{"ymdb_id":"YMDB00271","created_at":"2011-05-29T18:00:46.000Z","updated_at":"2016-10-18T17:11:24.000Z","name":"L-Glutamic acid","cas":"56-86-0","state":"Solid","melting_point":"224 oC","description":"Glutamate (abbreviated as Glu or E) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a polar, acidic (pKa = 4.3) amino acid with a side chain carboxylic acid. Glutamic acid and alpha-ketoglutarate, an intermediate in the Krebs cycle, are interconvertible by transamination. Glutamic acid can therefore enter the Krebs cycle for energy metabolism, and be converted by the enzyme glutamine synthetase into glutamine, which is one of the key players in nitrogen metabolism. Note also that glutamic acid is easily converted into proline. First, the γ carboxyl group is reduced to the aldehyde, yielding glutamate semialdehyde. The aldehyde then reacts with the alpha-amino group, eliminating water as it forms the Schiff base. In a second reduction step, the Schiff base is reduced, yielding proline. Yeast cells contain 3 pathways for the synthesis of glutamate. Two pathways are mediated by two isoforms of glutamate dehydrogenase, encoded by GDH1 and GDH3. The third pathway is driven by the combined activities of glutamine synthetase and glutamate synthase, encoded by GLN1 and GLT1, respectively. Studies of GDH1 and GDH3 regulation indicate that the cell uses these isoforms under different growth conditions. Expression of GDH3 is induced by ethanol and repressed by glucose, whereas GDH1 expression is high in either carbon source. Gdh1p uses alpha-ketoglutarate at a higher rate than Gdh3p. Thus, under fermentative growth conditions, Gdh1p drives glutamate biosynthesis, whereas in nonfermentable or limiting carbon sources, Gdh3p is the key isoform involved in balancing distribution of alpha-ketoglutarate to glutamate biosynthesis and energy metabolism. Free glutamic acid is present in a wide variety of foods, including cheese and soy sauce, and is responsible for umami, one of the five basic tastes of the human sense of taste. Glutamic acid is often used as a food additive and flavour enhancer in the form of its sodium salt monosodium glutamate (MSG).","experimental_water_solubility":"8.57 mg/mL at 25 oC [BULL,HB et al. (1978)]","experimental_logp_hydrophobicity":"-3.69 [HANSCH,C ET AL. (1995)]","location":"extracellular;mitochondrion;nucleus;peroxisome;vacuole;cytoplasm","synthesis_reference":" Horner, L.; Gross, A. Tertiary phosphines. IV. Use of phosphine imines in causing the introduction of primary amino groups. Ann. (1955), 591 117-34.","chebi_id":"16015","hmdb_id":"HMDB00148","kegg_id":"C00025","pubchem_id":"33032","cs_id":"30572","foodb_id":null,"wikipedia_link":"Glutamic_acid","biocyc_id":"GLT","iupac":"(2S)-2-aminopentanedioic acid","traditional_iupac":"L-glutamic acid","logp":"-3.241447075983049","pka":"4.27124634014693","alogps_solubility":"8.06e+01 g/l","alogps_logp":"-3.54","alogps_logs":"-0.26","acceptor_count":"5","donor_count":"3","rotatable_bond_count":"4","polar_surface_area":"100.61999999999999","refractivity":"31.287699999999997","polarizability":"13.321186860931029","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"9.536217151721162","pka_strongest_acidic":"1.8777772810395925","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2S)-2-Aminopentanedioate","(2S)-2-Aminopentanedioic acid","(2S)-2-ammoniopentanedioate","(S)-(+)-Glutamate","(S)-(+)-Glutamic acid","(S)-2-Aminopentanedioate","(S)-2-Aminopentanedioic acid","(S)-Glutamate","(S)-Glutamic acid","1-amino-propane-1,3-dicarboxylate","1-amino-propane-1,3-dicarboxylic acid","1-Aminopropane-1,3-dicarboxylate","1-Aminopropane-1,3-dicarboxylic acid","2-Aminoglutarate","2-Aminoglutaric acid","2-Aminopentanedioate","2-Aminopentanedioic acid","a-Aminoglutarate","a-Aminoglutaric acid","a-Glutamate","a-Glutamic acid","Aciglut","alpha-Aminoglutarate","alpha-Aminoglutaric acid","alpha-Glutamate","alpha-Glutamic acid","aminoglutarate","aminoglutaric acid","glt","glu","Glusate","glut","Glutacid","Glutamicol","Glutamidex","Glutaminate","Glutaminic acid","Glutaminol","Glutaton","L-(+)-Glutamate","L-(+)-Glutamic acid","L-a-Aminoglutarate","L-a-Aminoglutaric acid","L-alpha-Aminoglutarate","L-alpha-Aminoglutaric acid","L-glu","L-Glutamate","L-glutamate(1-)","L-glutamic acid monoanion","L-glutamic acid, ion(1-)","L-Glutaminate","L-Glutaminic acid"],"pathways":[{"name":"Taurine and hypotaurine metabolism","kegg_map_id":"00430"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"4-aminobutanoate degradation","kegg_map_id":null},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Asparagine metabolism","kegg_map_id":null},{"name":"Aspartate metabolism","kegg_map_id":null},{"name":"Glutamate Metabolism","kegg_map_id":null},{"name":"Histidine Biosynthesis","kegg_map_id":null},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"L-alanine metabolism","kegg_map_id":null},{"name":"Leucine Biosynthesis","kegg_map_id":null},{"name":"Leucine Degradation","kegg_map_id":null},{"name":"NAD metabolism","kegg_map_id":null},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Proline Metabolism","kegg_map_id":null},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Valine Biosynthesis","kegg_map_id":null},{"name":"Valine Degradation","kegg_map_id":null},{"name":"Vitamin B6","kegg_map_id":null},{"name":"glycine metabolism","kegg_map_id":null},{"name":"isoleucine biosynthesis","kegg_map_id":null},{"name":"lysine metabolism","kegg_map_id":null},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"serine metabolism","kegg_map_id":null},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"growth_conditions":[{"growth_media":"YPD media","concentration":"36179.80513","concentration_units":"\u0026#181;M","error":"723.66154"},{"growth_media":"YPG media","concentration":"45939.27179","concentration_units":"\u0026#181;M","error":"918.77949"},{"growth_media":"SD media","concentration":"12199.33333","concentration_units":"\u0026#181;M","error":"243.89744"},{"growth_media":"SG media","concentration":"30811.97949","concentration_units":"\u0026#181;M","error":"616.28718"},{"growth_media":"M (molasses)","concentration":"21052.51282","concentration_units":"\u0026#181;M","error":"421.16923"},{"growth_media":"MA (molasses)","concentration":"47472.85128","concentration_units":"\u0026#181;M","error":"949.41538"},{"growth_media":"MB (molasses)","concentration":"14848.29744","concentration_units":"\u0026#181;M","error":"296.84103"},{"growth_media":"MAB (molasses)","concentration":"56326.03077","concentration_units":"\u0026#181;M","error":"1126.38974"},{"growth_media":"hops, malted barley","concentration":"3194.0","concentration_units":"\u0026#181;M","error":"0.0"},{"growth_media":"Synthetic medium with 20 g/L glucose","concentration":"81470.0","concentration_units":"\u0026#181;M","error":"7495.0"},{"growth_media":"Minimal medium supplemented with glucose","concentration":"42500.0","concentration_units":"\u0026#181;M","error":"7500.0"},{"growth_media":"Minimal medium  supplemented with ammonium and glucose","concentration":"37500.0","concentration_units":"\u0026#181;M","error":"12500.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"170.0","concentration_units":"umol/g DW","error":"0.0"}],"references":[{"pubmed_id":7654310,"citation":"Martinez-Force, E., Benitez, T. (1995). \"Effects of varying media, temperature, and growth rates on the intracellular concentrations of yeast amino acids.\" Biotechnol Prog 11:386-392."},{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10509015,"citation":"Arevalo-Rodriguez, M., Calderon, I. L., Holmberg, S. (1999). \"Mutations that cause threonine sensitivity identify catalytic and regulatory regions of the aspartate kinase of Saccharomyces cerevisiae.\" Yeast 15:1331-1345."},{"pubmed_id":12902239,"citation":"Vuralhan, Z., Morais, M. A., Tai, S. L., Piper, M. D., Pronk, J. T. (2003). \"Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae.\" Appl Environ Microbiol 69:4534-4541."},{"pubmed_id":3933486,"citation":"Takada, Y., Noguchi, T. (1985). \"Characteristics of alanine: glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates.\" Biochem J 231:157-163."},{"pubmed_id":null,"citation":"Alcoholic beverage, beer, regular, all - U.S. Department of Agriculture, Agricultural Research Service. 2010. USDA National Nutrient Database for Standard Reference, Release 23. \u003ca href = http://www.ars.usda.gov/ba/bhnrc/ndl\u003eNutrient Data Laboratory Home Page\u003c/a\u003e"},{"pubmed_id":12584756,"citation":"Hans, M. A., Heinzle, E., Wittmann, C. (2003). \"Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.\" Biotechnol Bioeng 82:143-151."},{"pubmed_id":9341119,"citation":"Dickinson, J. R., Lanterman, M. M., Danner, D. J., Pearson, B. M., Sanz, P., Harrison, S. J., Hewlins, M. J. (1997). \"A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae.\" J Biol Chem 272:26871-26878."},{"pubmed_id":14622413,"citation":"Cavero, S., Vozza, A., del Arco, A., Palmieri, L., Villa, A., Blanco, E., Runswick, M. J., Walker, J. E., Cerdan, S., Palmieri, F., Satrustegui, J. (2003). \"Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae.\" Mol Microbiol 50:1257-1269."},{"pubmed_id":8001582,"citation":"Crombie, T., Boyle, J. P., Coggins, J. R., Brown, A. J. (1994). \"The folding of the bifunctional TRP3 protein in yeast is influenced by a translational pause which lies in a region of structural divergence with Escherichia coli indoleglycerol-phosphate synthase.\" Eur J Biochem 226:657-664."},{"pubmed_id":14554197,"citation":"Moreira dos Santos, M., Thygesen, G., Kotter, P., Olsson, L., Nielsen, J. (2003). \"Aerobic physiology of redox-engineered Saccharomyces cerevisiae strains modified in the ammonium assimilation for increased NADPH availability.\" FEMS Yeast Res 4:59-68."},{"pubmed_id":2656689,"citation":"Watzele, G., Tanner, W. (1989). \"Cloning of the glutamine:fructose-6-phosphate amidotransferase gene from yeast. Pheromonal regulation of its transcription.\" J Biol Chem 264:8753-8758."},{"pubmed_id":9288922,"citation":"Verleur, N., Elgersma, Y., Van Roermund, C. W., Tabak, H. F., Wanders, R. J. (1997). \"Cytosolic aspartate aminotransferase encoded by the AAT2 gene is targeted to the peroxisomes in oleate-grown Saccharomyces cerevisiae.\" Eur J Biochem 247:972-980."},{"pubmed_id":8017107,"citation":"Belhumeur, P., Fortin, N., Clark, M. W. (1994). \"A gene from Saccharomyces cerevisiae which codes for a protein with significant homology to the bacterial 3-phosphoserine aminotransferase.\" Yeast 10:385-389."},{"pubmed_id":9611819,"citation":"ter Schure, E. G., Sillje, H. H., Vermeulen, E. E., Kalhorn, J. W., Verkleij, A. J., Boonstra, J., Verrips, C. T. (1998). \"Repression of nitrogen catabolic genes by ammonia and glutamine in nitrogen-limited continuous cultures of Saccharomyces cerevisiae.\" Microbiology 144 ( Pt 5):1451-1462."},{"pubmed_id":8798704,"citation":"Kispal, G., Steiner, H., Court, D. A., Rolinski, B., Lill, R. (1996). \"Mitochondrial and cytosolic branched-chain amino acid transaminases from yeast, homologs of the myc oncogene-regulated Eca39 protein.\" J Biol Chem 271:24458-24464."},{"pubmed_id":11731153,"citation":"Bayly, A. M., Berglez, J. M., Patel, O., Castelli, L. A., Hankins, E. G., Coloe, P., Hopkins Sibley, C., Macreadie, I. G. (2001). \"Folic acid utilisation related to sulfa drug resistance in Saccharomyces cerevisiae.\" FEMS Microbiol Lett 204:387-390."},{"pubmed_id":3123231,"citation":"Ramos, F., Dubois, E., Pierard, A. (1988). \"Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14.\" Eur J Biochem 171:171-176."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."},{"pubmed_id":10799479,"citation":"Cherest, H., Thomas, D., Surdin-Kerjan, Y. (2000). \"Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae.\" J Biol Chem 275:14056-14063."},{"pubmed_id":9748245,"citation":"Dickinson, J. R., Harrison, S. J., Hewlins, M. J. (1998). \"An investigation of the metabolism of valine to isobutyl alcohol in Saccharomyces cerevisiae.\" J Biol Chem 273:25751-25756."},{"pubmed_id":7607232,"citation":"Tzagoloff, A., Shtanko, A. (1995). \"Mitochondrial and cytoplasmic isoleucyl-, glutamyl- and arginyl-tRNA synthetases of yeast are encoded by separate genes.\" Eur J Biochem 230:582-586."},{"pubmed_id":9491083,"citation":"Iraqui, I., Vissers, S., Cartiaux, M., Urrestarazu, A. (1998). \"Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily.\" Mol Gen Genet 257:238-248."},{"pubmed_id":9657994,"citation":"Valenzuela, L., Ballario, P., Aranda, C., Filetici, P., Gonzalez, A. (1998). \"Regulation of expression of GLT1, the gene encoding glutamate synthase in Saccharomyces cerevisiae.\" J Bacteriol 180:3533-3540."},{"pubmed_id":387737,"citation":"Brandriss, M. C., Magasanik, B. (1979). \"Genetics and physiology of proline utilization in Saccharomyces cerevisiae: enzyme induction by proline.\" J Bacteriol 140:498-503."},{"pubmed_id":11031268,"citation":"Coleman, S. T., Fang, T. K., Rovinsky, S. A., Turano, F. J., Moye-Rowley, W. S. (2001). \"Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae.\" J Biol Chem 276:244-250."},{"pubmed_id":4578278,"citation":"Gancedo, J. M., Gancedo, C. (1973). \"Concentrations of intermediary metabolites in yeast.\" Biochimie 55:205-211."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T19:21:34.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"Phosphoribosylformylglycinamidine synthase","uniprot_id":"P38972","uniprot_name":"PUR4_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE6","num_residues":1358,"molecular_weight":"148904.0","theoretical_pi":"4.92","general_function":"Involved in catalytic activity","specific_function":"ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate","reactions":[{"id":1889,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2248,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z72846","genbank_protein_id":"1323079","gene_card_id":"ADE6","chromosome_location":"chromosome 7","locus":"YGR061C","synonyms":["FGAM synthase","FGAMS","Formylglycinamide ribotide amidotransferase","FGARAT","Formylglycinamide ribotide synthetase"],"enzyme_classes":["6.3.5.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" phosphoribosylformylglycinamidine synthase activity"},{"category":"Process","description":" IMP biosynthetic process"},{"category":"Process","description":" 'de novo' IMP biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"}],"pfams":[{"name":"AIRS","identifier":"PF00586"},{"name":"AIRS_C","identifier":"PF02769"}],"pathways":[{"name":"Purine 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FNTSKTWTPLLNRNTDDSVLVLVDLSAKQETKSLGASALLQVYNQVGNKSPTVYDNAILKGFLESLIQLHQQKEDIVLAYHDRSDGGLLITLLEMAFASRCGLEINIDGGDLESQLTNLFNEELGAVFQISAKNLSKFEKILNENGVAKEYISIVGKPSFQSQEIKIINSTTNDVIYANSRSELEQTWSKTSYEMQKLRDNPKTAEEEFASITDDRDPGLQYALTYNPADDMKIGLELSSQRPKVAILREQGVNGQMEMAWCFQQAGFNSVDVTMTDLLEGRFHLDDFIGLAACGGFSYGDVLGAGAGWAKSVLYHEGVRSQFSKFFNERQDTFAFGACNGCQFLSRLKDIIPGCENWPSFERNVSEQYEARVCMVQISQEKDNSSEESVFLNGMAGSKLPIAVAHGEGKATFSKSAEQLEKFEKDGLCCIRYVDNYGNVTERFPFNPNGSTNGIAGIKSPNGRVLAMMPHPERVCRLEANSWYPEGKYEEWGGYGPWIRLFRSARRWVG"},{"created_at":"2011-05-24T19:22:35.000Z","updated_at":"2011-05-24T19:22:35.000Z","name":"Putative glucosamine--fructose-6-phosphate aminotransferase [isomerizing]","uniprot_id":"A2P2R3","uniprot_name":"YM084_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":262,"molecular_weight":"29272.0","theoretical_pi":"6.17","general_function":"Involved in metabolic process","specific_function":"Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins)","reactions":[{"id":2250,"direction":"\u003e","locations":"","altext":"L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY692572","genbank_protein_id":"51012595","gene_card_id":null,"chromosome_location":null,"locus":"YMR084W","synonyms":["GFAT","D-fructose-6-phosphate amidotransferase","Hexosephosphate aminotransferase"],"enzyme_classes":["2.6.1.16"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"GATase_2","identifier":"PF00310"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Amino sugar and nucleotide sugar 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synthase component 2","uniprot_id":"P00937","uniprot_name":"TRPG_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP3","num_residues":484,"molecular_weight":"53488.89844","theoretical_pi":"6.91","general_function":"Involved in catalytic activity","specific_function":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate","reactions":[{"id":1657,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2251,"direction":"\u003e","locations":"","altext":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2252,"direction":"\u003e","locations":null,"altext":"1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":14103,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006527","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"K01386","genbank_protein_id":"173045","gene_card_id":"TRP3","chromosome_location":"chromosome 11","locus":"YKL211C","synonyms":["Anthranilate synthase component II","Glutamine amidotransferase","Indole-3-glycerol phosphate synthase","PRAI"],"enzyme_classes":["4.1.3.27","4.1.1.48"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" anthranilate synthase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" indole-3-glycerol-phosphate synthase activity"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"IGPS","identifier":"PF00218"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGTCTGTGCACGCTGCAACAAACCCAATCAATAAGCATGTGGTTCTAATTGACAACTACGATTCCTTTACCTGGAACGTTTACGAGTACTTGTGCCAGGAGGGCGCCAAAGTGAGCGTCTACCGTAACGATGCAATTACAGTTCCAGAAATTGCCGCCTTGAATCCCGACACATTGCTTATCTCGCCTGGACCAGGCCACCCAAAGACAGATTCTGGCATTTCAAGAGACTGTATCCGGTACTTTACTGGGAAAATTCCTGTATTTGGAATCTGTATGGGCCAGCAATGCATGTTTGACGTATTTGGTGGTGAAGTTGCCTACGCTGGTGAGATTGTCCACGGTAAAACGTCCCCAATCTCTCACGACAACTGTGGAATTTTCAGGAACGTGCCGCAAGGTATTGCTGTGACAAGATACCATTCATTGGCCGGGACAGAATCGTCCCTACCATCCTGCTTGAAGGTTACTGCGAGTACCGAAAATGGAATTATCATGGGTGTAAGACACAAGAAGTACACTGTAGAAGGTGTGCAATTTCATCCGGAATCCATCTTGACCGAGGAAGGTCATCTGATGATCAGGAACATTTTAAACGTCAGTGGAGGCACTTGGGAGGAAAACAAATCATCTCCTTCAAATTCTATTTTGGACCGTATCTATGCTCGGCGTAAAATAGACGTCAATGAGCAGTCTAAAATCCCAGGTTTCACCTTTCAAGACTTACAATCTAACTATGATTTAGGTCTTGCCCCACCGTTACAGGATTTCTACACGGTGTTGTCATCATCCCATAAAAGAGCCGTTGTTCTTGCTGAAGTCAAGCGTGCCTCTCCATCGAAGGGACCCATTTGTTTAAAAGCTGTTGCTGCTGAACAGGCTCTCAAATACGCAGAGGCTGGTGCATCCGCAATTTCCGTATTGACCGAACCTCATTGGTTTCACGGTTCGTTACAGGATTTAGTAAATGTGAGGAAAATCCTAGATTTGAAATTTCCTCCCAAGGAGAGGCCTTGTGTTTTGAGAAAAGAATTTATTTTCAGCAAGTATCAAATACTAGAAGCAAGATTAGCTGGAGCTGACACTGTCCTTCTTATAGTCAAGATGCTATCTCAACCCTTATTGAAGGAACTGTACAGCTACAGTAAAGATTTGAACATGGAACCTCTCGTTGAGGTGAACTCCAAAGAGGAATTACAAAGGGCTCTAGAAATTGGTGCTAAAGTTGTAGGTGTCAATAATAGGGACCTGCATTCATTCAACGTAGACCTAAATACCACCAGTAACTTGGTAGAATCTATTCCAAAGGATGTTCTTCTAATTGCTCTATCGGGAATTACCACCAGGGACGATGCTGAAAAATACAAAAAAGAAGGTGTCCATGGATTTTTAGTGGGTGAAGCCCTAATGAAATCAACCGATGTGAAGAAGTTCATTCATGAATTATGCGAATAA","protein_sequence":"MSVHAATNPINKHVVLIDNYDSFTWNVYEYLCQEGAKVSVYRNDAITVPEIAALNPDTLLISPGPGHPKTDSGISRDCIRYFTGKIPVFGICMGQQCMFDVFGGEVAYAGEIVHGKTSPISHDNCGIFKNVPQGIAVTRYHSLAGTESSLPSCLKVTASTENGIIMGVRHKKYTVEGVQFHPESILTEEGHLMIRNILNVSGGTWEENKSSPSNSILDRIYARRKIDVNEQSKIPGFTFQDLQSNYDLGLAPPLQDFYTVLSSSHKRAVVLAEVKRASPSKGPICLKAVAAEQALKYAEAGASAISVLTEPHWFHGSLQDLVNVRKILDLKFPPKERPCVLRKEFIFSKYQILEARLAGADTVLLIVKMLSQPLLKELYSYSKDLNMEPLVEVNSKEELQRALEIGAKVVGVNNRDLHSFNVDLNTTSNLVESIPKDVLLIALSGITTRDDAEKYKKEGVHGFLVGEALMKSTDVKKFIHELCE"},{"created_at":"2011-05-24T19:24:00.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]","uniprot_id":"P14742","uniprot_name":"GFA1_YEAST","enzyme":true,"transporter":false,"gene_name":"GFA1","num_residues":717,"molecular_weight":"80046.0","theoretical_pi":"6.4","general_function":"Involved in metabolic process","specific_function":"Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins)","reactions":[{"id":1580,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2250,"direction":"\u003e","locations":"","altext":"L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4133,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006428","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X71133","genbank_protein_id":"431212","gene_card_id":"GFA1","chromosome_location":"chromosome 11","locus":"YKL104C","synonyms":["GFAT","D-fructose-6-phosphate amidotransferase","Hexosephosphate aminotransferase"],"enzyme_classes":["2.6.1.16"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" carbohydrate binding"},{"category":"Function","description":" sugar binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" glutamine-fructose-6-phosphate transaminase (isomerizing) activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" carbohydrate biosynthetic process"}],"pfams":[{"name":"GATase_2","identifier":"PF00310"},{"name":"SIS","identifier":"PF01380"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGTGTGGTATCTTTGGTTACTGCAATTATCTAGTGGAAAGATCCAGAGGAGAAATTATCGACACCTTAGTGGATGGTTTACAAAGATTAGAATATAGAGGCTATGATTCCACCGGTATTGCTATCGATGGTGACGAAGCTGATTCTACTTTCATCTATAAGCAAATCGGTAAAGTGAGTGCTTTGAAAGAGGAGATTACTAAGCAAAATCCGAACAGAGACGTTACTTTTGTCTCTCATTGTGGTATTGCGCATACTAGATGGGCTACTCACGGTCGACCAGAACAAGTTAACTGTCACCCTCAAAGATCTGACCCAGAAGACCAATTTGTGGTCGTTCATAATGGTATCATCACAAATTTTAGAGAACTGAAGACTCTTTTAATTAACAAAGGTTATAAATTCGAAAGTGATACCGATACCGAGTGTATTGCTAAACTATATTTGCATTTATACAATACAAATTTACAAAATGGGCATGACTTAGATTTCCACGAATTAACCAAGCTAGTTCTTTTAGAACTAGAAGGTTCATACGGGTTATTATGTAAATCTTGTCACTATCCTAATGAGGTTATCGCCACTAGAAAAGGGTCCCCTTTACTGATTGGTGTCAAATCTGAAAAAAAACTAAAAGTCGACTTCGTGGATGTGGAATTTCCCGAAGAAAACGCTGGTCAACCGGAAATTCCATTGAAATCTAACAACAAATCATTTGGCTTGGGCCCAAAGAAAGCTCGTGAATTTGAAGCTGGTTCCCAAAATGCCAATTTACTACCAATTGCCGCCAATGAATTTAACTTGAGACATTCTCAATCCAGGGCTTTCCTATCAGAAGATGGATCTCCAACACCGGTGGAATTTTTTGTTTCTTCGGATGCGGCATCTGTTGTTAAACATACCAAGAAGGTGCTATTTTTAGAAGATGACGATTTGGCTCATATTTACGATGGTGAGTTACATATTCATAGATCTAGAAGAGAAGTAGGCGCATCAATGACAAGGTCCATTCAAACTTTAGAGATGGAGTTAGCTCAGATCATGAAGGGCCCTTACGACCATTTTATGCAAAAGGAAATCTATGAGCAACCAGAATCTACTTTCAATACTATGAGAGGTAGAATCGACTATGAAAATAATAAAGTGATATTGGGTGGTTTAAAGGCATGGTTACCAGTTGTCAGAAGAGCACGGAGACTGATCATGATCGCATGCGGTACTTCTTATCATTCATGTTTGGCTACTCGTGCTATCTTCGAAGAATTATCAGATATCCCAGTTAGTGTGGAATTAGCGTCTGACTTTCTGGACAGAAAATGCCCTGTCTTCAGAGACGATGTATGCGTGTTTGTTTCACAAAGTGGTGAAACTGCGGATACCATGCTGGCTCTAAATTATTGTTTAGAAAGAGGAGCCTTAACTGTCGGAATTGTTAACAGTGTTGGTTCTTCTATCTCTCGTGTCACCCACTGTGGTGTTCATATTAACGCTGGTCCTGAAATTGGTGTTGCCTCTACAAAAGCTTATACTTCCCAGTATATTGCCTTAGTGATGTTTGCTCTATCGCTGTCAGATGACCGTGTATCGAAAATAGACAGAAGAATTGAAATCATTCAAGGCTTGAAGTTAATCCCGGGCCAAATTAAGCAGGTATTAAAGCTGGAACCAAGAATAAAAAAGCTCTGTGCGACTGAATTAAAGGATCAAAAATCTCTATTGTTATTGGGTAGAGGTTACCAATTTGCTGCTGCTCTGGAAGGTGCTTTGAAGATCAAAGAAATTTCTTATATGCATTCTGAAGGTGTTTTGGCAGGTGAGTTGAAGCACGGTGTCTTGGCCTTGGTGGACGAAAACTTGCCAATCATTGCTTTTGGTACCAGAGACTCTCTATTCCCTAAAGTAGTTTCCTCTATTGAGCAAGTTACTGCAAGAAAGGGCCATCCAATTATTATTTGTAACGAAAATGATGAAGTGTGGGCGCAAAAATCTAAATCAATCGACCTGCAAACCTTAGAAGTTCCACAAACTGTTGATTGTTTACAAGGTCTAATTAATATTATTCCATTACAACTAATGTCATATTGGTTGGCTGTTAATAAAGGGATTGATGTTGATTTTCCAAGAAACTTGGCTAAATCTGTTACCGTCGAATAA","protein_sequence":"MCGIFGYCNYLVERSRGEIIDTLVDGLQRLEYRGYDSTGIAIDGDEADSTFIYKQIGKVSALKEEITKQNPNRDVTFVSHCGIAHTRWATHGRPEQVNCHPQRSDPEDQFVVVHNGIITNFRELKTLLINKGYKFESDTDTECIAKLYLHLYNTNLQNGHDLDFHELTKLVLLELEGSYGLLCKSCHYPNEVIATRKGSPLLIGVKSEKKLKVDFVDVEFPEENAGQPEIPLKSNNKSFGLGPKKAREFEAGSQNANLLPIAANEFNLRHSQSRAFLSEDGSPTPVEFFVSSDAASVVKHTKKVLFLEDDDLAHIYDGELHIHRSRREVGASMTRSIQTLEMELAQIMKGPYDHFMQKEIYEQPESTFNTMRGRIDYENNKVILGGLKAWLPVVRRARRLIMIACGTSYHSCLATRAIFEELSDIPVSVELASDFLDRKCPVFRDDVCVFVSQSGETADTMLALNYCLERGALTVGIVNSVGSSISRVTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSDDRVSKIDRRIEIIQGLKLIPGQIKQVLKLEPRIKKLCATELKDQKSLLLLGRGYQFAAALEGALKIKEISYMHSEGVLAGELKHGVLALVDENLPIIAFGTRDSLFPKVVSSIEQVTARKGHPIIICNENDEVWAQKSKSIDLQTLEVPQTVDCLQGLINIIPLQLMSYWLAVNKGIDVDFPRNLAKSVTVE"},{"created_at":"2011-05-24T19:26:20.000Z","updated_at":"2011-05-29T05:06:11.000Z","name":"Carbamoyl-phosphate synthase arginine-specific small chain","uniprot_id":"P07258","uniprot_name":"CARA_YEAST","enzyme":true,"transporter":false,"gene_name":"CPA1","num_residues":411,"molecular_weight":"45361.19922","theoretical_pi":"7.32","general_function":"Involved in catalytic activity","specific_function":"2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate","reactions":[{"id":2254,"direction":"\u003e","locations":"Cytoplasm","altext":"2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"K02132","genbank_protein_id":"171305","gene_card_id":"CPA1","chromosome_location":"chromosome 15","locus":"YOR303W","synonyms":["CPS-A","Arginine-specific carbamoyl-phosphate synthetase, glutamine chain"],"enzyme_classes":["6.3.5.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbamoyl-phosphate synthase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamine metabolic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"CPSase_sm_chain","identifier":"PF00988"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGTCCTCCGCTGCAACAAAAGCTACTTTCTGTATTCAAAATGGTCCTTCCTTTGAAGGTATATCTTTTGGTGCAAACAAATCTGTTGCTGGTGAAACAGTTTTCACTACTTCTCTGGTTGGTTACCCAGAGTCCATGACTGATCCTTCCTACCGTGGTCAGATATTAGTCTTCACGCAACCCTTGATTGGTAACTACGGTGTCCCATCCGGCGAAGCCCGCGATGAATACAATTTACTGAAGTATTTTGAATCTCCGCATATACATGTGGTCGGCATCGTTGTCGCTGAATATGCTTATCAATATTCGCATTGGACCGCTGTTGAATCTCTGGCACAATGGTGTCAGAGAGAAGGTGTTGCTGCTATTACTGGCGTAGACACCCGTGAACTAGTGCAATACTTGAGGGAACAAGGTTCTTCTTTGGGCCGTATTACGTTGGCTGATCATGACCCTGTCCCCTACGTGAATCCCATGAAAACTAACTTGGTTGCTCAAGTCACCACAAAAAAGCCTTTCCACGTCTCTGCCTTACCTGGGAAGGCTAAGGCAAATGTGGCTCTTATTGACTGTGGTGTTAAAGAAAACATTATCAGATGCCTAGTCAAAAGAGGTGCCAATGTAACTGTTTTCCCCTATGATTACAGAATTCAAGATGTTGCTTCTGAATTCGACGGTATTTTCTTATCCAATGGACCAGGCAACCCAGAACTATGCCAAGCTACAATTTCCAACGTCAGGGAATTACTAAATAACCCTGTTTATGACTGTATCCCTATTTTTGGGATTTGTCTAGGCCATCAACTCTTGGCTCTGGCCTCCGGTGCCTCTACTCACAAATTGAAATATGGTAATAGGGCTCACAACATCCCTGCCATGGATTTGACTACCGGCCAGTGCCACATTACATCTCAAAATCATGGCTATGCAGTTGATCCTGAGACCCTACCAAAGGACCAATGGAAACCTTATTTTGTTAATTTAAACGACAAATCAAACGAAGGCATGATACACCTTCAAAGACCCATATTTTCTACCCAATTTCACCCAGAGGCAAAAGGTGGTCCCTTAGACACAGCTATTCTTTTTGACAAATTCTTCGATAATATAGAAAAATACCAATTACAATCTCAGGCAAAAAGTTCAATCTCACTAAAAGTAACATACAGTACCGATAAATCGAGATTGCAGAGTATAAATGTTACTAAGTTGGCCAAGGAAAGAGTGTTGTTCTAA","protein_sequence":"MSSAATKATFCIQNGPSFEGISFGANKSVAGETVFTTSLVGYPESMTDPSYRGQILVFTQPLIGNYGVPSGEARDEYNLLKYFESPHIHVVGIVVAEYAYQYSHWTAVESLAQWCQREGVAAITGVDTRELVQYLREQGSSLGRITLADHDPVPYVNPMKTNLVAQVTTKKPFHVSALPGKAKANVALIDCGVKENIIRCLVKRGANVTVFPYDYRIQDVASEFDGIFLSNGPGNPELCQATISNVRELLNNPVYDCIPIFGICLGHQLLALASGASTHKLKYGNRAHNIPAMDLTTGQCHITSQNHGYAVDPETLPKDQWKPYFVNLNDKSNEGMIHLQRPIFSTQFHPEAKGGPLDTAILFDKFFDNIEKYQLQSQAKSSISLKVTYSTDKSRLQSINVTKLAKERVLF"},{"created_at":"2011-05-24T19:27:04.