{"ymdb_id":"YMDB00193","created_at":"2011-05-29T16:05:37.000Z","updated_at":"2016-09-08T18:35:09.000Z","name":"Nicotinic acid mononucleotide","cas":"321-02-8","state":"Solid","melting_point":"","description":"Nicotinic acid mononucleotide (NaMN) is an intermediate in the metabolism of nicotinate and nicotinamide. The phosphate-responsive signaling pathway, which has a role controlling NAD metabolism, responds to depletion of cellular nicotinic acid mononucleotide.  [PMID: 21349851]","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"mitochondrion;cytoplasm","synthesis_reference":null,"chebi_id":"15763","hmdb_id":"HMDB01132","kegg_id":"C01185","pubchem_id":"121991","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":"NICOTINATE_NUCLEOTIDE","iupac":"3-carboxy-1-[(2R,3R,4S,5R)-5-[(hydrogen phosphonatooxy)methyl]-3,4-dihydroxyoxolan-2-yl]-2,3-dihydro-1λ⁵-pyridin-1-ylium","traditional_iupac":"3-carboxy-1-[(2R,3R,4S,5R)-5-[(hydrogen phosphonatooxy)methyl]-3,4-dihydroxyoxolan-2-yl]-2,3-dihydro-1λ⁵-pyridin-1-ylium","logp":"-5.521236776138411","pka":"4.079195997844857","alogps_solubility":"9.83e+00 g/l","alogps_logp":"0.18","alogps_logs":"-1.60","acceptor_count":"8","donor_count":"4","rotatable_bond_count":"5","polar_surface_area":"159.58999999999997","refractivity":"80.90999999999998","polarizability":"28.692880556852675","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.731629293503155","pka_strongest_acidic":"1.2125065696226747","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["3-carboxy-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt","3-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-Pyridinium inner salt","3-carboxy-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt","3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt","3-Carboxy-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt","3-Pyridinecarboxylic acid mononucleotide","Beta-nicotinate D-ribonucleotide","beta-Nicotinic acid mononucleotide","Deamido nicotinamide ribonucleotide","deamido-nicotinamide mononucleotide","Deamido-NMN","NaMN","Nicotinate D-ribonucleoside","Nicotinate D-ribonucleotide","Nicotinate mononucleotide","nicotinate nucleotide","nicotinate ribonucleotide","nicotinate-D-ribonucleotide","nicotinate-delta-ribonucleotide","Nicotinic acid mononucleotide","Nicotinic acid ribonucleotide","Nicotinic acid ribotide","Nicotinic mononucleotide"],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21729004,"citation":"de Figueiredo, L. F., Gossmann, T. I., Ziegler, M., Schuster, S. (2011). \"Pathway Analysis of NAD+ metabolism.\" Biochem J :."},{"pubmed_id":21349851,"citation":"Lu, S. P., Lin, S. J. (2011). \"Phosphate-responsive signaling pathway is a novel component of NAD+ metabolism in Saccharomyces cerevisiae.\" J Biol Chem 286:14271-14281."}],"proteins":[{"created_at":"2011-05-26T17:48:34.