{"ymdb_id":"YMDB00148","created_at":"2011-05-29T16:01:37.000Z","updated_at":"2016-09-08T18:35:06.000Z","name":"Chorismate","cas":"55508-12-8","state":"Solid","melting_point":"140 oC ","description":"Chorismate is an important intermediate that leads to the biosynthesis of several essential metabolites, including the aromatic amino acids L-phenylalanine, L-tyrosine and L-tryptophan, vitamins E and K, ubiquinone and certain siderophore. [Biocyc ARO-PWY]","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"Cytoplasm;Nucleus","synthesis_reference":null,"chebi_id":"17333","hmdb_id":"HMDB12199","kegg_id":"C00251","pubchem_id":"12039","cs_id":"11542","foodb_id":null,"wikipedia_link":"Chorismic_acid","biocyc_id":"CPD-9517","iupac":"(3R,4R)-3-[(1-carboxyeth-1-en-1-yl)oxy]-4-hydroxycyclohexa-1,5-diene-1-carboxylic acid","traditional_iupac":"chorismic acid","logp":"-0.12549059733333331","pka":"4.206666263255496","alogps_solubility":"8.80e+00 g/l","alogps_logp":"0.52","alogps_logs":"-1.41","acceptor_count":"6","donor_count":"3","rotatable_bond_count":"4","polar_surface_area":"104.06","refractivity":"54.310100000000006","polarizability":"20.487779256263384","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.356475185932375","pka_strongest_acidic":"3.3942809060486976","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["Chorismic acid"],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Ubiquinone and other terpenoid-quinone biosynthesis","kegg_map_id":"00130"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":348687,"citation":"Miozzari, G., Niederberger, P., Hutter, R. (1978). \"Tryptophan biosynthesis in Saccharomyces cerevisiae: control of the flux through the pathway.\" J Bacteriol 134:48-59."},{"pubmed_id":1943992,"citation":"Braus, G. H. (1991). \"Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway.\" Microbiol Rev 55:349-370."},{"pubmed_id":8971708,"citation":"Henstrand, J. M., Schaller, A., Braun, M., Amrhein, N., Schmid, J. (1996). \"Saccharomyces cerevisiae chorismate synthase has a flavin reductase activity.\" Mol Microbiol 22:859-866."},{"pubmed_id":8001582,"citation":"Crombie, T., Boyle, J. P., Coggins, J. R., Brown, A. J. (1994). \"The folding of the bifunctional TRP3 protein in yeast is influenced by a translational pause which lies in a region of structural divergence with Escherichia coli indoleglycerol-phosphate synthase.\" Eur J Biochem 226:657-664."},{"pubmed_id":3027508,"citation":"Ball, S. G., Wickner, R. B., Cottarel, G., Schaus, M., Tirtiaux, C. (1986). \"Molecular cloning and characterization of ARO7-OSM2, a single yeast gene necessary for chorismate mutase activity and growth in hypertonic medium.\" Mol Gen Genet 205:326-330."}],"proteins":[{"created_at":"2011-05-24T19:23:19.