{"ymdb_id":"YMDB00291","created_at":"2011-05-29T18:02:46.000Z","updated_at":"2016-09-08T18:35:18.000Z","name":"Inositol 1,4,5-trisphosphate","cas":"88269-39-0","state":"Solid","melting_point":"","description":"Inositol 1,4,5-trisphosphate is an intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"nucleus","synthesis_reference":"Cooke, Allan M.; Potter, Barry V. L.; Gigg, Roy. Synthesis of DL-myo-inositol 1,4,5-trisphosphate. Tetrahedron Letters (1987), 28(20), 2305-8.","chebi_id":"16595","hmdb_id":"HMDB01498","kegg_id":"C01245","pubchem_id":"439456","cs_id":"23097104","foodb_id":null,"wikipedia_link":"Inositol 1,4,5-trisphosphate","biocyc_id":"inositol_1,4,5-trisphosphate","iupac":"{[(1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4,6-bis(phosphonooxy)cyclohexyl]oxy}phosphonic acid","traditional_iupac":"InsP3","logp":"-4.152707746","pka":"1.036823557327442","alogps_solubility":"1.48e+01 g/l","alogps_logp":"-0.86","alogps_logs":"-1.45","acceptor_count":"12","donor_count":"9","rotatable_bond_count":"6","polar_surface_area":"260.96999999999997","refractivity":"68.3937","polarizability":"29.607530919943862","formal_charge":"0","physiological_charge":"-6","pka_strongest_basic":"-3.6688996734755257","pka_strongest_acidic":"0.5363206524866495","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["1D-myo-Inositol 1,4,5-trisphosphate","D-myo-Inositol 1,4,5-trisphosphate","Inositol 1,4,5-trisphosphate","Inositol 1,4,5-trisphosphic acid"],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":11956213,"citation":"Dubois, E., Scherens, B., Vierendeels, F., Ho, M. M., Messenguy, F., Shears, S. B. (2002). \"In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis.\" J Biol Chem 277:23755-23763."},{"pubmed_id":8395015,"citation":"Flick, J. S., Thorner, J. (1993). \"Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae.\" Mol Cell Biol 13:5861-5876."}],"proteins":[{"created_at":"2011-05-24T19:50:13.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Inositol polyphosphate multikinase","uniprot_id":"P07250","uniprot_name":"IPMK_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG82","num_residues":355,"molecular_weight":"40352.5","theoretical_pi":"4.33","general_function":"Involved in inositol trisphosphate 3-kinase activity","specific_function":"Has kinase activity and phosphorylates inositol-1,4,5- trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. Originally it was proposed that the ARGRI and ARGRIII proteins are more likely to be involved in the control of ARGRII activity","reactions":[{"id":1661,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1662,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1663,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1664,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2276,"direction":"\u003e","locations":null,"altext":"ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2277,"direction":"\u003e","locations":null,"altext":"ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14818,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007006","source":"Smpdb"},{"id":14819,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007031","source":"Smpdb"},{"id":14820