{"ymdb_id":"YMDB00184","created_at":"2011-05-29T16:04:48.000Z","updated_at":"2016-09-08T18:35:09.000Z","name":"di-trans,poly-cis-Decaprenyl diphosphate","cas":null,"state":null,"melting_point":null,"description":"Di-trans,poly-cis-Decaprenyl diphosphate is a prenol lipid, specifically an isoprenoid-disphosphate. Prenol lipids are synthesized from the 5-carbon precursors isopentenyl diphosphate and dimethylallyl diphosphate that are produced mainly via the mevalonic acid pathway. Simple isoprenoids like Di-trans,poly-cis-Decaprenyl diphosphate are formed by the successive addition of C5 units.[Wikipedia] It is involved in di-trans,poly-cis-undecaprenyl phosphate biosynthesis pathway.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Endoplasmic Reticulum, Lipid Particle, Plasma membrane","synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":"C04509","pubchem_id":"24892750","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"[({[(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid","traditional_iupac":"{[(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]oxy(hydroxy)phosphoryl}oxyphosphonic acid","logp":"15.234732985666664","pka":"3.1843406094078315","alogps_solubility":"3.23e-04 g/l","alogps_logp":"8.90","alogps_logs":"-6.43","acceptor_count":"5","donor_count":"3","rotatable_bond_count":"32","polar_surface_area":"113.28999999999999","refractivity":"263.34870000000006","polarizability":"101.54633710706271","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":null,"pka_strongest_acidic":"1.7672186885241006","bioavailability":"0","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["ditrans,heptacis-Decaprenyl diphosphate"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."}],"proteins":[{"created_at":"2011-05-27T03:20:29.000Z","updated_at":"2011-05-29T05:06:38.000Z","name":"Probable undecaprenyl pyrophosphate synthase","uniprot_id":"Q12063","uniprot_name":"UPPS_YEAST","enzyme":true,"transporter":false,"gene_name":"NUS1","num_residues":375,"molecular_weight":"42556.69922","theoretical_pi":"6.95","general_function":"Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups","specific_function":"Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP)","reactions":[{"id":2719,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Lipid droplet. Nucleus membrane; Single-pass membrane protein (Potential)","altext":"(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14431,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006945","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"97-119","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Lipid droplet. Nucleus membrane; Single-pass membrane protein (Potential)","genbank_gene_id":"X83276","genbank_protein_id":"1004302","gene_card_id":"NUS1","chromosome_location":"chromosome 4","locus":"YDL193W","synonyms":["UPP synthase","Di-trans,poly-cis-decaprenylcistransferase","Nuclear undecaprenyl pyrophosphate synthase 1","Undecaprenyl diphosphate synthase","UDS"],"enzyme_classes":["2.5.1.31"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[],"pathways":[{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"}],"gene_sequence":"ATGCCCACGATGATCAAAAAGGATGATAAAGCAATGGAGCCCCCTAATGAAAAACCGCATAGAAAGATCGAAAGAGATGATGTTCCAGAATCTTCCAATCACATCCCACCTCCAGAATCTGGTGTTTTAAAGGGCGGTAAAGTTAATTCAAAAACCAGAGCTTTAAAGGCCGTTACAAGTATCATTGCAGACGCCGATGAGAACCCTCAGAAGAAAGTGAACAATGAGACGAATGGAGTCCAAAAGCAAAAGACAGAAGATTTGAGTAAAAGAATAGGTAAATTTGAATACCTTTTTTACAAGTTTTTACTTGTGTTGTTATACATCTGCTTCGGGTTGTTTCGGTACGGTCAATACCAATATAATAAAATGAAACTAAGAATATTCAGTATCATCTACAACCATGCATATACACCACAGTTGATTAGACAGGACGTTATTCCTCTGAAAAAAATTCCTAAAAGGTTGGCCGCTATCTTGGAAGTCAAGCCAGTTGGCGACGTTGGCGGCGGTGTGACAGGTTTATTAAATGACGCGAGTGAAATTGTTTGCTGGACTGTTTCAGCTGGTATAAAACATTTGATGTTGTACGATTACGATGGAATATTACAAAGAAATGTTCCAGAGCTGAGAATGGAAATTCATTCCAACCTGGCTAAATATTTTGGGCCAGCTCATGTTCCAAACTACGCTGTTAAAATACCTCATTCTAACAAGATATTCTACAATCTAGACGGAATTGAAACCGAGACTGATGTAGGCAATGAGATAGAAGCTAACCAAGAAAAGGACAAAATTGCTATTGAAATTTCTTTATTGTCTAACAGAGATGGTAGAGAAACGATTGTCGATCTGACCAAAACTATGGCTGAGTTATGTGCGGTTAACGAATTGAGCGTTTCTGACATCACAATGGATTTAGTTGATTCAGAACTGAAACAACTAGTTGGACCCGAACCAGATTTACTGTTATACTTCGGGCCTTCGTTGGATTTACAAGGGTTCCCACCTTGGCATATTAGATTAACCGAATTTTATTGGGAAAAAGATAACAACGAAGTCATATATTCGGTTTTCATCCGCGGCCTAAGACAGTACGCAGGATGTAAAGTGAATGTTGGTAAATGA","protein_sequence":"MPTMIKKDDKAMEPPNEKPHRKIERDDVPESSNHIPPPESGVLKGGKVNSKTRALKAVTSIIADADENPQKKVNNETNGVQKQKTEDLSKRIGKFEYLFYKFLLVLLYICFGLFRYGQYQYNKMKLRIFSIIYNHAYTPQLIRQDVIPLKKIPKRLAAILEVKPVGDVGGGVTGLLNDASEIVCWTVSAGIKHLMLYDYDGILQRNVPELRMEIHSNLAKYFGPAHVPNYAVKIPHSNKIFYNLDGIETETDVGNEIEANQEKDKIAIEISLLSNRDGRETIVDLTKTMAELCAVNELSVSDITMDLVDSELKQLVGPEPDLLLYFGPSLDLQGFPPWHIRLTEFYWEKDNNEVIYSVFIRGLRQYAGCKVNVGK"}]}