{"ymdb_id":"YMDB00137","created_at":"2011-05-29T16:00:26.000Z","updated_at":"2016-09-08T18:35:05.000Z","name":"Trehalose 6-phosphate","cas":"4484-88-2","state":"Solid","melting_point":"","description":"Trehalose 6-phosphate is a substrate for hexokinase (type I) and tryptase beta-1. It is an intermediate in trehalose synthesis pathway. Trehalose is a disaccharide that is ubiquitous in the biosphere. It consists of two subunits of glucose bound by an alpha:1-1 linkage (alpha-D-glucopyranosil alpha-D-glucopyranoside) and is thus nonreducing. Trehalose has been isolated and characterized from many prokaryotic and eukaryotic organisms, including bacteria, yeast, plants, insects and mammals. [Biocyc TRESYN-PWY]","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":"MacDonald, Donald L.; Wong, Roger Y. K.  Chemical synthesis of trehalose 6-phosphate.    Biochimica et Biophysica Acta, General Subjects  (1964),  86(2),  390-2.","chebi_id":"18283","hmdb_id":"HMDB01124","kegg_id":"C00689","pubchem_id":"122336","cs_id":"24785573","foodb_id":null,"wikipedia_link":null,"biocyc_id":"TREHALOSE-6P","iupac":"{[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]methoxy}phosphonic acid","traditional_iupac":"α,α'-trehalose 6-phosphate","logp":"-4.826940895000001","pka":"6.248730303005783","alogps_solubility":"4.06e+01 g/l","alogps_logp":"-2.42","alogps_logs":"-1.02","acceptor_count":"13","donor_count":"9","rotatable_bond_count":"6","polar_surface_area":"236.05999999999997","refractivity":"79.20959999999998","polarizability":"35.55248902220106","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.6483797433063936","pka_strongest_acidic":"1.2229090506224631","bioavailability":"0","number_of_rings":"2","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["alpha-D-glucopyranosyl alpha-D-glucopyranoside 6-(dihydrogen phosphate)","alpha,alpha'-Trehalose 6-phosphate","Trehalose 6-phosphate","Trehalose 6-phosphic acid","Trehalose-6-phosphate"],"pathways":[{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":8354408,"citation":"Blazquez, M. A., Lagunas, R., Gancedo, C., Gancedo, J. M. (1993). \"Trehalose-6-phosphate, a new regulator of yeast glycolysis that inhibits hexokinases.\" FEBS Lett 329:51-54."},{"pubmed_id":8444170,"citation":"De Virgilio, C., Burckert, N., Bell, W., Jeno, P., Boller, T., Wiemken, A. (1993). \"Disruption of TPS2, the gene encoding the 100-kDa subunit of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae, causes accumulation of trehalose-6-phosphate and loss of trehalose-6-phosphate phosphatase activity.\" Eur J Biochem 212:315-323."}],"proteins":[{"created_at":"2011-05-24T19:53:53.