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007032","source":"Smpdb"},{"id":14821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007033","source":"Smpdb"},{"id":14822,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007034","source":"Smpdb"},{"id":14823,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007035","source":"Smpdb"},{"id":14824,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007036","source":"Smpdb"},{"id":14825,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007037","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X05328","genbank_protein_id":"3376","gene_card_id":"ARG82","chromosome_location":"chromosome 4","locus":"YDR173C","synonyms":["IPMK","Arginine metabolism regulation protein III"],"enzyme_classes":["2.7.1.151"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" inositol trisphosphate kinase activity"},{"category":"Function","description":" inositol trisphosphate 3-kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IPK","identifier":"PF03770"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"}],"gene_sequence":"ATGGATACGGTAAACAATTATAGGGTTTTAGAGCATAAAGCTGCTGGCCACGACGGTACTCTAACAGACGGTGATGGATTGCTCATCTTTAAACCGGCCTTTCCGCAGGAACTGGAATTCTACAAAGCCATACAAGTGAGAGATGTGAGTCGAAGAAAGTCTTCGGCTGATGGAGATGCTCCCTTGTGCTCTTGGATGCCCACGTATCTTGGAGTCTTGAATGAAGGGGCAAAAATCGAGCAAAGTGGCGATGCTGCGCTTCTGAAGATAGATGAGCGGTTAAGTGATTCCACTGATAATCTTGATTCAATACCTGTAAAGTCTGAGAAGTCCAAGCAATACCTCGTTTTAGAAAATCTACTATATGGATTTAGTAAACCTAATATACTTGATATAAAATTAGGCAAAACTTTGTATGATTCGAAGGCATCATTGGAAAAAAGAGAGAGAATGAAAAGAGTCAGTGAGACGACGACTTCAGGATCTTTGGGTTTCAGGATATGTGGCATGAAAATACAGAAAAATCCCTCTGTGCTGAATCAGCTTTCGCTCGAATATTACGAAGAAGAAGCAGACAGTGATTATATCTTTATAAACAAATTGTATGGTCGTTCAAGAACCGATCAAAATGTTTCAGATGCAATTGAACTTTATTTTAACAATCCTCATCTGTCGGATGCGAGAAAGCATCAACTGAAGAAAACATTTTTGAAAAGATTGCAGTTGTTTTATAATACTATGCTAGAAGAAGAAGTTAGAATGATATCAAGTAGTCTTTTGTTTATTTACGAAGGAGACCCGGAGCGATGGGAATTACTAAATGATGTTGACAAACTTATGCGAGATGATTTTATAGACGATGATGACGACGATGATGATAATGATGATGATGATGATGATGATGCCGAGGGAAGCAGCGAAGGACCAAAGGACAAAAAAACAACTGGTTCTTTGAGTTCCATGTCACTAATAGATTTTGCACATTCTGAAATAACGCCGGGGAAGGGTTATGATGAAAACGTGATTGAAGGAGTTGAAACCTTGCTAGATATTTTTATGAAATTCTAG","protein_sequence":"MDTVNNYRVLEHKAAGHDGTLTDGDGLLIFKPAFPQELEFYKAIQVRDVSRRKSSADGDAPLCSWMPTYLGVLNEGAKIEQSGDAALLKIDERLSDSTDNLDSIPVKSEKSKQYLVLENLLYGFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKIQKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNPHLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWELLNDVDKLMRDDFIDDDDDDDDNDDDDDDDAEGSSEGPKDKKTTGSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIFMKF"},{"created_at":"2011-05-27T06:28:05.000Z","updated_at":"2011-05-27T15:01:26.000Z","name":"1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase 1","uniprot_id":"P32383","uniprot_name":"PLC1_YEAST","enzyme":true,"transporter":false,"gene_name":"PLC1","num_residues":869,"molecular_weight":"100547.0","theoretical_pi":"9.55","general_function":"Involved in protein binding","specific_function":"The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for cell growth, osmoresistance and expression of GPD1","reactions":[{"id":1872,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2787,"direction":"\u003e","locations":"Cytoplasmic","altext":"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.","export":false,"pw_reaction_id":null,"source":null},{"id":14855,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007043","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"D12738","genbank_protein_id":"287612","gene_card_id":"PLC1","chromosome_location":"chromosome 16","locus":"YPL268W","synonyms":["Phosphoinositide phospholipase C","Phospholipase C-1","PLC-1"],"enzyme_classes":["3.1.4.