{"ymdb_id":"YMDB00230","created_at":"2011-05-29T16:09:23.000Z","updated_at":"2016-09-08T18:35:12.000Z","name":"1-Phosphatidyl-D-myo-inositol","cas":null,"state":"Solid","melting_point":null,"description":"Phosphatidylinositols are important lipids, both as a key membrane constituent and as a participant in essential metabolic processes, both directly and via a number of metabolites. Phosphatidylinositols are acidic (anionic) phospholipids that consist of a phosphatidic acid backbone, linked via the phosphate group to inositol (hexahydroxycyclohexane). Phosphatidylinositols can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 18 and 20 carbons are the most common. In most organisms, the stereochemical form of the last is myo-D-inositol (with one axial hydroxyl in position 2 with the remainder equatorial. Phosphatidylinositol can be phosphorylated by a number of different kinases that place the phosphate moiety on positions 4 and 5 of the inositol ring, although position 3 can also be phosphorylated by a specific kinase. Seven different isomers are known, but the most important in both quantitative and biological terms are phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Phosphatidylinositol and the phosphatidylinositol phosphates are the main source of diacylglycerols that serve as signaling molecules, via the action of phospholipase C enzymes. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PIs contain almost exclusively stearic acid at carbon 1 and arachidonic acid at carbon 2. PIs composed exclusively of non-phosphorylated inositol exhibit a net charge of -1 at physiological pH. Molecules with phosphorylated inositol (such as PIP, PIP2, PIP3, etc.) are termed polyphosphoinositides. The polyphosphoinositides are important intracellular transducers of signals emanating from the plasma membrane. The synthesis of PI involves CDP-activated 1,2-diacylglycerol condensation with myo-inositol.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cell envelope;mitochondrion;Golgi;endoplasmic reticulum;nucleus;vacuole;cytoplasm","synthesis_reference":null,"chebi_id":"16749","hmdb_id":"HMDB06953","kegg_id":"C01194","pubchem_id":"25245335","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":"1-PHOSPHATIDYL-MYO-INOSITOL","iupac":"[2,3-bis(formyloxy)propoxy]({[(2R,3S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy})phosphinic acid","traditional_iupac":"2,3-bis(formyloxy)propoxy[(2R,3S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphinic acid","logp":"-4.063198509999999","pka":"12.360530531715526","alogps_solubility":"2.70e+01 g/l","alogps_logp":"-1.66","alogps_logs":"-1.16","acceptor_count":"9","donor_count":"6","rotatable_bond_count":"10","polar_surface_area":"209.50999999999996","refractivity":"72.707","polarizability":"32.846154765050215","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-3.6458130204247565","pka_strongest_acidic":"1.833256856862767","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(3-Phosphatidyl)-1-D-inositol","1-Phosphatidyl-1D-myo-inositol","1-Phosphatidyl-myo-inositol","1,2-Diacyl-sn-glycero-3-phosphoinositol","Phosphatidyl-1D-myo-inositol","Phosphatidylinositol"],"pathways":[{"name":"Glycosylphosphatidylinositol(GPI)-anchor biosynthesis","kegg_map_id":"00563"},{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":11514624,"citation":"Foti, M., Audhya, A., Emr, S. D. (2001). \"Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology.\" Mol Biol Cell 12:2396-2411."},{"pubmed_id":12361950,"citation":"Han, G. S., Audhya, A., Markley, D. J., Emr, S. D., Carman, G. M. (2002). \"The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activity.\" J Biol Chem 277:47709-47718."},{"pubmed_id":10900271,"citation":"Taylor, G. S., Maehama, T., Dixon, J. E. (2000). \"Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate.\" Proc Natl Acad Sci U S A 97:8910-8915."},{"pubmed_id":9370330,"citation":"Nikawa, J., Yamashita, S. (1997). \"Phosphatidylinositol synthase from yeast.\" Biochim Biophys Acta 1348:173-178."},{"pubmed_id":17382260,"citation":"Strahl, T., Thorner, J. (2007). \"Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae.\" Biochim Biophys Acta 1771:353-404."},{"pubmed_id":10224048,"citation":"Guo, S., Stolz, L. E., Lemrow, S. M., York, J. D. (1999). \"SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases.\" J Biol Chem 274:12990-12995."}],"proteins":[{"created_at":"2011-05-26T20:14:27.000Z","updated_at":"2011-05-27T15:01:08.000Z","name":"Phosphatidylinositol 4-kinase LSB6","uniprot_id":"P42951","uniprot_name":"LSB6_YEAST","enzyme":true,"transporter":false,"gene_name":"LSB6","num_residues":607,"molecular_weight":"70216.39844","theoretical_pi":"6.68","general_function":"Involved in phosphotransferase activity, alcohol group as acceptor","specific_function":"May play a role in endocytic and/or exocytic pathways","reactions":[{"id":1849,"direction":"\u003c\u003e","locations":"vacuole;Golgi;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2026,"direction":"\u003c\u003e","locations":"vacuole;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2054,"direction":"\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2590,"direction":"\u003e","locations":" Peripheral membrane protein.; Cytoplasmic side.; Peripheral membrane protein;Cell membrane; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein. Vacuole membrane;Nucleus","altext":"ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cell membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.","genbank_gene_id":"X85021","genbank_protein_id":"728710","gene_card_id":"LSB6","chromosome_location":"chromosome 10","locus":"YJL100W","synonyms":["PI4-kinase","PtdIns-4-kinase","LAS seventeen-binding protein 6","LAS17-binding protein 