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Imidazole glycerol phosphate synthase hisHF","uniprot_id":"P33734","uniprot_name":"HIS5_YEAST","enzyme":true,"transporter":false,"gene_name":"HIS7","num_residues":552,"molecular_weight":"61067.60156","theoretical_pi":"5.15","general_function":"Involved in catalytic activity","specific_function":"IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutamine amidotransferase domain provides the ammonia necessary to the cyclase domain to produce IGP and AICAR from PRFAR","reactions":[{"id":1653,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2255,"direction":"\u003e","locations":null,"altext":"5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":4161,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006457","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1OX6","cellular_location":null,"genbank_gene_id":"X69815","genbank_protein_id":"395155","gene_card_id":"HIS7","chromosome_location":"chromosome 2","locus":"YBR248C","synonyms":["IGP synthase","IGPS","ImGP synthase","Glutamine amidotransferase","Cyclase"],"enzyme_classes":["2.4.2.-","4.1.3.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" imidazoleglycerol-phosphate synthase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" histidine family amino acid metabolic process"},{"category":"Process","description":" histidine metabolic process"},{"category":"Process","description":" histidine biosynthetic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"His_biosynth","identifier":"PF00977"}],"pathways":[{"name":"Histidine Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGCCGGTCGTTCACGTGATTGACGTTGAAAGTGGTAACCTACAGTCACTAACCAATGCAATTGAGCATTTAGGTTACGAAGTACAACTGGTGAAATCACCAAAGGATTTTAACATATCAGGCACGTCAAGATTGATTTTGCCTGGTGTCGGAAATTATGCCCATTTCGTCGACAATTTATTTAATAGAGGATTCGAAAAGCCGATAAGAGAATACATTGAATCTGGAAAACCAATAATGGGAATTTGCGTCGGGCTACAAGCGCTCTTTGCCGGTTCCGTGGAAAGCCCTAAGAGTACGGGTCTGAACTACATTGATTTTAAGTTGTCCAGGTTCGATGATTCAGAAAAGCCAGTACCAGAAATAGGTTGGAATTCTTGCATTCCCTCGGAAAACCTATTCTTTGGATTGGATCCATACAAGAGGTACTATTTCGTCCATTCTTTTGCTGCCATTCTGAATTCAGAAAAGAAAAAAAACCTAGAAAATGACGGTTGGAAAATTGCAAAAGCTAAGTACGGTTCAGAGGAATTTATTGCGGCAGTCAACAAGAATAATATATTCGCTACTCAGTTCCATCCTGAAAAATCAGGTAAAGCTGGTTTGAACGTCATTGAGAATTTTTTGAAGCAACAAAGTCCTCCGATTCCAAACTATAGTGCGGAAGAGAAGGAACTCTTAATGAATGACTATTCAAATTATGGTCTAACACGCAGAATTATTGCTTGTCTTGATGTACGTACTAATGACCAAGGTGATTTGGTGGTTACTAAAGGTGATCAATACGATGTACGTGAAAAAAGTGATGGTAAAGGTGTTAGAAACCTTGGTAAGCCTGTTCAGTTGGCACAGAAATATTACCAACAGGGTGCGGATGAAGTAACATTTTTGAATATAACTTCTTTTAGAGATTGTCCTTTGAAGGATACTCCGATGCTAGAGGTTCTGAAACAAGCCGCAAAGACAGTCTTTGTTCCATTGACAGTCGGTGGGGGGATCAAGGATATTGTCGATGTTGATGGAACCAAAATACCTGCTTTAGAAGTTGCAAGTCTATACTTCAGATCTGGTGCTGATAAAGTATCGATCGGTACGGATGCAGTCTATGCAGCCGAAAAATACTACGAGTTGGGTAACAGAGGAGATGGAACGTCACCAATAGAGACAATCTCGAAAGCATACGGTGCTCAGGCAGTTGTTATTTCTGTCGACCCTAAGAGAGTATATGTAAATTCACAAGCAGATACGAAGAACAAAGTCTTCGAGACAGAATATCCGGGCCCCAATGGAGAGAAATACTGCTGGTACCAATGTACAATCAAAGGTGGAAGAGAATCTAGAGACCTTGGTGTGTGGGAATTAACAAGGGCATGTGAAGCTCTAGGTGCTGGGGAGATTTTATTGAACTGCATAGACAAGGATGGCTCTAATTCTGGTTATGATCTGGAATTGATAGAACATGTTAAAGATGCGGTCAAGATTCCCGTCATTGCATCCAGTGGCGCCGGTGTACCCGAACATTTCGAAGAGGCCTTCCTAAAGACCCGCGCAGATGCTTGCTTGGGTGCAGGTATGTTCCACAGAGGTGAATTCACTGTTAACGATGTAAAGGAGTATTTACTAGAGCACGGATTAAAGGTTAGAATGGATGAAGAGTAA","protein_sequence":"MPVVHVIDVESGNLQSLTNAIEHLGYEVQLVKSPKDFNISGTSRLILPGVGNYGHFVDNLFNRGFEKPIREYIESGKPIMGICVGLQALFAGSVESPKSTGLNYIDFKLSRFDDSEKPVPEIGWNSCIPSENLFFGLDPYKRYYFVHSFAAILNSEKKKNLENDGWKIAKAKYGSEEFIAAVNKNNIFATQFHPEKSGKAGLNVIENFLKQQSPPIPNYSAEEKELLMNDYSNYGLTRRIIACLDVRTNDQGDLVVTKGDQYDVREKSDGKGVRNLGKPVQLAQKYYQQGADEVTFLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTKIPALEVASLYFRSGADKVSIGTDAVYAAEKYYELGNRGDGTSPIETISKAYGAQAVVISVDPKRVYVNSQADTKNKVFETEYPGPNGEKYCWYQCTIKGGRESRDLGVWELTRACEALGAGEILLNCIDKDGSNSGYDLELIEHVKDAVKIPVIASSGAGVPEHFEEAFLKTRADACLGAGMFHRGEFTVNDVKEYLLEHGLKVRMDEE"},{"created_at":"2011-05-24T19:28:29.000Z","updated_at":"2011-07-22T17:54:22.000Z","name":"Protein URA1","uniprot_id":"P07259","uniprot_name":"PYR1_YEAST","enzyme":true,"transporter":false,"gene_name":"URA2","num_residues":2214,"molecular_weight":"245124.0","theoretical_pi":"5.64","general_function":"Involved in carboxyl- or carbamoyltransferase activity","specific_function":"This protein is a \"fusion\" protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase)","reactions":[{"id":1332,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1365,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2254,"direction":"\u003e","locations":"Cytoplasm","altext":"2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2256,"direction":"\u003e","locations":null,"altext":"Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.","export":false,"pw_reaction_id":null,"source":null},{"id":3739,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006264","source":"Smpdb"},{"id":14248,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006692","source":"Smpdb"},{"id":14248,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006692","source":"Smpdb"},{"id":14249,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006733","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M27174","genbank_protein_id":"173146","gene_card_id":"URA2","chromosome_location":"chromosome 10","locus":"YJL130C","synonyms":["Glutamine-dependent carbamoyl-phosphate synthase","Aspartate carbamoyltransferase"],"enzyme_classes":["6.3.5.5","2.1.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" carbamoyl-phosphate synthase activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" aspartate carbamoyltransferase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carboxylic acid binding"},{"category":"Function","description":" amino acid binding"},{"category":"Function","description":" carboxyl- or carbamoyltransferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" nucleobase metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" pyrimidine base metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" pyrimidine base biosynthetic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" 'de novo' pyrimidine base biosynthetic process"},{"category":"Process","description":" glutamine metabolic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"CPSase_sm_chain","identifier":"PF00988"},{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"CPSase_L_D3","identifier":"PF02787"},{"name":"MGS","identifier":"PF02142"},{"name":"OTCace","identifier":"PF00185"},{"name":"OTCace_N","identifier":"PF02729"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGGCCACTATTGCTCCCACTGCTCCAATCACCCCTCCAATGGAATCTACGGGTGACCGTCTGGTTACGTTGGAACTTAAGGACGGCACGGTCTTACAAGGTTATTCATTTGGTGCTGAGAAATCCGTCGCTGGTGAATTAGTTTTCCAAACTGGTATGGTTGGTTATCCTGAATCTGTGACCGATCCATCTTATGAAGGCCAGATCTTAGTCATCACTTACCCATTGGTAGGCAATTATGGTGTCCCAGATATGCACTTGAGAGATGAATTGGTCGAAGAATTGCCAAGATATTTTGAAAGTAATAGAATCCATATTGCCGGTTTAGTTATTTCTCACTATACCGACGAGTACTCTCATTATCTTGCTAAATCTTCCTTAGGTAAATGGTTACAAAATGAAGGGATCCCAGCTGTTTATGGTGTTGATACAAGATCATTGACCAAGCATTTGAGAGATGCAGGTTCAATGTTGGGTAGGTTGTCTTTGGAAAAAAGCGGCTCTGACAGAACCATCTCCAGATCTTCCTCTTGGAGAAGTGCGTTTGATGTTCCTGAATGGGTGGATCCAAATGTTCAAAACCTAGTTTCTAAGGTCTCCATCAATGAACCTAAATTGTACGTTCCTCCAGCAGACAATAAGCACATCGAATTGCAAACCGGACCCGATGGTAAAGTTTTAAGGATTCTAGCCATTGACGTGGGTATGAAATACAATCAAATTCGTTGTTTTATCAAAAGGGGTGTAGAATTGAAAGTTGTTCCATGGAACTACGATTTCACTAAAGAAGATTATGATGGTCTGTTTATTTCAAATGGTCCAGGTGATCCATCTGTTCTAGATGATCTATCTCAAAGATTGTCAAATGTCCTGGAGGCTAAAAAGACGCCAGTATTCGGTATTTGTCTCGGTCATCAATTGATAGCAAGAGCTGCCGGTGCATCCACCCTAAAACTAAAATTTGGTAACCGTGGTCATAACATACCTTGTACATCAACTATAAGTGGTCGTTGTTACATAACATCTCAAAACCATGGGTTCGCTGTGGATGTTGACACTCTAACTTCCGGATGGAAGCCATTGTTTGTTAACGCGAATGATGACTCTAACGAAGGTATCTATCATTCTGAATTACCTTATTTTTCCGTCCAATTCCATCCAGAATCCACACCTGGCCCAAGAGATACAGAATTCTTGTTTGACGTTTTTATCCAAGCAGTTAAAGAATTCAAGTATACACAAGTGTTGAAACCAATCGCTTTCCCAGGTGGCCTATTAGAGGATAACGTTAAGGCACACCCTAGAATCGAAGCGAAGAAGGTTCTAGTTCTCGGTTCTGGTGGTTTGTCCATCGGTCAAGCTGGTGAATTTGACTACTCTGGTTCTCAAGCCATCAAAGCTTTGAAAGAAGAAGGTATCTATACAATTTTAATTAATCCAAACATTGCTACCATCCAAACTTCGAAAGGGTTGGCTGATAAGGTTTATTTTGTTCCTGTTACTGCAGAGTTCGTGAGAAAAGTTATTTTACATGAAAGGCCGGACGCCATTTATGTGACATTTGGTGGACAAACTGCTTTATCTGTTGGTATAGCCATGAAAGATGAATTTGAGGCGTTAGGAGTTAAAGTATTGGGTACTCCAATCGATACTATTATTACCACGGAAGACCGTGAACTCTTCAGTAATGCCATTGACGAAATTAATGAAAAATGTGCGAAATCTCAAGCTGCTAATTCAGTGGACGAGGCATTGGCCGCTGTCAAGGAGATCGGTTTCCCAGTTATTGTACGTGCTGCATATGCATTGGGAGGTTTAGGTTCCGGTTTCGCTAATAATGAAAAAGAATTGGTTGATCTATGTAATGTTGCATTTTCATCCTCACCTCAAGTTTTAGTCGAGAAATCTATGAAAGGTTGGAAAGAAGTCGAATATGAAGTTGTTCGTGATGCTTTTGACAACTGTATTACTGTTTGTAATATGGAAAATTTTGATCCACTAGGTATTCACACCGGTGATTCCATCGTTGTAGCCCCATCTCAAACTTTATCTGATGAAGATTACAATATGTTAAGAACTACTGCTGTTAATGTTATTAGACACTTAGGTGTTGTTGGTGAATGTAATATCCAATATGCTTTAAATCCCGTTTCTAAGGATTATTGCATCATTGAAGTTAATGCGCGTTTGTCACGTTCCTCTGCTTTAGCTTCTAAGGCTACTGGTTACCCATTGGCCTACACTGCGGCTAAGTTAGGTTTGAATATCCCATTAAATGAAGTTAAGAATTCCGTCACAAAATCCACATGTGCTTGTTTTGAACCTTCTCTAGACTACTGTGTTGTCAAAATGCCAAGATGGGATTTGAAGAAGTTCACCAGAGTTTCTACCGAATTATCTTCATCAATGAAATCTGTTGGTGAAGTTATGAGCATCGGTAGAACCTTCGAAGAAGCTATTCAAAAAGCTATCAGATCCACAGAATATGCTAACCTCGGATTCAATGAGACAGATCTAGATATCGACATTGATTACGAGTTGAACAACCCTACGGATATGCGTGTCTTCGCCATTGCAAATGCTTTTGCTAAGAAGGGATATTCTGTTGATAAAGTCTGGGAAATGACTAGAATTGATAAGTGGTTTTTAAACAAACTGCACGATTTGGTCCAATTTGCTGAGAAAATTAGTTCATTTGGTACTAAAGAGGAATTACCTTCCTTAGTTTTAAGACAGGCTAAGCAGTTAGGTTTTGATGACAGACAGATTGCAAGATTTTTGGATTCCAACGAAGTTGCCATCCGTAGATTAAGAAAAGAATATGGAATTACACCATTTGTCAAACAAATTGATACAGTTGCCGCTGAATTCCCCGCTTACACGAACTATTTATACATGACATACAATGCTGACTCACACGATTTATCCTTTGATGACCACGGTGTTATGGTCTTGGGTTCTGGTGTTTACCGTATCGGTTCTTCTGTCGAATTTGATTGGTGTGCTGTTACTGCAGTTAGAACATTACGTGCCAACAATATCAAAACTATCATGGTCAACTATAATCCAGAAACTGTTTCCACAGATTATGATGAGGCTGATAGACTATACTTTGAAACCATCAACCTTGAAAGAGTTTTGGATATTTACGAGATTGAAAACTCAAGCGGTGTTGTCGTATCAATGGGTGGTCAAACTTCCAACAACATCGCCATGACTTTACATCGTGAAAATGTAAAGATTCTTGGTACATCCCCTGACATGATTGATTCTGCTGAAAACCGTTACAAGTTCTCTCGTATGTTGGATCAAATTGGTGTTGACCAACCAGCTTGGAAAGAATTGACATCCATGGACGAAGCTGAATCTTTTGCCGAAAAGGTGGGTTATCCAGTTTTGGTACGTCCATCTTATGTGTTATCCGGTGCCGCCATGAATACTGTTTATTCTAAAAACGATTTGGAATCCTACTTAAACCAAGCCGTCGAAGTTTCACGTGATTATCCTGTTGTTATCACTAAATATATTGAAAACGCAAAGGAGATTGAAATGGATGCAGTTGCAAGAAATGGTGAATTGGTTATGCATGTTGTCTCTGAGCATGTTGAAAATGCAGGTGTCCACTCGGGTGATGCAACATTAATCGTTCCACCTCAAGATTTGGCTCCTGAAACTGTGGATAGAATTGTTGTCGCCACTGCTAAAATTGGTAAGGCTTTGAAAATTACAGGTCCATACAACATCCAATTCATTGCAAAGGACAATGAAATCAAGGTCATAGAATGTAATGTTCGTGCTTCGAGATCTTTCCCATTCATTTCAAAGGTTGTTGGCGTCAATCTGATTGAATTGGCAACAAAGGCCATAATGGGTTTGCCTTTGACGCCTTATCCTGTTGAAAAATTACCAGATGATTATGTCGCCGTTAAAGTACCACAATTCTCTTTCCCACGTTTAGCAGGAGCTGATCCAGTCTTAGGTGTTGAAATGGCCTCTACTGGTGAAGTCGCTACTTTTGGCCACTCGAAGTATGAAGCATACTTAAAGTCTTTGTTGGCAACCGGCTTCAAACTTCCAAAGAAGAATATTTTATTGTCTATTGGTTCTTACAAGGAAAAACAAGAATTGCTTTCTTCCGTACAAAAACTATACAACATGGGATATAAATTATTTGCAACATCAGGTACTGCTGACTTTTTATCTGAACATGGTATTGCCGTCCAATATCTGGAGGTTTTAAACAAGGATGATGATGATCAAAAATCAGAATACTCACTTACTCAACATTTGGCTAATAATGAAATTGACCTTTACATCAACTTGCCTTCTGCCAACAGGTTCCGTCGTCCTGCATCCTATGTTTCAAAGGGGTATAAAACACGTCGTTTGGCTGTCGATTATTCGGTTCCGTTGGTTACTAACGTTAAATGTGCAAAATTGTTGATTGAAGCCATTTCAAGAAATATCACTTTAGATGTTTCTGAACGTGATGCACAAACTTCCCACAGAACTATTACCTTACCTGGTTTAATCAATATCGCAACTTATGTTCCGAATGCATCCCATGTTATCAAAGGCCCAGCTGAACTGAAGGAGACCACACGTCTATTTTTGGAATCCGGTTTTACATACTGTCAATTGATGCCCAGATCCATCAGCGGACCTGTTATTACTGACGTTGCATCCTTGAAGGCCGCAAACTCTGTTTCCCAAGATTCATCTTACACTGACTTTTCTTTCACTATTGCTGGTACAGCACACAATGCTCATAGTGTTACGCAATCTGCTAGCAAAGTGACAGCATTGTTTTTGCCCCTACGTGAATTAAAGAACAAGATCACAGCAGTAGCTGAACTTCTGAATCAGTGGCCAACTGAAAAGCAAGTGATTGCAGAAGCTAAAACTGCAGATTTGGCATCGGTTTTATTGTTAACCTCCCTTCAAAACAGATCTATTCACATTACTGGTGTTTCGAATAAGGAAGATTTAGCTTTGATCATGACGGTCAAGGCAAAAGACCCTAGAGTGACTTGTGATGTCAATATTTATTCTTTGTTTATTGCCCAAGATGACTATCCGGAGGCAGTTTTCTTGCCTACTAAGGAAGATCAAGAGTTTTTCTGGAACAACCTTGATAGTATCGATGCTTTCTCTGTCGGTGCTCTTCCTGTCGCCTTGGCAAATGTCACAGGTAACAAGGTTGATGTTGGTATGGGTATCAAAGATTCATTACCACTATTGTTGGCTGCTGTTGAAGAAGGTAAATTAACCATTGATGATATCGTCCTTCGTCTGCATGACAATCCCGCTAAAATTTTCAACATCCCTACTCAGGACTCAGTTGTCGAAATTGATTTGGATTATTCTTTCAGACGTAATAAGAGATGGTCACCATTCAACAAAGATATGAACGGTGGTATTGAGCGTGTTGTCTATAATGGCGAAACATTAGTTTTGAGCGGTGAATTAGTTTCACCAGGCGCCAAAGGAAAATGCATTGTTAATCCAAGTCCAGCTTCCATAACTGCTTCCGCAGAGCTCCAATCTACTAGTGCTAAAAGAAGGTTCTCGATCACGGAAGAAGCAATCGCTGATAATTTAGATGCCGCGGAGGATGCAATTCCAGAACAGCCTTTGGAACAAAAATTGATGTCTTCAAGGCCACCAAGAGAACTTGTTGCTCCAGGCGCCATCCAGAATTTGATCCGTAGTAACAATCCATTCCGCGGAAGACATATATTGTCTATCAAACAATTCAAACGTTCTGATTTCCATGTGTTGTTTGCTGTTGCACAAGAACTAAGGGCACGTGTCGCAAGAGAAGGTGTCTTAGATTTAATGAAAGGCCACGTTATTACTACAATTTTCTTTGAACCATCTACTCGTACTTGTTCTTCATTCATTGCTGCTATGGAACGTTTGGGTGGTAGAATTGTAAATGTTAATCCATTGGTGTCTTCTGTCAAGAAAGGTGAAACCCTTCAAGATACTATCAGAACTTTGGCTTGTTACAGTGATGCCATTGTCATGCGTCATTCAGAAGAAATGTCTGTTCATATCGCCGCTAAATATTCTCCTGTTCCAATTATTAATGGTGGTAATGGTTCTCGCGAGCATCCTACGCAGGCCTTCTTGGATTTGTTTACGATTCGTGAAGAAATCGGTACTGTTAATGGTATTACTGTTACTTTCATGGGTGATCTCAAACATGGTAGAACCGTACATTCATTGTGTCGTTTGTTAATGCACTATCAAGTCAGAATTAATCTTGTTTCTCCTCCGGAATTGAGGTTACCAGAAGGATTAAGAGAAGAGCTAAGAAAAGCTGGCTTACTTGGTGTTGAGAGCATTGAATTAACCCCTCATATCATCTCAAAGACCGATGTTCTGTATTGTACAAGGGTCCAAGAAGAAAGATTCAATAGCCCTGAAGAATATGCACGTCTGAAGGATACTTATATCGTGGACAACAAGATCTTGGCACACGCCAAAGAAAATATGGCTATCATGCATCCATTGCCTCGTGTAAATGAAATCAAAGAGGAAGTGGACTACGATCATCGTGCTGCTTACTTCAGACAAATGAAGTATGGTTTGTTCGTCAGAATGGCTTTGTTGGCCATGGTCATGGGTGTTGATATGTGA","protein_sequence":"MATIAPTAPITPPMESTGDRLVTLELKDGTVLQGYSFGAEKSVAGELVFQTGMVGYPESVTDPSYEGQILVITYPLVGNYGVPDMHLRDELVEELPRYFESNRIHIAGLVISHYTDEYSHYLRKSSLGKWLQNEGIPAVYGVDTRSLTKHLRDAGSMLGRLSLEKSGSDRTISRSSSWRSAFDVPEWVDPNVQNLVSKVSINEPKLYVPPADNKHIELQTGPDGKVLRILAIDVGMKYNQIRCFIKRGVELKVVPWNYDFTKEDYDGLFISNGPGDPSVLDDLSQRLSNVLEAKKTPVFGICLGHQLIARAAGASTLKLKFGNRGHNIPCTSTISGRCYITSQNHGFAVDVDTLTSGWKPLFVNANDDSNEGIYHSELPYFSVQFHPESTPGPRDTEFLFDVFIQAVKEFKYTQVLKPIAFPGGLLEDNVKAHPRIEAKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYFVPVTAEFVRKVILHERPDAIYVTFGGQTALSVGIAMKDEFEALGVKVLGTPIDTIITTEDRELFSNAIDEINEKCAKSQAANSVDEALAAVKEIGFPVIVRAAYALGGLGSGFANNEKELVDLCNVAFSSSPQVLVEKSMKGWKEVEYEVVRDAFDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPVSKDYCIIEVNARLSRSSALASKATGYPLAYTAAKLGLNIPLNEVKNSVTKSTCACFEPSLDYCVVKMPRWDLKKFTRVSTELSSSMKSVGEVMSIGRTFEEAIQKAIRSTEYANLGFNETDLDIDIDYELNNPTDMRVFAIANAFAKKGYSVDKVWEMTRIDKWFLNKLHDLVQFAEKISSFGTKEELPSLVLRQAKQLGFDDRQIARFLDSNEVAIRRLRKEYGITPFVKQIDTVAAEFPAYTNYLYMTYNADSHDLSFDDHGVMVLGSGVYRIGSSVEFDWCAVTAVRTLRANNIKTIMVNYNPETVSTDYDEADRLYFETINLERVLDIYEIENSSGVVVSMGGQTSNNIAMTLHRENVKILGTSPDMIDSAENRYKFSRMLDQIGVDQPAWKELTSMDEAESFAEKVGYPVLVRPSYVLSGAAMNTVYSKNDLESYLNQAVEVSRDYPVVITKYIENAKEIEMDAVARNGELVMHVVSEHVENAGVHSGDATLIVPPQDLAPETVDRIVVATAKIGKALKITGPYNIQFIAKDNEIKVIECNVRASRSFPFISKVVGVNLIELATKAIMGLPLTPYPVEKLPDDYVAVKVPQFSFPRLAGADPVLGVEMASTGEVATFGHSKYEAYLKSLLATGFKLPKKNILLSIGSYKEKQELLSSVQKLYNMGYKLFATSGTADFLSEHGIAVQYLEVLNKDDDDQKSEYSLTQHLANNEIDLYINLPSANRFRRPASYVSKGYKTRRLAVDYSVPLVTNVKCAKLLIEAISRNITLDVSERDAQTSHRTITLPGLINIATYVPNASHVIKGPAELKETTRLFLESGFTYCQLMPRSISGPVITDVASLKAANSVSQDSSYTDFSFTIAGTAHNAHSVTQSASKVTALFLPLRELKNKITAVAELLNQWPTEKQVIAEAKTADLASVLLLTSLQNRSIHITGVSNKEDLALIMTVKAKDPRVTCDVNIYSLFIAQDDYPEAVFLPTKEDQEFFWNNLDSIDAFSVGALPVALANVTGNKVDVGMGIKDSLPLLLAAVEEGKLTIDDIVLRLHDNPAKIFNIPTQDSVVEIDLDYSFRRNKRWSPFNKDMNGGIERVVYNGETLVLSGELVSPGAKGKCIVNPSPASITASAELQSTSAKRRFSITEEAIADNLDAAEDAIPEQPLEQKLMSSRPPRELVAPGAIQNLIRSNNPFRGRHILSIKQFKRSDFHVLFAVAQELRAAVAREGVLDLMKGHVITTIFFEPSTRTCSSFIAAMERLGGRIVNVNPLVSSVKKGETLQDTIRTLACYSDAIVMRHSEEMSVHIAAKYSPVPIINGGNGSREHPTQAFLDLFTIREEIGTVNGITVTFMGDLKHGRTVHSLCRLLMHYQVRINLVSPPELRLPEGLREELRKAGLLGVESIELTPHIISKTDVLYCTRVQEERFNSPEEYARLKDTYIVDNKILAHAKENMAIMHPLPRVNEIKEEVDYDHRAAYFRQMKYGLFVRMALLAMVMGVDM"},{"created_at":"2011-05-24T19:29:59.000Z","updated_at":"2011-07-22T17:54:11.000Z","name":"Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial","uniprot_id":"Q03557","uniprot_name":"GATH_YEAST","enzyme":true,"transporter":false,"gene_name":"HER2","num_residues":464,"molecular_weight":"50918.0","theoretical_pi":"8.84","general_function":"Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor","specific_function":"Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln). Required for HMG2-induced ER-remodeling","reactions":[{"id":1319,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2257,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"X80836","genbank_protein_id":"530350","gene_card_id":"HER2","chromosome_location":"chromosome 13","locus":"YMR293C","synonyms":["Glu-ADT subunit A","HMG2-induced ER-remodeling protein 2","Loss of respiratory capacity protein 6"],"enzyme_classes":["6.3.5.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"}],"pfams":[{"name":"Amidase","identifier":"PF01425"}],"pathways":[],"gene_sequence":"ATGCCACTGAAACGCTCCTTAAAAGAATCAATCGAAAGATTATCTAGTTTTCAATCAAAATATAATATTTTCACTAGTATCAATCCATCTCCTTATTCAATCACAAATAAAAAAGGTACAAAAGAAACATTGACAGGTTGCGTTGCCAGTATCAAGGATAATATAGTTACAAAAGATTTTCCAACCACATGTGCCTCACATATACTTGAGAATTTCAAGTCTCCCTTCGATGCAACAGTAGTGAAACTATTAAAACAGGCAGGAGTGCATATCTTAGGCAAGACAAATTTAGATGAATTTGGAATGGGTTCTGGGGGAGTACATTCAATAAGAGGGCCCGTAATTAACCCTTTATATCCTCATGAGGACAAGAAGATCATGGGAGGTTCATCGTCTGGAGCCGCTGCAAGCGTTGCTTGCGATCTAGTCGATTTTGCCTTGGGAACAGATACTGGTGGCTCCGTTAGGCTCCCCGCATGCTATGGATCTGTTTTAGGATTCAAGCCGTCCTATGGACGGTTGTCAAGATTTGGCGTAATAGCGTATTCTCAATCTTTAGACACTGTTGGCATACTTAGCAAAAAGATAAACGTCTTGCGAAAAGTATTTCATACGCTCGATAAATATGACATGAAAGATCCCACTTCCTTAAGTGTGGAATTGCGTGAATTGATAGAAGGGAATAAAAAGGTTAGGAGACCTTTAAAGGTAGGAATTGTAAAGGAATTTAGCCATGAAAGTATGCCCATTGGGTTCCACAGATTATATTTATCCTTACTAGAAAAGCTGATAAATTTAGGGCTTGAAATATACCCTGTATCCATTCCATCTGTAAAAAACTGTTTACCGATTTATTATACGCTATCACCCGCTGAAGCGGCTTCCAATTTATCAAGGTATGATGGTATCAGATATGGATACAGAGATTCAGAACTCGATATAAAAGACGGTATTTTATTCGCACCTACTAGGTCCAAATTCGGAACAGAAGTTAAGAATAGAATCATTCTAGGTAATTATAATCTTTGTTCAGATGCATTTAAGAACAATTTTATTAAGGCAGAAAAGCTACGAGTTAATTTGATCGATGAATTTGACGGGATCTTCAGATTTCCAAATGTTTTAACTAATTCTAAGGGAAATCCAGACGGCCTAGATCTACTGATAGTTCCCACATCGTCCAAGCTTCCTGGATCCATAAGGGACTTCGAAGAAGAGGAAGCCAAATCTCCGGCTAACTCGTATATAAACGATGTCTTTACTGTCCCAATGTCATTGGCTGGACTACCAAGTTTATCAATGCCTTTAAAAGAGAAGACCCCGATTGGCTTACAGGTAGTAGGTCAATATGGTGATGATTCCACTGTGTTAGATTTTGTCGAGTCAATATCATAA","protein_sequence":"MPLKRSLKESIERLSSFQSKYNIFTSINPSPYSITNKKGTKETLTGCVASIKDNIVTKDFPTTCASHILENFKSPFDATVVKLLKQAGVHILGKTNLDEFGMGSGGVHSIRGPVINPLYPHEDKKIMGGSSSGAAASVACDLVDFALGTDTGGSVRLPACYGSVLGFKPSYGRLSRFGVIAYSQSLDTVGILSKKINVLRKVFHTLDKYDMKDPTSLSVELRELIEGNKKVRRPLKVGIVKEFSHESMPIGFHRLYLSLLEKLINLGLEIYPVSIPSVKNCLPIYYTLSPAEAASNLSRYDGIRYGYRDSELDIKDGILFAPTRSKFGTEVKNRIILGNYNLCSDAFKNNFIKAEKLRVNLIDEFDGIFRFPNVLTNSKGNPDGLDLLIVPTSSKLPGSIRDFEEEEAKSPANSYINDVFTVPMSLAGLPSLSMPLKEKTPIGLQVVGQYGDDSTVLDFVESIS"},{"created_at":"2011-05-24T19:30:54.000Z","updated_at":"2011-05-29T05:06:11.000Z","name":"Carbamoyl-phosphate synthase arginine-specific large chain","uniprot_id":"P03965","uniprot_name":"CARB_YEAST","enzyme":true,"transporter":false,"gene_name":"CPA2","num_residues":1118,"molecular_weight":"123914.0","theoretical_pi":"4.95","general_function":"Involved in ATP binding","specific_function":"2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate","reactions":[{"id":2254,"direction":"\u003e","locations":"Cytoplasm","altext":"2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"K01178","genbank_protein_id":"171310","gene_card_id":"CPA2","chromosome_location":"chromosome 10","locus":"YJR109C","synonyms":["Arginine-specific carbamoyl-phosphate synthetase, ammonia chain"],"enzyme_classes":["6.3.5.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" carbamoyl-phosphate synthase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"CPSase_L_D3","identifier":"PF02787"},{"name":"MGS","identifier":"PF02142"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGACATCGATTTATACATCAACAGAGCCTACGAATTCTGCTTTTACTACCGAGGACTACAAACCTCAATTAGTTGAAGGAGTAAATTCTGTACTTGTCATTGGATCAGGAGGGCTCTCTATTGGTCAAGCTGGTGAATTCGATTACAGTGGTTCTCAAGCTATCAAAGCTCTGAAGGAAGATAACAAGTTTACTATATTGGTTAACCCAAATATCGCTACTAACCAGACTTCTCATTCCCTGGCGGACAAGATTTATTACTTGCCCGTTACACCAGAATACATCACATATATCATTGAACTTGAAAGGCCGGATGCTATACTTTTAACCTTCGGTGGTCAAACAGGTCTAAATTGTGGGGTGGCTCTGGATGAATCTGGTGTTTTGGCTAAATACAACGTCAAAGTTTTAGGTACTCCTATCAAAACTTTGATCACTTCTGAAGATAGGGATCTTTTCGCATCTGCGTTAAAGGATATCAACATTCCCATCGCAGAATCATTTGCTTGTGAAACCGTGGATGAAGCTTTGGAGGCTGCTGAAAGGGTCAAATACCCAGTTATTGTCAGATCTGCATACGCTTTGGGTGGGTTAGGCTCAGGTTTCGCTAACAATGCAAGTGAAATGAAGGAACTTGCCGCACAGTCCTTGTCGTTGGCCCCACAAATTCTTGTTGAAAAATCTTTGAAAGGTTGGAAAGAAGTTGAATATGAAGTGGTCAGAGATAGGGTTGGTAACTGTATTACAGTATGTAATATGGAAAATTTCGACCCACTTGGTGTTCATACTGGTGATTCTATGGTTTTTGCTCCTTCGCAGACCCTATCAGATGAAGAGTTTCATATGTTAAGATCCGCCGCAATTAAAATCATTAGACACCTTGGTGTTATTGGTGAATGTAATGTCCAATACGCTTTGCAACCTGATGGGCTAGACTATAGAGTTATTGAAGTGAACGCACGTTTATCTCGTTCCTCTGCATTGGCGTCTAAGGCCACTGGTTATCCCTTAGCATACACTGCCGCCAAAATTGGGCTAGGCTATACTTTGCCAGAATTGCCAAACCCAATCACAAAAACTACAGTGGCTAACTTTGAGCCATCTTTGGATTATATTGTGGCAAAAATACCTAAGTGGGATCTTTCTAAGTTCCAATACGTGGACAGATCCATTGGTTCCTCTATGAAATCAGTTGGAGAAGTTATGGCTATTGGTAGAAACTATGAAGAAGCCTTTCAAAAAGCATTAAGACAGGTGGATCCATCATTATTGGGATTCCAAGGTTCTACTGAATTCGGCGATCAACTTGATGAAGCCTTGAGAACTCCAACTGATAGAAGAGTCCTTGCCATTGGTCAGGCCTTAATCCATGAAAACTATACTGTTGAGAGAGTTAATGAATTGAGTAAAATTGATAAATGGTTTCTTTACAAGTGCATGAACATTGTTAATATCTATAAAGAGCTTGAATCAGTTAAATCTTTAAGTGACTTGAGTAAAGATCTCTTGCAGAGAGCCAAGAAATTAGGGTTTTCAGATAAGCAGATTGCGGTTACTATAAATAAACACGCCTCCACAAACATTAACGAACTGGAAATCAGAAGTTTAAGAAAAACGTTAGGTATAATCCCTTTTGTCAAGAGAATCGATACTTTGGCCGCAGAATTTCCAGCACAAACCAATTATTTGTATACCACTTACAATGCTACAAAGAACGATGTGGAGTTCAACGAAAATGGTATGCTGGTTTTAGGCTCTGGTGTCTATCGTATTGGTTCATCTGTAGAATTTGATTGGTGTGCCGTGAACACCGCGAAGACATTAAGAGATCAAGGCAAGAAAACTATCATGATAAATTATAACCCAGAAACAGTTTCCACAGATTTCGATGAAGTTGATAGATTATACTTTGAAGAATTATCGTATGAAAGAGTGATGGACATTTATGAGTTGGAGCAATCTGAGGGTTGCATTATTTCTGTCGGTGGTCAATTACCTCAAAACATTGCCTTGAAACTTTACGATAACGGCTGTAATATAATGGGTACCAATCCAAACGATATTGATAGAGCTGAGAACAGACACAAATTCTCATCTATTTTGGATTCTATTGATGTTGACCAACCTGAATGGAGTGAATTAACATCAGTAGAAGAAGCAAAATTATTTGCTTCTAAAGTTAACTACCCTGTGTTGATTCGTCCCTCATATGTTCTTTCCGGTGCGGCAATGAGTGTTGTTAATAATGAGGAGGAACTGAAGGCTAAATTAACTTTGGCATCTGACGTTTCTCCAGACCATCCAGTCGTCATGTCTAAATTTATTGAAGGTGCTCAAGAAATTGATGTGGACGCCGTTGCTTATAATGGTAATGTCTTGGTACATGCCATTTCCGAGCATGTTGAAAATGCGGGTGTGCACTCCGGTGATGCTTCTTTAGTCTTACCGCCACAACATCTTTCTGACGATGTGAAGATTGCCCTAAAAGACATTGCTGATAAGGTCGCAAAAGCTTGGAAGATCACTGGCCCCTTCAATATGCAAATCATCAAGGATGGGGAGCATACATTGAAAGTGATTGAATGTAACATTAGAGCTTCTAGATCATTTCCATTCGTTTCAAAAGTTTTAGGCGTTAATTTTATTGAAATTGCTGTCAAGGCATTTTTGGGCGGTGACATTGTACCAAAACCTGTTGATTTGATGCTCAACAAAAAGTACGACTATGTTGCTACTAAAGTTCCTCAATTTTCCTTTACAAGGTTGGCTGGTGCAGATCCTTTCTTAGGGGTTGAAATGGCATCAACTGGTGAAGTTGCTTCATTTGGTAGAGATTTAATTGAAAGCTATTGGACTGCTATTCAAAGTACCATGAACTTCCATGTACCACTACCTCCAAGTGGTATATTATTTGGAGGTGATACATCTCGAGAATACTTGGGCCAAGTGGCTTCCATAGTGGCCACTATTGGTTACAGAATATACACAACTAATGAGACCACTAAAACGTATCTACAGGAACACATCAAAGAAAAGAACGCAAAGGTTTCTTTGATTAAATTTCCAAAGAATGATAAGAGAAAATTGCGTGAACTATTTCAAGAATATGACATAAAAGCTGTTTTCAATTTAGCCTCCAAGAGAGCTGAGAGCACTGACGATGTTGACTATATTATGAGAAGGAATGCTATTGATTTTGCTATCCCATTGTTCAATGAACCTCAAACGGCTTTGTTATTTGCAAAGTGTTTGAAGGCAAAAATTGCAGAAAAGATCAAAATTTTGGAATCTCATGACGTTATAGTTCCACCAGAAGTCCGTTCCTGGGATGAATTTATTGGTTTCAAAGCATATTGA","protein_sequence":"MTSIYTSTEPTNSAFTTEDYKPQLVEGVNSVLVIGSGGLSIGQAGEFDYSGSQAIKALKEDNKFTILVNPNIATNQTSHSLADKIYYLPVTPEYITYIIELERPDAILLTFGGQTGLNCGVALDESGVLAKYNVKVLGTPIKTLITSEDRDLFASALKDINIPIAESFACETVDEALEAAERVKYPVIVRSAYALGGLGSGFANNASEMKELAAQSLSLAPQILVEKSLKGWKEVEYEVVRDRVGNCITVCNMENFDPLGVHTGDSMVFAPSQTLSDEEFHMLRSAAIKIIRHLGVIGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATGYPLAYTAAKIGLGYTLPELPNPITKTTVANFEPSLDYIVAKIPKWDLSKFQYVDRSIGSSMKSVGEVMAIGRNYEEAFQKALRQVDPSLLGFQGSTEFGDQLDEALRTPTDRRVLAIGQALIHENYTVERVNELSKIDKWFLYKCMNIVNIYKELESVKSLSDLSKDLLQRAKKLGFSDKQIAVTINKHASTNINELEIRSLRKTLGIIPFVKRIDTLAAEFPAQTNYLYTTYNATKNDVEFNENGMLVLGSGVYRIGSSVEFDWCAVNTAKTLRDQGKKTIMINYNPETVSTDFDEVDRLYFEELSYERVMDIYELEQSEGCIISVGGQLPQNIALKLYDNGCNIMGTNPNDIDRAENRHKFSSILDSIDVDQPEWSELTSVEEAKLFASKVNYPVLIRPSYVLSGAAMSVVNNEEELKAKLTLASDVSPDHPVVMSKFIEGAQEIDVDAVAYNGNVLVHAISEHVENAGVHSGDASLVLPPQHLSDDVKIALKDIADKVAKAWKITGPFNMQIIKDGEHTLKVIECNIRASRSFPFVSKVLGVNFIEIAVKAFLGGDIVPKPVDLMLNKKYDYVATKVPQFSFTRLAGADPFLGVEMASTGEVASFGRDLIESYWTAIQSTMNFHVPLPPSGILFGGDTSREYLGQVASIVATIGYRIYTTNETTKTYLQEHIKEKNAKVSLIKFPKNDKRKLRELFQEYDIKAVFNLASKRAESTDDVDYIMRRNAIDFAIPLFNEPQTALLFAKCLKAKIAEKIKILESHDVIVPPEVRSWDEFIGFKAY"},{"created_at":"2011-05-24T19:31:37.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"CTP synthase 1","uniprot_id":"P28274","uniprot_name":"URA7_YEAST","enzyme":true,"transporter":false,"gene_name":"URA7","num_residues":579,"molecular_weight":"64709.80078","theoretical_pi":"5.91","general_function":"Involved in CTP synthase activity","specific_function":"Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen","reactions":[{"id":1416,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1417,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2258,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + UTP + NH(3) = ADP + phosphate + CTP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X53995","genbank_protein_id":"440583","gene_card_id":"URA7","chromosome_location":"chromosome 2","locus":"YBL039C","synonyms":["CTP synthetase 1","UTP--ammonia ligase 1"],"enzyme_classes":["6.3.4.