Guanosine diphosphate mannose (YMDB00202)

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Identification

YMDB ID

YMDB00202

Name

Guanosine diphosphate mannose

Species

Saccharomyces cerevisiae

Strain

Baker's yeast

Description

Guanosine diphosphate mannose, also known as gdpmannose or GDP-alpha-D-mannose, belongs to the class of organic compounds known as purine nucleotide sugars. These are purine nucleotides bound to a saccharide derivative through the terminal phosphate group. Guanosine diphosphate mannose is a strong basic compound (based on its pKa). Guanosine diphosphate mannose exists in all living species, ranging from bacteria to humans. Within yeast, guanosine diphosphate mannose participates in a number of enzymatic reactions. In particular, (N-acetylglucosaminyl)2-diphosphodolichol and guanosine diphosphate mannose can be converted into mannosyl-(N-acetylglucosaminyl)2-diphosphodolichol; which is mediated by the enzyme chitobiosyldiphosphodolichol beta-mannosyltransferase. In addition, mannosyl-(N-acetylglucosaminyl)2-diphosphodolichol and guanosine diphosphate mannose can be converted into (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol; which is catalyzed by the enzyme Alpha-1,3/1,6-mannosyltransferase ALG2. In yeast, guanosine diphosphate mannose is involved in the metabolic pathway called n-glycan biosynthesis pathway.

Structure

MOL SDF PDB SMILES InChI

Synonyms

GDP mannose
GDP-D-mannose
GDP-glucose
GDP-mannose
Guanosine Diphosphate Mannose
Guanosine diphosphomannose
Guanosine pyrophosphate mannose
GDPmannose
Guanosine 5'-(trihydrogen diphosphate), mono-alpha-D-mannopyranosyl ester
GDP-alpha-D-Mannose
Guanosine 5'-(trihydrogen diphosphate), mono-a-D-mannopyranosyl ester
Guanosine 5'-(trihydrogen diphosphate), mono-α-D-mannopyranosyl ester
Guanosine 5'-(trihydrogen diphosphoric acid), mono-a-D-mannopyranosyl ester
Guanosine 5'-(trihydrogen diphosphoric acid), mono-alpha-D-mannopyranosyl ester
Guanosine 5'-(trihydrogen diphosphoric acid), mono-α-D-mannopyranosyl ester
Guanosine pyrophosphoric acid mannose
GDP-a-D-Mannose
GDP-Α-D-mannose
Guanosine diphosphoric acid mannose
Pyrophosphate mannose, guanosine
Diphosphomannose, guanosine
Mannose, guanosine diphosphate
Diphosphate mannose, guanosine
Mannose, guanosine pyrophosphate
Mannose, GDP
Guanosine 5'-(trihydrogen diphosphate) p'-mannosyl ester
Guanosine 5'-(trihydrogen pyrophosphate) mono-D-mannosyl ester
Guanosine 5'-(trihydrogen pyrophosphate) monomannopyranosyl ester
Guanosine 5'-(trihydrogen pyrophosphate) monomannosyl ester
Guanosine 5'-diphosphate D-mannose
Guanosine 5'-pyrophosphate D-mannosyl ester
Guanosine 5'-pyrophosphate alpha-D-mannosyl ester
Guanosine 5'-pyrophosphate α-D-mannosyl ester
Guanosine 5’-(trihydrogen diphosphate) p’-mannosyl ester
Guanosine 5’-(trihydrogen pyrophosphate) mono-D-mannosyl ester
Guanosine 5’-(trihydrogen pyrophosphate) monomannopyranosyl ester
Guanosine 5’-(trihydrogen pyrophosphate) monomannosyl ester
Guanosine 5’-diphosphate D-mannose
Guanosine 5’-pyrophosphate D-mannosyl ester
Guanosine 5’-pyrophosphate α-D-mannosyl ester

CAS number

3123-67-9

Weight

Average: 605.3411
Monoisotopic: 605.077152801

InChI Key

MVMSCBBUIHUTGJ-GDJBGNAASA-N

InChI

InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1

IUPAC Name

[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid

Traditional IUPAC Name

guanosine diphosphomannose

Chemical Formula

C₁₆H₂₅N₅O₁₆P₂

SMILES

[H]OC([H])([H])[C@@]1([H])O[C@]([H])(OP(=O)(O[H])OP(=O)(O[H])OC([H])([H])[C@@]2([H])O[C@@]([H])(N3C([H])=NC4=C3N=C(N([H])[H])N([H])C4=O)[C@]([H])(O[H])[C@]2([H])O[H])[C@@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]

Chemical Taxonomy

Description

belongs to the class of organic compounds known as purine nucleotide sugars. These are purine nucleotides bound to a saccharide derivative through the terminal phosphate group.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleotides

Sub Class

Purine nucleotide sugars

Direct Parent

Purine nucleotide sugars

Alternative Parents

Substituents

Purine nucleotide sugar
Purine ribonucleoside diphosphate
Purine ribonucleoside monophosphate
Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
Monosaccharide phosphate
Organic pyrophosphate
Imidazopyrimidine
Purine
Hydroxypyrimidine
Monoalkyl phosphate
Monosaccharide
N-substituted imidazole
Organic phosphoric acid derivative
Oxane
Phosphoric acid ester
Alkyl phosphate
Pyrimidine
Heteroaromatic compound
Tetrahydrofuran
Imidazole
Azole
Secondary alcohol
Polyol
Oxacycle
Organoheterocyclic compound
Azacycle
Organic oxygen compound
Alcohol
Organic oxide
Primary alcohol
Hydrocarbon derivative
Organonitrogen compound
Organooxygen compound
Organic nitrogen compound
Organopnictogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

GDP-D-mannose (CHEBI:15820 )

Physical Properties

State

Solid

Charge

Melting point

Not Available

Experimental Properties

Property	Value	Reference
Water Solubility	Not Available	PhysProp
LogP	Not Available	PhysProp

Predicted Properties

Property	Value	Source
Water Solubility	7.77 g/L	ALOGPS
logP	-1.8	ALOGPS
logP	-5.3	ChemAxon
logS	-1.9	ALOGPS
pKa (Strongest Acidic)	1.73	ChemAxon
pKa (Strongest Basic)	-3.6	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	16	ChemAxon
Hydrogen Donor Count	10	ChemAxon
Polar Surface Area	327.43 Å²	ChemAxon
Rotatable Bond Count	9	ChemAxon
Refractivity	118.51 m³·mol⁻¹	ChemAxon
Polarizability	48.72 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	0	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Biological Properties

Cellular Locations

Golgi
cytoplasm

Organoleptic Properties

Not Available

SMPDB Pathways

Amino sugar and nucleotide sugar metabolism	PW002413
Mannose Metabolism	PW002391
N-Glycan biosynthesis	PW002501

KEGG Pathways

Amino sugar and nucleotide sugar metabolism	ec00520
Fructose and mannose metabolism	ec00051
N-Glycan biosynthesis	ec00510

SMPDB Reactions

Guanosine diphosphate mannose + Dolichol phosphate → Guanosine diphosphate + dolichyl β-D-mannosyl phosphate

KEGG Reactions

Beta-1,4-D-Mannosylchitobiosyldiphosphodolichol + Guanosine diphosphate mannose → alpha-D-mannosyl-beta-D-mannosyldiacetylchitobiosyldiphosphodolichol + hydron + Guanosine diphosphate

Guanosine diphosphate mannose + N,N'-diacetylchitobiosyldiphosphodolichol ↔ Beta-1,4-D-Mannosylchitobiosyldiphosphodolichol

dolichyl phosphate + Guanosine diphosphate mannose → Guanosine diphosphate + dolichyl D-mannosyl phosphate