6"],"enzyme_classes":["2.7.1.67"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PI3_PI4_kinase","identifier":"PF00454"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"}],"gene_sequence":"ATGAGTAACGAAGCTTACCAGCATGATCATACCGTAAATCCTCACCAGAAGATAGTTGTGAACAGCTACGATTGGTTACAGTTCCGTGATGAGCAAGATCACTGTAAAAGTAAGAACCCGATAACGCACGCTTCTCCAGGGGTCGGTTCGAATGCACAGAATTCAGACATAGCGGAGGCCCCTCAGGTATTCCACCCTTCCTATCAATCTCTGGTCAACGTACCGTCCGAGAGCCCGCGACCTGATCAGACTTCAGGGTCCAATCCTGCCGTTGGACTGCTTCATAATGCAGAGGACAAAGCGTCAGGGCAAGAAGAAGAAGGAAGTCAATATGAGATTCAATATTCGGTATTTCGTCCGCTGCATGCATATCCAACCAAGGGCCTAGCATATGAGCAGCTCCGAAGAAAAGAAGAACAAGAACAGAGGGAAAACTTCAACCATTTGGTTTCTGACTGTATTGAGGCTGTAGAGACATTTGGACGCGAACTCGAGAGAATCCAAACTGGCTCAAGTGGGTCGTACTTTGTGTATGGAACACGGGCCGACGAAAGCGTTCCGGTGGGGGTCTTCAAGCCCAAGGATGAGGAACCATATGGCCCATTTTCTCCCAAATGGACCAAATGGGCACACCGCACGTTTTTCCCATGTCTGTTTGGCAGAAGTTGTCTGATTCCAAACCTCGGGTACATCTGTGAAAGTGCGGCTAGTTTGTTGGATAGGCGACTGGAAACGCATCTAGTACCCTATACAGATACTGCATCTATAGAGTCTTTTAATTTTTATGATAATAGAAAAAAATGGGTATTGGGATACAACCTTCAGAAGAAGAAACAAAAAAAGCTGGGTTCTTTCCAACTTTTTTTGAAGGAGTACATCAACGCCGATGAGTTCTTTCATAAATACCCATTACCTGGGATGTATTCAGATGTTAAACATTCATTTCATCGTAAGTCATCCGGCGAAGATATCAATCATAAACCAGAGACAACCAGGAACCTAACAGATGAGACAGAACCGTCCAAGCAAATAAATTCCTCTCCAATTTCGACGGAATCTGAAGAAAATTCGAAATTTGAATGGACAGAATCAAGTTTGAGTCAGTTCAGATTGGAACTAGAAAAACTAATTATCCTTGATTATATAATGAGAAACACAGATAGAGGTCTAGACAATTGGATGGTGAAACTAATCAAACTTTCAAACAATAAGTGGAGACTCAAGTTAGCCGCCATCGACAATGGGTTGTCCTTTCCCTGGAAGCATCCTGATGAGTGGCGTCTGTACCCATATGGCTGGTTGTATTTGCCTCTGCAACTACTAGCCAAACCATTTTCTGAGCAAATGAGATCTCATTTCCTACCGATATTGACAAGCACTAATTGGTGGGAAGAGTCGTACCAAGAATTCTTGGCCCTATTTAGCAGGGACCAAGATTTTAACGTCCGAATGTGGAAGAAGCAATGGGCAGTATTAAAAGGACAGGCGTTCAACGTTGTCGAAACATTGAAAGACCCACGACAAGGCCCCTTGGAATTGGTTAGAAGGACAAGGTGCCAGGTAATAGATGAGAAGATGCAAGTTCCCTGTTGCCCACCTCCAGTTTCTATTTTCAAAAACGCCATAGACGAACCTATTGGATCATATTCCACTTCACCAATGGTACTCCCTAGCACCCCAAGCACAATTCCATTTCATGCACATAACCAAAGCAATAGTAATCCTGTATACTATGATTCCACTCTGCACCCATTTGCTAATAAAACAGTGATAGCAGAGCGGCTACAAATAGTCAATTCCACCCCCGTATTCACCTGGTGTTGA","protein_sequence":"MSNEAYQHDHTVNPHQKIVVNSYDWLQFRDEQDHCKSKNPITHASPGVGSNAQNSDIAEAPQVFHPSYQSLVNVPSESPRPDQTSGSNPAVGLLHNAEDKASGQEEEGSQYEIQYSVFRPLHAYPTKGLAYEQLRRKEEQEQRENFNHLVSDCIEAVETFGRELERIQTGSSGSYFVYGTRADESVPVGVFKPKDEEPYGPFSPKWTKWAHRTFFPCLFGRSCLIPNLGYICESAASLLDRRLETHLVPYTDTASIESFNFYDNRKKWVLGYNLQKKKQKKLGSFQLFLKEYINADEFFHKYPLPGMYSDVKHSFHRKSSGEDINHKPETTRNLTDETEPSKQINSSPISTESEENSKFEWTESSLSQFRLELEKLIILDYIMRNTDRGLDNWMVKLIKLSNNKWRLKLAAIDNGLSFPWKHPDEWRLYPYGWLYLPLQLLAKPFSEQMRSHFLPILTSTNWWEESYQEFLALFSRDQDFNVRMWKKQWAVLKGQAFNVVETLKDPRQGPLELVRRTRCQVIDEKMQVPCCPPPVSIFKNAIDEPIGSYSTSPMVLPSTPSTIPFHAHNQSNSNPVYYDSTLHPFANKTVIAERLQIVNSTPVFTWC"},{"created_at":"2011-05-26T21:20:36.000Z","updated_at":"2011-05-27T15:01:10.000Z","name":"Phosphatidylinositol 4-kinase STT4","uniprot_id":"P37297","uniprot_name":"STT4_YEAST","enzyme":true,"transporter":false,"gene_name":"STT4","num_residues":1900,"molecular_weight":"214605.0","theoretical_pi":"7.51","general_function":"Involved in binding","specific_function":"Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. STT4 functions in PKC1 protein kinase pathway","reactions":[{"id":2054,"direction":"\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2590,"direction":"\u003e","locations":" Peripheral membrane protein.; Cytoplasmic side.; Peripheral membrane protein;Cell membrane; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein. Vacuole membrane;Nucleus","altext":"ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":34400,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R026916","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D13717","genbank_protein_id":"454207","gene_card_id":"STT4","chromosome_location":"chromosome 12","locus":"YLR305C","synonyms":["PI4-kinase","PtdIns-4-kinase"],"enzyme_classes":["2.7.1.67"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" intracellular signal transduction"},{"category":"Process","description":" second-messenger-mediated signaling"},{"category":"Process","description":" phosphoinositide-mediated signaling"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphoinositide metabolic process"},{"category":"Process","description":" phosphoinositide phosphorylation"},{"category":"Process","description":" biological regulation"}],"pfams":[{"name":"PI3_PI4_kinase","identifier":"PF00454"},{"name":"PI3Ka","identifier":"PF00613"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Stress-activated signalling pathways: cell wall stress test 1","kegg_map_id":null}],"gene_sequence":"ATGAGATTTACCAGAGGATTGAAAGCCTCTTCATCTTTAAGAGCGAAAGCTATTGGAAGACTAACTAAACTTTCGACGGGTGCACCAAATGATCAAAACAGTAATGGTACAACATTAGATTTGATAACTCATACATTGCCTATTTTTTATTCCACAAATACGTCAAAGATATATACTATACCACTTACATTGAGTGAATGGGAAGTACTAACTTCGCTTTGTGTTGCAATCCCTACCACGCTCGATCTGGTAGAGACAATGCTTAAAGAAATAATTGCGCCTTATTTTCTGGAAACTCCAAGACAAAGAATTTCAGATGTTCTGTCCTCGAAATTCAAGTTGGAACAGATGAGAAATCCGATTGAATTGCTAACTTTCCAGCTGACTAAGTTTATGATTCAAGCTTGTGAACAGTATCCCGTTCTTTATGAAAATATAGGCGGCATCATTTCAACTTATTTTGAGCGTGTATTAAAGATTTTTACTATTAAACAATCTGGTCTACTATCATTAGTGGGCTTTATTAATGCATTTATCCAGTTTCCCAACTCTACAGAGCTTACTAAATTCACCTGGAAAAAGTTAGCGAAACTTGTGCTTCGTGGATCATTTCTAAACGAAGTTGATAAGATTTTGAATTCCTCAGCAACGTTTACCAATGATTCAATCGTCCAGTATTACGATGCTGGAAATGAGCTATCCAGTGCCTACTTATTGGAATTAATATCTCGCTTGCAAGTTTCGCTAATATCTCATCTGTTAAACACTTCACATGTCGGCGCCAACTTGAGTGAGTTCTTACTAAATCAACAATACCAATTTTACAAATTTGATCAAGAAGTAGCCGATGAAAACGATGATACGAAGTGTATTGATGACTTTTTTTTCAACGTAAGAAGCAATAAACAGTTTTTTACAGACATGTGTAAAATTTCCCTGCAATTTTGTTCTGAGTCACATATTCTCGACCTATCTACAGACAACCGTGCAAGATTTTCTTTTGATACTCGAGCCCACTACCTACAAACGCTATGTTTAATTCCGTTTATAGAAGATACAGAAAGCGAGCTTTTTGAAAGTTTTACAAACGTTGTTTCTGAATCTATTGATAAATTTTTCTTATCTGATGTCGTTACACCATCTTTGATAAAAGCAATTGTAGCTTCTGCCTCATTACTGAATTTTTTCACGGAAAAATTGTCATTAACTCTGATTCGTATGTTTCCTTTATTGGTAGCGTCTCCACATATCACGACTGAAACAGTTAATGATGTTGCAAAAATATTCACCACAGGGTTATACCCTCTAAATGAAGATGCAATTGTGAGTACAATTTATTCCATGAACAACTTATTAGCTGTTTCCGAGGACGGATCGCCCGTCCCGGTGCTCCGTGAGCGCCAATTAACAATAACATCTGGAAAAAATATTGAGAAAGACTACTTTCCCTTGCGAAATTCATCTGCCAGTTTGGATGGCACTGGTGCTCTGCTCGGAAATACAACTGTGGGCCAACTTTCCTCCCATGATGTCAATAGTGGAGCTACTATGACATACCATGCCTCTTTGATATCTAATTGTGTGGCTGCAACGACTACAATCGCCTCATACTATAACACCCAAAGCATAACAGCTTTGACTATCTCTATTCTTACGCAAAAAGTTAATTCTATGTCAAAGGAATTAGACGGTGTTATTTTGAATTCTTTGGCAAGACTGGCTCCGAATACTTCACTGACAGAATTTTCGCTTTTACTAAAGTTCTTCAAATCGAGAACTGTTATTGCAACAAAAATTGATGATAGCGCACTATTGAAAAATATTATTAAAGCGAAATGTGTGATATCAAAAGAATTGTTGGCCAGGCATTTTTCAAGTGACTTATATTTCATGTATCTTCATGATCTATTGGACTCAATTATTGCCAGTGGGGAAGTAGAACGATTGGAACATCACAGACCTCAAACGGAGATTTCCCGTGTTGCTGATCAAATCGCTACCTACTTAGAGCCCCTCGCCGCTCTACTACCTGTTCCAGGCGATACGCCATTGGACATCAATAAGGATGAAGTCACTACAAACAAGTTTAGGAACGCCTGGTTTAATTTTGTCATCCATGGGTACCACTTGGGCGGGCCTATTGTCAAACGAAATTTTTCTTTCTTATTAACTATTGCCTATAATTCACCACCGCTGGCTTCTGAATTTCCTGCTAATAACAAGGAGCTTTCATTGGAAATGAATACAATTTTGCGCCGCGGTTCATCTAACGAAAATATCAAACAACAAAAACAGCAGATAACCGAATATTTCAATACCAATATTGTTCAGTACAGAACAACTTCATCGTCTAAAATCATGTTTTTAGCGGCTGCCGTTCTTCTAGAAACGATAAGATGCGAGGCAGGTGATTGTTCGAAGACTCTACTGTACTTCTCAGACCCCTCCATTCTTTCCGGTTCAATTGAGAAGTGTATTGCAGTTTTGTCGGTTTCCATGATTAGAAAATATGCTAGGTTGATTCAAAAGGGTAACGATGCCATATTCAACTCCAAAATGATTGCTCAACAACTTAATAACTTGCTACTTTGCCTTTCTCATAGGGAACCAACTTTGCAGGATGCCGCTTTTCATGCCTGTGAAATATTTATCAGATCTATTCCATCATCGTTATGTCATCATTTGTCTCTCTACACCTTATTAGATATGTTAACAGCCCTATTTGATAGTATCTTGGACTCAGAGGCGCATAAATTTGAACCACGGTATGAATTTAAATTAAAACATTCTAAGACAACAATATTGGTTCCAAGCTCATCGTCCTGGCGCGCTACGACACTATCAAGATTGCACAAGTCAGCTAAAGAATGGGTAAGAATTCTATTGAATAGAAGCAACCAGGATACTAAGATTTTGTTGCAATCATACATATCAGATCTCGGTGAGTACAGCAGGCTAAATTCTGTTGAATTTGGTGTCTCATTTGCCATGGATATGGCTGGTTTGATTTTACCTGCAGATAAGGAATTATCAAGGCTTACTTATTATGGTCCAGAGAAACCTAACACGATTTCTGGATTTATATCTTTACATTCTTGGAGGTCAAAATATCTTTTCGATACCGCTATTACATCATCACCAGAGGATATCAAAAGGCAAATAGGTATTTCCACTCAAAACATAAGAAAAAATTTGACCTTAGGAAATAAGATTATAACTAAAGACGTAACTGATTTTCTTGATATGGCTACCGCGTTGTTAATTCTTGGCAATGGTGCACCAGCGTCATTGATATATGATATTGTGCACATCCCGTTCGAAGTCTTCACCTCTGCATCTTTAAAGATTGCTACAAACGTATGGTTAACAATCATAACTGAGAAGCCCGAAGTTGCACATTTGCTTTTAGTTGAAGTATGCTATTGCTGGATGCGCTCCATTGATGACAATATTGGTCTCTATTCTCGCGATCATGACTTAAAGGGCGAAGAATACCAAAAAATGGAATATTCCCCTTACGACAAAGCAGGTATCAACAGAGATGCAAAAAATGCATCCCAAGCTATGCAACCACATCTTCATGTTATTAAATTTTTTGCTTCCCATTTCGAGGGCACACTATTTCAAAGTGACTTTTTATTGAAAATTTTCACGAAATGTGCGCTTTATGGTATCAAGAATCTGTATAAGGCTTCACTACACCCGTTCGCTAGAATGATTCGCCACGAATTATTGTTATTCGCGACTCTCGTACTAAACGCAAGTTATAAGCAGGGATCCAAGTATATGGGCCGTTTGTCGCAAGAAATCACAAACGGTGCCCTAAGTTGGTTTAAAAGACCAGTAGCGTGGCCATTCGGCTCAAATGAGCTGAAAATCAAAGCAGATTTATCTGTTACTAGGGACCTTTTCCTTCAGCTCAACAAATTAAGCTCGCTAATGTCACGTCATTGCGGGAAAGATTACAAGATCCTGAACTATTTCTTGGCAAGCGAAATCCAGCAGATTCAAACCTGGCTTACTCCGACTGAGAAGATTGAAGGAGCCGACAGCAACGAGCTTACAAGCGATATCGTTGAAGCTACCTTTGCTAAAGATCCAACATTAGCAATAAATCTCTTACAACGATGTTATAGCAAGAAAGCTGAGGATGTTTTAGTGGGCTTAGTTGCAAAACATGCTTTAATGTGTGTGGGGTCCCCAAGTGCTCTTGACCTGTTCATAAAAGGAAGCCACCTGAGCAGTAAGAAAGACCTACACGCAACCTTATACTGGGCGCCAGTGAGCCCGTTAAAATCTATCAACCTTTTCCTTCCCGAATGGCAAGGTAATTCTTTTATCTTACAATTCAGCATATATTCGTTGGAATCACAAGATGTGAACTTGGCATTCTTCTATGTTCCTCAAATCGTACAATGTTTGAGATACGATAAAACCGGATATGTCGAAAGATTGATTTTGGATACTGCGAAAATTAGTGTGTTATTTTCTCATCAAATAATCTGGAATATGCTTGCAAACTGCTACAAGGATGATGAAGGTATACAAGAAGATGAAATCAAACCAACTCTAGATCGTATTAGGGAGCGTATGGTTTCAAGTTTCAGCCAATCTCATCGCGATTTTTACGAACGTGAATTTGAATTCTTCGACGAAGTAACTGGCATATCTGGTAAGTTGAAACCATACATAAAAAAAAGTAAGGCTGAAAAGAAACATAAGATCGATGAAGAAATGAGCAAAATTGAGGTGAAACCTGATGTTTATTTACCTTCTAATCCTGACGGTGTAGTTATTGATATTGATCGGAAGAGTGGTAAGCCACTTCAATCTCACGCAAAGGCGCCTTTTATGGCGACCTTTAAAATAAAGAAAGACGTAAAAGATCCTTTGACAGGTAAAAACAAGGAAGTTGAAAAATGGCAAGCTGCTATCTTCAAAGTCGGTGATGACTGTAGGCAAGATGTTCTAGCGTTACAATTGATCTCGCTATTTAGAACCATTTGGTCTAGTATTGGCTTGGATGTCTACGTTTTTCCCTACAGAGTTACTGCGACGGCACCGGGTTGTGGTGTCATCGATGTGCTACCCAATTCGGTATCCCGTGATATGTTAGGACGTGAAGCTGTTAATGGATTATATGAATATTTCACTAGTAAATTTGGTAATGAATCTACTATCGAATTTCAAAACGCACGAAACAACTTTGTTAAATCCTTAGCGGGATATAGCGTAATTTCGTATTTGTTGCAATTCAAGGATAGACATAATGGTAACATTATGTACGATGATCAAGGACATTGTCTACATATCGATTTTGGGTTTATTTTTGATATTGTCCCAGGTGGTATCAAGTTTGAAGCAGTACCATTCAAGCTGACGAAAGAAATGGTTAAAGTGATGGGAGGTTCGCCCCAGACCCCAGCGTATCTGGACTTTGAAGAACTTTGTATCAAGGCATATCTAGCCGCCCGTCCGCACGTGGAGGCCATAATTGAGTGTGTAAATCCTATGTTAGGAAGCGGTCTCCCCTGCTTTAAGGGTCACAAGACAATTAGGAATCTAAGAGCAAGATTTCAACCTCAAAAAACCGATCACGAAGCTGCACTATATATGAAGGCGCTAATCCGTAAAAGTTATGAAAGTATATTCACTAAAGGTTATGATGAATTCCAAAGGCTCACAAATGGCATTCCGTACTGA","protein_sequence":"MRFTRGLKASSSLRAKAIGRLTKLSTGAPNDQNSNGTTLDLITHTLPIFYSTNTSKIYTIPLTLSEWEVLTSLCVAIPTTLDLVETMLKEIIAPYFLETPRQRISDVLSSKFKLEQMRNPIELLTFQLTKFMIQACEQYPVLYENIGGIISTYFERVLKIFTIKQSGLLSLVGFINAFIQFPNSTELTKFTWKKLAKLVLRGSFLNEVDKILNSSATFTNDSIVQYYDAGNELSSAYLLELISRLQVSLISHLLNTSHVGANLSEFLLNQQYQFYKFDQEVADENDDTKCIDDFFFNVRSNKQFFTDMCKISLQFCSESHILDLSTDNRARFSFDTRAHYLQTLCLIPFIEDTESELFESFTNVVSESIDKFFLSDVVTPSLIKAIVASASLLNFFTEKLSLTLIRMFPLLVASPHITTETVNDVAKIFTTGLYPLNEDAIVSTIYSMNNLLAVSEDGSPVPVLRERQLTITSGKNIEKDYFPLRNSSASLDGTGALLGNTTVGQLSSHDVNSGATMTYHASLISNCVAATTTIASYYNTQSITALTISILTQKVNSMSKELDGVILNSLARLAPNTSLTEFSLLLKFFKSRTVIATKIDDSALLKNIIKAKCVISKELLARHFSSDLYFMYLHDLLDSIIASGEVERLEHHRPQTEISRVADQIATYLEPLAALLPVPGDTPLDINKDEVTTNKFRNAWFNFVIHGYHLGGPIVKRNFSFLLTIAYNSPPLASEFPANNKELSLEMNTILRRGSSNENIKQQKQQITEYFNTNIVQYRTTSSSKIMFLAAAVLLETIRCEAGDCSKTLLYFSDPSILSGSIEKCIAVLSVSMIRKYARLIQKGNDAIFNSKMIAQQLNNLLLCLSHREPTLQDAAFHACEIFIRSIPSSLCHHLSLYTLLDMLTALFDSILDSEAHKFEPRYEFKLKHSKTTILVPSSSSWRATTLSRLHKSAKEWVRILLNRSNQDTKILLQSYISDLGEYSRLNSVEFGVSFAMDMAGLILPADKELSRLTYYGPEKPNTISGFISLHSWRSKYLFDTAITSSPEDIKRQIGISTQNIRKNLTLGNKIITKDVTDFLDMATALLILGNGAPASLIYDIVHIPFEVFTSASLKIATNVWLTIITEKPEVAHLLLVEVCYCWMRSIDDNIGLYSRDHDLKGEEYQKMEYSPYDKAGINRDAKNASQAMQPHLHVIKFFASHFEGTLFQSDFLLKIFTKCALYGIKNLYKASLHPFARMIRHELLLFATLVLNASYKQGSKYMGRLSQEITNGALSWFKRPVAWPFGSNELKIKADLSVTRDLFLQLNKLSSLMSRHCGKDYKILNYFLASEIQQIQTWLTPTEKIEGADSNELTSDIVEATFAKDPTLAINLLQRCYSKKAEDVLVGLVAKHALMCVGSPSALDLFIKGSHLSSKKDLHATLYWAPVSPLKSINLFLPEWQGNSFILQFSIYSLESQDVNLAFFYVPQIVQCLRYDKTGYVERLILDTAKISVLFSHQIIWNMLANCYKDDEGIQEDEIKPTLDRIRERMVSSFSQSHRDFYEREFEFFDEVTGISGKLKPYIKKSKAEKKHKIDEEMSKIEVKPDVYLPSNPDGVVIDIDRKSGKPLQSHAKAPFMATFKIKKDVKDPLTGKNKEVEKWQAAIFKVGDDCRQDVLALQLISLFRTIWSSIGLDVYVFPYRVTATAPGCGVIDVLPNSVSRDMLGREAVNGLYEYFTSKFGNESTIEFQNARNNFVKSLAGYSVISYLLQFKDRHNGNIMYDDQGHCLHIDFGFIFDIVPGGIKFEAVPFKLTKEMVKVMGGSPQTPAYLDFEELCIKAYLAARPHVEAIIECVNPMLGSGLPCFKGHKTIRNLRARFQPQKTDHEAALYMKALIRKSYESIFTKGYDEFQRLTNGIPY"},{"created_at":"2011-05-27T00:26:08.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Phosphatidylinositol 3-kinase VPS34","uniprot_id":"P22543","uniprot_name":"VPS34_YEAST","enzyme":true,"transporter":false,"gene_name":"VPS34","num_residues":875,"molecular_weight":"100920.0","theoretical_pi":"7.9","general_function":"Involved in binding","specific_function":"Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy- specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3- kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Its activation by VPS15 may lead to the phosphorylation of phosphatidylinositol in the sorting compartment membrane. Finally, it might also be involved in ethanol tolerance and cell wall integrity","reactions":[{"id":1897,"direction":"\u003e","locations":"vacuole;vacuolar membrane","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2619,"direction":"\u003e","locations":"Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein","altext":"ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14857,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007045","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein","genbank_gene_id":"U20865","genbank_protein_id":"662340","gene_card_id":"VPS34","chromosome_location":"chromosome 12","locus":"YLR240W","synonyms":["PI3-kinase VPS34","PI3K VPS34","PtdIns-3-kinase VPS34","Carboxypeptidase Y-deficient protein 15","Vacuolar protein sorting-associated protein 34","Vacuolar protein-targeting protein 29"],"enzyme_classes":["2.7.1.137"],"go_classes":[{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Component","description":" phosphoinositide 3-kinase complex"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" lipid kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" phosphoinositide 3-kinase activity"},{"category":"Function","description":" 