{"ymdb_id":"YMDB00282","created_at":"2011-05-29T18:01:52.000Z","updated_at":"2016-09-08T18:35:17.000Z","name":"Biotin","cas":"58-85-5","state":"Solid","melting_point":"232 oC","description":"Biotin is a water soluble, heterocyclic cofactor for a small number of enzymes that facilitate the transfer of CO2 during carboxylation, decarboxylation, and transcarboxylation reactions involved in fatty acid and carbohydrate metabolism. Biotin biosynthesis is found in plants, bacteria, and certain fungi. [Biocyc PWY0-1507]","experimental_water_solubility":"0.22 mg/mL at 25 oC [MERCK INDEX (1996)]","experimental_logp_hydrophobicity":".","location":"extracellular;cytoplasm","synthesis_reference":"Corey, E. J.; Mehrotra, Mukund M.  A simple and enantioselective synthesis of (+)-biotin.  Tetrahedron Letters  (1988),  29(1),  57-60.","chebi_id":"15956","hmdb_id":"HMDB00030","kegg_id":"C00120","pubchem_id":"171548","cs_id":"149962","foodb_id":null,"wikipedia_link":"Biotin","biocyc_id":"BIOTIN","iupac":"5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid","traditional_iupac":"5-[(3aS,4S,6aR)-2-oxo-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid","logp":"0.31942364800000006","pka":"13.546990539562877","alogps_solubility":"1.22e+00 g/l","alogps_logp":"0.17","alogps_logs":"-2.30","acceptor_count":"3","donor_count":"3","rotatable_bond_count":"5","polar_surface_area":"78.42999999999999","refractivity":"60.0509","polarizability":"24.919241786433474","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-1.863639696129737","pka_strongest_acidic":"4.4043165776835425","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["-(+)-biotin","(+)-Biotin","(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valerate","(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid","(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valerate","(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid","1swk","1swn","1swr","5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate","5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid","Biodermatin","Bioepiderm","Bios h","Bios II","Biotin","cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valerate","cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid","cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid","cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid","Coenzyme R","D-(+)-biotin","d-Biotin","D-biotin factor s","D(+)-Biotin","delta-(+)-Biotin","delta-Biotin","delta-biotin factor s","Factor s","hexahydro-2-oxo-[3aS-(3aa,4b,6aa)]-1H-Thieno[3,4-d]imidazole-4-pentanoate","hexahydro-2-oxo-[3aS-(3aa,4b,6aa)]-1H-Thieno[3,4-d]imidazole-4-pentanoic