{"ymdb_id":"YMDB00133","created_at":"2011-05-29T16:00:02.000Z","updated_at":"2016-09-08T18:35:04.000Z","name":"Phosphatidylinositol 4,5-bisphosphate","cas":"245126-95-8","state":null,"melting_point":null,"description":"Phosphatidylinositol 4,5-bisphosphate is a phosphorylated derivative of phosphatidylinositol or phosphoinositides (PIs). Phosphoinositides are eukaryotic cell membrane phospholipids playing a key role in signal transduction. [Biocyc PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cytoplasm, Endoplasmic Reticulum, Plasma Membrane","synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":"24742074","cs_id":"25057264","foodb_id":null,"wikipedia_link":"Phosphatidylinositol_4,5-bisphosphate","biocyc_id":null,"iupac":null,"traditional_iupac":null,"logp":"9.966649190666669","pka":"1.2072584645996232","alogps_solubility":"2.90e-02 g/l","alogps_logp":"6.52","alogps_logs":"-4.59","acceptor_count":"13","donor_count":"3","rotatable_bond_count":"44","polar_surface_area":"316.72","refractivity":"258.77750000000003","polarizability":"111.21625374799956","formal_charge":"-5","physiological_charge":"-5","pka_strongest_basic":"-3.6679537745918793","pka_strongest_acidic":"0.626767162474474","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":4353706,"citation":"Talwalkar, R. T., Lester, R. L. (1973). \"The response of diphosphoinositide and triphosphoinostitide to perturbations of the adenylate energy charge in cells of Saccharomyces cerevisiae.\" Biochim Biophys Acta 306:412-421."},{"pubmed_id":2835684,"citation":"Uno, I., Fukami, K., Kato, H., Takenawa, T., Ishikawa, T. (1988). \"Essential role for phosphatidylinositol 4,5-bisphosphate in yeast cell proliferation.\" Nature 333:188-190."}],"proteins":[{"created_at":"2011-05-27T02:23:01.000Z","updated_at":"2011-05-29T05:06:35.000Z","name":"Probable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TEP1","uniprot_id":"P53916","uniprot_name":"TEP1_YEAST","enzyme":true,"transporter":false,"gene_name":"TEP1","num_residues":434,"molecular_weight":"50151.5","theoretical_pi":"6.79","general_function":"Involved in protein tyrosine/serine/threonine phosphatase activity","specific_function":"May act as a phosphoinositide 3-phosphatase by regulating PtdIns(3,4,5)P3 levels","reactions":[{"id":2673,"direction":"\u003e","locations":"Cytoplasmic","altext":"Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"Z46843","genbank_protein_id":"854509","gene_card_id":"TEP1","chromosome_location":"chromosome 14","locus":"YNL128W","synonyms":[],"enzyme_classes":["3.1.3.67"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" protein tyrosine phosphatase activity"},{"category":"Function","description":" phosphoprotein phosphatase activity"},{"category":"Function","description":" protein tyrosine/serine/threonine phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" phosphorus metabolic process"},{"category":"Process","description":" phosphate metabolic process"},{"category":"Process","description":" dephosphorylation"},{"category":"Process","description":" protein amino acid dephosphorylation"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"DSPc","identifier":"PF00782"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"}],"gene_sequence":"ATGAGAGAGGAGGGGAGTGAATTAGAAATGGAAAAAGGCTTCCTTAAATGGAAACCAGTCAACTTGATGAAGAAAATATTGTCTTTACCAATGAAAAAAACTAAAAACGATATAGGTTTGAGATTAGATATATCATATATTTTAGTTAATCTAATAGTCTGCTCATACCCGGTAAACACGTATCCAAAACTGCTTTATAGGAATAGCTTGGATGACTTAATATTGTTTCTAACAGTGTACCATGGCAAGGGAAATTTTAGAATTTTTAATTTTAGAGGTGAGAAAGAAGACAGCGATTATAAAGATAATGATCTTATTGGTATCGCTGCCAAGTTTGAGAGCAAAGATTTTGAAATTCAAGAATTACGTTCGACGCTGATTAATGATGGAAAGATACCAATATCACCCATTGATCTCGAAACAAGGACCTTGGTCGAAGAAGAAACCAATAATGTAATTTGTGAAAGGATCGGTTGGCTAGATCATTTTCCACCGCCATTTGAACTGCTGGAAGAGATTGTAGATGGTATAGAAAATTACCTGTCCGTTTCGAAGAATAGAGTGGCTGTTTTACATTGTCGAATGGGGAAAGGCCGATCTGGTATGATAACAGTAGCATACCTCATGAAATACTTGCAGTGTCCTCTTGGAGAAGCAAGATTGATATTCATGCAGGCTAGATTCAAGTATGGTATGACGAATGGCGTCACCATACCCTCTCAATTAAGATACTTAAGGTACCATGAGTTTTTTATTACCCATGAAAAAGCAGCCCAAGAAGGAATTTCTAATGAGGCGGTAAAATTCAAATTTAAATTCAGGCTTGCTAAAATGACGTTCCTCCGCCCATCAAGCTTAATCACTTCCGAGTCTGCTATTGTAACTACTAAGATTCAACACTACAACGATGATAGAAATGCCCTCCTAACCCGAAAAGTAGTATATTCAGATATCATGGCGCATGAATGCGGTGGTAATATGACCTTCATTTTTGGTAGGGACTACTTAACACTGGAAAATGATTGTCGTATAGAATTTACCCTGGGGACCAGCAAGTCCAAAGCCGCCAGTAGCATAATATCTTGGACTTCATGCGCCAGCTGTTGGCTGAATATATACCTTGAGACTTTGATGCACATAATTAAAGACGATTCTTCGCCAGATTACTTTCAAGTAGAGAGGTTAAAGAGAGACGAAATGCTTGGAACAACCATAAGCTGGCAAGAGCTGGACGGTTTTGGGGAGCTCAGCACTCACGGCTTGAAATTATTTCAGGCACTGAAATTGGAATGGGAAATTATATAG","protein_sequence":"MREEGSELEMEKGFLKWKPVNLMKKILSLPMKKTKNDIGLRLDISYILVNLIVCSYPVNTYPKLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKDNDLIGIAAKFESKDFEIQELRSTLINDGKIPISPIDLETRTLVEEETNNVICERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKYGMTNGVTIPSQLRYLRYHEFFITHEKAAQEGISNEAVKFKFKFRLAKMTFLRPSSLITSESAIVTTKIQHYNDDRNALLTRKVVYSDIMAHECGGNMTFIFGRDYLTLENDCRIEFTLGTSKSKAASSIISWTSCASCWLNIYLETLMHIIKDDSSPDYFQVERLKRDEMLGTTISWQELDGFGELSTHGLKLFQALKLEWEII"}]}