1-phosphatidylinositol-3-kinase activity"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" intracellular signal transduction"},{"category":"Process","description":" second-messenger-mediated signaling"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" phosphoinositide-mediated signaling"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphoinositide metabolic process"},{"category":"Process","description":" phosphoinositide phosphorylation"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" regulation of biological process"}],"pfams":[{"name":"PI3_PI4_kinase","identifier":"PF00454"},{"name":"PI3Ka","identifier":"PF00613"},{"name":"PI3K_C2","identifier":"PF00792"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCACTGAACAACATAACATTCTGTGTCTCACAGGATCTGGATGTTCCCCTGAAAGTGAAAATCAAGTCATTGGAAGGACATAAGCCACTGTTGAAGCCATCTCAAAAAATCCTGAACCCTGAATTAATGCTGATAGGGTCAAATGTATTCCCTTCTAGTGATCTAATTGTATCCTTACAGGTATTTGATAAAGAGAGAAACAGAAATTTAACTCTTCCGATATACACGCCGTATATTCCTTTCAGAAACTCTAGAACCTGGGATTATTGGTTGACTTTGCCCATACGTATCAAACAGCTTACCTTTAGCAGTCATTTACGCATTATTTTGTGGGAATACAATGGATCCAAGCAAATTCCCTTTTTCAATCTAGAAACGAGCATCTTTAACTTAAAAGACTGTACTTTAAAAAGAGGGTTTGAATCCTTAAAATTTCGTTATGATGTGATTGACCACTGTGAAGTGGTCACTGATAACAAAGATCAAGAAAATTTGAATAAATATTTTCAGGGTGAATTCACGAGACTCCCTTGGCTTGACGAAATCACTATAAGCAAATTAAGGAAACAACGGGAAAATAGGACTTGGCCTCAGGGCACCTTTGTCTTAAACTTAGAATTTCCAATGTTAGAGCTTCCTGTTGTGTTCATCGAAAGGGAAATTATGAATACTCAAATGAATATTCCAACTTTGAAGAACAATCCTGGACTAAGCACAGACTTACGAGAACCGAATAGGAATGATCCTCAAATCAAAATTTCTTTGGGGGACAAATATCACTCCACATTGAAGTTTTACGATCCTGACCAACCAAACAATGATCCAATAGAGGAAAAGTATAGGAGATTGGAAAGAGCATCTAAAAATGCAAACTTGGACAAGCAAGTGAAGCCGGACATTAAAAAGAGGGACTACTTGAATAAAATCATCAACTACCCCCCTGGCACTAAATTAACAGCACATGAAAAGGGTTCAATATGGAAATATAGGTATTATTTGATGAACAATAAAAAAGCTCTTACAAAGTTATTACAGAGTACAAATTTGAGAGAAGAATCGGAAAGAGTAGAGGTTTTAGAACTAATGGACTCATGGGCAGAAATTGATATAGACGACGCATTAGAACTATTAGGCTCAACTTTTAAAAACCTTTCAGTGAGATCGTACGCCGTAAATAGGCTGAAGAAGGCATCAGACAAGGAGCTGGAATTGTACTTATTACAGTTGGTAGAAGCTGTCTGTTTTGAGAACCTGTCCACTTTTTCCGACAAATCTAACAGTGAATTCACTATTGTGGATGCCGTATCTTCGCAAAAGCTTTCGGGTGATTCTATGTTACTATCTACATCGCATGCCAACCAAAAATTATTAAAGTCCATCTCGAGTGAATCGGAAACTTCCGGGACAGAATCGCTACCAATCGTCATTTCTCCCTTGGCTGAGTTTTTGATTAGGAGAGCACTGGTCAACCCAAGGTTAGGAAGTTTTTTCTATTGGTATTTAAAGTCCGAGTCTGAGGACAAGCCATATTTAGACCAGATTTTAAGTTCCTTTTGGAGTAGACTGGATAAAAAATCTCGGAATATACTGAACGATCAAGTCAGGCTAATAAATGTGCTCAGGGAATGTTGTGAAACAATTAAGAGGCTGAAAGATACTACAGCCAAAAAGATGGAATTACTAGTGCATTTATTGGAGACGAAAGTCAGGCCTCTTGTCAAAGTACGACCAATTGCTTTACCACTAGACCCTGATGTGTTGATATGCGACGTTTGTCCTGAAACTTCGAAGGTATTTAAAAGCTCTTTATCGCCACTAAAAATAACATTCAAAACGACCTTAAACCAACCATATCACTTAATGTTTAAGGTTGGCGATGATTTGAGACAAGATCAACTGGTAGTACAGATCATAAGTTTAATGAATGAGTTATTAAAAAATGAAAACGTGGACTTGAAATTGACACCATACAAAATTTTGGCAACAGGACCACAAGAAGGTGCCATTGAATTTATCCCTAATGACACATTAGCTAGCATACTAAGCAAATATCACGGTATTCTTGGCTACCTTAAACTCCACTATCCTGATGAGAACGCGACATTAGGCGTACAAGGCTGGGTTTTAGATAATTTTGTCAAATCTTGTGCTGGCTATTGTGTTATTACATACATCTTAGGTGTCGGCGATAGGCATTTAGACAACTTACTAGTCACGCCAGATGGGCACTTTTTTCACGCAGACTTTGGTTATATCTTGGGTCAGGACCCCAAACCTTTTCCGCCATTAATGAAATTGCCCCCTCAAATTATAGAGGCGTTTGGGGGTGCAGAATCATCAAATTATGATAAATTTCGCAGCTACTGTTTTGTGGCATATTCGATTTTAAGAAGGAATGCAGGCTTAATCTTAAACCTGTTTGAATTAATGAAGACTTCGAACATACCTGATATCAGAATAGATCCCAATGGTGCTATATTACGTGTAAGAGAGAGATTTAATTTGAATATGTCCGAAGAAGATGCCACAGTGCATTTTCAGAATCTAATCAATGATAGTGTAAATGCTTTGCTGCCTATCGTGATTGATCATTTACATAATCTGGCACAATACTGGCGGACCTGA","protein_sequence":"MSLNNITFCVSQDLDVPLKVKIKSLEGHKPLLKPSQKILNPELMLIGSNVFPSSDLIVSLQVFDKERNRNLTLPIYTPYIPFRNSRTWDYWLTLPIRIKQLTFSSHLRIILWEYNGSKQIPFFNLETSIFNLKDCTLKRGFESLKFRYDVIDHCEVVTDNKDQENLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVFIEREIMNTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLERASKNANLDKQVKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMNNKKALTKLLQSTNLREESERVEVLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSRNILNDQVRLINVLRECCETIKRLKDTTAKKMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPNDTLASILSKYHGILGYLKLHYPDENATLGVQGWVLDNFVKSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKPFPPLMKLPPQIIEAFGGAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNLNMSEEDATVHFQNLINDSVNALLPIVIDHLHNLAQYWRT"},{"created_at":"2011-05-27T00:43:23.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Phosphatidylinositol 4-kinase PIK1","uniprot_id":"P39104","uniprot_name":"PIK1_YEAST","enzyme":true,"transporter":false,"gene_name":"PIK1","num_residues":1066,"molecular_weight":"119922.0","theoretical_pi":"6.46","general_function":"Involved in binding","specific_function":"Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton","reactions":[{"id":1849,"direction":"\u003c\u003e","locations":"vacuole;Golgi;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1850,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2590,"direction":"\u003e","locations":" Peripheral membrane protein.; Cytoplasmic side.; Peripheral membrane protein;Cell membrane; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein. Vacuole membrane;Nucleus","altext":"ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14858,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007046","source":"Smpdb"},{"id":14859,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007047","source":"Smpdb"},{"id":14860,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007048","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"L20220","genbank_protein_id":"432496","gene_card_id":"PIK1","chromosome_location":"chromosome 14","locus":"YNL267W","synonyms":["PI4-kinase","PtdIns-4-kinase"],"enzyme_classes":["2.7.1.67"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" intracellular signal transduction"},{"category":"Process","description":" second-messenger-mediated signaling"},{"category":"Process","description":" phosphoinositide-mediated signaling"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphoinositide metabolic process"},{"category":"Process","description":" phosphoinositide phosphorylation"},{"category":"Process","description":" biological