acid","hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-Thieno[3,4-d]imidazole-4-pentanoate","hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-Thieno[3,4-d]imidazole-4-pentanoic acid","Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoate","Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid","Lutavit H2","Meribin","Rovimix H 2","Vitamin B7","Vitamin H","Vitamin-h"],"pathways":[{"name":"Biotin metabolism","kegg_map_id":"00780"},{"name":"Biotin Biosynthesis","kegg_map_id":null},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"Fatty acid biosynthesis","kegg_map_id":"00061"},{"name":"TCA Cycle","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":17259550,"citation":"Muhlenhoff, U., Gerl, M. J., Flauger, B., Pirner, H. M., Balser, S., Richhardt, N., Lill, R., Stolz, J. (2007). \"The ISC [corrected] proteins Isa1 and Isa2 are required for the function but not for the de novo synthesis of the Fe/S clusters of biotin synthase in Saccharomyces cerevisiae.\" Eukaryot Cell 6:495-504."},{"pubmed_id":16269718,"citation":"Wu, H., Ito, K., Shimoi, H. (2005). \"Identification and characterization of a novel biotin biosynthesis gene in Saccharomyces cerevisiae.\" Appl Environ Microbiol 71:6845-6855."},{"pubmed_id":9688262,"citation":"Hoja, U., Wellein, C., Greiner, E., Schweizer, E. (1998). \"Pleiotropic phenotype of acetyl-CoA-carboxylase-defective yeast cells--viability of a BPL1-amber mutation depending on its readthrough by normal tRNA(Gln)(CAG).\" Eur J Biochem 254:520-526."}],"proteins":[{"created_at":"2011-05-26T17:19:36.000Z","updated_at":"2011-07-22T17:54:19.000Z","name":"Biotin synthase, mitochondrial","uniprot_id":"P32451","uniprot_name":"BIOB_YEAST","enzyme":true,"transporter":false,"gene_name":"BIO2","num_residues":375,"molecular_weight":"41883.80078","theoretical_pi":"8.66","general_function":"Involved in catalytic activity","specific_function":"Dethiobiotin + sulfur + 2 S-adenosyl-L- methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine","reactions":[{"id":1347,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2472,"direction":"\u003e","locations":"Mitochondrion","altext":"Dethiobiotin + sulfur + 2 S-adenosyl-L-methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine.","export":false,"pw_reaction_id":null,"source":null},{"id":3756,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006280","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"Z73071","genbank_protein_id":"1323523","gene_card_id":"BIO2","chromosome_location":"chromosome 7","locus":"YGR286C","synonyms":[],"enzyme_classes":["2.8.