{"ymdb_id":"YMDB00151","created_at":"2011-05-29T16:01:50.000Z","updated_at":"2016-09-08T18:35:06.000Z","name":"4-Hydroxyphenylpyruvic acid","cas":"156-39-8","state":"Solid","melting_point":"219-220 oC","description":"4-Hydroxyphenylpyruvic acid (4-HPPA) is a keto acid. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase [EC 1.1.1.222] and is formed during tyrosine metabolism. [KEGG]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cytoplasm, Mitochondrion, Peroxisome","synthesis_reference":"Billek, Gerhard. p-Hydroxyphenylpyruvic acid. Organic Syntheses (1963), 43 49-54. ","chebi_id":"15999","hmdb_id":"HMDB00707","kegg_id":"C01179","pubchem_id":"979","cs_id":"11596439","foodb_id":null,"wikipedia_link":"4-Hydroxyphenylpyruvic_acid","biocyc_id":"P-HYDROXY-PHENYLPYRUVATE","iupac":"3-(4-hydroxyphenyl)-2-oxopropanoic acid","traditional_iupac":"4-hydroxyphenylpyruvic acid","logp":"1.596648451333333","pka":"9.498853206830276","alogps_solubility":"1.49e+00 g/l","alogps_logp":"1.12","alogps_logs":"-2.08","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"3","polar_surface_area":"74.60000000000001","refractivity":"44.6925","polarizability":"16.750960680327967","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-5.958513128269975","pka_strongest_acidic":"2.91496710599853","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["(p-hydroxyphenyl)-Pyruvate","(p-hydroxyphenyl)-Pyruvic acid","(p-Hydroxyphenyl)pyruvate","(p-Hydroxyphenyl)pyruvic acid","3-(4-hydroxyphenyl)-2-oxo-propanoate","3-(4-hydroxyphenyl)-2-oxo-propanoic acid","3-(4-Hydroxyphenyl)-2-oxopropionate","3-(4-Hydroxyphenyl)-2-oxopropionic acid","3-(4-Hydroxyphenyl)pyruvate","3-(4-Hydroxyphenyl)pyruvic acid","3-(p-Hydroxyphenyl)-2-oxopropionate","3-(p-Hydroxyphenyl)-2-oxopropionic acid","3-(p-Hydroxyphenyl)pyruvate","3-(p-Hydroxyphenyl)pyruvic acid","4-Hydroxy-a-oxobenzenepropanoate","4-Hydroxy-a-oxobenzenepropanoic acid","4-Hydroxy-alpha-oxobenzenepropanoate","4-Hydroxy-alpha-oxobenzenepropanoic acid","4-hydroxyphenylpyruvate","4HPPA","HPPA","Hydroxyphenylpyruvate","Hydroxyphenylpyruvic acid","p-hydroxyphenylpyruvic","Testacid"],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Ubiquinone and other terpenoid-quinone biosynthesis","kegg_map_id":"00130"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":1943992,"citation":"Braus, G. H. (1991). \"Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway.\" Microbiol Rev 55:349-370."}],"proteins":[{"created_at":"2011-05-27T02:39:39.