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"Anthranilate synthase component 2","uniprot_id":"P00937","uniprot_name":"TRPG_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP3","num_residues":484,"molecular_weight":"53488.89844","theoretical_pi":"6.91","general_function":"Involved in catalytic activity","specific_function":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate","reactions":[{"id":1657,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2251,"direction":"\u003e","locations":"","altext":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2252,"direction":"\u003e","locations":null,"altext":"1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":14103,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006527","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"K01386","genbank_protein_id":"173045","gene_card_id":"TRP3","chromosome_location":"chromosome 11","locus":"YKL211C","synonyms":["Anthranilate synthase component II","Glutamine amidotransferase","Indole-3-glycerol phosphate synthase","PRAI"],"enzyme_classes":["4.1.3.27","4.1.1.48"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" indole-3-glycerol-phosphate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" anthranilate synthase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"IGPS","identifier":"PF00218"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGTCTGTGCACGCTGCAACAAACCCAATCAATAAGCATGTGGTTCTAATTGACAACTACGATTCCTTTACCTGGAACGTTTACGAGTACTTGTGCCAGGAGGGCGCCAAAGTGAGCGTCTACCGTAACGATGCAATTACAGTTCCAGAAATTGCCGCCTTGAATCCCGACACATTGCTTATCTCGCCTGGACCAGGCCACCCAAAGACAGATTCTGGCATTTCAAGAGACTGTATCCGGTACTTTACTGGGAAAATTCCTGTATTTGGAATCTGTATGGGCCAGCAATGCATGTTTGACGTATTTGGTGGTGAAGTTGCCTACGCTGGTGAGATTGTCCACGGTAAAACGTCCCCAATCTCTCACGACAACTGTGGAATTTTCAGGAACGTGCCGCAAGGTATTGCTGTGACAAGATACCATTCATTGGCCGGGACAGAATCGTCCCTACCATCCTGCTTGAAGGTTACTGCGAGTACCGAAAATGGAATTATCATGGGTGTAAGACACAAGAAGTACACTGTAGAAGGTGTGCAATTTCATCCGGAATCCATCTTGACCGAGGAAGGTCATCTGATGATCAGGAACATTTTAAACGTCAGTGGAGGCACTTGGGAGGAAAACAAATCATCTCCTTCAAATTCTATTTTGGACCGTATCTATGCTCGGCGTAAAATAGACGTCAATGAGCAGTCTAAAATCCCAGGTTTCACCTTTCAAGACTTACAATCTAACTATGATTTAGGTCTTGCCCCACCGTTACAGGATTTCTACACGGTGTTGTCATCATCCCATAAAAGAGCCGTTGTTCTTGCTGAAGTCAAGCGTGCCTCTCCATCGAAGGGACCCATTTGTTTAAAAGCTGTTGCTGCTGAACAGGCTCTCAAATACGCAGAGGCTGGTGCATCCGCAATTTCCGTATTGACCGAACCTCATTGGTTTCACGGTTCGTTACAGGATTTAGTAAATGTGAGGAAAATCCTAGATTTGAAATTTCCTCCCAAGGAGAGGCCTTGTGTTTTGAGAAAAGAATTTATTTTCAGCAAGTATCAAATACTAGAAGCAAGATTAGCTGGAGCTGACACTGTCCTTCTTATAGTCAAGATGCTATCTCAACCCTTATTGAAGGAACTGTACAGCTACAGTAAAGATTTGAACATGGAACCTCTCGTTGAGGTGAACTCCAAAGAGGAATTACAAAGGGCTCTAGAAATTGGTGCTAAAGTTGTAGGTGTCAATAATAGGGACCTGCATTCATTCAACGTAGACCTAAATACCACCAGTAACTTGGTAGAATCTATTCCAAAGGATGTTCTTCTAATTGCTCTATCGGGAATTACCACCAGGGACGATGCTGAAAAATACAAAAAAGAAGGTGTCCATGGATTTTTAGTGGGTGAAGCCCTAATGAAATCAACCGATGTGAAGAAGTTCATTCATGAATTATGCGAATAA","protein_sequence":"MSVHAATNPINKHVVLIDNYDSFTWNVYEYLCQEGAKVSVYRNDAITVPEIAALNPDTLLISPGPGHPKTDSGISRDCIRYFTGKIPVFGICMGQQCMFDVFGGEVAYAGEIVHGKTSPISHDNCGIFKNVPQGIAVTRYHSLAGTESSLPSCLKVTASTENGIIMGVRHKKYTVEGVQFHPESILTEEGHLMIRNILNVSGGTWEENKSSPSNSILDRIYARRKIDVNEQSKIPGFTFQDLQSNYDLGLAPPLQDFYTVLSSSHKRAVVLAEVKRASPSKGPICLKAVAAEQALKYAEAGASAISVLTEPHWFHGSLQDLVNVRKILDLKFPPKERPCVLRKEFIFSKYQILEARLAGADTVLLIVKMLSQPLLKELYSYSKDLNMEPLVEVNSKEELQRALEIGAKVVGVNNRDLHSFNVDLNTTSNLVESIPKDVLLIALSGITTRDDAEKYKKEGVHGFLVGEALMKSTDVKKFIHELCE"},{"created_at":"2011-05-24T19:34:32.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Anthranilate synthase component 1","uniprot_id":"P00899","uniprot_name":"TRPE_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP2","num_residues":507,"molecular_weight":"56767.0","theoretical_pi":"5.65","general_function":"Involved in biosynthetic process","specific_function":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate","reactions":[{"id":2251,"direction":"\u003e","locations":"","altext":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":14103,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006527","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U18839","genbank_protein_id":"603328","gene_card_id":"TRP2","chromosome_location":"chromosome 5","locus":"YER090W","synonyms":["Anthranilate synthase component I"],"enzyme_classes":["4.1.3.27"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" anthranilate synthase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" tryptophan biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"}],"pfams":[{"name":"Anth_synt_I_N","identifier":"PF04715"},{"name":"Chorismate_bind","identifier":"PF00425"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACCGCTTCCATCAAAATTCAACCGGATATTGACTCTCTAAAGCAATTACAGCAGCAAAATGACGATAGTTCCATAAATATGTATCCCGTGTATGCGTATTTGCCATCATTGGATCTGACTCCTCACGTGGCATATCTAAAATTGGCACAATTGAACAACCCTGATAGAAAGGAATCATTTCTGTTGGAAAGTGCTAAGACAAATAATGAATTAGATCGTTATTCATTCATAGGTATCTCGCCACGCAAGACCATCAAAACCGGTCCTACTGAAGGCATTGAAACAGATCCTTTGGAAATTTTGGAAAAGGAGATGTCTACCTTTAAAGTAGCCGAAAATGTTCCTGGTTTACCGAAATTAAGTGGTGGTGCTATTGGTTATATTTCTTATGACTGTGTTCGTTATTTCGAGCCAAAAACAAGAAGGCCTTTGAAAGATGTCCTAAGACTTCCAGAGGCATATTTAATGCTTTGTGATACCATTATTGCCTTTGATAATGTTTTTCAGAGATTTCAAATCATTCATAACATTAATACCAATGAAACTTCGTTGGAGGAAGGTTACCAAGCTGCAGCACAAATAATCACTGATATCGTATCAAAGCTAACCGACGATTCCTCGCCAATACCATATCCAGAACAACCTCCTATTAAATTGAATCAAACTTTTGAATCGAATGTGGGCAAGGAAGGTTACGAAAATCACGTCTCCACTTTGAAGAAGCATATTAAGAAAGGTGATATTATTCAAGGTGTGCCATCGCAAAGAGTGGCAAGGCCAACTTCGTTACATCCTTTCAATATTTACAGACATTTACGTACAGTGAACCCATCTCCTTACCTGTTTTATATTGATTGTTTGGATTTCCAAATCATTGGTGCATCTCCAGAATTGTTGTGCAAATCGGATTCCAAAAATAGAGTCATTACCCATCCAATTGCTGGTACTGTCAAACGTGGGGCTACTACTGAAGAGGATGATGCTTTAGCGGACCAATTACGTGGCTCGTTAAAAGACCGTGCAGAACATGTTATGCTGGTAGATTTAGCAAGAAACGATATTAACAGAATTTGTGACCCATTAACAACAAGTGTCGATAAACTGTTAACTATTCAAAAATTTTCTCATGTCCAACATCTGGTTTCTCAAGTCAGCGGTGTTCTCCGCCCAGAAAAGACAAGATTTGATGCATTCAGATCGATTTTCCCTGCAGGTACTGTCAGTGGTGCTCCAAAGGTTAGAGCCATGGAATTGATTGCCGAACTAGAAGGAGAAAGGCGTGGGGTTTATGCAGGCGCCGTAGGTCATTGGTCATACGACGGTAAAACAATGGACAATTGTATCGCTTTAAGGACTATGGTCTATAAAGATGGCATTGCTTACTTGCAAGCTGGCGGTGGTATTGTTTACGATTCAGATGAGTACGATGAATATGTCGAAACCATGAATAAAATGATGGCCAATCACAGTACTATTGTGCAAGCAGAAGAATTGTGGGCCGATATCGTAGGATCAGCTTAA","protein_sequence":"MTASIKIQPDIDSLKQLQQQNDDSSINMYPVYAYLPSLDLTPHVAYLKLAQLNNPDRKESFLLESAKTNNELDRYSFIGISPRKTIKTGPTEGIETDPLEILEKEMSTFKVAENVPGLPKLSGGAIGYISYDCVRYFEPKTRRPLKDVLRLPEAYLMLCDTIIAFDNVFQRFQIIHNINTNETSLEEGYQAAAQIITDIVSKLTDDSSPIPYPEQPPIKLNQTFESNVGKEGYENHVSTLKKHIKKGDIIQGVPSQRVARPTSLHPFNIYRHLRTVNPSPYLFYIDCLDFQIIGASPELLCKSDSKNRVITHPIAGTVKRGATTEEDDALADQLRGSLKDRAEHVMLVDLARNDINRICDPLTTSVDKLLTIQKFSHVQHLVSQVSGVLRPEKTRFDAFRSIFPAGTVSGAPKVRAMELIAELEGERRGVYAGAVGHWSYDGKTMDNCIALRTMVYKDGIAYLQAGGGIVYDSDEYDEYVETMNKMMANHSTIVQAEELWADIVGSA"},{"created_at":"2011-05-24T19:41:28.000Z","updated_at":"2011-07-22T17:53:48.000Z","name":"Aminodeoxychorismate synthase","uniprot_id":"P37254","uniprot_name":"PABS_YEAST","enzyme":true,"transporter":false,"gene_name":"ABZ1","num_residues":787,"molecular_weight":"88543.5","theoretical_pi":"5.55","general_function":"Involved in biosynthetic process","specific_function":"Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis","reactions":[{"id":1189,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2264,"direction":"\u003e","locations":"Cytoplasm","altext":"Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":4145,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006446","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY693029","genbank_protein_id":"51013509","gene_card_id":"ABZ1","chromosome_location":"chromosome 14","locus":"YNR033W","synonyms":["ADC synthase","P-aminobenzoic acid synthase","PABA synthase","Para-aminobenzoate synthase"],"enzyme_classes":["2.6.1.85"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" anthranilate synthase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"Anth_synt_I_N","identifier":"PF04715"},{"name":"Chorismate_bind","identifier":"PF00425"}],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGCTGTCCGATACAATTGACACAAAGCAACAACAGCAACAGCTTCATGTCCTGTTCATAGACTCTTATGATTCATTCACCTACAATGTAGTGAGACTAATTGAACAACAAACTGATATCTCACCGGGAGTCAACGCCGTGCACGTGACGACGGTACATAGTGATACGTTCCAATCTATGGATCAGCTATTGCCACTTTTGCCGCTTTTTGATGCTATCGTTGTTGGCCCAGGACCTGGGAATCCCAACAATGATGCACAAGATATGGGTATAATATCTGAGCTTTTCGAGAATGCCAATGGAAAGTTAGATGAAGTTCCAATATTGGGTATATGTCTTGGGTTCCAAGCAATGTGCTTGGCTCAAGGTGCTGATGTCAGTGAGCTAAATACTATCAAGCATGGGCAAGTGTATGAAATGCATTTAAACGATGCAGCCAGAGCTTGTGGCCTTTTTTCTGGTTATCCCGATACGTTCAAATCTACGAGGTACCATTCATTGCATGTCAATGCCGAAGGCATTGACACCCTTTTGCCCTTATGCACAACCGAAGATGAGAACGGTATTCTTTTGATGAGTGCTCAAACGAAAAATAAGCCATGGTTTGGCGTACAGTACCACCCGGAGTCATGTTGTTCAGAATTGGGGGGGCTGTTAGTCAGTAACTTTCTCAAGTTGAGTTTCATAAATAACGTGAAGACAGGAAGGTGGGAAAAGAAGAAACTTAATGGAGAGTTTTCCGATATCCTATCTCGATTGGATAGGACTATTGATAGAGACCCCATATACAAGGTAAAAGAGAAATATCCGAAGGGCGAGGACACAACTTACGTTAAGCAGTTCGAGGTCTCTGAAGACCCGAAATTGACATTTGAAATTTGCAACATCATACGAGAAGAAAAATTTGTCATGTCATCTTCTGTGATTAGTGAAAATACGGGTGAATGGTCTATCATTGCTTTACCAAACTCCGCATCCCAGGTATTCACTCATTATGGAGCTATGAAAAAGACTACAGTTCATTATTGGCAAGATAGTGAAATTAGTTACACCTTGTTGAAAAAGTGTCTAGATGGTCAAGATTCGGATTTGCCTGGCTCCCTTGAGGTAATACATGAAGATAAATCCCAATTTTGGATCACTTTGGGTAAATTTATGGAGAATAAAATAATCGATAACCACAGAGAAATACCTTTTATTGGAGGTCTTGTTGGCATTTTAGGTTATGAAATAGGTCAGTACATTGCATGCGGCCGTTGCAATGATGATGAGAATTCCCTTGTTCCCGACGCCAAACTAGTTTTTATCAACAATAGTATAGTCATTAATCACAAGCAAGGGAAGCTTTATTGTATTTCTCTGGATAATACATTTCCAGTGGCATTAGAACAATCATTAAGGGACAGTTTTGTTAGAAAGAAGAATATTAAGCAATCCCTGTCCTGGCCCAAGTATCTTCCAGAGGAGATAGACTTCATTATAACTATGCCCGATAAACTTGACTACGCTAAGGCGTTTAAGAAATGTCAGGATTATATGCATAAGGGTGATTCTTATGAAATGTGTCTCACAACGCAAACCAAAGTTGTACCATCTGCGGTGATAGAACCCTGGAGGATTTTCCAGACCTTGGTACAAAGAAACCCGGCTCCATTTTCAAGTTTTTTTGAGTTTAAAGACATTATTCCCCGCCAAGATGAAACGCCTCCAGTTTTGTGCTTCTTAAGTACTTCTCCAGAAAGGTTTTTGAAGTGGGATGCAGACACATGCGAGCTACGTCCCATCAAGGGAACTGTGAAAAAAGGACCGCAAATGAACTTGGCAAAAGCCACACGAATCCTGAAGACACCAAAAGAATTTGGTGAGAACTTAATGATTTTGGACTTAATCAGAAATGACCTTTACGAGTTGGTTCCTGACGTTCGGGTGGAGGAGTTCATGTCCGTGCAAGAATATGCCACCGTTTACCAACTCGTTAGCGTCGTAAAGGCACATGGATTGACCTCTGCCAGTAAGAAGACGAGATATTCAGGCATTGATGTCCTTAAACACTCGCTTCCTCCGGGATCTATGACGGGAGCCCCCAAGAAGATTACTGTGCAATTATTGCAGGACAAGATAGAAAGCAAGCTAAACAAACATGTCAATGGTGGAGCACGTGGTGTTTACAGCGGTGTCACGGGATATTGGTCTGTGAATTCCAACGGAGATTGGTCTGTTAACATTAGATGTATGTATTCCTACAACGGCGGAACCAGCTGGCAACTCGGTGCAGGGGGGGCCATAACAGTCTTAAGCACACTAGATGGCGAACTAGAGGAAATGTACAACAAGTTGGAGAGCAACTTACAAATTTTCATGTAG","protein_sequence":"MLSDTIDTKQQQQQLHVLFIDSYDSFTYNVVRLIEQQTDISPGVNAVHVTTVHSDTFQSMDQLLPLLPLFDAIVVGPGPGNPNNGAQDMGIISELFENANGKLDEVPILGICLGFQAMCLAQGADVSELNTIKHGQVYEMHLNDAARACGLFSGYPDTFKSTRYHSLHVNAEGIDTLLPLCTTEDENGILLMSAQTKNKPWFGVQYHPESCCSELGGLLVSNFLKLSFINNVKTGRWEKKKLNGEFSDILSRLDRTIDRDPIYKVKEKYPKGEDTTYVKQFEVSEDPKLTFEICNIIREEKFVMSSSVISENTGEWSIIALPNSASQVFTHYGAMKKTTVHYWQDSEISYTLLKKCLDGQDSDLPGSLEVIHEDKSQFWITLGKFMENKIIDNHREIPFIGGLVGILGYEIGQYIACGRCNDDENSLVPDAKLVFINNSIVINHKQGKLYCISLDNTFPVALEQSLRDSFVRKKNIKQSLSWPKYLPEEIDFIITMPDKLDYAKAFKKCQDYMHKGDSYEMCLTTQTKVVPSAVIEPWRIFQTLVQRNPAPFSSFFEFKDIIPRQDETPPVLCFLSTSPERFLKWDADTCELRPIKGTVKKGPQMNLAKATRILKTPKEFGENLMILDLIRNDLYELVPDVRVEEFMSVQEYATVYQLVSVVKAHGLTSASKKTRYSGIDVLKHSLPPGSMTGAPKKITVQLLQDKIESKLNKHVNGGARGVYSGVTGYWSVNSNGDWSVNIRCMYSYNGGTSWQLGAGGAITVLSTLDGELEEMYNKLESNLQIFM"},{"created_at":"2011-05-27T02:43:32.000Z","updated_at":"2011-07-22T17:54:27.000Z","name":"Chorismate