{"ymdb_id":"YMDB00285","created_at":"2011-05-29T18:02:07.000Z","updated_at":"2016-09-08T18:35:17.000Z","name":"Phytosphingosine","cas":"554-62-1","state":"Solid","melting_point":"102-103 oC","description":"Phytosphingosine (4-hydroxysphinganine) is an intermediate in sphingolipid metabolism pathway. Sphingolipids are essential components of the plasma membrane in all eukaryotic cells. S. cerevisiae cells make three complex sphingolipids: inositol-phosphoceramide (IPC), mannose-inositol-phosphoceramide (MIPC), and mannosyl-diinositol-phosphorylceramide (M(IP)2C). Sphingolipid long chain bases (LCBs) - dihydrosphingosine (DHS) and phytosphingosine (PHS) - are implicated as secondary messengers in vital signaling pathways. [Biocyc SPHINGOLIPID-SYN-PWY]","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"endoplasmic reticulum","synthesis_reference":"Mulzer, Johann; Brand, Clemens. Enantioselective syntheses of D- and L-ribo- and arabino-C18-phytosphingosine from (R)-2,3-O-isopropylideneglyceraldehyde. Tetrahedron (1986), 42(21), 5961-8.","chebi_id":"46961","hmdb_id":"HMDB04610","kegg_id":"C12144","pubchem_id":"122121","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":"PHYTOSPINGOSINE","iupac":"(2S,3S,4R)-2-aminooctadecane-1,3,4-triol","traditional_iupac":"phytosphingosine","logp":"3.6976906383333326","pka":"14.815152200058375","alogps_solubility":"4.46e-02 g/l","alogps_logp":"3.96","alogps_logs":"-3.85","acceptor_count":"4","donor_count":"4","rotatable_bond_count":"16","polar_surface_area":"86.71","refractivity":"92.2909","polarizability":"41.04821545288787","formal_charge":"0","physiological_charge":"1","pka_strongest_basic":"8.908333300303687","pka_strongest_acidic":"13.447718983386185","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["(+)-D-ribo-Phytosphingosine","[2S-(2R*,3R*,4S*)]-2-amino-1,3,4-Octadecanetriol","4-D-hydroxy-Sphinganine","4-D-Hydroxysphinganine","4D-Hydroxysphinganine","C18-Phytosphingosine","D-ribo-1,3,4-Trihydroxy-2-aminooctadecane","D-ribo-2-amino-1,3,4-Octadecanetriol"],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"},{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"},{"name":"Biosynthesis of unsaturated fatty acids (docosanoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (icosanoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (stearoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (tetracosanoyl-CoA)","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":16730802,"citation":"Dickson, R. C., Sumanasekera, C., Lester, R. L. (2006). \"Functions and metabolism of sphingolipids in Saccharomyces cerevisiae.\" Prog Lipid Res 45:447-465."},{"pubmed_id":10900202,"citation":"Mao, C., Xu, R., Bielawska, A., Szulc, Z. M., Obeid, L. M. (2000). \"Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide.\" J Biol Chem 275:31369-31378."},{"pubmed_id":9872981,"citation":"Jiang, J. C., Kirchman, P. A., Zagulski, M., Hunt, J., Jazwinski, S. M. (1998). \"Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.\" Genome Res 8:1259-1272."},{"pubmed_id":12531550,"citation":"Obeid, L. M., Okamoto, Y., Mao, C. (2002). \"Yeast sphingolipids: metabolism and biology.\" Biochim Biophys Acta 1585:163-171."}],"proteins":[{"created_at":"2011-05-24T21:19:36.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Alkaline ceramidase YDC1","uniprot_id":"Q02896","uniprot_name":"YDC1_YEAST","enzyme":true,"transporter":false,"gene_name":"YDC1","num_residues":317,"molecular_weight":"37230.5","theoretical_pi":"7.17","general_function":"Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides","specific_function":"Catalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"43-60;67-89;99-121;134-156;160-182;203-225;240-262","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein","genbank_gene_id":"AF214455","genbank_protein_id":"10764171","gene_card_id":"YDC1","chromosome_location":"chromosome 16","locus":"YPL087W","synonyms":[],"enzyme_classes":["3.5.