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Nicotinate-nucleotide pyrophosphorylase [carboxylating]","uniprot_id":"P43619","uniprot_name":"NADC_YEAST","enzyme":true,"transporter":false,"gene_name":"BNA6","num_residues":295,"molecular_weight":"32364.69922","theoretical_pi":"5.64","general_function":"Involved in catalytic activity","specific_function":"Involved in the catabolism of quinolinic acid (QA)","reactions":[{"id":1780,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2484,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4180,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006480","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"BNA6","chromosome_location":"chromosome 6","locus":"YFR047C","synonyms":["Quinolinate phosphoribosyltransferase [decarboxylating]","QAPRTase"],"enzyme_classes":["2.4.2.19"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" nicotinate-nucleotide diphosphorylase (carboxylating) activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pyridine nucleotide biosynthetic process"},{"category":"Process","description":" nicotinamide nucleotide biosynthetic process"},{"category":"Process","description":" NAD biosynthetic process"}],"pfams":[{"name":"QRPTase_C","identifier":"PF01729"},{"name":"QRPTase_N","identifier":"PF02749"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCTGTTTATGAACACTTATTGCCCGTTAATGGAGCATGGAGACAAGACGTCACCAATTGGCTGAGCGAGGACGTTCCTTCTTTTGATTTTGGTGGATATGTTGTTGGTTCCGACCTAAAGGAGGCCAATTTGTACTGTAAGCAGGATGGTATGCTGTGTGGTGTCCCCTTTGCGCAAGAAGTCTTTAATCAGTGCGAATTGCAAGTTGAGTGGTTGTTTAAGGAAGGCTCCTTCTTGGAGCCTTCGAAGAATGACTCTGGTAAGATTGTTGTAGCTAAAATTACTGGGCCCGCTAAAAACATTCTATTAGCTGAAAGAACCGCCTTGAACATCCTTAGTAGAAGTAGTGGAATTGCCACCGCCTCACATAAGATAATCAGTTTGGCGCGTTCGACTGGTTACAAGGGGACCATTGCGGGGACAAGAAAGACTACACCAGGTTTACGTAGATTAGAAAAGTATTCCATGCTTGTAGGTGGCTGCGACACGCACAGATACGACCTTTCCTCTATGGTCATGCTCAAAGATAATCATATTTGGGCTACTGGTTCTATAACAAACGCAGTTAAGAACGCCAGGGCCGTGTGCGGGTTTGCTGTGAAGATCGAAGTGGAGTGTTTGAGTGAAGATGAAGCCACAGAGGCCATTGAAGCTGGTGCAGACGTTATCATGTTGGATAATTTCAAAGGTGACGGTTTGAAAATGTGCGCCCAAAGTCTTAAGAACAAATGGAATGGTAAAAAGCATTTCCTCTTGGAATGTAGTGGAGGCTTGAATTTGGACAACCTCGAGGAGTATTTGTGCGATGACATTGACATTTACAGCACTAGTAGCATTCATCAAGGCACACCAGTGATTGATTTCTCATTGAAACTGGCTCATTGA","protein_sequence":"MPVYEHLLPVNGAWRQDVTNWLSEDVPSFDFGGYVVGSDLKEANLYCKQDGMLCGVPFAQEVFNQCELQVEWLFKEGSFLEPSKNDSGKIVVAKITGPAKNILLAERTALNILSRSSGIATASHKIISLARSTGYKGTIAGTRKTTPGLRRLEKYSMLVGGCDTHRYDLSSMVMLKDNHIWATGSITNAVKNARAVCGFAVKIEVECLSEDEATEAIEAGADVIMLDNFKGDGLKMCAQSLKNKWNGKKHFLLECSGGLNLDNLEEYLCDDIDIYSTSSIHQGTPVIDFSLKLAH"},{"created_at":"2011-05-26T19:26:59.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Nicotinamide riboside kinase","uniprot_id":"P53915","uniprot_name":"NRK1_YEAST","enzyme":true,"transporter":false,"gene_name":"NRK1","num_residues":240,"molecular_weight":"27689.30078","theoretical_pi":"6.68","general_function":"Involved in ATP binding","specific_function":"Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)","reactions":[{"id":1954,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2567,"direction":"\u003e","locations":null,"altext":"ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide.","export":false,"pw_reaction_id":null,"source":null},{"id":2568,"direction":"\u003e","locations":null,"altext":"ATP + D-ribosylnicotinate = ADP + nicotinate D-ribonucleotide.","export":false,"pw_reaction_id":null,"source":null},{"id":4191,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006490","source":"Smpdb"},{"id":4192,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006496","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558011","genbank_protein_id":"45269912","gene_card_id":"NRK1","chromosome_location":"chromosome 14","locus":"YNL129W","synonyms":["NRK","NmR-K","Nicotinic acid riboside kinase","Ribosylnicotinamide kinase","RNK","Ribosylnicotinic acid kinase"],"enzyme_classes":["2.7.1.22"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PRK","identifier":"PF00485"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTTCGAAAAAAGTGATATTAGTTGCATTGAGTGGATGCTCCTCCAGTGGTAAGACGACAATTGCGAAACTTACAGCAAGTTTATTCACGAAGGCTACATTAATTCATGAAGATGACTTTTACAAACATGATAATGAAGTGCCAGTAGATGCTAAATATAACATTCAAAATTGGGATTCGCCAGAAGCTCTTGATTTTAAACTTTTCGGTAAAGAATTAGATGTGATCAAACAAACTGGTAAAATAGCCACCAAACTTATACACAATAACAACGTAGATGATCCCTTTACAAAGTTCCACATTGATAGACAAGTTTGGGACGAGTTAAAGGCTAAGTATGACTCTATTAATGACGACAAATATGAAGTTGTAATTGTAGATGGGTTTATGATTTTCAATAATACTGGAATATCAAAAAAATTTGATTTGAAGATATTAGTGCGTGCTCCCTATGAAGTACTAAAAAAAAGGAGGGCTTCCAGAAAAGGATACCAGACTTTGGATTCTTTCTGGGTGGATCCGCCGTATTATTTCGACGAATTTGTGTATGAATCTTATCGTGCAAATCATGCGCAGTTATTTGTTAATGGAGACGTAGAAGGTTTACTAGACCCAAGGAAGTCAAAGAATATAAAAGAGTTCATAAATGATGATGACACTCCAATTGCGAAACCTTTAAGCTGGGTGTGCCAAGAGATTCTAAAGCTTTGTAAGGATTAG","protein_sequence":"MTSKKVILVALSGCSSSGKTTIAKLTASLFTKATLIHEDDFYKHDNEVPVDAKYNIQNWDSPEALDFKLFGKELDVIKQTGKIATKLIHNNNVDDPFTKFHIDRQVWDELKAKYDSINDDKYEVVIVDGFMIFNNTGISKKFDLKILVRAPYEVLKKRRASRKGYQTLDSFWVDPPYYFDEFVYESYRANHAQLFVNGDVEGLLDPRKSKNIKEFINDDDTPIAKPLSWVCQEILKLCKD"},{"created_at":"2011-05-26T19:37:07.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"Nicotinamide-nucleotide adenylyltransferase 2","uniprot_id":"P53204","uniprot_name":"NMA2_YEAST","enzyme":true,"transporter":false,"gene_name":"NMA2","num_residues":395,"molecular_weight":"44908.69922","theoretical_pi":"5.75","general_function":"Involved in nucleotidyltransferase activity","specific_function":"ATP + nicotinamide ribonucleotide = diphosphate + NAD(+);ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+","reactions":[{"id":1777,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1779,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2581,"direction":"\u003e","locations":"Nucleus","altext":"ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).","export":false,"pw_reaction_id":null,"source":null},{"id":2582,"direction":"\u003e","locations":"Nucleus","altext":"ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+","export":false,"pw_reaction_id":null,"source":null},{"id":4181,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006483","source":"Smpdb"},{"id":4182,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006491","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"Z72795","genbank_protein_id":"1322971","gene_card_id":"NMA2","chromosome_location":"chromosome 