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" lipase activity"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" phospholipase activity"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" phospholipase C activity"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" phosphoric diester hydrolase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" phosphoinositide phospholipase C activity"},{"category":"Function","description":" calcium ion binding"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" intracellular signaling pathway"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"},{"category":"Process","description":" signaling"}],"pfams":[{"name":"PI-PLC-X","identifier":"PF00388"},{"name":"PI-PLC-Y","identifier":"PF00387"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTGAAAGTGCTATAGATGACCAAAGGTTTAATCTTACAAAGGAGTTACAACGACACTCATGCAGAGATCAAGGGAAAATAACACAAAAGGATGATGCTTTAGATTTTATAAGTTACAGTTCTTTTCAATCCTCTTTTAATACTGACCAAAAAAGCGCGAACAATGGAAGTACTGTGAGAAGAAGCATAAGGTCGATTTTTAGAAGAGCAGCCGAATTGCCTAGAGTCCATATGGGGCCTCTTACTTATTCACATGGGATAAATGAGCTTGTTAACAAGAAATTAAGAAAAGACTGTGATCTCAGCACGCTATGTCGCGTATTGCAAAGAGGAATCAGGATGATTAGGATGACAAGAAGAAGAAGGAAGTTCTATGAATTTAAATTAATCAATAACAACGGGCAAATAATATGGAAAGATGGTTCGAAGTATCTGGAATTAGACTCCGTTAAAGACATCAGAATCGGTGATACGGCGAGTACTTATCAAGAGGAAGTAGATCCGAAAAGATTGAGATCGGACAGTAAACTTTGGATTGCTATTATTTATAAGGTTTCCAACAAATTGAAAGCGTTACACGTAGTTGCTTTGAATGAATTGGACTTTAACACATTCTTAAGCTGCATTTGCGGTTTAGTGAAGTTAAGGAGGGAATTAATGGAAAGCATACTTTTGCCTGATAATTCGCAATTCGCTAGGATACATTGGCAAATTACTGTTTCTGAAAAAGAGGAAGATGAGAAAAAGGACACATTGAGCTTTGCAGATGTGAAGAAACTATGTGATAAATTTCATATTTATGTGTCAACTGGTCAATTGTTAGAGTTTTTCCAATTAGCAGACATCAATCATAACGGACTATTAAATTATTTTGAATTTGAAAAGTTCATTAAAATCTTAAAGAATAGGAAAGAGGTAAATATGATTTGGTCTAAATTTACAAAACCTCCACACTCCCACTTATCATTTGAAAATTTTTTTCAATTTTTAATTACAGAGCAGCATGAGCAAGTGGATCGTCAAACTGCATGGTCATATTTTATTAAGTACAGAGAACCGACTCAGCTGACGATGGGGCAAGATGGTTTTACCAAGTTCTTGAAGGAGCAACCATATTTGGTGGAGGTTAAAGAGGAGTTATATTCAAAGCCATTAAACCATTATTTTATTGCATCTTCACATAATACTTATTTATTGGGGAAACAAATTGCAGAAACTCCATCTGTGGAGGGATATATTCAAGTCCTACAACAAGGTTGTAGGTGCGTAGAAATTGATATATGGGATGGTGAAAATGGGCCAGTGGTATGCCATGGATTTTTAACGTCAGCTATTCCCTTAAAAACAGTTATACGCGTGATAAAGAAGTACGCTTTTATAACGTCTCCGTATCCTTTGATTATTTCACTGGAAATAAACTGTAACAAGGATAATCAAAAATTGGCAAGCCTGATAATGAGAGAGGTTTTAGCAGAACAGCTGTACTTTGTTGGCACAAGAACTGATAAACTGCCATCACCAAGGGAATTAAAACATAAAATACTGTTGAAATCCAAGAAGACGAGTGAAGCAACTAGAGGTCTTAGCGTTAATGAGCCATTTCCATCTTCTTTTAGTTCTTCTTACGAATCAGCTAATGAACAGGAATTAAGAATGAAAGATGACTCCACGAACAGTAGTAGCGCAACAAATTCTTCTAGTATGCAACGCATCAAAAGAATTGGATTAAAAAAGCACGCTGATATAATTAATGATGTTTCTAACATTTCTGGAATACATGGCATCAAGTTCAGGAATTTCTCTTTACCAGAGTCCAAAACGATAGCGCATTGTTTTTCACTGAATGAGCGCAAAGTAGAATACATGATAAAAGACAAACACTTAAAATTATCGTTGGATAAACATAATAGAAGATATTTGATGAGAGTCTATCCTCACGTTTTACGATACAAATCATCAAATTTTAACCCAATACCTTTTTGGAAGGCCGGTGTACAAATGGTGGCTACGAATTGGCAAACTAATGATATTGGACAGCAACTTAATCTGGCAATGTTTCAAATATTAGATCACCAACCTGATGGAAGTTTTAAATCAGGATACGTGCTAAAACCAAAAAAGTTGCTACCTGTAGTAACAAAGGCGAAAATGATTCCATTAATTTACGAACATTTTGAAAATGGTAGTGATCCTGTTACTGTTAAAATTCGAATTTTATCTACACAGTTATTGCCCAGATTGAATGATACATCGCCAAGCAGAAATAACACCAATTCCTTTGTTAAAGTGGAGTTTCATACCGATGACGAGCCGACAATGCCCATCTCAATCGATAAGGGTACAAGGATTTCTGCCACTGAAGCATCCACTAAGAGTTCTCAAGGGAATGGATTCAACCCAATATGGGATGCTGAAGTTTCTATCACATTGAAAGATACAGACCTCACATTTATAAAATTCATGGTTATCTCTGAAGAGACCCAGATTGCATCTGTTTGCCTTAAGCTGAACTATTTGAGGATGGGATATCGTCACATTCCGTTGTTTAACATGGAGGGGGAACAATACATATTTTGCACTTTATTTATTCATACACAAATTTTATAG","protein_sequence":"MTESAIDDQRFNLTKELQRHSCRDQGKITQKDDALDFISYSSFQSSFNTDQKSANNGSTVRRSIRSIFRRAAELPRVHMGPLTYSHGINELVNKKLRKDCDLSTLCRVLQRGIRMIRMTRRRRKFYEFKLINNNGQIIWKDGSKYLELDSVKDIRIGDTASTYQEEVDPKRLRSDSKLWIAIIYKVSNKLKALHVVALNELDFNTFLSCICGLVKLRRELMESILLPDNSQFARIHWQITVSEKEEDEKKDTLSFADVKKLCDKFHIYVSTGQLLEFFQLADINHNGLLNYFEFEKFIKILKNRKEVNMIWSKFTKPPHSHLSFENFFQFLITEQHEQVDRQTAWSYFIKYREPTQLTMGQDGFTKFLKEQPYLVEVKEELYSKPLNHYFIASSHNTYLLGKQIAETPSVEGYIQVLQQGCRCVEIDIWDGENGPVVCHGFLTSAIPLKTVIRVIKKYAFITSPYPLIISLEINCNKDNQKLASLIMREVLAEQLYFVGTRTDKLPSPRELKHKILLKSKKTSEATRGLSVNEPFPSSFSSSYESANEQELRMKDDSTNSSSATNSSSMQRIKRIGLKKHADIINDVSNISGIHGIKFRNFSLPESKTIAHCFSLNERKVEYMIKDKHLKLSLDKHNRRYLMRVYPHVLRYKSSNFNPIPFWKAGVQMVATNWQTNDIGQQLNLAMFQILDHQPDGSFKSGYVLKPKKLLPVVTKAKMIPLIYEHFENGSDPVTVKIRILSTQLLPRLNDTSPSRNNTNSFVKVEFHTDDEPTMPISIDKGTRISATEASTKSSQGNGFNPIWDAEVSITLKDTDLTFIKFMVISEETQIASVCLKLNYLRMGYRHIPLFNMEGEQYIFCTLFIHTQIL"},{"created_at":"2011-05-27T06:28:57.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Inositol-1,4,5-trisphosphate 5-phosphatase 3","uniprot_id":"Q12271","uniprot_name":"INP53_YEAST","enzyme":true,"transporter":false,"gene_name":"INP53","num_residues":1107,"molecular_weight":"124576.0","theoretical_pi":"7.2","general_function":"Involved in inositol or phosphatidylinositol phosphatase activity","specific_function":"Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN","reactions":[{"id":1845,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;vacuole;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1846,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1847,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1848,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1851,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1904,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2788,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch; Cytoplasmic side;Endoplasmic reticulum membrane; Peripheral membrane protein","altext":"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2789,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch","altext":"D-myo-inositol 1,4,5-trisphosphate + H2O = D-myo-inositol 1,4-bisphosphate + phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":2790,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch","altext":"D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = D-myo-inositol 1,3,4-trisphosphate + phosphate","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm.","genbank_gene_id":"X94335","genbank_protein_id":"1164954","gene_card_id":"INP53","chromosome_location":"chromosome 