regulation"}],"pfams":[{"name":"PI3_PI4_kinase","identifier":"PF00454"},{"name":"PI3Ka","identifier":"PF00613"},{"name":"Pik1","identifier":"PF11522"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGCATAAAGCATCCAGTTCAAAGAAAAGCTTTGATGATACTATTGAACTAAAAAAAAATGAACAATTACTGAAACTGATCAACTCTAGTGAATTCACCCTTCACAATTGTGTGGAGTTACTGTGCAAACACTCCGAAAATATTGGTATACATTACTATTTATGTCAGAAATTGGCCACATTTCCTCACAGCGAACTACAGTTCTATATTCCCCAACTAGTACAGGTCCTCGTCACCATGGAGACAGAATCAATGGCTTTAGAAGATTTACTATTAAGGTTGAGGGCGGAAAACCCTCATTTTGCACTACTGACGTTTTGGCAGTTACAAGCGTTACTAACGGATTTATCTACTGACCCCGCTTCTTATGGCTTCCAAGTGGCTAGAAGAGTCTTAAACAACTTACAAACCAATCTCTTTAACACAAGTTCAGGTAGCGATAAAAATGTTAAAATACATGAAAACGTTGCACCGGCCTTAGTTCTTTCCTCTATGATAATGTCGGCTATAGCATTCCCCCAATTAAGCGAAGTGACCAAACCATTAGTGGAATCTCAAGGTAGAAGACAAAAAGCTTTCGTTTTTAAGTTGGCTAGAAGTGCAATGAAAGATTTTACCAAGAACATGACCTTGAAAAATACCCTACTAAACAAGAAAACTTCCAGATCCAAAAGAGTTAGCTCAAATCGCAGTTCAACTCCGACTTCTCCAATAGATTTAATAGATCCAATAAAAACTAAAGAAGATGCATCCTTCAGGAAATCCAGACATAGTGAGGTAAAATTGGATTTCGACATTGTGGATGATATAGGTAACCAGGTCTTTGAAGAAAGAATCTCATCTTCAATCAAACTCCCAAAACGTAAACCTAAGTATTTGGATAATTCATACGTTCATAGGACATATGATGGCAAAAATATAAACAGGGACGGAAGCATTTCAAATACCGCAAAGGCTCTCGATGGAAATAAAGGTGATTATATTTCTCCAAAGGGACGTAATGATGAAAATAATGAGATTGGTAACAATGAAGATGAAACTGGTGGTGAAACGGAGGAGGACGCGGACGCTTTAAACTCTGATCACTTCACCAGTTCTATGCCAGATCTGCATAATATTCAACCAAGGACTTCTTCTGCTTCATCTGCTTCTTTAGAAGGGACACCTAAGTTAAACAGGACCAATTCCCAACCCCTTTCGCGCCAGGCATTCAAAAACAGTAAAAAAGCGAATTCTTCTTTGAGTCAAGAAATTGACTTGTCGCAATTATCGACCACTTCAAAAATAAAAATGTTAAAAGCAAATTATTTTCGTTGCGAGACACAATTTGCCATTGCGCTAGAAACAATATCTCAAAGGCTAGCTCGAGTACCGACAGAAGCTAGATTGAGTGCCTTACGAGCCGAGTTGTTTCTATTAAACAGGGACCTACCAGCGGAAGTAGATATCCCCACTTTATTGCCTCCAAATAAAAAAGGAAAGTTACATAAATTAGTGACCATTACTGCTAATGAGGCACAAGTTTTGAACTCTGCAGAAAAAGTTCCATATTTACTCCTGATAGAATACTTGAGAGACGAATTTGATTTTGACCCAACAAGTGAAACCAATGAAAGATTATTAAAGAAGATCAGTGGTAATCAGGGAGGCTTGATATTTGATTTAAATTACATGAATAGAAAAGAAAACAACGAAAATAGAAATGAAAGTACTCTTACTAGCAACAACACTCGATCTTCGGTATATGATAGTAACTCGTTCAACAACGGGGCCTCCCGCAATGAAGGTCTATCCAGTACCTCAAGAAGTGATTCAGCGTCCACAGCTCATGTTAGGACTGAAGTCAATAAAGAGGAAGATTTAGGTGATATGTCAATGGTAAAAGTCAGGAACAGAACGGATGACGAAGCGTATAGAAATGCTTTAGTAATACAGAGTGCCGCAAATGTTCCAATTTTACCTGATGATAGTCAAGACAGAAGCCCAGAGTTGAACTTTGGCTCAAACTTGGACGAAGTACTCATCGAGAATGGAATTAATAGCAAAAATATACATAGCCAAACTGACGCTTTAGCAGACCAGATGAGAGTTTCAGCTGTTATGTTAGCACAATTGGATAAGTCGCCACAACAGTTATCAGAAAGTACCAAACAAATCCGCGCTCAAATTATTTCATCAATGAAGGAGGTGCAGGATAAATTTGGTTACCATGATTTGGAAGCCCTTCATGGAATGGCAGGTGAGAGAAAATTGGAAAACGATTTAATGACGGGTGGTATTGACACTTCATATCTAGGTGAAGATTGGGCTACCAAGAAAGAGAGGATACGTAAAACTTCGGAATATGGCCATTTCGAAAACTGGGATTTATGTTCTGTAATCGCCAAGACGGGTGATGATTTGAGACAGGAGGCGTTTGCATACCAGATGATTCAAGCGATGGCCAATATTTGGGTTAAAGAAAAAGTTGACGTTTGGGTTAAAAGAATGAAAATTTTAATTACTAGTGCGAATACGGGACTTGTGGAGACCATCACAAATGCTATGTCTGTGCATAGTATTAAAAAGGCTTTAACCAAAAAAATGATTGAAGATGCAGAACTAGATGACAAGGGTGGTATTGCCTCTTTGAATGATCACTTCCTTAGAGCTTTTGGTAATCCTAATGGATTTAAGTATAGAAGAGCACAAGACAACTTTGCTTCTTCGTTAGCCGCATATTCTGTCATTTGCTATCTCTTGCAGGTTAAAGATAGACACAACGGTAACATTATGATCGATAACGAAGGCCATGTAAGTCACATCGATTTTGGATTTATGCTATCAAATTCACCCGGCTCAGTGGGCTTTGAGGCCGCACCATTCAAATTAACTTACGAATATATTGAACTGCTAGGCGGAGTAGAGGGAGAAGCGTTTAAAAAGTTTGTTGAACTAACTAAAAGTTCGTTCAAGGCTCTGAGAAAGTATGCTGATCAAATCGTATCAATGTGTGAGATTATGCAAAAGGACAATATGCAGCCTTGTTTCGATGCTGGCGAACAAACAAGTGTACAACTACGACAAAGGTTCCAATTGGACTTATCAGAAAAAGAAGTTGATGACTTCGTAGAAAATTTCTTGATAGGTAAATCTTTGGGTAGTATTTACACCAGAATATACGACCAATTTCAACTTATTACACAGGGTATATATAGCTGA","protein_sequence":"MHKASSSKKSFDDTIELKKNEQLLKLINSSEFTLHNCVELLCKHSENIGIHYYLCQKLATFPHSELQFYIPQLVQVLVTMETESMALEDLLLRLRAENPHFALLTFWQLQALLTDLSTDPASYGFQVARRVLNNLQTNLFNTSSGSDKNVKIHENVAPALVLSSMIMSAIAFPQLSEVTKPLVESQGRRQKAFVFKLARSAMKDFTKNMTLKNTLLNKKTSRSKRVSSNRSSTPTSPIDLIDPIKTKEDASFRKSRHSEVKLDFDIVDDIGNQVFEERISSSIKLPKRKPKYLDNSYVHRTYDGKNINRDGSISNTAKALDGNKGDYISPKGRNDENNEIGNNEDETGGETEEDADALNSDHFTSSMPDLHNIQPRTSSASSASLEGTPKLNRTNSQPLSRQAFKNSKKANSSLSQEIDLSQLSTTSKIKMLKANYFRCETQFAIALETISQRLARVPTEARLSALRAELFLLNRDLPAEVDIPTLLPPNKKGKLHKLVTITANEAQVLNSAEKVPYLLLIEYLRDEFDFDPTSETNERLLKKISGNQGGLIFDLNYMNRKENNENRNESTLTSNNTRSSVYDSNSFNNGASRNEGLSSTSRSDSASTAHVRTEVNKEEDLGDMSMVKVRNRTDDEAYRNALVIQSAANVPILPDDSQDRSPELNFGSNLDEVLIENGINSKNIHSQTDALADQMRVSAVMLAQLDKSPQQLSESTKQIRAQIISSMKEVQDKFGYHDLEALHGMAGERKLENDLMTGGIDTSYLGEDWATKKERIRKTSEYGHFENWDLCSVIAKTGDDLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKILITSANTGLVETITNAMSVHSIKKALTKKMIEDAELDDKGGIASLNDHFLRAFGNPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELLGGVEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLSEKEVDDFVENFLIGKSLGSIYTRIYDQFQLITQGIYS"},{"created_at":"2011-05-27T03:08:19.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"CDP-diacylglycerol--inositol 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Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane","altext":"CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"21-41;46-66;76-96;99-119;146-166;171-191","pdb_id":null,"cellular_location":"Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. 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Involved in cell wall biosynthesis","reactions":[{"id":2769,"direction":"\u003e","locations":"Membrane;Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential); Single-pass membrane protein (Potential)","altext":"UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"13-33;53-73","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"U33007","genbank_protein_id":"927688","gene_card_id":"GPI19","chromosome_location":"chromosome 4","locus":"YDR437W","synonyms":[],"enzyme_classes":["2.4.1.198"],"go_classes":[],"pfams":[{"name":"PIG-P","identifier":"PF08510"}],"pathways":[{"name":"Glycosylphosphatidylinositol(GPI)-anchor 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(Potential)","genbank_gene_id":"U66864","genbank_protein_id":"1620666","gene_card_id":"GPI1","chromosome_location":"chromosome 7","locus":"YGR216C","synonyms":[],"enzyme_classes":["2.4.1.198"],"go_classes":[{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Function","description":" UDP-glycosyltransferase activity"},{"category":"Function","description":" acetylglucosaminyltransferase activity"},{"category":"Function","description":" phosphatidylinositol N-acetylglucosaminyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Process","description":" protein amino acid lipidation"},{"category":"Process","description":" GPI anchor biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"}],"pfams":[{"name":"Gpi1","identifier":"PF05024"}],"pathways":[{"name":"Glycosylphosphatidylinositol(GPI)-anchor 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N-acetylglucosaminyltransferase GPI3 subunit","uniprot_id":"P32363","uniprot_name":"GPI3_YEAST","enzyme":true,"transporter":false,"gene_name":"SPT14","num_residues":452,"molecular_weight":"51241.80078","theoretical_pi":"7.28","general_function":"Involved in biosynthetic process","specific_function":"Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis","reactions":[{"id":2769,"direction":"\u003e","locations":"Membrane;Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential); Single-pass membrane protein (Potential)","altext":"UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"407-427","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)","genbank_gene_id":"X63290","genbank_protein_id":"441475","gene_card_id":"SPT14","chromosome_location":"chromosome 