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" membrane lipid metabolic process"},{"category":"Process","description":" sphingolipid metabolic process"},{"category":"Process","description":" sphingoid metabolic process"},{"category":"Process","description":" ceramide metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"}],"pfams":[{"name":"aPHC","identifier":"PF05875"}],"pathways":[],"gene_sequence":"ATGCTGTTCAGCTGGCCTTATCCAGAAGCCCCGATTGAAGGTTATTGGGGCAAGCCAACTTCTCTGATTGATTGGTGCGAGGAGAATTATGTCGTATCCCCCTATATTGCAGAATGGTCAAATACTATTACCAATAGTATATTCTTAATGACCGCCTTCTATTCTACATATAGCGCTTGGCGTAATAAGTTAGAAACAAGGTATATATTGATAGGAATGGGGTTCTCGCTGGTTGGTATTGGTTCGTGGTTATTTCATATGACTTTACAGTATCGTTATCAATTGCTAGACGAACTACCAATGCTGTATGCGACCATCATCCCATCGTGGAGTATTTTTGCAGAAACTCAAGAAATCTTGATTAAGGATGAGAAGAAAAGGAAGGAAAGCTCATTTAGAATCCAAATGGTCATTTCTTTTATCATGTGTGGTATAGTCACCATTTTAACCTGGATTTACGTTGTCGTCCAAAAGCCAGCAATTTTCCAAGTCCTTTATGGTATATTGACGCTTCTAGTTGTGGTTCTTTCTGGCTGGCTGACCTACTATCACGTTCATGATTCATTTGCAAAGAAAAATCTTTTTATTACTATGGTTATGGGCATGATTCCTTTTGTCATTGGGTTCATTTGCTGGCAACTAGATATTCACCTGTGTTCTTTTTGGATCTATATCCGGAGAACATATTTGGCCCTGCCATTAGGTGTTCTATTGGAACTGCATGCTTGGTGGCATCTTTTGACCGGTACTGGTGTCTATATCTTCGTCGTGTATTTGCAATATTTGAGAATATTAACCCATGGAAATCCAAATGACTTCTTATTTATATGGAGGTGGGGATTTTTCCCTGAGCTGGTAAGAAAGGGCTTACCGATTGGTACTTCTTATTCACTGGAGTATCTGGGGCCAATTGTAAATACACAGGTAGATGATGAAACAAAAAAGAATAACTAA","protein_sequence":"MLFSWPYPEAPIEGYWGKPTSLIDWCEENYVVSPYIAEWSNTITNSIFLMTAFYSTYSAWRNKLETRYILIGMGFSLVGIGSWLFHMTLQYRYQLLDELPMLYATIIPSWSIFAETQEILIKDEKKRKESSFRIQMVISFIMCGIVTILTWIYVVVQKPAIFQVLYGILTLLVVVLSGWLTYYHVHDSFAKKNLFITMVMGMIPFVIGFICWQLDIHLCSFWIYIRRTYLALPLGVLLELHAWWHLLTGTGVYIFVVYLQYLRILTHGNPNDFLFIWRWGFFPELVRKGLPIGTSYSLEYLGPIVNTQVDDETKKNN"},{"created_at":"2011-05-24T21:46:35.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAG1","uniprot_id":"P38703","uniprot_name":"LAG1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAG1","num_residues":411,"molecular_weight":"48454.10156","theoretical_pi":"9.17","general_function":"Involved in protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;177-197;212-232;252-272;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"AY558514","genbank_protein_id":"45270918","gene_card_id":"LAG1","chromosome_location":"chromosome 8","locus":"YHL003C","synonyms":["Longevity assurance factor 1","Longevity assurance gene 1 protein","Longevity assurance protein 1"],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGACATCAGCTACGGACAAATCTATCGATAGGTTAGTTGTTAATGCAAAAACAAGAAGACGAAACTCTTCCGTGGGTAAAATTGATTTAGGTGATACAGTTCCTGGCTTTGCAGCCATGCCTGAAAGTGCTGCCTCTAAAAATGAGGCCAAAAAAAGGATGAAAGCCTTGACTGGTGACTCTAAAAAGGATAGTGACCTACTGTGGAAGGTTTGGTTTTCATATAGAGAAATGAATTACCGTCATAGTTGGTTGACACCATTCTTCATACTTGTATGCGTGTATAGCGCGTACTTTTTATCTGGGAATAGAACAGAATCAAACCCGCTGCACATGTTCGTAGCCATATCATATCAAGTTGATGGCACAGACTCATATGCAAAAGGTATCAAAGATTTGAGTTTTGTGTTTTTCTACATGATTTTCTTCACATTTTTACGTGAGTTTTTGATGGATGTTGTAATTCGACCATTCACGGTATACCTAAATGTTACTTCCGAGCATCGTCAAAAGCGTATGCTAGAACAAATGTATGCCATATTTTATTGCGGAGTTTCAGGGCCCTTTGGTCTTTATATTATGTACCATAGTGATTTGTGGTTGTTCAAGACAAAACCAATGTACAGAACATATCCTGTTATAACCAATCCGTTCTTGTTTAAGATATTTTACTTGGGTCAAGCGGCATTTTGGGCGCAACAGGCTTGTGTTCTTGTTCTACAATTAGAAAAGCCAAGAAAGGATTACAAGGAATTGGTTTTTCATCACATTGTGACATTATTATTAATTTGGTCATCATATGTTTTCCATTTTACCAAAATGGGATTGGCTATCTATATTACTATGGATGTGTCAGATTTTTTCCTTTCTTTGTCTAAGACATTAAACTATCTGAATTCTGTATTTACTCCCTTTGTGTTCGGCTTGTTCGTGTTCTTTTGGATCTATCTGCGCCATGTCGTGAATATCAGAATATTATGGTCAGTCTTAACAGAATTCCGTCATGAAGGTAATTATGTGTTGAATTTTGCCACACAACAATACAAATGTTGGATTTCGTTGCCAATTGTATTTGTACTAATTGCTGCGTTACAATTAGTTAACCTGTATTGGCTGTTTTTAATTCTTAGAATCTTGTACAGATTGATATGGCAAGGTATCCAAAAGGACGAAAGAAGTGACAGTGATTCTGATGAGAGCGCTGAAAATGAAGAATCTAAGGAAAAGTGTGAATAA","protein_sequence":"MTSATDKSIDRLVVNAKTRRRNSSVGKIDLGDTVPGFAAMPESAASKNEAKKRMKALTGDSKKDSDLLWKVWFSYREMNYRHSWLTPFFILVCVYSAYFLSGNRTESNPLHMFVAISYQVDGTDSYAKGIKDLSFVFFYMIFFTFLREFLMDVVIRPFTVYLNVTSEHRQKRMLEQMYAIFYCGVSGPFGLYIMYHSDLWLFKTKPMYRTYPVITNPFLFKIFYLGQAAFWAQQACVLVLQLEKPRKDYKELVFHHIVTLLLIWSSYVFHFTKMGLAIYITMDVSDFFLSLSKTLNYLNSVFTPFVFGLFVFFWIYLRHVVNIRILWSVLTEFRHEGNYVLNFATQQYKCWISLPIVFVLIAALQLVNLYWLFLILRILYRLIWQGIQKDERSDSDSDESAENEESKEKCE"},{"created_at":"2011-05-26T16:06:16.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Alkaline ceramidase YPC1","uniprot_id":"P38298","uniprot_name":"YPC1_YEAST","enzyme":true,"transporter":false,"gene_name":"YPC1","num_residues":316,"molecular_weight":"36419.39844","theoretical_pi":"8.41","general_function":"Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides","specific_function":"Hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine. Prefers phytoceramide. Has also reverse hydrolysis activity, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide","reactions":[{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"69-89;94-114;136-156;161-181;196-216;229-249","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein","genbank_gene_id":"AF191745","genbank_protein_id":"7248652","gene_card_id":"YPC1","chromosome_location":"chromosome 2","locus":"YBR183W","synonyms":[],"enzyme_classes":["3.5.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" membrane lipid metabolic process"},{"category":"Process","description":" sphingolipid metabolic process"},{"category":"Process","description":" sphingoid metabolic process"},{"category":"Process","description":" ceramide metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"}],"pfams":[{"name":"aPHC","identifier":"PF05875"}],"pathways":[],"gene_sequence":"ATGGGAATATTTCGTTGGAACTATCCAGAGAGTTCTGTCCCCGGCGTTTGGGGAGAAACAACTTCCACTATTGACTGGTGTGAGGAGAACTATGTCGTTTCTCCCTATATTGCCGAGTGGTCAAACACTTTAACTAACAGCGTATTCATACTGTCAGCGATTTACACAACTTACTCTGCTTACAAGAATAAATTAGAAAAAAGGTTTTTACTTATTGGCTTCGGGTACGGTTTGGTCGGAGTAGGATCATGGCTATTTCATATGACACTGAAGTATAGATTCCAACTATTGGATGAACTTCCAATGATATACGCCATGTGCATTCCGACATGGAGTTTAGTATGCGAGGCCAAAGAGGCATTACTTAACGGAGATAATCACAAGAAGGTTCCTCTATTTGAACAGATATTCATCGGCGTAATTATCGGCCTGGCCGTTACAACAGCAAGCATACTCTACGTTATTTACAAAAATGTCGATATCCATCAAATTTTGTTTGGCGTACAGATTGTAGTTGTGGCTGCTACTGCAGGAAGTTTGACGTACAGATACGTCCATGATCCACTTGCCAAAAGAAATCTCAAGGCTTCAATGGCGCTCGGCGCAATTTTGTTCTTATCTGGCTACATTTCGTGGCTACTTGATATACACTATTGTTCGTTCTGGGTGCACGTTAGAAGAAGTATTTTGGCTTTACCACTTGGTGTACTGCTTGAACCACACGGATGGTGGCATATATTAACTGGTATGGGGATTTATTTCTACATTGTTTCTTTGGAACATTTAAGGGTCATTACGCTCAACGTCAGCTGCAATTACCAGTTCATCTGGAGATGGAAAGTCTTCCCTGAACTGATATGGAAAGGGCGCAAACCCTCAACAAGATATTCACTTGAACTATTTGGCCCATACGTAGAAGATCAATCAATTGAAGTTAAAAAGGAGAAGTAA","protein_sequence":"MGIFRWNYPESSVPGVWGETTSTIDWCEENYVVSPYIAEWSNTLTNSVFILSAIYTTYSAYKNKLEKRFLLIGFGYGLVGVGSWLFHMTLKYRFQLLDELPMIYAMCIPTWSLVCEAKEALLNGDNHKKVPLFEQIFIGVIIGLAVTTASILYVIYKNVDIHQILFGVQIVVVAATAGSLTYRYVHDPLAKRNLKASMALGAILFLSGYISWLLDIHYCSFWVHVRRSILALPLGVLLEPHGWWHILTGMGIYFYIVSLEHLRVITLNVSCNYQFIWRWKVFPELIWKGRKPSTRYSLELFGPYVEDQSIEVKKEK"},{"created_at":"2011-05-26T16:11:34.