7","locus":"YGR010W","synonyms":["NAD(+) diphosphorylase 2","NAD(+) pyrophosphorylase 2","NMN adenylyltransferase 2"],"enzyme_classes":["2.7.7.1","2.7.7.18"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pyridine nucleotide biosynthetic process"},{"category":"Process","description":" nicotinamide nucleotide biosynthetic process"},{"category":"Process","description":" NAD biosynthetic process"}],"pfams":[{"name":"CTP_transf_2","identifier":"PF01467"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGGATCCCACCAAAGCACCCGATTTTAAACCGCCACAGCCAAATGAAGAACTACAACCACCGCCAGATCCAACACATACGATACCAAAATCTGGACCCATAGTTCCATATGTTTTAGCTGATTATAATTCTTCGATCGATGCTCCTTTCAATCTCGACATTTACAAAACCCTGTCGTCAAGGAAAAAAAACGCCAACTCAAGCAACCGAATGGACCATATTCCATTAAATACTAGTGACTTCCAGCCACTATCTCGGGATGTATCATCGGAGGAGGAAAGTGAAGGGCAATCGAATGGAATTGACGCTACTCTACAGGATGTTACGATGACTGGGAATTTGGGGGTACTGAAGAGCCAAATTGCTGATTTGGAAGAAGTTCCTCACACAATTGTAAGACAAGCCAGAACTATTGAAGATTACGAATTTCCTGTACACAGATTGACGAAAAAGTTACAAGATCCTGAAAAACTGCCTCTGATCATCGTTGCTTGTGGATCATTTTCTCCCATAACATACCTACATTTGAGAATGTTTGAAATGGCTTTAGATGATATCAATGAGCAAACGCGTTTTGAAGTGGTTGGTGGTTATTTTTCTCCAGTAAGTGATAACTATCAAAAGCGAGGGTTAGCCCCAGCTTATCATCGTGTCCGCATGTGCGAATTAGCATGCGAGCGGACATCATCTTGGTTAATGGTTGATGCCTGGGAATCTTTACAATCAAGTTATACAAGGACAGCAAAAGTCTTGGACCATTTCAATCATGAAATAAATATCAAGAGAGGTGGAATCATGACTGTAGATGGTGAAAAAATGGGCGTAAAAATCATGTTATTGGCAGGCGGTGATCTTATCGAATCCATGGGCGAGCCTCATGTGTGGGCTGATTCAGACCTGCACCATATTTTGGGTAATTATGGATGTTTGATCGTGGAAAGGACTGGTTCTGATGTTAGGTCCTTCTTGCTTTCCCATGATATCATGTATGAACACAGAAGAAATATCCTTATTATCAAACAACTTATTTACAATGATATTTCCTCTACGAAAGTGCGGCTTTTCATCAGACGTGGAATGTCAGTTCAATATCTTCTTCCAAACTCTGTCATCCGTTACATCCAAGAGTATAATCTATACATTAATCAAAGTGAACCGGTCAAGCAGGTCTTGGATAGCAAAGAGTGA","protein_sequence":"MDPTKAPDFKPPQPNEELQPPPDPTHTIPKSGPIVPYVLADYNSSIDAPFNLDIYKTLSSRKKNANSSNRMDHIPLNTSDFQPLSRDVSSEEESEGQSNGIDATLQDVTMTGNLGVLKSQIADLEEVPHTIVRQARTIEDYEFPVHRLTKKLQDPEKLPLIIVACGSFSPITYLHLRMFEMALDDINEQTRFEVVGGYFSPVSDNYQKRGLAPAYHRVRMCELACERTSSWLMVDAWESLQSSYTRTAKVLDHFNHEINIKRGGIMTVDGEKMGVKIMLLAGGDLIESMGEPHVWADSDLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYNDISSTKVRLFIRRGMSVQYLLPNSVIRYIQEYNLYINQSEPVKQVLDSKE"},{"created_at":"2011-05-26T20:11:17.000Z","updated_at":"2011-05-27T15:01:08.000Z","name":"Nicotinamide-nucleotide adenylyltransferase 1","uniprot_id":"Q06178","uniprot_name":"NMA1_YEAST","enzyme":true,"transporter":false,"gene_name":"NMA1","num_residues":401,"molecular_weight":"45858.60156","theoretical_pi":"6.89","general_function":"Involved in nucleotidyltransferase