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"Prephenate dehydrogenase [NADP+]","uniprot_id":"P20049","uniprot_name":"TYR1_YEAST","enzyme":true,"transporter":false,"gene_name":"TYR1","num_residues":452,"molecular_weight":"50922.89844","theoretical_pi":"6.57","general_function":"Involved in oxidoreductase activity","specific_function":"Prephenate + NADP(+) = 4-hydroxyphenylpyruvate + CO(2) + NADPH","reactions":[{"id":1910,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2683,"direction":"\u003e","locations":null,"altext":"Prephenate + NADP(+) = 4-hydroxyphenylpyruvate + CO(2) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":14102,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006522","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z36035","genbank_protein_id":"536506","gene_card_id":"TYR1","chromosome_location":"chromosome 2","locus":"YBR166C","synonyms":["PRDH"],"enzyme_classes":["1.3.1.13","1.3.1.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" prephenate dehydrogenase (NADP+) activity"},{"category":"Process","description":" aromatic amino acid family metabolic process"},{"category":"Process","description":" tyrosine metabolic process"},{"category":"Process","description":" tyrosine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"PDH","identifier":"PF02153"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"}],"gene_sequence":"ATGGTATCAGAGGATAAGATTGAGCAATGGAAAGCCACAAAAGTCATTGGTATAATTGGTCTGGGTGATATGGGCCTATTATACGCTAATAAATTTACAGATGCTGGATGGGGTGTTATATGTTGTGATAGGGAAGAATATTATGATGAACTGAAAGAAAAATATGCCTCAGCTAAATTCGAACTGGTGAAAAATGGTCATTTGGTATCCAGGCAAAGCGACTATATTATCTATAGTGTTGAAGCATCCAATATTAGTAAGATCGTCGCAACGTATGGACCATCTTCTAAGGTTGGAACAATTGTTGGGGGTCAAACGAGTTGTAAGCTGCCGGAAATCGAGGCTTTCGAAAAGTATTTACCCAAGGACTGCGACATCATTACCGTGCATTCCCTTCATGGGCCTAAAGTTAATACTGAAGGCCAACCACTAGTTATTATCAATCACAGATCACAGTACCCAGAATCTTTTGAGTTCGTTAATTCTGTTATGGCATGTTTGAAAAGTAAGCAAGTTTATTTGACATATGAAGAGCATGACAAGATTACCGCTGATACACAAGCTGTGACACATGCTGCTTTCTTAAGTATGGGATCTGCGTGGGCAAAGATAAAGATTTATCCTTGGACTCTGGGTGTAAACAAATGGTACGGTGGCCTAGAAAATGTGAAAGTTAATATATCACTAAGAATCTATTCGAACAAGTGGCATGTTTACGCAGGATTAGCCATAACAAACCCAAGTGCACATCAGCAAATTCTTCAATATGCAACCAGTGCAACAGAACTATTTAGTTTAATGATAGATAACAAAGAACAAGAACTTACTGATAGACTATTAAAAGCTAAGCAATTTGTATTTGGAAAGCATACTGGTCTCTTACTATTGGATGACACGATTTTAGAGAAATATTCGCTATCAAAAAGCAGCATTGGTAACAGCAACAATTGCAAGCCAGTGCCGAATTCACATTTATCATTGTTGGCGATTGTTGATTCGTGGTTTCAACTTGGTATTGATCCATATGATCATATGATTTGTTCGACGCCATTATTCAGAATATTCCTGGGTGTGTCCGAATATCTTTTTTTAAAACCTGGCTTATTAGAACAGACAATTGATGCAGCTATCCATGATAAATCATTCATAAAAGATGATTTAGAATTTGTTATTTCGGCTAGAGAATGGAGCTCGGTTGTTTCTTTTGCCAATTTTGATATATACAAAAAGCAATTTCAGAGTGTTCAAAAGTTCTTTGAGCCAATGCTTCCAGAGGCTAATCTCATTGGCAACGAGATGATAAAAACCATTCTGAGTCATTCTAGTGACCGTTCGGCCGCTGAAAAAAGAAATACATAA","protein_sequence":"MVSEDKIEQWKATKVIGIIGLGDMGLLYANKFTDAGWGVICCDREEYYDELKEKYASAKFELVKNGHLVSRQSDYIIYSVEASNISKIVATYGPSSKVGTIVGGQTSCKLPEIEAFEKYLPKDCDIITVHSLHGPKVNTEGQPLVIINHRSQYPESFEFVNSVMACLKSKQVYLTYEEHDKITADTQAVTHAAFLSMGSAWAKIKIYPWTLGVNKWYGGLENVKVNISLRIYSNKWHVYAGLAITNPSAHQQILQYATSATELFSLMIDNKEQELTDRLLKAKQFVFGKHTGLLLLDDTILEKYSLSKSSIGNSNNCKPVPNSHLSLLAIVDSWFQLGIDPYDHMICSTPLFRIFLGVSEYLFLKPGLLEQTIDAAIHDKSFIKDDLEFVISAREWSSVVSFANFDIYKKQFQSVQKFFEPMLPEANLIGNEMIKTILSHSSDRSAAEKRNT"}]}