GTP + hydron + D-Mannose 1-phosphate → Pyrophosphate + Guanosine diphosphate mannose

inositol-P-ceramide C (C26) + Guanosine diphosphate mannose ↔ mannosylinositol phosphorylceramide

Concentrations

Intracellular Concentrations

Not Available

Extracellular Concentrations

Not Available

Spectra

Spectrum Type	Description	Splash Key	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-05bu-5842490000-d73f755e03b8ad234b29	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positive	splash10-01r6-7882509000-02adbc06a0f79e803d88	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_3) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_4) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_5) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_6) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_7) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_8) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_9) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_10) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_1) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_2) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_3) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_4) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_5) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_6) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_7) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_8) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_9) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_10) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_11) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_12) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_13) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_14) - 70eV, Positive	Not Available	JSpectraViewer
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF 32V, positive	splash10-0a4i-0000209000-fa2b35ba4f2fbdff74a3	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF 32V, negative	splash10-0udi-3401309000-93213e14894fde4ba5c2	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-0udi-0001309000-586a7f020650fe518e5f	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - 40V, Positive	splash10-0udi-0900000000-bba5489b865ff8d5ba78	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - 10V, Positive	splash10-0006-0100900000-d5b51af9c9e096503197	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-0900400000-3410bfae1c82b5e08999	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-00b9-9434300000-661dad8f3e9cd9b10a38	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-0udi-0000009000-c84788b57e1d68c3a299	JSpectraViewer \| MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-0910510000-30a5518df6f0f53ad7b7	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-0910000000-48aef418f3aa94cc35f8	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0udi-1900000000-438261daf883fac47d6c	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0udi-1901325000-e5d0bcd5db4a59b606f8	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0udi-1901100000-a8c00836fd0ca5a71ad1	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0pdl-3900000000-358726d071759c859d9e	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0udi-0000009000-3f663b5fce4f431e1e25	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0udi-4701986000-bb5e3a66be23d7de55e6	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-05i0-3911810000-ee275d8a12bcf1e5065c	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-0900002000-37d2f661727ecc1c915a	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-0900001000-de8f3c7c7e6a620f0e90	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0udr-2930000000-7a0fc600f843201b86c4	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer

References

References:

UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). "BRENDA, the enzyme information system in 2011." Nucleic Acids Res 39:D670-D676.21062828
Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
Romero, P. A., Lussier, M., Sdicu, A. M., Bussey, H., Herscovics, A. (1997). "Ktr1p is an alpha-1,2-mannosyltransferase of Saccharomyces cerevisiae. Comparison of the enzymic properties of soluble recombinant Ktr1p and Kre2p/Mnt1p produced in Pichia pastoris." Biochem J 321 ( Pt 2):289-295.9020857
Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
Lobsanov, Y. D., Romero, P. A., Sleno, B., Yu, B., Yip, P., Herscovics, A., Howell, P. L. (2004). "Structure of Kre2p/Mnt1p: a yeast alpha1,2-mannosyltransferase involved in mannoprotein biosynthesis." J Biol Chem 279:17921-17931.14752117
Funato, K., Vallee, B., Riezman, H. (2002). "Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae." Biochemistry 41:15105-15114.12484746
Lussier, M., Sdicu, A. M., Camirand, A., Bussey, H. (1996). "Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family." J Biol Chem 271:11001-11008.8631921
Boer, V. M., Crutchfield, C. A., Bradley, P. H., Botstein, D., Rabinowitz, J. D. (2010). "Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations." Mol Biol Cell 21:198-211.19889834

Synthesis Reference:

Huang, Gang-Liang; Liu, Xiang; Zhang, Hou-Cheng; Wang, Peng-George. A facile two-step chemo-enzymatic synthesis of GDP-mannose. Letters in Organic Chemistry (2006), 3(9), 668-669.