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAC1","uniprot_id":"P28496","uniprot_name":"LAC1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAC1","num_residues":418,"molecular_weight":"48991.60156","theoretical_pi":"9.81","general_function":"Involved in identical protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;173-193;222-242;260-280;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z28008","genbank_protein_id":"485983","gene_card_id":"LAC1","chromosome_location":"chromosome 11","locus":"YKL008C","synonyms":[],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGTCGACAATAAAGCCAAGCCCTTCAAACAACAATTTGAAAGTGAGGTCAAGACCAAGACGCAAGTCTTCCATAGGTAAGATCGACCTCGGGGACACTGTACCTAGTTTAGGTACTATGTTCGAGACAAAAGAATCTAAAACGGCTGCTAAAAGGCGTATGCAGAGATTATCTGAAGCCACCAAAAATGATAGCGACCTGGTCAAGAAAATCTGGTTTTCATTCCGAGAGATAAGTTACCGTCATGCCTGGATAGCTCCCTTGATGATTTTAATCGCGGTATATAGTGCCTATTTCACTTCTGGTAACACTACAAAGACAAATGTGTTACATAGATTTGTCGCTGTGTCATACCAAATAGGTGATACCAACGCATATGGTAAAGGTATTAACGATTTGTGCTTTGTATTTTACTATATGATTTTTTTCACATTCTTACGTGAATTCCTAATGGATGTTGTCATTAGACCGTTCGCTATTAGGTTACACGTCACTTCTAAGCACAGAATAAAAAGAATCATGGAACAAATGTACGCTATTTTCTACACCGGTGTTTCCGGTCCTTTCGGGATATATTGTATGTACCATTCGGATTTATGGTTTTTCAACACAAAGGCAATGTACAGAACATATCCAGATTTCACTAATCCCTTCTTATTCAAGGTATTCTATTTGGGTCAAGCTGCATTTTGGGCTCAACAAGCCTGCATTCTTGTATTGCAACTAGAAAAGCCAAGAAAAGATCATAACGAGTTGACTTTCCATCATATTGTTACTTTACTATTGATTTGGTCTTCCTACGTATTTCATTTCACTAAAATGGGACTGCCAATCTATATCACAATGGATGTTTCTGATTTTCTTTTGTCATTCTCCAAAACTCTAAATTATTTGGACTCTGGATTGGCTTTTTTTTCTTTTGCTATCTTTGTTGTTGCGTGGATTTATTTGCGTCATTACATAAATTTAAAGATCCTATGGTCCGTTTTAACGCAATTTCGCACGGAAGGTAACTATGTCTTGAATTTTGCCACTCAGCAATATAAATGTTGGATTTCCTTACCAATTGTCTTTGTATTGATAGGCGCTTTGCAATTAGTGAATCTTTATTGGCTGTTCCTTATTTTTAGAGTTCTTTACAGGATTCTATGGAGAGGTATTCTCAAGGATGACAGAAGTGATAGTGAATCAGACGAAGAAAGTGATGAAAGTTCCACTACTCCAACTGACAGTACTCCAACGAAAAAGGATATTTGA","protein_sequence":"MSTIKPSPSNNNLKVRSRPRRKSSIGKIDLGDTVPSLGTMFETKESKTAAKRRMQRLSEATKNDSDLVKKIWFSFREISYRHAWIAPLMILIAVYSAYFTSGNTTKTNVLHRFVAVSYQIGDTNAYGKGINDLCFVFYYMIFFTFLREFLMDVVIRPFAIRLHVTSKHRIKRIMEQMYAIFYTGVSGPFGIYCMYHSDLWFFNTKAMYRTYPDFTNPFLFKVFYLGQAAFWAQQACILVLQLEKPRKDHNELTFHHIVTLLLIWSSYVFHFTKMGLPIYITMDVSDFLLSFSKTLNYLDSGLAFFSFAIFVVAWIYLRHYINLKILWSVLTQFRTEGNYVLNFATQQYKCWISLPIVFVLIGALQLVNLYWLFLIFRVLYRILWRGILKDDRSDSESDEESDESSTTPTDSTPTKKDI"},{"created_at":"2011-05-26T19:42:27.000Z","updated_at":"2011-05-27T15:01:07.000Z","name":"Sphingoid long chain base kinase 4","uniprot_id":"Q12246","uniprot_name":"LCB4_YEAST","enzyme":true,"transporter":false,"gene_name":"LCB4","num_residues":624,"molecular_weight":"69638.60156","theoretical_pi":"6.39","general_function":"Involved in diacylglycerol kinase activity","specific_function":"Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Involved in the biosynthesis of sphingolipids and ceramides. Required with LCB3 for an effective incorporation of DHS into ceramides through a phosphorylation-dephosphorylation cycle. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance","reactions":[{"id":1975,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1976,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2584,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + sphinganine = ADP + sphinganine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2585,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + phytosphingosine = ADP + phytosphingosine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein","genbank_gene_id":"Z75078","genbank_protein_id":"1420417","gene_card_id":"LCB4","chromosome_location":"chromosome 15","locus":"YOR171C","synonyms":["LCB kinase 4","Sphinganine kinase 4"],"enzyme_classes":["2.7.1.91"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" diacylglycerol kinase