{"ymdb_id":"YMDB00229","created_at":"2011-05-29T16:09:13.000Z","updated_at":"2016-09-08T18:35:12.000Z","name":"Farnesyl pyrophosphate","cas":"13058-04-3","state":"Solid","melting_point":"","description":"Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway used by organisms in the biosynthesis of terpenes and terpenoids.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"endoplasmic reticulum;lipid particle","synthesis_reference":"Castillo-Bocanegra, Rafael.  Synthesis and biological activity of farnesyl pyrophosphate analogs.    (1977),     193 pp. ","chebi_id":"50277","hmdb_id":"HMDB00961","kegg_id":"C00448","pubchem_id":"445713","cs_id":"23092868","foodb_id":null,"wikipedia_link":"Farnesyl pyrophosphate","biocyc_id":"FARNESYL-PP","iupac":"{[hydroxy({[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy})phosphoryl]oxy}phosphonic acid","traditional_iupac":"farnesyl diphosphate","logp":"3.6167330606666663","pka":"3.2043406094078315","alogps_solubility":"8.07e-02 g/l","alogps_logp":"2.40","alogps_logs":"-3.68","acceptor_count":"5","donor_count":"3","rotatable_bond_count":"11","polar_surface_area":"113.28999999999999","refractivity":"96.73049999999999","polarizability":"37.94192720134606","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":null,"pka_strongest_acidic":"1.7672186885241006","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2E,6E)-Farnesyl diphosphate","(2E,6E)-Farnesyl pyrophosphate","(all-E)-Farnesyl diphosphate","(E,E)-Farnesyl diphosphate","(E,E)-Farnesyl pyrophosphate","2-trans,6-trans-Farnesyl diphosphate","2-trans,6-trans-Farnesyl pyrophosphate","all-trans-Farnesyl pyrophosphate","Farnesyl diphosphate","Farnesyl pyrophosphate","Farnesyl pyrophosphic acid","Farnesyl-PP","trans-Farnesyl pyrophosphate","trans-trans-Farnesyl diphosphate","trans-trans-Farnesyl pyrophosphate"],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"},{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null},{"name":"Porphyrin Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":1763050,"citation":"He, B., Chen, P., Chen, S. Y., Vancura, K. L., Michaelis, S., Powers, S. (1991). \"RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins.\" Proc Natl Acad Sci U S A 88:11373-11377."},{"pubmed_id":9858571,"citation":"Sato, M., Sato, K., Nishikawa, S., Hirata, A., Kato, J., Nakano, A. (1999). \"The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis.\" Mol Cell Biol 19:471-483."},{"pubmed_id":12702274,"citation":"Grabinska, K., Palamarczyk, G. (2002). \"Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase.\" FEMS Yeast Res 2:259-265."}],"proteins":[{"created_at":"2011-05-26T18:23:18.000Z","updated_at":"2011-07-22T17:54:38.000Z","name":"Farnesyl pyrophosphate synthase","uniprot_id":"P08524","uniprot_name":"FPPS_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG20","num_residues":352,"molecular_weight":"40483.0","theoretical_pi":"5.11","general_function":"Involved in isoprenoid biosynthetic process","specific_function":"Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate","reactions":[{"id":1466,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1562,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2529,"direction":"\u003e","locations":"Cytoplasm","altext":"Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2530,"direction":"\u003e","locations":"Cytoplasm","altext":"Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14374,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006891","source":"Smpdb"},{"id":14375,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006892","source":"Smpdb"},{"id":14376,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007264","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"J05091","genbank_protein_id":"171517","gene_card_id":"ERG20","chromosome_location":"chromosome 10","locus":"YJL167W","synonyms":["FPP synthase","FPS","Farnesyl diphosphate synthase","Dimethylallyltranstransferase","Geranyltranstransferase"],"enzyme_classes":["2.5.1.10","2.5.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" isoprenoid metabolic process"},{"category":"Process","description":" isoprenoid biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"polyprenyl_synt","identifier":"PF00348"}],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGGCTTCAGAAAAAGAAATTAGGAGAGAGAGATTCTTGAACGTTTTCCCTAAATTAGTAGAGGAATTGAACGCATCGCTTTTGGCTTACGGTATGCCTAAGGAAGCATGTGACTGGTATGCCCACTCATTGAACTACAACACTCCAGGCGGTAAGCTAAATAGAGGTTTGTCCGTTGTGGACACGTATGCTATTCTCTCCAACAAGACCGTTGAACAATTGGGGCAAGAAGAATACGAAAAGGTTGCCATTCTAGGTTGGTGCATTGAGTTGTTGCAGGCTTACTTCTTGGTCGCCGATGATATGATGGACAAGTCCATTACCAGAAGAGGCCAACCATGTTGGTACAAGGTTCCTGAAGTTGGGGAAATTGCCATCAATGACGCATTCATGTTAGAGGCTGCTATCTACAAGCTTTTGAAATCTCACTTCAGAAACGAAAAATACTACATAGATATCACCGAATTGTTCCATGAGGTCACCTTCCAAACCGAATTGGGCCAATTGATGGACTTAATCACTGCACCTGAAGACAAAGTCGACTTGAGTAAGTTCTCCCTAAAGAAGCACTCCTTCATAGTTACTTTCAAGACTGCTTACTATTCTTTCTACTTGCCTGTCGCATTGGCCATGTACGTTGCCGGTATCACGGATGAAAAGGATTTGAAACAAGCCAGAGATGTCTTGATTCCATTGGGTGAATACTTCCAAATTCAAGATGACTACTTAGACTGCTTCGGTACCCCAGAACAGATCGGTAAGATCGGTACAGATATCCAAGATAACAAATGTTCTTGGGTAATCAACAAGGCATTGGAACTTGCTTCCGCAGAACAAAGAAAGACTTTAGACGAAAATTACGGTAAGAAGGACTCAGTCGCAGAAGCCAAATGCAAAAAGATTTTCAATGACTTGAAAATTGAACAGCTATACCACGAATATGAAGAGTCTATTGCCAAGGATTTGAAGGCCAAAATTTCTCAGGTCGATGAGTCTCGTGGCTTCAAAGCTGATGTCTTAACTGCGTTCTTGAACAAAGTTTACAAGAGAAGCAAATAG","protein_sequence":"MASEKEIRRERFLNVFPKLVEELNASLLAYGMPKEACDWYAHSLNYNTPGGKLNRGLSVVDTYAILSNKTVEQLGQEEYEKVAILGWCIELLQAYFLVADDMMDKSITRRGQPCWYKVPEVGEIAINDAFMLEAAIYKLLKSHFRNEKYYIDITELFHEVTFQTELGQLMDLITAPEDKVDLSKFSLKKHSFIVTFKTAYYSFYLPVALAMYVAGITDEKDLKQARDVLIPLGEYFQIQDDYLDCFGTPEQIGKIGTDIQDNKCSWVINKALELASAEQRKTLDENYGKKDSVAEAKCKKIFNDLKIEQLYHEYEESIAKDLKAKISQVDESRGFKADVLTAFLNKVYKRSK"},{"created_at":"2011-05-26T23:22:21.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Repressible alkaline phosphatase","uniprot_id":"P11491","uniprot_name":"PPB_YEAST","enzyme":true,"transporter":false,"gene_name":"PHO8","num_residues":566,"molecular_weight":"63003.60156","theoretical_pi":"5.33","general_function":"Involved in catalytic activity","specific_function":"A phosphate monoester + H(2)O = an alcohol + phosphate","reactions":[{"id":1309,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2499,"direction":"\u003e","locations":"Cytoplasmic;Cytoplasm; Single-pass membrane protein (Potential).;Secreted;Vacuole membrane","altext":"A phosphate monoester + H(2)O = an alcohol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2613,"direction":"\u003e","locations":"Vacuole membrane; Single-pass membrane protein (Potential).","altext":"(2E,6E)-farnesyl diphosphate + H(2)O = (2E,6E)-farnesol + diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2614,"direction":"\u003e","locations":"Vacuole membrane; Single-pass membrane protein (Potential).","altext":"beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructofuranose 2-phosphate + phosphate","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"34-59","pdb_id":null,"cellular_location":"Vacuole membrane; Single-pass membrane protein (Potential).","genbank_gene_id":"M21134","genbank_protein_id":"172164","gene_card_id":"PHO8","chromosome_location":"chromosome 4","locus":"YDR481C","synonyms":[],"enzyme_classes":["3.1.3.1","3.1.7.6","3.1.3.54"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Alk_phosphatase","identifier":"PF00245"}],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"}],"gene_sequence":"ATGATGACTCACAGATTACCAAGCGAACAGACACGTCTTGTTCCTGGATCTGACTCGAGCTCTCGTCCTAAAAAGAGACGGATCTCGAAGAGATCGAAGATAATAGTATCCACTGTGGTCTGTATTGGTTTGTTGCTGGTTTTAGTGCAACTGGCATTTCCAACCAGTTTTGCTATACGTTCTGCATCACACAAGAAGAAGAATGTCATATTCTTCGTGACGGATGGAATGGGACCTGCGTCTTTGTCCATGGCAAGATCATTCAACCAGCACGTTAATGATCTACCTATAGACGACATCCTGACACTTGACGAGCATTTTATCGGGTCTTCGAGAACAAGGTCCTCGGACTCACTAGTCACTGACTCAGCTGCGGGCGCCACCGCATTTGCATCTGCATTAAAGAGCTATAATGGGGCCATCGGCGTTGATCCGCATCACAGACCTTGTGGTACAGTGCTCGAGGCGGCTAAGTTAGCAGGTTATCTCACTGGGCTTGTTGTTACGACAAGAATCACAGATGCCACTCCGGCTTCATTCAGTTCACATGTTGATTACAGATGGCAGGAAGATCTTATTGCTACGCACCAGTTAGGCGAATATCCTCTGGGGAGAGTAGTAGACTTACTCATGGGTGGCGGCAGGAGCCATTTCTACCCTCAAGGCGAAAAGGCTTCTCCATATGGTCACCACGGTGCTAGAAAAGATGGAAGAGATTTAATCGATGAGGCTCAATCTAATGGCTGGCAGTACGTGGGTGACCGTAAAAATTTTGATTCTTTGTTGAAAAGCCACGGTGAAAACGTTACTTTTCCTTTCTTGGGTCTCTTTGCAGATAACGACATTCCTTTTGAAATTGACAGAGATGAAAAGGAGTATCCTTCTCTTAAGGAACAAGTCAAGGTGGCTTTGGGTGCCTTGGAAAAAGCTTCCAATGAGGACAAAGATTCTAATGGGTTTTTCTTAATGGTGGAAGGCTCCAGAATTGACCACGCTGGTCACCAAAACGATCCAGCTTCACAGGTAAGGGAGGTGTTGGCTTTCGATGAAGCATTCCAATACGTTTTGGAGTTTGCTGAAAATTCCGATACGGAGACTGTTTTGGTCTCTACGTCGGATCATGAAACGGGTGGTTTAGTCACTTCAAGACAAGTCACTGCTAGCTATCCTCAGTATGTCTGGTATCCACAGGTGCTTGCCAACGCCACCCATTCAGGTGAGTTTTTGAAAAGAAAACTAGTAGATTTTGTTCATGAACATAAGGGCGCAAGCAGCAAAATAGAAAATTTCATCAAACATGAGATCCTGGAAAAGGATTTGGGCATTTACGATTACACGGAAAGTGATTTAGAAACATTAATTCATTTGGATGACAACGCAAATGCTATCCAAGACAAACTGAATGACATGGTATCATTTAGGGCCCAAATTGGCTGGACCACGCATGGTCACAGCGCAGTCGACGTCAACATATATGCATACGCCAATAAGAAAGCTACATGGTCATATGTCTTGAACAATTTACAAGGCAATCACGAAAATACGGAAGTTGGCCAGTTCTTAGAAAACTTTTTAGAATTGAACCTGAACGAAGTCACTGATTTGATTAGGGACACCAAACACACATCAGATTTTGATGCTACAGAAATAGCTAGTGAAGTACAACATTATGACGAATACTACCATGAGTTGACCAACTGA","protein_sequence":"MMTHTLPSEQTRLVPGSDSSSRPKKRRISKRSKIIVSTVVCIGLLLVLVQLAFPSSFALRSASHKKKNVIFFVTDGMGPASLSMARSFNQHVNDLPIDDILTLDEHFIGSSRTRSSDSLVTDSAAGATAFACALKSYNGAIGVDPHHRPCGTVLEAAKLAGYLTGLVVTTRITDATPASFSSHVDYRWQEDLIATHQLGEYPLGRVVDLLMGGGRSHFYPQGEKASPYGHHGARKDGRDLIDEAQSNGWQYVGDRKNFDSLLKSHGENVTLPFLGLFADNDIPFEIDRDEKEYPSLKEQVKVALGALEKASNEDKDSNGFFLMVEGSRIDHAGHQNDPASQVREVLAFDEAFQYVLEFAENSDTETVLVSTSDHETGGLVTSRQVTASYPQYVWYPQVLANATHSGEFLKRKLVDFVHEHKGASSKIENFIKHEILEKDLGIYDYTDSDLETLIHLDDNANAIQDKLNDMVSFRAQIGWTTHGHSAVDVNIYAYANKKATWSYVLNNLQGNHENTEVGQFLENFLELNLNEVTDLIRDTKHTSDFDATEIASEVQHYDEYYHELTN"},{"created_at":"2011-05-27T03:20:29.000Z","updated_at":"2011-05-29T05:06:38.000Z","name":"Probable undecaprenyl pyrophosphate synthase","uniprot_id":"Q12063","uniprot_name":"UPPS_YEAST","enzyme":true,"transporter":false,"gene_name":"NUS1","num_residues":375,"molecular_weight":"42556.69922","theoretical_pi":"6.95","general_function":"Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups","specific_function":"Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP)","reactions":[{"id":2719,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Lipid droplet. Nucleus membrane; Single-pass membrane protein (Potential)","altext":"(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14431,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006945","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"97-119","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Lipid droplet. Nucleus membrane; Single-pass membrane protein (Potential)","genbank_gene_id":"X83276","genbank_protein_id":"1004302","gene_card_id":"NUS1","chromosome_location":"chromosome 4","locus":"YDL193W","synonyms":["UPP synthase","Di-trans,poly-cis-decaprenylcistransferase","Nuclear undecaprenyl pyrophosphate synthase 1","Undecaprenyl diphosphate synthase","UDS"],"enzyme_classes":["2.5.1.31"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"}],"gene_sequence":"ATGCCCACGATGATCAAAAAGGATGATAAAGCAATGGAGCCCCCTAATGAAAAACCGCATAGAAAGATCGAAAGAGATGATGTTCCAGAATCTTCCAATCACATCCCACCTCCAGAATCTGGTGTTTTAAAGGGCGGTAAAGTTAATTCAAAAACCAGAGCTTTAAAGGCCGTTACAAGTATCATTGCAGACGCCGATGAGAACCCTCAGAAGAAAGTGAACAATGAGACGAATGGAGTCCAAAAGCAAAAGACAGAAGATTTGAGTAAAAGAATAGGTAAATTTGAATACCTTTTTTACAAGTTTTTACTTGTGTTGTTATACATCTGCTTCGGGTTGTTTCGGTACGGTCAATACCAATATAATAAAATGAAACTAAGAATATTCAGTATCATCTACAACCATGCATATACACCACAGTTGATTAGACAGGACGTTATTCCTCTGAAAAAAATTCCTAAAAGGTTGGCCGCTATCTTGGAAGTCAAGCCAGTTGGCGACGTTGGCGGCGGTGTGACAGGTTTATTAAATGACGCGAGTGAAATTGTTTGCTGGACTGTTTCAGCTGGTATAAAACATTTGATGTTGTACGATTACGATGGAATATTACAAAGAAATGTTCCAGAGCTGAGAATGGAAATTCATTCCAACCTGGCTAAATATTTTGGGCCAGCTCATGTTCCAAACTACGCTGTTAAAATACCTCATTCTAACAAGATATTCTACAATCTAGACGGAATTGAAACCGAGACTGATGTAGGCAATGAGATAGAAGCTAACCAAGAAAAGGACAAAATTGCTATTGAAATTTCTTTATTGTCTAACAGAGATGGTAGAGAAACGATTGTCGATCTGACCAAAACTATGGCTGAGTTATGTGCGGTTAACGAATTGAGCGTTTCTGACATCACAATGGATTTAGTTGATTCAGAACTGAAACAACTAGTTGGACCCGAACCAGATTTACTGTTATACTTCGGGCCTTCGTTGGATTTACAAGGGTTCCCACCTTGGCATATTAGATTAACCGAATTTTATTGGGAAAAAGATAACAACGAAGTCATATATTCGGTTTTCATCCGCGGCCTAAGACAGTACGCAGGATGTAAAGTGAATGTTGGTAAATGA","protein_sequence":"MPTMIKKDDKAMEPPNEKPHRKIERDDVPESSNHIPPPESGVLKGGKVNSKTRALKAVTSIIADADENPQKKVNNETNGVQKQKTEDLSKRIGKFEYLFYKFLLVLLYICFGLFRYGQYQYNKMKLRIFSIIYNHAYTPQLIRQDVIPLKKIPKRLAAILEVKPVGDVGGGVTGLLNDASEIVCWTVSAGIKHLMLYDYDGILQRNVPELRMEIHSNLAKYFGPAHVPNYAVKIPHSNKIFYNLDGIETETDVGNEIEANQEKDKIAIEISLLSNRDGRETIVDLTKTMAELCAVNELSVSDITMDLVDSELKQLVGPEPDLLLYFGPSLDLQGFPPWHIRLTEFYWEKDNNEVIYSVFIRGLRQYAGCKVNVGK"},{"created_at":"2011-05-27T03:49:12.