External Links:

Resource	Link
CHEBI ID	15820
HMDB ID	HMDB01163
Pubchem Compound ID	732
Kegg ID	C00096
ChemSpider ID	24608058
FOODB ID	FDB030881
Wikipedia	Guanosine diphosphate mannose
BioCyc ID	GDP-MANNOSE

Enzymes

Protein Details

1. Dolichol-phosphate mannosyltransferase

General function:: Cell wall/membrane/envelope biogenesis
Specific function:: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins
Gene Name:: DPM1
Uniprot ID:: P14020
Molecular weight:: 30362.0

Reactions

GDP-mannose + dolichyl phosphate → GDP + dolichyl D-mannosyl phosphate.

Protein Details

2. Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2

General function:: Involved in enzyme regulator activity
Specific function:: Required for calcium regulation. May regulate calcium accumulation by a non-vacuole organelle. Also regulates the activity of CSH1 and SUR1 during mannosyl phosphorylinositol ceramide synthesis
Gene Name:: CSG2
Uniprot ID:: P35206
Molecular weight:: 45441.60156

Reactions

Protein Details

3. Chitobiosyldiphosphodolichol beta-mannosyltransferase

General function:: Involved in biosynthetic process
Specific function:: Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER
Gene Name:: ALG1
Uniprot ID:: P16661
Molecular weight:: 51928.5

Reactions

GDP-mannose + chitobiosyldiphosphodolichol → GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.

Protein Details

4. Glycolipid 2-alpha-mannosyltransferase

General function:: Involved in mannosyltransferase activity
Specific function:: Required for the attachment of the third mannose residue of O-linked saccharides
Gene Name:: KRE2
Uniprot ID:: P27809
Molecular weight:: 51386.19922

Reactions

Protein Details

5. Alpha-1,2 mannosyltransferase KTR1

General function:: Involved in mannosyltransferase activity
Specific function:: Mannosyltransferase that transfers a mannose residue from GDP-mannose to a range of acceptors in vitro
Gene Name:: KTR1
Uniprot ID:: P27810
Molecular weight:: 46021.69922

Reactions

Protein Details

6. Probable mannosyltransferase KTR2

General function:: Involved in mannosyltransferase activity
Specific function:: Involved in N-linked glycosylation
Gene Name:: KTR2
Uniprot ID:: P33550
Molecular weight:: 50650.89844

Reactions

Protein Details

7. Probable mannosyltransferase KTR3

General function:: Involved in mannosyltransferase activity
Specific function:: Possible glycosyltransferase
Gene Name:: KTR3
Uniprot ID:: P38130
Molecular weight:: 47482.0

Reactions

Protein Details

8. Probable mannosyltransferase YUR1

General function:: Involved in mannosyltransferase activity
Specific function:: Possible glycosyltransferase involved in N-linked glycosylation
Gene Name:: YUR1
Uniprot ID:: P26725
Molecular weight:: 50835.60156

Reactions

Protein Details

9. Mannose-1-phosphate guanyltransferase

General function:: Involved in transferase activity
Specific function:: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell- size checkpoint
Gene Name:: MPG1
Uniprot ID:: P41940
Molecular weight:: 39565.60156

Reactions

GTP + alpha-D-mannose 1-phosphate → diphosphate + GDP-mannose.

Protein Details

10. Alpha-1,3-mannosyltransferase ALG2

General function:: Cell wall/membrane/envelope biogenesis
Specific function:: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate
Gene Name:: ALG2
Uniprot ID:: P43636
Molecular weight:: 58046.5

Reactions

Protein Details

11. GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

General function:: protein glycosylation
Specific function:: Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum.
Gene Name:: ALG11
Uniprot ID:: P53954
Molecular weight:: 63142.705

Reactions

Transporters

Protein Details

1. GDP-mannose transporter 1

General function:: Involved in transmembrane transport
Specific function:: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity
Gene Name:: VRG4
Uniprot ID:: P40107
Molecular weight:: 37018.30078

Structure for #<Compound:0xb0c0f714>

Enzymes

Reactions

Reactions

Reactions

Reactions

Reactions

Reactions

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Reactions

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Reactions

Reactions

Transporters