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring sulfur-containing groups"},{"category":"Function","description":" sulfurtransferase activity"},{"category":"Function","description":" biotin synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" vitamin metabolic process"},{"category":"Process","description":" water-soluble vitamin metabolic process"},{"category":"Process","description":" biotin metabolic process"},{"category":"Process","description":" biotin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" small molecule metabolic process"}],"pfams":[{"name":"Radical_SAM","identifier":"PF04055"},{"name":"BATS","identifier":"PF06968"}],"pathways":[{"name":"Biotin metabolism","kegg_map_id":"00780"},{"name":"Biotin Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGATGTCTACTATCTACCGTCATTTATCTACCGCTAGACCGGCTTTAACTAAATACGCAACCAATGCCGCAGTTAAATCGACAACTGCATCCTCAGAAGCTAGTACTCTGGGTGCTCTACAATATGCATTGTCTTTAGATGAACCAAGTCATTCGTGGACAAAATCGCAATTAAAAGAAATTTATCATACCCCACTGCTCGAACTTACTCATGCAGCACAATTGCAGCACAGAAAGTGGCACGATCCAACCAAAGTGCAATTGTGCACATTGATGAACATCAAATCTGGTGGTTGTTCTGAGGACTGTAAGTATTGTGCGCAGTCTTCGAGAAACGATACCGGTCTAAAGGCTGAGAAAATGGTTAAAGTGGATGAAGTGATTAAAGAGGCAGAAGAGGCCAAAAGAAACGGATCTACTAGATTCTGCCTAGGTGCTGCATGGAGAGACATGAAAGGTCGTAAATCAGCCATGAAAAGAATTCAGGAAATGGTGACCAAAGTGAATGATATGGGGCTAGAAACGTGTGTTACTTTAGGTATGGTTGATCAAGATCAAGCAAAGCAATTGAAAGATGCAGGTTTGACTGCATACAACCATAACATCGACACTTCCAGAGAACACTATAGTAAGGTCATCACCACGAGAACCTACGACGACAGGTTACAGACCATCAAGAATGTCCAAGAATCTGGAATAAAAGCCTGTACCGGTGGTATTTTGGGTCTCGGTGAAAGCGAAGACGACCATATAGGATTCATCTACACATTATCCAATATGTCTCCTCATCCTGAGTCCCTACCAATTAATAGACTAGTTGCTATCAAAGGGACTCCAATGGCTGAGGAACTTGCCGATCCAAAGAGTAAAAAGTTGCAATTCGACGAAATTTTGAGAACCATTGCCACAGCGAGAATAGTTATGCCAAAGGCCATTATAAGACTTGCCGCTGGTCGTTATACAATGAAAGAAACAGAGCAATTTGTCTGTTTCATGGCAGGTTGTAACAGTATCTTCACCGGTAAGAAAATGCTGACGACAATGTGTAACGGTTGGGACGAAGACAAGGCAATGTTGGCTAAATGGGGATTGCAACCTATGGAGGCATTTAAGTACGACAGATCTTGA","protein_sequence":"MMSTIYRHLSTARPALTKYATNAAVKSTTASSEASTLGALQYALSLDEPSHSWTKSQLKEIYHTPLLELTHAAQLQHRKWHDPTKVQLCTLMNIKSGGCSEDCKYCAQSSRNDTGLKAEKMVKVDEVIKEAEEAKRNGSTRFCLGAAWRDMKGRKSAMKRIQEMVTKVNDMGLETCVTLGMVDQDQAKQLKDAGLTAYNHNIDTSREHYSKVITTRTYDDRLQTIKNVQESGIKACTGGILGLGESEDDHIGFIYTLSNMSPHPESLPINRLVAIKGTPMAEELADPKSKKLQFDEILRTIATARIVMPKAIIRLAAGRYTMKETEQFVCFMAGCNSIFTGKKMLTTMCNGWDEDKAMLAKWGLQPMEAFKYDRS"},{"created_at":"2011-05-26T18:43:08.000Z","updated_at":"2011-07-22T17:54:19.000Z","name":"Biotin--protein ligase","uniprot_id":"P48445","uniprot_name":"BPL1_YEAST","enzyme":true,"transporter":false,"gene_name":"BPL1","num_residues":690,"molecular_weight":"76362.39844","theoretical_pi":"6.91","general_function":"Involved