{"ymdb_id":"YMDB00233","created_at":"2011-05-29T16:09:37.000Z","updated_at":"2016-09-08T18:35:13.000Z","name":"L-Glutamic acid 5-phosphate","cas":"13254-53-0","state":"Solid","melting_point":null,"description":"L-Glutamic acid 5-phosphate is an intermediate in the urea cycle and metabolism of amino groups and a substrate of aldehyde dehydrogenase 18 family, member A1 [EC:2.7.2.11 1.2.1.41]. [KEGG]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":"Journal of Heterocyclic Chemistry  (1987),  24(1),  279-82.","chebi_id":"17798","hmdb_id":"HMDB01228","kegg_id":"C03287","pubchem_id":"193475","cs_id":"167893","foodb_id":null,"wikipedia_link":null,"biocyc_id":"L-GLUTAMATE-5-P","iupac":"(2S)-2-amino-5-oxo-5-(phosphonooxy)pentanoic acid","traditional_iupac":"L-gamma-glutamyl phosphate","logp":"-3.0424739962552194","pka":"1.9768584566142886","alogps_solubility":"1.09e+01 g/l","alogps_logp":"-1.96","alogps_logs":"-1.32","acceptor_count":"7","donor_count":"4","rotatable_bond_count":"6","polar_surface_area":"147.15","refractivity":"42.4474","polarizability":"18.089346648683048","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"9.511214443237481","pka_strongest_acidic":"1.1185265364746844","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["L-gamma-glutamyl-5-P","L-gamma-glutamyl-5-phosphate","L-Glutamate 5-phosphate","L-glutamate-5-phosphate","L-Glutamic acid 5-phosphate","L-Glutamic acid 5-phosphic acid","L-glutamyl 5-phosphate","L-glutamyl-5-P"],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Proline Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-26T20:31:54.000Z","updated_at":"2011-05-27T15:01:09.000Z","name":"Glutamate 5-kinase","uniprot_id":"P32264","uniprot_name":"PROB_YEAST","enzyme":true,"transporter":false,"gene_name":"PRO1","num_residues":428,"molecular_weight":"47161.69922","theoretical_pi":"6.75","general_function":"Involved in cellular amino acid biosynthetic process","specific_function":"Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline","reactions":[{"id":1570,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2597,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + L-glutamate = ADP + L-glutamate 5-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3716,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006232","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"M85293","genbank_protein_id":"172241","gene_card_id":"PRO1","chromosome_location":"chromosome 4","locus":"YDR300C","synonyms":["GK","Gamma-glutamyl kinase"],"enzyme_classes":["2.7.2.11"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" phosphotransferase activity, carboxyl group as acceptor"},{"category":"Function","description":" glutamate 5-kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" proline