{"ymdb_id":"YMDB00189","created_at":"2011-05-29T16:05:18.000Z","updated_at":"2016-09-08T18:35:09.000Z","name":"Beta-1,4-D-Mannosylchitobiosyldiphosphodolichol","cas":null,"state":"Solid","melting_point":"","description":"beta-1,4-D-Mannosylchitobiosyldiphosphodolichol is a lipid-linked oligosaccharide.  It is part of the N-glycan biosynthesis pathway.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"Golgi;cytoplasm","synthesis_reference":null,"chebi_id":"18396","hmdb_id":"HMDB11673","kegg_id":"C05860","pubchem_id":"24892765","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":"D-GALACTOSYL-14-D-GALACTOSYL-14-D-","iupac":"{[(2R,3R,4R,5S,6R)-3-acetamido-5-{[(2S,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-{[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}({[hydroxy({[(6E,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl]oxy})phosphoryl]oxy})phosphinic acid","traditional_iupac":"[(2R,3R,4R,5S,6R)-3-acetamido-5-{[(2S,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-{[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy({hydroxy[(6E,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl]oxyphosphoryl}oxy)phosphinic acid","logp":"1.0320905266666662","pka":"3.171781737140521","alogps_solubility":"1.55e-01 g/l","alogps_logp":"1.84","alogps_logs":"-3.85","acceptor_count":"19","donor_count":"12","rotatable_bond_count":"29","polar_surface_area":"368.4799999999999","refractivity":"262.8133000000001","polarizability":"112.14197515823128","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.52536536954484","pka_strongest_acidic":"1.7444953207900582","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["b-(1-\u003e4)-D-mannosylchitobiosyldiphosphodolichol","b-1,4-D-mannosylchitobiosyldiphosphodolichol","Beta-(1-\u003e4)-D-mannosylchitobiosyldiphosphodolichol","Beta-(1-\u003e4)-delta-mannosylchitobiosyldiphosphodolichol","beta-1,4-delta-mannosylchitobiosyldiphosphodolichol","Beta-D-mannosyldiacetylchitobiosyldiphosphodolichol","Beta-delta-mannosyldiacetylchitobiosyldiphosphodolichol","Man-beta1-\u003e4GlcNAc-beta1-\u003e4GlcNAc-PP-Dol"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."}],"proteins":[{"created_at":"2011-05-27T03:21:53.000Z","updated_at":"2011-07-22T17:54:18.000Z","name":"Chitobiosyldiphosphodolichol beta-mannosyltransferase","uniprot_id":"P16661","uniprot_name":"ALG1_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG1","num_residues":449,"molecular_weight":"51928.5","theoretical_pi":"9.07","general_function":"Involved in biosynthetic process","specific_function":"Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER","reactions":[{"id":1345,"direction":"\u003c\u003e","locations":"endoplasmic reticulum membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2721,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass type II membrane protein (Potential)","altext":"GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.","export":false,"pw_reaction_id":null,"source":null},{"id":14871,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007062","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"8-34","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass type II membrane protein (Potential)","genbank_gene_id":"J05416","genbank_protein_id":"171050","gene_card_id":"ALG1","chromosome_location":"chromosome 2","locus":"YBR110W","synonyms":["Asparagine-linked glycosylation protein 1","Beta-1,4-mannosyltransferase","GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase","GDP-mannose-dolichol diphosphochitobiose mannosyltransferase"],"enzyme_classes":["2.4.1.142"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Glycos_transf_1","identifier":"PF00534"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGTTTTTGGAAATTCCTCGGTGGTTACTTGCCTTAATAATATTATACCTTTCCATACCGTTAGTGGTTTATTATGTTATACCCTACTTGTTTTATGGCAACAAGTCGACCAAAAAAAGGATCATCATATTTGTGCTGGGTGATGTAGGACACTCTCCAAGGATATGCTATCACGCTATAAGTTTCAGTAAGTTAGGTTGGCAAGTCGAGCTATGCGGTTATGTGGAGGACACTCTACCCAAAATTATTTCCAGTGATCCAAATATCACCGTCCATCATATGTCAAACTTGAAAAGAAAGGGAGGCGGAACATCAGTTATATTTATGGTAAAGAAGGTGCTTTTTCAAGTTTTAAGTATTTTCAAATTACTTTGGGAATTGAGAGGAAGCGATTACATACTAGTTCAAAATCCACCGAGCATACCCATTCTTCCGATTGCTGTGCTATACAAGTTGACCGGTTGTAAACTAATTATTGATTGGCACAATCTAGCATATTCGATATTGCAACTAAAATTTAAAGGAAACTTTTACCATCCTTTAGTGTTGATATCTTACATGGTAGAGATGATATTCAGCAAATTTGCTGATTATAACTTGACTGTTACTGAAGCAATGAGGAAATATTTAATTCAAAGCTTTCACTTGAATCCAAAGAGATGTGCTGTTCTCTACGACCGCCCGGCTTCCCAATTTCAACCTTTGGCAGGTGACATTTCTCGTCAAAAAGCCCTAACTACCAAAGCCTTTATAAAGAATTATATTCGCGATGATTTTGATACAGAAAAAGGCGATAAAATTATTGTGACTTCAACATCATTCACCCCTGATGAAGATATTGGTATTTTATTAGGTGCCCTAAAGATTTACGAAAACTCTTATGTCAAATTTGATTCAAGTTTGCCTAAGATCTTGTGTTTTATAACGGGTAAAGGACCACTAAAGGAGAAATATATGAAGCAAGTAGAAGAATATGACTGGAAGCGCTGTCAAATCGAATTTGTGTGGTTGTCAGCAGAGGATTACCCAAAGTTATTACAATTATGCGATTACGGAGTTTCCCTGCATACTTCAAGTTCAGGGTTGGACCTGCCAATGAAAATTTTAGATATGTTTGGCTCAGGTCTTCCTGTTATTGCAATGAACTATCCAGTGCTTGACGAATTAGTACAACACAATGTAAATGGGTTAAAATTTGTTGATAGAAGGGAGCTTCATGAATCTCTGATTTTTGCTATGAAAGATGCTGATTTATACCAAAAATTGAAGAAAAATGTAACGCAGGAAGCTGAGAACAGATGGCAATCAAATTGGGAACGAACAATGAGAGATTTGAAGCTAATTCATTGA","protein_sequence":"MFLEIPRWLLALIILYLSIPLVVYYVIPYLFYGNKSTKKRIIIFVLGDVGHSPRICYHAISFSKLGWQVELCGYVEDTLPKIISSDPNITVHHMSNLKRKGGGTSVIFMVKKVLFQVLSIFKLLWELRGSDYILVQNPPSIPILPIAVLYKLTGCKLIIDWHNLAYSILQLKFKGNFYHPLVLISYMVEMIFSKFADYNLTVTEAMRKYLIQSFHLNPKRCAVLYDRPASQFQPLAGDISRQKALTTKAFIKNYIRDDFDTEKGDKIIVTSTSFTPDEDIGILLGALKIYENSYVKFDSSLPKILCFITGKGPLKEKYMKQVEEYDWKRCQIEFVWLSAEDYPKLLQLCDYGVSLHTSSSGLDLPMKILDMFGSGLPVIAMNYPVLDELVQHNVNGLKFVDRRELHESLIFAMKDADLYQKLKKNVTQEAENRWQSNWERTMRDLKLIH"}]}