activity"},{"category":"Process","description":" activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway"},{"category":"Process","description":" signaling"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" cell surface receptor linked signaling pathway"},{"category":"Process","description":" G-protein coupled receptor protein signaling pathway"}],"pfams":[{"name":"DAGK_cat","identifier":"PF00781"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGGTGGTGCAGAAAAAACTTAGGGCTATCTTGACCGATGAAGGTGTATTGATCAAATCGCAATCACACCATATGTTCAATAAGCATGGTCAACTCAGAAGCGGAGATTCTTTATCCTTGTTGAGCTGCTTGTCCTGTCTGGATGATGGAACTTTGAGCTCTGATGGAGGTTCTTTTGATGAGGATGATTCCCTGGAACTGTTGCCTCTTAATACTACCATTCCGTTCAACAGAATTTTGAACGCAAAATATGTGAATGTCGGTCAGAAAGGCTTCAATAATGGCAAAATTTCTTCGAATCCTTTTCAAACGGAAAATCTGAGTTCTTCGTCTGAAAATGACGACGTTGAGAATCATAGTTTGAGCAATGATAAGGCTCCTGTAAGCGAATCACAGTCATTTCCCAAAAAAGACAAGTGGGATACAAAAACGAACACTGTGAAGGTGTCTCCCGATGATTCACAGGATAACTCACCATCTTTAGGGATAAAAGATAATCAACAGTTAATTGAGTTAACTTTTGCTGTACCCAAGGGCCATGATGTTATACCACAAAAATTAACCTTGTTAATAGATCACGTTTCTAGGAAATCGAGAGCAAATACCGGAGAGGAGAACATTTCTTCTGGTACTGTGGAAGAAATCCTGGAAAAAAGTTATGAAAATTCCAAGAGAAACAGATCGATATTAGTCATTATTAATCCCCACGGTGGTAAAGGTACTGCTAAAAATTTATTCCTGACAAAAGCAAGGCCAATACTAGTGGAAAGTGGCTGCAAAATAGAAATTGCATACACAAAATATGCCCGTCACGCCATCGATATTGCCAAAGATTTAGATATCAGCAAATACGATACCATTGCATGTGCCTCGGGTGATGGTATTCCATACGAAGTAATTAATGGGCTTTATAGAAGACCCGACAGAGTGGATGCGTTCAATAAACTAGCCGTAACTCAGCTACCTTGCGGTTCAGGAAATGCTATGAGCATTTCATGTCATTGGACAAATAACCCATCGTACGCCGCTCTGTGCCTTGTCAAATCCATTGAAACAAGAATAGACTTAATGTGTTGTTCCCAACCTTCTTATATGAACGAATGGCCAAGATTATCCTTTTTGAGTCAGACGTACGGCGTTATTGCAGAATCTGATATTAACACTGAATTCATCAGATGGATGGGTCCCGTTAGGTTTAATTTGGGTGTAGCATTCAACATTATCCAAGGTAAGAAATATCCCTGCGAAGTTTTCGTCAAATATGCTGCCAAATCTAAAAAGGAATTAAAAGTTCATTTCTTAGAAAATAAAGATAAAAACAAAGGATGTTTAACCTTCGAACCAAATCCTAGCCCAAACTCTTCGCCGGATTTACTATCTAAAAACAATATCAACAACAGTACAAAAGATGAACTTTCACCGAATTTTCTCAACGAGGACAACTTTAAATTAAAGTATCCGATGACGGAACCAGTACCTAGAGACTGGGAGAAAATGGATTCAGAGCTAACTGATAACTTAACAATCTTTTACACAGGGAAAATGCCGTATATTGCTAAGGACACCAAATTTTTTCCCGCTGCTTTACCAGCGGATGGTACCATTGATTTAGTCATAACGGATGCAAGAATCCCAGTGACAAGAATGACACCAATTTTATTATCCTTGGATAAAGGTTCTCATGTATTAGAGCCAGAAGTTATTCACTCAAAAATATTGGCTTATAAGATTATACCAAAAGTGGAGTCAGGTTTATTTTCAGTGGATGGTGAAAAGTTTCCTTTGGAACCCTTGCAAGTGGAAATAATGCCCATGTTATGCAAGACGTTGCTAAGGAATGGTAGATATATCGATACAGAGTTTGAATCCATGTAG","protein_sequence":"MVVQKKLRAILTDEGVLIKSQSHHMFNKHGQLRSGDSLSLLSCLSCLDDGTLSSDGGSFDEDDSLELLPLNTTIPFNRILNAKYVNVGQKGFNNGKISSNPFQTENLSSSSENDDVENHSLSNDKAPVSESQSFPKKDKWDTKTNTVKVSPDDSQDNSPSLGIKDNQQLIELTFAVPKGHDVIPQKLTLLIDHVSRKSRANTGEENISSGTVEEILEKSYENSKRNRSILVIINPHGGKGTAKNLFLTKARPILVESGCKIEIAYTKYARHAIDIAKDLDISKYDTIACASGDGIPYEVINGLYRRPDRVDAFNKLAVTQLPCGSGNAMSISCHWTNNPSYAALCLVKSIETRIDLMCCSQPSYMNEWPRLSFLSQTYGVIAESDINTEFIRWMGPVRFNLGVAFNIIQGKKYPCEVFVKYAAKSKKELKVHFLENKDKNKGCLTFEPNPSPNSSPDLLSKNNINNSTKDELSPNFLNEDNFKLKYPMTEPVPRDWEKMDSELTDNLTIFYTGKMPYIAKDTKFFPAALPADGTIDLVITDARIPVTRMTPILLSLDKGSHVLEPEVIHSKILAYKIIPKVESGLFSVDGEKFPLEPLQVEIMPMLCKTLLRNGRYIDTEFESM"},{"created_at":"2011-05-26T19:54:39.000Z","updated_at":"2011-05-27T15:01:07.000Z","name":"Sphingoid long chain base kinase 5","uniprot_id":"Q06147","uniprot_name":"LCB5_YEAST","enzyme":true,"transporter":false,"gene_name":"LCB5","num_residues":687,"molecular_weight":"77564.60156","theoretical_pi":"6.86","general_function":"Involved in diacylglycerol kinase activity","specific_function":"Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Redundant to LCB4, is only responsible for few percent of the total activity. Involved in the biosynthesis of sphingolipids and ceramides. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance","reactions":[{"id":1975,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1976,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2584,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + sphinganine = ADP + sphinganine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2585,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + phytosphingosine = ADP + phytosphingosine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Peripheral membrane protein","genbank_gene_id":"U17244","genbank_protein_id":"577178","gene_card_id":"LCB5","chromosome_location":"chromosome 12","locus":"YLR260W","synonyms":["LCB kinase 5","Sphinganine kinase 5"],"enzyme_classes":["2.7.1.91"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" diacylglycerol kinase activity"},{"category":"Process","description":" activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway"},{"category":"Process","description":" signaling"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" cell surface receptor linked signaling pathway"},{"category":"Process","description":" G-protein coupled receptor protein signaling pathway"}],"pfams":[{"name":"DAGK_cat","identifier":"PF00781"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGACTTTGAAACCTTCAAAGAGACGTAAGGGCAGGTCTCGCCATTCCAGGAAGAAGCAAATAACGTCAGCGATACTGACTGAGGAAGGAATAATGATCAAGGCAAAACCATCAAGTCCTTACACATACGCAAATAGAATGGCAGATAAACGAAGTCGCAGCAGCATTGACAACATCAGTAGAACTAGCTTTCAAAGCAACATCAGTAGAACTAGCTTTCAAAGCAACAGTGATAACAACAGTATATTTGAAACGGCTTCACTAATTAGCTGTGTTACCTGTTTAAGCGATACTGATACAATAGACAGATCGGAAACATCGACAACGGATACAAGTAAAGATGATCTTTCTGCTAATCCAAAACTTCATTATCCTTCGGTGAATGGTCAATTGCCAGCAAACACCGTTATCCCCTATGGACGAATTCTGGATGCCAGATACATTGAAAAGGAACCTCTGCATTATTATGATGCCAATTCATCACCCAGTTCACCTTTAAGCAGCTCAATGAGTAACATTAGTGAAAAGTGTGATCTTGATGAATTAGAGTCTTCCCAAAAAAAAGAAAGGAAGGGCAACTCGCTATCGCGAGGAAGTAACAGTAGTAGTAGCCTCCTGACTTCCAGATCTCCTTTTACGAAACTAGTAGAGGTTATATTTGCTAGGCCAAGACGGCATGACGTTGTACCCAAAAGGGTTTCATTGTATATTGACTATAAACCCCATTCATCTTCTCACTTAAAAGAAGAAGATGACTTGGTTGAGGAGATTTTAAAGAGAAGCTACAAAAACACTAGAAGGAACAAATCCATATTTGTGATCATTAATCCGTTTGGTGGTAAAGGTAAGGCGAAAAAACTGTTTATGACAAAGGCAAAGCCGTTACTATTAGCAAGTCGGTGTTCCATAGAAGTGGTTTATACAAAATACCCTGGTCATGCTATAGAGATCGCGCGGGAAATGGATATTGACAAATATGACACTATTGCTTGCGCTTCGGGAGATGGCATTCCTCATGAGGTGATCAATGGGTTATACCAAAGGCCTGATCATGTCAAAGCATTCAACAATATCGCCATTACAGAAATTCCATGCGGATCAGGTAACGCAATGAGCGTATCCTGCCACTGGACAAACAATCCTTCGTACTCAACTTTATGCTTAATTAAATCGATAGAGACTAGAATTGATTTGATGTGTTGTTCGCAGCCTTCTTATGCAAGAGAGCACCCAAAGTTATCATTTTTAAGTCAAACATATGGTCTCATTGCAGAAACTGACATAAACACTGAATTTATTAGATGGATGGGACCTGCAAGGTTTGAATTGGGTGTAGCCTTCAATATCATACAAAAAAAAAAATATCCTTGTGAGATATATGTAAAGTATGCTGCCAAATCAAAAAACGAGTTAAAAAATCATTACCTGGAACACAAAAATAAAGGGTCGTTAGAATTCCAGCATATTACTATGAACAAAGATAACGAGGATTGTGATAATTACAATTACGAAAATGAATACGAAACCGAAAACGAAGATGAAGATGAAGATGCGGATGCGGATGACGAAGACTCCCACTTGATATCTCGTGATCTGGCAGATTCTAGTGCTGATCAAATTAAAGAGGAAGATTTCAAAATAAAATATCCATTAGATGAAGGTATCCCTAGTGACTGGGAAAGATTGGATCCTAATATTTCGAACAACCTAGGTATCTTCTATACGGGTAAAATGCCATATGTGGCTGCTGACACTAAATTCTTTCCGGCAGCGCTTCCTTCAGATGGTACAATGGATATGGTTATCACCGATGCAAGAACCTCGTTGACGAGGATGGCACCAATCCTGCTGGGACTAGATAAGGGTTCCCATGTTTTACAACCGGAAGTCTTACACTCTAAAATTTTGGCATACAAGATAATACCAAAGCTAGGGAACGGCTTGTTCTCTGTCGATGGCGAGAAATTTCCTCTAGAGCCCCTTCAAGTCGAAATTATGCCACGCTTATGCAAGACGTTACTGAGAAATGGCCGTTATGTGGACACAGATTTCGATTCTATGTGA","protein_sequence":"MTLKPSKRRKGRSRHSRKKQITSAILTEEGIMIKAKPSSPYTYANRMADKRSRSSIDNISRTSFQSNISRTSFQSNSDNNSIFETASLISCVTCLSDTDTIDRSETSTTDTSKDDLSANPKLHYPSVNGQLPANTVIPYGRILDARYIEKEPLHYYDANSSPSSPLSSSMSNISEKCDLDELESSQKKERKGNSLSRGSNSSSSLLTSRSPFTKLVEVIFARPRRHDVVPKRVSLYIDYKPHSSSHLKEEDDLVEEILKRSYKNTRRNKSIFVIINPFGGKGKAKKLFMTKAKPLLLASRCSIEVVYTKYPGHAIEIAREMDIDKYDTIACASGDGIPHEVINGLYQRPDHVKAFNNIAITEIPCGSGNAMSVSCHWTNNPSYSTLCLIKSIETRIDLMCCSQPSYAREHPKLSFLSQTYGLIAETDINTEFIRWMGPARFELGVAFNIIQKKKYPCEIYVKYAAKSKNELKNHYLEHKNKGSLEFQHITMNKDNEDCDNYNYENEYETENEDEDEDADADDEDSHLISRDLADSSADQIKEEDFKIKYPLDEGIPSDWERLDPNISNNLGIFYTGKMPYVAADTKFFPAALPSDGTMDMVITDARTSLTRMAPILLGLDKGSHVLQPEVLHSKILAYKIIPKLGNGLFSVDGEKFPLEPLQVEIMPRLCKTLLRNGRYVDTDFDSM"},{"created_at":"2011-05-27T06:05:18.000Z","updated_at":"2011-05-27T15:01:25.000Z","name":"Dihydrosphingosine 