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Trehalose-phosphatase","uniprot_id":"P31688","uniprot_name":"TPS2_YEAST","enzyme":true,"transporter":false,"gene_name":"TPS2","num_residues":896,"molecular_weight":"102976.0","theoretical_pi":"8.29","general_function":"Involved in catalytic activity","specific_function":"Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process","reactions":[{"id":2019,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2279,"direction":"\u003e","locations":"Cytoplasm","altext":"Trehalose 6-phosphate + H(2)O = trehalose + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14365,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006883","source":"Smpdb"},{"id":14366,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006884","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X70694","genbank_protein_id":"406769","gene_card_id":"TPS2","chromosome_location":"chromosome 4","locus":"YDR074W","synonyms":["Trehalose synthase complex catalytic subunit TPS2","Trehalose-6-phosphate phosphatase","TPP"],"enzyme_classes":["3.1.3.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" oligosaccharide metabolic process"},{"category":"Process","description":" disaccharide metabolic process"},{"category":"Process","description":" trehalose metabolic process"},{"category":"Process","description":" trehalose biosynthetic process"}],"pfams":[{"name":"Glyco_transf_20","identifier":"PF00982"},{"name":"Trehalose_PPase","identifier":"PF02358"}],"pathways":[{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"}],"gene_sequence":"ATGACCACCACTGCCCAAGACAATTCTCCAAAGAAGAGACAGCGTATCATCAATTGTGTCACGCAGCTGCCCTACAAAATCCAATTGGGAGAAAGCAACGATGACTGGAAAATATCTGCTACTACAGGTAACAGCGCATTATATTCCTCTCTAGAATACCTTCAATTTGATTCTACCGAGTACGAGCAACACGTTGTTGGTTGGACCGGCGAAATAACAAGAACCGAACGCAACCTGTTTACTAGAGAAGCGAAAGAGAAACCACAGGATCTGGACGATGACCCACTATATTTAACAAAAGAGCAGATCAATGGGTTGACTACTACTCTACAAGATCATATGAAATCTGATAAAGAGGCAAAGACCGATACTACTCAAACAGCTCCCGTTACCAATAACGTTCATCCCGTTTGGCTACTTAGAAAAAACCAGAGTAGATGGAGAAATTACGCGGAAAAAGTAATTTGGCCAACCTTCCACTACATCTTGAATCCTTCAAATGAAGGTGAGCAAGAAAAAAACTGGTGGTACGACTACGTCAAGTTTAACGAAGCTTATGCACAAAAAATCGGGGAAGTTTACAGGAAGGGTGACATCATCTGGATCCATGACTACTACCTACTGCTATTGCCTCAACTACTGAGAATGAAATTTAACGACGAATCTATCATTATTGGTTATTTCCATCATGCCCCATGGCCTAGTAATGAATATTTTCGCTGTTTGCCACGTAGAAAACAAATCTTAGATGGTCTTGTTGGGGCCAATAGAATTTGTTTCCAAAATGAATCTTTCTCCCGTCATTTTGTATCGAGTTGTAAAAGATTACTCGACGCAACCGCCAAGAAATCTAAAAACTCTTCCGATAGTGATCAATATCAAGTGTCTGTGTACGGTGGTGACGTACTCGTAGATTCTTTGCCTATAGGTGTTAACACAACTCAAATACTGAAAGATGCTTTCACGAAGGATATAGATTCCAAGGTTCTTTCCATCAAGCAAGCTTATCAAAACAAAAAAATTATTATTGGTAGAGATCGTCTGGATTCCGTCAGAGGCGTCGTTCAAAAATTAAGAGCTTTTGAAACTTTCTTGGCCATGTATCCAGAATGGCGAGATCAAGTGGTATTGATCCAGGTCAGCAGTCCTACTGCTAACAGAAATTCCCCCCAAACTATCAGATTGGAACAACAAGTCAACGAGTTGGTTAATTCCATAAATTCTGAATATGGTAATTTGAATTTTTCTCCCGTCCAGCATTATTATATGAGAATCCCTAAAGATGTATACTTGTCCTTACTAAGAGTTGCAGACTTATGTTTAATCACAAGTGTTAGAGACGGTATGAATACCACTGCTTTGGAATACGTCACTGTGAAATCTCACATGTCGAACTTTTTATGCTACGGAAATCCATTGATTTTAAGTGAGTTTTCTGGCTCTAGTAACGTATTGAAAGATGCCATTGTCGTTAACCCATGGGATTCGGTGGCCGTGGCTAAATCTATTAACATGGCTTTGAAATTGGACAAGGAAGAAAAGTCCAATTTAGAATCAAAATTATGGAAAGAAGTTCCTACAATTCAAGATTGGACTAATAAGTTTTTGAGTTCATTAAAGGAAAAGGCGTCATCTGATGATGATGTGGAAAGGAAAATGACTCCAGCACTTAATAGACCTGTTCTTTTAGAAAACTACAAGCAGGCTAAGCGTAGATTATTCCTTTTTGATTACGATGGTACTTTGACCCCAATTGTCAAAGACCCAGCTGCAGCTATTCCATCGGCAAGACTTTATACAATTCTACAAAAATTATGTGCCGATCCTCATAATCAAATCTGGATTATTTCTGGTCGTGACCAGAAGTTTTTGAACAAGTGGTTAGGCGGTAAACTTCCTCAACTGGGTCTAAGTGCGGAGCATGGATGTTTCATGAAAGATGTTTCTTGCCAAGATTGGGTCAATTTGACCGAAAAAGTTGATATGTCTTGGCAAGTACGCGTCAATGAAGTGATGGAAGAATTTACCACAAGGACCCCAGGTTCATTCATCGAAAGAAAGAAAGTCGCTCTAACTTGGCATTATAGACGTACCGTTCCAGAATTGGGTGAATTCCACGCCAAAGAACTGAAAGAAAAATTGTTATCATTTACTGATGACTTCGATTTAGAGGTCATGGATGGTAAAGCAAACATTGAAGTTCGTCCAAGATTCGTCAACAAAGGTGAAATAGTCAAGAGACTAGTCTGGCATCAACATGGCAAACCACAGGACATGTTGAAGGGAATCAGTGAAAAACTACCTAAGGATGAAATGCCTGATTTTGTATTATGTCTGGGTGATGACTTCACTGACGAAGACATGTTTAGACAGTTGAATACCATTGAAACTTGTTGGAAAGAAAAATATCCTGACCAAAAAAATCAATGGGGCAACTACGGATTCTATCCTGTCACTGTGGGATCTGCATCCAAGAAAACTGTCGCAAAGGCTCATTTAACCGATCCTCAGCAAGTCCTGGAGACTTTAGGTTTACTTGTTGGTGATGTCTCTCTCTTCCAAAGTGCTGGTACGGTCGACCTGGATTCCAGAGGTCATGTCAAGAATAGTGAGAGCAGTTTGAAATCAAAGCTAGCATCTAAAGCTTATGTTATGAAAAGATCGGCTTCTTACACCGGCGCAAAGGTTTGA","protein_sequence":"MTTTAQDNSPKKRQRIINCVTQLPYKIQLGESNDDWKISATTGNSALFSSLEYLQFDSTEYEQHVVGWTGEITRTERNLFTREAKEKPQDLDDDPLYLTKEQINGLTTTLQDHMKSDKEAKTDTTQTAPVTNNVHPVWLLRKNQSRWRNYAEKVIWPTFHYILNPSNEGEQEKNWWYDYVKFNEAYAQKIGEVYRKGDIIWIHDYYLLLLPQLLRMKFNDESIIIGYFHHAPWPSNEYFRCLPRRKQILDGLVGANRICFQNESFSRHFVSSCKRLLDATAKKSKNSSNSDQYQVSVYGGDVLVDSLPIGVNTTQILKDAFTKDIDSKVLSIKQAYQNKKIIIGRDRLDSVRGVVQKLRAFETFLAMYPEWRDQVVLIQVSSPTANRNSPQTIRLEQQVNELVNSINSEYGNLNFSPVQHYYMRIPKDVYLSLLRVADLCLITSVRDGMNTTALEYVTVKSHMSNFLCYGNPLILSEFSGSSNVLKDAIVVNPWDSVAVAKSINMALKLDKEEKSNLESKLWKEVPTIQDWTNKFLSSLKEQASSNDDMERKMTPALNRPVLLENYKQAKRRLFLFDYDGTLTPIVKDPAAAIPSARLYTILQKLCADPHNQIWIISGRDQKFLNKWLGGKLPQLGLSAEHGCFMKDVSCQDWVNLTEKVDMSWQVRVNEVMEEFTTRTPGSFIERKKVALTWHYRRTVPELGEFHAKELKEKLLSFTDDFDLEVMDGKANIEVRPRFVNKGEIVKRLVWHQHGKPQDMLKGISEKLPKDEMPDFVLCLGDDFTDEDMFRQLNTIETCWKEKYPDQKNQWGNYGFYPVTVGSASKKTVAKAHLTDPQQVLETLGLLVGDVSLFQSAGTVDLDSRGHVKNSESSLKSKLASKAYVMKRSASYTGAKV"},{"created_at":"2011-05-27T04:01:18.000Z","updated_at":"2011-05-27T15:01:22.000Z","name":"Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit","uniprot_id":"Q00764","uniprot_name":"TPS1_YEAST","enzyme":true,"transporter":false,"gene_name":"TPS1","num_residues":495,"molecular_weight":"56147.5","theoretical_pi":"6.0","general_function":"Involved in catalytic activity","specific_function":"Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. Can function independently of the complex","reactions":[{"id":2753,"direction":"\u003e","locations":"Cytoplasm","altext":"UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14365,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006883","source":"Smpdb"},{"id":14366,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006884","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AF061037","genbank_protein_id":"3150451","gene_card_id":"TPS1","chromosome_location":"chromosome 