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Hexaprenyl pyrophosphate synthase, mitochondrial","uniprot_id":"P18900","uniprot_name":"COQ1_YEAST","enzyme":true,"transporter":false,"gene_name":"COQ1","num_residues":473,"molecular_weight":"52558.89844","theoretical_pi":"9.26","general_function":"Involved in isoprenoid biosynthetic process","specific_function":"Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species","reactions":[{"id":2015,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14430,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006944","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"AY558099","genbank_protein_id":"45270088","gene_card_id":"COQ1","chromosome_location":"chromosome 2","locus":"YBR003W","synonyms":["HPS"],"enzyme_classes":["2.5.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" isoprenoid metabolic process"},{"category":"Process","description":" isoprenoid biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"polyprenyl_synt","identifier":"PF00348"}],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"}],"gene_sequence":"ATGTTTCAAAGGTCTGGCGCTGCTCATCACATCAAATTGATTTCATCTCGAAGATGCCGCTTTAAATCCTCCTTTGCAGTTGCTTTAAACGCTGCCAGTAAGTTGGTAACTCCCAAGATTCTTTGGAATAATCCCATATCATTAGTCTCGAAGGAGATGAACACATTGGCCAAAAATATAGTTGCCCTCATCGGGTCTGGCCATCCGGTGCTAAACAAGGTTACTAGTTACTATTTTGAAACAGAAGGCAAAAAAGTACGTCCCTTGTTAGTGTTGTTGTTGTCAAGAGCACTTTCTGAAATTCCCATGACAGAAAGAAATCACTTGAAAATTGACAAGTCGGATGTTCCTGAGGACCCAATTTACTCTAAACCTAGTCAAAATCAACTATTTCAACGTCCTGCAAGTAGCATATCCCCACTACATATTCTTCACGGTATTAAACCACTAAATCCCTTGACAAAAGGTCCTGAGCCTTTGCCAGAAGAAACTTTTGACAAACAAAGAGGGATTTTACCCAAACAGAGAAGATTAGCAGAGATTGTAGAGATGATACACACTGCGTCTTTACTTCATGATGACGTTATTGATCATTCTGATACAAGAAGAGGAAGGCCAAGCGGAAATGCTGCCTTTACCAACAAGATGGCCGTTTTGGCGGGTGATTTTCTCTTAGGGAGAGCAACAGTGTCAATTTCAAGATTACACAACCCCGAAGTCGTAGAACTAATGTCTAATAGTATTGCGAATCTTGTCGAAGGTGAGTTCATGCAACTGAAAAATACTTCCATTGACGCGGATATCGATACCATCGAAAATGGCCATAAGCTACTTCCGGTTCCTTCTAAAAAGCTTGAAGTTAAAGAGCACGACTTTCGTGTTCCAAGCCGCCAACAGGGGCTGCAATTATCTCATGATCAGATTATAGAAACTGCATTTGAATACTACATACACAAGACCTATCTGAAGACTGCTGCTTTGATATCAAAATCTTGCAGATGTGCTGCTATATTATCTGGGGCATCACCTGCCGTTATCGACGAATGCTATGATTTCGGTAGAAATCTAGGTATATGTTTCCAACTCGTAGATGATATGCTTGATTTTACTGTGTCTGGAAAAGATTTAGGGAAGCCATCCGGCGCGGATCTAAAATTAGGTATTGCTACTGCTCCAGTCTTGTTTGCATGGAAAGAAGACCCATCTTTAGGTCCACTAATTTCACGCAATTTTTCAGAGAGGGGTGATGTTGAAAAAACTATTGATTCTGTGAGACTCCATAATGGTATAGCGAAGACGAAAATACTAGCGGAGGAATATAGGGACAAGGCATTACAAAATCTACGGGATTCTCTTCCTGAATCTGATGCTCGTTCTGCCCTAGAGTTTTTAACTAATAGTATACTAACAAGAAGAAAGTAA","protein_sequence":"MFQRSGAAHHIKLISSRRCRFKSSFAVALNAASKLVTPKILWNNPISLVSKEMNTLAKNIVALIGSGHPVLNKVTSYYFETEGKKVRPLLVLLLSRALSEIPMTERNHLKIDKSDVPEDPIYSKPSQNQLFQRPASSISPLHILHGIKPLNPLTKGPEPLPEETFDKQRGILPKQRRLAEIVEMIHTASLLHDDVIDHSDTRRGRPSGNAAFTNKMAVLAGDFLLGRATVSISRLHNPEVVELMSNSIANLVEGEFMQLKNTSIDADIDTIENGHKLLPVPSKKLEVKEHDFRVPSRQQGLQLSHDQIIETAFEYYIHKTYLKTAALISKSCRCAAILSGASPAVIDECYDFGRNLGICFQLVDDMLDFTVSGKDLGKPSGADLKLGIATAPVLFAWKEDPSLGPLISRNFSERGDVEKTIDSVRLHNGIAKTKILAEEYRDKALQNLRDSLPESDARSALEFLTNSILTRRK"},{"created_at":"2011-05-27T03:49:37.000Z","updated_at":"2011-07-22T17:54:30.000Z","name":"Putative dehydrodolichyl diphosphate synthase","uniprot_id":"Q03175","uniprot_name":"SRT1_YEAST","enzyme":true,"transporter":false,"gene_name":"SRT1","num_residues":343,"molecular_weight":"40199.69922","theoretical_pi":"10.03","general_function":"Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups","specific_function":"Could be a cis-prenyl transferase that adds multiple copies of isopentenyl pyrophosphate (ipp) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (DeDol- PP)","reactions":[{"id":1392,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1393,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1394,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1395,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1396,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1397,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1398,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1399,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1400,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1401,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1402,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1403,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1404,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1405,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1406,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1407,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1408,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1409,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1410,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14431,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006945","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AB013498","genbank_protein_id":"4126459","gene_card_id":"SRT1","chromosome_location":"chromosome 13","locus":"YMR101C","synonyms":["DEDOL-PP synthase"],"enzyme_classes":["2.5.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Prenyltransf","identifier":"PF01255"}],"pathways":[{"name":"Terpenoid backbone 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diphosphate synthase","uniprot_id":"P35196","uniprot_name":"RER2_YEAST","enzyme":true,"transporter":false,"gene_name":"RER2","num_residues":286,"molecular_weight":"32693.30078","theoretical_pi":"7.91","general_function":"Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups","specific_function":"Cis-prenyl transferase that adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP)","reactions":[{"id":1392,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1393,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1394,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1395,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1396,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1397,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1398,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1399,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1400,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1401,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1402,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1403,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1404,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1405,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1406,"direction":"\u003c\u003e","locations":"lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14431,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006945","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Peripheral membrane protein","genbank_gene_id":"AB013497","genbank_protein_id":"4126457","gene_card_id":"RER2","chromosome_location":"chromosome 2","locus":"YBR002C","synonyms":["DEDOL-PP synthase"],"enzyme_classes":["2.5.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Prenyltransf","identifier":"PF01255"}],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"}],"gene_sequence":"ATGGAAACGGATAGTGGTATACCTGGTCATTCATTTGTGTTAAAGTGGACAAAAAACATCTTTTCGCGCACATTGCGTGCATCTAACTGTGTACCTAGACATGTTGGGTTCATCATGGATGGGAACAGGAGATTCGCTAGAAAGAAAGAGATGGACGTAAAGGAGGGCCACGAGGCAGGATTTGTTAGTATGAGTAGAATCTTAGAACTGTGTTATGAAGCAGGAGTCGATACGGCTACCGTGTTTGCCTTTTCAATTGAAAATTTCAAGAGGAGCTCACGGGAAGTTGAATCACTGATGACTTTAGCGCGCGAAAGGATACGACAAATCACAGAACGTGGAGAGCTGGCCTGTAAGTATGGGGTACGCATTAAAATTATCGGCGATCTCTCTTTGTTGGATAAGTCTCTATTAGAAGATGTTCGGGTTGCTGTGGAAACTACAAAGAACAACAAAAGGGCCACGTTAAATATCTGCTTTCCATATACAGGCAGGGAAGAAATCTTGCATGCCATGAAAGAAACAATTGTTCAACATAAGAAGGGCGCCGCTATAGACGAAAGCACGTTAGAATCGCATCTCTACACGGCGGGGGTACCCCCTTTAGATTTATTGATTAGGACAAGTGGCGTTTCCAGATTAAGTGACTTTTTGATATGGCAGGCATCGAGTAAGGGCGTACGCATCGAATTGCTGGATTGTTTATGGCCAGAGTTTGGACCTATACGGATGGCATGGATTTTATTAAAATTTTCGTTTCACAAATCCTTTTTAAACAAAGAGTACAGATTAGAGGAAGGTGATTATGACGAGGAAACCAATGGGGACCCCATCGATTTGAAAGAAAAAAAGTTGAATTAA","protein_sequence":"METDSGIPGHSFVLKWTKNIFSRTLRASNCVPRHVGFIMDGNRRFARKKEMDVKEGHEAGFVSMSRILELCYEAGVDTATVFAFSIENFKRSSREVESLMTLARERIRQITERGELACKYGVRIKIIGDLSLLDKSLLEDVRVAVETTKNNKRATLNICFPYTGREEILHAMKETIVQHKKGAAIDESTLESHLYTAGVPPLDLLIRTSGVSRLSDFLIWQASSKGVRIELLDCLWPEFGPIRMAWILLKFSFHKSFLNKEYRLEEGDYDEETNGDPIDLKEKKLN"},{"created_at":"2011-05-27T04:12:21.000Z","updated_at":"2011-05-27T15:01:22.000Z","name":"Geranylgeranyl