in biotin-[acetyl-CoA-carboxylase] ligase activity","specific_function":"Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase","reactions":[{"id":1348,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2547,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] = AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase].","export":false,"pw_reaction_id":null,"source":null},{"id":2548,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)].","export":false,"pw_reaction_id":null,"source":null},{"id":2549,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)].","export":false,"pw_reaction_id":null,"source":null},{"id":2550,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)].","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U27182","genbank_protein_id":"886081","gene_card_id":"BPL1","chromosome_location":"chromosome 4","locus":"YDL141W","synonyms":["Biotin apo-protein ligase","Biotin--[methylmalonyl-CoA-carboxytransferase] ligase","Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase","Holocarboxylase synthetase","HCS","Biotin--[methylcrotonoyl-CoA-carboxylase] ligase","Biotin--[acetyl-CoA-carboxylase] ligase"],"enzyme_classes":["6.3.4.-","6.3.4.9","6.3.4.10","6.3.4.11","6.3.4.15"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" biotin-[acetyl-CoA-carboxylase] ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" biotin-protein ligase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"}],"pfams":[{"name":"BPL_C","identifier":"PF02237"},{"name":"BPL_LipA_LipB","identifier":"PF03099"},{"name":"BPL_N","identifier":"PF09825"}],"pathways":[{"name":"Biotin metabolism","kegg_map_id":"00780"}],"gene_sequence":"ATGAATGTATTAGTCTATAATGGCCCAGGGACTACGCCAGGATCAGTTAAGCATGCTGTTGAAAGTTTACGTGACTTTTTGGAACCCTATTACGCCGTCAGTACTGTCAATGTTAAGGTATTACAGACAGAACCATGGATGTCAAAGACCTCCGCTGTAGTTTTTCCTGGTGGTGCCGATCTTCCTTACGTTCAAGCTTGTCAACCCATTATTTCTCGATTGAAACATTTTGTTAGCAAACAAGGTGGTGTCTTTATCGGATTTTGTGCAGGAGGTTACTTTGGCACCAGCCGTGTAGAATTTGCTCAAGGTGACCCTACAATGGAAGTATCAGGAAGCAGGGATTTGCGATTCTTTCCGGGAACAAGCAGAGGACCTGCGTACAATGGATTTCAGTATAACAGCGAGGCCGGTGCACGTGCAGTTAAATTGAATCTTCCAGATGGCTCACAGTTCTCAACTTATTTCAATGGAGGAGCCGTTTTTGTTGATGCAGATAAATTTGATAATGTCGAGATCTTGGCCACGTACGCAGAACACCCGGATGTGCCTTCTTCTGACTCAGGAAAAGGTCAAAGTGAAAACCCAGCTGCTGTAGTGCTATGTACGGTCGGAAGAGGAAAGGTTTTACTCACTGGACCACACCCTGAATTCAACGTCCGTTTTATGAGGAAATCCACAGATAAGCATTTTCTTGAAACCGTTGTGGAAAACCTGAAAGCACAGGAAATCATGAGGTTGAAATTTATGAGAACGGTTCTTACCAAAACTGGGTTGAATTGTAATAATGACTTCAATTATGTAAGAGCTCCAAATTTGACACCACTGTTTATGGCTAGTGCACCTAATAAGCGGAATTACTTGCAAGAAATGGAAAACAACTTAGCTCATCATGGAATGCATGCAAATAATGTTGAACTCTGCTCAGAATTAAACGCCGAAACTGACTCTTTCCAATTTTATAGAGGCTATAGAGCCTCTTACGATGCAGCAAGTTCGTCCTTGCTTCATAAAGAGCCAGATGAGGTTCCTAAGACCGTAATATTTCCTGGCGTAGATGAAGATATTCCACCATTTCAATATACGCCCAATTTTGACATGAAAGAATACTTCAAGTATCTGAATGTTCAAAACACCATAGGTTCTTTACTTCTATATGGTGAAGTTGTTACATCAACGAGTACCATATTGAATAATAATAAATCCTTATTAAGTTCGATCCCTGAAAGCACTTTACTTCACGTGGGTACTATTCAGGTTTCTGGGCGTGGGAGAGGTGGTAACACTTGGATTAATCCTAAAGGTGTTTGCGCATCAACGGCCGTCGTAACAATGCCGCTTCAATCGCCTGTGACTAATCGAAATATATCAGTTGTTTTTGTCCAGTATCTTTCTATGCTTGCTTACTGTAAGGCGATACTTTCGTACGCTCCTGGATTTTCAGATATTCCTGTTAGGATCAAATGGCCCAATGACCTTTATGCTTTGAGCCCCACCTACTATAAGCGTAAAAACTTGAAATTGGTTAACACCGGTTTTGAGCATACAAAGTTGCCCTTAGGTGATATCGAGCCCGCTTATCTTAAGATCTCTGGTTTATTAGTTAATACCCACTTCATAAACAATAAATATTGTTTGCTACTTGGCTGTGGTATAAATTTGACTAGTGATGGTCCTACAACTTCATTACAAACTTGGATTGATATCCTGAATGAAGAACGCCAACAATTACACCTTGATTTATTGCCAGCAATAAAGGCAGAAAAGCTGCAGGCACTCTATATGAATAACCTTGAGGTCATATTAAAACAGTTTATTAACTACGGAGCTGCGGAAATATTGCCAAGTTATTATGAGTTGTGGTTACATAGTAACCAAATAGTAACATTACCAGATCACGGAAATACGCAAGCCATGATTACTGGTATCACGGAAGACTACGGTTTACTGATTGCAAAAGAATTGGTAAGCGGTAGTTCCACTCAATTTACAGGAAACGTTTATAATTTACAGCCGGACGGTAACACTTTTGATATCTTCAAGAGCTTAATTGCTAAAAAGGTTCAGAGTTAA","protein_sequence":"MNVLVYNGPGTTPGSVKHAVESLRDFLEPYYAVSTVNVKVLQTEPWMSKTSAVVFPGGADLPYVQACQPIISRLKHFVSKQGGVFIGFCAGGYFGTSRVEFAQGDPTMEVSGSRDLRFFPGTSRGPAYNGFQYNSEAGARAVKLNLPDGSQFSTYFNGGAVFVDADKFDNVEILATYAEHPDVPSSDSGKGQSENPAAVVLCTVGRGKVLLTGPHPEFNVRFMRKSTDKHFLETVVENLKAQEIMRLKFMRTVLTKTGLNCNNDFNYVRAPNLTPLFMASAPNKRNYLQEMENNLAHHGMHANNVELCSELNAETDSFQFYRGYRASYDAASSSLLHKEPDEVPKTVIFPGVDEDIPPFQYTPNFDMKEYFKYLNVQNTIGSLLLYGEVVTSTSTILNNNKSLLSSIPESTLLHVGTIQVSGRGRGGNTWINPKGVCASTAVVTMPLQSPVTNRNISVVFVQYLSMLAYCKAILSYAPGFSDIPVRIKWPNDLYALSPTYYKRKNLKLVNTGFEHTKLPLGDIEPAYLKISGLLVNTHFINNKYCLLLGCGINLTSDGPTTSLQTWIDILNEERQQLHLDLLPAIKAEKLQALYMNNLEVILKQFINYGAAEILPSYYELWLHSNQIVTLPDHGNTQAMITGITEDYGLLIAKELVSGSSTQFTGNVYNLQPDGNTFDIFKSLIAKKVQS"},{"created_at":"2011-05-27T06:02:32.000Z","updated_at":"2011-06-05T03:10:10.000Z","name":"Vitamin H transporter","uniprot_id":"P53241","uniprot_name":"VHT1_YEAST","enzyme":false,"transporter":true,"gene_name":"VHT1","num_residues":593,"molecular_weight":"69082.10156","theoretical_pi":"9.07","general_function":"Involved in transmembrane transport","specific_function":"Involved in uptake of biotin with the concomitant entry of protons","reactions":[],"signal_regions":"None","transmembrane_regions":"122-142;167-187;191-211;225-245;292-312;362-382;409-429;433-453;461-481;493-513;527-547","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"Z72850","genbank_protein_id":"1323086","gene_card_id":"VHT1","chromosome_location":"chromosome 