activity","specific_function":"ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)","reactions":[{"id":1778,"direction":"\u003c\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1779,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2581,"direction":"\u003e","locations":"Nucleus","altext":"ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).","export":false,"pw_reaction_id":null,"source":null},{"id":4181,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006483","source":"Smpdb"},{"id":4182,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006491","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U20618","genbank_protein_id":"662140","gene_card_id":"NMA1","chromosome_location":"chromosome 12","locus":"YLR328W","synonyms":["NAD(+) diphosphorylase 1","NAD(+) pyrophosphorylase 1","NMN adenylyltransferase 1"],"enzyme_classes":["2.7.7.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pyridine nucleotide biosynthetic process"},{"category":"Process","description":" nicotinamide nucleotide biosynthetic process"},{"category":"Process","description":" NAD biosynthetic process"}],"pfams":[{"name":"CTP_transf_2","identifier":"PF01467"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGGATCCCACAAGAGCTCCGGATTTCAAACCGCCATCTGCAGACGAGGAATTGATTCCTCCACCCGACCCGGAATCTAAAATTCCCAAATCTATTCCAATTATTCCATACGTCTTAGCCGATGCGAATTCCTCTATAGATGCACCTTTTAATATTAAGAGGAAGAAAAAGCATCCTAAGCATCATCATCACCATCATCACAGTCGTAAAGAAGGCAATGATAAAAAACATCAGCATATTCCATTGAACCAAGACGACTTTCAACCACTTTCCGCAGAAGTGTCTTCCGAAGATGATGACGCGGATTTTAGATCCAAGGAGAGATACGGTTCAGATTCAACCACAGAATCAGAAACTAGAGGTGTTCAGAAATATCAGATTGCTGATTTAGAAGAAGTTCCACATGGAATCGTTCGTCAAGCAAGAACCTTGGAAGACTACGAATTCCCCTCACACAGATTATCGAAAAAATTACTGGATCCAAATAAACTGCCGTTAGTAATAGTAGCATGTGGGTCTTTTTCACCAATCACCTACTTGCATCTAAGAATGTTTGAAATGGCTTTAGATGCAATCTCTGAACAAACAAGGTTTGAAGTCATAGGTGGATATTACTCCCCTGTTAGTGATAACTATCAAAAGCAAGGCTTGGCCCCATCCTACCATAGAGTACGTATGTGTGAATTGGCCTGCGAAAGAACCTCATCTTGGTTGATGGTGGATGCATGGGAGTCATTGCAACCTTCATACACAAGAACTGCCAAGGTCTTGGATCATTTCAATCACGAAATCAATATTAAGAGAGGTGGTGTAGCTACTGTTACTGGAGAAAAAATTGGTGTGAAAATAATGTTGCTGGCTGGTGGTGACCTAATAGAGTCAATGGGTGAACCAAACGTTTGGGCGGACGCCGATTTACATCACATTCTCGGTAATTACGGTTGTTTGATTGTCGAACGTACTGGTTCTGATGTAAGGTCTTTTTTGTTATCCCATGATATTATGTATGAACATAGAAGGAATATTCTTATCATCAAGCAACTCATCTATAATGATATTTCTTCCACGAAAGTTCGTCTATTTATCAGACGCGCCATGTCTGTACAATATTTGTTACCTAATTCGGTCATCAGGTATATCCAAGAACATAGACTATATGTGGACCAAACCGAACCTGTTAAGCAAGTTCTTGGAAACAAAGAATGA","protein_sequence":"MDPTRAPDFKPPSADEELIPPPDPESKIPKSIPIIPYVLADANSSIDAPFNIKRKKKHPKHHHHHHHSRKEGNDKKHQHIPLNQDDFQPLSAEVSSEDDDADFRSKERYGSDSTTESETRGVQKYQIADLEEVPHGIVRQARTLEDYEFPSHRLSKKLLDPNKLPLVIVACGSFSPITYLHLRMFEMALDAISEQTRFEVIGGYYSPVSDNYQKQGLAPSYHRVRMCELACERTSSWLMVDAWESLQPSYTRTAKVLDHFNHEINIKRGGVATVTGEKIGVKIMLLAGGDLIESMGEPNVWADADLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYNDISSTKVRLFIRRAMSVQYLLPNSVIRYIQEHRLYVDQTEPVKQVLGNKE"},{"created_at":"2011-05-27T03:22:51.