2","locus":"YBR126C","synonyms":["General glucose sensor subunit 1","Glycogen metabolism control protein GLC6","Trehalose synthase complex catalytic subunit TPS1","Trehalose-6-phosphate synthase","UDP-glucose-glucosephosphate glucosyltransferase"],"enzyme_classes":["2.4.1.15"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" UDP-glycosyltransferase activity"},{"category":"Function","description":" UDP-glucosyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" oligosaccharide metabolic process"},{"category":"Process","description":" disaccharide metabolic process"},{"category":"Process","description":" trehalose metabolic process"},{"category":"Process","description":" trehalose biosynthetic process"}],"pfams":[{"name":"Glyco_transf_20","identifier":"PF00982"}],"pathways":[{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"}],"gene_sequence":"ATGACTACGGATAACGCTAAGGCGCAACTGACCTCGTCTTCAGGGGGTAACATTATTGTGGTGTCCAACAGGCTTCCCGTGACAATCACTAAAAACAGCAGTACGGGACAGTACGAGTACGCAATGTCGTCCGGAGGGCTGGTCACGGCGTTGGAAGGGTTGAAGAAGACGTACACTTTCAAGTGGTTCGGATGGCCTGGGCTAGAGATTCCTGACGATGAGAAGGATCAGGTGAGGAAGGACTTGCTGGAAAAGTTTAATGCCGTACCCATCTTCCTGAGCGATGAAATCGCAGACTTACACTACAACGGGTTCAGTAATTCTATTCTATGGCCGTTATTCCATTACCATCCTGGTGAGATCAATTTCGACGAGAATGCGTGGTTGGCATACAACGAGGCAAACCAGACGTTCACCAACGAGATTGCTAAGACTATGAACCATAACGATTTAATCTGGGTGCATGATTACCATTTGATGTTGGTTCCGGAAATGTTGAGAGTCAAGATTCACGAGAAGCAACTGCAAAACGTTAAGGTCGGGTGGTTCCTGCACACACCATTCCCTTCGAGTGAAATTTACAGAATCTTACCTGTCAGACAAGAGATTTTGAAGGGTGTTTTGAGTTGTGATTTAGTCGGGTTCCACACATACGATTATGCAAGACATTTCTTGTCTTCCGTGCAAAGAGTGCTTAACGTGAACACATTGCCTAATGGGGTGGAATACCAGGGCAGATTCGTTAACGTAGGGGCCTTCCCTATCGGTATCGACGTGGACAAGTTCACCGATGGGTTGAAAAAGGAATCCGTACAAAAGAGAATCCAACAATTGAAGGAAACTTTCAAGGGCTGCAAGATCATAGTTGGTGTCGACAGGCTGGATTACATCAAAGGTGTGCCTCAGAAGTTGCACGCCATGGAAGTGTTTCTGAACGAGCATCCAGAATGGAGGGGCAAGGTTGTTCTGGTACAGGTTGCAGTGCCAAGTCGTGGAGATGTGGAAGAGTACCAATATTTAAGATCTGTGGTCAATGAGTTGGTCGGTAGAATCAACGGTCAGTTCGGTACTGTGGAATTCGTCCCCATCCATTTCATGCACAAGTCTATACCATTTGAAGAGCTGATTTCGTTATATGCTGTGAGCGATGTTTGTTTGGTCTCGTCCACCCGTGATGGTATGAACTTGGTTTCCTACGAATATATTGCTTGCCAAGAAGAAAAGAAAGGTTCCTTAATCCTGAGTGAGTTCACAGGTGCCGCACAATCCTTGAATGGTGCTATTATTGTAAATCCTTGGAACACCGATGATCTTTCTGATGCCATCAACGAGGCCTTGACTTTGCCCGATGTAAAGAAAGAAGTTAACTGGGAAAAACTTTACAAATACATCTCTAAATACACTTCTGCCTTCTGGGGTGAAAATTTCGTCCATGAATTATACAGTACATCATCAAGCTCAACAAGCTCCTCTGCCACCAAAAACTGA","protein_sequence":"MTTDNAKAQLTSSSGGNIIVVSNRLPVTITKNSSTGQYEYAMSSGGLVTALEGLKKTYTFKWFGWPGLEIPDDEKDQVRKDLLEKFNAVPIFLSDEIADLHYNGFSNSILWPLFHYHPGEINFDENAWLAYNEANQTFTNEIAKTMNHNDLIWVHDYHLMLVPEMLRVKIHEKQLQNVKVGWFLHTPFPSSEIYRILPVRQEILKGVLSCDLVGFHTYDYARHFLSSVQRVLNVNTLPNGVEYQGRFVNVGAFPIGIDVDKFTDGLKKESVQKRIQQLKETFKGCKIIVGVDRLDYIKGVPQKLHAMEVFLNEHPEWRGKVVLVQVAVPSRGDVEEYQYLRSVVNELVGRINGQFGTVEFVPIHFMHKSIPFEELISLYAVSDVCLVSSTRDGMNLVSYEYIACQEEKKGSLILSEFTGAAQSLNGAIIVNPWNTDDLSDAINEALTLPDVKKEVNWEKLYKYISKYTSAFWGENFVHELYSTSSSSTSSSATKN"},{"created_at":"2011-05-27T06:37:07.000Z","updated_at":"2011-05-27T15:01:26.000Z","name":"Trehalose