1-phosphate phosphatase LCB3","uniprot_id":"P47013","uniprot_name":"DS1P1_YEAST","enzyme":true,"transporter":false,"gene_name":"LCB3","num_residues":409,"molecular_weight":"47371.30078","theoretical_pi":"9.13","general_function":"Involved in catalytic activity","specific_function":"Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling","reactions":[{"id":1973,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1974,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"87-107;113-133;183-203;208-228;246-266;277-297;316-336;385-405","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"X87371","genbank_protein_id":"854562","gene_card_id":"LCB3","chromosome_location":"chromosome 10","locus":"YJL134W","synonyms":["Long-chain base protein 3","Sphingolipid resistance protein 2"],"enzyme_classes":["3.1.3.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PAP2","identifier":"PF01569"}],"pathways":[],"gene_sequence":"ATGGTAGATGGACTGAATACCTCGAACATTAGGAAAAGAGCCAGGACTCTCTCTAACCCCAATGACTTTCAAGAGCCTAATTACTTGCTGGATCCCGGTAATCATCCCTCAGATCATTTTCGAACTCGAATGTCCAAATTTCGGTTTAATATTAGAGAGAAGCTGTTAGTGTTTACCAACAATCAATCATTCACATTAAGCCGCTGGCAAAAGAAGTACCGTTCTGCGTTTAATGATCTCTACTTTACTTATACTTCCTTAATGGGATCGCATACCTTCTATGTTCTGTGTTTACCTATGCCCGTGTGGTTTGGATATTTTGAAACAACAAAAGATATGGTTTATATCTTGGGATATTCTATCTACTTGAGTGGTTTTTTTAAAGATTACTGGTGCTTGCCCAGGCCTAGAGCACCTCCATTACATCGAATTACGTTAAGTGAATATACAACGAAGGAATATGGTGCTCCAAGCTCCCATACAGCAAATGCAACAGGAGTGAGTCTCTTGTTTCTCTACAACATCTGGAGGATGCAAGAATCTTCTGTCATGGTCCAACTATTGTTGTCATGTGTGGTTTTATTTTATTATATGACTTTGGTTTTCGGTAGAATATACTGTGGGATGCATGGCATATTAGATTTAGTAAGCGGTGGGCTCATTGGAATAGTGTGTTTCATTGTTAGGATGTATTTCAAGTACAGGTTTCCGGGTTTACGCATTGAGGAGCATTGGTGGTTTCCTTTGTTTAGTGTGGGATGGGGTCTTCTTCTTTTGTTTAAACATGTTAAGCCCGTAGACGAATGTCCTTGCTTCCAAGATAGTGTTGCGTTCATGGGCGTTGTGTCAGGTATTGAATGCTGTGATTGGTTGGGCAAAGTGTTTGGAGTCACCCTGGTGTACAATTTGGAACCTAACTGTGGCTGGCGGTTAACCTTAGCCAGGCTGCTGGTGGGCCTACCGTGCGTTGTTATCTGGAAGTACGTGATCAGCAAACCGATGATCTACACGTTATTGATCAAAGTTTTCCATCTGAAGGATGACAGAAACGTTGCGGCAAGAAAAAGACTGGAGGCCACGCACAAAGAAGGTGCAAGCAAGTACGAATGTCCATTATATATTGGAGAGCCCAAGATTGACATTCTAGGTAGATTTATTATCTATGCTGGCGTTCCATTCACCGTTGTAATGTGCAGCCCCGTCCTATTTTCCCTCTTAAATATAGCATAA","protein_sequence":"MVDGLNTSNIRKRARTLSNPNDFQEPNYLLDPGNHPSDHFRTRMSKFRFNIREKLLVFTNNQSFTLSRWQKKYRSAFNDLYFTYTSLMGSHTFYVLCLPMPVWFGYFETTKDMVYILGYSIYLSGFFKDYWCLPRPRAPPLHRITLSEYTTKEYGAPSSHTANATGVSLLFLYNIWRMQESSVMVQLLLSCVVLFYYMTLVFGRIYCGMHGILDLVSGGLIGIVCFIVRMYFKYRFPGLRIEEHWWFPLFSVGWGLLLLFKHVKPVDECPCFQDSVAFMGVVSGIECCDWLGKVFGVTLVYNLEPNCGWRLTLARLLVGLPCVVIWKYVISKPMIYTLLIKVFHLKDDRNVAARKRLEATHKEGASKYECPLYIGEPKIDILGRFIIYAGVPFTVVMCSPVLFSLLNIA"},{"created_at":"2011-05-27T06:05:51.000Z","updated_at":"2011-05-27T15:01:25.000Z","name":"Dihydrosphingosine 1-phosphate phosphatase YSR3","uniprot_id":"P23501","uniprot_name":"DS1P2_YEAST","enzyme":true,"transporter":false,"gene_name":"YSR3","num_residues":404,"molecular_weight":"46487.69922","theoretical_pi":"7.73","general_function":"Involved in catalytic activity","specific_function":"Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling","reactions":[{"id":1973,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1974,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"87-107;114-134;155-176;183-203;216-236;242-262;320-340;380-400","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z28278","genbank_protein_id":"486509","gene_card_id":"YSR3","chromosome_location":"chromosome 11","locus":"YKR053C","synonyms":["Long-chain base protein 2","Sphingolipid resistance protein 3"],"enzyme_classes":["3.1.3.