{"ymdb_id":"YMDB00174","created_at":"2011-05-29T16:03:51.000Z","updated_at":"2016-09-08T18:35:08.000Z","name":"2-Hexaprenyl-6-methoxy-1,4-benzoquinone","cas":null,"state":"Solid","melting_point":"","description":"2-Hexaprenyl-6-methoxy-1,4-benzoquinone is involved in the ubiquinone biosynthesis pathway.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"mitochondrion","synthesis_reference":null,"chebi_id":"27752","hmdb_id":"HMDB06818","kegg_id":"C05803","pubchem_id":"958","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":"2-HEXAPRENYL-6-METHOXY-14-BENZOQUINOL","iupac":"2-[(2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-6-methoxycyclohexa-2,5-diene-1,4-dione","traditional_iupac":"2-[(2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-6-methoxycyclohexa-2,5-diene-1,4-dione","logp":"10.527550993666667","pka":null,"alogps_solubility":"3.63e-04 g/l","alogps_logp":"8.41","alogps_logs":"-6.18","acceptor_count":"3","donor_count":"0","rotatable_bond_count":"18","polar_surface_area":"43.370000000000005","refractivity":"180.31910000000002","polarizability":"69.03625491842524","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-4.941427837132697","pka_strongest_acidic":null,"bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-polyprenyl-6-methoxy-1,4-benzoquinol","DDMQH2"],"pathways":[{"name":"Ubiquinone and other terpenoid-quinone biosynthesis","kegg_map_id":"00130"},{"name":"Ubiquinone Biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":15792955,"citation":"Marbois, B., Gin, P., Faull, K. F., Poon, W. W., Lee, P. T., Strahan, J., Shepherd, J. N., Clarke, C. F. (2005). \"Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.\" J Biol Chem 280:20231-20238."}],"proteins":[{"created_at":"2011-05-27T02:37:10.000Z","updated_at":"2011-05-29T05:06:36.000Z","name":"Ubiquinone biosynthesis protein COQ4, mitochondrial","uniprot_id":"O13525","uniprot_name":"COQ4_YEAST","enzyme":true,"transporter":false,"gene_name":"COQ4","num_residues":335,"molecular_weight":"38626.80078","theoretical_pi":"10.13","general_function":"Involved in ubiquinone biosynthetic process","specific_function":"Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides","reactions":[],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"Z68194","genbank_protein_id":"1204149","gene_card_id":"COQ4","chromosome_location":"chromosome 4","locus":"YDR204W","synonyms":["Coenzyme Q biosynthesis protein 4"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" oxidoreduction coenzyme metabolic process"},{"category":"Process","description":" ubiquinone metabolic process"},{"category":"Process","description":" ubiquinone biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"}],"pfams":[{"name":"Coq4","identifier":"PF05019"}],"pathways":[],"gene_sequence":"ATGTTGAGGTTATCTTTACTGAGATCAACAGCTACTTTGCCAGTGAAATGCCAACGTCGTGGGCTAATATTACCTGCGGCGGCAATGTACACCTTAGGCTCATTAATATTTGGTAAGGAAGCAAGGTTGGCGGATGCCATGGAACGTGGTGAGTTACATAACAAGAACGTTGATTATGCGAAAGAAGCTGAAGAGCGTACCGAGTTACGTATTAGGGCCCTGGCTAATACTCGGCCAATGGAACCTCGGTACAACGGCCATGTTCCCCTTCATCGGTACGAGAAATTGCTGCTGTTTGCAATTTCCGGTTGGAATTCATTTTTCCATCCTGAAGATGGTTATAATATTGTACAATTGGGTGAGGCAACTGCATTGCCGGTCTTCTTGGAGAATTTGAAGCAAACAATGTTAAGTGATTCCTCTGGGAGGCGCATTTTGAAGGAACAACCCAATATCACAACAGAGATTTTGCATATGGACAAACTAGCTAAATTGCCACATAACACGTTTGGGTATGTATATTACCAATGGTTGAAAAGAGAAAACGTTTCTCCGGACACTAGAGCACCTGTCAAATTTATCGACGATCCTATGCATGCATATATCTTTAAGAGGTATAGACAATGCCACGATTTCTATCACGCTATAACCAACATGCCTATTATCATTGAGGGGGAGATCACCATAAAGGCTCTTGAAGGTGCCAACCTGGGCGTCCCAATGGCCATTCTCGGTGGTATCCTTGCACCTTTACGTTTGAAAAAGGTGCAAAGAAAAAGATTATATAATATATATCTCCCTTGGGCTGTCAGAACAGGTTTAAGCTGCAAGCCATTGATCAACGTGTATTGGGAGGAAATGCTGGAGAAGGATGTTACTGCTTTGAGGAAAGAGCTAAAGATAACACTCCCTCCGGATCTAAGGACAATGAGGAAGGAGCGTGCAGCCCTTAGGAAGGAGATTGACGCAAAATACAACTCACAGAAACGAGCCACGACTCCAGCATGA","protein_sequence":"MLRLSLLRSTATLPVKCQRRGLILPAAAMYTLGSLIFGKEARLADAMERGELHNKNVDYAKEAEERTELRIRALANTRPMEPRYNGHVPLHRYEKLLLFAISGWNSFFHPEDGYNIVQLGEATALPVFLENLKQTMLSDSSGRRILKEQPNITTEILHMDKLAKLPHNTFGYVYYQWLKRENVSPDTRAPVKFIDDPMHAYIFKRYRQCHDFYHAITNMPIIIEGEITIKALEGANLGVPMAILGGILAPLRLKKVQRKRLYNIYLPWAVRTGLSCKPLINVYWEEMLEKDVTALRKELKITLPPDLRTMRKERAALRKEIDAKYNSQKRATTPA"},{"created_at":"2011-05-27T03:11:11.000Z","updated_at":"2011-05-29T05:06:37.000Z","name":"Ubiquinone biosynthesis methyltransferase COQ5, mitochondrial","uniprot_id":"P49017","uniprot_name":"COQ5_YEAST","enzyme":true,"transporter":false,"gene_name":"COQ5","num_residues":307,"molecular_weight":"34684.19922","theoretical_pi":"6.52","general_function":"Involved in methyltransferase activity","specific_function":"Converts DDMQH2 into DMQH2","reactions":[{"id":2709,"direction":"\u003e","locations":"Mitochondrion","altext":"S-adenosyl-L-methionine + 2-polyprenyl-6-methoxy-1,4-benzoquinol = S-adenosyl-L-homocysteine + 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY693194","genbank_protein_id":"51013839","gene_card_id":"COQ5","chromosome_location":"chromosome 13","locus":"YML110C","synonyms":[],"enzyme_classes":["2.1.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Ubie_methyltran","identifier":"PF01209"}],"pathways":[],"gene_sequence":"ATGTTGATTTCTTCACGGATCGTTCGAAGCTCGCTGGTAAATGTCCCGCTAAGATTATCTAGGTGTTTTACGCAAGCTCACAGAGCATGCAAAGAAGAAGAAGTTAATAGTCCTTTATCATCCGCAGCTGAACAGCCAGAGCAGAAGTATACGCATTTTGGTTCGAAGACTGTATTGAAGTCTACCAAGCAGAAGTTAGTTGGTGATGTCTTTTCTTCCGTGGCCAATCGGTATGACTTGATGAATGATGTTATGTCATTAGGAATTCATAGATTGTGGAAGGACCATTTTATCAATAAACTAGATGCGGGAAAAAGGCCAAACTCTACGACTCCTTTGAACTTCATAGATGTGGCTGGGGGATCCGGTGATATTGCTTTCGGATTACTAGACCATGCTGAGTCGAAATTTGGTGACACTGAGTCTACAATGGATATTGTAGATATCAACCCTGACATGCTTAAAGAAGGTGAGAAGAGAGCCATGGAGCAAGGAAAATATTTCAAGGATCCTCGTGTGAGATTTTTGGTTTCTAATGGTGAGAAACTAGAGGAGATTGATTCTGATTCCAAGGACATCTACACAGTCTCCTTCGGTATCAGAAATTTCACCGATATTCAAAAGGGTTTAAACACTGCTTATAGAGTTTTGAAACCGGGCGGTATTTTTTATTGTCTAGAATTTTCCAAAATTGAGAATCCCCTAATGGACTTTGCTTACCAACAGTGGGCTAAGGTCCTACCTGTAATGGGCTCGATGATTGCTAATGACTACGACTCTTACCAGTATTTGGTGGAGTCTATCGAAAGATTTCCTGACCAAGAAACGTTCAAATCCATGATTGAGAAGGCAGGATTCAAATCTGCTGGCTACGAAAGTTTAACTTTTGGTATATGTGCCATCCATTGGGGCATTAAAGTTTAA","protein_sequence":"MLISSRIVRSSLVNVPLRLSRCFTQAHRACKEEEVNSPLSSAAEQPEQKYTHFGSKTVLKSTKQKLVGDVFSSVANRYDLMNDVMSLGIHRLWKDHFINKLDAGKRPNSTTPLNFIDVAGGSGDIAFGLLDHAESKFGDTESTMDIVDINPDMLKEGEKRAMEQGKYFKDPRVRFLVSNGEKLEEIDSDSKDIYTVSFGIRNFTDIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIANDYDSYQYLVESIERFPDQETFKSMIEKAGFKSAGYESLTFGICAIHWGIKV"}]}