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" CTP synthase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"CTP_synth_N","identifier":"PF06418"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGAAGTACGTTGTTGTTTCAGGTGGTGTCATTTCGGGTATCGGTAAAGGTGTTCTTGCATCTTCAACTGGTATGCTAATGAAAACCCTCGGTTTAAAGGTTACGTCAATTAAAATTGACCCTTATATGAACATTGATGCAGGTACTATGTCTCCTTTGGAACATGGTGAATGTTTCGTGCTTGACGACGGTGGTGAAACAGATTTGGACTTGGGTAACTACGAGAGATACCTTGGAGTTACTTTGACTAAAGATCATAACATTACTACTGGTAAAATATACTCGCACGTTATTGCTAAGGAAAGAAAAGGTGACTATTTAGGCAAAACCGTGCAAATTGTCCCTCATTTGACCAACGCTATCCAAGATTGGATTGAGCGCGTGGCCAAAATTCCTGTAGATGACACCGGTATGGAACCAGATGTTTGTATCATTGAATTGGGTGGGACAGTTGGTGACATTGAAAGTGCTCCTTTTGTGGAGGCACTAAGACAATTCCAATTTAAAGTTGGAAAGGAAAATTTTGCCTTGATACACGTTTCTCTAGTTCCTGTCATCCACGGTGAACAAAAAACTAAGCCAACTCAAGCTGCCATCAAAGGTTTGAGGTCTCTTGGTTTAGTTCCAGATATGATCGCCTGTAGATGTAGTGAAACTTTGGATAAACCAACAATCGATAAGATTGCCATGTTTTGTCATGTGGGGCCTGAACAGGTGGTTAACGTTCACGATGTTAATTCTACTTATCACGTCCCATTGTTGCTACTGGAACAAAAGATGATTGATTACTTACACGCCAGATTAAAGTTAGATGAAATATCACTTACAGAAGAAGAAAAACAAAGAGGCCTGGAATTATTGTCTAAATGGAAGGCCACAACAGGTAACTTCGATGAATCCATGGAAACAGTGAAGATTCGTTTGGTTGGGAAATACACCAACTTGAAAGATTCTTATCTATCAGTGATAAAAGCATTGGAACATTCATCCATGAAGTGTCGTCGTAAGTTAGACATTAAATGGGTGGAAGCTACTGATTTGGAACCTGAAGCACAAGAAAGCAACAAAACTAAATTTCATGAAGCATGGAACATGGTCAGTACCGCAGACGGTATCTTAATCCCCGGTGGTTTTGGTGTTAGAGGTACTGAAGGTATGGTTTTGGCTGCTAGATGGGCTCGTGAAAATCACATTCCATTCTTAGGGGTTTGCCTGGGTTTACAAATTGCCACCATTGAATTTACACGTAGTTCGTTGGGAAGAAAAGACAGTCATTCGGCAGAATTTTATCCAGACATTGATGAAAAAAATCACGTTGTCGTTTTCATGCCTGAAATTGACAAGGAAACCATGGGGGGCTCAATGAGATTAGGTTTGAGACCAACATTTTTCCAAAATGAAACTGAATGGAGTCAAATCAAGAAGTTATACGGTGACGTCTCCGAAGTCCATGAAAGACACCGTCACCGTTACGAAATCAATCCAAAGATGGTTGATGAATTGGAAAACAACGGGTTGATCTTTGTAGGTAAGGACGACACTGGAAAGCGTTGTGAGATTTTGGAATTAAAGAATCACCCATACTATATTGCTACTCAATATCACCCAGAATACACATCAAAGGTCTTAGATCCATCCAAACCATTTTTGGGTTTAGTTGCTGCTTCCGCTGGTATCCTTCAAGATGTCATTGAAGGTAAGTACGATCTTGAGGCCGGCGAAAACAAATTCAACTTTTAA","protein_sequence":"MKYVVVSGGVISGIGKGVLASSTGMLMKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLDDGGETDLDLGNYERYLGVTLTKDHNITTGKIYSHVIAKERKGDYLGKTVQIVPHLTNAIQDWIERVAKIPVDDTGMEPDVCIIELGGTVGDIESAPFVEALRQFQFKVGKENFALIHVSLVPVIHGEQKTKPTQAAIKGLRSLGLVPDMIACRCSETLDKPTIDKIAMFCHVGPEQVVNVHDVNSTYHVPLLLLEQKMIDYLHARLKLDEISLTEEEKQRGLELLSKWKATTGNFDESMETVKIALVGKYTNLKDSYLSVIKALEHSSMKCRRKLDIKWVEATDLEPEAQESNKTKFHEAWNMVSTADGILIPGGFGVRGTEGMVLAARWARENHIPFLGVCLGLQIATIEFTRSVLGRKDSHSAEFYPDIDEKNHVVVFMPEIDKETMGGSMRLGLRPTFFQNETEWSQIKKLYGDVSEVHERHRHRYEINPKMVDELENNGLIFVGKDDTGKRCEILELKNHPYYIATQYHPEYTSKVLDPSKPFLGLVAASAGILQDVIEGKYDLEAGENKFNF"},{"created_at":"2011-05-24T19:32:21.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Glutamine synthetase","uniprot_id":"P32288","uniprot_name":"GLNA_YEAST","enzyme":true,"transporter":false,"gene_name":"GLN1","num_residues":370,"molecular_weight":"41705.60156","theoretical_pi":"6.29","general_function":"Involved in glutamate-ammonia ligase activity","specific_function":"ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine","reactions":[{"id":1579,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2259,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.","export":false,"pw_reaction_id":null,"source":null},{"id":14887,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007078","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z68111","genbank_protein_id":"1072403","gene_card_id":"GLN1","chromosome_location":"chromosome 16","locus":"YPR035W","synonyms":["GS","Glutamate--ammonia ligase"],"enzyme_classes":["6.3.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" acid-ammonia (or amide) ligase activity"},{"category":"Function","description":" ammonia ligase activity"},{"category":"Function","description":" glutamate-ammonia ligase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" glutamine biosynthetic process"}],"pfams":[{"name":"Gln-synt_C","identifier":"PF00120"},{"name":"Gln-synt_N","identifier":"PF03951"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"}],"gene_sequence":"ATGGCTGAAGCAAGCATCGAAAAGACTCAAATTTTACAAAAATATCTAGAACTGGACCAAAGAGGTAGAATAATTGCCGAATACGTTTGGATCGATGGTACTGGTAACTTACGTTCCAAAGGTAGAACTTTGAAGAAGAGAATCACATCCATTGACCAATTGCCAGAATGGAACTTCGACGGTTCTTCTACCAACCAAGCGCCAGGCCACGACTCTGACATCTATTTGAAACCCGTTGCTTACTACCCAGATCCCTTCAGGAGAGGTGACAACATTGTTGTCTTGGCCGCATGTTACAACAATGACGGTACTCCAAACAAGTTCAACCACAGACACGAAGCTGCCAAGCTATTTGCTGCTCATAAGGATGAAGAAATCTGGTTTGGTCTAGAACAAGAATACACTCTATTTGACATGTATGACGATGTTTACGGATGGCCAAAGGGTGGGTACCCAGCTCCACAAGGTCCTTACTACTGTGGTGTTGGTGCCGGTAAGGTTTATGCCAGAGACATGATCGAAGCTCACTACAGAGCTTGTTTGTATGCCGGATTAGAAATTTCTGGTATTAACGCTGAAGTCATGCCATCTCAATGGGAATTCCAAGTCGGTCCATGTACCGGTATTGACATGGGTGACCAATTATGGATGGCCAGATACTTTTTGCACAGAGTGGCAGAAGAGTTTGGTATCAAGATCTCATTCCATCCAAAGCCATTGAAGGGTGACTGGAACGGTGCCGGTTGTCACGCTAACGTTTCCACCAAGGAAATGAGACAACCAGGTGGTACGAAATACATCGAACAAGCCATCGAGAAGTTATCCAAGAGACACGCTGAACACATTAAGTTGTACGGTAGCGATAACGACATGAGATTAACTGGTAGACATGAAACCGCTTCCATGACTGCCTTTTCTTCTGGTGTCGCCAACAGAGGTAGCTCAATTAGAATCCCAAGATCCGTCGCCAAGGAAGGTTACGGTTACTTTGAAGACCGTAGACCAGCTTCCAACATCGACCCATACTTGGTTACAGGTATCATGTGTGAAACTGTTTGCGGTGCTATTGACAATGCTGACATGACGAAGGAATTTGAAAGAGAATCTTCATAA","protein_sequence":"MAEASIEKTQILQKYLELDQRGRIIAEYVWIDGTGNLRSKGRTLKKRITSIDQLPEWNFDGSSTNQAPGHDSDIYLKPVAYYPDPFRRGDNIVVLAACYNNDGTPNKFNHRHEAAKLFAAHKDEEIWFGLEQEYTLFDMYDDVYGWPKGGYPAPQGPYYCGVGAGKVYARDMIEAHYRACLYAGLEISGINAEVMPSQWEFQVGPCTGIDMGDQLWMARYFLHRVAEEFGIKISFHPKPLKGDWNGAGCHANVSTKEMRQPGGTKYIEQAIEKLSKRHAEHIKLYGSDNDMRLTGRHETASMTAFSSGVANRGSSIRIPRSVAKEGYGYFEDRRPASNIDPYLVTGIMCETVCGAIDNADMTKEFERESS"},{"created_at":"2011-05-24T19:33:54.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial","uniprot_id":"P33893","uniprot_name":"GATB_YEAST","enzyme":true,"transporter":false,"gene_name":"PET112","num_residues":541,"molecular_weight":"61842.19922","theoretical_pi":"7.8","general_function":"Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor","specific_function":"Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln)","reactions":[{"id":2257,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"L22072","genbank_protein_id":"347493","gene_card_id":"PET112","chromosome_location":"chromosome 2","locus":"YBL080C","synonyms":["Glu-ADT subunit B","Cytochrome oxidase assembly factor PET112"],"enzyme_classes":["6.3.5.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"}],"pfams":[{"name":"GatB_N","identifier":"PF02934"},{"name":"GatB_Yqey","identifier":"PF02637"}],"pathways":[],"gene_sequence":"ATGTTGCGGCTTGCACGTTTTTATTCTTTGGCCAGAACCAAAGCCATACATAGTCACGGTGCACCCTTCAGGCCGGAATATGCATTGAAGTGTGGATTGGAGATTCATACGCAATTGAACACCAAAAACAAGCTTTTTTCACAATCAACGAATAGCGCCACATCTCTAGTGGATGCACCAAACCATCATACTAGTTATTATGACATAGCTCTACCGGGAACGCAGCCGGTTTTGAATCTGGAAGCAATCTTGTTTGCCATGAAACTATCCTTGGCACTGGGTTCTCAAGTGAATAGCATATCTCAGTTTGATAGGAAGCATTATTTTTATGGAGATCAACCTCAAGGCTATCAACTGACGCAGCACTACAGGCCGTTTGCTCGGGGTGGGAAGATCAATCTGTCGAAGGAATTGGATGATATCGATGAATCAGCCAAGGAAATCGGTATCTTACAGTTGCAGATAGAGCAGGACACGGGGAAGTCACACTATACAGAGACAGATAAAGACGTTATTACTTTGGTTGATTTAAATAGGTCGAACGTCCCGCTTATCGAATTGGTAACTAAACCAGATTTCAGTGATATTAAACAGGTTAGAGCGTTTATTAAAAAATATCAGAATTTGGTACGTCATTTGCACATTTCCTCTGGGGACCTGGAAACGGGCGCCATGCGAGTGGACGTTAACCTCTCAATTAATGAATATGCACGCGTTGAGTTGAAGAATTTACCCAATACTAGTTCCATCATCAATGCAATCAAGTACGAATATCAGCGGCAAGTTGAGTTGATTTCTGTGGGTGACACTAGCTCACTGATGGAGCCAGAAACAAGGGGCTGGACAGGCTCATCAACGGTGAAGTTGAGAAGCAAAGAAACCACGATCGATTACAGGTACATGCCTGATCCAGAATTGCCGTATATCAACCTCGCACCAGACGTTATCAGTGGTGTGAGAGGGTTGATGCCCCAATTACCGGACGATATAATGAGAATTCTTATGAAGAAACCCTATCAATTATCATTGAAGGACGCCAAGATTCTGACTTATAATAGTAACCAAAACGATATGTACAATCATGAGGCGTTGAGATCGTACTACTTAGACACCTTCCGTGAATTTTCCAAGCTTGCTGGTGAACGTAGTAACGCGAAATTACCTACGAATTGGATAATCCATGAATTCTTGGGAGATTTGAACAAGCTACAAATTCCATTGGCCAAAGCAAAAGAAATTTTGCCTCCTCCGGTTTTCGCCCAGTTTTTGAAGTTATTGCATGAAGAGGTTATATCCGCAACTAGTGGTAAAATGTTACTGTTTCACATATTGGAAAATTTCGAGCAGAGTAACTGCCAAGATTTGTCTATTCCAGATTTTTCAAAACTAATCGAGAAATTTGAATTGCATGCGATTAATCAGGTCGACCCTCAAGAATTGATGGATCTCTGTAATGATGTCATTGCACAGCACACAGATGACACTTTTATACGGAACCTGGTTACTGGTAAAAAGAAGTCCTCTTTAAAATTCCTAATTGGACAAGGAATGAGACGAAGCCAGGGACGTATAAAGGCAAACGAATTCGAGAAAAAATTCAAAGAGATCTTAAATATTCAATGGTAA","protein_sequence":"MLRLARFYSLARTKAIHSHGAPFRPEYALKCGLEIHTQLNTKNKLFSQSTNSATSLVDAPNHHTSYYDIALPGTQPVLNLEAILFAMKLSLALGSQVNSISQFDRKHYFYGDQPQGYQLTQHYRPFARGGKINLSKELDDIDESAKEIGILQLQIEQDTGKSHYTETDKDVITLVDLNRSNVPLIELVTKPDFSDIKQVRAFIKKYQNLVRHLHISSGDLETGAMRVDVNLSINEYARVELKNLPNTSSIINAIKYEYQRQVELISVGDTSSLMEPETRGWTGSSTVKLRSKETTIDYRYMPDPELPYINLAPDVISGVRGLMPQLPDDIMRILMKKPYQLSLKDAKILTYNSNQNDMYNHEALRSYYLDTFREFSKLAGERSNAKLPTNWIIHEFLGDLNKLQIPLAKAKEILAPPVFAQFLKLLHEEVISATSGKMLLFHILENFEQSNCQDLSIPDFSKLIEKFELHAINQVDPQELMDLCNDVIAQHTDDTFIRNLVTGKKKSSLKFLIGQGMRRSQGRIKANEFEKKFKEILNIQW"},{"created_at":"2011-05-24T19:34:32.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Anthranilate synthase component 1","uniprot_id":"P00899","uniprot_name":"TRPE_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP2","num_residues":507,"molecular_weight":"56767.0","theoretical_pi":"5.65","general_function":"Involved in biosynthetic process","specific_function":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate","reactions":[{"id":2251,"direction":"\u003e","locations":"","altext":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":14103,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006527","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U18839","genbank_protein_id":"603328","gene_card_id":"TRP2","chromosome_location":"chromosome 5","locus":"YER090W","synonyms":["Anthranilate synthase component I"],"enzyme_classes":["4.1.3.27"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" anthranilate synthase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" tryptophan biosynthetic process"}],"pfams":[{"name":"Anth_synt_I_N","identifier":"PF04715"},{"name":"Chorismate_bind","identifier":"PF00425"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACCGCTTCCATCAAAATTCAACCGGATATTGACTCTCTAAAGCAATTACAGCAGCAAAATGACGATAGTTCCATAAATATGTATCCCGTGTATGCGTATTTGCCATCATTGGATCTGACTCCTCACGTGGCATATCTAAAATTGGCACAATTGAACAACCCTGATAGAAAGGAATCATTTCTGTTGGAAAGTGCTAAGACAAATAATGAATTAGATCGTTATTCATTCATAGGTATCTCGCCACGCAAGACCATCAAAACCGGTCCTACTGAAGGCATTGAAACAGATCCTTTGGAAATTTTGGAAAAGGAGATGTCTACCTTTAAAGTAGCCGAAAATGTTCCTGGTTTACCGAAATTAAGTGGTGGTGCTATTGGTTATATTTCTTATGACTGTGTTCGTTATTTCGAGCCAAAAACAAGAAGGCCTTTGAAAGATGTCCTAAGACTTCCAGAGGCATATTTAATGCTTTGTGATACCATTATTGCCTTTGATAATGTTTTTCAGAGATTTCAAATCATTCATAACATTAATACCAATGAAACTTCGTTGGAGGAAGGTTACCAAGCTGCAGCACAAATAATCACTGATATCGTATCAAAGCTAACCGACGATTCCTCGCCAATACCATATCCAGAACAACCTCCTATTAAATTGAATCAAACTTTTGAATCGAATGTGGGCAAGGAAGGTTACGAAAATCACGTCTCCACTTTGAAGAAGCATATTAAGAAAGGTGATATTATTCAAGGTGTGCCATCGCAAAGAGTGGCAAGGCCAACTTCGTTACATCCTTTCAATATTTACAGACATTTACGTACAGTGAACCCATCTCCTTACCTGTTTTATATTGATTGTTTGGATTTCCAAATCATTGGTGCATCTCCAGAATTGTTGTGCAAATCGGATTCCAAAAATAGAGTCATTACCCATCCAATTGCTGGTACTGTCAAACGTGGGGCTACTACTGAAGAGGATGATGCTTTAGCGGACCAATTACGTGGCTCGTTAAAAGACCGTGCAGAACATGTTATGCTGGTAGATTTAGCAAGAAACGATATTAACAGAATTTGTGACCCATTAACAACAAGTGTCGATAAACTGTTAACTATTCAAAAATTTTCTCATGTCCAACATCTGGTTTCTCAAGTCAGCGGTGTTCTCCGCCCAGAAAAGACAAGATTTGATGCATTCAGATCGATTTTCCCTGCAGGTACTGTCAGTGGTGCTCCAAAGGTTAGAGCCATGGAATTGATTGCCGAACTAGAAGGAGAAAGGCGTGGGGTTTATGCAGGCGCCGTAGGTCATTGGTCATACGACGGTAAAACAATGGACAATTGTATCGCTTTAAGGACTATGGTCTATAAAGATGGCATTGCTTACTTGCAAGCTGGCGGTGGTATTGTTTACGATTCAGATGAGTACGATGAATATGTCGAAACCATGAATAAAATGATGGCCAATCACAGTACTATTGTGCAAGCAGAAGAATTGTGGGCCGATATCGTAGGATCAGCTTAA","protein_sequence":"MTASIKIQPDIDSLKQLQQQNDDSSINMYPVYAYLPSLDLTPHVAYLKLAQLNNPDRKESFLLESAKTNNELDRYSFIGISPRKTIKTGPTEGIETDPLEILEKEMSTFKVAENVPGLPKLSGGAIGYISYDCVRYFEPKTRRPLKDVLRLPEAYLMLCDTIIAFDNVFQRFQIIHNINTNETSLEEGYQAAAQIITDIVSKLTDDSSPIPYPEQPPIKLNQTFESNVGKEGYENHVSTLKKHIKKGDIIQGVPSQRVARPTSLHPFNIYRHLRTVNPSPYLFYIDCLDFQIIGASPELLCKSDSKNRVITHPIAGTVKRGATTEEDDALADQLRGSLKDRAEHVMLVDLARNDINRICDPLTTSVDKLLTIQKFSHVQHLVSQVSGVLRPEKTRFDAFRSIFPAGTVSGAPKVRAMELIAELEGERRGVYAGAVGHWSYDGKTMDNCIALRTMVYKDGIAYLQAGGGIVYDSDEYDEYVETMNKMMANHSTIVQAEELWADIVGSA"},{"created_at":"2011-05-24T19:35:15.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"GMP synthase [glutamine-hydrolyzing]","uniprot_id":"P38625","uniprot_name":"GUAA_YEAST","enzyme":true,"transporter":false,"gene_name":"GUA1","num_residues":525,"molecular_weight":"58481.80078","theoretical_pi":"6.47","general_function":"Involved in catalytic activity","specific_function":"ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate","reactions":[{"id":1608,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2260,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X70397","genbank_protein_id":"460064","gene_card_id":"GUA1","chromosome_location":"chromosome 13","locus":"YMR217W","synonyms":["GMP synthetase","Glutamine amidotransferase"],"enzyme_classes":["6.3.5.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" GMP synthase (glutamine-hydrolyzing) activity"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" GMP biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"GMP_synt_C","identifier":"PF00958"},{"name":"NAD_synthase","identifier":"PF02540"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGGCTGCCGGTGAACAAGTTTCTAACATGTTTGACACTATCTTAGTGTTAGACTTTGGTTCTCAATACTCTCATTTGATTACCAGAAGATTAAGAGAGTTTAACATCTATGCTGAGATGTTGCCATGCACTCAGAAGATCTCTGAGTTGGGCTGGACTCCAAAGGGTGTCATTCTTTCTGGTGGTCCATATTCCGTATACGCTGAAGACGCTCCACACGTAGACCATGCTATCTTTGATTTGAACGTTCCAATCCTGGGTATCTGTTACGGTATGCAAGAATTGGCTTGGATTAATGGTAAACAAGTTGGTCGTGGTGACAAGAGAGAGTACGGTCCTGCCACTTTGAAGGTGATTGACGATTCCAACTCTCTATTCAAAGGTATGAACGACTCTACTGTCTGGATGTCTCACGGTGATAAATTGCACGGCTTGCCAACTGGTTACAAGACCATTGCCACCTCCGATAACTCCCCATACTGTGGTATTGTCCACGAAACTAAGCCAATCTATGGTATCCAATTCCACCCAGAAGTTACACATTCTACCCAAGGTAAGACTCTTTTGAAAAACTTCGCCGTTGATTTGTGTCACGCTAAGCAAAACTGGACTATGGAAAACTTTATCGACACTGAAATAAACAGAATCAGAAAACTGGTCGGTCCAACTGCTGAAGTCATTGGTGCTGTTTCCGGTGGTGTTGATTCTACTGTTGCATCCAAATTGATGACAGAAGCCATCGGTGATAGATTCCATGCCATTTTGGTCGATAACGGTGTTTTAAGATTAAATGAAGCTGCTAACGTTAAAAAGACTCTTGTCGAAGGTTTAGGTATCAACTTGATGGTTGTCGATGCTTCCGAAGAATTTTTAAGCAAATTGAAGGGTGTCACTGACCCAGAAAAGAAGAGAAAGATTATTGGTAACACATTTATCCACGTCTTTGAAAGAGAAGCTGAAAAAATTAAGCCAAGAGATGGTAAGGAGATTCAATTCCTGTTACAAGGTACTCTTTATCCAGATGTCATCGAATCCATTTCTTTCAAAGGTCCTTCTCAAACCATTAAAACTCATCACAACGTCGGTGGTTTACTAGAGAACATGAAATTAAAGCTAATTGAACCATTGAGAGAACTGTTCAAAGACGAAGTCAGGCATCTAGGTGAATTATTAGGAATCCCTCATGATCTAGTCTGGAGACACCCTTTCCCTGGTCCAGGTATTGCTATTCGTGTTCTAGGTGAAGTTACTAAGGAACAAGTCGAAATAGCAAGAAAAGCTGACAACATTTACATTGAAGAAATCAAGAAGGCCGGCTTATACAACCAAATTTCCCAAGCCTTTGCCTGTTTGTTGCCCGTTAAATCCGTTGGTGTTATGGGTGACCAAAGAACCTATGATCAAGTTATTGCTTTGAGGGCCATTGAAACTACTGATTTCATGACTGCTGACTGGTTCCCATTCGAACACAGTTTCTTGAAGAAAGTCGCCTCAAGAATTGTCAATGAAGTCGATGGGGTTGCTAGGGTCACTTACGATATAACTTCCAAACCTCCTGCAACTGTTGAATGGGAATGA","protein_sequence":"MAAGEQVSNMFDTILVLDFGSQYSHLITRRLREFNIYAEMLPCTQKISELGWTPKGVILSGGPYSVYAEDAPHVDHAIFDLNVPILGICYGMQELAWINGKQVGRGDKREYGPATLKVIDDSNSLFKGMNDSTVWMSHGDKLHGLPTGYKTIATSDNSPYCGIVHETKPIYGIQFHPEVTHSTQGKTLLKNFAVDLCHAKQNWTMENFIDTEINRIRKLVGPTAEVIGAVSGGVDSTVASKLMTEAIGDRFHAILVDNGVLRLNEAANVKKTLVEGLGINLMVVDASEEFLSKLKGVTDPEKKRKIIGNTFIHVFEREAEKIKPKDGKEIQFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFKDEVRHLGELLGIPHDLVWRHPFPGPGIAIRVLGEVTKEQVEIARKADNIYIEEIKKAGLYNQISQAFACLLPVKSVGVMGDQRTYDQVIALRAIETTDFMTADWFPFEHSFLKKVASRIVNEVDGVARVTYDITSKPPATVEWE"},{"created_at":"2011-05-24T19:35:50.000Z","updated_at":"2011-07-22T17:54:12.000Z","name":"Asparagine synthetase [glutamine-hydrolyzing] 1","uniprot_id":"P49089","uniprot_name":"ASNS1_YEAST","enzyme":true,"transporter":false,"gene_name":"ASN1","num_residues":572,"molecular_weight":"64469.60156","theoretical_pi":"6.02","general_function":"Involved in asparagine synthase (glutamine-hydrolyzing) activity","specific_function":"ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate","reactions":[{"id":1330,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2261,"direction":"\u003e","locations":"","altext":"ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3711,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006184","source":"Smpdb"},{"id":3712,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006185","source":"Smpdb"},{"id":3731,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006256","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U40829","genbank_protein_id":"1066479","gene_card_id":"ASN1","chromosome_location":"chromosome 16","locus":"YPR145W","synonyms":["Glutamine-dependent asparagine synthetase 1"],"enzyme_classes":["6.3.5.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" asparagine synthase (glutamine-hydrolyzing) activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" asparagine metabolic process"},{"category":"Process","description":" asparagine biosynthetic process"}],"pfams":[{"name":"Asn_synthase","identifier":"PF00733"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Asparagine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTGTGGTATTTTCGCCGCTTTCAGGCACGAAGACGTGCATAGATATAAGCCAAAGGCTCTACAACTATCAAAAAGAATCAGACACCGTGGTCCAGATTGGTCCGGTAATGCTATCAAGAACTCCACTATATTTGTTCATGAAAGACTAGCCATTGTCGGTGTGGAATCCGGTGCTCAACCAATTACTTCTTCAGACGGAGAGTACATGCTATGTGTTAACGGTGAAATCTACAACCACATTCAATTAAGAGAAGAATGCGCAGACTACGAGTTTGGAACACTGAGTGACTGTGAGCCTATCATCCCAATGTACTTAAAGCACGATATCGACGCTCCTAAGTACTTGGATGGTATGTTTGCTTGGACTCTTTACGACGCTAAACAAGATCGTATTGTGGCAGCCAGAGACCCAATCGGTATTACGACATTATATATGGGACGCTCTTCCGCTTCTCCAAAGACCGTTTATTTTGCATCCGAACTAAAATGTTTGACTGACGACTGTGACACTATCACTGCATTCCCACCGGGCCACGTATACGATTCTAAGACTGACAAGATCACCCGTTACTTCACACCAGATTGGCTGGACGAAAAACGCATTCCTTCCACCCCAATAGATTACATGGCAATTAGACACTCCTTAGAAAAAGCCGTTAGAAAGAGATTAATGGCCGAAGTCCCATACGGTGTTCTATTGTCGGGTGGTTTGGACTCCTCTTTAATCGCTTCCATTGCTGCCCGTGAAACTGCAAAGGCCACTAACGATGTCGAACCATCAACTTACGATAGTAAGGCAAGACATCTAGCAGGTATCGACGATGACGGTAAGCTACACACTGCTGGTTGGACAAGTCTCCATTCCTTTGCCATCGGTTTACCAAATGCTCCAGATTTGCAAGCCGCAAGAAAGGTTGCCAAATTCATCGGCTCTATTCATCATGAACACACCTTTACATTACAAGAAGGTTTGGATGCTTTGGACGACGTGATCTACCATTTGGAAACTTACGACGTTACCACTATCAGAGCTTCCACTCCAATGTTCTTACTATCCAGAAAGATTAAGGCCCAAGGGGTCAAGATGGTTCTTTCCGGTGAAGGTTCCGATGAAATCTTCGGTGGTTATCTATATTTCGCACAAGCTCCTTCTGCGGCAGAATTTCACACTGAATCCGTGCAACGTGTCAAGAACTTGCATTTGGCAGATTGTTTGAGAGCTAACAAGTCTACGATGGCTTGGGGTCTAGAAGCTCGTGTTCCATTCTTAGACAGAGAATTTTTGCAATTGTGTATGAACATCGATCCAAATGAAAAGATGATTAAACCAAAGGAAGGACGTATTGAAAAGTACATTCTAAGGAAGGCATTCGACACCACAGGAGAACCAGATGCTAAGCCATATTTACCAGAAGAAATTTTATGGAGACAAAAAGAACAATTTTCCGACGGTGTTGGTTACTCCTGGATCGACGGATTAAAAGATACCGCCGAAGCAGTCATTTCAGATGAAATGTTTGCCAGTCCAAAGGCCGAATGGGGTAGTGACATTCCAACCACAAAAGAGGCTTTCTGGTACAGACTAAAATTCGATGCTTTGTTCCCTCAAAAGACCGTGGCTGACACCGTTATGAGATGGATTCCAAAGGCCGACTGGGGTTGTGCTGAAGATCCTTCTGGTAGATATGCCCAAATTCATGAAAAACATATCGAATAA","protein_sequence":"MCGIFAAFRHEDVHRYKPKALQLSKRIRHRGPDWSGNAIKNSTIFVHERLAIVGVESGAQPITSSDGEYMLCVNGEIYNHIQLREECADYEFGTLSDCEPIIPMYLKHDIDAPKYLDGMFAWTLYDAKQDRIVAARDPIGITTLYMGRSSASPKTVYFASELKCLTDDCDTITAFPPGHVYDSKTDKITRYFTPDWLDEKRIPSTPIDYMAIRHSLEKAVRKRLMAEVPYGVLLSGGLDSSLIASIAARETAKATNDVEPSTYDSKARHLAGIDDDGKLHTAGWTSLHSFAIGLPNAPDLQAARKVAKFIGSIHHEHTFTLQEGLDALDDVIYHLETYDVTTIRASTPMFLLSRKIKAQGVKMVLSGEGSDEIFGGYLYFAQAPSAAEFHTESVQRVKNLHLADCLRANKSTMAWGLEARVPFLDREFLQLCMNIDPNEKMIKPKEGRIEKYILRKAFDTTGEPDAKPYLPEEILWRQKEQFSDGVGYSWIDGLKDTAEAVISDEMFASPKAEWGSDIPTTKEAFWYRLKFDALFPQKTVADTVMRWIPKADWGCAEDPSGRYAQIHEKHIE"},{"created_at":"2011-05-24T19:36:59.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Glutamate synthase [NADH]","uniprot_id":"Q12680","uniprot_name":"GLT1_YEAST","enzyme":true,"transporter":false,"gene_name":"GLT1","num_residues":2145,"molecular_weight":"238100.0","theoretical_pi":"6.55","general_function":"Involved in catalytic activity","specific_function":"Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate","reactions":[{"id":1574,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2262,"direction":"\u003e","locations":null,"altext":"2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":3743,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006270","source":"Smpdb"},{"id":14888,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007079","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z67750","genbank_protein_id":"1061267","gene_card_id":"GLT1","chromosome_location":"chromosome 4","locus":"YDL171C","synonyms":["NADH-GOGAT"],"enzyme_classes":["1.4.1.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH2 group of donors"},{"category":"Function","description":" glutamate synthase activity"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" glutamate synthase activity, NADH or NADPH as acceptor"},{"category":"Function","description":" FMN binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" glutamate metabolic process"},{"category":"Process","description":" glutamate biosynthetic process"}],"pfams":[{"name":"GATase_2","identifier":"PF00310"},{"name":"Glu_syn_central","identifier":"PF04898"},{"name":"Glu_synthase","identifier":"PF01645"},{"name":"GXGXG","identifier":"PF01493"},{"name":"Pyr_redox","identifier":"PF00070"},{"name":"Pyr_redox_2","identifier":"PF07992"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCAGTGTTGAAATCAGACAATTTCGATCCATTGGAAGAAGCTTACGAAGGTGGGACAATTCAAAACTATAACGATGAACACCATCTTCATAAATCTTGGGCAAATGTGATTCCGGACAAACGAGGACTTTACGACCCTGATTATGAACATGACGCTTGTGGTGTCGGTTTCGTAGCAAATAAGCATGGTGAACAGTCTCACAAGATTGTTACTGACGCTAGATATCTTTTAGTGAATATGACACATCGTGGTGCCGTCTCATCTGATGGGAACGGTGACGGTGCCGGTATTCTGCTAGGTATTCCTCACGAATTTATGAAAAGAGAATTCAAGTTAGATCTTGATCTAGACATACCTGAGATGGGCAAATACGCCGTAGGTAACGTCTTCTTCAAGAAGAACGAAAAAAATAACAAGAAAAATTTAATTAAGTGTCAGAAGATTTTCGAGGATTTAGCTGCATCCTTCAACTTATCCGTATTAGGTTGGAGAAACGTCCCCGTAGATTCTACTATTTTAGGAGACGTTGCATTATCTCGTGAACCTACTATTCTACAGCCATTATTGGTTCCATTGTATGATGAAAAACAACCGGAGTTTAATGAAACTAAATTTAGAACTCAATTGTATCTTTTAAGGAAGGAGGCCTCTCTTCAAATAGGACTGGAAAACTGGTTCTATGTTTGTTCCCTAAACAATACCACCATTGTTTACAAGGGTCAATTGACGCCAGCTCAAGTGTATAACTACTATCCCGACTTGACTAATGCGCATTTCAAATCCCACATGGCGTTGGTCCATTCAAGATTTTCCACTAATACTTTCCCCTCTTGGGATAGAGCTCAACCTTTACGTTGGCTAGCTCATAATGGTGAAATTAACACCTTAAGAGGTAACAAGAATTGGATGCGCTCCAGAGAAGGTGTGATGAATTCAGCAACTTTCAAAGATGAGTTAGACAAACTATACCCAATTATCGAAGAAGGTGGTTCTGATTCAGCTGCATTGGATAACGTTTTAGAACTATTGACTATTAATGGCACATTATCTCTACCTGAAGCTGTTATGATGATGGTTCCTGAAGCGTATCATAAGGATATGGATTCTGACCTAAAAGCATGGTACGACTGGGCTGCATGTCTGATGGAACCTTGGGATGGTCCAGCTTTGTTAACTTTCACTGATGGACGTTACTGTGGTGCTATATTGGATAGAAATGGTTTAAGACCTTGTCGTTATTACATCACTAGTGATGACAGAGTTATCTGTGCTTCAGAGGTAGGTGTCATTCCTATCGAAAATTCATTGGTTGTTCAAAAAGGTAAACTGAAGCCAGGTGATTTATTCCTAGTGGATACTCAATTGGGTGAAATGGTCGATACTAAAAAGTTAAAATCTCAAATCTCAAAAAGACAAGATTTTAAGTCTTGGTTATCCAAAGTCATCAAGTTAGACGACTTGTTATCAAAAACCGCTAATTTGGTTCCTAAAGAATTTATATCACAGGATTCATTGTCTTTGAAAGTTCAAAGTGACCCACGTCTATTGGCCAATGGTTATACCTTCGAACAAGTCACATTTCTGTTAACTCCAATGGCTTTAACAGGTAAAGAAGCTTTAGGTTCGATGGGTAACGATGCGCCACTGGCTTGTTTAAATGAAAATCCTGTCTTACTTTATGATTATTTCAGACAATTGTTTGCTCAAGTGACCAATCCTCCAATTGACCCAATTCGTGAAGCAAATGTTATGTCGTTAGAATGTTATGTCGGACCTCAAGGCAACCTTTTGGAAATGCATTCATCTCAATGTGATCGTTTATTATTGAAATCTCCTATTTTGCATTGGAATGAGTTCCAAGCTTTGAAAAACATTGAAGCTGCTTACCCATCATGGTCTGTAGCAGAAATTGATATCACATTCGACAAGAGTGAGGGTCTATTGGGCTATACCGACACAATTGATAAAATCACTAAGTTAGCGAGCGAAGCAATTGATGATGGTAAAAAGATCTTAATAATTACTGACAGGAAAATGGGTGCCAACCGTGTTTCCATCTCCTCTTTGATTGCAATTTCATGTATTCATCATCACCTAATCAGAAACAAGCAGCGTTCCCAAGTTGCTTTGATTTTGGAAACAGGTGAAGCCAGAGAAATTCACCATTTCTGTGTCCTACTAGGTTATGGTTGTGATGGTGTTTATCCATACTTAGCCATGGAAACTTTGGTCAGAATGAATAGAGAAGGTCTACTTCGTAATGTCAACAATGACAATGATACACTTGAGGAAGGGCAAATACTAGAAAATTACAAGCACGCTATTGATGCAGGTATCTTGAAGGTTATGTCTAAAATGGGTATCTCCACTCTAGCATCCTACAAAGGTGCTCAAATTTTTGAAGCCCTAGGTTTAGATAACTCTATTGTTGATTTGTGTTTCACAGGTACTTCTTCCAGAATTAGAGGTGTAACTTTCGAGTATTTGGCTCAAGATGCCTTTTCTTTACATGAGCGTGGTTATCCATCCAGACAAACCATTAGTAAATCTGTTAACTTACCAGAAAGTGGTGAATACCACTTTAGGGATGGTGGTTACAAACACGTCAACGAACCAACCGCAATTGCTTCGTTACAAGATACTGTCAGAAACAAAAATGATGTCTCTTGGCAATTATATGTAAAGAAGGAAATGGAAGCAATTAGAGACTGTACACTAAGAGGACTGTTAGAATTAGATTTTGAAAATTCTGTCAGTATCCCTCTAGAACAAGTTGAACCATGGACTGAAATTGCCAGAAGATTTGCGTCAGGTGCAATGTCTTATGGTTCTATTTCTATGGAAGCTCACTCTACATTGGCTATTGCCATGAATCGTTTAGGGGCCAAATCCAATTGTGGTGAAGGTGGTGAAGACGCAGAACGTTCTGCTGTTCAAGAAAACGGTGATACTATGAGATCTGCTATCAAACAAGTTGCTTCCGCTAGATTCGGTGTAACTTCATACTACTTGTCAGATGCTGATGAAATCCAAATTAAGATTGCTCAGGGTGCTAAGCCGGGTGAAGGTGGTGAACTACCAGCCCACAAAGTGTCTAAGGATATCGCAAAAACCAGGCACTCCACCCCTAATGTTGGGTTAATCTCTCCTCCTCCTCATCACGATATTTATTCCATTGAAGATTTGAAACAACTGATTTATGATTTGAAATGTGCTAATCCAAGAGCGGGAATTTCTGTAAAGTTGGTTTCCGAAGTTGGTGTTGGTATTGTTGCCTCTGGTGTAGCTAAGGCTAAAGCCGATCATATCTTAGTTTCTGGTCATGATGGTGGTACAGGTGCTGCAAGATGGACGAGTGTCAAATATGCGGGTTTGCCATGGGAATTAGGTCTAGCTGAAACTCACCAGACTTTAGTCTTGAATGATTTAAGACGTAATGTTGTTGTCCAAACCGATGGTCAATTGAGAACTGGGTTTGATATTGCTGTTGCAGTTTTATTAGGGGCAGAATCTTTTACCTTGGCAACAGTTCCATTAATTGCTATGGGTTGTGTTATGTTAAGAAGATGTCACTTGAACTCTTGTGCTGTTGGTATTGCCACACAAGATCCATATTTGAGAAGTAAGTTTAAGGGTCAGCCCGAACATGTTATCAACTTCTTCTATTACTTGATCCAAGATTTAAGACAAATCATGGCCAAGTTAGGATTCCGTACCATTGACGAAATGGTGGGTCATTCTGAAAAATTAAAGAAAAGGGACGACGTAAATGCCAAAGCCATAAATATCGATTTATCTCCTATTTTGACCCCAGCACATGTTATTCGTCCAGGTGTTCCAACCAAGTTCACTAAGAAACAAGACCACAAACTCCACACCCGTCTAGATAATAAGTTAATCGATGAGGCTGAAGTTACTTTGGATCGTGGCTTACCAGTGAATATTGACGCCTCTATAATCAATACTGATCGTGCACTCGGTTCTACTTTATCTTACAGAGTCTCGAAGAAATTTGGTGAAGATGGTTTGCCAAAGGACACCGTTGTCGTTAACATAGAAGGTTCAGCGGGTCAATCTTTTGGTGCTTTCCTAGCTTCTGGTATCACTTTTATCTTGAATGGTGATGCTAATGATTATGTTGGTAAAGGTTTATCCGGTGGTATTATTGTCATTAAACCACCAAAGGATTCTAAATTCAAGAGTGATGAAAATGTAATTGTTGGTAACACTTGTTTCTATGGTGCTACTTCTGGTACTGCATTCATTTCAGGTAGTGCCGGTGAGCGTTTCGGTGTCAGAAACTCTGGTGCCACCATCGTTGTTGAGAGAATTAAGGGTAACAATGCCTTTGAGTATATGACTGGTGGTCGTGCCATTGTCTTATCACAAATGGAATCCCTAAACGCCTTCTCTGGTGCTACTGGTGGTATTGCATACTGTTTAACTTCCGATTACGACGATTTTGTTGGAAAGATTAACAAAGATACTGTTGAGTTAGAATCATTATGTGACCCGGTCGAGATTGCGTTTGTTAAGAATTTGATCCAGGAGCATTGGAACTACACACAATCTGATCTAGCAGCCAGGATTCTCGGTAATTTCAACCATTATTTGAAAGATTTCGTTAAAGTCATTCCAACTGATTATAAGAAAGTTTTGTTGAAGGAGAAAGCAGAAGCTGCCAAGGCAAAGGCTAAGGCAACTTCAGAATACTTAAAGAAGTTTAGATCGAACCAAGAAGTTGATGACGAAGTCAATACTCTATTGATTGCTAATCAAAAAGCTAAAGAGCAAGAAAAAAAGAAGAGTATTACTATTTCAAATAAGGCCACTTTGAAGGAGCCTAAGGTTGTTGATTTAGAAGATGCAGTTCCAGATTCCAAACAGCTAGAGAAGAATAGCGAAAGGATTGAAAAAACACGTGGTTTTATGATCCACAAACGTCGTCATGAGACACACAGAGATCCAAGAACCAGAGTTAATGACTGGAAAGAATTTACTAACCCTATTACCAAGAAGGATGCCAAATATCAAACTGCGAGATGTATGGATTGTGGTACACCATTCTGTTTATCTGATACCGGTTGTCCCCTATCTAACATTATCCCCAAGTTTAATGAATTGTTATTCAAGAACCAATGGAAGTTGGCACTGGACAAATTGCTAGAGACAAACAATTTCCCAGAATTCACTGGAAGAGTATGTCCAGCACCCTGTGAGGGAGCTTGTACACTAGGTATTATTGAAGACCCAGTCGGCATAAAATCGGTTGAAAGAATTATCATTGACAATGCTTTCAAGGAAGGATGGATTAAGCCTTGTCCACCAAGTACACGCACTGGCTTTACAGTGGGTGTCATTGGTTCTGGTCCAGCAGGTTTAGCGTGTGCTGATATGTTGAACCGTGCCGGACATACGGTCACTGTTTATGAAAGATCCGACCGTTGTGGTGGGTTATTGATGTATGGTATTCCAAACATGAAGTTGGATAAGGCTATAGTGCAACGTCGTATTGATCTATTGAGTGCCGAAGGTATTGACTTTGTTACCAACACCGAAATTGGTAAAACCATAAGCATGGATGAGCTAAAGAACAAGCACAATGCAGTAGTGTATGCTATCGGTTCTACCATTCCACGTGACTTACCTATTAAGGGTCGTGAATTGAAGAATATTGATTTTGCCATGCAGTTGTTGGAATCTAACACAAAAGCTTTATTGAACAAAGATCTGGAAATCATTCGTGAAAAGATCCAAGGTAAGAAAGTAATTGTTGTCGGTGGTGGTGACACAGGTAACGATTGTTTAGGTACATCTGTAAGACACGGTGCAGCATCAGTTTTGAATTTCGAATTGTTGCCTGAGCCACCAGTGGAACGTGCCAAAGACAATCCATGGCCTCAATGGCCGCGTGTCATGAGAGTGGACTACGGTCATGCTGAAGTGAAAGAGCATTATGGTAGAGACCCTCGTGAATACTGCATCTTGTCCAAGGAATTTATCGGTAACGATGAGGGTGAAGTCACTGCCATCAGAACTGTGCGCGTAGAATGGAAGAAGTCACAAAGTGGCGTATGGCAAATGGTAGAAATTCCCAACAGTGAAGAGATCTTTGAAGCCGATATCATTTTGTTGTCTATGGGTTTCGTGGGTCCTGAATTGATCAATGGCAACGATAACGAAGTTAAGAAGACAAGACGTGGTACGATTGCCACACTCGACGACTCCTCATACTCTATTGATGGAGGAAAGACTTTTGCATGTGGTGACTGTAGAAGAGGGCAATCTTTGATTGTCTGGGCCATCCAAGAAGGTAGAAAATGTGCTGCCTCTGTCGATAAGTTCCTAATGGACGGCACTACGTATCTACCAAGTAATGGTGGTATCGTTCAACGTGATTACAAACTATTGAAAGAATTAGCTAGTCAAGTCTAA","protein_sequence":"MPVLKSDNFDPLEEAYEGGTIQNYNDEHHLHKSWANVIPDKRGLYDPDYEHDACGVGFVANKHGEQSHKIVTDARYLLVNMTHRGAVSSDGNGDGAGILLGIPHEFMKREFKLDLDLDIPEMGKYAVGNVFFKKNEKNNKKNLIKCQKIFEDLAASFNLSVLGWRNVPVDSTILGDVALSREPTILQPLLVPLYDEKQPEFNETKFRTQLYLLRKEASLQIGLENWFYVCSLNNTTIVYKGQLTPAQVYNYYPDLTNAHFKSHMALVHSRFSTNTFPSWDRAQPLRWLAHNGEINTLRGNKNWMRSREGVMNSATFKDELDKLYPIIEEGGSDSAALDNVLELLTINGTLSLPEAVMMMVPEAYHKDMDSDLKAWYDWAACLMEPWDGPALLTFTDGRYCGAILDRNGLRPCRYYITSDDRVICASEVGVIPIENSLVVQKGKLKPGDLFLVDTQLGEMVDTKKLKSQISKRQDFKSWLSKVIKLDDLLSKTANLVPKEFISQDSLSLKVQSDPRLLANGYTFEQVTFLLTPMALTGKEALGSMGNDAPLACLNENPVLLYDYFRQLFAQVTNPPIDPIREANVMSLECYVGPQGNLLEMHSSQCDRLLLKSPILHWNEFQALKNIEAAYPSWSVAEIDITFDKSEGLLGYTDTIDKITKLASEAIDDGKKILIITDRKMGANRVSISSLIAISCIHHHLIRNKQRSQVALILETGEAREIHHFCVLLGYGCDGVYPYLAMETLVRMNREGLLRNVNNDNDTLEEGQILENYKHAIDAGILKVMSKMGISTLASYKGAQIFEALGLDNSIVDLCFTGTSSRIRGVTFEYLAQDAFSLHERGYPSRQTISKSVNLPESGEYHFRDGGYKHVNEPTAIASLQDTVRNKNDVSWQLYVKKEMEAIRDCTLRGLLELDFENSVSIPLEQVEPWTEIARRFASGAMSYGSISMEAHSTLAIAMNRLGAKSNCGEGGEDAERSAVQENGDTMRSAIKQVASARFGVTSYYLSDADEIQIKIAQGAKPGEGGELPAHKVSKDIAKTRHSTPNVGLISPPPHHDIYSIEDLKQLIYDLKCANPRAGISVKLVSEVGVGIVASGVAKAKADHILVSGHDGGTGAARWTSVKYAGLPWELGLAETHQTLVLNDLRRNVVVQTDGQLRTGFDIAVAVLLGAESFTLATVPLIAMGCVMLRRCHLNSCAVGIATQDPYLRSKFKGQPEHVINFFYYLIQDLRQIMAKLGFRTIDEMVGHSEKLKKRDDVNAKAINIDLSPILTPAHVIRPGVPTKFTKKQDHKLHTRLDNKLIDEAEVTLDRGLPVNIDASIINTDRALGSTLSYRVSKKFGEDGLPKDTVVVNIEGSAGQSFGAFLASGITFILNGDANDYVGKGLSGGIIVIKPPKDSKFKSDENVIVGNTCFYGATSGTAFISGSAGERFGVRNSGATIVVERIKGNNAFEYMTGGRAIVLSQMESLNAFSGATGGIAYCLTSDYDDFVGKINKDTVELESLCDPVEIAFVKNLIQEHWNYTQSDLAARILGNFNHYLKDFVKVIPTDYKKVLLKEKAEAAKAKAKATSEYLKKFRSNQEVDDEVNTLLIANQKAKEQEKKKSITISNKATLKEPKVVDLEDAVPDSKQLEKNSERIEKTRGFMIHKRRHETHRDPRTRVNDWKEFTNPITKKDAKYQTARCMDCGTPFCLSDTGCPLSNIIPKFNELLFKNQWKLALDKLLETNNFPEFTGRVCPAPCEGACTLGIIEDPVGIKSVERIIIDNAFKEGWIKPCPPSTRTGFTVGVIGSGPAGLACADMLNRAGHTVTVYERSDRCGGLLMYGIPNMKLDKAIVQRRIDLLSAEGIDFVTNTEIGKTISMDELKNKHNAVVYAIGSTIPRDLPIKGRELKNIDFAMQLLESNTKALLNKDLEIIREKIQGKKVIVVGGGDTGNDCLGTSVRHGAASVLNFELLPEPPVERAKDNPWPQWPRVMRVDYGHAEVKEHYGRDPREYCILSKEFIGNDEGEVTAIRTVRVEWKKSQSGVWQMVEIPNSEEIFEADIILLSMGFVGPELINGNDNEVKKTRRGTIATLDDSSYSIDGGKTFACGDCRRGQSLIVWAIQEGRKCAASVDKFLMDGTTYLPSNGGIVQRDYKLLKELASQV"},{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T19:38:40.000Z","updated_at":"2011-07-22T17:54:12.000Z","name":"Asparagine synthetase [glutamine-hydrolyzing] 2","uniprot_id":"P49090","uniprot_name":"ASNS2_YEAST","enzyme":true,"transporter":false,"gene_name":"ASN2","num_residues":572,"molecular_weight":"64592.5","theoretical_pi":"5.69","general_function":"Involved in asparagine synthase (glutamine-hydrolyzing) activity","specific_function":"ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate","reactions":[{"id":1330,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2261,"direction":"\u003e","locations":"","altext":"ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3712,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006185","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X83099","genbank_protein_id":"642347","gene_card_id":"ASN2","chromosome_location":"chromosome 7","locus":"YGR124W","synonyms":["Glutamine-dependent asparagine synthetase 2"],"enzyme_classes":["6.3.5.