15","locus":"YOR109W","synonyms":["Suppressor of PMA1 protein 2","Synaptojanin-like protein 3"],"enzyme_classes":["3.1.3.36","3.1.3.56"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Exo_endo_phos","identifier":"PF03372"},{"name":"Syja_N","identifier":"PF02383"}],"pathways":[{"name":"Inositol phosphate 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Specifically functions within the early endocytic pathway and actin organization","reactions":[{"id":1845,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;vacuole;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1846,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1847,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1848,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1851,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell 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phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":14856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007044","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm, cytoskeleton, actin patch","genbank_gene_id":"Z71382","genbank_protein_id":"1302022","gene_card_id":"INP52","chromosome_location":"chromosome 14","locus":"YNL106C","synonyms":["Synaptojanin-like protein 2"],"enzyme_classes":["3.1.3.36","3.1.3.56"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase 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Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth","reactions":[{"id":1847,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1848,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2788,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch; Cytoplasmic side;Endoplasmic reticulum membrane; Peripheral membrane protein","altext":"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14838,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007015","source":"Smpdb"},{"id":14839,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007021","source":"Smpdb"},{"id":14840,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007039","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm, cytoskeleton, actin patch","genbank_gene_id":"Z38062","genbank_protein_id":"557848","gene_card_id":"INP51","chromosome_location":"chromosome 9","locus":"YIL002C","synonyms":["Synaptojanin-like protein 1"],"enzyme_classes":["3.1.3.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Exo_endo_phos","identifier":"PF03372"},{"name":"Syja_N","identifier":"PF02383"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGAGACTCTTCATCGGTAGAAGATCACGGTCGATTGTAATATCTTCCAACAACTACTGTTTATCCTTCCAGCGTTTGCGCAGCATACCAGGTGCCAGTTCTCAGCAGCGTCAATTAAGTAAAACTCCTAGCGTAACAATCAAGTCCTACCCTGACACAGATCTTTCAAGTGATAGTAACTATCTCGAAGTCAAAAGTTGCATATTTAATGGATTATTAGGGCTCGTTTGTCTTAATGGTGATATATATGTTGCCGTCATATCTGGTGTTCAGAATGTTGGGTTTCCTCGATGGAAACTGATAGATCATCAAGTTAGGCCTTCGGAGAGCATTTATAAAGTATTGGATGTTGACTTTTACAGCTTAGAAAATGATGTTTTCGACTACCTCCTCTGCGAGAGATCAGAGCAAAACTATGATAAATTGATTCATGAGCATCCTTGCGGCCCCCTGAAAAAACTGTTTAGTGATGGAACATTCTACTATTCTAGAGATTTCGACATCTCTAATATCGTGAAAAACCATGGTTTATCACATAACTTAGAATATACCGTAGATAATCAAGATTTATCATTTATTTGGAATGCTAACTTAGCAAGTGAGGTAATCAACTGGAGAAGCAAGATTTCAAATGAGGAGAAACAACTTTTTGCCAACGCAGGGTTCTTAACATTTGTAATTCGGGGTTATTGCAAGACAGCATTAATAGAAGACGGCCCAAATACAGCCTCTATAACCATTATTTCCAGAATTTCGACTGAGAGCAAGCAGGATACGCTAGAATTGGAGGGTATTAGTGAAGATGGGAGAGTGTCGCTATTTGTTGAGACAGAAATTGTAGTAACCACAGAAAAGTTTATTTTTTCTTATACTCAAGTGAACGGAAGCATTCCTCTTTTTTGGGAATCTGTAGAAAGTCAACTGTTGTATGGAAAAAAAATTAAGGTAACAAAAGATTCTATTGAAGCTCAGGGAGCTTTTGACAGGCATTTTGATAATTTAACCTCAAAGTATGGTGTTGTGAGTATCGTTAATATCATAAAACCTAAAAGCGAATCACAAGAAAAGTTAGCACTGACGTACAAGGATTGTGCTGAATCAAAGGGAATAAAAATAACAAATATAGAATACAGCTCAAGCGTTCTGACAAAGTCTCCCCACAAATTACTTTATTTATTAAAACAGGATATTTACGAGTTTGGAGCGTTTGCCTATGATATCTCTAGGGGCATCTACTTTGCAAAACAAACGGGGGTATTAAGAATAAGCGCATTTGATTCAATTGAAAAACCTAACACAGTTGAAAGGTTAGTGAGCAAGGAGGTACTTGAATTAACCACAAATGAAATTGATGTATTTGAATTGACTTCCCCATTCTTGGACGCACATGATAAGCTATGGTCAGAAAACTATTACTGGCTTGATCGAACGTATACTAAGCACACGAAGAATTCTGGTAAATATACAAAGGTTTATTCGAAGTTATTTGGTTCCCGAGTTAGATTATACGACCCGCTCCATATCTACATCTCTCAGTATTTAAAGCAATTAAGGTCAAAATATACGTTTGAGAAAGACATCTCAATTTTTGCAGGTACATTTAATATAAGTGGTAAAATTCCAAAAGATGATATAAAAGATTGGATATTTCCAAAATCAATGTCCAAGGAGGATGAAATGGCTGATCTTTATGTTATCGGATTAGAAGAAGTGGTAGAACTTACCCCAGGTCATATGCTTGCTACCGATCCATATGTCCGACAATTTTGGGAGAAGAAGATATTAACACTATTAAATGGGCCCGGACGCAAAAAAAAATATATCCGTTTATGGAGTACACAGTTGGGTGGTATTTTACTATTATTATTCATGAATGAAACGGAATATTCCAAGGTAAAGCATATTGAGGGGGATGTTAAAAAAACCGGGTTTGGAGGAATGGCTTCTAATAAAGGAGCTGTCGCGGTTAGTTTTAAATACTCAGCTACAAGATTTTGCGTACTAGTATCTCATTTAGCGGCAGGCTTAGAAAATGTTGAACAAAGGCATAATGATTATAAGACGATTGCGAAAAGCATACGATTTTCTAAAGGATTACGAATAAAGGATCACGATGCAATTATTTGGATGGGCGATTTCAATTACAGAATATTGATGTCAAACGAAGATGTTAGACGAAAAATTGTTTCTAAAGAATATGCCAGCCTATTTGAAAAGGATCAACTTAATCAACAAATGATCGCAGGTGAGTCTTTTCCATATTTCCATGAAATGGCGATTGATTTCCCACCTACCTATAAATTCGACCCAGGAACTAAAAACTACGACACGAGCGAAAAAATGAGAATACCAGCATGGACTGATAGGATTTTAAGTAGGGGAGAAGTACTAGAACAGTTAGAATATAAATGCTGTGAAGATATACTATTTTCCGATCATCGGCCCGTATATGCCATATTTAGGGCTAGAGTGACTGTAGTGGATGAACAAAAAAAGACTACTTTGGGTACGCAAATCTACGAGAAGATTATGGAAAGGCTAGAGGGATTGGATGATGATGAGAAAATTGCAGTTTTGAGTGATGATGCATTTGTTATCGAAAGTTTTGAGGGCAGTGATTCGATAGCTGGCCCTACGCATTCTCCGACACCAATTCCCGAGCCCAAAAGAGGTAGAAAGTTACCACCACCTAGTTCGGATTTAAAAAAATGGTGGATTGGAAGTGGGAAGCAAGTTAAAGTAGTTCTTGACGTAGACCCGGCCGTTTACATGATTAATCCTAAAAGAGATCCCAATCCATTCGTTGAGAACGAAGATGAGCCACTTTTTATAGAAAGGTAA","protein_sequence":"MRLFIGRRSRSIVISSNNYCLSFQRLRSIPGASSQQRQLSKTPSVTIKSYPDTDLSSDSNYLEVKSCIFNGLLGLVCLNGDIYVAVISGVQNVGFPRWKLIDHQVRPSESIYKVLDVDFYSLENDVFDYLLCERSEQNYDKLIHEHPCGPLKKLFSDGTFYYSRDFDISNIVKNHGLSHNLEYTVDNQDLSFIWNANLASEVINWRSKISNEEKQLFANAGFLTFVIRGYCKTALIEDGPNTASITIISRISTESKQDTLELEGISEDGRVSLFVETEIVVTTEKFIFSYTQVNGSIPLFWESVESQLLYGKKIKVTKDSIEAQGAFDRHFDNLTSKYGVVSIVNIIKPKSESQEKLALTYKDCAESKGIKITNIEYSSSVLTKSPHKLLYLLKQDIYEFGAFAYDISRGIYFAKQTGVLRISAFDSIEKPNTVERLVSKEVLELTTNEIDVFELTSPFLDAHDKLWSENYYWLDRTYTKHTKNSGKYTKVYSKLFGSRVRLYDPLHIYISQYLKQLRSKYTFEKDISIFAGTFNISGKIPKDDIKDWIFPKSMSKEDEMADLYVIGLEEVVELTPGHMLATDPYVRQFWEKKILTLLNGPGRKKKYIRLWSTQLGGILLLLFMNETEYSKVKHIEGDVKKTGFGGMASNKGAVAVSFKYSATRFCVLVSHLAAGLENVEQRHNDYKTIAKSIRFSKGLRIKDHDAIIWMGDFNYRILMSNEDVRRKIVSKEYASLFEKDQLNQQMIAGESFPYFHEMAIDFPPTYKFDPGTKNYDTSEKMRIPAWTDRILSRGEVLEQLEYKCCEDILFSDHRPVYAIFRARVTVVDEQKKTTLGTQIYEKIMERLEGLDDDEKIAVLSDDAFVIESFEGSDSIAGPTHSPTPIPEPKRGRKLPPPSSDLKKWWIGSGKQVKVVLDVDPAVYMINPKRDPNPFVENEDEPLFIER"}]}