{"ymdb_id":"YMDB00157","created_at":"2011-05-29T16:02:20.000Z","updated_at":"2016-09-08T18:35:06.000Z","name":"Nicotinate D-ribonucleoside","cas":null,"state":"Solid","melting_point":null,"description":"Nicotinate D-ribonucleoside is involved in the nicotinate and nicotinamide metabolism pathways.  Nicotinate D-ribonucleoside can be reversibly converted to nicotinate and nicotinate D-ribonucleoside by purine-nucleoside phosphorylase [EC:2.4.2.1] and 5'-nucleotidase [EC:3.1.3.5], respectively.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cytoplasm","synthesis_reference":null,"chebi_id":"27748","hmdb_id":"HMDB06809","kegg_id":"C05841","pubchem_id":"161234","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium","traditional_iupac":"3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium","logp":"-5.313839270138412","pka":"11.72231566472464","alogps_solubility":"5.34e+00 g/l","alogps_logp":"-1.87","alogps_logs":"-1.74","acceptor_count":"6","donor_count":"4","rotatable_bond_count":"3","polar_surface_area":"111.10000000000002","refractivity":"59.012299999999996","polarizability":"24.20731172269263","formal_charge":"1","physiological_charge":"0","pka_strongest_basic":"-2.9841642628693164","pka_strongest_acidic":"2.757903592223079","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["D-ribosylnicotinate","Nicotinate riboside","nicotinic acid ribose","nicotinic acid riboside","ribosylnicotinate"],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21729004,"citation":"de Figueiredo, L. F., Gossmann, T. I., Ziegler, M., Schuster, S. (2011). \"Pathway Analysis of NAD+ metabolism.\" Biochem J :."}],"proteins":[{"created_at":"2011-05-26T19:26:59.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Nicotinamide riboside kinase","uniprot_id":"P53915","uniprot_name":"NRK1_YEAST","enzyme":true,"transporter":false,"gene_name":"NRK1","num_residues":240,"molecular_weight":"27689.30078","theoretical_pi":"6.68","general_function":"Involved in ATP binding","specific_function":"Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)","reactions":[{"id":1954,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2567,"direction":"\u003e","locations":null,"altext":"ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide.","export":false,"pw_reaction_id":null,"source":null},{"id":2568,"direction":"\u003e","locations":null,"altext":"ATP + D-ribosylnicotinate = ADP + nicotinate D-ribonucleotide.","export":false,"pw_reaction_id":null,"source":null},{"id":4191,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006490","source":"Smpdb"},{"id":4192,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006496","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558011","genbank_protein_id":"45269912","gene_card_id":"NRK1","chromosome_location":"chromosome 14","locus":"YNL129W","synonyms":["NRK","NmR-K","Nicotinic acid riboside kinase","Ribosylnicotinamide kinase","RNK","Ribosylnicotinic acid kinase"],"enzyme_classes":["2.7.1.22"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PRK","identifier":"PF00485"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTTCGAAAAAAGTGATATTAGTTGCATTGAGTGGATGCTCCTCCAGTGGTAAGACGACAATTGCGAAACTTACAGCAAGTTTATTCACGAAGGCTACATTAATTCATGAAGATGACTTTTACAAACATGATAATGAAGTGCCAGTAGATGCTAAATATAACATTCAAAATTGGGATTCGCCAGAAGCTCTTGATTTTAAACTTTTCGGTAAAGAATTAGATGTGATCAAACAAACTGGTAAAATAGCCACCAAACTTATACACAATAACAACGTAGATGATCCCTTTACAAAGTTCCACATTGATAGACAAGTTTGGGACGAGTTAAAGGCTAAGTATGACTCTATTAATGACGACAAATATGAAGTTGTAATTGTAGATGGGTTTATGATTTTCAATAATACTGGAATATCAAAAAAATTTGATTTGAAGATATTAGTGCGTGCTCCCTATGAAGTACTAAAAAAAAGGAGGGCTTCCAGAAAAGGATACCAGACTTTGGATTCTTTCTGGGTGGATCCGCCGTATTATTTCGACGAATTTGTGTATGAATCTTATCGTGCAAATCATGCGCAGTTATTTGTTAATGGAGACGTAGAAGGTTTACTAGACCCAAGGAAGTCAAAGAATATAAAAGAGTTCATAAATGATGATGACACTCCAATTGCGAAACCTTTAAGCTGGGTGTGCCAAGAGATTCTAAAGCTTTGTAAGGATTAG","protein_sequence":"MTSKKVILVALSGCSSSGKTTIAKLTASLFTKATLIHEDDFYKHDNEVPVDAKYNIQNWDSPEALDFKLFGKELDVIKQTGKIATKLIHNNNVDDPFTKFHIDRQVWDELKAKYDSINDDKYEVVIVDGFMIFNNTGISKKFDLKILVRAPYEVLKKRRASRKGYQTLDSFWVDPPYYFDEFVYESYRANHAQLFVNGDVEGLLDPRKSKNIKEFINDDDTPIAKPLSWVCQEILKLCKD"}]}