16","locus":"YPL175W","synonyms":["GlcNAc-PI synthesis protein"],"enzyme_classes":["2.4.1.198"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" protein amino acid lipidation"},{"category":"Process","description":" GPI anchor biosynthetic process"}],"pfams":[{"name":"Glycos_transf_1","identifier":"PF00534"},{"name":"PIGA","identifier":"PF08288"}],"pathways":[{"name":"Glycosylphosphatidylinositol(GPI)-anchor biosynthesis","kegg_map_id":"00563"}],"gene_sequence":"ATGGGCTTCAATATAGCGATGCTGTGCGACTTTTTTTATCCACAGTTAGGTGGAGTCGAATTCCATATATATCATTTATCGCAGAAACTAATCGATTTGGGCCATTCTGTCGTCATTATAACTCACGCTTACAAAGATCGAGTCGGCGTACGACATCTTACCAACGGTCTAAAGGTCTATCACGTACCATTTTTTGTGATTTTCAGAGAAACCACTTTCCCCACTGTTTTTTCAACATTTCCAATAATAAGGAATATTCTTCTCAGAGAGCAGATCCAAATTGTTCATTCTCATGGTAGCGCTTCCACGTTCGCTCACGAGGGAATTCTTCATGCTAATACTATGGGATTGAGAACTGTGTTCACGGACCATTCACTCTACGGTTTTAATAACTTAACGTCGATTTGGGTGAATAAGTTGCTAACATTTACCTTGACAAACATAGATCGGGTTATATGTGTTTCTAATACATGCAAAGAAAATATGATTGTTAGAACAGAATTAAGTCCTGATATAATCTCAGTAATTCCCAACGCAGTGGTGAGCGAAGATTTCAAACCAAGGGATCCTACTGGTGGCACCAAGAGAAAACAAAGTAGGGATAAGATAGTGATCGTGGTCATCGGAAGGCTCTTTCCAAACAAAGGGTCCGATTTACTTACTCGCATAATTCCGAAAGTTTGTTCCTCACATGAAGATGTCGAATTTATAGTAGCGGGCGATGGTCCAAAGTTCATAGATTTTCAACAAATGATTGAAAGTCATAGACTACAAAAACGTGTGCAACTCTTAGGCTCTGTTCCACATGAGAAAGTCAGGGATGTATTATGTCAAGGTGACATATATTTACACGCTAGTTTAACAGAAGCATTTGGTACAATTCTAGTTGAGGCCGCATCTTGTAATTTGCTAATTGTAACGACACAAGTCGGAGGAATTCCCGAAGTGTTACCAAATGAGATGACTGTTTATGCAGAACAGACATCCGTTTCTGACCTTGTTCAAGCAACAAATAAAGCTATCAATATCATAAGAAGTAAAGCTTTGGACACTTCCTCTTTTCATGATAGCGTGTCTAAAATGTACGACTGGATGGACGTAGCCAAAAGGACAGTAGAGATATATACTAATATATCTTCTACTTCTTCCGCTGATGATAAAGATTGGATGAAAATGGTAGCAAATCTTTACAAAAGAGATGGAATCTGGGCTAAACATCTTTATCTGTTATGTGGAATTGTAGAGTACATGCTTTTTTTCCTCTTAGAGTGGCTATACCCCAGGGATGAAATCGATCTAGCTCCAAAATGGCCCAAGAAAACAGTGTCTAACGAGACGAAGGAAGCAAGAGAAACTTAA","protein_sequence":"MGFNIAMLCDFFYPQLGGVEFHIYHLSQKLIDLGHSVVIITHAYKDRVGVRHLTNGLKVYHVPFFVIFRETTFPTVFSTFPIIRNILLREQIQIVHSHGSASTFAHEGILHANTMGLRTVFTDHSLYGFNNLTSIWVNKLLTFTLTNIDRVICVSNTCKENMIVRTELSPDIISVIPNAVVSEDFKPRDPTGGTKRKQSRDKIVIVVIGRLFPNKGSDLLTRIIPKVCSSHEDVEFIVAGDGPKFIDFQQMIESHRLQKRVQLLGSVPHEKVRDVLCQGDIYLHASLTEAFGTILVEAASCNLLIVTTQVGGIPEVLPNEMTVYAEQTSVSDLVQATNKAINIIRSKALDTSSFHDSVSKMYDWMDVAKRTVEIYTNISSTSSADDKDWMKMVANLYKRDGIWAKHLYLLCGIVEYMLFFLLEWLYPRDEIDLAPKWPKKTVSNETKEARET"},{"created_at":"2011-05-27T05:21:51.000Z","updated_at":"2011-05-27T15:01:24.000Z","name":"Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit","uniprot_id":"P46961","uniprot_name":"GPI2_YEAST","enzyme":true,"transporter":false,"gene_name":"GPI2","num_residues":280,"molecular_weight":"32576.80078","theoretical_pi":"9.77","general_function":"Involved in phosphatidylinositol N-acetylglucosaminyltransferase activity","specific_function":"Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis","reactions":[{"id":2769,"direction":"\u003e","locations":"Membrane;Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential); Single-pass membrane protein (Potential)","altext":"UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"54-74;76-96;109-129;136-156;190-210;221-241","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"AY692961","genbank_protein_id":"51013373","gene_card_id":"GPI2","chromosome_location":"chromosome 16","locus":"YPL076W","synonyms":[],"enzyme_classes":["2.4.1.198"],"go_classes":[{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Function","description":" UDP-glycosyltransferase activity"},{"category":"Function","description":" acetylglucosaminyltransferase activity"},{"category":"Function","description":" phosphatidylinositol N-acetylglucosaminyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Process","description":" protein amino acid lipidation"},{"category":"Process","description":" GPI anchor biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"}],"pfams":[{"name":"GPI2","identifier":"PF06432"}],"pathways":[{"name":"Glycosylphosphatidylinositol(GPI)-anchor biosynthesis","kegg_map_id":"00563"}],"gene_sequence":"ATGACAAGATCTCCCTGGAAGCGCCTACTATGGTTGAAACAGGAGTACCCAGATAATTATACAGATCCAAGTTTTATTGAGTTGAGAGCAAGACAAAAGGCTGAGAGTAACCAGAAGTCTGATAGAAAATTATCAGAAGCTGCTCGCGCTCAAATTAGGTTGGATTTTATAAGTTTCTACCAAACCATATTGAACACTTCTTTCATTTACATCACTTTTACATATATTTACTATTATGGCTTCGATCCTATTCCGCCAACTATTTTCCTTTCATTTATAACATTGATTATATCAAGGACGAAAGTCGACCCTCTATTGTCCTCATTCATGGACGTAAAGTCTTCGCTGATTATCACATTTGCAATGTTGACTCTCTCTCCAGTCCTCAAATCTCTTTCTAAAACAACTGCATCTGATTCCATATGGACATTGTCTTTTTGGCTGACCCTATGGTACATTTTCGTTATTTCGTCAACAAAGTCCAAAGATAAACCCTCTAACCTTTCCACCAATATACTTGTCGCCCTTGTTGCTGTCCTATCATCGAGGCTTTCGACCACGATCGACGTATTCTGTTTTCTTTTAATTTGTATTCAGTTGAATATCATTCTACCCACTTATTTATCGGTGACGAATAAGGTAGTACCAATAATTTCAAATATTATTGTATACTCATTTTTGAATGTTGCTCTAGGTTGGATTTATATGCTGTTGATTTTCTTTGCTTCAGTATTTTATATTACTGTTTTACCTAAGTGGTTCATCTACTGGAAAATCAATTATCATAAACGGGATAACGATCTACTAAGTACATGGGATGCAAGAACACCAATATTGGATTAG","protein_sequence":"MTRSPWKRLLWLKQEYPDNYTDPSFIELRARQKAESNQKSDRKLSEAARAQIRLDFISFYQTILNTSFIYITFTYIYYYGFDPIPPTIFLSFITLIISRTKVDPLLSSFMDVKSSLIITFAMLTLSPVLKSLSKTTASDSIWTLSFWLTLWYIFVISSTKSKDKPSNLSTNILVALVAVLSSRLSTTIDVFCFLLICIQLNIILPTYLSVTNKVVPIISNIIVYSFLNVALGWIYMLLIFFASVFYITVLPKWFIYWKINYHKRDNDLLSTWDARTPILD"},{"created_at":"2011-05-29T04:44:23.000Z","updated_at":"2011-05-29T05:06:53.000Z","name":"Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15","uniprot_id":"P53961","uniprot_name":"GPI15_YEAST","enzyme":true,"transporter":false,"gene_name":"GPI15","num_residues":229,"molecular_weight":"26816.5","theoretical_pi":"10.71","general_function":"Involved in phosphatidylinositol N-acetylglucosaminyltransferase activity","specific_function":"Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis","reactions":[{"id":2769,"direction":"\u003e","locations":"Membrane;Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential); Single-pass membrane protein (Potential)","altext":"UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"59-79;101-121","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"GPI15","chromosome_location":"chromosome 14","locus":"YNL038W","synonyms":["PIGH homolog"],"enzyme_classes":["2.4.1.198"],"go_classes":[],"pfams":[{"name":"PIG-H","identifier":"PF10181"}],"pathways":[{"name":"Glycosylphosphatidylinositol(GPI)-anchor