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PAP2","identifier":"PF01569"}],"pathways":[],"gene_sequence":"ATGACCATTATTCAGACGGTTACTGAATTGGGTGTTACCGAGGACACCATTAAGGTTCAGATGGCTCCTTCCGGCGGCAAACACCTATTGGCAGATCCCGGTAATCATCCAGCGGAGCATTTTGAGAGCCAGATGTCGTGGCTAAGGTTTCAAACAAGGCAGTATCTAACTAGATTCACAGACAACCAATCAGATTTCGTACATTCTTTACAAAAAAAGCACAGAACGCCTTTTAGAGACGTTTATTTCAAATACACTTCGCTTATGGGTTCCCACATGTTTTATGTTATCGTGCTTCCCATGCCTGTGTGGCTTGGATACCGCGATTTAACACGGGACATGATCTACGTTCTTGGTTATTCAATTTATTTGAGTGGCTACTTAAAGGATTATTGGTGCCTACCAAGGCCAAAATCACCGCCAGTTGACAGAATCACACTAAGTGAATACACTACGAAAGAATATGGTGCACCCAGTTCACATTCTGCTAACGCTACTGCGGTAAGTCTATTATTCTTTTGGAGAATATGTTTATCTGACACACTGGTATGGCCAACAAAGCTTCTTTTACTGAGTCTGGTGATATTTTACTACTTAACCCTGGTTTTTGGTAGAGTTTACTGCGGTATGCATGGTATGCTGGATTTATTTAGCGGCGCCGCAGTTGGAGCTATCTGTTTTTTTATAAGAATCTGGGTGGTGCATGCTTTACGAAATTTCCAGATTGGTGAACATCTCTGGTTTCCCCTTTTGAGTGTAGCATGGGGCTTGTTTATTCTGTTTAACCACGTCAGGCCCATTGATGAATGTCCTTGTTTCGAAGATAGCGTAGCGTTCATTGGCGTAGTCAGTGGGCTGGATTGCAGCGACTGGTTAACCGAAAGATACGGATGGAACCTTGTATGTAGTAGGTACGCATCATGTGGTTCTAAGGTGTTCTTGAGGCCTCTGGTAGGTGTCGCTTCTGTGATTGTTTGGAAAGACGTCATTAGCAAGACAGCTGTCTACACGCTGTTAATTAAACTACTCAGATTTCACGATGATAGAAGCGAAAAGGTTCATTTCCATAACGAGACAAGTGAAGAAGAAGAGTGTTTATTGTACAGCGGTGTTTCCAAAGTGGAAATCGTCGGAAGGTTTCTCATATACGCAGGTATACCTACAACCGTCTTTTTGCTATGCCCAGTTTTTTTCACTTGGACAAACTTAAGGTAG","protein_sequence":"MTIIQTVTELGVTEDTIKVQMAPSGGKHLLADPGNHPAEHFESQMSWLRFQTRQYLTRFTDNQSDFVHSLQKKHRTPFRDVYFKYTSLMGSHMFYVIVLPMPVWLGYRDLTRDMIYVLGYSIYLSGYLKDYWCLPRPKSPPVDRITLSEYTTKEYGAPSSHSANATAVSLLFFWRICLSDTLVWPTKLLLLSLVIFYYLTLVFGRVYCGMHGMLDLFSGAAVGAICFFIRIWVVHALRNFQIGEHLWFPLLSVAWGLFILFNHVRPIDECPCFEDSVAFIGVVSGLDCSDWLTERYGWNLVCSRYASCGSKVFLRPLVGVASVIVWKDVISKTAVYTLLIKLLRFHDDRSEKVHFHNETSEEEECLLYSGVSKVEIVGRFLIYAGIPTTVFLLCPVFFTWTNLR"},{"created_at":"2011-05-27T06:06:25.000Z","updated_at":"2011-07-22T17:54:24.000Z","name":"Sphingolipid C4-hydroxylase SUR2","uniprot_id":"P38992","uniprot_name":"SUR2_YEAST","enzyme":true,"transporter":false,"gene_name":"SUR2","num_residues":349,"molecular_weight":"40734.0","theoretical_pi":"8.73","general_function":"Involved in iron ion binding","specific_function":"Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin","reactions":[{"id":1370,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1372,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1896,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":3889,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006408","source":"Smpdb"},{"id":14345,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006856","source":"Smpdb"},{"id":14389,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006900","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"9-29;50-70;99-119;148-168;209-229","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"U07171","genbank_protein_id":"458718","gene_card_id":"SUR2","chromosome_location":"chromosome 4","locus":"YDR297W","synonyms":["Syringomycin response protein 2"],"enzyme_classes":["1.-.-.-"],"go_classes":[{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" endoplasmic reticulum"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"}],"pfams":[{"name":"FA_hydroxylase","identifier":"PF04116"}],"pathways":[{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"},{"name":"Sphingolipid 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