transferase type-1 subunit beta","uniprot_id":"P18898","uniprot_name":"PGTB1_YEAST","enzyme":true,"transporter":false,"gene_name":"CDC43","num_residues":376,"molecular_weight":"42689.10156","theoretical_pi":"6.31","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal sequence Cys-Ile-Ile-Leu or Cys-Val-Leu-Leu. Acts, among other substrates, on Rho1 and Rho2 and CDC42 proteins. Participates in a RAS-like C-terminal modification of proteins involved in nuclear division and bud growth. It is involved in bud positioning and cell polarity","reactions":[{"id":2760,"direction":"\u003e","locations":"","altext":"Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M74109","genbank_protein_id":"171147","gene_card_id":"CDC43","chromosome_location":"chromosome 7","locus":"YGL155W","synonyms":["Cell division cycle protein 43","Geranylgeranyl transferase type I subunit beta","GGTase-I-beta","RAS proteins geranylgeranyltransferase subunit beta","Type I protein geranyl-geranyltransferase subunit beta","PGGT"],"enzyme_classes":["2.5.1.59"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Prenyltrans","identifier":"PF00432"}],"pathways":[],"gene_sequence":"ATGTGTCAAGCTACCAATGGCCCGAGTAGAGTTGTGACTAAAAAGCATAGGAAATTTTTCGAAAGACATCTACAGTTGCTTCCCTCTTCACATCAGGGACATGACGTGAACAGAATGGCGATAATATTCTACTCAATCTCAGGACTCTCTATATTTGATGTTAACGTTTCTGCGAAGTACGGCGATCATCTTGGCTGGATGCGCAAACATTATATCAAAACAGTGCTGGATGATACAGAAAATACTGTGATATCTGGATTTGTTGGAAGCTTAGTCATGAATATCCCTCACGCAACAACGATTAATCTACCAAATACTCTCTTTGCATTGTTGTCCATGATTATGCTGAGAGATTACGAGTATTTTGAGACTATACTAGACAAAAGAAGCCTGGCGAGATTTGTTTCTAAGTGCCAACGACCTGACCGTGGCTCGTTTGTATCTTGTTTAGACTATAAGACAAATTGTGGATCTTCGGTTGATTCAGACGATTTAAGGTTTTGCTACATCGCAGTTGCCATTCTGTACATATGCGGATGCCGATCCAAAGAAGACTTTGATGAATACATTGATACTGAGAAGTTGCTTGGCTATATAATGTCGCAACAATGCTACAACGGAGCTTTCGGTGCCCACAATGAACCACACTCAGGGTACACATCTTGTGCGCTGTCTACCTTAGCTTTACTCTCTAGTTTGGAAAAGCTATCAGACAAGTTTAAAGAAGACACCATAACCTGGCTATTACATAGGCAAGTATCAAGCCATGGATGTATGAAATTTGAAAGCGAATTGAATGCCAGCTATGATCAATCTGATGATGGCGGTTTCCAGGGAAGGGAGAACAAGTTCGCTGATACGTGTTACGCATTTTGGTGCTTAAATTCACTACACTTACTAACAAAGGATTGGAAAATGCTATGCCAAACTGAACTAGTCACAAATTATTTGCTTGATCGAACGCAAAAAACATTAACTGGAGGCTTTAGTAAAAATGACGAAGAAGATGCTGATTTATATCACAGCTGTCTAGGGAGCGCTGCGTTAGCATTAATTGAGGGGAAATTTAATGGAGAATTATGCATACCTCAAGAAATATTTAATGATTTTAGTAAAAGGTGCTGTTTTTGA","protein_sequence":"MCQATNGPSRVVTKKHRKFFERHLQLLPSSHQGHDVNRMAIIFYSISGLSIFDVNVSAKYGDHLGWMRKHYIKTVLDDTENTVISGFVGSLVMNIPHATTINLPNTLFALLSMIMLRDYEYFETILDKRSLARFVSKCQRPDRGSFVSCLDYKTNCGSSVDSDDLRFCYIAVAILYICGCRSKEDFDEYIDTEKLLGYIMSQQCYNGAFGAHNEPHSGYTSCALSTLALLSSLEKLSDKFKEDTITWLLHRQVSSHGCMKFESELNASYDQSDDGGFQGRENKFADTCYAFWCLNSLHLLTKDWKMLCQTELVTNYLLDRTQKTLTGGFSKNDEEDADLYHSCLGSAALALIEGKFNGELCIPQEIFNDFSKRCCF"},{"created_at":"2011-05-27T04:18:47.000Z","updated_at":"2011-05-27T15:01:22.000Z","name":"Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha","uniprot_id":"P29703","uniprot_name":"FNTA_YEAST","enzyme":true,"transporter":false,"gene_name":"RAM2","num_residues":316,"molecular_weight":"37507.30078","theoretical_pi":"4.75","general_function":"Involved in protein prenyltransferase activity","specific_function":"Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate","reactions":[{"id":2761,"direction":"\u003e","locations":"","altext":"Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2760,"direction":"\u003e","locations":"","altext":"Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M88584","genbank_protein_id":"172359","gene_card_id":"RAM2","chromosome_location":"chromosome 11","locus":"YKL019W","synonyms":["CAAX farnesyltransferase subunit alpha","FTase-alpha","Ras proteins prenyltransferase