metabolic process"},{"category":"Process","description":" proline biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"}],"pfams":[{"name":"AA_kinase","identifier":"PF00696"},{"name":"PUA","identifier":"PF01472"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Proline Metabolism","kegg_map_id":null}],"gene_sequence":"ATGAAGGATGCTAATGAGAGTAAATCGTATACTATAGTGATCAAATTAGGCTCTTCATCGCTAGTAGATGAAAAAACCAAAGAACCTAAGTTAGCTATCATGTCGCTTATTGTCGAAACTGTAGTCAAATTGAGAAGAATGGGACACAAAGTTATCATCGTGTCCAGTGGTGGTATTGCTGTTGGTTTGAGGACTATGCGTATGAATAAAAGACCAAAACATTTAGCAGAAGTTCAGGCCATCGCAGCTATTGGGCAGGGTAGATTGATCGGGAGATGGGATCTTCTGTTTTCGCAATTTGATCAACGTATCGCTCAAATTCTATTGACCAGAAATGATATTCTGGACTGGACCCAATATAAGAACGCTCAAAACACAATTAATGAATTGTTGAACATGGGCGTTATTCCCATTGTGAATGAAAACGACACACTATCTGTTAGAGAAATCAAATTTGGTGACAATGACACTTTATCAGCAATTACTTCTGCTTTAATCCATGCAGATTATCTTTTCTTACTGACAGATGTTGACTGTTTGTATACTGATAATCCAAGGACAAACCCAGATGCCATGCCGATCTTAGTTGTCCCAGATCTCTCAAAGGGTTTGCCCGGTGTGAATACTGCTGGTGGTTCAGGTTCTGACGTTGGGACCGGTGGTATGGAAACTAAATTGGTTGCTGCAGATTTGGCAACGAATGCCGGTGTTCATACGTTGATCATGAAAAGCGATACACCTGCGAATATAGGTAGAATTGTCGAGTATATGCAAACTCTAGAACTTGACGATGAAAATAAAGTTAAACAAGCATATAATGGCGATTTAACGGATTTGCAAAAAAGAGAATTTGAGAAATTAAAGGCTCTTAACGTTCCACTACATACGAAGTTCATTGCTAATGATAATAAACACCATCTAAAGAATAGAGAGTTTTGGATTTTACACGGTCTTGTCTCTAAAGGCGCTGTTGTTATAGACCAAGGTGCGTACCGAGCCTTAACAAGGAAAAATAAGGCGGGATTATTGCCAGCAGGTGTTATTGATGTTCAGGGCACTTTCCATGAGTTAGAATGTGTTGACATAAAAGTTGGTAAAAAGTTACCAGATGGCACGTTAGATCCAGATTTTCCCTTGCAAACAGTAGGCAAGGCAAGATGCAATTACACGAGTTCTGAATTAACTAAAATTAAAGGTTTGCACAGTGACCAAATCGAAGAGGAATTGGGCTATAATGACAGCGAATATGTCGCTCATAGAGAAAATTTGGCATTCCCACCTCGTTGA","protein_sequence":"MKDANESKSYTIVIKLGSSSLVDEKTKEPKLAIMSLIVETVVKLRRMGHKVIIVSSGGIAVGLRTMRMNKRPKHLAEVQAIAAIGQGRLIGRWDLLFSQFDQRIAQILLTRNDILDWTQYKNAQNTINELLNMGVIPIVNENDTLSVREIKFGDNDTLSAITSALIHADYLFLLTDVDCLYTDNPRTNPDAMPILVVPDLSKGLPGVNTAGGSGSDVGTGGMETKLVAADLATNAGVHTLIMKSDTPANIGRIVEYMQTLELDDENKVKQAYNGDLTDLQKREFEKLKALNVPLHTKFIANDNKHHLKNREFWILHGLVSKGAVVIDQGAYAALTRKNKAGLLPAGVIDVQGTFHELECVDIKVGKKLPDGTLDPDFPLQTVGKARCNYTSSELTKIKGLHSDQIEEELGYNDSEYVAHRENLAFPPR"},{"created_at":"2011-05-27T02:35:18.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Gamma-glutamyl phosphate reductase","uniprot_id":"P54885","uniprot_name":"PROA_YEAST","enzyme":true,"transporter":false,"gene_name":"PRO2","num_residues":456,"molecular_weight":"49740.0","theoretical_pi":"5.25","general_function":"Involved in oxidoreductase activity","specific_function":"Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate","reactions":[{"id":1575,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1576,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2680,"direction":"\u003e","locations":null,"altext":"L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":3717,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006233","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1VLU","cellular_location":null,"genbank_gene_id":"AY692984","genbank_protein_id":"51013419","gene_card_id":"PRO2","chromosome_location":"chromosome 