synthase complex regulatory subunit TPS3","uniprot_id":"P38426","uniprot_name":"TPS3_YEAST","enzyme":true,"transporter":false,"gene_name":"TPS3","num_residues":1054,"molecular_weight":"118834.0","theoretical_pi":"6.32","general_function":"Involved in catalytic activity","specific_function":"Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex","reactions":[{"id":14365,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006883","source":"Smpdb"},{"id":14366,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006884","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692968","genbank_protein_id":"51013387","gene_card_id":"TPS3","chromosome_location":"chromosome 13","locus":"YMR261C","synonyms":["Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 115 kDa subunit"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" oligosaccharide metabolic process"},{"category":"Process","description":" disaccharide metabolic process"},{"category":"Process","description":" trehalose metabolic process"},{"category":"Process","description":" trehalose biosynthetic process"}],"pfams":[{"name":"Glyco_transf_20","identifier":"PF00982"},{"name":"Trehalose_PPase","identifier":"PF02358"}],"pathways":[{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"}],"gene_sequence":"ATGACTATTATCGTCGCTTCTTTATTCTTACCATATACCCCTCAATTCGAGGCTGATGTCACCAACTCGGATACTGCTAAGCTGGTTGAATCAAGTATGATCAAGGTAGACTGCAACAACCAGGAATTGAGCAACAACAAGCAAGAAAGAAGCAGTTCTGTAACTTCGGCAAGCTCTCATTATATTGGCTTACCTCAGGAGGCGCAAATTAACGGTGAACCCTTACAAAGGGCCAATGTGGGCTCTCCTGCTACGGGAGTTAACTATCATAATGAGATGGAAATGCTTTCCTCAGAGCAATTCCTGGAAGAGCTGACTGCCAATGCCACTCATGCAGCAAACTCTGGTATTCCGCCAGCTAATAACCCAGTTTCTTCTGGCTCAACTGCCCAGCGGCCTTCAGTCGAGGAATTCTTTTCTGCTCCGTCTGCTAGAGTCTGTTCTCCCTCCCAGGAAGCTTCTGCTTCGTCTATTTCTGCTAGTCGTTCATCGGCTCACCACAACGATTTGAGCTCCAGCCTTATGAAAAATCCCAATTTGTCATTTGATTCACATCCACCCAGGGTCAGAAGCTCATCCAAGAGTGCTGTAATCACTCCCGTCTCTAAAAGCGTTCCAGATGTCGATCCTGCTGTTGTAGATGTCGCAAAAGTTAGAGAAGAGTTTCAACAGCAAGCCTCCTTGCCTTCCATGAAAAGAGTTTCCGGAAGCACCGCTGGAGACTCTTCCATTGCTTCTTCGAGTTCTAATCTCAGGTACTCACAGCAATTTCAGGATAACTTTATCGAAGACACTGATAGTGAGGATGACATTGATTCTGATTTGGAGACCGATGCTACTAAGAAATACAACGTCCCAAAATTTGGTGGCTATTCCAATAACGCAAAGTTAAGAGCATCTCTAATGAGAAACTCGTATGAGCTATTCAAACATTTGCCATGGACAATAGTCGACAGTGACAAAGGGAACGGATCCTTGAAAAATGCAGTTAATATTGCAGTTGCTGAAAAGACAGTGAAAGAACCTGTTTCCTGGGTAGGTACAATGGGAATCCCTACTGACGAACTTCCTCACGAAGTTTGCCATAAGATTTCAAAGAAATTAGAACAGGATTTTTCTTCTTTTCCAGTGGTCACGGACGATATTACTTTTAAGGGTGCTTATAAGAACTACGCCAAACAGATTTTATGGCCCACTCTACATTATCAAATTCCAGATAATCCAAATTCAAAGGCTTTTGAAGACCATTCTTGGGACTACTATCAAAAAGTGAATCAAAAGTTTTCTGATAGGATAGTTTCCGTTTACAAACCTGGCGACACAATTTGGATCCATGATTATCATTTGATGCTTGTCCCACAAATGGTGAGAGAGAAACTGCCTAAAGCTAAGATTGGATTTTTCTTACACGTATCATTTCCAAGTAGTGAGGTCTTCAGATGCCTTGCTAACAGAGAAAGGATTCTTGAAGGTATTATTGGTGCAAACTTTGTTGGGTTTCAAACTAAAGAATACAAAAGACATTTCCTACAAACTTGTAACAGATTGCTTGCTGCGGATGTCTCTAATGATGAAGTCAAATACCATTGCAATATTGTTTCCGTGATGTATGCGCCAATTGGTATTGATTATTACCATTTGACATCGCAGTTGAGAAATGGTTCTGTACTTGAATGGCGCCAATTAATTAAAGAAAGATGGCGTAATAAAAAACTGATTGTTTGTCGCGATCAATTTGACAGAATTAGAGGTCTTCAGAAAAAAATGTTAGCCTACGAGAGGTTTTTGATAGAAAACCCTGAATACATCGAAAAAGTTGTTTTGATCCAAATCTGCATCGGTAAGAGTTCCGATCCTGAGTACGAACGTCAAATTATGGTTGTCGTTGATAGAATCAATTCTTTGTCTTCGAACATCAGTATCTCTCAACCAGTGGTCTTTTTGCATCAAGATTTAGATTTTGCTCAATATTTGGCATTGAATTGTGAAGCTGACGTTTTCCTTGTGGATGCGCTGAGAGAAGGTATGAATTTAACATGTCATGAGTTCATTGTCAGTTCATTCGAAAAAAATGCGCCTCTATTATTATCTGAATTCACTGGTAGTTCTTCTGTCCTAAAGGAAGGTGCCATCTTAATAAACCCATGGGATATAAATCATGTAGCACAAAGTATCAAGAGAAGTTTAGAAATGTCTCCAGAAGAAAAAAGGCGTAGGTGGAAAAAATTATTCAAATCTGTTATTGAACATGATTCGGATAATTGGATTACAAAGTGCTTCGAATACATAAATAATGCTTGGGAGTCCAACCAAGAAACGTCTACTGTTTTCAATTTGGCTCCAGAAAAATTCTGTGCTGATTACAAAGCCTCCAAAAAGCATTTATTTATCTTCAAGATTTCAGAACCTCCAACGTCCAGAATGCTATCCTTGCTAAGTGAATTGAGTTCAAATAATATAGTTTACGTTTTGAGTTCATTTACAAAGAATACATTCGAAAGCTTATACAATGGTGTTCTAAACATCGGATTGATAGCGGAGAATGGTGCCTACGTAAGAGTTAATGGGTCGTGGTACAACATCGTGGAAGAGCTTGATTGGATGAAAGAGGTGGCAAAGATCTTTGACGAGAAAGTCGAGAGGTTACCTGGTTCATACTACAAAATCGCTGATTCTATGATCAGATTCCATACAGAAAACGCTGATGATCAAGATCGAGTCCCAACTGTTATTGGGGAAGCCATTACGCACATAAACACCTTATTTGATGACAGGGATATTCACGCTTATGTGCATAAGGATATTGTCTTCGTTCAACAAACGGGGCTAGCCTTAGCCGCCGCTGAGTTTTTGATGAAATTTTACAACAGTGGCGTCAGTCCTACTGACAATAGCAGAATATCTCTATCAAGAACATCCTCTTCGATGTCCGTCGGTAATAATAAGAAGCATTTCCAAAACCAGGTAGATTTCGTTTGCGTTTCCGGTTCGACATCACCTATTATTGAACCATTATTTAAATTAGTGAAGCAAGAGGTTGAAAAGAACAATCTAAAATTTGGTTACACCATTCTTTACGGTAGCTCAAGATCCACTTATGCCAAGGAACATATCAATGGTGTCAATGAACTTTTTACCATCCTTCATGACTTGACAGCCGCCTAA","protein_sequence":"MTIIVASLFLPYTPQFEADVTNSDTAKLVESSMIKVDCNNQELSNNKQERSSSVTSASSHYIGLPQEAQINGEPLQRANVGSPATGVNYHNEMEMLSSEQFLEELTANATHAANSGIPPANNPVSSGSTAQRPSVEEFFSAPSARVCSPSQEASASSISASRSSAHHNDLSSSLMKNPNLSFDSHPPRVRSSSKSAVITPVSKSVPDVDPAVVDVAKVREEFQQQASLPSMKRVSGSTAGDSSIASSSSNLRYSQQFQDNFIEDTDSEDDIDSDLETDATKKYNVPKFGGYSNNAKLRASLMRNSYELFKHLPWTIVDSDKGNGSLKNAVNIAVAEKTVKEPVSWVGTMGIPTDELPHEVCHKISKKLEQDFSSFPVVTDDITFKGAYKNYAKQILWPTLHYQIPDNPNSKAFEDHSWDYYQKVNQKFSDRIVSVYKPGDTIWIHDYHLMLVPQMVREKLPKAKIGFFLHVSFPSSEVFRCLANRERILEGIIGANFVGFQTKEYKRHFLQTCNRLLAADVSNDEVKYHCNIVSVMYAPIGIDYYHLTSQLRNGSVLEWRQLIKERWRNKKLIVCRDQFDRIRGLQKKMLAYERFLIENPEYIEKVVLIQICIGKSSDPEYERQIMVVVDRINSLSSNISISQPVVFLHQDLDFAQYLALNCEADVFLVDALREGMNLTCHEFIVSSFEKNAPLLLSEFTGSSSVLKEGAILINPWDINHVAQSIKRSLEMSPEEKRRRWKKLFKSVIEHDSDNWITKCFEYINNAWESNQETSTVFNLAPEKFCADYKASKKHLFIFKISEPPTSRMLSLLSELSSNNIVYVLSSFTKNTFESLYNGVLNIGLIAENGAYVRVNGSWYNIVEELDWMKEVAKIFDEKVERLPGSYYKIADSMIRFHTENADDQDRVPTVIGEAITHINTLFDDRDIHAYVHKDIVFVQQTGLALAAAEFLMKFYNSGVSPTDNSRISLSRTSSSMSVGNNKKHFQNQVDFVCVSGSTSPIIEPLFKLVKQEVEKNNLKFGYTILYGSSRSTYAKEHINGVNELFTILHDLTAA"},{"created_at":"2011-07-22T05:30:31.000Z","updated_at":"2011-07-22T05:30:31.000Z","name":"Trehalose synthase complex regulatory subunit TSL1","uniprot_id":"P38427","uniprot_name":"TSL1_YEAST","enzyme":false,"transporter":false,"gene_name":"TSL1","num_residues":1098,"molecular_weight":"123017.0","theoretical_pi":"6.61","general_function":"Carbohydrate