biosynthesis","kegg_map_id":"00563"}],"gene_sequence":"ATGATTAGTAAAGAGTATGAATTTGGTAAGACTAGTATACTGAATAGAAAGAAGTATACATTAGTTATCGATGAAGACAAGAATGGCAATTTTATAAGATTTACCGTTTTACCTGTATCTAACCGAAAGTTCAAAAAAGTCAAGCAAAATGGGAGGGTAGAGATTAACATGGGCATACAATATCACCAAATTGTACTTATTTTACTACTGAATATTTTGTTCTATGTAATTTGCCTAAGATCAAGATTTCTCGAACATATTAATAGAACTTTTGAAGTGACAATCGCGCGAAGTTTCCAGATCTTAATTATAATGGGATTGTTTGCCTTAGGTACAATTATACTTGTGAGGGGACCTAGTGTGGAAACTGTAACAATTTTCAAAGAAAGTGGACTACAGCTGTCCAGAGTGAAGGGTATGGTTATATTTCCTCAACAATGGAATCGGAAGTTCTTTGAACAAGTAGAGTTTATATCCAATGAAAGAATTATTGATGTAGTGATCAATGAAGGATTCTGTCGGGGATTTCGAGTGATATTCTATCTTGCAGCAATTGTACGTAAATCGTCTACGCTTAAGCTATTATTTCCAGTATGTATTCAAGCGAATTTAAGATTGTTTCTTACTTCAACGATCTGATTAGAAATACTAACACAACAATGCAGTCAAATTTGCCCAGTATCGATGACCAACGTCTAATATACAACATATCTAGAAAATATCTCAGTAAGCAAGAAAAACCCCTGAGCAGACCAAAAGATTGA","protein_sequence":"MISKEYEFGKTSILNRKKYTLVIDEDKNGNFIRFTVLPVSNRKFKKVKQNGRVEINMGIQYHQIVLILLLNILFYVICLRSRFLEHINRTFEVTIARSFQILIIMGLFALGTIILVRGPSVETVTIFKESGLQLSRVKGMVIFPQQWNRKFFEQVEFISNERIIDVVINEGFCRGFRVIFYLAAIVRKSSTLKLLFPSNLPSIDDQRLIYNISRKYLSKQEKPLSRPKD"},{"created_at":"2016-09-09T22:41:19.000Z","updated_at":"2016-09-09T22:41:21.000Z","name":"Serine/threonine-protein kinase VPS15","uniprot_id":"P22219","uniprot_name":"VPS15","enzyme":true,"transporter":true,"gene_name":"VPS15","num_residues":1454,"molecular_weight":"166370.295","theoretical_pi":null,"general_function":"vacuole inheritance","specific_function":"Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole.","reactions":[{"id":14858,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007046","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":"3GRE","cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Golgi-retention defective mutant protein 8","Vacuolar protein sorting-associated protein 15"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"inositol lipid-mediated signaling"},{"category":"Function","description":"late endosome to vacuole transport"},{"category":"Function","description":"macroautophagy"},{"category":"Function","description":"pexophagy"},{"category":"Function","description":"positive regulation of transcription elongation from RNA polymerase II promoter"},{"category":"Function","description":"protein retention in Golgi apparatus"},{"category":"Function","description":"ATP binding"},{"category":"Function","description":"protein targeting to vacuole"},{"category":"Function","description":"protein serine/threonine kinase activity"},{"category":"Function","description":"vacuole inheritance"},{"category":"Function","description":"endosome membrane"},{"category":"Function","description":"Golgi apparatus"},{"category":"Function","description":"protein phosphorylation"},{"category":"Function","description":"late endosome"},{"category":"Function","description":"nucleus-vacuole junction"},{"category":"Function","description":"phosphatidylinositol 3-kinase complex, class III, type I"},{"category":"Function","description":"phosphatidylinositol 3-kinase complex, class III, type II"},{"category":"Function","description":"ubiquitin binding"}],"pfams":[],"pathways":[{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGGGGCACAATTATCACTAGTGGTCCAAGCATCACCTTCCATAGCCATTTTTTCATATATCGATGTCTTAGAGGAAGTACACTACGTTTCACAGTTAAACTCATCAAGATTCTTAAAAACATGCAAGGCACTGGACCCTAACGGCGAAATTGTTATCAAAGTGTTTATTAAACCAAAAGACCAATATAGCTTACGACCTTTTCTCCAACGTATAAGGGCTCAATCGTTTAAGTTGGGACAACTACCGCACGTTTTAAACTACAGTAAATTGATCGAGACAAATAGAGCCGGCTACATGATACGGCAGCACTTAAAAAATAATTTATATGACAGATTGAGTTTGAGACCTTACTTACAAGACATTGAACTGAAATTCATTGCTTTCCAGTTGTTAAATGCATTAAAGGACATTCATAATCTGAATATTGTCCATGGTGATATAAAGACAGAAAATATCCTAGTAACAAGTTGGAATTGGTGTATATTGACAGATTTTGCTGCATTTATCAAACCCGTATATTTGCCTGAAGATAATCCAGGTGAATTTTTATTCTACTTCGACACCTCGAAGAGAAGAACCTGTTATCTAGCCCCGGAGAGGTTTAACTCTAAACTTTACCAAGATGGAAAATCTAACAATGGTAGGCTAACTAAAGAAATGGACATATTTAGTCTTGGATGTGTTATTGCAGAAATATTTGCTGAAGGAAGACCCATCTTCAACTTATCACAGCTATTCAAATATAAAAGTAATTCATATGACGTAAACAGGGAATTTCTCATGGAGGAAATGAATTCTACCGATTTAAGGAACTTGGTTCTAGACATGATTCAACTAGATCCATCCAAAAGACTTTCATGTGATGAACTACTGAATAAATATCGTGGCATTTTCTTCCCCGATTATTTCTACACTTTCATTTATGATTATTTCAGAAATTTGGTTACTATGACAACAAGCACACCGATATCAGATAACACTTGCACCAATAGTACCTTGGAAGACAATGTAAAACTTTTAGATGAAACTACGGAAAAAATATACAGAGATTTTTCCCAAATATGTCATTGTTTGGACTTTCCTTTAATAAAAGACGGGGGTGAGATTGGTTCAGACCCCCCAATTTTGGAATCTTACAAAATAGAGATAGAAATTAGTCGGTTTTTAAACACAAACTTATATTTCCCCCAAAATTACCATTTAGTCTTACAGCAGTTTACCAAAGTATCCGAAAAGATAAAATCAGTTAAAGAGGAATGTGCCTTACTCTTTATCTCTTATTTGTCTCATAGTATAAGAAGTATTGTTTCGACTGCTACGAAACTTAAAAATTTAGAACTATTAGCAGTATTTGCACAATTCGTTTCTGATGAAAATAAAATTGATCGAGTCGTACCTTATTTCGTATGTTGTTTTGAAGATAGTGACCAGGACGTCCAGGCCCTATCTTTGTTAACATTAATCCAGGTACTCACCTCTGTAAGAAAATTGAATCAATTGAACGAGAATATATTTGTGGACTACTTACTTCCGAGACTGAAAAGATTACTTATTTCCAATAGGCAGAATACCAATTATTTAAGGATTGTGTTTGCTAATTGTTTGAGCGACTTGGCCATTATCATTAATAGATTTCAAGAATTTACATTTGCTCAGCACTGCAATGATAACTCAATGGATAACAACACGGAAATCATGGAAAGCAGTACCAAGTATTCAGCAAAATTGATCCAAAGTGTCGAAGATTTAACTGTCTCTTTTTTAACAGATAATGATACTTATGTAAAGATGGCACTTTTGCAAAACATTCTTCCACTTTGTAAATTTTTTGGTAGGGAAAGAACAAACGATATTATACTGAGTCATTTAATAACCTACCTTAATGATAAGGACCCAGCATTGCGAGTTTCCTTAATTCAAACAATATCCGGAATATCAATTCTTTTGGGTACCGTTACATTAGAACAGTATATTTTACCATTGTTAATCCAGACCATCACTGATTCGGAAGAATTAGTAGTGATCAGTGTTTTACAAAGCTTAAAATCTTTGTTCAAGACTGGGTTGATTAGGAAAAAATATTATATTGATATATCAAAAACAACATCTCCCTTGTTGTTGCATCCTAATAATTGGATAAGACAGTTTACTTTGATGATAATTATAGAAATTATTAATAAGTTATCAAAAGCCGAAGTGTACTGCATTCTCTATCCAATAATAAGGCCTTTCTTCGAATTTGACGTTGAGTTCAACTTCAAATCAATGATAAGCTGTTGCAAGCAACCAGTGTCAAGATCGGTTTACAATCTATTGTGTAGTTGGTCTGTTAGAGCGTCAAAATCTTTATTTTGGAAAAAAATCATCACAAATCATGTAGATTCATTCGGAAATAATAGAATCGAATTTATAACAAAAAATTACTCAAGTAAAAATTATGGATTTAATAAAAGAGATACGAAATCAAGTTCCTCGCTGAAGGGTATTAAAACATCATCCACCGTCTATTCACATGACAACAAGGAAATTCCCTTAACTGCTGAAGACAGAAATTGGATTGATAAGTTCCACATTATTGGGCTAACAGAAAAAGATATTTGGAAAATTGTGGCTTTGAGGGGTTATGTAATAAGGACAGCGAGAGTTATGGCAGCGAACCCTGATTTTCCATATAATAATAGTAATTACCGTCCATTAGTACAGAACTCACCACCTAACCTAAACCTTACGAATATTATGCCAAGAAACATTTTCTTTGATGTAGAGTTTGCTGAAGAGTCGACAAGTGAGGGACAAGATTCTAACTTAGAGAACCAACAGATATATAAATATGATGAAAGTGAGAAAGATAGCAATAAGCTAAATATTAACGGTAGCAAACAGCTATCTACCGTCATGGACATAAATGGATCACTAATATTCAAAAATAAGTCCATTGCCACTACTACTTCTAATTTGAAGAACGTTTTTGTTCAGTTAGAACCAACGTCCTATCACATGCATTCTCCAAATCATGGCTTGAAAGATAATGCAAATGTTAAACCAGAAAGGAAGGTAGTCGTCAGCAACAGCTATGAAGGCGACGTTGAAAGCATAGAAAAATTCCTATCGACTTTCAAAATTTTACCTCCTCTGAGAGATTATAAGGAGTTTGGGCCTATTCAAGAGATTGTACGGAGTCCAAACATGGGTAATTTGAGGGGCAAGTTGATAGCTACTTTGATGGAAAACGAACCCAATTCTATTACGTCTTCTGCTGTTTCTCCAGGAGAAACACCCTATTTAATAACAGGTTCAGATCAAGGTGTAATCAAGATTTGGAACCTGAAAGAGATTATCGTGGGCGAGGTTTACTCTTCTTCTTTAACTTATGACTGCTCCTCTACCGTAACTCAGATAACCATGATTCCTAACTTTGACGCGTTTGCCGTTTCCAGTAAAGATGGACAAATAATTGTATTAAAGGTTAATCATTACCAACAAGAAAGTGAAGTCAAATTTTTGAATTGCGAATGCATCAGGAAAATTAACTTGAAGAATTTTGGTAAAAATGAATACGCAGTGAGAATGAGAGCATTTGTGAATGAGGAAAAATCTCTACTAGTAGCATTGACGAATTTGTCAAGGGTTATTATATTTGATATTAGAACCCTGGAGAGGTTACAAATTATAGAGAATTCTCCAAGGCATGGTGCCGTTTCAAGCATCTGTATCGATGAAGAGTGTTGTGTCCTAATTTTGGGGACGACTAGAGGTATTATTGATATATGGGATATCCGTTTCAACGTGCTGATAAGGAGTTGGTCCTTTGGGGACCACGCACCAATCACGCATGTGGAGGTTTGTCAGTTTTATGGAAAGAATTCTGTAATTGTTGTAGGAGGTAGTTCAAAAACATTTCTAACAATATGGAATTTTGTTAAGGGGCATTGTCAGTATGCTTTCATAAATTCTGATGAACAGCCATCTATGGAGCACTTTTTACCAATTGAGAAAGGCTTAGAAGAATTAAATTTTTGTGGAATCAGGTCTTTAAACGCACTAAGCACTATCTCAGTATCTAATGATAAAATTCTTCTTACCGATGAAGCAACAAGTTCCATTGTTATGTTTAGCCTAAATGAGCTTTCTTCTTCTAAAGCAGTAATAAGTCCTTCAAGATTCAGTGACGTTTTTATTCCTACACAAGTTACGGCAAATCTCACAATGTTATTGAGAAAAATGAAACGTACTAGCACTCATTCAGTAGATGATTCTCTATATCATCATGATATTATAAATTCTATATCTACATGTGAAGTTGATGAGACACCTTTGCTGGTTGCTTGTGATAACTCAGGGCTTATTGGAATCTTCCAATAA","protein_sequence":"MGAQLSLVVQASPSIAIFSYIDVLEEVHYVSQLNSSRFLKTCKALDPNGEIVIKVFIKPKDQYSLRPFLQRIRAQSFKLGQLPHVLNYSKLIETNRAGYMIRQHLKNNLYDRLSLRPYLQDIELKFIAFQLLNALKDIHNLNIVHGDIKTENILVTSWNWCILTDFAAFIKPVYLPEDNPGEFLFYFDTSKRRTCYLAPERFNSKLYQDGKSNNGRLTKEMDIFSLGCVIAEIFAEGRPIFNLSQLFKYKSNSYDVNREFLMEEMNSTDLRNLVLDMIQLDPSKRLSCDELLNKYRGIFFPDYFYTFIYDYFRNLVTMTTSTPISDNTCTNSTLEDNVKLLDETTEKIYRDFSQICHCLDFPLIKDGGEIGSDPPILESYKIEIEISRFLNTNLYFPQNYHLVLQQFTKVSEKIKSVKEECALLFISYLSHSIRSIVSTATKLKNLELLAVFAQFVSDENKIDRVVPYFVCCFEDSDQDVQALSLLTLIQVLTSVRKLNQLNENIFVDYLLPRLKRLLISNRQNTNYLRIVFANCLSDLAIIINRFQEFTFAQHCNDNSMDNNTEIMESSTKYSAKLIQSVEDLTVSFLTDNDTYVKMALLQNILPLCKFFGRERTNDIILSHLITYLNDKDPALRVSLIQTISGISILLGTVTLEQYILPLLIQTITDSEELVVISVLQSLKSLFKTGLIRKKYYIDISKTTSPLLLHPNNWIRQFTLMIIIEIINKLSKAEVYCILYPIIRPFFEFDVEFNFKSMISCCKQPVSRSVYNLLCSWSVRASKSLFWKKIITNHVDSFGNNRIEFITKNYSSKNYGFNKRDTKSSSSLKGIKTSSTVYSHDNKEIPLTAEDRNWIDKFHIIGLTEKDIWKIVALRGYVIRTARVMAANPDFPYNNSNYRPLVQNSPPNLNLTNIMPRNIFFDVEFAEESTSEGQDSNLENQQIYKYDESEKDSNKLNINGSKQLSTVMDINGSLIFKNKSIATTTSNLKNVFVQLEPTSYHMHSPNHGLKDNANVKPERKVVVSNSYEGDVESIEKFLSTFKILPPLRDYKEFGPIQEIVRSPNMGNLRGKLIATLMENEPNSITSSAVSPGETPYLITGSDQGVIKIWNLKEIIVGEVYSSSLTYDCSSTVTQITMIPNFDAFAVSSKDGQIIVLKVNHYQQESEVKFLNCECIRKINLKNFGKNEYAVRMRAFVNEEKSLLVALTNLSRVIIFDIRTLERLQIIENSPRHGAVSSICIDEECCVLILGTTRGIIDIWDIRFNVLIRSWSFGDHAPITHVEVCQFYGKNSVIVVGGSSKTFLTIWNFVKGHCQYAFINSDEQPSMEHFLPIEKGLEELNFCGIRSLNALSTISVSNDKILLTDEATSSIVMFSLNELSSSKAVISPSRFSDVFIPTQVTANLTMLLRKMKRTSTHSVDDSLYHHDIINSISTCEVDETPLLVACDNSGLIGIFQ"},{"created_at":"2016-09-09T22:48:58.000Z","updated_at":"2016-09-09T22:48:59.000Z","name":"Vacuolar protein sorting-associated protein 30","uniprot_id":"Q02948","uniprot_name":"VPS30","enzyme":false,"transporter":true,"gene_name":"VPS30","num_residues":557,"molecular_weight":"63260.22","theoretical_pi":null,"general_function":"retrograde transport, endosome to Golgi","specific_function":"Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Plays also a role in regulation of filamentous growth.","reactions":[{"id":14858,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007046","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":"3VP7","cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Autophagy-related protein 6"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"cytoplasmic, membrane-bounded vesicle"},{"category":"Function","description":"pre-autophagosomal structure"},{"category":"Function","description":"pre-autophagosomal structure membrane"},{"category":"Function","description":"autophagosome assembly"},{"category":"Function","description":"autophagy"},{"category":"Function","description":"cellular response to nitrogen starvation"},{"category":"Function","description":"cytosol"},{"category":"Function","description":"CVT pathway"},{"category":"Function","description":"cytoplasm"},{"category":"Function","description":"phosphatidylinositol biosynthetic process"},{"category":"Function","description":"endosome membrane"},{"category":"Function","description":"piecemeal microautophagy of nucleus"},{"category":"Function","description":"phosphatidylinositol 3-kinase complex, class III, type I"},{"category":"Function","description":"retrograde transport, endosome to Golgi"},{"category":"Function","description":"phosphatidylinositol 3-kinase complex, class III, type II"},{"category":"Function","description":"late endosome to vacuole transport"},{"category":"Function","description":"macroautophagy"},{"category":"Function","description":"pexophagy"},{"category":"Function","description":"protein targeting to vacuole"},{"category":"Function","description":"extrinsic component of membrane"}],"pfams":[],"pathways":[{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGAAGTGCCAAACATGTCACTTACCCCTGCAACTAGACCCATCTTTAGAAGGTCTTAGTTTAACCCAAAGAAATTTGCTACTTTCAAATAATTCAATTATCACTGCAACGAATGAAAATGTCATCAGCAACAAGGGCATCGAAGCCGCAGATAATTGTGGGCCTCAAATACCGAAGGAGAGGCTGAGGCGATTAGGGGAGATTCAGAACATAAAAGACTTGAATTTAAAAGATGATAAATTAATCACTGATTCGTTTGTTTTTCTTAATCACGATGATGATGATAATGCTAATATTACGAGTAATAGCAGAGAGGACCAGCGTTATGGAAATGCCAACGGAAATGATAATAAAAAAGCTAATAGTGATACTTCCGATGGAACCAGTACCTTTCGAGATCATGACGAAGAGGAACAAGAAGCTACGGATGAGGACGAAAACCAACAAATACAATTGAATTCCAAGACTTTGTCCACACAAGTCAACGCAATGACTAATGTATTTAACATTCTATCTTCTCAAACAAACATAGACTTTCCTATCTGTCAGGACTGCTGTAACATCTTGATAAACAGACTAAAAAGTGAGTATGATGATGCAATAAAAGAGAGAGATACTTACGCTCAATTTTTATCGAAGTTAGAGAGTCAAAACAAAGAAATATCAGAAAGCAATAAAGAAAAGCAGTATTCCCATAATCTTTCGGAAAAAGAAAATTTGAAAAAGGAAGAGGAAAGACTCTTGGATCAATTATTACGTTTGGAAATGACAGATGATGACTTAGATGGAGAACTAGTTCGTTTACAAGAAAAGAAAGTTCAACTGGAAAATGAGAAACTCCAAAAACTGAGTGATCAGAATTTAATGGATTTAAATAACATTCAATTCAACAAAAATTTACAGTCATTAAAACTGCAATACGAATTATCCTTGAATCAATTAGATAAGTTGAGGAAAATCAATATTTTCAATGCTACATTCAAAATCTCACATAGCGGCCCCTTTGCCACTATAAATGGATTGAGATTAGGCAGTATACCAGAATCAGTGGTACCTTGGAAGGAAATCAATGCAGCACTGGGCCAATTGATTCTTTTACTGGCTACCATAAACAAAAACCTGAAGATAAATTTAGTAGACTACGAATTACAACCGATGGGTTCATTTTCCAAAATCAAGAAAAGAATGGTTAACAGTGTCGAATATAATAATTCCACTACGAACGCTCCCGGTGATTGGTTGATTCTGCCTGTCTACTATGATGAGAATTTCAATTTGGGGAGAATCTTCCGCAAGGAAACGAAGTTTGATAAATCATTAGAAACAACATTAGAAATAATAAGCGAAATCACTCGGCAGCTTTCTACGATAGCGTCATCATATTCATCTCAAACACTCACAACAAGCCAAGATGAATCTTCAATGAATAACGCAAATGACGTTGAAAATAGTACTTCCATTCTCGAGCTACCCTATATCATGAATAAGGACAAGATTAATGGATTATCCGTCAAATTGCATGGTAGCAGTCCCAACCTTGAATGGACAACGGCTATGAAATTTTTATTAACCAATGTAAAGTGGTTGTTAGCGTTTTCTTCCAATTTACTATCCAAGTCAATTACCTTAAGCCCTACAGTGAATTACAATGATAAGACCATCAGCGGAAACTAA","protein_sequence":"MKCQTCHLPLQLDPSLEGLSLTQRNLLLSNNSIITATNENVISNKGIEAADNCGPQIPKERLRRLGEIQNIKDLNLKDDKLITDSFVFLNHDDDDNANITSNSREDQRYGNANGNDNKKANSDTSDGTSTFRDHDEEEQEATDEDENQQIQLNSKTLSTQVNAMTNVFNILSSQTNIDFPICQDCCNILINRLKSEYDDAIKERDTYAQFLSKLESQNKEISESNKEKQYSHNLSEKENLKKEEERLLDQLLRLEMTDDDLDGELVRLQEKKVQLENEKLQKLSDQNLMDLNNIQFNKNLQSLKLQYELSLNQLDKLRKINIFNATFKISHSGPFATINGLRLGSIPESVVPWKEINAALGQLILLLATINKNLKINLVDYELQPMGSFSKIKKRMVNSVEYNNSTTNAPGDWLILPVYYDENFNLGRIFRKETKFDKSLETTLEIISEITRQLSTIASSYSSQTLTTSQDESSMNNANDVENSTSILELPYIMNKDKINGLSVKLHGSSPNLEWTTAMKFLLTNVKWLLAFSSNLLSKSITLSPTVNYNDKTISGN"}]}