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" asparagine synthase (glutamine-hydrolyzing) activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" asparagine metabolic process"},{"category":"Process","description":" asparagine biosynthetic process"}],"pfams":[{"name":"Asn_synthase","identifier":"PF00733"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Asparagine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTGTGGTATCTTTGCAGCCTTCAAGCATGAAGATATTCACAACTTCAAACCAAAAGCTCTACAACTATCTAAAAAAATCAGACACCGTGGCCCAGATTGGTCAGGAAATGCCGTTATGAATTCCACCATTTTCGTTCACGAGAGGTTGGCTATTGTTGGTTTAGACTCCGGTGCCCAGCCAATCACTTCAGCTGATGGCGAATATATGCTTGGCGTTAATGGTGAGATCTACAACCACATCCAACTAAGGGAGATGTGCTCTGATTACAAGTTTCAAACTTTCAGTGACTGTGAACCCATCATACCGTTATATTTGGAACATGATATCGATGCTCCAAAATATCTGGACGGTATGTTCGCATTTTGTCTGTATGATTCCAAGAAAGACCGTATTGTCGCTGCAAGAGACCCTATCGGTGTTGTCACTTTATACATGGGGCGTTCTTCTCAGTCTCCAGAGACCGTTTATTTTGCCTCCGAATTAAAATGTCTAACTGACGTTTGTGACAGTATCATTTCGTTCCCTCCTGGTCATGTCTACGATTCTGAAACGGACAAGATTACTCGTTACTTTACCCCAGACTGGTTGGATGAAAAGCGTATCCCATCCACCCCAGTTGACTACCATGCTATCAGACACAGTTTAGAAAAGGCCGTTAGAAAGAGGCTAATGGCTGAAGTTCCATACGGTGTTCTTCTATCCGGTGGGCTGGACTCTTCTTTGATTGCTGCGATTGCTGCTCGTGAAACGGAAAAAGCTAATGCTGATGCTAACGAAGACAACAATGTTGACGAGAAGCAACTTGCAGGTATCGATGACCAAGGCCATCTACACACATCCGGTTGGTCTCGTTTGCATTCGTTTGCGATTGGTCTACCAAATGCACCTGATTTACAAGCGGCTAGAAAAGTCGCCAAATTCATTGGTTCTATCCACCATGAACACACTTTTACATTACAAGAAGGTTTGGATGCTTTGGACGACGTGATCTACCATTTGGAAACTTACGACGTTACCACTATCAGAGCTTCTACACCAATGTTCTTACTATCTAGAAAGATTAAGGCCCAAGGTGTCAAAATGGTTCTTTCTGGTGAAGGCTCGGACGAAATATTCGGTGGCTATCTATATTTCGCACAAGCACCTTCTGCTGCAGAATTTCACACCGAATCTGTGCAACGTGTCAAGAACTTGCATTTGGCAGATTGTTTGAGAGCTAATAAGTCCACGATGGCTTGGGGTCTAGAAGCTCGTGTTCCCTTCTTAGACAAAGACTTTTTGCAGCTATGTATGAACATTGATCCAAATGAAAAGATGATCAAGCCAAAGGAAGGACGTATCGAAAAATACATTTTAAGAAAGGCATTCGACACTACAGATGAACCAGATGTTAAGCCATACCTACCTGAAGAAATCTTATGGAGACAAAAGGAACAATTTTCCGATGGTGTTGGCTACTCATGGATTGACGGCCTAAGAGACACTGCTGAAAGGGCCATTTCTGACGCCATGTTTGCCAATCCAAAGGCTGATTGGGGCGACGATATTCCAACCACCAAAGAAGCTTACTGGTACAGGCTGAAGTTTGATGCTTGGTTTCCTCAAAAGACTGCGGCAGACACTGTCATGAGATGGATTCCAAAGGCCGATTGGGGTTGTGCCGAAGATCCTTCAGGTAGATACGCCAAAATACACGAAAAGCACGTCAGTGCTTAA","protein_sequence":"MCGIFAAFKHEDIHNFKPKALQLSKKIRHRGPDWSGNAVMNSTIFVHERLAIVGLDSGAQPITSADGEYMLGVNGEIYNHIQLREMCSDYKFQTFSDCEPIIPLYLEHDIDAPKYLDGMFAFCLYDSKKDRIVAARDPIGVVTLYMGRSSQSPETVYFASELKCLTDVCDSIISFPPGHVYDSETDKITRYFTPDWLDEKRIPSTPVDYHAIRHSLEKAVRKRLMAEVPYGVLLSGGLDSSLIAAIAARETEKANADANEDNNVDEKQLAGIDDQGHLHTSGWSRLHSFAIGLPNAPDLQAARKVAKFIGSIHHEHTFTLQEGLDALDDVIYHLETYDVTTIRASTPMFLLSRKIKAQGVKMVLSGEGSDEIFGGYLYFAQAPSAAEFHTESVQRVKNLHLADCLRANKSTMAWGLEARVPFLDKDFLQLCMNIDPNEKMIKPKEGRIEKYILRKAFDTTDEPDVKPYLPEEILWRQKEQFSDGVGYSWIDGLRDTAERAISDAMFANPKADWGDDIPTTKEAYWYRLKFDAWFPQKTAADTVMRWIPKADWGCAEDPSGRYAKIHEKHVSA"},{"created_at":"2011-05-24T19:39:43.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Dicarboxylic amino acid permease","uniprot_id":"P53388","uniprot_name":"DIP5_YEAST","enzyme":false,"transporter":true,"gene_name":"DIP5","num_residues":608,"molecular_weight":"68096.70313","theoretical_pi":"9.17","general_function":"Involved in transport","specific_function":"Can transport glutamate, aspartate, glutamine, asparagine, serine, alanine and glycine","reactions":[],"signal_regions":"None","transmembrane_regions":"91-111;120-142;157-177;202-222;232-252;286-306;323-343;373-393;424-444;455-475;502-522;531-551","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"X95802","genbank_protein_id":"1213234","gene_card_id":"DIP5","chromosome_location":"chromosome 16","locus":"YPL265W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAAGATGCCTCTAAAGAAGATGTTTACCAGCACGTCTCCTCGTAACTCTTCTTCTCTTGACAGTGATCATGACGCTTACTATTCGAAACAAAATCCTGACAATTTCCCTGTAAAGGAGCAAGAAATCTATAACATTGACCTGGAAGAAAACAATGTGTCCTCTCGTTCATCCACCTCTACATCACCTTCAGCAAGGGACGACTCTTTCGCAGTTCCAGATGGTAAAGACGAAAACACGCGGTTGAGGAAAGATTTAAAGGCAAGACATATTTCTATGATCGCCATTGGTGGTTCATTAGGTACAGGTCTGCTTATAGGTACAGGTACCGCCTTATTGACGGGTGGTCCGGTTGCGATGTTAATTGCATATGCCTTTGTCGGCCTTTTAGTCTTTTACACCATGGCCTGTCTTGGTGAAATGGCTTCTTACATTCCATTGGATGGTTTTACAAGTTATGCCTCACGTTACGTGGATCCTGCATTAGGTTTTGCTATTGGTTATACTTACCTTTTCAAATATTTCATCTTACCTCCCAACCAACTTACTGCTGCTGCTTTGGTCATTCAATATTGGATCAGCAGAGACCGTGTTAACCCTGGTGTGTGGATTACTATATTCTTGGTTGTTATTGTCGCTATCAATGTCGTCGGTGTAAAATTCTTTGGTGAATTTGAATTTTGGTTGTCCAGTTTCAAAGTCATGGTAATGTTGGGTCTAATCCTGTTACTATTTATTATTATGCTTGGTGGAGGTCCTAACCATGACCGCCTAGGGTTTAGATACTGGCGTGATCCTGGTGCGTTCAAAGAATATTCGACGGCTATCACTGGTGGTAAAGGTAAATTTGTTTCGTTCGTTGCTGTTTTCGTTTACAGTCTTTTCAGTTACACGGGTATTGAATTGACAGGTATCGTTTGTTCTGAAGCTGAGAATCCAAGAAAAAGTGTTCCAAAGGCAATTAAATTGACAGTTTACCGTATCATTGTTTTTTACCTATGCACCGTTTTCCTTTTGGGTATGTGCGTTGCATACAATGACCCTCGTTTACTTTCCACAAAAGGTAAGAGTATGTCTGCTGCGGCATCTCCATTCGTGGTTGCCATTCAAAACTCAGGTATTGAAGTCTTACCTCATATCTTCAATGCTTGTGTCTTGGTTTTCGTTTTCAGTGCTTGTAACTCAGATTTGTACGTTTCTTCCAGAAATTTATATGCGTTGGCAATTGATGGTAAAGCGCCAAAGATCTTCGCTAAGACAAGTAGATGGGGTGTTCCTTACAATGCTTTAATACTCTCCGTGCTGTTTTGTGGCTTGGCGTACATGAATGTGTCTTCAGGATCAGCAAAGATTTTCAACTACTTTGTTAACGTTGTTTCTATGTTCGGAATCTTGAGTTGGATCACCATTTTAATTGTTTACATCTACTTCGATAAAGCCTGCCGTGCTCAAGGGATTGACAAATCAAAATTTGCTTATGTCGCTCCTGGCCAACGTTATGGTGCTTATTTTGCTTTATTCTTCTGCATTTTGATTGCTTTAATCAAAAACTTCACTGTTTTCCTAGGTCATAAATTTGATTATAAAACATTCATCACCGGGTATATTGGCCTGCCTGTCTATATCATTTCTTGGGCTGGTTACAAATTGATATACAAAACCAAAGTGATAAAGTCTACCGACGTGGATTTGTACACATTTAAGGAAATATACGATAGAGAAGAAGAAGAGGGAAGAATGAAGGACCAAGAAAAGGAAGAGCGTTTAAAAAGTAACGGTAAAAATATGGAGTGGTTCTATGAAAAATTTTTGGGTAATATCTTCTAG","protein_sequence":"MKMPLKKMFTSTSPRNSSSLDSDHDAYYSKQNPDNFPVKEQEIYNIDLEENNVSSRSSTSTSPSARDDSFAVPDGKDENTRLRKDLKARHISMIAIGGSLGTGLLIGTGTALLTGGPVAMLIAYAFVGLLVFYTMACLGEMASYIPLDGFTSYASRYVDPALGFAIGYTYLFKYFILPPNQLTAAALVIQYWISRDRVNPGVWITIFLVVIVAINVVGVKFFGEFEFWLSSFKVMVMLGLILLLFIIMLGGGPNHDRLGFRYWRDPGAFKEYSTAITGGKGKFVSFVAVFVYSLFSYTGIELTGIVCSEAENPRKSVPKAIKLTVYRIIVFYLCTVFLLGMCVAYNDPRLLSTKGKSMSAAASPFVVAIQNSGIEVLPHIFNACVLVFVFSACNSDLYVSSRNLYALAIDGKAPKIFAKTSRWGVPYNALILSVLFCGLAYMNVSSGSAKIFNYFVNVVSMFGILSWITILIVYIYFDKACRAQGIDKSKFAYVAPGQRYGAYFALFFCILIALIKNFTVFLGHKFDYKTFITGYIGLPVYIISWAGYKLIYKTKVIKSTDVDLYTFKEIYDREEEEGRMKDQEKEERLKSNGKNMEWFYEKFLGNIF"},{"created_at":"2011-05-24T19:40:15.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Amidophosphoribosyltransferase","uniprot_id":"P04046","uniprot_name":"PUR1_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE4","num_residues":510,"molecular_weight":"56718.89844","theoretical_pi":"6.2","general_function":"Involved in amidophosphoribosyltransferase activity","specific_function":"5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O","reactions":[{"id":1578,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2263,"direction":"\u003e","locations":null,"altext":"5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"K02203","genbank_protein_id":"171009","gene_card_id":"ADE4","chromosome_location":"chromosome 13","locus":"YMR300C","synonyms":["ATase","Glutamine phosphoribosylpyrophosphate amidotransferase"],"enzyme_classes":["2.4.2.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" amidophosphoribosyltransferase activity"},{"category":"Process","description":" purine base biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" nucleobase metabolic process"},{"category":"Process","description":" nucleoside metabolic process"},{"category":"Process","description":" purine base metabolic process"}],"pfams":[{"name":"GATase_2","identifier":"PF00310"},{"name":"Pribosyltran","identifier":"PF00156"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGTGTGGTATTTTAGGTATTGTATTAGCAAACCAAACCACTCCAGTAGCTCCGGAGTTATGTGATGGATGCATTTTTCTACAACATCGTGGACAAGATGCAGCTGGTATAGCTACCTGTGGTTCTCGTGGTAGAGTCTGCCAATGTAAAGGTAATGGTATGGCTCGTGACGTATTTACCCAACGTGTTTCCGGTCTTGCTGGTTCCATGGGTATTGCCCACTTGAGATATCCTACACCGGGTCTTCGGCTAATTCTAGAAGCGCAACCATTTTACGTCAATAGTCCTTACGGTATTAACTTGGCACATAACGGTAACTTGGTGAATACTGCATCATTGAAGAGATATATGGATGAAGACGTTCATAGACATATTAACACGGACAGTGATTCGGAGTTACTATTGAATATTTTTGCTGCTGAACTGGAAAAACATAACAAGTACAGAGTTAACAATGAAGATGGTTTCTCCAACGCGTTAGAAGGTGTTTACCGTTTATGCCGTGGCGGTTATGCTTGCGTTGGTTTACTTGCCGGTTTTGCATTATTTGGTTTCAGAGATCCAAATGGTATTAGGCCATTATTGTTCGGTGAAAGAGAAAATCCGGACGGCACTAAGGACTATATGTTAGCTTCAGAAAGTGTTGTTTTCAAAGCTCACAACTTTACTAAATATCGTGACTTAAAGCCTGGCGAGGCAGGTATCATCCCTAAGAACTGTAGCAAAGGTGAACCTGAGTTCAAACAAGTGGTTCCTATTAACTCTTATAGACCTGATTTATTTGAATACGTATATTTCGCCAGACCGGACAGTGTCTTGGATGGAATATCAGTTTATCACACAAGATTGGCTATGGGTTCTAAATTAGCGCAAAATATTCTAAAGCAACTGAAGCCAGAAGATATTGATGTTGTTATTCCCGTCCCAGATACTGCAAGAACATGTGCACTAGAATGTGCTAATGTGTTAGGTAAGCCTTATAGAGAGGGCTTTGTTAAAAACAGATACGTGGGCAGGACATTTATCATGCCAAACCAGAGGGAAAGGGTTTCTTCAGTAAGGAGGAAGCTTAACCCTATGGAGTCTGAATTTAAGGGTAAGAAGGTTCTGATAGTGGATGATTCTATTGTCAGAGGTACTACTTCAAAAGAGATTGTTAACATGGCCAAGGAATCCGGTGCAACAAAGGTTTACTTCGCTTCAGCTGCCCCAGCCATTCGTTACAACCATATTTATGGTATTGACTTAACAGACACAAAGAACTTGATTGCTTATAACAGAACCGATGAAGAAGTGGCGGAAGTAATCGGTTGTGAAAGAGTCATTTACCAATCATTGGAAGATTTGATTGATTGTTGTAAAACTGATAAAATAACCAAATTCGAAGATGGTGTATTTACCGGAAATTATGTCACTGGTGTTGAAGACGGTTATATTCAAGAATTGGAAGAAAAACGTGAATCGATCGCAAATAATTCATCAGATATGAAGGCTGAAGTCGATATCGGATTATATAATTGTGCAGATTATTGA","protein_sequence":"MCGILGIVLANQTTPVAPELCDGCIFLQHRGQDAAGIATCGSRGRIYQCKGNGMARDVFTQQRVSGLAGSMGIAHLRYPTAGSSANSEAQPFYVNSPYGINLAHNGNLVNTASLKRYMDEDVHRHINTDSDSELLLNIFAAELEKHNKYRVNNEDVFHALEGVYRLCRGGYACVGLLAGFALFGFRDPNGIRPLLFGERENPDGTKDYMLASESVVFKAHNFTKYRDLKPGEAVIIPKNCSKGEPEFKQVVPINSYRPDLFEYVYFARPDSVLDGISVYHTRLAMGSKLAENILKQLKPEDIDVVIPVPDTARTCALECANVLGKPYREGFVKNRYVGRTFIMPNQRERVSSVRRKLNPMESEFKGKKVLIVDDSIVRGTTSKEIVNMAKESGATKVYFASAAPAIRYNHIYGIDLTDTKNLIAYNRTDEEVAEVIGCERVIYQSLEDLIDCCKTDKITKFEDGVFTGNYVTGVEDGYIQELEEKRESIANNSSDMKAEVDIGLYNCADY"},{"created_at":"2011-05-24T19:40:55.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"CTP synthase 2","uniprot_id":"P38627","uniprot_name":"URA8_YEAST","enzyme":true,"transporter":false,"gene_name":"URA8","num_residues":564,"molecular_weight":"63055.69922","theoretical_pi":"6.0","general_function":"Involved in CTP synthase activity","specific_function":"Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Plays an important role in the regulation of phospholipid synthesis","reactions":[{"id":1416,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1417,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2258,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + UTP + NH(3) = ADP + phosphate + CTP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z49603","genbank_protein_id":"1015810","gene_card_id":"URA8","chromosome_location":"chromosome 10","locus":"YJR103W","synonyms":["CTP synthetase 2","UTP--ammonia ligase 2"],"enzyme_classes":["6.3.4.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" CTP synthase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"CTP_synth_N","identifier":"PF06418"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGAAATACGTTGTTGTTTCTGGTGGTGTTATCTCAGGTATTGGTAAGGGTGTTTTAGCGTCCTCTACAGGGATGCTACTGAAAACCCTCGGCCTAAAGGTTACTTCCATCAAGATTGACCCATATATGAATATTGACGCCGGGACGATGTCTCCCTTGGAACATGGTGAGTGTTTTGTACTTGATGATGGTGGGGAAACGGACTTGGATCTCGGTAATTACGAGCGGTACCTCGGTATTACCTTAAGCAGGGACCACAACATCACCACCGGTAAGATATACTCCCACGTAATTTCCAGAGAAAGGAGAGGTGATTATTTAGGTAAGACAGTTCAAATTGTTCCTCATTTGACTAACGCAATTCAGGATTGGATTCAACGTGTTTCAAAAATTCCAGTGGATGACACAGGATTAGAACCAGACGTCTGTATCATCGAGTTAGGTGGTACGGTCGGTGACATTGAGAGTGCGCCCTTCGTGGAAGCATTACGACAATTTCAGTTCGAAGTTGGAAGAGAGAATTTCGCCCTGATCCATGTTTCACTTGTGCCCGTCATTCATGGTGAACAGAAGACGAAACCCACCCAAGCAGCAATCAAAGATTTAAGGTCATTAGGGCTTATTCCCGATATGATTGCCTGCAGATGCAGCGAAGAACTTAACAGGAGCACTATTGACAAGATTGCCATGTTTTGCCATGTGGGGCCGGAGCAAGTGGTCAACGTTCATGATGTTAACTCCACGTACCACGTTCCCTTATTGCTGCTAAAGCAACATATGATCGACTACCTCCATTCAAGGTTGAAATTAGGTGAAGTGCCTCTAACCTTGGAAGACAAGGAAAGAGGGTCTCAATTATTGACTAACTGGGAAAACATGACCAAAAACCTAGATGATTCTGATGATGTTGTCAAGATTGCTCTTGTGGGAAAATACACTAATTTGAAGGATTCCTACCTATCTGTGACCAAATCCTTAGAACACGCAAGCATGAAGTGCCGTCGTCAGCTAGAAATCCTCTGGGTAGAGGCAAGTAACCTAGAGCCCGAAACTCAAGAGGTGGACAAGAACAAGTTCCACGATTCATGGAATAAGCTCAGTTCCGCCGACGGAATTTTGGTTCCTGGTGGATTTGGCACGAGAGGTATTGAAGGTATGATTCTTGCTGCCAAATGGGCCCGTGAATCCGGTGTTCCCTTTCTTGGTGTCTGTCTTGGATTACAAGTTGCCGCTATCGAGTTCGCCCGCAATGTGATAGGCCGCCCAAACAGCAGTTCTACAGAATTTTTGGACGAGACACTACTAGCTCCTGAAGACCAAGTAGTCATATACATGCCCGAGATCGACAAGGAACACATGGGTGGCACGATGAGATTGGGTTTGAGGCCTACCATTTTCCAACCGAACTCAGAATGGAGCAACATAAGGAAGCTTTATGGTGAAGTTAATGAGGTGCATGAGAGACATCGTCATCGCTATGAGATAAACCCGAAAATAGTGAATGATATGGAGTCTCGTGGCTTTATTTTTGTTGGTAAGGACGAGACGGGCCAGCGTTGCGAAATATTCGAATTGAAAGGCCATCCATACTACGTGGGCACTCAATACCATCCAGAGTATACATCGAAGGTGCTGGAACCATCAAGACCGTTTTGGGGGCTTGTGGCCGCAGCTCCGGCACACTTGGTGAAGTGA","protein_sequence":"MKYVVVSGGVISGIGKGVLASSTGMLLKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLDDGGETDLDLGNYERYLGITLSRDHNITTGKIYSHVISRERRGDYLGKTVQIVPHLTNAIQDWIQRVSKIPVDDTGLEPDVCIIELGGTVGDIESAPFVEALRQFQFEVGRENFALIHVSLVPVIHGEQKTKPTQAAIKDLRSLGLIPDMIACRCSEELNRSTIDKIAMFCHVGPEQVVNVHDVNSTYHVPLLLLKQHMIDYLHSRLKLGEVPLTLEDKERGSQLLTNWENMTKNLDDSDDVVKIALVGKYTNLKDSYLSVTKSLEHASMKCRRQLEILWVEASNLEPETQEVDKNKFHDSWNKLSSADGILVPGGFGTRGIEGMILAAKWARESGVPFLGVCLGLQVAAIEFARNVIGRPNSSSTEFLDETLLAPEDQVVIYMPEIDKEHMGGTMRLGLRPTIFQPNSEWSNIRKLYGEVNEVHERHRHRYEINPKIVNDMESRGFIFVGKDETGQRCEIFELKGHPYYVGTQYHPEYTSKVLEPSRPFWGLVAAAPAHLVK"},{"created_at":"2011-05-24T19:41:28.000Z","updated_at":"2011-07-22T17:53:48.000Z","name":"Aminodeoxychorismate synthase","uniprot_id":"P37254","uniprot_name":"PABS_YEAST","enzyme":true,"transporter":false,"gene_name":"ABZ1","num_residues":787,"molecular_weight":"88543.5","theoretical_pi":"5.55","general_function":"Involved in biosynthetic process","specific_function":"Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis","reactions":[{"id":1189,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2264,"direction":"\u003e","locations":"Cytoplasm","altext":"Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":4145,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006446","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY693029","genbank_protein_id":"51013509","gene_card_id":"ABZ1","chromosome_location":"chromosome 14","locus":"YNR033W","synonyms":["ADC synthase","P-aminobenzoic acid synthase","PABA synthase","Para-aminobenzoate synthase"],"enzyme_classes":["2.6.1.85"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" anthranilate synthase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamine metabolic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"Anth_synt_I_N","identifier":"PF04715"},{"name":"Chorismate_bind","identifier":"PF00425"}],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGCTGTCCGATACAATTGACACAAAGCAACAACAGCAACAGCTTCATGTCCTGTTCATAGACTCTTATGATTCATTCACCTACAATGTAGTGAGACTAATTGAACAACAAACTGATATCTCACCGGGAGTCAACGCCGTGCACGTGACGACGGTACATAGTGATACGTTCCAATCTATGGATCAGCTATTGCCACTTTTGCCGCTTTTTGATGCTATCGTTGTTGGCCCAGGACCTGGGAATCCCAACAATGATGCACAAGATATGGGTATAATATCTGAGCTTTTCGAGAATGCCAATGGAAAGTTAGATGAAGTTCCAATATTGGGTATATGTCTTGGGTTCCAAGCAATGTGCTTGGCTCAAGGTGCTGATGTCAGTGAGCTAAATACTATCAAGCATGGGCAAGTGTATGAAATGCATTTAAACGATGCAGCCAGAGCTTGTGGCCTTTTTTCTGGTTATCCCGATACGTTCAAATCTACGAGGTACCATTCATTGCATGTCAATGCCGAAGGCATTGACACCCTTTTGCCCTTATGCACAACCGAAGATGAGAACGGTATTCTTTTGATGAGTGCTCAAACGAAAAATAAGCCATGGTTTGGCGTACAGTACCACCCGGAGTCATGTTGTTCAGAATTGGGGGGGCTGTTAGTCAGTAACTTTCTCAAGTTGAGTTTCATAAATAACGTGAAGACAGGAAGGTGGGAAAAGAAGAAACTTAATGGAGAGTTTTCCGATATCCTATCTCGATTGGATAGGACTATTGATAGAGACCCCATATACAAGGTAAAAGAGAAATATCCGAAGGGCGAGGACACAACTTACGTTAAGCAGTTCGAGGTCTCTGAAGACCCGAAATTGACATTTGAAATTTGCAACATCATACGAGAAGAAAAATTTGTCATGTCATCTTCTGTGATTAGTGAAAATACGGGTGAATGGTCTATCATTGCTTTACCAAACTCCGCATCCCAGGTATTCACTCATTATGGAGCTATGAAAAAGACTACAGTTCATTATTGGCAAGATAGTGAAATTAGTTACACCTTGTTGAAAAAGTGTCTAGATGGTCAAGATTCGGATTTGCCTGGCTCCCTTGAGGTAATACATGAAGATAAATCCCAATTTTGGATCACTTTGGGTAAATTTATGGAGAATAAAATAATCGATAACCACAGAGAAATACCTTTTATTGGAGGTCTTGTTGGCATTTTAGGTTATGAAATAGGTCAGTACATTGCATGCGGCCGTTGCAATGATGATGAGAATTCCCTTGTTCCCGACGCCAAACTAGTTTTTATCAACAATAGTATAGTCATTAATCACAAGCAAGGGAAGCTTTATTGTATTTCTCTGGATAATACATTTCCAGTGGCATTAGAACAATCATTAAGGGACAGTTTTGTTAGAAAGAAGAATATTAAGCAATCCCTGTCCTGGCCCAAGTATCTTCCAGAGGAGATAGACTTCATTATAACTATGCCCGATAAACTTGACTACGCTAAGGCGTTTAAGAAATGTCAGGATTATATGCATAAGGGTGATTCTTATGAAATGTGTCTCACAACGCAAACCAAAGTTGTACCATCTGCGGTGATAGAACCCTGGAGGATTTTCCAGACCTTGGTACAAAGAAACCCGGCTCCATTTTCAAGTTTTTTTGAGTTTAAAGACATTATTCCCCGCCAAGATGAAACGCCTCCAGTTTTGTGCTTCTTAAGTACTTCTCCAGAAAGGTTTTTGAAGTGGGATGCAGACACATGCGAGCTACGTCCCATCAAGGGAACTGTGAAAAAAGGACCGCAAATGAACTTGGCAAAAGCCACACGAATCCTGAAGACACCAAAAGAATTTGGTGAGAACTTAATGATTTTGGACTTAATCAGAAATGACCTTTACGAGTTGGTTCCTGACGTTCGGGTGGAGGAGTTCATGTCCGTGCAAGAATATGCCACCGTTTACCAACTCGTTAGCGTCGTAAAGGCACATGGATTGACCTCTGCCAGTAAGAAGACGAGATATTCAGGCATTGATGTCCTTAAACACTCGCTTCCTCCGGGATCTATGACGGGAGCCCCCAAGAAGATTACTGTGCAATTATTGCAGGACAAGATAGAAAGCAAGCTAAACAAACATGTCAATGGTGGAGCACGTGGTGTTTACAGCGGTGTCACGGGATATTGGTCTGTGAATTCCAACGGAGATTGGTCTGTTAACATTAGATGTATGTATTCCTACAACGGCGGAACCAGCTGGCAACTCGGTGCAGGGGGGGCCATAACAGTCTTAAGCACACTAGATGGCGAACTAGAGGAAATGTACAACAAGTTGGAGAGCAACTTACAAATTTTCATGTAG","protein_sequence":"MLSDTIDTKQQQQQLHVLFIDSYDSFTYNVVRLIEQQTDISPGVNAVHVTTVHSDTFQSMDQLLPLLPLFDAIVVGPGPGNPNNGAQDMGIISELFENANGKLDEVPILGICLGFQAMCLAQGADVSELNTIKHGQVYEMHLNDAARACGLFSGYPDTFKSTRYHSLHVNAEGIDTLLPLCTTEDENGILLMSAQTKNKPWFGVQYHPESCCSELGGLLVSNFLKLSFINNVKTGRWEKKKLNGEFSDILSRLDRTIDRDPIYKVKEKYPKGEDTTYVKQFEVSEDPKLTFEICNIIREEKFVMSSSVISENTGEWSIIALPNSASQVFTHYGAMKKTTVHYWQDSEISYTLLKKCLDGQDSDLPGSLEVIHEDKSQFWITLGKFMENKIIDNHREIPFIGGLVGILGYEIGQYIACGRCNDDENSLVPDAKLVFINNSIVINHKQGKLYCISLDNTFPVALEQSLRDSFVRKKNIKQSLSWPKYLPEEIDFIITMPDKLDYAKAFKKCQDYMHKGDSYEMCLTTQTKVVPSAVIEPWRIFQTLVQRNPAPFSSFFEFKDIIPRQDETPPVLCFLSTSPERFLKWDADTCELRPIKGTVKKGPQMNLAKATRILKTPKEFGENLMILDLIRNDLYELVPDVRVEEFMSVQEYATVYQLVSVVKAHGLTSASKKTRYSGIDVLKHSLPPGSMTGAPKKITVQLLQDKIESKLNKHVNGGARGVYSGVTGYWSVNSNGDWSVNIRCMYSYNGGTSWQLGAGGAITVLSTLDGELEEMYNKLESNLQIFM"},{"created_at":"2011-05-24T19:42:13.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Glutamine-dependent NAD(+) synthetase","uniprot_id":"P38795","uniprot_name":"NADE_YEAST","enzyme":true,"transporter":false,"gene_name":"QNS1","num_residues":714,"molecular_weight":"80684.89844","theoretical_pi":"6.51","general_function":"Involved in NAD+ synthase (glutamine-hydrolyzing) activity","specific_function":"ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate","reactions":[{"id":1763,"direction":"\u003e","locations":"cytoplasm;nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2265,"direction":"\u003e","locations":"Cytoplasmic","altext":"ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":4183,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006484","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"U10556","genbank_protein_id":"500832","gene_card_id":"QNS1","chromosome_location":"chromosome 8","locus":"YHR074W","synonyms":["NAD(+) synthase [glutamine-hydrolyzing]"],"enzyme_classes":["6.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" NAD+ synthase (glutamine-hydrolyzing) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pyridine nucleotide biosynthetic process"},{"category":"Process","description":" nicotinamide nucleotide biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" NAD biosynthetic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"NAD_synthase","identifier":"PF02540"},{"name":"CN_hydrolase","identifier":"PF00795"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCACATCTTATCACTTTAGCTACATGCAACTTGAATCAATGGGCCCTAGATTTTGAAGGTAATAGAGACCGTATCCTACAGTCCATTAAGATTGCCAAAGAGAGGGGTGCCAGGTTACGTGTCGGCCCAGAACTGGAAATAACTGGCTACGGATGTTTAGATCATTTTTTAGAAAATGACGTTTGCCTTCATTCATGGGAAATGTATGCTCAAATCATTAAGAATAAAGAAACCCATGGATTAATACTTGACATTGGTATGCCCGTTCTACACAAGAATGTTCGTTATAATTGTCGTTTGTTATCCTTGGATGGTGAGATATTGTTCATAAGACCTAAGATTTGGTTAGCTAATGATGGTAACTATAGGGAAATGAGATTTTTCACACCTTGGATGAAACCTGGCGTGGTGGAGGACTTTATCCTTCCACCTGAGATTCAGAAAGTTACCGGCCAGAGACTTGTGCCATTTGGGGACGCTGTGATAAATTCATTGGATACATGCATTGGTACAGAAACTTGTGAAGAATTGTTTACACCTCAATCCCCCCACATCGCCATGTCTTTAGATGGTGTGGAAATCATGACAAACTCATCTGGTTCTCATCATGAACTGCGTAAGTTAAATAAAAGGTTAGACCTAATTTTAAATGCCACTAAACGTTGTGGTGGTGTTTACTTGTATGCAAATCAAAGAGGTTGTGATGGTGACAGATTATATTATGATGGCTGTGCACTAATTGCCATCAATGGTACAATTGTAGCCCAAGGTTCACAATTTTCGCTAGATGATGTGGAAGTAGTTACTGCTACTGTGGACCTAGAAGAGGTGAGGAGTTATCGTGCAGCTGTCATGTCTCGTGGCCTACAAGCCTCCTTGGCAGAAATAAAGTTCAAGCGTATTGATATTCCTGTAGAATTGGCTTTAATGACCTCCAGATTTGATCCTACAGTGTGTCCAACAAAAGTCCGCGAGCCTTTCTATCACTCTCCTGAGGAAGAAATTGCACTGGGACCTGCTTGCTGGATGTGGGATTATTTAAGACGTTGTAACGGAACAGGGTTTTTCCTTCCCTTATCTGGGGGCATTGACTCTTGTGCAACTGCAATGATTGTCCACTCTATGTGCCGTTTAGTGACCGACGCTGCTCAAAATGGAAATGAGCAAGTTATCAAAGACGTTCGTAAGATAACACGTAGCGGCGATGATTGGATTCCAGACAGTCCACAGGATCTAGCCTCAAAAATATTTCACTCCTGTTTCATGGGTACGGAAAATTCATCCAAGGAGACAAGAAACAGAGCAAAGGACCTTTCCAATGCAATTGGATCTTACCACGTGGATTTAAAGATGGACTCATTGGTATCCAGTGTGGTGTCCTTATTCGAAGTAGCCACTGGCAAAAAACCAATATACAAAATATTTGGGGGATCTCAAATCGAGAACTTGGCTTTACAAAACATCCAGGCGCGTCTAAGAATGGTTCTTTCTTATCTTTTTGCGCAACTGTTGCCGTGGGTTCGTGGTATCCCAAACTCGGGTGGATTGTTAGTACTTGGTAGCGCAAATGTTGATGAGTGCTTACGTGGGTATCTAACAAAATATGACTGCTCCTCCGCAGATATCAACCCTATTGGGGGTATTTCAAAAACTGACTTGAAAAGATTCATTGCCTACGCATCAAAACAATATAACATGCCAATCTTGAATGACTTTTTAAACGCTACACCAACTGCAGAATTAGAACCTATGACTAAAGATTACGTTCAATCGGATGAGATAGATATGGGGATGACGTATGAAGAATTGGGCGTGTTTGGTTACCTAAGAAAGGTTGAAAAATGTGGTCCTTATTCTATGTTCTTAAAACTTCTTCATCAATGGTCCCCAAAGTTAACACCTCGTCAAATATCTGAAAAGGTGAAAAGATTTTTCTTCTTCTATGCCATCAACAGACACAAGCAAACTGTTTTAACTCCTAGTTATCATGCTGAACAGTATTCACCAGAAGACAACAGATTTGACTTACGTCCTTTCTTAATCAACCCAAGATTTCCATGGGCTTCAAGAAAAATTGATGAAGTTGTCGAGCAGTGTGAAGCACATAAAGGCTCAACGCTTGACATTATGTCTATTGATTAG","protein_sequence":"MSHLITLATCNLNQWALDFEGNRDRILQSIKIAKERGARLRVGPELEITGYGCLDHFLENDVCLHSWEMYAQIIKNKETHGLILDIGMPVLHKNVRYNCRLLSLDGEILFIRPKIWLANDGNYREMRFFTPWMKPGVVEDFILPPEIQKVTGQRLVPFGDAVINSLDTCIGTETCEELFTPQSPHIAMSLDGVEIMTNSSGSHHELRKLNKRLDLILNATKRCGGVYLYANQRGCDGDRLYYDGCALIAINGTIVAQGSQFSLDDVEVVTATVDLEEVRSYRAAVMSRGLQASLAEIKFKRIDIPVELALMTSRFDPTVCPTKVREPFYHSPEEEIALGPACWMWDYLRRCNGTGFFLPLSGGIDSCATAMIVHSMCRLVTDAAQNGNEQVIKDVRKITRSGDDWIPDSPQDLASKIFHSCFMGTENSSKETRNRAKDLSNAIGSYHVDLKMDSLVSSVVSLFEVATGKKPIYKIFGGSQIENLALQNIQARLRMVLSYLFAQLLPWVRGIPNSGGLLVLGSANVDECLRGYLTKYDCSSADINPIGGISKTDLKRFIAYASKQYNMPILNDFLNATPTAELEPMTKDYVQSDEIDMGMTYEELGVFGYLRKVEKCGPYSMFLKLLHQWSPKLTPRQISEKVKRFFFFYAINRHKQTVLTPSYHAEQYSPEDNRFDLRPFLINPRFPWASRKIDEVVEQCEAHKGSTLDIMSID"},{"created_at":"2011-05-24T19:42:23.000Z","updated_at":"2011-05-24T19:42:23.000Z","name":"Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial","uniprot_id":"P53260","uniprot_name":"GATF_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":183,"molecular_weight":"20786.80078","theoretical_pi":"10.15","general_function":"Involved in ATP binding","specific_function":"Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln)","reactions":[{"id":2257,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY558325","genbank_protein_id":"45270540","gene_card_id":null,"chromosome_location":null,"locus":"YGR102C","synonyms":["Glu-ADT subunit F","gatF"],"enzyme_classes":["6.3.5.-"],"go_classes":[],"pfams":[],"pathways":[],"gene_sequence":"ATGTACAAAACATGGCGTCTATGCGGAACACATACAGTGGGTGGGTTATGCCATGATGGAAGTCATCGGTTCGTATCTACGGGAGGGGCAAAGATTGGTAAAAAATTTGAAAATATGAATCAAATAAGGGATTATTTATCAAGACCTGTATGGTCCGTCCACGAATATTTAGGCATAAACACTAAAGAGGAAAAACTAGAGCCACCGTCTGCTGAAGCTGTAAAAAAATTGTTGCGGTTATCAGGTCTTCCCTTGGAAGGAGCAGATATTAAAGAAATTCAAATGCGACTTGCCAAGCAATTATCATTCATCAACAAACTCCATAACATACCTGTCGAAGGTGAAAAGCACACCAAGGAATATGATGCTCGGTTGGTGCAAAGAAATACGAAACAGCTGAACTACACAAAGCTACTTGAAGGCATCAGCCACCAAAAGCAGGATGCTGAGCTAGGAGAAGTTAGCGGATCTTGGAAAGCAACTGGACTTGCCGCGGAATCCAAAAATGCATATTTTGTTGTCAAAGAGGGACTACTCAAAAACAGGAAGTAA","protein_sequence":"MYKTWRLCRTHTVGGLCHDGSHRFVSTGGAKIGKKFENMNQIRDYLSRPVWSVHEYLGINTKEEKLEPPSAEAVKKLLRLSGLPLEGADIKEIQMRLAKQLSFINKLHNIPVEGEKHTKEYDARLVQRNTKQLNYTKLLEGISHQKQDAELGEVSGSWKATGLAAESKNAYFVVKEGLLKNRK"},{"created_at":"2011-05-24T19:55:26.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Probable kynurenine--oxoglutarate transaminase BNA3","uniprot_id":"P47039","uniprot_name":"BNA3_YEAST","enzyme":true,"transporter":false,"gene_name":"BNA3","num_residues":444,"molecular_weight":"50081.89844","theoretical_pi":"6.53","general_function":"Involved in 1-aminocyclopropane-1-carboxylate synthase activity","specific_function":"Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA)","reactions":[{"id":1756,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2282,"direction":"\u003e","locations":"Cytoplasm. Mitochondrion","altext":"L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3723,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006249","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Mitochondrion","genbank_gene_id":"Z49335","genbank_protein_id":"1008205","gene_card_id":"BNA3","chromosome_location":"chromosome 10","locus":"YJL060W","synonyms":["Biosynthesis of nicotinic acid protein 3","Kynurenine aminotransferase"],"enzyme_classes":["2.6.1.7"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" carbon-sulfur lyase activity"},{"category":"Function","description":" 1-aminocyclopropane-1-carboxylate synthase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"L-alanine metabolism","kegg_map_id":null}],"gene_sequence":"ATGAAACAACGATTCATTCGTCAATTTACGAACCTAATGTCTACTTCGAGACCGAAAGTTGTTGCCAACAAATATTTCACTTCTAACACTGCCAAAGATGTTTGGTCGCTAACCAATGAAGCCGCTGCAAAAGCTGCCAATAACTCCAAAAACCAAGGCCGTGAACTTATTAATTTAGGCCAAGGCTTTTTTTCATATTCCCCTCCTCAATTCGCCATTAAGGAGGCTCAGAAAGCCCTAGACATTCCAATGGTCAATCAATATTCTCCAACTAGAGGTCGACCTTCATTAATTAATTCCTTGATTAAGTTGTATTCTCCTATTTATAACACAGAATTGAAAGCGGAAAATGTTACCGTAACAACAGGTGCCAATGAAGGTATACTTTCTTGCTTGATGGGGCTTTTGAACGCTGGCGACGAGGTTATTGTTTTTGAACCTTTCTTTGACCAATATATTCCAAATATCGAACTTTGCGGTGGTAAAGTTGTTTACGTCCCCATAAATCCTCCAAAGGAATTGGATCAAAGGAATACTAGAGGTGAAGAATGGACCATTGACTTTGAGCAGTTCGAAAAAGCGATTACATCCAAGACAAAAGCTGTCATTATCAATACCCCTCACAACCCAATTGGTAAAGTTTTCACGCGCGAGGAATTAACCACTTTAGGTAACATTTGCGTCAAGCACAACGTTGTGATTATATCTGATGAAGTCTATGAACACCTTTACTTCACTGATTCTTTCACTAGAATTGCCACACTCTCTCCAGAAATTGGGCAACTAACCTTAACGGTCGGTTCTGCCGGTAAATCGTTTGCTGCTACTGGTTGGAGAATTGGTTGGGTCTTATCCTTGAACGCAGAGTTGTTAAGTTATGCAGCTAAGGCACATACAAGAATTTGTTTTGCATCTCCATCCCCTCTACAGGAAGCTTGTGCAAACTCTATTAACGACGCTTTAAAAATTGGGTATTTTGAAAAAATGAGACAGGAATATATCAACAAATTCAAAATTTTCACATCGATCTTTGATGAATTGGGACTACCATATACAGCTCCAGAGGGTACATATTTTGTCCTCGTTGATTTCTCTAAAGTGAAAATTCCCGAGGACTATCCCTACCCAGAGGAGATCCTGAATAAGGGAAAAGATTTTCGCATTTCTCACTGGTTGATCAATGAATTAGGTGTGGTTGCCATTCCACCAACTGAATTCTATATCAAAGAGCACGAAAAGGCTGCTGAGAATTTGTTAAGGTTTGCAGTTTGTAAAGATGATGCTTATCTAGAAAATGCCGTAGAGAGATTAAAACTACTCAAGGACTACTTATAA","protein_sequence":"MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL"},{"created_at":"2011-05-24T20:18:23.000Z","updated_at":"2011-05-27T14:56:00.000Z","name":"Saccharopine dehydrogenase [NADP+, L-glutamate-forming]","uniprot_id":"P38999","uniprot_name":"LYS9_YEAST","enzyme":true,"transporter":false,"gene_name":"LYS9","num_residues":446,"molecular_weight":"48917.30078","theoretical_pi":"4.87","general_function":"Involved in binding","specific_function":"N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-glutamate + L-2-aminoadipate 6-semialdehyde + NADPH","reactions":[{"id":1960,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2310,"direction":"\u003e","locations":null,"altext":"N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-glutamate + L-2-aminoadipate 6-semialdehyde + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":4178,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006477","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X77363","genbank_protein_id":"453186","gene_card_id":"LYS9","chromosome_location":"chromosome 14","locus":"YNR050C","synonyms":["Saccharopine reductase"],"enzyme_classes":["1.5.1.10"],"go_classes":[],"pfams":[{"name":"Saccharop_dh","identifier":"PF03435"}],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Lysine degradation","kegg_map_id":"00310"},{"name":"lysine metabolism","kegg_map_id":null}],"gene_sequence":"ATGGGAAAGAACGTTTTGTTGCTAGGATCTGGTTTTGTTGCACAACCTGTTATCGACACATTGGCTGCTAATGATGACATCAATGTCACTGTCGCATGTAGAACATTAGCCAATGCGCAAGCATTGGCCAAGCCCTCTGGATCCAAGGCTATTTCATTGGATGTTACCGATGACAGTGCCTTAGACAAAGTTCTGGCTGATAACGATGTTGTCATCTCTTTGATTCCATACACCTTCCATCCAAATGTGGTAAAGAGCGCCATCAGAACAAAGACCGATGTCGTCACTTCCTCTTACATCTCACCTGCCTTAAGAGAATTGGAACCAGAAATCGTAAAGGCAGGTATTACAGTTATGAACGAAATTGGGTTGGATCCAGGTATCGACCACTTGTATGCGGTCAAGACTATTGATGAAGTTCACAGAGCTGGTGGTAAGCTAAAGTCATTCTTGTCATACTGTGGTGGTTTACCAGCTCCTGAAGACTCTGATAATCCATTAGGATACAAATTTTCATGGTCCTCCAGAGGTGTGCTACTGGCTTTAAGAAACTCTGCTAAATACTGGAAAGACGGAAAGATTGAAACTGTTTCTTCCGAAGACTTAATGGCCACTGCTAAGCCTTACTTCATCTACCCAGGTTATGCATTCGTTTGCTACCCAAATAGAGACTCTACCCTTTTCAAGGATCTTTATCATATTCCAGAAGCCGAAACGGTCATTAGAGGTACTTTGAGATATCAAGGTTTCCCAGAATTTGTTAAGGCTTTAGTTGACATGGGTATGTTGAAGGATGATGCTAACGAAATCTTCAGCAAGCCAATTGCCTGGAACGAAGCACTAAAACAATATTTAGGTGCCAAGTCTACTTCTAAAGAAGATTTGATTGCTTCCATTGACTCAAAGGCTACTTGGAAAGATGATGAAGATAGAGAAAGAATCCTTTCCGGGTTTGCTTGGTTAGGCTTGTTCTCTGACGCAAAGATCACACCAAGAGGTAATGCTTTAGACACTCTATGTGCACGTTTAGAAGAACTAATGCAATATGAAGACAATGAAAGAGATATGGTTGTACTACAACACAAATTCGGTATTGAATGGGCTGATGGAACTACCGAAACAAGAACATCCACTTTAGTTGACTATGGTAAGGTTGGTGGTTACAGTTCTATGGCCGCTACTGTTGGTTATCCAGTTGCCATTGCAACGAAATTCGTCTTAGATGGTACAATCAAGGGACCAGGCTTACTAGCGCCATACTCACCAGAGATTAATGATCCAATCATGAAAGAACTAAAGGACAAGTACGGCATCTATCTAAAGGAAAAGACAGTGGCTTAA","protein_sequence":"MGKNVLLLGSGFVAQPVIDTLAANDDINVTVACRTLANAQALAKPSGSKAISLDVTDDSALDKVLADNDVVISLIPYTFHPNVVKSAIRTKTDVVTSSYISPALRELEPEIVKAGITVMNEIGLDPGIDHLYAVKTIDEVHRAGGKLKSFLSYCGGLPAPEDSDNPLGYKFSWSSRGVLLALRNSAKYWKDGKIETVSSEDLMATAKPYFIYPGYAFVCYPNRDSTLFKDLYHIPEAETVIRGTLRYQGFPEFVKALVDMGMLKDDANEIFSKPIAWNEALKQYLGAKSTSKEDLIASIDSKATWKDDEDRERILSGFAWLGLFSDAKITPRGNALDTLCARLEELMQYEDNERDMVVLQHKFGIEWADGTTETRTSTLVDYGKVGGYSSMAATVGYPVAIATKFVLDGTIKGPGLLAPYSPEINDPIMKELKDKYGIYLKEKTVA"},{"created_at":"2011-05-24T20:44:30.000Z","updated_at":"2011-07-22T17:53:56.000Z","name":"Acetylornithine aminotransferase, mitochondrial","uniprot_id":"P18544","uniprot_name":"ARGD_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG8","num_residues":423,"molecular_weight":"46681.10156","theoretical_pi":"7.62","general_function":"Involved in transaminase activity","specific_function":"N(2)-acetyl-L-ornithine + 2-oxoglutarate = N- acetyl-L-glutamate 5-semialdehyde + L-glutamate","reactions":[{"id":1247,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2338,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3773,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006295","source":"Smpdb"},{"id":3773,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006295","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"M32795","genbank_protein_id":"171083","gene_card_id":"ARG8","chromosome_location":"chromosome 15","locus":"YOL140W","synonyms":["ACOAT"],"enzyme_classes":["2.6.1.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine metabolic process"}],"pfams":[{"name":"Aminotran_3","identifier":"PF00202"}],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"4-aminobutanoate degradation","kegg_map_id":null}],"gene_sequence":"ATGTTTAAAAGATATTTATCCAGTACGTCATCAAGAAGATTTACAAGCATTTTAGAGGAAAAGGCCTTTCAAGTGACCACTTACTCTAGACCTGAAGATCTATGTATAACTAGAGGTAAAAATGCAAAGCTGTATGATGACGTGAATGGTAAAGAATATATCGATTTCACCGCAGGTATTGCGGTGACCGCATTAGGCCATGCAAATCCTAAAGTGGCAGAAATTCTGCACCATCAGGCTAACAAACTGGTTCATTCCTCCAACCTTTACTTCACTAAGGAATGTTTGGATTTAAGTGAAAAGATTGTTGAAAAGACCAAGCAATTCGGTGGTCAACACGACGCCTCAAGAGTATTTTTATGTAATTCTGGTACGGAAGCAAATGAAGCTGCTTTGAAGTTTGCAAAGAAACATGGTATAATGAAAAATCCTAGCAAGCAAGGCATTGTTGCATTTGAGAACTCTTTTCATGGCCGTACTATGGGCGCTTTATCTGTCACTTGGAATAGTAAATATAGAACTCCTTTTGGGGATTTGGTTCCCCATGTCTCATTCTTAAATTTGAATGACGAAATGACCAAACTACAAAGTTATATCGAGACCAAAAAGGACGAGATTGCTGGTTTAATTGTCGAGCCCATACAAGGTGAAGGTGGGGTTTTTCCCGTAGAAGTTGAAAAGCTAACCGGATTGAAGAAAATATGTCAAGATAATGATGTGATTGTCATTCATGATGAAATTCAATGCGGTTTGGGCCGTTCAGGTAAACTATGGGCTCATGCTTATTTACCAAGTGAGGCTCATCCGGATATTTTTACATCTGCCAAAGCATTGGGAAATGGCTTCCCCATCGCTGCCACCATCGTCAATGAAAAAGTTAATAATGCTTTGAGAGTTGGTGACCACGGCACCACGTATGGTGGTAATCCGCTGGCCTGTTCTGTAAGCAACTATGTTTTGGATACCATAGCAGACGAAGCTTTTTTGAAACAAGTCTCTAAGAAGAGTGATATCTTACAAAAGCGCTTGCGCGAAATTCAAGCCAAATATCCAAATCAAATAAAGACTATCAGAGGAAAAGGTTTGATGCTTGGTGCTGAGTTCGTCGAACCACCCACCGAGGTCATCAAAAAGGCCAGAGAATTGGGACTTTTGATCATTACCGCTGGTAAGAGTACCGTTAGATTTGTTCCCGCATTAACGATTGAAGACGAACTAATCGAAGAAGGGATGGATGCTTTTGAAAAGGCTATTGAAGCGGTTTACGCTTAA","protein_sequence":"MFKRYLSSTSSRRFTSILEEKAFQVTTYSRPEDLCITRGKNAKLYDDVNGKEYIDFTAGIAVTALGHANPKVAEILHHQANKLVHSSNLYFTKECLDLSEKIVEKTKQFGGQHDASRVFLCNSGTEANEAALKFAKKHGIMKNPSKQGIVAFENSFHGRTMGALSVTWNSKYRTPFGDLVPHVSFLNLNDEMTKLQSYIETKKDEIAGLIVEPIQGEGGVFPVEVEKLTGLKKICQDNDVIVIHDEIQCGLGRSGKLWAHAYLPSEAHPDIFTSAKALGNGFPIAATIVNEKVNNALRVGDHGTTYGGNPLACSVSNYVLDTIADEAFLKQVSKKSDILQKRLREIQAKYPNQIKTIRGKGLMLGAEFVEPPTEVIKKARELGLLIITAGKSTVRFVPALTIEDELIEEGMDAFEKAIEAVYA"},{"created_at":"2011-05-24T20:44:57.000Z","updated_at":"2011-05-27T14:56:01.000Z","name":"Arginine biosynthesis bifunctional protein ArgJ, mitochondrial","uniprot_id":"Q04728","uniprot_name":"ARGJ_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG7","num_residues":441,"molecular_weight":"47848.30078","theoretical_pi":"7.18","general_function":"Involved in glutamate N-acetyltransferase activity","specific_function":"Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate","reactions":[{"id":1755,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1806,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2339,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"N(2)-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2340,"direction":"\u003e","locations":"Mitochondrion matrix;Mitochondrion","altext":"Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"U90438","genbank_protein_id":"1895091","gene_card_id":"ARG7","chromosome_location":"chromosome 13","locus":"YMR062C","synonyms":["Extracellular mutant protein 40","Glutamate N-acetyltransferase","GAT","Ornithine acetyltransferase","OATase","Ornithine transacetylase","Amino-acid acetyltransferase","N-acetylglutamate synthase","AGS","Arginine biosynthesis bifunctional protein ArgJ alpha chain","Arginine biosynthesis bifunctional protein ArgJ beta chain"],"enzyme_classes":["2.3.1.35","2.3.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" acetyl-CoA:L-glutamate N-acetyltransferase activity"},{"category":"Function","description":" acetyltransferase activity"},{"category":"Function","description":" N-acetyltransferase activity"},{"category":"Function","description":" glutamate N-acetyltransferase activity"},{"category":"Process","description":" arginine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine metabolic process"}],"pfams":[{"name":"ArgJ","identifier":"PF01960"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGAGAATATCATCAACATTGCTTCAACGCTCGAAGCAGCTTATAGATAAGTATGCATTATACGTGCCCAAGACGGGCTCTTTTCCTAAAGGATTTGAAGTAGGCTACACTGCATCTGGAGTCAAAAAAAACGGGAGCCTGGACCTGGGTGTAATCTTGAATACCAATAAATCTCGTCCTTCAACCGCAGCAGCTGTTTTCACGACCAATAAATTCAAAGCTGCGCCAGTTTTGACATCGAAAAAAGTCCTTGAAACTGCTCGTGGTAAAAACATCAACGCTATTGTAGTCAATTCCGGTTGTGCTAACTCGGTCACAGGTGATCTTGGTATGAAAGATGCCCAAGTAATGATTGATTTGGTTAACGATAAAATTGGTCAAAAAAATTCTACCCTAGTCATGTCTACAGGCGTTATTGGACAACGACTACAGATGGACAAGATCAGCACTGGTATCAATAAAATTTTTGGAGAAGAAAAGTTCGGCAGTGATTTTAACTCTTGGTTGAACGTAGCCAAATCAATCTGTACTACTGATACTTTCCCAAAATTAGTTACATCTAGATTCAAATTACCTAGTGGTACTGAGTATACTTTGACAGGTATGGCAAAGGGCGCGGGTATGATTTGTCCGAATATGGCTACCTTATTAGGTTTCATAGTTACAGATCTTCCTATTGAAAGCAAGGCGTTGCAGAAGATGCTGACTTTCGCTACTACCCGTTCATTTAATTGTATATCGGTGGACGGTGATATGAGCACCAATGACACAATTTGCATGTTGGCCAACGGTGCTATTGACACCAAAGAAATTAACGAAGACTCTAAAGATTTTGAACAAGTAAAATTGCAGGTCACAGAATTTGCTCAGCGCTTGGCCCAGTTAGTCGTTCGCGATGGTGAAGGTTCGACAAAGTTTGTTACTGTTAACGTTAAAAATGCTTTGCATTTTGAAGACGCCAAAATAATTGCTGAATCAATCTCAAACTCTATGTTGGTCAAAACCGCACTATATGGGCAAGATGCCAATTGGGGAAGAATATTGTGCGCGATCGGGTATGCAAAGCTGAATGACTTAAAATCTCTAGATGTCAACAAAATTAATGTTAGCTTTATTGCTACCGACAATTCAGAACCTCGTGAGCTGAAGCTTGTCGCTAATGGTGTGCCACAATTGGAGATCGATGAAACAAGGGCTTCTGAAATATTGGCTTTGAATGATTTGGAAGTGTCTGTCGACTTGGGAACCGGTGATCAGGCAGCACAATTTTGGACTTGTGATTTATCACATGAATATGTAACAATTAACGGTGATTACCGTTCATAA","protein_sequence":"MRISSTLLQRSKQLIDKYALYVPKTGSFPKGFEVGYTASGVKKNGSLDLGVILNTNKSRPSTAAAVFTTNKFKAAPVLTSKKVLETARGKNINAIVVNSGCANSVTGDLGMKDAQVMIDLVNDKIGQKNSTLVMSTGVIGQRLQMDKISTGINKIFGEEKFGSDFNSWLNVAKSICTTDTFPKLVTSRFKLPSGTEYTLTGMAKGAGMICPNMATLLGFIVTDLPIESKALQKMLTFATTRSFNCISVDGDMSTNDTICMLANGAIDTKEINEDSKDFEQVKLQVTEFAQRLAQLVVRDGEGSTKFVTVNVKNALHFEDAKIIAESISNSMLVKTALYGQDANWGRILCAIGYAKLNDLKSLDVNKINVSFIATDNSEPRELKLVANGVPQLEIDETRASEILALNDLEVSVDLGTGDQAAQFWTCDLSHEYVTINGDYRS"},{"created_at":"2011-05-24T21:01:35.000Z","updated_at":"2011-07-22T17:53:43.000Z","name":"Branched-chain-amino-acid aminotransferase, cytosolic","uniprot_id":"P47176","uniprot_name":"BCA2_YEAST","enzyme":true,"transporter":false,"gene_name":"BAT2","num_residues":376,"molecular_weight":"41624.39844","theoretical_pi":"7.36","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Involved in cell cycle regulation","reactions":[{"id":1152,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1678,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1712,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2045,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2358,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2359,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":2360,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":14458,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006970","source":"Smpdb"},{"id":14459,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006974","source":"Smpdb"},{"id":14460,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006978","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z49648","genbank_protein_id":"1015897","gene_card_id":"BAT2","chromosome_location":"chromosome 10","locus":"YJR148W","synonyms":["BCAT","Protein TWT2"],"enzyme_classes":["2.6.1.42"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" branched-chain-amino-acid transaminase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" branched chain family amino acid metabolic process"}],"pfams":[{"name":"Aminotran_4","identifier":"PF01063"}],"pathways":[{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Leucine Degradation","kegg_map_id":null},{"name":"Valine Degradation","kegg_map_id":null}],"gene_sequence":"ATGACCTTGGCACCCCTAGACGCCTCCAAAGTTAAGATAACTACCACACAACATGCATCTAAGCCAAAACCGAACAGTGAGTTAGTGTTTGGCAAGAGCTTCACGGACCACATGTTAACTGCGGAATGGACAGCTGAAAAAGGGTGGGGTACCCCAGAGATTAAACCTTATCAAAATCTGTCTTTAGACCCTTCCGCGGTGGTTTTCCATTATGCTTTTGAGCTATTCGAAGGGATGAAGGCTTACAGAACGGTGGACAACAAAATTACAATGTTTCGTCCAGATATGAATATGAAGCGCATGAATAAGTCTGCTCAGAGAATCTGTTTGCCAACGTTCGACCCAGAAGAGTTGATTACCCTAATTGGGAAACTGATCCAGCAAGATAAGTGCTTAGTTCCTGAAGGAAAAGGTTACTCTTTATATATCAGGCCTACATTAATCGGCACTACGGCCGGTTTAGGGGTTTCCACGCCTGATAGAGCCTTGCTATATGTCATTTGCTGCCCTGTGGGTCCTTATTACAAAACTGGATTTAAGGCGGTCAGACTGGAAGCCACTGATTATGCCACAAGAGCTTGGCCAGGAGGCTGTGGTGACAAGAAACTAGGTGCAAACTACGCCCCCTGCGTCCTGCCACAATTGCAAGCTGCTTCAAGGGGTTACCAACAAAATTTATGGCTATTTGGTCCAAATAACAACATTACTGAAGTCGGCACCATGAATGCTTTTTTCGTGTTTAAAGATAGTAAAACGGGCAAGAAGGAACTAGTTACTGCTCCACTAGACGGTACCATTTTGGAAGGTGTTACTAGGGATTCCATTTTAAATCTTGCTAAAGAAAGACTCGAACCAAGTGAATGGACCATTAGTGAACGCTACTTCACTATAGGCGAAGTTACTGAGAGATCCAAGAACGGTGAACTACTTGAAGCCTTTGGTTCTGGTACTGCTGCGATTGTTTCTCCCATTAAGGAAATCGGCTGGAAAGGCGAACAAATTAATATTCCGTTGTTGCCCGGCGAACAAACCGGTCCATTGGCCAAAGAAGTTGCACAATGGATTAATGGAATCCAATATGGCGAGACTGAGCATGGCAATTGGTCAAGGGTTGTTACTGATTTGAACTGA","protein_sequence":"MTLAPLDASKVKITTTQHASKPKPNSELVFGKSFTDHMLTAEWTAEKGWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQDKCLVPEGKGYSLYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEATDYATRAWPGGCGDKKLGANYAPCVLPQLQAASRGYQQNLWLFGPNNNITEVGTMNAFFVFKDSKTGKKELVTAPLDGTILEGVTRDSILNLAKERLEPSEWTISERYFTIGEVTERSKNGELLEAFGSGTAAIVSPIKEIGWKGEQINIPLLPGEQTGPLAKEVAQWINGIQYGETEHGNWSRVVTDLN"},{"created_at":"2011-05-24T21:06:51.000Z","updated_at":"2011-07-22T17:53:43.000Z","name":"Branched-chain-amino-acid aminotransferase, mitochondrial","uniprot_id":"P38891","uniprot_name":"BCA1_YEAST","enzyme":true,"transporter":false,"gene_name":"BAT1","num_residues":393,"molecular_weight":"43595.69922","theoretical_pi":"9.27","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Appears to be involved in the regulation of the transition from G1 to S phase in the cell cycle. High copy suppressor of a temperature-sensitive mutation in the ABC transporter, ATM1","reactions":[{"id":1152,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1678,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1712,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2046,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2358,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2359,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":2360,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":14455,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006969","source":"Smpdb"},{"id":14456,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006973","source":"Smpdb"},{"id":14457,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006977","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY558111","genbank_protein_id":"45270112","gene_card_id":"BAT1","chromosome_location":"chromosome 8","locus":"YHR208W","synonyms":["BCAT","Protein ECA39","Protein TWT1"],"enzyme_classes":["2.6.1.42"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" branched-chain-amino-acid transaminase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" branched chain family amino acid metabolic process"}],"pfams":[{"name":"Aminotran_4","identifier":"PF01063"}],"pathways":[{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Leucine Degradation","kegg_map_id":null},{"name":"Valine Degradation","kegg_map_id":null}],"gene_sequence":"ATGTTGCAGAGACATTCCTTGAAGTTGGGGAAATTCTCCATCAGAACACTCGCTACTGGTGCCCCATTAGATGCATCCAAACTAAAAATTACTAGAAACCCAAATCCATCCAAGCCAAGACCAAATGAAGAATTAGTGTTCGGCCAGACATTCACCGATCATATGTTGACCATTCCTTGGTCAGCCAAAGAAGGGTGGGGCACTCCACACATCAAGCCTTACGGTAATCTTTCTCTTGACCCATCTGCTTGTGTATTCCATTATGCATTTGAATTATTTGAAGGTTTGAAAGCCTACAGAACTCCTCAAAATACTATCACCATGTTCCGTCCGGATAAGAACATGGCCCGTATGAACAAGTCTGCCGCTAGAATTTGTTTGCCAACTTTCGAATCTGAAGAATTGATCAAACTTACCGGGAAATTGATCGAACAAGATAAACACTTGGTTCCTCAAGGTAATGGTTACTCATTATACATCAGACCAACAATGATTGGTACATCCAAGGGTTTAGGTGTTGGCACTCCCTCCGAGGCTCTTCTTTATGTTATTACTTCTCCAGTCGGTCCTTATTATAAGACTGGTTTCAAAGCCGTACGTCTTGAAGCAACAGACTATGCTACAAGAGCTTGGCCAGGTGGTGTTGGCGACAAAAAATTGGGTGCTAACTATGCCCCATGCATCTTACCTCAACTACAAGCTGCCAAAAGAGGGTACCAACAAAATCTATGGTTGTTCGGCCCAGAAAAGAACATCACTGAGGTTGGTACTATGAACGTGTTCTTCGTTTTCCTCAACAAAGTCACTGGCAAGAAGGAATTGGTTACCGCTCCATTAGATGGTACCATTTTAGAAGGTGTTACCAGAGACTCTGTTTTAACATTGGCTCGTGACAAACTAGATCCTCAAGAATGGGACATCAACGAGCGTTATTACACTATTACTGAAGTCGCCACTAGAGCAAAACAAGGTGAACTATTAGAAGCCTTCGGTTCTGGTACTGCTGCTGTCGTTTCACCTATCAAGGAAATTGGCTGGAACAACGAAGATATTCATGTTCCACTATTGCCTGGTGAACAATGTGGTGCATTGACCAAGCAAGTTGCTCAATGGATTGCTGATATCCAATACGGTAGAGTCAATTATGGTAACTGGTCAAAAACTGTTGCCGACTTGAACTAA","protein_sequence":"MLQRHSLKLGKFSIRTLATGAPLDASKLKITRNPNPSKPRPNEELVFGQTFTDHMLTIPWSAKEGWGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYSLYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLEATDYATRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLWLFGPEKNITEVGTMNVFFVFLNKVTGKKELVTAPLDGTILEGVTRDSVLTLARDKLDPQEWDINERYYTITEVATRAKQGELLEAFGSGTAAVVSPIKEIGWNNEDIHVPLLPGEQCGALTKQVAQWIADIQYGRVNYGNWSKTVADLN"},{"created_at":"2011-05-26T16:22:54.000Z","updated_at":"2011-05-29T05:06:18.000Z","name":"Amino-acid acetyltransferase, mitochondrial","uniprot_id":"P40360","uniprot_name":"NAGS_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG2","num_residues":574,"molecular_weight":"65609.5","theoretical_pi":"9.26","general_function":"Involved in arginine biosynthetic process","specific_function":"N-acetylglutamate synthase involved in arginine biosynthesis","reactions":[{"id":1755,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2340,"direction":"\u003e","locations":"Mitochondrion matrix;Mitochondrion","altext":"Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"X88851","genbank_protein_id":"895896","gene_card_id":"ARG2","chromosome_location":"chromosome 10","locus":"YJL071W","synonyms":["Arginine-requiring protein 2","Glutamate N-acetyltransferase","N-acetylglutamate synthase","AGS","NAGS"],"enzyme_classes":["2.3.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine metabolic process"},{"category":"Process","description":" arginine biosynthetic process"}],"pfams":[{"name":"DUF619","identifier":"PF04768"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGTGGAGGAGAATATTCGCGCATGAACTCAAGTATGATCAACCCAATGCATCTTCAAAAAACTTGATCCTTTCAGTTCTGAATACAACCGCTACAAAACGAGAGGCTAAGGATTATCTCTCAAAATATACAAATGATAGTGGGCAGCATAATCATTGTTTGTTTTTTATCAGGGACCTGCATAAAGTCGCACCAGCGATTTTGTCCCAGTTTTCAAGTGTCATAAAGAGACTAGGAATGCTAGGTTTGCGACCTATGTTTGTAATTCCGCCGTCGCCAACTCATGTAAATATACAGGCAGAGTTACTTGACAGTATCGTTACAGAAGCAGATTTAAAGCCACTTCACCTTAAGGAGGGTCTTACTAAATCCCGCACTGGGTTATATCATTCTGTTTTTTCGCAAGAGAGTCGTTTCTTTGATATTGGAAATTCCAATTTTATACCAATTGTGAAACCTTATGTGTATAATGAAGAGACTGCTTCAGAATTCATGACAAAGGATGTTGTAAAATTTATGGATTGCCTGTGCCAAGGGAATATTCCACACATTGACAAATTCTTCATTCTAAATAATGCCGGAGGTATACCTTCGGGAGAGAGAAATGATAACGCTCATGTATTCATCAATCTTTCTCAGGAACTCGAGCATTTGTCCTCGTCATTATCTCACAATATAAGCACTCTAACCAAACGAGAGCCACGCTCCCAAAACCTGTTACACAGAATGGAGGTGTACGTTAAAAAAGATGAGATATCTTCCTTAGAATGTGAATACCATGATCATTTAGAAAACCTGTTATTGATGGACAAAGTTTTATCAAATCTAGCGGCTACAGCAACGGGACTGATTACAACTGTCAAAGCTGCCGCACTATCATCAGATAGGAAAAATCCTTTAGTATATAATTTATTGACAGACCGATCGCTAATTTCTTCTTCTTTACCAAGGTTTAAAAAAAAGGACGGCGAGATAGACTCACCAGCCAACATGTTTGATGATCACGCATGGTATGAATTGCCTTCCCAACAGGTAAATGCAGCTCCTTCTAACTCAGATGCAGTTTTAGTGACAACTGTTCTCAAAAAGGGCGTCCATATCAAAACTTATGACTATAAGACGCTGACTCAATTCAACTCAATTGGGCTTCCAAAGAAGTTTCACGTACCTGAGAAAGGAGCAAAACCCTCGAGCAATAGTCCAAAACTAGATATCAACAAATTTAAATCCATCATCGATCAGAGCTTTAAAAGATCTTTGGATTTGCATGACTACATAAAAAGGATTAATGGAAAAATAGCTACAATTATTGTGATAGGTGATTATGAAGGCATTGCAATTCTTACCTATGAAGGCTCGGAGGAAAATTCCTTTGTTTATCTCGATAAGTTCGCCGTTCTACCACACTTGAAAGGCTCGCTGGGTATATCTGATATAATCTTCAATTTGATGTTCAAAAAATTTCCTAATGAGATACTTTGGAGAAGCAGAAAAGACAATGTGGTGAACAAGTGGTATTTTCAACGTAGCGTTGCTGTGCTAGATTTGTCGATTGACTTAGACCCCGAACACTGTGATGAAAAGCAAAGCCAATTTAAACTATTTTACTACGGTAACCCTCAATACGCTAAGAGGGCACTACGTGACAAGAAACGTTTAAGAGAATTCATGAGGTCTGTCAGGGACATCAAGCCAAGTTGGGAAAATGAAAAAAATATTTCATGA","protein_sequence":"MWRRIFAHELKYDQPNASSKNLILSVLNTTATKREAKDYLSKYTNDSGQHNHCLFFIRDLHKVAPAILSQFSSVIKRLGMLGLRPMFVIPPSPTHVNIQAELLDSIVTEADLKPLHLKEGLTKSRTGLYHSVFSQESRFFDIGNSNFIPIVKPYVYNEETASEFMTKDVVKFMDCLCQGNIPHIDKFFILNNAGGIPSGERNDNAHVFINLSQELEHLSSSLSHNISTLTKREPRSQNLLHRMEVYVKKDEISSLECEYHDHLENLLLMDKVLSNLAATATGLITTVKAAALSSDRKNPLVYNLLTDRSLISSSLPRFKKKDGEIDSPANMFDDHAWYELPSQQVNAAPSNSDAVLVTTVLKKGVHIKTYDYKTLTQFNSIGLPKKFHVPEKGAKPSSNSPKLDINKFKSIIDQSFKRSLDLHDYIKRINGKIATIIVIGDYEGIAILTYEGSEENSFVYLDKFAVLPHLKGSLGISDIIFNLMFKKFPNEILWRSRKDNVVNKWYFQRSVAVLDLSIDLDPEHCDEKQSQFKLFYYGNPQYAKRALRDKKRLREFMRSVRDIKPSWENEKNIS"},{"created_at":"2011-05-26T16:32:02.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Glutamate--cysteine ligase","uniprot_id":"P32477","uniprot_name":"GSH1_YEAST","enzyme":true,"transporter":false,"gene_name":"GSH1","num_residues":678,"molecular_weight":"78252.89844","theoretical_pi":"6.22","general_function":"Involved in glutamate-cysteine ligase activity","specific_function":"ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine","reactions":[{"id":1560,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2425,"direction":"\u003e","locations":null,"altext":"ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.","export":false,"pw_reaction_id":null,"source":null},{"id":3829,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006346","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D90220","genbank_protein_id":"218429","gene_card_id":"GSH1","chromosome_location":"chromosome 10","locus":"YJL101C","synonyms":["Gamma-ECS","GCS","Gamma-glutamylcysteine synthetase"],"enzyme_classes":["6.3.