transport and metabolism","specific_function":"Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex, and confer sensitivity to physiological concentrations of phosphate and to fructose 6- phosphate","reactions":[{"id":14365,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006883","source":"Smpdb"},{"id":14366,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006884","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X72788","genbank_protein_id":"288437","gene_card_id":"TSL1","chromosome_location":null,"locus":null,"synonyms":["Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 123 kDa subunit"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"catalytic activity"},{"category":"Process","description":"metabolic process"},{"category":"Process","description":"primary metabolic process"},{"category":"Process","description":"carbohydrate metabolic process"},{"category":"Process","description":"oligosaccharide metabolic process"},{"category":"Process","description":"disaccharide metabolic process"},{"category":"Process","description":"trehalose metabolic process"},{"category":"Process","description":"trehalose biosynthetic process"}],"pfams":[{"name":"Glyco_transf_20","identifier":"PF00982"},{"name":"Trehalose_PPase","identifier":"PF02358"}],"pathways":[{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"}],"gene_sequence":"ATGGCTCTCATCGTGGCATCTTTGTTTTTGCCCTACCAACCACAATTCGAGCTTGACACCTCTCTCCCTGAGAACTCGCAGGTGGACTCATCTCTCGTGAACATCCAGGCTATGGCCAATGACCAACAGCAACAACGTGCGCTTTCTAACAACATCTCACAGGAATCATTGGTCGCGCCAGCACCAGAACAAGGTGTCCCCCCAGCAATCTCAAGGAGTGCCACCAGGTCACCCAGTGCTTTCAACCGCGCCTCGTCTACGACAAATACTGCCACTTTAGATGATCTTGTCTCTTCGGACATATTCATGGAAAACTTGACTGCGAATGCAACTACCTCACATACGCCAACAAGCAAGACTATGCTTAAACCCCGGAAAAATGGTTCCGTGGAACGATTCTTCTCCCCTTCTTCCAATATTCCCACGGATCGCATCGCATCGCCAATCCAGCATGAGCATGACTCCGGTTCGAGAATTGCTTCGCCAATCCAACAGCAACAGCAGGACCCCACGACCAACTTATTAAAGAACGTCAACAAGTCATTGTTAGTGCACTCACTGTTGAACAACACCTCACAAACTAGCCTAGAAGGACCCAACAACCACATTGTTACCCCGAAATCGAGGGCGGGCAACAGGCCTACTTCGGCGGCTACTTCTTTAGTTAATAGGACCAAACAAGGTTCGGCCTCCTCTGGATCTTCTGGGTCTTCTGCGCCACCTTCCATTAAAAGGATTACGCCCCACTTGACTGCGTCTGCTGCAAAACAGCGTCCCTTATTGGCTAAACAGCCTTCTAATCTGAAATATTCGGAGTTAGCAGATATTTCGTCGAGTGAGACGTCTTCGCAGCATAATGAGTCGGACCCGGATGATCTAACTACTGCCCCTGACGAGGAATATGTTTCTGATTTGGAAATGGATGACGCGAAGCAGGACTACAAGGTTCCAAAGTTCGGCGGCTATTCCAATAAATCTAAACTTAAGAAATATGCGCTGTTAAGGTCATCTCAGGAGCTGTTTAGCCGTCTTCCATGGTCGATCGTTCCCTCTATCAAAGGTAATGGCGCCATGAAGAACGCCATAAACACTGCAGTCTTGGAGAATATCATTCCGCACCGTCATGTTAAGTGGGTCGGTACCGTCGGAATCCCAACGGATGAGATTCCGGAAAATATCCTTGCGAACATCTCTGACTCTTTAAAAGACAAGTACGACTCCTATCCTGTCCTTACGGACGACGACACCTTCAAAGCCGCATACAAAAACTACTGTAAACAAATCTTGTGGCCTACGCTGCATTACCAGATTCCAGACAATCCGAACTCGAAGGCTTTTGAAGATCACTCTTGGAAGTTCTATAGAAACTTAAACCAAAGGTTTGCGGACGCGATCGTTAAAATCTATAAGAAAGGTGACACCATCTGGATTCATGATTACCATTTAATGCTGGTTCCGCAGATGGTGAGAGACGTCTTGCCTTTTGCCAAAATAGGATTTACCTTACATGTCTCGTTCCCCAGTAGTGAAGTGTTTAGGTGTCTGGCTCAGCGTGAGAAGATCTTAGAAGGCTTGACCGGTGCAGACTTTGTCGGCTTCCAGACGAGGGAGTATGCAAGACATTTCTTACAGACGTCTAACCGTCTGCTAATGGCGGACGTGGTACATGATGAAGAGCTAAAGTATAACGGCAGAGTCGTTTCTGTGAGGTTCACCCCAGTTGGTATCGACGCCTTTGATTTGCAATCGCAATTGAAGGATGGAAGTGTCATGCAATGGCGTCAATTGATTCGTGAAAGATGGCAAGGGAAAAAACTAATTGTGTGTCGTGATCAATTCGATAGAATTAGAGGTATTCACAAGAAATTGTTGGCTTATGAAAAATTCTTGGTCGAAAATCCGGAATACGTGGAAAAATCGACTTTAATTCAAATCTGTATTGGAAGCAGTAAGGATGTAGAACTGGAGCGCCAGATCATGATTGTCGTGGATAGAATCAACTCGCTATCCACCAATATTAGTATTTCTCAACCTGTGGTGTTTTTGCATCAAGATCTAGATTTTTCTCAGTATTTAGCTTTGAGTTCAGAGGCAGATTTGTTCGTAGTCAGCTCTCTAAGGGAAGGTATGAACTTGACATGTCACGAATTTATCGTTTGTTCTGAGGACAAAAATGCTCCCCTACTGTTGTCAGAATTTACTGGTAGTGCATCTTTATTGAATGATGGCGCTATAATAATTAACCCATGGGATACCAAGAACTTCTCACAAGCCATTCTCAAGGGGTTGGAGATGCCATTCGATAAGAGAAGGCCACAGTGGAAGAAATTGATGAAAGACATTATCAACAACGACTCTACAAACTGGATCAAGACTTCTTTACAAGATATTCATATTTCGTGGCAATTCAATCAAGAAGGTTCCAAGATCTTCAAATTGAATACAAAAACACTGATGGAAGATTACCAGTCATCTAAAAAGCGTATGTTTGTTTTCAACATTGCTGAACCACCTTCATCGAGAATGATTTCCATACTGAATGACATGACTTCTAAGGGCAATATCGTTTACATCATGAACTCATTTCCAAAGCCCATTCTGGAAAATCTTTACAGTCGTGTGCAAAACATTGGGTTGATTGCCGAGAATGGTGCATACGTTAGTCTGAACGGTGTATGGTACAACATTGTTGATCAAGTCGATTGGCGTAACGATGTAGCCAAAATTCTCGAGGACAAAGTGGAGAGATTACCTGGCTCGTACTACAAGATAAATGAGTCCATGATCAAGTTCCACACTGAAAATGCGGAAGATCAAGATCGTGTAGCTAGTGTTATCGGTGATGCCATCACACATATCAATACTGTTTTTGACCACAGAGGTATTCATGCCTACGTTTACAAAAACGTTGTTTCCGTACAACAAGTGGGACTTTCCTTATCGGCAGCTCAATTTCTTTTCAGATTCTATAATTCTGCTTCGGATCCACTGGATACGAGTTCCGGCCAAATCACAAATATTCAGACACCATCTCAACAAAATCCTTCAGATCAAGAACAACAACCTCCAGCCTCTCCCACTGTGTCGATGAACCATATTGATTTCGCATGTGTCTCTGGTTCATCGTCTCCTGTGCTTGAACCATTGTTCAAATTGGTCAATGATGAAGCAAGTGAAGGGCAAGTAAAAGCCGGACACGCCATTGTTTATGGTGATGCTACTTCTACTTATGCCAAAGAACATGTAAATGGGTTAAACGAACTTTTCACGATCATTTCAAGAATCATTGAAGATTAA","protein_sequence":"MALIVASLFLPYQPQFELDTSLPENSQVDSSLVNIQAMANDQQQQRALSNNISQESLVAPAPEQGVPPAISRSATRSPSAFNRASSTTNTATLDDLVSSDIFMENLTANATTSHTPTSKTMLKPRKNGSVERFFSPSSNIPTDRIASPIQHEHDSGSRIASPIQQQQQDPTTNLLKNVNKSLLVHSLLNNTSQTSLEGPNNHIVTPKSRAGNRPTSAATSLVNRTKQGSASSGSSGSSAPPSIKRITPHLTASAAKQRPLLAKQPSNLKYSELADISSSETSSQHNESDPDDLTTAPDEEYVSDLEMDDAKQDYKVPKFGGYSNKSKLKKYALLRSSQELFSRLPWSIVPSIKGNGAMKNAINTAVLENIIPHRHVKWVGTVGIPTDEIPENILANISDSLKDKYDSYPVLTDDDTFKAAYKNYCKQILWPTLHYQIPDNPNSKAFEDHSWKFYRNLNQRFADAIVKIYKKGDTIWIHDYHLMLVPQMVRDVLPFAKIGFTLHVSFPSSEVFRCLAQREKILEGLTGADFVGFQTREYARHFLQTSNRLLMADVVHDEELKYNGRVVSVRFTPVGIDAFDLQSQLKDGSVMQWRQLIRERWQGKKLIVCRDQFDRIRGIHKKLLAYEKFLVENPEYVEKSTLIQICIGSSKDVELERQIMIVVDRINSLSTNISISQPVVFLHQDLDFSQYLALSSEADLFVVSSLREGMNLTCHEFIVCSEDKNAPLLLSEFTGSASLLNDGAIIINPWDTKNFSQAILKGLEMPFDKRRPQWKKLMKDIINNDSTNWIKTSLQDIHISWQFNQEGSKIFKLNTKTLMEDYQSSKKRMFVFNIAEPPSSRMISILNDMTSKGNIVYIMNSFPKPILENLYSRVQNIGLIAENGAYVSLNGVWYNIVDQVDWRNDVAKILEDKVERLPGSYYKINESMIKFHTENAEDQDRVASVIGDAITHINTVFDHRGIHAYVYKNVVSVQQVGLSLSAAQFLFRFYNSASDPLDTSSGQITNIQTPSQQNPSDQEQQPPASPTVSMNHIDFACVSGSSSPVLEPLFKLVNDEASEGQVKAGHAIVYGDATSTYAKEHVNGLNELFTIISRIIED"}]}