subunit alpha","Type I protein geranyl-geranyltransferase subunit alpha","GGTase-I-alpha"],"enzyme_classes":["2.5.1.58","2.5.1.59"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" prenyltransferase activity"},{"category":"Function","description":" protein prenyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" protein amino acid lipidation"},{"category":"Process","description":" protein prenylation"},{"category":"Process","description":" protein amino acid prenylation"}],"pfams":[{"name":"PPTA","identifier":"PF01239"}],"pathways":[],"gene_sequence":"ATGGAGGAGTACGATTATTCAGACGTTAAACCTTTGCCCATTGAGACAGACTTGCAGGATGAACTGTGCAGGATTATGTATACCGAGGATTATAAGCGGTTGATGGGACTCGCAAGGGCTCTGATCAGCCTTAACGAACTGTCACCCAGGGCACTACAGCTAACAGCCGAAATTATCGACGTGGCGCCAGCCTTCTACACCATATGGAACTACCGATTCAATATCGTCAGGCACATGATGAGTGAATCCGAAGACACTGTCTTGTACCTGAACAAGGAATTAGACTGGCTAGATGAAGTTACGCTGAATAATCCAAAGAACTATCAGATCTGGTCCTATAGACAGTCTCTTTTGAAGCTACATCCGTCTCCTTCCTTCAAAAGAGAGCTGCCTATCTTAAAACTGATGATTGATGATGATTCCAAGAATTATCACGTTTGGTCGTACAGAAAGTGGTGCTGTTTGTTCTTCAGTGACTTTCAACATGAGCTCGCCTACGCCAGCGACCTCATCGAGACAGACATTTATAACAACAGCGCATGGACTCATAGGATGTTTTACTGGGTGAACGCTAAAGATGTCATTTCAAAAGTGGAATTGGCCGACGAGCTCCAGTTCATTATGGACAAGATTCAATTGGTTCCGCAGAACATCAGTCCGTGGACCTACCTCCGTGGTTTCCAAGAGCTATTCCATGATAGGCTACAGTGGGATAGCAAAGTAGTCGACTTCGCCACAACCTTCATCGGTGACGTATTGTCACTTCCAATTGGCTCACCAGAGGATTTGCCCGAGATCGAGTCCTCATATGCCCTGGAATTCCTGGCATATCACTGGGGGGCAGACCCTTGTACCCGAGACAACGCTGTTAAGGCCTATAGCTTGCTAGCAATCAAATACGATCCTATTAGAAAAAACTTGTGGCACCACAAAATAAATAATCTGAACTGA","protein_sequence":"MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIIDVAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKLHPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSAWTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSKVVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKYDPIRKNLWHHKINNLN"},{"created_at":"2011-05-27T04:20:38.000Z","updated_at":"2011-05-27T15:01:22.000Z","name":"Squalene synthase","uniprot_id":"P29704","uniprot_name":"FDFT_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG9","num_residues":444,"molecular_weight":"51719.39844","theoretical_pi":"5.75","general_function":"Involved in transferase activity","specific_function":"May regulate the flux of isoprene intermediates through the sterol pathway. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. ERG9 is also essential for cell growth in yeast","reactions":[{"id":1980,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2762,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"2 farnesyl diphosphate = diphosphate + presqualene diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2763,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Presqualene diphosphate + NAD(P)H = squalene + diphosphate + NAD(P)(+).","export":false,"pw_reaction_id":null,"source":null},{"id":14378,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006893","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"291-311;421-441","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"M63979","genbank_protein_id":"171481","gene_card_id":"ERG9","chromosome_location":"chromosome 8","locus":"YHR190W","synonyms":["SQS","SS","FPP:FPP farnesyltransferase","Farnesyl-diphosphate farnesyltransferase"],"enzyme_classes":["2.5.1.21"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" prenyltransferase activity"},{"category":"Function","description":" farnesyltranstransferase activity"},{"category":"Function","description":" farnesyl-diphosphate farnesyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" lipid biosynthetic