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" glutamate-cysteine ligase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" peptide metabolic process"},{"category":"Process","description":" glutathione metabolic process"},{"category":"Process","description":" glutathione biosynthetic process"}],"pfams":[{"name":"GCS","identifier":"PF03074"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGGGACTCTTAGCTTTGGGCACGCCTTTGCAGTGGTTTGAGTCTAGGACGTACAATGAACACATAAGGGATGAAGGTATCGAGCAGTTGTTGTATATTTTCCAAGCTGCTGGTAAAAGAGACAATGACCCTCTTTTTTGGGGAGACGAGCTTGAGTACATGGTTGTAGATTTTGATGATAAGGAGAGAAATTCTATGCTCGACGTTTGCCATGACAAGATACTCACTGAGCTTAATATGGAGGATTCGTCCCTTTGTGAGGCTAACGATGTGAGTTTTCACCCTGAGTATGGCCGGTATATGTTAGAGGCAACACCAGCTTCTCCATATTTGAATTACGTGGGTAGTTACGTTGAGGTTAACATGCAAAAAAGACGTGCCATTGCAGAATATAAGCTATCTGAATATGCGAGACAAGATAGTAAAAATAACTTGCATGTGGGCTCCAGGTCTGTCCCTTTGACGCTGACTGTCTTCCCGAGGATGGGATGCCCCGACTTTATTAACATTAAGGATCCGTGGAATCATAAAAATGCCGCTTCCAGGTCTCTGTTTTTACCCGATGAAGTCATTAACAGACATGTCAGGTTTCCTAACTTGACAGCATCCATCAGGACCAGGCGTGGTGAAAAAGTTTGCATGAATGTTCCCATGTATAAAGATATAGCTACTCCAGAAACGGATGACTCCATCTACGATCGAGATTGGTTTTTACCAGAAGACAAAGAGGCGAAACTGGCTTCCAAACCGGGTTTCATTTATATGGATTCCATGGGTTTTGGCATGGGCTGTTCGTGCTTACAAGTGACCTTTCAGGCACCCAATATCAACAAGGCACGTTACCTGTACGATGCATTAGTGAATTTTGCACCTATAATGCTAGCCTTCTCTGCCGCTGCGCCTGCTTTTAAAGGTTGGCTAGCCGACCAAGATGTTCGTTGGAATGTGATATCTGGTGCGGTGGACGACCGTACTCCGAAGGAAAGAGGTGTTGCGCCATTACTACCCAAATACAACAAGAACGGATTTGGAGGCATTGCCAAAGACGTACAAGATAAAGTCCTTGAAATACCAAAGTCAAGATATAGTTCGGTTGATCTTTTCTTGGGTGGGTCGAAATTTTTCAATAGGACTTATAACGACACAAATGTACCTATTAATGAAAAAGTATTAGGACGACTACTAGAGAATGATAAGGCGCCACTGGACTATGATCTTGCTAAACATTTTGCGCATCTCTACATAAGAGATCCAGTATCTACATTCGAAGAACTGTTGAATCAGGACAACAAAACGTCTTCAAATCACTTTGAAAACATCCAAAGTACAAATTGGCAGACATTACGTTTTAAACCCCCCACACAACAAGCAACCCCGGACAAAAAGGATTCTCCTGGTTGGAGAGTGGAATTCAGACCATTTGAAGTGCAACTATTAGATTTTGAGAACGCTGCGTATTCCGTGCTCATATACTTGATTGTCGATAGCATTTTGACCTTTTCCGATAATATTAACGCATATATTCATATGTCCAAAGTATGGGAAAATATGAAGATAGCCCATCACAGAGATGCTATCCTATTTGAAAAATTTCATTGGAAAAAATCATTTCGCAACGACACCGATGTGGAAACTGAAGATTATTCTATAAGCGAGATTTTCCATAATCCAGAGAATGGTATATTTCCTCAATTTGTTACGCCAATCCTATGCCAAAAAGGGTTTGTAACCAAAGATTGGAAAGAATTAAAGCATTCTTCCAAACACGAGAGACTATACTATTATTTAAAGCTAATTTCTGATAGAGCAAGCGGTGAATTGCCAACAACAGCAAAATTCTTTAGAAATTTTGTACTACAACATCCAGATTACAAACATGATTCAAAAATTTCAAAGTCGATCAATTATGATTTGCTTTCTACGTGTGATAGACTTACCCATTTAGACGATTCAAAAGGTGAATTGACATCCTTTTTAGGAGCTGAAATTGCAGAATATGTAAAAAAAAATAAGCCTTCAATAGAAAGCAAATGTTAA","protein_sequence":"MGLLALGTPLQWFESRTYNEHIRDEGIEQLLYIFQAAGKRDNDPLFWGDELEYMVVDFDDKERNSMLDVCHDKILTELNMEDSSLCEANDVSFHPEYGRYMLEATPASPYLNYVGSYVEVNMQKRRAIAEYKLSEYARQDSKNNLHVGSRSVPLTLTVFPRMGCPDFINIKDPWNHKNAASRSLFLPDEVINRHVRFPNLTASIRTRRGEKVCMNVPMYKDIATPETDDSIYDRDWFLPEDKEAKLASKPGFIYMDSMGFGMGCSCLQVTFQAPNINKARYLYDALVNFAPIMLAFSAAAPAFKGWLADQDVRWNVISGAVDDRTPKERGVAPLLPKYNKNGFGGIAKDVQDKVLEIPKSRYSSVDLFLGGSKFFNRTYNDTNVPINEKVLGRLLENDKAPLDYDLAKHFAHLYIRDPVSTFEELLNQDNKTSSNHFENIQSTNWQTLRFKPPTQQATPDKKDSPGWRVEFRPFEVQLLDFENAAYSVLIYLIVDSILTFSDNINAYIHMSKVWENMKIAHHRDAILFEKFHWKKSFRNDTDVETEDYSISEIFHNPENGIFPQFVTPILCQKGFVTKDWKELKHSSKHERLYYYLKLISDRASGELPTTAKFFRNFVLQHPDYKHDSKISKSINYDLLSTCDRLTHLDDSKGELTSFLGAEIAEYVKKNKPSIESKC"},{"created_at":"2011-05-26T17:01:53.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Histidinol-phosphate aminotransferase","uniprot_id":"P07172","uniprot_name":"HIS8_YEAST","enzyme":true,"transporter":false,"gene_name":"HIS5","num_residues":385,"molecular_weight":"42645.69922","theoretical_pi":"6.37","general_function":"Involved in transferase activity","specific_function":"L-histidinol phosphate + 2-oxoglutarate = 3- (imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate","reactions":[{"id":1632,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2458,"direction":"\u003e","locations":null,"altext":"L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":4163,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006459","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z38125","genbank_protein_id":"558690","gene_card_id":"HIS5","chromosome_location":"chromosome 9","locus":"YIL116W","synonyms":["Imidazole acetol-phosphate transaminase"],"enzyme_classes":["2.6.1.9"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" histidinol-phosphate transaminase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" histidine family amino acid metabolic process"},{"category":"Process","description":" histidine metabolic process"},{"category":"Process","description":" histidine biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Histidine Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGGTTTTTGATTTGAAAAGAATTGTTAGACCAAAAATTTATAACTTGGAACCTTATCGCTGTGCAAGAGATGATTTCACCGAGGGTATATTGCTAGACGCCAATGAAAATGCCCATGGACCTACTCCAGTTGAATTGAGCAAGACCAATTTACATCGTTACCCGGATCCTCACCAATTGGAATTCAAGACCGCAATGACGAAATACAGGAACAAAACAAGCAGTTATGCCAATGACCCAGAGGTAAAACCTTTAACTGCTGACAATCTGTGCCTAGGTGTGGGATCTGATGAGAGTATTGATGCTATTATTAGAGCATGCTGTGTTCCCGGGAAAGAAAAGATTCTGGTTCTTCCACCAACATATTCTATGTACTCTGTTTGTGCAAACATTAATGATATAGAAGTCGTCCAATGTCCTTTAACTGTTTCCGACGGTTCTTTTCAAATGGATACCGAAGCTGTATTAACCATTTTGAAAAACGACTCGCTAATTAAGTTGATGTTCGTTACTTCACCAGGTAATCCAACCGGAGCCAAAATTAAGACCAGTTTAATCGAAAAGGTCTTACAGAATTGGGACAATGGGTTAGTCGTTGTTGATGAAGCTTACGTAGATTTTTGTGGTGGCTCTACAGCTCCACTAGTCACCAAGTATCCTAACTTGGTTACTTTGCAAACTCTATCCAAGTCATTCGGTTTAGCCGGGATTAGGTTGGGTATGACATATGCAACAGCAGAGTTGGCCAGAATTTTAAATGCAATGAAGGCGCCTTATAATATTTCCTCCCTAGCCTCTGAATATGCACTAAAAGCTGTTCAAGACAGTAATCTAAAGAAGATGGAAGCCACTTCGAAAATAATCAATGAAGAGAAAATGCGCCTCTTAAAGGAATTAACTGCTTTGGATTACGTTGATGACCAATATGTTGGTGGATTAGATGCTAATTTTCTTTTAATACGGATCAACGGGGGTGACAATGTCTTGGCAAAGAAGTTATATTACCAATTGGCTACTCAATCTGGGGTTGTCGTCAGATTTAGAGGTAACGAATTAGGCTGTTCCGGATGTTTGAGAATTACCGTTGGAACCCATGAGGAGAACACACATTTGATAAAGTACTTCAAGGAGACGTTATATAAGCTGGCCAATGAATAA","protein_sequence":"MVFDLKRIVRPKIYNLEPYRCARDDFTEGILLDANENAHGPTPVELSKTNLHRYPDPHQLEFKTAMTKYRNKTSSYANDPEVKPLTADNLCLGVGSDESIDAIIRACCVPGKEKILVLPPTYSMYSVCANINDIEVVQCPLTVSDGSFQMDTEAVLTILKNDSLIKLMFVTSPGNPTGAKIKTSLIEKVLQNWDNGLVVVDEAYVDFCGGSTAPLVTKYPNLVTLQTLSKSFGLAGIRLGMTYATAELARILNAMKAPYNISSLASEYALKAVQDSNLKKMEATSKIINEEKMRLLKELTALDYVDDQYVGGLDANFLLIRINGGDNVLAKKLYYQLATQSGVVVRFRGNELGCSGCLRITVGTHEENTHLIKYFKETLYKLANE"},{"created_at":"2011-05-26T17:20:37.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Phosphoserine aminotransferase","uniprot_id":"P33330","uniprot_name":"SERC_YEAST","enzyme":true,"transporter":false,"gene_name":"SER1","num_residues":395,"molecular_weight":"43415.19922","theoretical_pi":"6.52","general_function":"Involved in metabolic process","specific_function":"Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine","reactions":[{"id":1800,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1894,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2474,"direction":"\u003e","locations":null,"altext":"O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2475,"direction":"\u003e","locations":null,"altext":"4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3842,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006365","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"L20917","genbank_protein_id":"311153","gene_card_id":"SER1","chromosome_location":"chromosome 15","locus":"YOR184W","synonyms":["PSAT","Phosphohydroxythreonine aminotransferase"],"enzyme_classes":["2.6.1.52"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" L-serine metabolic process"},{"category":"Process","description":" L-serine biosynthetic process"}],"pfams":[{"name":"Aminotran_5","identifier":"PF00266"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTTTGGAAAGAGAGGAACCACAACATTTCGGAGCAGGGCCAGCTCAAATGCCTACACCAGTTTTGCAACAAGCTGCTAAAGACTTAATCAATTTCAATGACATAGGTTTGGGTATCGGTGAAATTTCTCACCGTTCGAAGGATGCCACCAAAGTGATTGAAGACTCTAAGAAGCACTTAATCGAACTGCTAAATATTCCTGACACTCATGAAGTGTTCTACTTGCAAGGTGGTGGCACTACTGGTTTTTCTTCCGTTGCTACTAATTTGGCAGCTGCATATGTGGGTAAGCATGGGAAGATTGCACCTGCCGGTTATTTAGTCACCGGTAGTTGGTCTCAGAAATCTTTTGAAGAGGCAAAGAGATTGCACGTTCCTGCTGAAGTTATCTTCAACGCTAAAGATTATAACAATGGCAAATTTGGTAAAATTCCGGATGAATCCCTTTGGGAAGATAAAATCAAAGGTAAGGCTTTCTCATACGTGTACCTATGTGAGAATGAAACTGTTCATGGTGTTGAATGGCCAGAATTACCAAAATGTTTAGTAAACGACCCCAACATCGAAATTGTTGCTGACTTATCCAGCGACATTTTGTCTCGTAAGATTGACGTTTCTCAATACGGTGTCATCATGGCAGGCGCCCAAAAAAACATTGGTTTAGCAGGCTTAACCCTATACATTATCAAGAAATCCATCCTTAAGAATATTTCTGGCGCTTCTGATGAAACATTACATGAATTGGGAGTACCAATCACCCCTATTGCATTCGACTATCCAACGGTGGTGAAGAACAACTCAGCCTATAATACAATTCCAATTTTCACTTTACATGTTATGGATCTCGTGTTCCAACATATTTTGAAGAAGGGTGGTGTTGAAGCGCAACAGGCTGAAAATGAAGAAAAGGCCAAGATATTATATGAGGCATTGGATGCAAATTCAGATTTTTACAACGTTCCAGTGGATCCAAAGTGTAGATCAAAAATGAATGTCGTTTTCACCCTTAAAAAGGACGGCCTTGATGACCAGTTTCTAAAAGAGGCAGCTGCTCGTCATTTAACCGGTTTGAAAGGACATCGTTCAGTTGGTGGGTTCAGAGCCTCCATCTATAACGCGCTTTCAGTGAAAGCTGTACAAAACTTGGTAGATTTTATCAAGGAATTTGCTGAGAAAAACGCTTAA","protein_sequence":"MSLEREEPQHFGAGPAQMPTPVLQQAAKDLINFNDIGLGIGEISHRSKDATKVIEDSKKHLIELLNIPDTHEVFYLQGGGTTGFSSVATNLAAAYVGKHGKIAPAGYLVTGSWSQKSFEEAKRLHVPAEVIFNAKDYNNGKFGKIPDESLWEDKIKGKAFSYVYLCENETVHGVEWPELPKCLVNDPNIEIVADLSSDILSRKIDVSQYGVIMAGAQKNIGLAGLTLYIIKKSILKNISGASDETLHELGVPITPIAFDYPTVVKNNSAYNTIPIFTLHVMDLVFQHILKKGGVEAQQAENEEKAKILYEALDANSDFYNVPVDPKCRSKMNVVFTLKKDGLDDQFLKEAAARHLTGLKGHRSVGGFRASIYNALSVKAVQNLVDFIKEFAEKNA"},{"created_at":"2011-05-26T17:45:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"General amino acid permease AGP1","uniprot_id":"P25376","uniprot_name":"AGP1_YEAST","enzyme":false,"transporter":true,"gene_name":"AGP1","num_residues":633,"molecular_weight":"69670.70313","theoretical_pi":"6.97","general_function":"Involved in transport","specific_function":"Broad substrate range permease which transports asparagine and glutamine with intermediate specificity. Also transports Ala, Cys, Gly, Ile, Leu, Met, Phe, Ser, Thr, Tyr and Val. Important for the utilization of amino acids as a nitrogen source","reactions":[],"signal_regions":"None","transmembrane_regions":"125-145;149-169;198-218;232-252;261-281;314-334;353-373;403-425;453-473;478-498;532-552;561-581","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"AGP1","chromosome_location":"chromosome 3","locus":"YCL025C","synonyms":["Asparagine/glutamine permease"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCGTCGTCGAAGTCTCTATACGAACTGAAAGACTTGAAAAATAGCTCCACAGAAATACATGCCACGGGGCAGGATAATGAAATTGAATATTTCGAAACAGGCTCCAATGACCGTCCATCCTCACAACCTCATTTAGGTTACGAACAGCATAACACTTCTGCCGTGCGTAGGTTTTTCGACTCCTTTAAAAGAGCGGATCAGGGTCCACAGGATGAAGTAGAAGCAACACAAATGAACGATCTTACGTCGGCTATCTCACCTTCTTCTAGACAGGCTCAAGAACTAGAAAAAAATGAAAGTTCGGACAACATAGGCGCTAATACAGGTCATAAGTCGGACTCGCTGAAGAAAACCATTCAGCCTAGACATGTTCTGATGATTGCGTTGGGTACGGGTATCGGTACTGGGTTATTGGTCGGTAACGGTACCGCGTTGGTTCATGCGGGTCCAGCTGGACTACTTATTGGTTACGCTATTATGGGTTCTATCTTGTACTGTATTATTCAAGCATGTGGTGAAATGGCGCTAGTGTATAGTAACTTGACTGGTGGCTACAATGCATACCCCAGTTTCCTTGTGGATGATGGTTTTGGGTTTGCAGTCGCTTGGGTTTATTGTTTGCAATGGCTGTGTGTGTGTCCTCTGGAATTGGTGACCGCATCCATGACTATCAAATATTGGACGACATCTGTGAACCCGGATGTGTTCGTCATTATTTTCTATGTTTTGGTGATTACTATTAATATTTTCGGTGCTCGTGGTTATGCAGAAGCTGAGTTCTTCTTCAACTGTTGCAAAATTTTGATGATGACTGGGTTCTTCATTCTTGGTATTATCATCGATGTTGGTGGCGCTGGTAATGATGGTTTTATTGGTGGTAAATACTGGCACGATCCGGGCGCTTTCAATGGTAAACATGCCATTGACAGATTTAAAGGTGTTGCTGCAACATTAGTGACTGCTGCTTTTGCCTTTGGTGGTTCAGAGTTTATTGCCATCACCACTGCAGAACAATCTAATCCAAGAAAGGCCATTCCAGGTGCGGCCAAACAAATGATCTACAGAATCTTATTCCTATTCTTGGCTACCATTATTCTACTGGGTTTCTTGGTGCCATACAATTCCGATCAATTATTGGGTTCTACCGGTGGTGGTACTAAAGCCTCGCCATATGTCATTGCTGTTGCATCCCACGGTGTCCGTGTCGTCCCACACTTCATTAACGCCGTTATTCTACTTTCCGTGCTGTCCATGGCTAACTCCTCCTTCTACTCCAGTGCTCGTTTATTTTTAACTCTATCCGAGCAAGGTTACGCTCCTAAGGTTTTCTCCTACATCGACAGAGCCGGTAGACCATTGATTGCCATGGGTGTTTCTGCATTGTTTGCCGTTATTGCCTTCTGTGCTGCATCTCCCAAGGAAGAACAAGTTTTCACTTGGTTATTGGCCATTTCTGGTTTGTCTCAGCTTTTCACATGGACTGCCATTTGTTTATCCCATCTTAGATTTAGAAGAGCCATGAAAGTCCAAGGGAGATCTCTTGGAGAATTGGGTTTCAAATCTCAAACTGGTGTTTGGGGATCTGCCTACGCTTGCATTATGATGATTTTAATTCTTATTGCCCAATTTTGGGTCGCTATCGCCCCCATTGGTGAAGGTAAGCTGGATGCACAAGCCTTTTTCGAAAACTACTTGGCTATGCCAATCTTGATTGCACTTTATGTCGGCTACAAGGTCTGGCACAAGGATTGGAAACTGTTCATCAGGGCAGACAAGATCGACCTAGATTCTCATAGACAAATCTTTGATGAAGAATTAATCAAGCAAGAAGACGAAGAATATAGGGAACGTTTGAGGAACGGACCTTATTGGAAAAGGGTCGTTGCCTTCTGGTGTTAA","protein_sequence":"MSSSKSLYELKDLKNSSTEIHATGQDNEIEYFETGSNDRPSSQPHLGYEQHNTSAVRRFFDSFKRADQGPQDEVEATQMNDLTSAISPSSRQAQELEKNESSDNIGANTGHKSDSLKKTIQPRHVLMIALGTGIGTGLLVGNGTALVHAGPAGLLIGYAIMGSILYCIIQACGEMALVYSNLTGGYNAYPSFLVDDGFGFAVAWVYCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVIIFYVLVITINIFGARGYAEAEFFFNCCKILMMTGFFILGIIIDVGGAGNDGFIGGKYWHDPGAFNGKHAIDRFKGVAATLVTAAFAFGGSEFIAITTAEQSNPRKAIPGAAKQMIYRILFLFLATIILLGFLVPYNSDQLLGSTGGGTKASPYVIAVASHGVRVVPHFINAVILLSVLSMANSSFYSSARLFLTLSEQGYAPKVFSYIDRAGRPLIAMGVSALFAVIAFCAASPKEEQVFTWLLAISGLSQLFTWTAICLSHLRFRRAMKVQGRSLGELGFKSQTGVWGSAYACIMMILILIAQFWVAIAPIGEGKLDAQAFFENYLAMPILIALYVGYKVWHKDWKLFIRADKIDLDSHRQIFDEELIKQEDEEYRERLRNGPYWKRVVAFWC"},{"created_at":"2011-05-26T17:50:01.000Z","updated_at":"2011-07-22T17:54:37.000Z","name":"Folylpolyglutamate synthase 1","uniprot_id":"Q12676","uniprot_name":"FOLD_YEAST","enzyme":true,"transporter":false,"gene_name":"FOL3","num_residues":427,"molecular_weight":"47850.80078","theoretical_pi":"6.82","general_function":"Involved in tetrahydrofolylpolyglutamate synthase activity","specific_function":"Conversion of folates to polyglutamate derivatives","reactions":[{"id":1456,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2486,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion. Cytoplasm;Mitochondrion","altext":"ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).","export":false,"pw_reaction_id":null,"source":null},{"id":4146,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006447","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z49702","genbank_protein_id":"817872","gene_card_id":"FOL3","chromosome_location":"chromosome 13","locus":"YMR113W","synonyms":["Folylpoly-gamma-glutamate synthetase","FPGS","Tetrahydrofolylpolyglutamate synthase","Tetrahydrofolate synthase"],"enzyme_classes":["6.3.2.17"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" tetrahydrofolylpolyglutamate synthase activity"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"}],"pfams":[{"name":"Mur_ligase_M","identifier":"PF08245"}],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGGCCATTGAATTGGGACTTTCCCGTATTACAAAACTACTAGAGCATTTAGGCAATCCGCAAAACTCACTTAGAGTGCTGCACATTGCAGGGACAAATGGTAAAGGTTCAGTATGTACTTACCTATCTTCTGTGTTGCAACAAAAGTCCTACCAAATTGGAAAATTTACCACTCCACACTTGGTGCATGTTACTGATTCCATTACAATCAACAATAAGCCGATTCCGTTAGAGAGATACCAGAATATTAGATTACAACTAGAAGCTTTAAACAAGTCACACTCTTTAAAATGTACGGAATTCGAGCTATTAACATGTACCGCATTCAAATATTTTTATGATGTGCAGTGCCAATGGTGTGTCATAGAAGTAGGCCTTGGCGGAAGACTTGATGCGACCAATGTTATTCCAGGCGCAAATAAGGCATGTTGTGGTATTACTAAAATCAGTTTGGATCATGAAAGCTTTTTAGGTAACACCTTGTCTGAAATCTCTAAAGAGAAAGCAGGTATAATAACAGAAGGGGTACCCTTCACAGTGATTGATGGAACCAATGAGGCAAGTGTTATAAATGTTGTGAAAGAAAGATGCAAGGCTTTAGGGTCTGAACTATCCGTTACAGATTCTCAACTTAACGGAAATATGATTGACACCAACTCCTGGGGTTGTTTTGACTTGGCAAAATTGCCACTGAATGGAGAATATCAGATATTTAATCTCAGGGTGGCCATGGGTATGTTAGACTACTTACAAATGAACGAACTTATTGATATTACCAAGAATGAAGTAAGTACGAGATTGGCGAAGGTTGATTGGCCAGGAAGGTTATATCGTATGGATTATCGCTTTGACAAAGTAAGTAATAGGACAGTGCCTATATTAATGGACGGTGCCCACAATGGCTCAGCTGCAGTAGAGTTAGTTAAGTACCTAAGAAAGGAGTACGGAAACCAGCCTTTGACCTTTGTGATGGCAGTAACGCATGGGAAAAACTTGGAGCCGCTGCTCCAGCCATTATTGAGGCCTATAGATCAAGTAATTCTTACTCGGTTTAATAATGTGGAAGGTATGCCCTGGATTCATGCCACTGATCCTGAAGAAATAAAAGATTTTATTTTGACTCAAGGATACACAAAGGAGATAGTGATTGAAAATGATTTACATCAGGTATTGCCTTCTCTGGCGCATGTATCAGACGAGCAAAGACGGCCAATTGTTGTATGCGGTTCACTGTATTTATGTGGTGAATTATTACGGATTCACAATAGTCACTTGAGAAACTAA","protein_sequence":"MAIELGLSRITKLLEHLGNPQNSLRVLHIAGTNGKGSVCTYLSSVLQQKSYQIGKFTTPHLVHVTDSITINNKPIPLERYQNIRLQLEALNKSHSLKCTEFELLTCTAFKYFYDVQCQWCVIEVGLGGRLDATNVIPGANKACCGITKISLDHESFLGNTLSEISKEKAGIITEGVPFTVIDGTNEASVINVVKERCKALGSELSVTDSQLNGNMIDTNSWGCFDLAKLPLNGEYQIFNLRVAMGMLDYLQMNELIDITKNEVSTRLAKVDWPGRLYRMDYRFDKVSNRTVPILMDGAHNGSAAVELVKYLRKEYGNQPLTFVMAVTHGKNLEPLLQPLLRPIDQVILTRFNNVEGMPWIHATDPEEIKDFILTQGYTKEIVIENDLHQVLPSLAHVSDEQRRPIVVCGSLYLCGELLRIHNSHLRN"},{"created_at":"2011-05-26T18:10:06.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"NAD-specific glutamate dehydrogenase","uniprot_id":"P33327","uniprot_name":"DHE2_YEAST","enzyme":true,"transporter":false,"gene_name":"GDH2","num_residues":1092,"molecular_weight":"124331.0","theoretical_pi":"5.46","general_function":"Involved in oxidoreductase activity","specific_function":"L-glutamate + H(2)O + NAD(+) = 2-oxoglutarate + NH(3) + NADH","reactions":[{"id":1572,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2512,"direction":"\u003e","locations":null,"altext":"L-glutamate + H(2)O + NAD(+) = 2-oxoglutarate + NH(3) + 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donors"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" glutamate dehydrogenase activity"},{"category":"Process","description":" 2-oxoglutarate metabolic process"},{"category":"Process","description":" glutamate catabolic process to 2-oxoglutarate"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" dicarboxylic acid metabolic process"}],"pfams":[{"name":"Bac_GDH","identifier":"PF05088"},{"name":"ELFV_dehydrog","identifier":"PF00208"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"gene_sequence":"ATGCTTTTTGATAACAAAAATCGCGGTGCTTTAAACTCACTGAACACACCAGATATTGCTTCTTTATCAATATCATCCATGTCGGACTATCACGTGTTTGATTTTCCCGGTAAGGACCTGCAGAGAGAGGAAGTGATAGATTTGCTAGATCAGCAAGGGTTTATTCCCGACGATTTGATCGAACAAGAAGTAGATTGGTTTTATAACTCATTGGGTATTGACGATTTGTTCTTCTCGAGAGAATCTCCCCAATTAATCTCGAATATCATACATTCTTTGTATGCTTCAAAGCTAGATTTCTTTGCGAAGTCCAAATTCAACGGAATTCAGCCAAGGCTATTCAGCATTAAAAACAAAATTATAACTAATGATAATCATGCCATCTTTATGGAATCTAATACTGGTGTCAGCATAAGCGATTCTCAGCAAAAAAACTTTAAATTTGCTAGTGACGCCGTCGGAAACGATACTTTGGAGCATGGTAAGGATACCATCAAAAAAAATAGGATTGAAATGGATGATTCTTGTCCACCTTATGAATTAGATTCCGAAATTGATGACCTTTTCCTGGATAACAAGTCTCAAAAAAACTGCAGATTAGTTTCTTTTTGGGCTCCAGAAAGCGAATTAAAGCTAACTTTTGTTTATGAGAGTGTTTACCCTAATGATGATCCAGCCGGCGTAGATATTTCCTCTCAGGATTTGCTGAAAGGTGATATTGAATCGATTAGTGATAAGACCATGTACAAAGTTTCGTCGAACGAAAATAAAAAACTATACGGTCTCTTACTTAAGTTGGTTAAAGAAAGAGAAGGTCCTGTCATTAAGACTACTCGCTCCGTAGAAAATAAGGATGAAATTAGGTTATTAGTCGCTTACAAGCGATTCACCACTAAGCGTTATTACTCTGCTTTGAACTCTTTGTTCCACTATTACAAGTTGAAACCTTCTAAGTTCTATTTAGAGTCGTTTAATGTTAAGGATGATGACATCATTATCTTTTCCGTTTATTTGAACGAGAACCAGCAATTGGAAGATGTTCTACTTCACGATGTGGAGGCAGCATTGAAACAGGTTGAAAGAGAAGCTTCATTGCTATACGCTATCCCAAACAATTCTTTCCATGAGGTTTACCAGAGACGTCAATTCTCGCCCAAAGAAGCTATATATGCTCATATTGGTGCTATATTCATTAACCATTTTGTTAATCGTTTAGGCTCTGATTATCAAAACCTTTTATCTCAAATCACCATTAAGCGTAATGATACTACTCTTTTGGAGATTGTAGAAAACCTAAAAAGAAAGTTAAGAAATGAAACCTTAACTCAGCAAACTATTATCAACATCATGTCGAAGCATTACACTATAATTTCCAAGTTGTATAAAAATTTTGCTCAAATTCACTATTATCATAATAGTACTAAAGATATGGAGAAGACATTATCTTTTCAAAGACTGGAAAAAGTGGAGCCTTTTAAGAATGACCAAGAGTTCGAAGCTTACTTGAATAAATTCATTCCAAATGATTCACCTGATTTGTTGATCCTGAAAACACTGAACATCTTCAACAAGTCTATTTTGAAGACAAATTTCTTTATTACAAGAAAAGTAGCAATATCATTCAGATTAGATCCTTCCCTGGTGATGACAAAATTCGAATATCCAGAGACACCCTATGGTATATTTTTTGTCGTTGGTAATACTTTCAAAGGGTTCCATATCAGGTTCAGAGATATCGCAAGGGGCGGTATTCGTATAGTCTGTTCCAGGAATCAGGATATTTATGATTTGAATTCCAAGAACGTTATTGATGAGAACTATCAATTGGCCTCTACTCAGCAACGTAAAAATAAGGATATTCCAGAGGGTGGCTCTAAAGGTGTCATCTTATTGAACCCAGGATTGGTAGAACATGACCAGACATTTGTCGCCTTTTCCCAATATGTGGATGCAATGATTGACATTCTAATCAACGATCCATTAAAGGAAAACTATGTCAACCTTTTACCAAAGGAGGAAATATTATTTTTTGGCCCAGATGAAGGAACTGCTGGTTTCGTGGATTGGGCAACTAACCATGCTCGTGTGAGGAACTGCCCATGGTGGAAATCATTTTTGACTGGAAAATCCCCATCTTTGGGTGGTATTCCCCATGACGAATATGGTATGACTTCTCTGGGTGTTCGTGCTTATGTTAATAAAATTTACGAAACTTTAAACTTGACAAATTCTACTGTTTACAAATTCCAAACTGGTGGTCCGGATGGTGATTTGGGATCCAATGAAATTCTTTTATCTTCGCCAAACGAATGTTATTTGGCAATTCTGGACGGTTCAGGTGTCCTGTGTGATCCTAAAGGTTTAGATAAAGATGAATTATGCCGCTTGGCACATGAAAGGAAAATGATTTCCGATTTCGACACTTCCAAATTATCAAACAACGGATTTTTTGTTTCTGTGGATGCAATGGATATCATGCTACCAAATGGTACAATTGTAGCTAACGGCACAACCTTCAGAAACACCTTTCATACTCAAATTTTCAAATTTGTGGATCATGTCGACATTTTTGTTCCATGCGGTGGTAGACCAAACTCAATTACTCTAAATAATCTACATTATTTTGTTGACGAAAAGACTGGGAAATGTAAAATTCCATATATTGTGGAGGGTGCCAATCTATTTATAACGCAACCTGCTAAAAATGCTTTGGAGGAACATGGCTGTATTCTGTTCAAAGATGCTTCTGCAAACAAAGGTGGTGTCACATCTTCATCAATGGAAGTGTTGGCCTCACTAGCGCTTAACGATAACGACTTCGTGCACAAATTTATTGGAGATGTTAGTGGTGAGAGGTCTGCGTTGTACAAGTCGTACGTTGTAGAAGTGCAGTCAAGAATTCAGAAAAATGCTGAATTAGAGTTTGGTCAGTTATGGAATTTGAATCAACTAAATGGAACCCACATTTCAGAAATTTCAAACCAATTGTCCTTCACTATAAACAAATTGAACGACGATCTAGTTGCTTCTCAAGAGTTGTGGCTCAATGATCTAAAATTAAGAAACTACCTATTGTTGGATAAAATAATTCCAAAAATTCTGATTGATGTTGCTGGGCCTCAGTCCGTATTGGAAAACATTCCAGAGAGCTATTTGAAAGTTCTTCTGTCGAGTTACTTATCAAGCACTTTTGTTTACCAGAACGGTATCGATGTTAACATTGGAAAATTCTTGGAATTTATTGGTGGGTTAAAAAGAGAAGCGGAGGCAAGTGCTTGA","protein_sequence":"MLFDNKNRGALNSLNTPDIASLSISSMSDYHVFDFPGKDLQREEVIDLLDQQGFIPDDLIEQEVDWFYNSLGIDDLFFSRESPQLISNIIHSLYASKLDFFAKSKFNGIQPRLFSIKNKIITNDNHAIFMESNTGVSISDSQQKNFKFASDAVGNDTLEHGKDTIKKNRIEMDDSCPPYELDSEIDDLFLDNKSQKNCRLVSFWAPESELKLTFVYESVYPNDDPAGVDISSQDLLKGDIESISDKTMYKVSSNENKKLYGLLLKLVKEREGPVIKTTRSVENKDEIRLLVAYKRFTTKRYYSALNSLFHYYKLKPSKFYLESFNVKDDDIIIFSVYLNENQQLEDVLLHDVEAALKQVEREASLLYAIPNNSFHEVYQRRQFSPKEAIYAHIGAIFINHFVNRLGSDYQNLLSQITIKRNDTTLLEIVENLKRKLRNETLTQQTIINIMSKHYTIISKLYKNFAQIHYYHNSTKDMEKTLSFQRLEKVEPFKNDQEFEAYLNKFIPNDSPDLLILKTLNIFNKSILKTNFFITRKVAISFRLDPSLVMTKFEYPETPYGIFFVVGNTFKGFHIRFRDIARGGIRIVCSRNQDIYDLNSKNVIDENYQLASTQQRKNKDIPEGGSKGVILLNPGLVEHDQTFVAFSQYVDAMIDILINDPLKENYVNLLPKEEILFFGPDEGTAGFVDWATNHARVRNCPWWKSFLTGKSPSLGGIPHDEYGMTSLGVRAYVNKIYETLNLTNSTVYKFQTGGPDGDLGSNEILLSSPNECYLAILDGSGVLCDPKGLDKDELCRLAHERKMISDFDTSKLSNNGFFVSVDAMDIMLPNGTIVANGTTFRNTFHTQIFKFVDHVDIFVPCGGRPNSITLNNLHYFVDEKTGKCKIPYIVEGANLFITQPAKNALEEHGCILFKDASANKGGVTSSSMEVLASLALNDNDFVHKFIGDVSGERSALYKSYVVEVQSRIQKNAELEFGQLWNLNQLNGTHISEISNQLSFTINKLNDDLVASQELWLNDLKLRNYLLLDKIIPKILIDVAGPQSVLENIPESYLKVLLSSYLSSTFVYQNGIDVNIGKFLEFIGGLKREAEASA"},{"created_at":"2011-05-26T18:11:13.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"NADP-specific glutamate dehydrogenase 2","uniprot_id":"P39708","uniprot_name":"DHE5_YEAST","enzyme":true,"transporter":false,"gene_name":"GDH3","num_residues":457,"molecular_weight":"49626.80078","theoretical_pi":"5.12","general_function":"Involved in oxidoreductase activity","specific_function":"L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH","reactions":[{"id":1573,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2514,"direction":"\u003e","locations":"","altext":"L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":3745,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006272","source":"Smpdb"},{"id":14890,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007081","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U12980","genbank_protein_id":"595524","gene_card_id":"GDH3","chromosome_location":"chromosome 1","locus":"YAL062W","synonyms":["NADP-GDH 2","NADP-dependent glutamate dehydrogenase 2"],"enzyme_classes":["1.4.1.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH2 group of donors"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"ELFV_dehydrog","identifier":"PF00208"},{"name":"ELFV_dehydrog_N","identifier":"PF02812"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"gene_sequence":"ATGACAAGCGAACCAGAGTTTCAGCAGGCTTACGATGAGATCGTTTCTTCTGTGGAGGATTCCAAAATTTTTGAAAAATTCCCACAGTATAAAAAAGTGTTACCTATTGTTTCTGTCCCGGAGAGGATCATTCAATTCAGGGTCACGTGGGAAAATGATAATGGCGAGCAAGAAGTGGCTCAAGGATACAGGGTGCAGTTCAATTCAGCCAAGGGCCCTTACAAGGGTGGCCTACGCTTCCACCCATCAGTGAACCTGTCTATCCTAAAATTTTTGGGTTTTGAACAGATCTTCAAGAATGCGCTCACTGGGCTAGATATGGGCGGTGGTAAGGGTGGCCTGTGTGTGGACTTGAAAGGCAAGTCTGACAACGAGATCAGAAGGATTTGTTATGCGTTCATGAGAGAACTGAGCAGGCATATTGGTAAGGACACAGACGTGCCCGCAGGAGATATTGGTGTCGGTGGCCGTGAAATTGGCTACCTATTCGGCGCTTACAGATCATACAAGAACTCCTGGGAAGGTGTGTTGACTGGTAAGGGTTTAAACTGGGGTGGCTCACTTATCAGGCCGGAGGCCACCGGGTTCGGCTTAGTTTACTATACGCAAGCAATGATCGATTATGCAACAAACGGCAAGGAGTCGTTTGAGGGCAAACGTGTGACAATCTCCGGAAGTGGCAATGTTGCGCAATATGCAGCTTTGAAAGTGATCGAGCTGGGTGGTATTGTGGTGTCTTTATCCGATTCGAAGGGGTGCATCATCTCTGAGACGGGCATTACTTCTGAGCAAATTCACGATATCGCTTCCGCCAAGATCCGTTTCAAGTCGTTAGAGGAAATCGTTGATGAATACTCTACTTTCAGCGAAAGTAAGATGAAGTACGTTGCAGGAGCACGCCCATGGACGCATGTGAGCAACGTCGACATTGCCTTGCCCTGTGCCACCCAAAACGAGGTCAGTGGTGACGAAGCCAAGGCCCTAGTGGCATCTGGCGTTAAGTTCGTTGCCGAAGGTGCTAACATGGGTTCTACACCCGAGGCTATTTCTGTTTTCGAAACAGCGCGTAGCACTGCAACCAATGCAAAGGATGCAGTTTGGTTTGGGCCACCAAAGGCAGCTAACCTGGGCGGCGTGGCAGTATCCGGTCTGGAAATGGCTCAGAATTCTCAAAAAGTAACTTGGACTGCCGAGCGGGTCGATCAAGAACTAAAGAAGATAATGATCAACTGCTTCAACGACTGCATACAGGCCGCACAAGAGTACTCTACGGAAAAAAATACAAACACCTTGCCATCATTGGTCAAGGGGGCCAACATTGCCAGCTTCGTCATGGTGGCTGACGCAATGCTTGACCAGGGAGACGTTTTTTAG","protein_sequence":"MTSEPEFQQAYDEIVSSVEDSKIFEKFPQYKKVLPIVSVPERIIQFRVTWENDNGEQEVAQGYRVQFNSAKGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLDMGGGKGGLCVDLKGKSDNEIRRICYAFMRELSRHIGKDTDVPAGDIGVGGREIGYLFGAYRSYKNSWEGVLTGKGLNWGGSLIRPEATGFGLVYYTQAMIDYATNGKESFEGKRVTISGSGNVAQYAALKVIELGGIVVSLSDSKGCIISETGITSEQIHDIASAKIRFKSLEEIVDEYSTFSESKMKYVAGARPWTHVSNVDIALPCATQNEVSGDEAKALVASGVKFVAEGANMGSTPEAISVFETARSTATNAKDAVWFGPPKAANLGGVAVSGLEMAQNSQKVTWTAERVDQELKKIMINCFNDCIQAAQEYSTEKNTNTLPSLVKGANIASFVMVADAMLDQGDVF"},{"created_at":"2011-05-26T18:13:32.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"NADP-specific glutamate dehydrogenase 1","uniprot_id":"P07262","uniprot_name":"DHE4_YEAST","enzyme":true,"transporter":false,"gene_name":"GDH1","num_residues":454,"molecular_weight":"49569.60156","theoretical_pi":"5.39","general_function":"Involved in oxidoreductase activity","specific_function":"L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH","reactions":[{"id":1573,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2514,"direction":"\u003e","locations":"","altext":"L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":3744,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006271","source":"Smpdb"},{"id":14889,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007080","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M11297","genbank_protein_id":"171592","gene_card_id":"GDH1","chromosome_location":"chromosome 15","locus":"YOR375C","synonyms":["NADP-GDH 1","NADP-dependent glutamate dehydrogenase 1"],"enzyme_classes":["1.4.1.