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Nicotinate phosphoribosyltransferase","uniprot_id":"P39683","uniprot_name":"NPT1_YEAST","enzyme":true,"transporter":false,"gene_name":"NPT1","num_residues":429,"molecular_weight":"49018.19922","theoretical_pi":"6.92","general_function":"Involved in nicotinate phosphoribosyltransferase activity","specific_function":"Essential for growth under anaerobic conditions","reactions":[{"id":1768,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2722,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4193,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006492","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1VLP","cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"Z75117","genbank_protein_id":"1420489","gene_card_id":"NPT1","chromosome_location":"chromosome 15","locus":"YOR209C","synonyms":["NAPRTase"],"enzyme_classes":["2.4.2.11"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" nicotinate phosphoribosyltransferase activity"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pyridine nucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nicotinamide nucleotide biosynthetic process"},{"category":"Process","description":" NAD biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" nucleotide biosynthetic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nicotinate nucleotide biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"NAPRTase","identifier":"PF04095"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCAGAACCAGTGATAAAGTCTCTTTTGGACACAGACATGTACAAGATTACGATGCATGCTGCTGTCTTCACTAATTTTCCAGATGTTACAGTTACTTATAAATATACCAACAGGTCGTCCCAATTGACCTTCAATAAGGAAGCCATTAATTGGTTGAAAGAGCAATTTTCGTATTTGGGAAATTTGAGGTTCACAGAAGAGGAAATTGAATACTTAAAACAGGAAATCCCATATTTGCCATCGGCATATATTAAGTATATTAGCAGTTCTAATTACAAACTACACCCTGAAGAGCAGATTTCCTTCACTTCAGAAGAAATCGAGGGCAAGCCCACCCACTACAAATTGAAAATTTTAGTCAGTGGTAGTTGGAAGGATACTATCCTTTATGAGATCCCCTTACTGTCCCTAATATCAGAAGCGTATTTTAAATTTGTTGACATCGACTGGGACTACGAAAACCAATTAGAACAAGCTGAGAAGAAGGCGGAAACTTTGTTTGATAATGGTATTAGATTCAGTGAATTTGGTACAAGACGTCGTAGATCTCTGAAGGCTCAAGATCTAATTATGCAAGGAATCATGAAAGCTGTGAACGGTAACCCAGACAGAAACAAATCGCTATTATTAGGCACATCAAATATTTTATTTGCCAAGAAATATGGAGTCAAGCCAATCGGTACTGTGGCTCACGAGTGGGTTATGGGAGTCGCTTCTATTAGTGAAGATTATTTGCATGCCAATAAAAATGCAATGGATTGTTGGATCAATACTTTTGGTGCAAAAAATGCTGGTTTAGCATTAACGGATACTTTTGGAACTGATGACTTTTTAAAATCATTCCGTCCACCATATTCTGATGCTTACGTCGGTGTTAGACAAGATTCTGGAGACCCAGTTGAGTATACCAAAAAGATTTCCCACCATTACCATGACGTGTTGAAATTGCCTAAATTCTCGAAGATTATCTGTTATTCCGATTCTTTGAACGTCGAAAAGGCAATAACTTACTCCCATGCAGCTAAAGAGAATGGAATGCTAGCCACATTCGGTATTGGCACAAACTTTACTAATGATTTTCGTAAGAAGTCAGAACCCCAGGTTAAAAGTGAGCCGTTAAACATCGTTATCAAACTATTAGAAGTAAATGGTAATCACGCTATCAAAATTTCTGATAACTTAGGTAAAAATATGGGAGATCCTGCCACTGTGAAGAGAGTGAAAGAGGAATTGGGATATACTGAACGAAGTTGGAGTGGTGATAACGAAGCGCACAGATGGACCTAA","protein_sequence":"MSEPVIKSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLTFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQEIPYLPSAYIKYISSSNYKLHPEEQISFTSEEIEGKPTHYKLKILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQAEKKAETLFDNGIRFSEFGTRRRRSLKAQDLIMQGIMKAVNGNPDRNKSLLLGTSNILFAKKYGVKPIGTVAHEWVMGVASISEDYLHANKNAMDCWINTFGAKNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHDVLKLPKFSKIICYSDSLNVEKAITYSHAAKENGMLATFGIGTNFTNDFRKKSEPQVKSEPLNIVIKLLEVNGNHAIKISDNLGKNMGDPATVKRVKEELGYTERSWSGDNEAHRWT"}]}