15","locus":"YOR323C","synonyms":["GPR","Glutamate-5-semialdehyde dehydrogenase","GSA dehydrogenase","Glutamyl-gamma-semialdehyde dehydrogenase"],"enzyme_classes":["1.2.1.41"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" NADP or NADPH binding"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" glutamate-5-semialdehyde dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" proline metabolic process"},{"category":"Process","description":" proline biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"}],"pfams":[{"name":"Aldedh","identifier":"PF00171"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Proline Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCCAGTTCACAACAAATAGCCAAAAATGCCCGTAAAGCAGGGAATATTTTGAAAACCATCTCAAACGAGGGCAGATCAGATATTTTATACAAAATTCACGATGCCCTGAAGGCTAATGCGCATGCCATTGAAGAAGCGAATAAAATCGATTTAGCTGTTGCCAAAGAGACTGGCCTAGCGGATTCTTTATTGAAACGTCTCGACCTATTTAAAGGGGACAAATTTGAAGTTATGTTACAAGGTATTAAGGATGTAGCCGAACTAGAAGACCCTGTTGGCAAGGTTAAAATGGCCAGGGAATTAGATGATGGCTTGACGTTGTACCAAGTAACCGCTCCAGTCGGCGTTTTGTTAGTTATCTTTGAATCCCGTCCAGAAGTTATTGCCAATATTACCGCATTGAGTATCAAGTCTGGTAATGCTGCAATTTTGAAGGGTGGTAAAGAGTCTGTGAACACGTTCAGAGAAATGGCAAAGATCGTTAACGACACCATTGCACAATTCCAAAGTGAGACTGGTGTTCCTGTGGGCTCTGTGCAATTGATCGAAACCAGACAGGATGTTTCCGACTTGTTGGATCAAGATGAGTACATCGACTTAGTTGTTCCTCGTGGTTCCAATGCCTTAGTCAGAAAAATCAAGGACACTACAAAAATTCCCGTGTTGGGTCATGCGGATGGTATCTGCTCAATTTACTTGGATGAAGACGCAGATTTGATTAAGGCAAAAAGAATTAGTTTGGATGCAAAGACTAACTACCCAGCTGGTTGCAACGCTATGGAAACGTTGTTGATTAACCCAAAATTCTCTAAGTGGTGGGAAGTTCTGGAAAACTTAACTTTGGAAGGCGGAGTGACTATCCACGCTACAAAAGATTTGAAAACTGCGTATTTTGATAAACTGAATGAGTTAGGGAAATTGACAGAAGCAATTCAATGCAAAACCGTTGATGCTGATGAGGAGCAAGATTTTGATAAGGAATTTTTATCCTTGGATTTGGCTGCCAAGTTTGTTACATCTACAGAATCGGCCATTCAACATATAAATACACACTCTTCGAGACATACCGACGCTATTGTAACGGAAAATAAAGCAAACGCTGAAAAATTTATGAAGGGTGTCGACTCCTCTGGTGTTTACTGGAATGCATCAACTAGATTTGCCGATGGTTTCAGGTACGGTTTTGGTGCTGAAGTGGGTATTTCTACCTCTAAGATTCACGCCCGTGGTCCAGTTGGCTTGGACGGTCTGGTGAGTTATCAATACCAAATAAGAGGTGACGGCCAGGTTGCTAGTGACTACCTTGGTGCTGGTGGTAACAAAGCTTTTGTTCACAAGGATTTAGATATAAAGACTGTGACATTATAA","protein_sequence":"MSSSQQIAKNARKAGNILKTISNEGRSDILYKIHDALKANAHAIEEANKIDLAVAKETGLADSLLKRLDLFKGDKFEVMLQGIKDVAELEDPVGKVKMARELDDGLTLYQVTAPVGVLLVIFESRPEVIANITALSIKSGNAAILKGGKESVNTFREMAKIVNDTIAQFQSETGVPVGSVQLIETRQDVSDLLDQDEYIDLVVPRGSNALVRKIKDTTKIPVLGHADGICSIYLDEDADLIKAKRISLDAKTNYPAGCNAMETLLINPKFSKWWEVLENLTLEGGVTIHATKDLKTAYFDKLNELGKLTEAIQCKTVDADEEQDFDKEFLSLDLAAKFVTSTESAIQHINTHSSRHTDAIVTENKANAEKFMKGVDSSGVYWNASTRFADGFRYGFGAEVGISTSKIHARGPVGLDGLVSYQYQIRGDGQVASDYLGAGGNKAFVHKDLDIKTVTL"}]}