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH2 group of donors"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"ELFV_dehydrog","identifier":"PF00208"},{"name":"ELFV_dehydrog_N","identifier":"PF02812"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Glutamate 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adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular 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Available"}],"pfams":[{"name":"Hydant_A_N","identifier":"PF05378"},{"name":"Hydantoinase_A","identifier":"PF01968"},{"name":"Hydantoinase_B","identifier":"PF02538"}],"pathways":[],"gene_sequence":"ATGCAGAAAGGAAACATAAGAATTGCCATCGATAAGGGTGGAACTTTCACTGATTGTGTGGGGAATATTGGTACAGGTAAACAAGAACATGATACTGTCATCAAGCTCTTGTCGGTGGATCCCAAAAACTATCCAGATGCTCCCCTTGAAGGCATAAGACGTCTCTTGGAGGTGCTTGAACACAAGACAATTCCTCGCGGTATTCCTCTAGACATCTCTAATGTGAGAAGTTTAAGAATGGGGACAACCCTAGCTACAAACTGCGCTCTAGAAAGAAATGGTGAACGTTGTGCCTTCATTACTACGAAAGGCTTTAAGGATTCATTGCTGATTGGAGACCAAACCAGGCCAGATATCTTCAACTTAAATATAAAAAAGGTAGTGCCATTATATGACACTGTAGTTGAAATAGATGAGAGAGTTACTTTAGAAGATTTCTCGGAAGACCCTTATTTTACCAAATCGTCTCCTAATGAACAAGAAGGTATCCTGGAAGGTAATAGTGGCGAAATGGTAAGGGTCATAAAGAAGCCAGATGAATCAAGCGTAAGATCTATTCTGAAAGTGCTTTATGCTAGCGGAATCAAGTCTATTGCGATAGCATTTTTACACTCATACACTTTTCCAGACCATGAGCGAATTGTTGGTAATATTGCCAGGGAGATTGGGTTTTCTCATGTTTCATTATCATCTGAAGTCTCTCCAATGATAAAATTTTTACCGAGGGCTCACAGTTCTGTCGCAGATGCCTACCTTACTCCGGTAATTAAAAAGTACTTGAATAGCATTTCTGCAGGTTTGAGCCACGCAGAAGATACCCACATTCAATTCATGCAGTCTGATGGTGGTTTAGTGGATGGGGGAAAATTTTCCGGTTTGAAATCTATTTTATCTGGTCCTGCAGGTGGCGTAATAGGTTATTCTAGTACATGCTATGATAAAAATAATAACATACCCTTAATAGGCTTTGACATGGGAGGAACATCTACTGATGTCAGTAGGTACGGCGATGGGAGGTTAGAACATGTTTTTGAAACTGTTACCGCAGGGATCATCATACAATCTCCTCAACTTGACATCCATACTGTTGCTGCTGGAGGAAGTTCTATTTTGTCATGGAAAAACGGGTTATTCAGAGTAGGCCCTGATTCAGCAGCTGCTGATCCAGGCCCTGCAGCCTACAGAAAGGGCGGGCCTTTGACCATTACAGACGCCAACCTCTTTTTAGGACGTTTGGTTCCTGAGTTCTTCCCCAAAATTTTTGGGCCCAATGAGGATGAATCACTTGACTTAGAAACCACTACTTTGAAATTCAGAGAATTAACAGATGTCATCAATAAGGATCTGAATTCAAATCTAACCATGGAAGAGGTTGCCTATGGATTTATCAAAGTAGCTAACGAATGCATGGCAAGACCTGTGAGGGCCATTACAGAAGCAAAAGGACATGTAGTATCTCAGCATCGGTTAGTTTCCTTTGGCGGGGCTGGCGGGCAACACGCCATAGCGGTTGCAGATTCATTGGGCATTGACACTGTTTTAATTCATAGATATTCTTCTATCTTGTCCGCTTATGGCATTTTCTTAGCAGATGTTATTGAAGAAAACCAAGAGCCTTGCTCTTTTATCTTGGGTGAGCCAGAGACCATCTTGAAAGTGAAAAAAAGATTCTTAGAACTTTCTAAAAATTCAATCAAAAACCTTTTATCTCAGTCGTTTTCTCGGGAGGACATAGTCTTGGAAAGATATTTAAATCTCAGATATGAAGGTACTGAAACCAGTTTGATGATATTACAAAAATATGATGACCAATGGAATTTTAGGGAATGGTTCTCTGAAGCTCATAAAAAAGAGTTCGGATTCTCATTCGATGACAAACGAATTATAATTGATGATATAAGGATAAGAGCAATTGGGAAATCAGGCGTTAGAAAAGAAAAAACGGTTGATGAGCAATTGATTGAAATTTCCCATTTCAAGAAAGCCGACGTGTCAAAGGATGCTAGTTTTACCCAGAAAGCATATTTTGACAACAAATGGGTCGACACTGCGGTCTTCAAAATTGATGATCTTCCTGCCGGAACAATTATCGAGGGCCCAGCCATATTGGCTGACGGTACCCAAACAAATATTATTTTACCAAACAGCCAAGCAACAATTTTAAACTCTCATATATTTATCAAGATCAACCAAAAGGCTGCGAAGACATTATCTAAAAGCGGATATGAACTTGATATAGATCCAATCTTATTGTCTATTTTCAGTCATAGGTTTATGGATATCGCCCTCCAGATGGGTACTCAATTGAGGAAAACTTCTGTTTCAACTAACGTCAAAGAGAGATTAGATTTTTCATGTGCACTATTCGACTCTAAAGGAAACTTAGTCGCTAACGCTCCTCATGTACCTGTTCACTTAGGATCAATGTCAACCTGCATATCAGCACAGGCGAAGTTATGGGAAGGCAAATTAAAGCCTGGTGATGTTTTAATCACAAACCATCCGGATATTGGTGGTACTCATTTACCAGACATAACAGTAATAACTCCTTCTTTCTCTTCAACTGGCGAATTGATATTTTATGTGGCTTCAAGAGCCCATCATGCAGATATTGGAGGTATTCTACCCGGTTCAGTGCCTCCAAATTCCAAAGAATTGTACGAAGAAGGAACCGCAATTTATTCCGAATTGGTTGTCAAAGAGGGAATTTTCCAGGAAGAATTAATTTACAAGCTTTTCGTAGAAGATCCAGGCAAATACCCAGGCTGCTCAGGTTCAAGAAGATTTAGTGATAACATAAGCGATTTAAAAGCGCAAGTCGCAGCTAACACAAAAGGGATACAGTTAATTGGGTCATTAACTAAGGAATATGATCTGGCTACAATATTGAAATACATGGCTGCAATTCAGACAAATGCATCTGAATCCATAAAAAAAATGCTTGCAAAAATGGTTGAACATTTTGGCACAACGAAGTTTTCTGGCGAAGATCGCTTAGATGATGGAAGCTTAATTAAACTACAAGTTATCATAAGACCTGAAAAAGAGGAGTATATTTTTAATTTCGATGGCACTTCTCCCCAAGTTTATGGTAATTTAAATGCACCAGAGGCTATTACTAATTCTGCGATTCTTTATTGTCTACGGTGTCTAGTAGGCGAAGATATTCCTTTAAATCAAGGTTGTTTAAAACCCTTAACAATAAAAATTCCTGCTGGTTCCCTCTTGAGCCCCCGATCCGGTGCTGCTGTTGTCGGAGGCAATGTATTAACTTCCCAAAGAGTGACAGATGTAATCTTAAAAACATTTAACGTCATGGCAGATTCTCAAGGTGACTGTAACAACTTTACATTTGGAACTGGAGGAAATTCTGGTAACAAAACCGATAAGCAGATCAAAGGCTTTGGATATTATGAAACCATATGTGGCGGCTCGGGGGCTGGTGCAGATTCATGGAGAGGAAGTGGTTGGAATGGCTCAGACGCTGTACACACGAATATGACCAATACAAGAATGACAGATACTGAGGTATTTGAAAGGAGATACCCCGTTCTGTTGAAAGAGTTCTCGATCAGAAGAGGTTCAGGAGGCAAAGGTAAATATACTGGCGGAAATGGCGTAGTAAGGGATGTTCAATTTCGGAAGGCTGTAACAGCATCTATATTATCAGAACGTCGTGTCATTGGCCCTCATGGTATAAAGGGAGGACAAGACGGTAGTAGAGGTGAGAATTTATGGGTAAGACATAGCACAGGCGCATTAATCAATGTCGGCGGTAAAAATACGATTTACGCTCAACCCGGTGATCGATTCATCATTAAAACCCCTGGTGGTGGGGGATTTGGACAATACAAGGATTAA","protein_sequence":"MQKGNIRIAIDKGGTFTDCVGNIGTGKQEHDTVIKLLSVDPKNYPDAPLEGIRRLLEVLEHKTIPRGIPLDISNVRSLRMGTTLATNCALERNGERCAFITTKGFKDSLLIGDQTRPDIFNLNIKKVVPLYDTVVEIDERVTLEDFSEDPYFTKSSPNEQEGILEGNSGEMVRVIKKPDESSVRSILKVLYASGIKSIAIAFLHSYTFPDHERIVGNIAREIGFSHVSLSSEVSPMIKFLPRAHSSVADAYLTPVIKKYLNSISAGLSHAEDTHIQFMQSDGGLVDGGKFSGLKSILSGPAGGVIGYSSTCYDKNNNIPLIGFDMGGTSTDVSRYGDGRLEHVFETVTAGIIIQSPQLDIHTVAAGGSSILSWKNGLFRVGPDSAAADPGPAAYRKGGPLTITDANLFLGRLVPEFFPKIFGPNEDESLDLETTTLKFRELTDVINKDLNSNLTMEEVAYGFIKVANECMARPVRAITEAKGHVVSQHRLVSFGGAGGQHAIAVADSLGIDTVLIHRYSSILSAYGIFLADVIEENQEPCSFILGEPETILKVKKRFLELSKNSIKNLLSQSFSREDIVLERYLNLRYEGTETSLMILQKYDDQWNFREWFSEAHKKEFGFSFDDKRIIIDDIRIRAIGKSGVRKEKTVDEQLIEISHFKKADVSKDASFTQKAYFDNKWVDTAVFKIDDLPAGTIIEGPAILADGTQTNIILPNSQATILNSHIFIKINQKAAKTLSKSGYELDIDPILLSIFSHRFMDIALQMGTQLRKTSVSTNVKERLDFSCALFDSKGNLVANAPHVPVHLGSMSTCISAQAKLWEGKLKPGDVLITNHPDIGGTHLPDITVITPSFSSTGELIFYVASRAHHADIGGILPGSVPPNSKELYEEGTAIYSELVVKEGIFQEELIYKLFVEDPGKYPGCSGSRRFSDNISDLKAQVAANTKGIQLIGSLTKEYDLATILKYMAAIQTNASESIKKMLAKMVEHFGTTKFSGEDRLDDGSLIKLQVIIRPEKEEYIFNFDGTSPQVYGNLNAPEAITNSAILYCLRCLVGEDIPLNQGCLKPLTIKIPAGSLLSPRSGAAVVGGNVLTSQRVTDVILKTFNVMADSQGDCNNFTFGTGGNSGNKTDKQIKGFGYYETICGGSGAGADSWRGSGWNGSDAVHTNMTNTRMTDTEVFERRYPVLLKEFSIRRGSGGKGKYTGGNGVVRDVQFRKAVTASILSERRVIGPHGIKGGQDGSRGENLWVRHSTGALINVGGKNTIYAQPGDRFIIKTPGGGGFGQYKD"},{"created_at":"2011-05-26T20:31:54.000Z","updated_at":"2011-05-27T15:01:09.000Z","name":"Glutamate 5-kinase","uniprot_id":"P32264","uniprot_name":"PROB_YEAST","enzyme":true,"transporter":false,"gene_name":"PRO1","num_residues":428,"molecular_weight":"47161.69922","theoretical_pi":"6.75","general_function":"Involved in cellular amino acid biosynthetic process","specific_function":"Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline","reactions":[{"id":1570,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2597,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + L-glutamate = ADP + L-glutamate 5-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3716,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006232","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"M85293","genbank_protein_id":"172241","gene_card_id":"PRO1","chromosome_location":"chromosome 4","locus":"YDR300C","synonyms":["GK","Gamma-glutamyl kinase"],"enzyme_classes":["2.7.2.11"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" glutamate 5-kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" phosphotransferase activity, carboxyl group as acceptor"},{"category":"Process","description":" proline metabolic process"},{"category":"Process","description":" proline biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"}],"pfams":[{"name":"AA_kinase","identifier":"PF00696"},{"name":"PUA","identifier":"PF01472"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Proline Metabolism","kegg_map_id":null}],"gene_sequence":"ATGAAGGATGCTAATGAGAGTAAATCGTATACTATAGTGATCAAATTAGGCTCTTCATCGCTAGTAGATGAAAAAACCAAAGAACCTAAGTTAGCTATCATGTCGCTTATTGTCGAAACTGTAGTCAAATTGAGAAGAATGGGACACAAAGTTATCATCGTGTCCAGTGGTGGTATTGCTGTTGGTTTGAGGACTATGCGTATGAATAAAAGACCAAAACATTTAGCAGAAGTTCAGGCCATCGCAGCTATTGGGCAGGGTAGATTGATCGGGAGATGGGATCTTCTGTTTTCGCAATTTGATCAACGTATCGCTCAAATTCTATTGACCAGAAATGATATTCTGGACTGGACCCAATATAAGAACGCTCAAAACACAATTAATGAATTGTTGAACATGGGCGTTATTCCCATTGTGAATGAAAACGACACACTATCTGTTAGAGAAATCAAATTTGGTGACAATGACACTTTATCAGCAATTACTTCTGCTTTAATCCATGCAGATTATCTTTTCTTACTGACAGATGTTGACTGTTTGTATACTGATAATCCAAGGACAAACCCAGATGCCATGCCGATCTTAGTTGTCCCAGATCTCTCAAAGGGTTTGCCCGGTGTGAATACTGCTGGTGGTTCAGGTTCTGACGTTGGGACCGGTGGTATGGAAACTAAATTGGTTGCTGCAGATTTGGCAACGAATGCCGGTGTTCATACGTTGATCATGAAAAGCGATACACCTGCGAATATAGGTAGAATTGTCGAGTATATGCAAACTCTAGAACTTGACGATGAAAATAAAGTTAAACAAGCATATAATGGCGATTTAACGGATTTGCAAAAAAGAGAATTTGAGAAATTAAAGGCTCTTAACGTTCCACTACATACGAAGTTCATTGCTAATGATAATAAACACCATCTAAAGAATAGAGAGTTTTGGATTTTACACGGTCTTGTCTCTAAAGGCGCTGTTGTTATAGACCAAGGTGCGTACCGAGCCTTAACAAGGAAAAATAAGGCGGGATTATTGCCAGCAGGTGTTATTGATGTTCAGGGCACTTTCCATGAGTTAGAATGTGTTGACATAAAAGTTGGTAAAAAGTTACCAGATGGCACGTTAGATCCAGATTTTCCCTTGCAAACAGTAGGCAAGGCAAGATGCAATTACACGAGTTCTGAATTAACTAAAATTAAAGGTTTGCACAGTGACCAAATCGAAGAGGAATTGGGCTATAATGACAGCGAATATGTCGCTCATAGAGAAAATTTGGCATTCCCACCTCGTTGA","protein_sequence":"MKDANESKSYTIVIKLGSSSLVDEKTKEPKLAIMSLIVETVVKLRRMGHKVIIVSSGGIAVGLRTMRMNKRPKHLAEVQAIAAIGQGRLIGRWDLLFSQFDQRIAQILLTRNDILDWTQYKNAQNTINELLNMGVIPIVNENDTLSVREIKFGDNDTLSAITSALIHADYLFLLTDVDCLYTDNPRTNPDAMPILVVPDLSKGLPGVNTAGGSGSDVGTGGMETKLVAADLATNAGVHTLIMKSDTPANIGRIVEYMQTLELDDENKVKQAYNGDLTDLQKREFEKLKALNVPLHTKFIANDNKHHLKNREFWILHGLVSKGAVVIDQGAYAALTRKNKAGLLPAGVIDVQGTFHELECVDIKVGKKLPDGTLDPDFPLQTVGKARCNYTSSELTKIKGLHSDQIEEELGYNDSEYVAHRENLAFPPR"},{"created_at":"2011-05-26T23:59:10.000Z","updated_at":"2011-05-27T15:01:12.000Z","name":"Probable folylpolyglutamate synthase","uniprot_id":"P36001","uniprot_name":"FOLC_YEAST","enzyme":true,"transporter":false,"gene_name":"RMA1","num_residues":430,"molecular_weight":"48142.89844","theoretical_pi":"7.16","general_function":"Involved in tetrahydrofolylpolyglutamate synthase activity","specific_function":"Conversion of folates to polyglutamate derivatives","reactions":[{"id":2486,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion. Cytoplasm;Mitochondrion","altext":"ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"Z28131","genbank_protein_id":"486223","gene_card_id":"RMA1","chromosome_location":"chromosome 11","locus":"YKL132C","synonyms":["Folylpoly-gamma-glutamate synthetase","FPGS","Tetrahydrofolylpolyglutamate synthase","Tetrahydrofolate synthase"],"enzyme_classes":["6.3.2.17"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" tetrahydrofolylpolyglutamate synthase activity"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"}],"pfams":[],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"}],"gene_sequence":"ATGGATGATATAAGCGGAAGGCAAACTTTACCTCGAATAAACCGTTTGTTGGAGCACGTGGGAAATCCCCAAGATAGTTTGTCAATCCTACATATAGCGGGAACAAATGGTAAGGAGACAGTATCTAAATTTTTGACATCCATATTGCAGCATCCGGGGCAACAGCGGCAAAGGGTCTTGATTGGTAGGTATACTACATCTTCCTTGCTAAACGCCAAAGAAGAGGATATTAGCATTAATAATGAAGCCATTTCCTTGATAGAGTATTCTAGGATCGAGAAGGAACTTATAGAAGCAGATAGTTCTTTGAAATTACAGTGCAACAACCTCGAACTGCTAACAAGCGTAGCTCTCGTATACTTCGCTAAGAAAAATTGCCAATGGTGCATAATAGAAACTGGTTTAGCTGGAAAACAGGACCCTGGAAGTATAATTGCTGGTCAAAGTAGAGTCTGTTGCGCCATTACTAACGTGGGCATTAGCGATGAAGCTTTTTTATGCAAGTTTTTGTCTCAAATTACTGAAAGTTCCACAAATAAAGCAATTTTTCTATTAGACGGTTCTAATGACGAATTTGTACGAAATACGATAACGAAACGGTGCCATGATGTTGGATGTCCATTAGAAATCACCGACCCTTCTCTTAGGGATTACAATGTACACACAGACACATGGGGCACTCTTGAAGTTCGCCTGCCATACAGTGAAGAAGAATATCAAATATTTAATTTGAGAGTTGCGATAGCGGTTTTAGACTTTTTGAGCAAGGAAAAAAAGGTTTGTATTTCAAAGGATCAACTATCCCAAGGTTTAATATCTGTGGATTGGCCAAGAAGTTTACATCGCTTGGATTACTGTTATGAATCTACTAGTGGAAAGAAAATCGCATTACTATTAGACAACGCAAATAATGCGAAGGCAGCTCGAAATTTAGCCTGCCATTTAAGGACCACGTACGGTGATACGCCATTAACATTTGTCATTGCTATAACAACTGGGAAAAAGGTGTCTCCCTTACTTGATCCGCTAATACGTCCACAAGATTATGTTATTGTGACTAGATTTGGGTCAGTGGTTGGAATGCCGTGGATCCAATCCCTAGAACCGGTGAATCTTCTCGCATTTATCAAAAACCGGTATACGAGAAATGTTAACATGCAGCCGGATCTTCAAAGTGTCTGGACCTTCCTTGAAACAAGTGGGTTAAAGACGATTGTTCCTGTTATCGTATGTGGATCACTGTATATCTGCAAAGAGCTATTGCGCTTACACAACTGTCACTTGCCAGTATAG","protein_sequence":"MDDISGRQTLPRINRLLEHVGNPQDSLSILHIAGTNGKETVSKFLTSILQHPGQQRQRVLIGRYTTSSLLNAKEEDISINNEAISLIEYSRIEKELIEADSSLKLQCNNLELLTSVALVYFAKKNCQWCIIETGLAGKQDPGSIIAGQSRVCCAITNVGISDEAFLCKFLSQITESSTNKAIFLLDGSNDEFVRNTITKRCHDVGCPLEITDPSLRDYNVHTDTWGTLEVRLPYSEEEYQIFNLRVAIAVLDFLSKEKKVCISKDQLSQGLISVDWPRSLHRLDYCYESTSGKKIALLLDNANNAKAARNLACHLRTTYGDTPLTFVIAITTGKKVSPLLDPLIRPQDYVIVTRFGSVVGMPWIQSLEPVNLLAFIKNRYTRNVNMQPDLQSVWTFLETSGLKTIVPVIVCGSLYICKELLRLHNCHLPV"},{"created_at":"2011-05-27T02:02:29.000Z","updated_at":"2011-05-27T15:01:16.000Z","name":"General amino acid permease AGP3","uniprot_id":"P43548","uniprot_name":"AGP3_YEAST","enzyme":false,"transporter":true,"gene_name":"AGP3","num_residues":558,"molecular_weight":"61051.19922","theoretical_pi":"7.58","general_function":"Involved in transport","specific_function":"General amino acid permease with broad substrate specificity","reactions":[],"signal_regions":"None","transmembrane_regions":"58-78;82-102;127-147;169-189;194-214;242-262;281-301;325-345;376-396;403-423;447-467;481-501","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"D50617","genbank_protein_id":"836700","gene_card_id":"AGP3","chromosome_location":"chromosome 6","locus":"YFL055W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGCAGTCCTTAACTTGAAACGTGAAACTGTCGACATTGAAGAGACAGCGAAGAAAGATATCAAACCTTATTTTGCTTCGAATGTTGAAGCGGTTGATATTGATGAAGATCCCGATGTTTCAAGATACGATCCCCAGACAGGAGTGAAAAGGGCGCTCAAAAATAGGCATATCTCATTGCTAGCTTTGGGTGGTGTTATTGGCCCAGGTTGTCTTGTTGGTGCAGGAAACGCACTCAACAAAGGTGGGCCACTTGCTTTACTTTTAGGCTTTAGTATTATTGGGATCATTGCTTTCTCAGTGATGGAATCTATAGGTGAAATGATCACTTTATATCCCTCGGGCGGTGGATTTACCACTTTGGCTCGAAGATTTCATAGCGATGCACTGCCTGCAGTTTGCGGTTATGCTTACGTTGTTGTGTTCTTCGCAGTTTTGGCAAATGAGTACAACACTCTCTCCTCCATACTACAGTTTTGGGGCCCACAAGTCCCTCTATATGGTTACATCTTGATATTCTGGTTTGCATTTGAAATTTTTCAACTAGTTGGCGTTGGTCTTTTTGGTGAAACGGAGTACTGGCTTGCTTGGTTGAAAATAGTAGGATTAGTAGCCTATTATATTTTCTCGATTGTTTACATATCTGGGGATATTAGGAATAGACCAGCTTTCGGCTTTCATTATTGGAATAGTCCAGGTGCATTATCACATGGGTTTAAGGGAATTGCGATAGTGTTTGTGTTTTGTTCGACCTTCTATTCTGGAACGGAATCAGTTGCCTTGGCTGCAACGGAATCAAAAAACCCTGGGAAGGCTGTGCCACTTGCTGTTCGACAAACTCTGTGGAGAATTTTAGTTGTTTATATTGGAATTGCTGTTTTCTATGGAGCAACTGTTCCGTTTGACGACCCAAACCTCTCTGCTTCTACCAAAGTCCTAAAATCTCCCATTGCTATCGCCATATCTCGTGCTGGTTGGGCCGGCGGAGCTCATCTGGTTAATGCCTTCATTTTGATAACTTGCATCTCCGCCATTAATGGGTCACTTTATATAGGGAGCAGAACCTTGACGCATTTAGCACATGAAGGCCTAGCTCCAAAAATTCTGGCTTGGACCGATCGAAGAGGCGTTCCCATCCCCGCCATCACTGTTTTCAACGCCTTGGGCCTAATATCATTGATGAATGTGAGCGTTGGAGCTGCAAATGCGTACTCTTATATCGTTAATCTTTCTGGTGTTGGCGTCTTTATTGTCTGGGGTGTAATAAGTTATACGCACCTGAGAATAAGGAAGGCGTGGGTTGCTCAAGGAAGATCCATAGAAGAGCTACCTTATGAAGCGCTATTTTATCCGTGGACGCCAGTACTTAGTCTGGCCGCTAACATTTTTCTAGCACTCATCCAAGGATGGAGCTATTTCGTACCTTTTGATGCGGGCAATTTTGTTGATGCTTATATCCTTCTGCCTGTTGGAATTTTATTGTATATTGGCATATGTGTTTTTAAGAGCAATCATTTTAGAACTGTTGATTTGCGGTCAATCAACCTAGACGAAGGACGAAGAAAAGACATGGAGGCTGATCTTTCTGATCAAGAGAGTAGCTTAGCATCTTCGGAAACGATGAAGGATTATAAAAGTGCAACTTTTTTCAGATACCTCAGCAACATTTTCACCTGA","protein_sequence":"MAVLNLKRETVDIEETAKKDIKPYFASNVEAVDIDEDPDVSRYDPQTGVKRALKNRHISLLALGGVIGPGCLVGAGNALNKGGPLALLLGFSIIGIIAFSVMESIGEMITLYPSGGGFTTLARRFHSDALPAVCGYAYVVVFFAVLANEYNTLSSILQFWGPQVPLYGYILIFWFAFEIFQLVGVGLFGETEYWLAWLKIVGLVAYYIFSIVYISGDIRNRPAFGFHYWNSPGALSHGFKGIAIVFVFCSTFYSGTESVALAATESKNPGKAVPLAVRQTLWRILVVYIGIAVFYGATVPFDDPNLSASTKVLKSPIAIAISRAGWAGGAHLVNAFILITCISAINGSLYIGSRTLTHLAHEGLAPKILAWTDRRGVPIPAITVFNALGLISLMNVSVGAANAYSYIVNLSGVGVFIVWGVISYTHLRIRKAWVAQGRSIEELPYEALFYPWTPVLSLAANIFLALIQGWSYFVPFDAGNFVDAYILLPVGILLYIGICVFKSNHFRTVDLRSINLDEGRRKDMEADLSDQESSLASSETMKDYKSATFFRYLSNIFT"},{"created_at":"2011-05-27T02:15:50.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Aromatic amino acid aminotransferase 2","uniprot_id":"P38840","uniprot_name":"ARO9_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO9","num_residues":513,"molecular_weight":"58527.0","theoretical_pi":"5.16","general_function":"Involved in transferase activity, transferring nitrogenous groups","specific_function":"Has aromatic amino acid transaminase activity and kynurenine aminotransferase activity","reactions":[{"id":1839,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2024,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2027,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2667,"direction":"\u003e","locations":"Cytoplasm","altext":"An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3787,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006309","source":"Smpdb"},{"id":3788,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006518","source":"Smpdb"},{"id":3789,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006523","source":"Smpdb"},{"id":3790,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006536","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U10398","genbank_protein_id":"500670","gene_card_id":"ARO9","chromosome_location":"chromosome 8","locus":"YHR137W","synonyms":["Aromatic amino acid aminotransferase II","Aromatic amino acid-requiring protein 9"],"enzyme_classes":["2.6.1.57"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACTGCTGGTTCTGCCCCCCCTGTTGATTACACTTCCTTAAAGAAGAACTTCCAACCGTTTCTCTCCAGAAGAGTAGAAAATAGATCTCTGAAAAGCTTTTGGGATGCTTCTGATATCTCAGATGACGTCATTGAGCTAGCTGGTGGAATGCCAAACGAGAGATTTTTTCCTATCGAATCTATGGATTTGAAAATATCAAAAGTTCCTTTTAATGATAACCCAAAATGGCATAATTCGTTTACCACGGCGCATTTGGACTTGGGATCCCCCAGTGAGCTACCCATTGCACGTTCTTTCCAATATGCAGAAACCAAGGGTTTACCCCCTCTCTTACATTTTGTTAAAGATTTTGTGTCCAGAATTAATCGCCCAGCCTTTTCCGATGAGACGGAGTCTAACTGGGATGTCATCCTTTCTGGCGGGTCCAACGATTCAATGTTTAAGGTTTTTGAAACAATTTGCGACGAATCGACCACTGTGATGATTGAAGAGTTTACTTTCACCCCGGCTATGTCCAATGTGGAGGCTACAGGAGCAAAAGTCATCCCCATCAAGATGAACCTGACCTTCGACAGAGAGTCCCAGGGTATTGATGTCGAATATCTAACGCAGTTGCTCGATAATTGGTCAACTGGACCATACAAAGACTTAAACAAGCCAAGGGTCCTATATACCATTGCAACGGGCCAAAATCCTACCGGGATGTCTGTCCCCCAGTGGAAAAGAGAGAAAATTTACCAGTTGGCCCAAAGACACGATTTCCTCATTGTTGAAGATGATCCCTACGGTTATCTGTACTTTCCTTCCTATAATCCGCAAGAGCCATTAGAAAACCCTTACCATTCTAGCGACCTGACTACTGAACGGTATTTGAATGATTTTTTAATGAAATCATTCTTGACTTTGGATACAGATGCCCGTGTCATCCGTTTGGAGACTTTTTCTAAAATTTTTGCTCCTGGATTAAGGTTATCCTTCATCGTTGCTAATAAATTCCTTTTGCAAAAAATCTTGGATTTGGCCGACATTACTACAAGGGCCCCCAGTGGTACCTCACAAGCTATTGTTTATTCTACAATAAAGGCAATGGCTGAGTCCAACTTATCGTCCTCTCTTTCTATGAAAGAAGCAATGTTTGAGGGTTGGATAAGATGGATAATGCAGATTGCTTCTAAATACAATCATAGGAAAAATCTTACTTTGAAAGCCTTATACGAAACAGAATCTTACCAAGCTGGTCAGTTTACCGTTATGGAACCCTCCGCGGGTATGTTCATCATTATTAAAATCAATTGGGGGAATTTCGATAGACCTGACGATTTGCCGCAACAGATGGATATTTTAGATAAGTTCTTGCTGAAGAATGGTGTTAAAGTAGTGCTTGGTTATAAAATGGCTGTTTGCCCAAATTATTCAAAGCAGAATTCAGATTTTCTAAGACTCACCATCGCCTATGCAAGGGATGATGATCAGTTGATTGAAGCTTCCAAAAGAATCGGTAGTGGCATAAAAGAATTTTTTGACAACTATAAAAGTTGA","protein_sequence":"MTAGSAPPVDYTSLKKNFQPFLSRRVENRSLKSFWDASDISDDVIELAGGMPNERFFPIESMDLKISKVPFNDNPKWHNSFTTAHLDLGSPSELPIARSFQYAETKGLPPLLHFVKDFVSRINRPAFSDETESNWDVILSGGSNDSMFKVFETICDESTTVMIEEFTFTPAMSNVEATGAKVIPIKMNLTFDRESQGIDVEYLTQLLDNWSTGPYKDLNKPRVLYTIATGQNPTGMSVPQWKREKIYQLAQRHDFLIVEDDPYGYLYFPSYNPQEPLENPYHSSDLTTERYLNDFLMKSFLTLDTDARVIRLETFSKIFAPGLRLSFIVANKFLLQKILDLADITTRAPSGTSQAIVYSTIKAMAESNLSSSLSMKEAMFEGWIRWIMQIASKYNHRKNLTLKALYETESYQAGQFTVMEPSAGMFIIIKINWGNFDRPDDLPQQMDILDKFLLKNGVKVVLGYKMAVCPNYSKQNSDFLRLTIAYARDDDQLIEASKRIGSGIKEFFDNYKS"},{"created_at":"2011-05-27T02:16:21.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Aromatic amino acid aminotransferase 1","uniprot_id":"P53090","uniprot_name":"ARO8_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO8","num_residues":500,"molecular_weight":"56177.30078","theoretical_pi":"5.86","general_function":"Involved in transferase activity, transferring nitrogenous groups","specific_function":"Has aromatic amino acid transaminase activity. Also active with methionine, alpha-aminoadipate and leucine when phenylpyruvate is the amino acceptor","reactions":[{"id":1839,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2024,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2027,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2667,"direction":"\u003e","locations":"Cytoplasm","altext":"An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2668,"direction":"\u003e","locations":"Cytoplasm","altext":"L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate","export":false,"pw_reaction_id":null,"source":null},{"id":14093,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006519","source":"Smpdb"},{"id":14094,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006524","source":"Smpdb"},{"id":14095,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006535","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692962","genbank_protein_id":"51013375","gene_card_id":"ARO8","chromosome_location":"chromosome 7","locus":"YGL202W","synonyms":["Aromatic amino acid aminotransferase I","Aromatic amino acid-requiring protein 8"],"enzyme_classes":["2.6.1.57","2.6.1.39"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACTTTACCTGAATCAAAAGACTTTTCTTACTTGTTTTCGGATGAAACCAATGCTCGTAAACCATCCCCATTGAAAACCTGCATCCATCTTTTCCAAGATCCTAACATTATCTTTTTGGGTGGTGGCCTGCCATTAAAAGATTATTTCCCATGGGATAATCTATCTGTAGATTCACCCAAGCCTCCTTTTCCCCAGGGTATTGGAGCTCCAATTGACGAGCAGAATTGCATAAAATACACCGTCAACAAAGATTACGCTGATAAAAGTGCCAATCCTTCCAACGATATTCCTTTGTCAAGAGCTTTGCAATACGGGTTCAGTGCTGGTCAACCTGAACTATTAAACTTCATTAGAGATCATACCAAGATTATCCACGATTTGAAGTATAAGGACTGGGACGTTTTAGCCACTGCAGGTAACACAAATGCCTGGGAATCTACTTTAAGAGTCTTTTGTAACCGAGGTGATGTCATCTTAGTTGAGGCACATTCTTTTTCCTCTTCATTGGCTTCTGCAGAGGCTCAAGGTGTCATTACCTTCCCCGTGCCAATTGACGCTGATGGTATCATTCCTGAAAAATTAGCTAAAGTCATGGAAAACTGGACACCTGGTGCTCCTAAACCAAAGTTGTTATACACTATTCCAACGGGCCAAAATCCAACTGGTACTTCCATTGCAGACCATAGAAAGGAGGCAATTTACAAGATCGCTCAAAAGTACGACTTCCTAATTGTGGAAGATGAACCTTATTATTTCTTACAAATGAATCCCTACATCAAAGACTTGAAGGAAAGAGAGAAGGCACAAAGTTCTCCAAAGCAGGACCATGACGAATTTTTGAAGTCCTTGGCAAACACTTTCCTTTCCTTGGATACAGAAGGCCGTGTTATTAGAATGGATTCCTTTTCAAAAGTTTTGGCCCCAGGGACAAGATTGGGTTGGATTACTGGTTCATCCAAAATCTTGAAGCCTTACTTGAGTTTGCATGAAATGACGATTCAAGCCCCAGCAGGTTTTACACAAGTTTTGGTCAACGCTACGCTATCCAGGTGGGGTCAAAAGGGTTACTTGGACTGGTTGCTTGGCCTGCGTCATGAATACACTTTGAAACGTGACTGTGCCATCGATGCCCTTTACAAGTATCTACCACAATCTGATGCTTTCGTGATCAATCCTCCAATTGCAGGTATGTTTTTCACCGTGAACATTGACGCATCTGTCCACCCTGAGTTTAAAACAAAATACAACTCAGACCCTTACCAGCTAGAACAGAGTCTTTACCACAAAGTGGTTGAACGTGGTGTTTTAGTGGTTCCCGGTTCTTGGTTCAAGAGTGAGGGTGAGACGGAACCTCCTCAACCCGCTGAATCTAAAGAAGTCAGTAATCCAAACATAATTTTCTTCAGAGGTACCTATGCAGCTGTCTCTCCTGAGAAACTGACTGAAGGTCTGAAGAGATTAGGTGATACTTTATACGAAGAATTTGGTATTTCCAAATAG","protein_sequence":"MTLPESKDFSYLFSDETNARKPSPLKTCIHLFQDPNIIFLGGGLPLKDYFPWDNLSVDSPKPPFPQGIGAPIDEQNCIKYTVNKDYADKSANPSNDIPLSRALQYGFSAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNAWESTLRVFCNRGDVILVEAHSFSSSLASAEAQGVITFPVPIDADGIIPEKLAKVMENWTPGAPKPKLLYTIPTGQNPTGTSIADHRKEAIYKIAQKYDFLIVEDEPYYFLQMNPYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLDTEGRVIRMDSFSKVLAPGTRLGWITGSSKILKPYLSLHEMTIQAPAGFTQVLVNATLSRWGQKGYLDWLLGLRHEYTLKRDCAIDALYKYLPQSDAFVINPPIAGMFFTVNIDASVHPEFKTKYNSDPYQLEQSLYHKVVERGVLVVPGSWFKSEGETEPPQPAESKEVSNPNIIFFRGTYAAVSPEKLTEGLKRLGDTLYEEFGISK"},{"created_at":"2011-05-27T02:29:27.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial","uniprot_id":"P07275","uniprot_name":"PUT2_YEAST","enzyme":true,"transporter":false,"gene_name":"PUT2","num_residues":575,"molecular_weight":"64434.60156","theoretical_pi":"7.0","general_function":"Involved in oxidoreductase activity","specific_function":"(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H","reactions":[{"id":1437,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1685,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1688,"direction":"\u003c\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1698,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1699,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2676,"direction":"\u003e","locations":"Mitochondrion inner membrane","altext":"(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":3772,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006294","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane","genbank_gene_id":"M10029","genbank_protein_id":"172303","gene_card_id":"PUT2","chromosome_location":"chromosome 8","locus":"YHR037W","synonyms":["P5C dehydrogenase"],"enzyme_classes":["1.5.1.12"],"go_classes":[{"category":"Component","description":" mitochondrial part"},{"category":"Component","description":" mitochondrial matrix"},{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasmic part"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase 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and proline metabolism","kegg_map_id":"00330"},{"name":"4-aminobutanoate 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Important for metabolite exchange between mitochondria and cytosol","reactions":[{"id":1335,"direction":"\u003c\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1696,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2027,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2692,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm. 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Peroxisome.","altext":"L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1YAA","cellular_location":"Cytoplasm. Peroxisome.","genbank_gene_id":"Z73199","genbank_protein_id":"1360338","gene_card_id":"AAT2","chromosome_location":"chromosome 12","locus":"YLR027C","synonyms":["Transaminase A"],"enzyme_classes":["2.6.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"}],"gene_sequence":"ATGAACAAAAGAACACAGGAATACAAGAACACAAGAGCGATAATGTCTGCCACTCTGTTCAATAACATCGAATTGCTGCCCCCTGATGCCCTTTTTGGTATTAAGCAAAGGTACGGGCAAGATCAACGTGCTACCAAGGTCGACTTGGGTATCGGGGCCTACAGAGACGACAACGGTAAACCATGGGTCTTGCCAAGTGTTAAAGCCGCCGAAAAGCTAATTCATAACGACAGCTCCTACAACCATGAATACCTCGGTATTACCGGTCTGCCAAGTTTGACATCTAACGCCGCCAAGATCATCTTCGGTACGCAATCCGATGCCTTTCAGGAAGACAGAGTAATCTCAGTACAATCACTGTCTGGTACGGGTGCTCTTCATATATCTGCGAAGTTTTTTTCAAAATTCTTCCCAGATAAACTGGTCTATTTGTCTAAGCCTACTTGGGCCAACCACATGGCCATTTTTGAGAATCAAGGCTTGAAAACGGCGACTTACCCTTACTGGGCCAACGAAACTAAGTCTTTGGACCTAAACGGCTTTCTAAATGCTATTCAAAAAGCTCCAGAGGGCTCCATTTTCGTTCTGCACTCTTGCGCCCATAACCCAACTGGTCTGGACCCTACTAGTGAACAATGGGTTCAAATCGTTGATGCTATCGCCTCAAAGAACCACATCGCCTTATTTGACACCGCCTACCAAGGGTTTGCCACTGGAGATTTGGACAAGGATGCCTATGCTGTGCGTCTAGGTGTGGAGAAGCTTTCAACGGTCTCTCCCGTCTTTGTCTGTCAGTCCTTTGCCAAGAACGCCGGTATGTACGGTGAGCGTGTAGGTTGTTTCCATCTAGCACTTACAAAACAAGCTCAAAACAAAACTATAAAGCCTGCTGTTACATCTCAATTGGCCAAAATCATTCGTAGTGAAGTGTCCAACCCACCCGCCTACGGCGCTAAGATTGTCGCTAAACTGTTGGAAACGCCAGAATTAACGGAACAGTGGCACAAGGATATGGTTACCATGTCCTCCAGAATTACGAAAATGAGGCACGCATTAAGAGACCATTTAGTCAAGTTGGGCACTCCTGGCAACTGGGATCATATAGTAAATCAATGCGGGATGTTCTCCTTTACAGGATTGACTCCTCAAATGGTTAAACGACTTGAAGAAACCCACGCAGTTTACTTGGTTGCCTCAGGTAGAGCTTCTATTGCTGGATTGAATCAAGGAAACGTGGAATACGTGGCTAAAGCCATTGATGAAGTGGTGCGCTTCTATACTATTGAAGCTAAATTGTAA","protein_sequence":"MSATLFNNIELLPPDALFGIKQRYGQDQRATKVDLGIGAYRDDNGKPWVLPSVKAAEKLIHNDSSYNHEYLGITGLPSLTSNAAKIIFGTQSDAFQEDRVISVQSLSGTGALHISAKFFSKFFPDKLVYLSKPTWANHMAIFENQGLKTATYPYWANETKSLDLNGFLNAIQKAPEGSIFVLHSCAHNPTGLDPTSEQWVQIVDAIASKNHIALFDTAYQGFATGDLDKDAYAVRLGVEKLSTVSPVFVCQSFAKNAGMYGERVGCFHLALTKQAQNKTIKPAVTSQLAKIIRSEVSNPPAYGAKIVAKLLETPELTEQWHKDMVTMSSRITKMRHALRDHLVKLGTPGNWDHIVNQCGMFSFTGLTPQMVKRLEETHAVYLVASGRASIAGLNQGNVEYVAKAIDEVVRFYTIEAKL"},{"created_at":"2011-05-27T02:47:42.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Probable alanine aminotransferase","uniprot_id":"P52892","uniprot_name":"ALAT_YEAST","enzyme":true,"transporter":false,"gene_name":"ALT2","num_residues":507,"molecular_weight":"56769.30078","theoretical_pi":"5.53","general_function":"Involved in 1-aminocyclopropane-1-carboxylate synthase activity","specific_function":"L-alanine + 2-oxoglutarate = pyruvate + L- glutamate","reactions":[{"id":2694,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion matrix","altext":"L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY723777","genbank_protein_id":"51830240","gene_card_id":"ALT2","chromosome_location":"chromosome 4","locus":"YDR111C","synonyms":["Glutamate pyruvate transaminase","GPT","Glutamic--alanine transaminase","Glutamic--pyruvic transaminase"],"enzyme_classes":["2.6.