMIMVFGEITTKARLDYQQIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGLHYEKSLEDLGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLPWLRPDTKTQVTVEYEDDNGRWVPKRIDTVVISAQHADEISTADLRTQLQKDIVEKVIPKDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDDEIIEIIKKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYSWEKPKKLEF"},{"created_at":"2011-05-29T04:49:56.000Z","updated_at":"2011-05-29T05:06:53.000Z","name":"tRNA (uracil-5-)-methyltransferase","uniprot_id":"P33753","uniprot_name":"TRM2_YEAST","enzyme":true,"transporter":false,"gene_name":"TRM2","num_residues":639,"molecular_weight":"72851.79688","theoretical_pi":"9.14","general_function":"Involved in RNA methyltransferase activity","specific_function":"Catalyzes the formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNA. May also have a role in tRNA stabilization or maturation","reactions":[{"id":2849,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine + tRNA containing uridine at position 54 = S-adenosyl-L-homocysteine + tRNA containing ribothymidine at position 54.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"TRM2","chromosome_location":"chromosome 11","locus":"YKR056W","synonyms":["Transfer RNA methyltransferase 2","tRNA(M-5-U54)-methyltransferase"],"enzyme_classes":["2.1.1.35"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" RNA methyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" RNA processing"}],"pfams":[{"name":"TRAM","identifier":"PF01938"},{"name":"tRNA_U5-meth_tr","identifier":"PF05958"}],"pathways":[],"gene_sequence":"ATGTACGAACAGTTTGAATTTTCTTTTTTTTTCTTCGAAAATTCAGACAATAAGGTTAAATATAAAGCTCATCTCATCTCATCGATAAAACGCTGGAGTATTATCACATGCATGCGTTGCTTTTGGACCGTACAGAAGTCTATATTTAAAGCTAGGTTTTTCGCTTGCAGAAACTTTGTCAAGAAGCATAATTATAAACTAATCAGCACCATGACTGGAAGTACTGAAATGGTACCACCAACAATGAAACATACCGTTGACAACAAAAGGCTTTCGTCTCCTTTGACAGATTCTGGTAACCGCCGGACTAAGAAGCCAAAGTTGAGAAAGTACAAGGCCAAAAAGGTTGAAACAACTTCTCCGATGGGTGTCCTAGAATTTGAAGTGAACGATTTGTTAAAATCTCAAAATTTGTCCAGGGAGCAGGTTCTGAACGATGTTACTTCAATTCTAAATGATAAGTCCTCAACAGATGGACCTATCGTCTTACAATATCACCGAGAGGTAAAAAATGTCAAGGTCTTAGAAATTACTTCCAATGGCAACGGGTTGGCTTTGATCGATAATCCTGTTGAAACAGAAAAGAAGCAAGTTGTTATCATACCGTTTGGCCTGCCCGGTGATGTAGTTAATATCAAAGTCTTTAAGACCCACCCTTACTATGTCGAGAGTGATTTATTAGACGTAGTGGAAAAATCTCCAATGAGAAGAGATGATTTAATTAGGGATAAATATTTCGGGAAATCTTCAGGAAGTCAATTAGAGTTCTTAACTTACGATGACCAACTAGAATTGAAAAGAAAAACAATTATGAATGCCTACAAGTTCTTCGCACCAAGGTTAGTTGCTGAAAAACTTTTACCCCCATTTGACACCACCGTAGCTTCCCCTTTACAATTTGGCTACAGGACCAAAATTACGCCTCATTTCGATATGCCAAAAAGAAAACAAAAGGAACTATCAGTAAGGCCTCCTTTAGGATTTGGTCAAAAGGGTAGACCTCAATGGAGAAAAGATACTTTGGATATCGGCGGACATGGTTCGATATTAGATATCGATGAATGTGTGCTTGCAACTGAAGTTCTCAACAAAGGATTGACTAATGAAAGAAGAAAGTTTGAGCAAGAGTTTAAAAACTACAAAAAAGGCGCGACTATTTTACTGAGAGAGAATACCACTATTTTAGACCCTTCCAAACCAACTTTAGAACAGTTAACCGAAGAAGCCTCTAGGGATGAAAATGGTGATATAAGTTATGTCGAAGTCGAAGACAAAAAGAACAATGTCAGGCTGGCTAAAACTTGCGTTACCAATCCTAGACAAATTGTCACTGAATATGTTGATGGATATACTTTTAATTTTAGTGCGGGTGAGTTTTTTCAAAATAATAACTCTATCCTGCCAATAGTGACCAAGTATGTCCGTGATAACTTGCAAGCTCCCGCTAAAGGTGATGATAATAAAACAAAGTTTCTAGTAGATGCTTATTGTGGATCAGGTCTTTTCAGTATATGCAGCTCCAAGGGCGTAGATAAAGTGATTGGTGTAGAAATTTCCGCTGACAGTGTCTCTTTTGCAGAAAAAAATGCAAAGGCAAATGGTGTTGAAAACTGTAGATTCATCGTTGGAAAGGCTGAGAAACTCTTTGAGTCTATTGATACTCCAAGTGAAAACACTTCCGTTATCTTGGATCCACCACGCAAGGGCTGTGACGAATTATTCCTAAAGCAATTAGCCGCATATAATCCAGCCAAGATTATTTACATATCGTGTAATGTCCATTCCCAGGCACGTGATGTCGAGTACTTCCTCAAAGAAACAGAAAACGGTTCCGCCCACCAGATTGAAAGCATAAGAGGATTTGATTTCTTTCCACAAACGCACCACGTTGAGAGTGTGTGTATAATGAAGAGAATCTAA","protein_sequence":"MYEQFEFSFFFFENSDNKVKYKAHLISSIKRWSIITCMRCFWTVQKSIFKARFFACRNFVKKHNYKLISTMTGSTEMVPPTMKHTVDNKRLSSPLTDSGNRRTKKPKLRKYKAKKVETTSPMGVLEFEVNDLLKSQNLSREQVLNDVTSILNDKSSTDGPIVLQYHREVKNVKVLEITSNGNGLALIDNPVETEKKQVVIIPFGLPGDVVNIKVFKTHPYYVESDLLDVVEKSPMRRDDLIRDKYFGKSSGSQLEFLTYDDQLELKRKTIMNAYKFFAPRLVAEKLLPPFDTTVASPLQFGYRTKITPHFDMPKRKQKELSVRPPLGFGQKGRPQWRKDTLDIGGHGSILDIDECVLATEVLNKGLTNERRKFEQEFKNYKKGATILLRENTTILDPSKPTLEQLTEEASRDENGDISYVEVEDKKNNVRLAKTCVTNPRQIVTEYVDGYTFNFSAGEFFQNNNSILPIVTKYVRDNLQAPAKGDDNKTKFLVDAYCGSGLFSICSSKGVDKVIGVEISADSVSFAEKNAKANGVENCRFIVGKAEKLFESIDTPSENTSVILDPPRKGCDELFLKQLAAYNPAKIIYISCNVHSQARDVEYFLKETENGSAHQIESIRGFDFFPQTHHVESVCIMKRI"}]}