7","locus":"YGR065C","synonyms":["H(+)/biotin symporter"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"MFS_1","identifier":"PF07690"}],"pathways":[],"gene_sequence":"ATGACAATTTCGAATAAATCGTGGAGGAGCTACTTCCCACATTTGAGAAAACTACCCGAAGATGATCAGTACTTATACTCAGACGATACTAACTCCAGTATCATAGCTGAAGAGGAGCTACATCATAGCGTAGATAAGTCCTCGAAGACAGACGTTACGGCAGAAACTACAGCTGTAGAACCTCATCCTCACAATTTAAGGCATGACTTGCCATATGAAGTGAGAGATGAAGCTGGGCGTAAATGGTGGAAATATTTTGATGAATTCGAGTATCGTGTTAATAAGGAATACAAGAAATCACGTAAGTGGTACGAGTTTTTGTATCCTAATCATACTACTCAAACCAAGGCTGAAAGACGGCTTCTTTACAAGCTAGACATTATTATTGCTTTATACTTTTTTATGTTATGTTGGTCCAAGTCAGTGGATTTGAATAACTACACTAACGCATATGTTTCCAATATGAAGGAAGATTTAAACATGAAAGGTAATGATTACGTTTACACTTCTACTATTGCTAATGTTGGTGCCATTGTCTTCCAATTACCATTTATGTATTTGTTACCAAGATTTCCCTCTCATATTATTTTGCCTGTAATGGACTTGGGCTGGACTTGGTTCACATTTGCATGTTATAGGGCAAACTCACTAGCCGAACTAAGGGCTTACAGATTTATTTTAAGTGCCTTTGGCGCTGCTTACTACCCAGTGTCCCAATATATACTAGGTTGTTGGTATGCCCCAGATGAAATTAATTCAAGAGTCTGTTTATTCTTTTGTGGGCAACAATTGGGTTCCGTGACTTCAGGACTTCTGCAAAGTCGCATATTCAAAAGTTTGAACGGCGTCCATGGTCTAGCAGGCTGGAGATGGATGTTTCTGATCGATGCCATTGCAATTTCTCTTCCCACGGCTATTATTGGTTTTTTTGTTATTCCCGGTGTACCATCTAAGTGTTACTCTTTATTTCTGACTGACGAAGAAATACGAATTGCAAGGGCCAGAAATAAGAGGAACCAAATCAAAGATGGTGTTGATAAAAGTAAGCTAGCCCCATTATGGAGCAGAAAACTTTGGAAGAAAGTATTTTGTACTCCAGCATTCTGGGTACTTGTTGTTTTTGATACATGTTCGTGGAATAACATGACTGCGTATAGTGGTTCATATACTTTGTGGTTAAAGTCTAATACAAAGTACTCCATTGCCCAAGTGAACAACCTGAGTGTTATACCCGCATGTTTAGGATTTGCGTATGTGATTTTTTGTGCCTTTGGTGCCGATTTATTTAGATGTAAGTGGATATTCATGGTTTTTGCTGCTATAATGAATACCGTTTCTTGTGCCTTACTTATCAAGTGGGATATTCCTTCGAAAGCTAAATGGTACGCTTTCTTCACCACGTATTTCAGTGTGGCCGCATCGCCTTGTCTATGGTCGTTTATTAATGACTTCTTAAGGTTTGATCCTCAGGTGAAGGCTATTACATGGATCGCCATTTATTCCTTCTCTCAATCCACTTACGCCTGGATTCCTACCTTGGCGTGGCCTACCGTGGAGTCACCACGTTTTAAGACTGGTTACACCGTGAGCTTAATTTTTGGTGCTATTTACGGTTTATGGACGTTTGTTGTACTTTTTTTTTACAAGAGAAACGAAAAGAAACATGCTCTAGGTAATGGTATCATCTTGTATGATAGTAATAAGGGTGAAGAGCTTCCAGAATTTGTAAAGAAAAATATGGAGGAAAGAGATGGTTACTACTATTTAAAGCGGTCCTCGTAG","protein_sequence":"MTISNKSWRSYFPHLRKLPEDDQYLYSDDTNSSIIAEEELHHSVDKSSKTDVTAETTAVEPHPHNLRHDLPYEVRDEAGRKWWKYFDEFEYRVNKEYKKSRKWYEFLYPNHTTQTKAERRLLYKLDIIIALYFFMLCWSKSVDLNNYTNAYVSNMKEDLNMKGNDYVYTSTIANVGAIVFQLPFMYLLPRFPSHIILPVMDLGWTWFTFACYRANSLAELRAYRFILSAFGAAYYPVSQYILGCWYAPDEINSRVCLFFCGQQLGSVTSGLLQSRIFKSLNGVHGLAGWRWMFLIDAIAISLPTAIIGFFVIPGVPSKCYSLFLTDEEIRIARARNKRNQIKDGVDKSKLAPLWSRKLWKKVFCTPAFWVLVVFDTCSWNNMTAYSGSYTLWLKSNTKYSIAQVNNLSVIPACLGFAYVIFCAFGADLFRCKWIFMVFAAIMNTVSCALLIKWDIPSKAKWYAFFTTYFSVAASPCLWSFINDFLRFDPQVKAITWIAIYSFSQSTYAWIPTLAWPTVESPRFKTGYTVSLIFGAIYGLWTFVVLFFYKRNEKKHALGNGIILYDSNKGEELPEFVKKNMEERDGYYYLKRSS"}]}