synthase","uniprot_id":"P28777","uniprot_name":"AROC_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO2","num_residues":376,"molecular_weight":"40838.0","theoretical_pi":"7.92","general_function":"Involved in chorismate synthase activity","specific_function":"5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate","reactions":[{"id":1390,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2690,"direction":"\u003e","locations":null,"altext":"5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1R53","cellular_location":null,"genbank_gene_id":"X60190","genbank_protein_id":"3387","gene_card_id":"ARO2","chromosome_location":"chromosome 7","locus":"YGL148W","synonyms":["5-enolpyruvylshikimate-3-phosphate phospholyase"],"enzyme_classes":["4.2.3.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" carbon-oxygen lyase activity, acting on phosphates"},{"category":"Function","description":" chorismate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Process","description":" aromatic amino acid family biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"}],"pfams":[{"name":"Chorismate_synt","identifier":"PF01264"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"}],"gene_sequence":"ATGTCAACGTTTGGGAAACTGTTCCGCGTCACCACATATGGTGAATCGCATTGTAAGTCTGTCGGTTGCATTGTCGACGGTGTTCCTCCAGGAATGTCATTAACCGAAGCTGACATTCAGCCACAATTGACCAGAAGAAGACCGGGTCAATCTAAGCTATCGACCCCTAGAGACGAAAAGGATAGAGTGGAAATCCAGTCCGGTACCGAGTTCGGCAAGACTCTAGGTACACCCATCGCCATGATGATCAAAAACGAGGACCAAAGACCTCACGACTACTCCGACATGGACAAGTTCCCTAGACCTTCCCATGCGGACTTCACGTACTCGGAAAAGTACGGTATCAAGGCCTCCTCTGGTGGTGGCAGAGCTTCTGCTAGAGAAACGATTGGCCGTGTCGCTTCAGGTGCCATTGCTGAGAAGTTCTTAGCTCAGAACTCTAATGTCGAGATCGTAGCCTTTGTGACACAAATCGGGGAAATCAAGATGAACAGAGACTCTTTCGATCCTGAATTTCAGCATCTGTTGAACACCATCACCAGGGAAAAAGTGGACTCAATGGGTCCTATCAGATGTCCAGACGCCTCCGTTGCTGGTTTGATGGTCAAGGAAATCGAAAAGTACAGAGGCAACAAGGACTCTATCGGTGGTGTCGTCACTTGTGTCGTGAGAAACTTGCCTACCGGTCTCGGTGAGCCATGCTTTGACAAGTTGGAAGCCATGTTGGCTCATGCTATGTTGTCCATTCCAGCATCCAAGGGTTTCGAAATTGGCTCAGGTTTTCAGGGTGTCTCTGTTCCAGGGTCCAAGCACAATGACCCATTTTACTTTGAAAAAGAAACAAACAGATTAAGAACAAAGACCAACAATTCAGGTGGTGTACAAGGTGGTATCTCTAATGGTGAGAACATCTATTTCTCTGTCCCATTCAAGTCAGTGGCCACTATCTCTCAAGAACAAAAAACCGCCACTTACGATGGTGAAGAAGGTATCTTAGCCGCTAAGGGTAGACATGACCCTGCTGTCACTCCAAGAGCTATTCCTATTGTGGAAGCCATGACCGCTCTGGTGTTGGCTGACGCGCTTTTGATCCAAAAGGCAAGAGATTTCTCCAGATCCGTGGTTCATTAA","protein_sequence":"MSTFGKLFRVTTYGESHCKSVGCIVDGVPPGMSLTEADIQPQLTRRRPGQSKLSTPRDEKDRVEIQSGTEFGKTLGTPIAMMIKNEDQRPHDYSDMDKFPRPSHADFTYSEKYGIKASSGGGRASARETIGRVASGAIAEKFLAQNSNVEIVAFVTQIGEIKMNRDSFDPEFQHLLNTITREKVDSMGPIRCPDASVAGLMVKEIEKYRGNKDSIGGVVTCVVRNLPTGLGEPCFDKLEAMLAHAMLSIPASKGFEIGSGFQGVSVPGSKHNDPFYFEKETNRLRTKTNNSGGVQGGISNGENIYFSVPFKSVATISQEQKTATYDGEEGILAAKGRHDPAVTPRAIPIVEAMTALVLADALLIQKARDFSRSVVH"},{"created_at":"2011-05-27T02:44:03.000Z","updated_at":"2011-07-22T17:54:27.000Z","name":"Chorismate mutase","uniprot_id":"P32178","uniprot_name":"CHMU_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO7","num_residues":256,"molecular_weight":"29746.80078","theoretical_pi":"6.17","general_function":"Involved in chorismate mutase activity","specific_function":"Chorismate = prephenate","reactions":[{"id":1388,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2691,"direction":"\u003e","locations":null,"altext":"Chorismate = prephenate.","export":false,"pw_reaction_id":null,"source":null},{"id":14091,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006516","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"4CSM","cellular_location":null,"genbank_gene_id":"AY693179","genbank_protein_id":"51013809","gene_card_id":"ARO7","chromosome_location":"chromosome 16","locus":"YPR060C","synonyms":["CM"],"enzyme_classes":["5.4.99.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Function","description":" chorismate mutase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" aromatic amino acid family biosynthetic process"},{"category":"Process","description":" dicarboxylic acid metabolic process"},{"category":"Process","description":" chorismate metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"}],"pfams":[{"name":"CM_2","identifier":"PF01817"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"}],"gene_sequence":"ATGGATTTCACAAAACCAGAAACTGTTTTAAATCTACAAAATATTAGAGATGAATTAGTTAGAATGGAGGATTCGATCATCTTCAAATTTATTGAGAGGTCGCATTTCGCCACATGTCCTTCAGTTTATGAGGCAAACCATCCAGGTTTAGAAATTCCGAATTTTAAAGGATCTTTCTTGGATTGGGCTCTTTCAAATCTTGAAATTGCGCATTCTCGCATCAGAAGATTCGAATCACCTGATGAAACTCCCTTCTTTCCTGACAAGATTCAGAAATCATTCTTACCGAGCATTAACTACCCACAAATTTTGGCGCCTTATGCCCCAGAAGTTAATTACAATGATAAAATAAAAAAAGTTTATATTGAAAAGATTATACCATTAATTTCGAAAAGAGATGGTGATGATAAGAATAACTTCGGTTCTGTTGCCACTAGAGATATAGAATGTTTGCAAAGCTTGAGTAGGAGAATCCACTTTGGCAAGTTTGTTGCTGAAGCCAAGTTCCAATCGGATATCCCGCTATACACAAAGCTGATCAAAAGTAAAGATGTCGAGGGGATAATGAAGAATATCACCAATTCTGCCGTTGAAGAAAAGATTCTAGAAAGATTAACTAAGAAGGCTGAAGTCTATGGTGTGGACCCTACCAACGAGTCAGGTGAAAGAAGGATTACTCCAGAATATTTGGTAAAAATTTATAAGGAAATTGTTATACCTATCACTAAGGAAGTTGAGGTGGAATACTTGCTAAGAAGGTTGGAAGAGTAA","protein_sequence":"MDFTKPETVLNLQNIRDELVRMEDSIIFKFIERSHFATCPSVYEANHPGLEIPNFKGSFLDWALSNLEIAHSRIRRFESPDETPFFPDKIQKSFLPSINYPQILAPYAPEVNYNDKIKKVYIEKIIPLISKRDGDDKNNFGSVATRDIECLQSLSRRIHFGKFVAEAKFQSDIPLYTKLIKSKDVEGIMKNITNSAVEEKILERLTKKAEVYGVDPTNESGERRITPEYLVKIYKEIVIPITKEVEVEYLLRRLEE"}]}