process"}],"pfams":[{"name":"SQS_PSY","identifier":"PF00494"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGGGAAAGCTATTACAATTGGCATTGCATCCGGTCGAGATGAAGGCAGCTTTGAAGCTGAAGTTTTGCAGAACACCGCTATTCTCCATCTATGATCAGTCCACGTCTCCATATCTCTTGCACTGTTTCGAACTGTTGAACTTGACCTCCAGATCGTTTGCTGCTGTGATCAGAGAGCTGCATCCAGAATTGAGAAACTGTGTTACTCTCTTTTATTTGATTTTAAGGGCTTTGGATACCATCGAAGACGATATGTCCATCGAACACGATTTGAAAATTGACTTGTTGCGTCACTTCCACGAGAAATTGTTGTTAACTAAATGGAGTTTCGACGGAAATGCCCCCGATGTGAAGGACAGAGCCGTTTTGACAGATTTCGAATCGATTCTTATTGAATTCCACAAATTGAAACCAGAATATCAAGAAGTCATCAAGGAGATCACCGAGAAAATGGGTAATGGTATGGCCGACTACATCTTGGATGAAAATTACAACTTGAATGGGTTGCAAACCGTCCACGACTACGACGTGTACTGTCACTACGTAGCTGGTTTGGTCGGTGATGGTTTGACCCGTTTGATTGTCATTGCCAAGTTTGCCAACGAATCTTTGTATTCTAATGAGCAATTGTATGAAAGCATGGGTCTTTTCCTACAAAAAACCAACATCATCAGAGACTACAATGAAGATTTGGTCGATGGTAGATCCTTCTGGCCCAAGGAAATCTGGTCACAATACGCTCCTCAGTTGAAGGACTTCATGAAACCTGAAAACGAACAACTGGGGTTGGACTGTATAAACCACCTCGTCTTAAACGCATTGAGTCATGTTATCGATGTGTTGACTTATTTGGCCAGTATCCACGAGCAATCCACTTTCCAATTTTGTGCCATTCCCCAAGTTATGGCCATTGCAACCTTGGCTTTGGTATTCAACAACCGTGAAGTGCTACATGGCAATGTAAAGATTCGTAAGGGTACTACCTGCTATTTAATTTTGAAATCAAGGACTTTGCGTGGCTGTGTCGAGATTTTTGACTATTACTTACGTGATATCAAATCTAAATTGGCTGTGCAAGATCCAAATTTCTTAAAATTGAACATTCAAATCTCCAAGATCGAACAATTCATGGAAGAAATGTACCAGGATAAATTACCTCCTAACGTGAAGCCAAATGAAACTCCAATTTTCTTGAAAGTTAAAGAAAGATCCAGATACGATGATGAATTGGTCCCAACCCAACAAGAAGAAGAGTACAAGTTCAATATGGTTTTATCTATCATCTTGTCCGTTCTTCTTGGGTTTTATTATATATACACTTTACACAGAGCGTGA","protein_sequence":"MGKLLQLALHPVEMKAALKLKFCRTPLFSIYDQSTSPYLLHCFELLNLTSRSFAAVIRELHPELRNCVTLFYLILRALDTIEDDMSIEHDLKIDLLRHFHEKLLLTKWSFDGNAPDVKDRAVLTDFESILIEFHKLKPEYQEVIKEITEKMGNGMADYILDENYNLNGLQTVHDYDVYCHYVAGLVGDGLTRLIVIAKFANESLYSNEQLYESMGLFLQKTNIIRDYNEDLVDGRSFWPKEIWSQYAPQLKDFMKPENEQLGLDCINHLVLNALSHVIDVLTYLAGIHEQSTFQFCAIPQVMAIATLALVFNNREVLHGNVKIRKGTTCYLILKSRTLRGCVEIFDYYLRDIKSKLAVQDPNFLKLNIQISKIEQFMEEMYQDKLPPNVKPNETPIFLKVKERSRYDDELVPTQQEEEYKFNMVLSIILSVLLGFYYIYTLHRA"},{"created_at":"2011-05-27T05:07:16.000Z","updated_at":"2011-05-27T15:01:23.000Z","name":"Protein farnesyltransferase subunit beta","uniprot_id":"P22007","uniprot_name":"FNTB_YEAST","enzyme":true,"transporter":false,"gene_name":"RAM1","num_residues":431,"molecular_weight":"48189.39844","theoretical_pi":"6.35","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins such as a-factor and RAS. The beta subunit is responsible for peptide-binding","reactions":[{"id":2761,"direction":"\u003e","locations":"","altext":"Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M22753","genbank_protein_id":"171420","gene_card_id":"RAM1","chromosome_location":"chromosome 4","locus":"YDL090C","synonyms":["FTase-beta","CAAX farnesyltransferase subunit beta","Ras proteins prenyltransferase subunit beta"],"enzyme_classes":["2.5.1.58"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Prenyltrans","identifier":"PF00432"}],"pathways":[],"gene_sequence":"ATGCGACAGAGAGTAGGAAGGTCCATAGCTAGGGCTAAATTTATAAATACTGCCTTATTAGGAAGAAAGAGACCAGTTATGGAAAGAGTCGTCGATATAGCGCATGTAGATTCAAGTAAAGCAATCCAACCATTGATGAAGGAACTAGAAACCGACACTACAGAAGCACGATACAAAGTACTACAAAGTGTATTAGAGATATACGATGATGAAAAGAATATAGAACCTGCTCTCACGAAAGAGTTTCACAAAATGTACTTGGATGTCGCTTTTGAGATATCGTTACCTCCACAAATGACAGCACTAGATGCTTCACAACCGTGGATGCTATATTGGATTGCTAACTCATTGAAGGTAATGGACAGAGACTGGCTTTCAGATGACACCAAAAGAAAAATTGTAGATAAGCTCTTTACTATTAGTCCTTCAGGAGGACCCTTTGGTGGAGGTCCTGGCCAATTATCTCATTTGGCCAGCACTTATGCTGCAATTAATGCTCTCTCCCTTTGCGATAACATAGATGGATGCTGGGACAGAATTGATCGAAAAGGAATTTACCAATGGCTGATATCGTTGAAAGAGCCTAATGGAGGATTCAAGACCTGTTTAGAAGTCGGAGAAGTGGATACAAGAGGTATATACTGTGCCTTGAGCATAGCAACCTTATTAAATATTCTTACAGAAGAGCTTACAGAAGGTGTGTTAAACTATTTGAAAAATTGTCAAAATTATGAAGGTGGATTCGGCAGTTGTCCTCACGTAGATGAGGCACACGGAGGCTATACTTTCTGTGCTACAGCTAGTCTAGCAATTTTAAGGTCCATGGACCAAATAAATGTTGAAAAGCTTTTAGAATGGTCTAGTGCTCGTCAATTGCAAGAAGAACGAGGATTTTGCGGAAGGAGCAACAAACTTGTTGACGGTTGCTATAGTTTTTGGGTTGGAGGTTCGGCTGCCATTCTTGAAGCTTTTGGATATGGCCAATGCTTCAACAAACATGCTCTTCGGGACTACATATTGTACTGTTGCCAAGAAAAAGAGCAACCTGGTTTGAGAGATAAACCAGGGGCCCACTCAGACTTTTACCATACAAATTATTGCCTATTAGGACTGGCTGTTGCGGAAAGTTCATACAGTTGCACTCCTAATGATTCTCCACATAATATTAAGTGTACTCCAGACCGCCTAATTGGATCATCGAAACTTACTGATGTCAACCCTGTCTATGGTTTACCAATAGAAAATGTAAGAAAAATTATCCACTACTTTAAATCCAATTTATCTTCTCCAAGTTAA","protein_sequence":"MRQRVGRSIARAKFINTALLGRKRPVMERVVDIAHVDSSKAIQPLMKELETDTTEARYKVLQSVLEIYDDEKNIEPALTKEFHKMYLDVAFEISLPPQMTALDASQPWMLYWIANSLKVMDRDWLSDDTKRKIVDKLFTISPSGGPFGGGPGQLSHLASTYAAINALSLCDNIDGCWDRIDRKGIYQWLISLKEPNGGFKTCLEVGEVDTRGIYCALSIATLLNILTEELTEGVLNYLKNCQNYEGGFGSCPHVDEAHGGYTFCATASLAILRSMDQINVEKLLEWSSARQLQEERGFCGRSNKLVDGCYSFWVGGSAAILEAFGYGQCFNKHALRDYILYCCQEKEQPGLRDKPGAHSDFYHTNYCLLGLAVAESSYSCTPNDSPHNIKCTPDRLIGSSKLTDVNPVYGLPIENVRKIIHYFKSNLSSPS"}]}