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" carbon-sulfur lyase activity"},{"category":"Function","description":" 1-aminocyclopropane-1-carboxylate synthase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGACAATGACACACCAACAGGATTTGAAAGGTGTGTTCACCGCAAAGGATTTGGATTTTAAGCCCGCTGGCAAGATTACTAAAAAAGATTTGAATACAGGTGTCACTAAGGCAGAATATGCTGTAAGAGGAGCTATTCCAACCAGAGCTGACGAGCTAAAAGAGGAATTGAAAAAAAACCCAGAAGTTTTGCCTTTCGATGATATTATCAATGCGAACATTGGTAATCCGCAGCAACTGGATCAGAAGCCTTTGACCTTTACCAGGCAAGTACTGGCCATCCTGGAGTACCCGGAAATTTTACGAGTAGGCCATAATGAACTGGCTTCTTTGAACTTGTTTTCCAGGGACGCCTTGGAAAGAGCTGAGCGCCTCTTGAATGATATTGGCGGTTCTATAGGGGCATATTCGCATTCTCAAGGTGTGCCAGGAATAAGGCAAACAGTTGCTGACTTCATTACTAGAAGAGACGGCGGTGAGCCCGCTACACCGGAAGATATTTATTTAACCACTGGCGCTTCGTCCGCGGCAACTTCTTTGTTATCTTTATTGTGTAAAGATTCTCAAACAGGCCTGCTGATTCCAATTCCGCAGTATCCGCTTTATACTGCATCCGCATCTCTTTTCAATGCACAAGTGCTGCCATACTACTTAGATGAGGAGTCAAATTGGTCTACAAACAGCGACGAAATTGAAAAAGTAGTGCAAGATGCTTTGAAAAAACAGATCAGACCATCTGTGCTGATAGTTATTAATCCAGGTAACCCAACCGGTGCAGTTCTTTCTGAAGAAACCATTGCCAGGATCTGTTTGATCGCTGCGAAATACGGCATTACAATCATTTCTGATGAGGTCTATCAAGAAAACATTTTCAACGATGTTAAATTTCATTCGATGAAGAAAGTCCTAAGAAAATTGCAGCATCTTTATCCAGGAAAATTCGATAACGTTCAGCTCGCCTCTTTACACTCCATTTCTAAAGGATTCATGGATGAGTGCGGCCAAAGAGGCGGTTACATGGAAATTATTGGGTTTTCTCAAGAAATAAGAGATGCTCTTTTCAAACTCATGTCTATATCCATATGTTCTGTTGTCACAGGACAAGCTGTGGTTGATTTAATGGTCAAACCACCCCAGCCTGGAGACGAGTCCTATGAACAAGATCATGACGAAAGGCTGAAAATTTTTCATGAAATGCGTACGAGAGCAAACTTATTGTACGAGACGTTTAAGGAACTAGAGGGTATCGAATGCCAAGAACCTCAGGGTGCAATGTATCTTTTCCCTAGGCTTGTTTTACCTAAGAAAGCTCTTTGTGAAAGCGAACGCCTTGGCATCGAACCTGATGAGTTCTATTGCACATCTTTGCTAGAATCTACAGGTATTTGTACTGTCCCAGGGTCTGGGTTCGGACAAAGACCCGGGACTTATCATGTGCGAACAACGTTTTTGGCTCCAGGGACTAAATGGATTCAAGACTGGAAAGAATTTCATCAAGATTTCTTCAGCAAGTATCGTAATTGA","protein_sequence":"MTMTHQQDLKGVFTAKDLDFKPAGKITKKDLNTGVTKAEYAVRGAIPTRADELKEELKKNPEVLPFDDIINANIGNPQQLDQKPLTFTRQVLAILEYPEILRVGHNELASLNLFSRDALERAERLLNDIGGSIGAYSHSQGVPGIRQTVADFITRRDGGEPATPEDIYLTTGASSAATSLLSLLCKDSQTGLLIPIPQYPLYTASASLFNAQVLPYYLDEESNWSTNSDEIEKVVQDALKKQIRPSVLIVINPGNPTGAVLSEETIARICLIAAKYGITIISDEVYQENIFNDVKFHSMKKVLRKLQHLYPGKFDNVQLASLHSISKGFMDECGQRGGYMEIIGFSQEIRDALFKLMSISICSVVTGQAVVDLMVKPPQPGDESYEQDHDERLKIFHEMRTRANLLYETFKELEGIECQKPQGAMYLFPRLVLPKKALCESERLGIEPDEFYCTSLLESTGICTVPGSGFGQRPGTYHVRTTFLAPGTKWIQDWKEFHQDFFSKYRN"},{"created_at":"2011-05-27T02:48:15.000Z","updated_at":"2011-07-22T17:53:48.000Z","name":"4-aminobutyrate aminotransferase","uniprot_id":"P17649","uniprot_name":"GATA_YEAST","enzyme":true,"transporter":false,"gene_name":"UGA1","num_residues":471,"molecular_weight":"52945.69922","theoretical_pi":"6.79","general_function":"Involved in 4-aminobutyrate transaminase activity","specific_function":"Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source and for oxidative stress tolerance. Deaminates GABA to succinate semialdehyde, which in turn is converted to succinate by the succinate-semialdehyde dehydrogenase UGA2. Cannot transaminate beta-alanine (BAL)","reactions":[{"id":1192,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2695,"direction":"\u003e","locations":"Cytoplasm","altext":"4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3750,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006275","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692904","genbank_protein_id":"51013259","gene_card_id":"UGA1","chromosome_location":"chromosome 7","locus":"YGR019W","synonyms":["GABA aminotransferase","GABA-AT","Gamma-amino-N-butyrate transaminase","GABA transaminase"],"enzyme_classes":["2.6.1.19"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" 4-aminobutyrate transaminase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" gamma-aminobutyric acid metabolic process"}],"pfams":[{"name":"Aminotran_3","identifier":"PF00202"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTATTTGTGAACAATACTACCCAGAAGAGCCAACCAAACCAACTGTTAAGACCGAGTCCATTCCTGGTCCTGAATCCCAGAAGCAGTTAAAGGAACTGGGTGAAGTTTTTGACACAAGACCAGCATATTTTTTGGCTGATTATGAGAAATCTTTAGGTAACTATATCACTGATGTGGATGGGAACACATATTTGGATTTGTATGCCCAAATCTCTTCAATTGCACTTGGTTATAACAACCCTGCTTTGATCAAGGCAGCACAATCACCAGAAATGATCCGTGCTTTGGTCGACCGTCCTGCCTTAGGTAACTTCCCATCTAAGGATTTAGACAAGATATTGAAGCAAATATTGAAATCTGCGCCAAAGGGTCAAGATCACGTCTGGTCAGGGCTTTCCGGTGCAGATGCCAATGAATTAGCGTTCAAGGCTGCCTTTATTTATTACCGTGCCAAACAAAGGGGCTATGATGCCGATTTTTCTGAAAAGGAAAACTTGTCTGTCATGGACAATGACGCCCCTGGCGCCCCTCATCTTGCCGTACTATCGTTCAAGAGAGCGTTCCACGGTAGATTGTTTGCCTCCGGTTCCACAACTTGTTCTAAACCAATTCACAAGTTGGATTTCCCAGCCTTCCACTGGCCTCATGCTGAGTATCCATCTTACCAATACCCATTAGATGAAAATTCTGATGCAAACCGTAAAGAGGATGACCATTGCTTGGCCATTGTTGAAGAATTAATCAAAACCTGGTCTATTCCAGTTGCTGCCTTAATCATCGAACCAATTCAATCTGAGGGAGGTGATAACCACGCTTCTAAGTATTTCTTACAAAAGCTAAGAGACATTACCTTGAAGTATAACGTTGTCTACATCATAGATGAAGTGCAAACAGGTGTCGGAGCCACCGGTAAGCTATGGTGTCATGAGTACGCCGATATTCAACCACCTGTGGATTTAGTGACCTTTTCCAAGAAATTCCAAAGTGCAGGATATTTCTTCCACGACCCTAAATTCATTCCAAACAAACCATACAGACAATTCAACACATGGTGTGGTGAACCTGCAAGAATGATCATTGCAGGTGCCATTGGACAGGAAATCTCCGACAAGAAGTTGACTGAACAATGTTCAAGAGTAGGTGATTATTTGTTCAAGAAATTGGAGGGTTTGCAGAAGAAATACCCTGAAAACTTTCAAAACTTGAGAGGTAAAGGAAGAGGCACATTCATTGCCTGGGATTTGCCTACTGGTGAGAAGAGAGACTTACTATTGAAGAAATTGAAGTTGAATGGTTGCAACGTTGGTGGATGTGCAGTCCATGCAGTGAGATTAAGACCTTCATTAACATTCGAGGAGAAGCATGCTGATATCTTTATTGAAGCATTAGCCAAATCAGTTAATGAATTATGA","protein_sequence":"MSICEQYYPEEPTKPTVKTESIPGPESQKQLKELGEVFDTRPAYFLADYEKSLGNYITDVDGNTYLDLYAQISSIALGYNNPALIKAAQSPEMIRALVDRPALGNFPSKDLDKILKQILKSAPKGQDHVWSGLSGADANELAFKAAFIYYRAKQRGYDADFSEKENLSVMDNDAPGAPHLAVLSFKRAFHGRLFASGSTTCSKPIHKLDFPAFHWPHAEYPSYQYPLDENSDANRKEDDHCLAIVEELIKTWSIPVAALIIEPIQSEGGDNHASKYFLQKLRDITLKYNVVYIIDEVQTGVGATGKLWCHEYADIQPPVDLVTFSKKFQSAGYFFHDPKFIPNKPYRQFNTWCGEPARMIIAGAIGQEISDKKLTEQCSRVGDYLFKKLEGLQKKYPENFQNLRGKGRGTFIAWDLPTGEKRDLLLKKLKLNGCNVGGCAVHAVRLRPSLTFEEKHADIFIEALAKSVNEL"},{"created_at":"2011-05-27T02:49:04.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Probable alanine aminotransferase, mitochondrial","uniprot_id":"P52893","uniprot_name":"ALAM_YEAST","enzyme":true,"transporter":false,"gene_name":"ALT1","num_residues":592,"molecular_weight":"66421.10156","theoretical_pi":"7.02","general_function":"Involved in 1-aminocyclopropane-1-carboxylate synthase activity","specific_function":"L-alanine + 2-oxoglutarate = pyruvate + L- glutamate","reactions":[{"id":1689,"direction":"\u003c\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2694,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion matrix","altext":"L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3729,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006254","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"U53880","genbank_protein_id":"1256891","gene_card_id":"ALT1","chromosome_location":"chromosome 12","locus":"YLR089C","synonyms":["Glutamate pyruvate transaminase","GPT","Glutamic--alanine transaminase","Glutamic--pyruvic transaminase"],"enzyme_classes":["2.6.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" carbon-sulfur lyase activity"},{"category":"Function","description":" 1-aminocyclopropane-1-carboxylate synthase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"L-alanine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTATCACTGTCTGCCAAAAATCACTTCACAGTGAGTAATTCTATAACTCACGTTATTAAGTCATATCATATAAGGACTCTCACTTCAAGCGCAGAAAAAATGCCACATATCACTACTCCTTTTTCTACCTCAGCCAGTAGTACAAAGTTAAAAGCTTTCAGGAAAGTTAGACCCGTCCTACAGAGACATAGCTCTTCCTGGATTGTTGCTCAAAATCATAGACGTTCATTATCTGGTCAATCTTCGCTAAACGACCTGCGTCATTTGAATCGCTTTCCACACCACACGTTGAAAACTTCGAATAACGAGTTTTATCCCGCCGAACAATTGACTTTGGAAGACGTAAATGAAAATGTCTTGAAGGCTAAGTACGCCGTTAGAGGTGCCATCCCAATGAGAGCTGAAGAATTGAAAGCTCAACTGGAGAAGGATCCTCAATCTCTGCCATTTGACAGGATTATCAACGCCAATATTGGTAATCCTCAGCAACTACAACAGAAACCTCTGACTTACTACAGACAGGTCTTGTCTCTCTTACAATACCCAGAACTATTAAACCAAAACGAACAGCAGCTAGTTGATTCGAAATTGTTTAAACTAGATGCCATTAAACGTGCAAAGAGTTTAATGGAAGATATCGGTGGTTCTGTTGGTGCTTACTCTTCTTCTCAAGGTGTAGAAGGTATAAGGAAAAGTGTCGCTGAATTTATAACGAAGAGGGACGAAGGCGAGATATCATACCCAGAGGATATTTTCCTAACTGCTGGTGCATCCGCAGCTGTCAATTACTTGTTATCAATTTTCTGTAGAGGGCCAGAAACGGGTGTCTTGATTCCAATTCCTCAATATCCATTATATACCGCTACTCTAGCTTTGAACAATTCTCAAGCTTTACCATACTATTTAGATGAGAATTCAGGTTGGTCAACTAATCCAGAAGAAATTGAAACTGTCGTCAAAGAGGCTATACAGAACGAAATCAAACCTACAGTTCTAGTGGTTATCAATCCAGGTAATCCTACAGGAGCTGTCCTATCACCTGAGTCTATAGCTCAGATTTTTGAAGTCGCAGCCAAGTACGGTACAGTAGTGATAGCTGACGAAGTTTATCAAGAAAATATCTTCCCGGGCACCAAGTTCCATTCTATGAAGAAAATTTTGAGACATTTACAGAGGGAACATCCAGGTAAATTCGATAATGTTCAGCTAGCTTCTTTGCATTCGACTTCTAAGGGTGTTTCTGGTGAATGTGGTCAAAGGGGTGGCTACATGGAACTCACTGGATTCAGCCATGAGATGAGACAAGTTATCTTGAAACTAGCCTCGATTTCATTGTGTCCCGTTGTCACAGGTCAAGCTTTGGTTGATTTGATGGTTCGTCCACCAGTGGAAGGGGAGGAATCATTCGAGTCGGACCAAGCAGAACGTAACTCCATCCATGAAAAGTTAATTACAAGAGCAATGACACTGTATGAGACATTTAACTCTTTAGAAGGCATTGAATGTCAAAAGCCTCAAGGTGCCATGTATTTATTCCCTAAGATAGACTTACCTTTCAAGGCAGTTCAAGAAGCTCGCCACTTAGAGTTAACTCCGGATGAATTTTATTGTAAGAAGTTGTTAGAATCTACTGGCATTTGCACTGTTCCCGGTTCTGGGTTTGGTCAAGAACCTGGTACTTACCATTTAAGAACAACATTTTTGGCACCTGGTCTGGAATGGATTAAGAAATGGGAAAGTTTCCATAAAGAATTTTTTGACCAATACCGTGACTGA","protein_sequence":"MLSLSAKNHFTVSNSITHVIKSYHIRTLTSSAEKMPHITTPFSTSASSTKLKAFRKVRPVLQRHSSSWIVAQNHRRSLSGQSSLNDLRHLNRFPHHTLKTSNNEFYPAEQLTLEDVNENVLKAKYAVRGAIPMRAEELKAQLEKDPQSLPFDRIINANIGNPQQLQQKPLTYYRQVLSLLQYPELLNQNEQQLVDSKLFKLDAIKRAKSLMEDIGGSVGAYSSSQGVEGIRKSVAEFITKRDEGEISYPEDIFLTAGASAAVNYLLSIFCRGPETGVLIPIPQYPLYTATLALNNSQALPYYLDENSGWSTNPEEIETVVKEAIQNEIKPTVLVVINPGNPTGAVLSPESIAQIFEVAAKYGTVVIADEVYQENIFPGTKFHSMKKILRHLQREHPGKFDNVQLASLHSTSKGVSGECGQRGGYMELTGFSHEMRQVILKLASISLCPVVTGQALVDLMVRPPVEGEESFESDQAERNSIHEKLITRAMTLYETFNSLEGIECQKPQGAMYLFPKIDLPFKAVQEARHLELTPDEFYCKKLLESTGICTVPGSGFGQEPGTYHLRTTFLAPGLEWIKKWESFHKEFFDQYRD"},{"created_at":"2011-05-27T02:50:50.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Gamma-glutamyltransferase","uniprot_id":"Q05902","uniprot_name":"ECM38_YEAST","enzyme":true,"transporter":false,"gene_name":"ECM38","num_residues":660,"molecular_weight":"73179.79688","theoretical_pi":"5.72","general_function":"Involved in gamma-glutamyltransferase activity","specific_function":"Plays a role in the turnover of the vacuolar glutathione and in the supply of growth requirements during nitrogen starvation","reactions":[{"id":1557,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2696,"direction":"\u003e","locations":"Vacuole membrane; Single-pass type II membrane protein","altext":"(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.","export":false,"pw_reaction_id":null,"source":null},{"id":3831,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006356","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"14-34","pdb_id":null,"cellular_location":"Vacuole membrane; Single-pass type II membrane protein","genbank_gene_id":"U17243","genbank_protein_id":"596034","gene_card_id":"ECM38","chromosome_location":"chromosome 12","locus":"YLR299W","synonyms":["CIK1 suppressor protein 2","Extracellular mutant protein 38","Gamma-glutamyltranspeptidase","Gamma-GT","Gamma-glutamyltransferase heavy chain","Gamma-glutamyltransferase light chain"],"enzyme_classes":["2.3.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring amino-acyl groups"},{"category":"Function","description":" gamma-glutamyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"G_glu_transpept","identifier":"PF01019"}],"pathways":[{"name":"Taurine and hypotaurine metabolism","kegg_map_id":"00430"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Cyanoamino acid metabolism","kegg_map_id":"00460"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Arachidonic acid metabolism","kegg_map_id":"00590"}],"gene_sequence":"ATGCTGTTGTGTAATAGAAAAGTCCCCAAGACTTTAAATACCTGTTTTATACTGCATATATTCACTCTGTTAACACTGGGTGTGTTAGTGTCCGGAATGCCGTCAAAAATGGTATCATTCGCCTCTCAGGAGACTTTGCAGAGAATAAATAATCTCCTTCGAGGGTCTGCCAATCGAGATGTTGACATTATTGCAGAATATTTGAAAAAAGACGACGATGATGATGGCGGCGATAAGGATCACCATAACATCGATATTGACCCTTTACCTCGCCGTCCTAGTTTAACGCCTGATAGGCAACTTCTAAAAGTCGGTTTGCATGGTGCTATAAGTTCAGATTTAGAAGTCTGTAGTAATTTGACTATAAATGAGGTACTCCTGAAATTTCCCGGTTCTAACGCTGCAGACGCTGCAGTAACACAAGCTCTTTGTAAGGGTATGGTGAATTTTTTTAATAGTGGGATTGGAGGTGGTGGCTACGTAGTTTTTTCTGGCAAAGACGATGAAGATCATCTATCCATTGATTTTAGAGAAAAAGCACCCATGGATTCACATAAGTTCATGTTCGAAAACTGCTCTCTATGCTCAAAAATAGGGGGTCTTGCTGTCGGTGTTCCAGGTGAATTGATGGGTCTCTATCGCCTCTTTAAAGAAAGAGGTAGCGGCCAAGTTGATTGGCGTGATCTAATTGAACCAGTCGCAAAGCTGGGAAGCGTGGGTTGGCAAATAGGCGAAGCACTCGGTGCCACTTTAGAACTTTATGAGGATGTTTTCCTGACATTGAAGGAAGATTGGTCGTTTGTATTGAATTCTACCCATGACGGTGTTTTGAAAGAAGGCGATTGGATCAAGAGGCCGGCACTATCTAACATGCTAATGGAACTGGCTAAAAATGGTTCCGTGGCCCCATTTTATGACCCCGATCACTGGATTGCAAAATCCATGATTGATACTGTCGCAAAATACAATGGAATAATGAACTTGCAGGATGTTTCATCGTATGATGTTCATGTTACTAAACCACTGTCCATGAAAATTAGGAAGGGCGCCAATTTCATCCCTGATAACGATATGACCGTATTAACAAGTAGCGGCTCAAGTTCCGGGGCTGCACTACTTGCGGCGTTAAGGATAATGGATAATTTCCAGAATCAAGAAGGGGGCGATTATGAAAAAGAAACTACCTATCATTTGCTTGAAAGCATGAAATGGATGGCAAGCGCAAGAAGCAGGTTAGGCGATTTTGAAGGCGAAGCATTACCTAAGCATATAGAAGAGGTATTGGATCCAGAATGGGCTTTGAAAGCAGTGAAATCAATCAAAAGAAACTCTCAAGACGGAAATTTTAAAACTTTAGAAAACTGGACGCTTTATGATCCGGCATACGATATCAATAACCCGCATGGAACTGCCCACTTCAGTATAGTAGATTCACATGGGAATGCTGTTTCCTTGACAACCACCATCAACTTGTTGTTCGGTTCCTTAGTACACGACCCAAAAACCGGGGTGATCTTCAATAATGAAATGGACGATTTCGCTCAATTCAACAAATCTAATAGTTTTGAATTGGCACCCTCCATATACAACTTTCCCGAGCCCGGGAAAAGACCCCTATCATCCACTGCACCCACTATTGTGCTGTCAGAATTAGGCATCCCAGACCTCGTGGTCGGCGCTTCCGGCGGCTCAAGAATCACTACGAGTGTTTTACAAACAATTGTGAGGACGTACTGGTATAACATGCCTATATTGGAAACGATAGCCTATCCACGTATACACCACCAGTTACTGCCCGACCGCATAGAACTGGAAAGCTTCCCCATGATCGGTAAAGCCGTACTAAGCACTCTCAAGGAAATGGGATATACGATGAAAGAAGTATTTCCCAAGAGCGTAGTTAATGCTATACGCAATGTCAGGGGAGAATGGCATGCGGTGAGTGACTATTGGAGAAAAAGAGGAATCTCCTCCGTATACTAA","protein_sequence":"MLLCNRKVPKTLNTCFILHIFTLLTLGVLVSGMPSKMVSFASQETLQRINNLLRGSANRDVDIIAEYLKKDDDDDGGDKDHHNIDIDPLPRRPSLTPDRQLLKVGLHGAISSDLEVCSNLTINEVLLKFPGSNAADAAVTQALCKGMVNFFNSGIGGGGYVVFSGKDDEDHLSIDFREKAPMDSHKFMFENCSLCSKIGGLAVGVPGELMGLYRLFKERGSGQVDWRDLIEPVAKLGSVGWQIGEALGATLELYEDVFLTLKEDWSFVLNSTHDGVLKEGDWIKRPALSNMLMELAKNGSVAPFYDPDHWIAKSMIDTVAKYNGIMNLQDVSSYDVHVTKPLSMKIRKGANFIPDNDMTVLTSSGSSSGAALLAALRIMDNFQNQEGGDYEKETTYHLLESMKWMASARSRLGDFEGEALPKHIEEVLDPEWALKAVKSIKRNSQDGNFKTLENWTLYDPAYDINNPHGTAHFSIVDSHGNAVSLTTTINLLFGSLVHDPKTGVIFNNEMDDFAQFNKSNSFELAPSIYNFPEPGKRPLSSTAPTIVLSELGIPDLVVGASGGSRITTSVLQTIVRTYWYNMPILETIAYPRIHHQLLPDRIELESFPMIGKAVLSTLKEMGYTMKEVFPKSVVNAIRNVRGEWHAVSDYWRKRGISSVY"},{"created_at":"2011-05-27T05:45:58.000Z","updated_at":"2011-05-29T05:06:42.000Z","name":"Glutamate decarboxylase","uniprot_id":"Q04792","uniprot_name":"DCE_YEAST","enzyme":true,"transporter":false,"gene_name":"GAD1","num_residues":585,"molecular_weight":"65989.5","theoretical_pi":"6.61","general_function":"Involved in glutamate decarboxylase activity","specific_function":"L-glutamate = 4-aminobutanoate + CO(2)","reactions":[{"id":1571,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2782,"direction":"\u003e","locations":null,"altext":"L-glutamate = 4-aminobutanoate + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3747,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006274","source":"Smpdb"},{"id":3748,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006857","source":"Smpdb"},{"id":3749,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006858","source":"Smpdb"},{"id":14214,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006653","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z48639","genbank_protein_id":"732928","gene_card_id":"GAD1","chromosome_location":"chromosome 13","locus":"YMR250W","synonyms":["GAD"],"enzyme_classes":["4.1.1.15"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" glutamate decarboxylase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamate metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"}],"pfams":[{"name":"Pyridoxal_deC","identifier":"PF00282"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Taurine and hypotaurine metabolism","kegg_map_id":"00430"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Glutamate Metabolism","kegg_map_id":null},{"name":"Taurine and hypotaurine biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTTACACAGGCACGGTTCTAAGCAGAAGAACTTCGAGAATATCGCTGGAAAAGTTGTCCACGACCTTGCAGGTCTGCAATTGCTTTCTAACGACGTTCAAAAATCCGCTGTCCAAAGTGGTCATCAAGGATCGAACAATATGAGAGATACTTCGTCTCAGGGCATGGCTAATAAGTATTCAGTTCCAAAAAAGGGACTACCTGCTGATTTGTCTTACCAACTGATTCATAATGAATTAACACTTGATGGTAATCCGCATTTGAACCTTGCCAGTTTCGTGAACACTTTTACCACTGATCAGGCAAGGAAATTGATTGATGAAAATTTGACCAAAAATCTTGCTGACAATGATGAATATCCGCAATTAATTGAGCTAACTCAGCGTTGTATTTCTATGCTAGCTCAATTATGGCACGCTAATCCCGATGAAGAACCAATAGGCTGTGCCACCACAGGTTCTAGTGAGGCAATCATGTTGGGTGGACTCGCCATGAAAAAAAGATGGGAACACAGAATGAAGAATGCTGGTAAAGATGCTTCCAAGCCGAACATTATAATGTCTTCTGCGTGCCAAGTGGCATTAGAGAAGTTTACGAGATATTTTGAAGTGGAATGCCGATTGGTTCCGGTATCCCACAGAAGCCATCATATGCTTGACCCAGAGTCGTTATGGGATTATGTAGATGAGAACACTATTGGCTGTTTTGTAATTTTAGGAACCACCTACACTGGCCATTTGGAAAATGTAGAGAAAGTTGCAGATGTCTTGTCCCAAATTGAGGCCAAGCATCCTGATTGGAGCAATACTGATATTCCAATCCATGCGGATGGCGCTTCAGGTGGGTTTATTATCCCATTTGGCTTTGAAAAAGAGCACATGAAAGCTTATGGCATGGAACGTTGGGGGTTCAACCATCCGCGTGTGGTTAGTATGAACACTAGTGGTCATAAGTTTGGCTTAACCACTCCCGGTCTGGGTTGGGTGCTATGGAGAGATGAATCCTTACTGGCTGATGAATTGAGATTCAAACTAAAGTACCTCGGTGGCGTGGAAGAAACTTTCGGTTTGAATTTTTCAAGACCTGGATTTCAAGTTGTCCATCAATACTTCAATTTTGTTTCTCTAGGCCATTCAGGGTATAGAACACAATTCCAAAATTCTCTATTTGTTGCAAGAGCGTTTTCTTTCGAATTATTGAATTCGTCAAAATTGCCCGGATGCTTTGAAATTGTTAGCAGTATCCATGAAAGCATTGAGAACGATTCCGCCCCTAAGTCAGTTAAAGACTATTGGGAACACCCCCAGGCTTACAAACCAGGTGTACCGCTGGTAGCCTTCAAATTGTCCAAGAAATTCCACGAAGAATATCCAGAAGTGCCACAAGCAATCCTTTCCTCTTTACTGAGAGGTAGGGGTTGGATAATACCAAATTACCCACTACCAAAGGCAACGGATGGATCCGATGAGAAGGAGGTATTAAGAGTGGTTTTCAGATCGGAGATGAAGTTGGATTTAGCACAGTTGTTGATCGTTGACATCGAGAGTATCTTGACAAAGTTGATTCATAGTTACGAAAAGGTTTGTCATCATATAGAACTTGCCTCTGAGCAAACTCCAGAGCGCAAGAGTTCGTTCATCTACGAAATGTTGCTGGCATTGGCATCTCCACAAGATGACATCCCAACGCCGGATGAAATCGAAAAGAAAAATAAGCTAAAGGAAACAACAACGAGAAACTATAGAGGAACATGTTGA","protein_sequence":"MLHRHGSKQKNFENIAGKVVHDLAGLQLLSNDVQKSAVQSGHQGSNNMRDTSSQGMANKYSVPKKGLPADLSYQLIHNELTLDGNPHLNLASFVNTFTTDQARKLIDENLTKNLADNDEYPQLIELTQRCISMLAQLWHANPDEEPIGCATTGSSEAIMLGGLAMKKRWEHRMKNAGKDASKPNIIMSSACQVALEKFTRYFEVECRLVPVSHRSHHMLDPESLWDYVDENTIGCFVILGTTYTGHLENVEKVADVLSQIEAKHPDWSNTDIPIHADGASGGFIIPFGFEKEHMKAYGMERWGFNHPRVVSMNTSGHKFGLTTPGLGWVLWRDESLLADELRFKLKYLGGVEETFGLNFSRPGFQVVHQYFNFVSLGHSGYRTQFQNSLFVARAFSFELLNSSKLPGCFEIVSSIHESIENDSAPKSVKDYWEHPQAYKPGVPLVAFKLSKKFHEEYPEVPQAILSSLLRGRGWIIPNYPLPKATDGSDEKEVLRVVFRSEMKLDLAQLLIVDIESILTKLIHSYEKVCHHIELASEQTPERKSSFIYEMLLALASPQDDIPTPDEIEKKNKLKETTTRNYRGTC"},{"created_at":"2011-05-27T07:03:07.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Ornithine aminotransferase","uniprot_id":"P07991","uniprot_name":"OAT_YEAST","enzyme":true,"transporter":false,"gene_name":"CAR2","num_residues":424,"molecular_weight":"46085.60156","theoretical_pi":"6.95","general_function":"Involved in transaminase activity","specific_function":"L-ornithine + a 2-oxo acid = L-glutamate 5- semialdehyde + an L-amino acid","reactions":[{"id":1807,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2799,"direction":"\u003e","locations":"Cytoplasm","altext":"L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.","export":false,"pw_reaction_id":null,"source":null},{"id":3741,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006268","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U21094","genbank_protein_id":"665969","gene_card_id":"CAR2","chromosome_location":"chromosome 12","locus":"YLR438W","synonyms":["Ornithine--oxo-acid aminotransferase"],"enzyme_classes":["2.6.1.13"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Aminotran_3","identifier":"PF00202"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCCGAAGCTACCCTCTCCTCCAAGCAAACCATTGAATGGGAAAACAAATACTCCGCCCACAACTACCACCCCTTGCCCGTCGTTTTTCACAAGGCTAAGGGCGCACATGTGTGGGACCCGGAGGGTAAGCTGTACCTCGACTTCCTGAGCGCTTATTCTGCCGTCAACCAGGGCCATTGCCATCCTCACATCATCAAGGCTTTGACGGAGCAAGCACAAACACTAACATTGTCCTCCAGAGCGTTCCACAACGATGTTTACGCGCAATTCGCCAAGTTCGTGACCGAATTCTTCGGGTTCGAAACCGTTTTGCCCATGAACACCGGTGCAGAAGCCGTGGAAACTGCTTTGAAGTTGGCCAGAAGATGGGGGTACATGAAGAAGAACATCCCTCAAGATAAAGCCATCATTCTGGGTGCCGAGGGTAACTTCCACGGGAGAACCTTCGGTGCTATCAGTTTGAGTACCGACTACGAGGACTCCAAGTTGCATTTCGGGCCTTTCGTGCCTAACGTTGCCAGTGGTCACTCCGTGCACAAGATCAGATACGGCCACGCAGAAGATTTCGTCCCTATCTTGGAATCTCCTGAAGGTAAGAACGTTGCCGCCATCATTCTAGAGCCAATTCAGGGTGAAGCCGGTATCGTCGTGCCCCCCGCAGACTACTTCCCAAAGGTCTCCGCATTATGCCGTAAGCACAACGTCCTATTGATCGTTGACGAAATTCAAACCGGTATCGGTAGAACCGGTGAGTTGCTTTGCTACGACCACTACAAGGCAGAGGCCAAGCCTGATATTGTTTTGTTAGGTAAGGCTCTCTCAGGTGGTGTTCTTCCCGTCTCATGTGTTCTGTCTTCTCACGACATCATGTCTTGCTTTACCCCAGGATCTCACGGTTCTACTTTCGGCGGTAATCCTTTGGCTTCCCGCGTTGCCATCGCCGCCCTCGAGGTCATCCGCGACGAGAAGCTGTGCCAAAGAGCCGCCCAACTGGGTAGCTCTTTCATCGCCCAATTGAAAGCTCTCCAAGCCAAATCTAACGGTATAATCTCTGAGGTGCGTGGTATGGGACTGCTTACCGCCATCGTAATCGACCCATCCAAGGCCAATGGTAAGACCGCTTGGGACTTGTGTCTATTGATGAAGGATCACGGCCTCTTGGCTAAGCCCACCCACGACCACATCATCAGATTGGCTCCTCCTTTGGTCATCTCCGAAGAGGACTTGCAAACCGGTGTCGAAACCATTGCCAAGTGTATCGATCTGTTATAA","protein_sequence":"MSEATLSSKQTIEWENKYSAHNYHPLPVVFHKAKGAHVWDPEGKLYLDFLSAYSAVNQGHCHPHIIKALTEQAQTLTLSSRAFHNDVYAQFAKFVTEFFGFETVLPMNTGAEAVETALKLARRWGYMKKNIPQDKAIILGAEGNFHGRTFGAISLSTDYEDSKLHFGPFVPNVASGHSVHKIRYGHAEDFVPILESPEGKNVAAIILEPIQGEAGIVVPPADYFPKVSALCRKHNVLLIVDEIQTGIGRTGELLCYDHYKAEAKPDIVLLGKALSGGVLPVSCVLSSHDIMSCFTPGSHGSTFGGNPLASRVAIAALEVIRDEKLCQRAAQLGSSFIAQLKALQAKSNGIISEVRGMGLLTAIVIDPSKANGKTAWDLCLLMKDHGLLAKPTHDHIIRLAPPLVISEEDLQTGVETIAKCIDLL"},{"created_at":"2011-05-27T07:41:57.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"Mitochondrial aspartate-glutamate transporter AGC1","uniprot_id":"Q12482","uniprot_name":"AGC1_YEAST","enzyme":false,"transporter":true,"gene_name":"AGC1","num_residues":902,"molecular_weight":"104303.0","theoretical_pi":"8.16","general_function":"Involved in binding","specific_function":"Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids","reactions":[],"signal_regions":"None","transmembrane_regions":"534-554;591-611;622-642;681-702;731-751;786-806","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"Z49274","genbank_protein_id":"809586","gene_card_id":"AGC1","chromosome_location":"chromosome 16","locus":"YPR021C","synonyms":["Aspartate-glutamate carrier 1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" organelle inner membrane"},{"category":"Component","description":" mitochondrial inner membrane"},{"category":"Function","description":" binding"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[{"name":"Aspartate metabolism","kegg_map_id":null}],"gene_sequence":"ATGGAGCAAATCAATTCGAACAGTAGAAAAAAGAAGCAACAATTGGAAGTATTCAAATATTTTGCAAGTGTCCTTACAAAAGAGGACAAGCCTATTAGTATCAGTAATGGTATGTTAGATATGCCGACAGTGAACTCCAGTAAACTCACAGCAGGAAATGGGAAACCTGACACGGAGAAGCTTACAGGAGAACTAATTTTAACATACGACGATTTCATTGAACTGATATCTAGCTCAAAGACTATTTATTCGAAGTTTACGGACCATTCGTTCAATTTGAACCAGATACCCAAGAACGTTTTCGGGTGTATTTTCTTCGCTATTGATGAACAAAACAAGGGATATCTGACGCTTAATGATTGGTTTTATTTTAATAATTTATTAGAATATGATAATTATCATCTCATTATTCTATATGAGTTCTTTAGGAAATTTGATGTAGAGAATTTGAAGGCAAAACAAAAAAAAGAGCTTGGTAGTTCGTCGTTTAATTTAAAGGCTGCAGATGATCGAATTAAGTCAATTAATTATGGTAACAGATTTCTAAGCTTTGATGATCTTCTTTTGAATCTGAACCAATTCAAAGATACTATCCGCCTGTTGCACGAATCTATTGATGATAATTTTGTTAAAGATAACAAATTACTACTTGATTGGAATGACTTTCGATTTCTGAAATTTTACAAATGTTATCATGAAAATGAAGAGTATTTGAGTTTAAACTCTCTGGTCACGATTTTACAAAATGATCTTAAGAATGAAAAAATATTTATAGGTTTTGATAGGTTGGCACAGATGGACTCACAAGGGCATCGTTTAGCCCTAAGCAAAAATCAACTCACCTATCTTCTAAGGTTATTTTACTCTCACAGGGTGTCTGCAGATATATTTTCCTCCTTGAATCTATCAAACACCGAATTACTAAAAGCGGACAATAATTCCATTCCGTACAATGTATTCAAGGATATATTTTATTTATTTCAAAATTTTGACCTACTGAACCAAATATTTCACAAGTATGTTACTGAAAATAATTTGAATGAGCAGGATATTAGGGAACAAATAGTTACTAAAAATGACTTTATGACAGTTTTAAACGCCCAGTATAACAAAGTAAACAATATCATTGAGTTCTCTCCTTCCCAAATCAACCTACTATTTTCTATCGTCGCAAATTCAAAGGAAAACAGAAGATTAAGAAAGAGAAATCAAGATCGAGATGACGAGCTATTAAATGATCACCATTATGATTCAGATATTGATTTTTTTATCCATAATGAGTATTTGCATGGAGTAAGCAGATCCAGAAAAAATTTAGAAAGTTTTAATGACTATTATCATGATCTCTCGGATGGATTTGACCAAGACTCTGGTGTTAAAAAAGCTTCAAAAGCGAGTACTGGCTTGTTTGAATCTGTATTTGGAGGTAAAAAAGATAAAGCAACGATGCGTTCTGACTTAACAATTGAAGATTTCATGAAAATTTTGAACCCAAATTACCTGAACGACTTAGTTCACCAAATGGAATTGCAAAAAAATCAAAATGAGTCATTGTATATTAATTACTACTTTTATCCAATTTTCGATTCGTTGTACAATTTCTCCTTGGGTTCTATTGCGGGTTGTATTGGTGCAACTGTAGTATACCCAATAGACTTTATAAAAACAAGGATGCAAGCCCAAAGATCTTTAGCCCAATACAAAAACTCAATTGATTGTTTGTTGAAGATTATATCCCGCGAAGGAATAAAAGGTCTCTACTCTGGCTTAGGGCCACAATTAATAGGAGTTGCTCCTGAAAAGGCGATAAAATTGACTGTCAATGATTTTATGAGAAACAGGTTGACTGATAAAAACGGCAAGCTAAGCCTTTTTCCTGAAATTATTTCTGGCGCTTCAGCTGGTGCATGTCAAGTTATATTTACTAATCCGTTAGAGATTGTAAAAATTAGGCTACAGGTCCAATCCGACTATGTTGGTGAAAACATACAACAAGCCAATGAAACTGCCACTCAAATAGTCAAAAAATTAGGACTGAGGGGCTTGTACAATGGTGTAGCCGCATGTTTAATGAGAGATGTTCCATTCTCTGCTATTTATTTTCCCACTTATGCACATTTAAAAAAAGATCTCTTTGATTTTGATCCAAATGATAAAACAAAGAGGAATCGATTAAAAACATGGGAGCTTTTAACTGCCGGTGCCATTGCTGGTATGCCAGCTGCCTTCTTGACTACTCCTTTTGATGTTATAAAAACAAGGCTCCAGATAGATCCTCGAAAAGGTGAGACAAAGTATAACGGTATATTTCATGCTATCCGAACTATCTTAAAGGAAGAGAGCTTTAGAAGCTTTTTCAAAGGTGGTGGAGCCCGTGTCCTAAGAAGTTCTCCCCAATTTGGGTTCACTCTGGCCGCCTATGAATTATTCAAGGGCTTTATTCCCTCCCCCGATAACAAATTAAAAAGCAGAGAGGGTAGGAAGAGATTTTGTATCGATGACGACGCAGGCAATGAAGAGACAGTAGTTCATAGTAACGGTGAACTCCCACAGCAAAAGTTTTACTCTGATGATAGAAAACATGCCAATTATTACTATAAAAGCTGTCAAATTGCGAAAACATTCATTGATTTGGACAATAACTTTTCTAGGTTTGACTCTTCAGTTTATAAAAACTTTCAAGAGCACCTAAGAAGCATTAACGGGTGA","protein_sequence":"MEQINSNSRKKKQQLEVFKYFASVLTKEDKPISISNGMLDMPTVNSSKLTAGNGKPDTEKLTGELILTYDDFIELISSSKTIYSKFTDHSFNLNQIPKNVFGCIFFAIDEQNKGYLTLNDWFYFNNLLEYDNYHLIILYEFFRKFDVENLKAKQKKELGSSSFNLKAADDRIKSINYGNRFLSFDDLLLNLNQFKDTIRLLHESIDDNFVKDNKLLLDWNDFRFLKFYKCYHENEEYLSLNSLVTILQNDLKNEKIFIGFDRLAQMDSQGHRLALSKNQLTYLLRLFYSHRVSADIFSSLNLSNTELLKADNNSIPYNVFKDIFYLFQNFDLLNQIFHKYVTENNLNEQDIREQIVTKNDFMTVLNAQYNKVNNIIEFSPSQINLLFSIVANSKENRRLRKRNQDRDDELLNDHHYDSDIDFFIHNEYLHGVSRSRKNLESFNDYYHDLSDGFDQDSGVKKASKASTGLFESVFGGKKDKATMRSDLTIEDFMKILNPNYLNDLVHQMELQKNQNESLYINYYFYPIFDSLYNFSLGSIAGCIGATVVYPIDFIKTRMQAQRSLAQYKNSIDCLLKIISREGIKGLYSGLGPQLIGVAPEKAIKLTVNDFMRNRLTDKNGKLSLFPEIISGASAGACQVIFTNPLEIVKIRLQVQSDYVGENIQQANETATQIVKKLGLRGLYNGVAACLMRDVPFSAIYFPTYAHLKKDLFDFDPNDKTKRNRLKTWELLTAGAIAGMPAAFLTTPFDVIKTRLQIDPRKGETKYNGIFHAIRTILKEESFRSFFKGGGARVLRSSPQFGFTLAAYELFKGFIPSPDNKLKSREGRKRFCIDDDAGNEETVVHSNGELPQQKFYSDDRKHANYYYKSCQIAKTFIDLDNNFSRFDSSVYKNFQEHLRSING"},{"created_at":"2011-05-27T08:09:07.000Z","updated_at":"2011-05-27T15:01:29.000Z","name":"Vacuolar amino acid transporter 6","uniprot_id":"P40074","uniprot_name":"AVT6_YEAST","enzyme":false,"transporter":true,"gene_name":"AVT6","num_residues":448,"molecular_weight":"48839.69922","theoretical_pi":"8.92","general_function":"Amino acid transport and metabolism","specific_function":"Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting aspartate and glutamate. 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L-glutamyl-tRNA(Glu).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"GUS1","chromosome_location":"chromosome 7","locus":"YGL245W","synonyms":["Glutamate--tRNA ligase","GluRS","P85"],"enzyme_classes":["6.1.1.17"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside 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