{"ymdb_id":"YMDB00126","created_at":"2011-05-29T15:59:21.000Z","updated_at":"2016-10-18T17:11:18.000Z","name":"L-Tryptophan","cas":"73-22-3","state":"Solid","melting_point":"230 oC","description":"Tryptophan (abbreviated as Trp or W) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a nonpolar, aromatic amino acid, because of the hydrophobic nature of the indole side chain. L-Tryptophan is an electrically neutral amino acid. Tryptophan is synthesized from shikimic acid or anthranilate. The latter condenses with phosphoribosylpyrophosphate (PRPP), generating pyrophosphate as a by-product. After ring opening of the ribose moiety and following reductive decarboxylation, indole-3-glycerinephosphate is produced, which in turn is transformed into indole. In the last step, tryptophan synthase catalyzes the formation of tryptophan from indole and the amino acid serine. S. cerevisiae degrade the aromatic amino acids (tryptophan, phenylalanine, and tyrosine) via the Ehrlich pathway.  This pathway consists of 3 steps: 1) deamination of the amino acid to the corresponding alpha-keto acid; 2) decarboxylation of the resulting alpha-keto acid to the respective aldehyde; and, 3) reduction of the aldehyde to form the corresponding long chain or complex alcohol, known as a fusel alcohol or fusel oil. Fusel alcohols are important flavor and aroma compounds in yeast-fermented food products and beverages. The primary aminotransferase in tryptophan degradation is postulated to be Aro9p. In vitro studies demonstrated that Aro9p is active with phenylpyruvate, pyruvate, or p-hydroxyphenylpyruvate, but not 2-oxoglutarate as the amino acceptor. Aro9p is induced by aromatic amino acids and is subject to nitrogen regulation.","experimental_water_solubility":"13.4 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-1.06 [HANSCH,C ET AL. (1995)]","location":"extracellular;mitochondrion;cytoplasm","synthesis_reference":"Amir-Heidari, Bagher; Thirlway, Jenny; Micklefield, Jason. Stereochemical course of tryptophan dehydrogenation during biosynthesis of the calcium-dependent lipopeptide antibiotics. Organic Letters  (2007),  9(8),  1513-1516.","chebi_id":"16828","hmdb_id":"HMDB00929","kegg_id":"C00078","pubchem_id":"6305","cs_id":"6066","foodb_id":null,"wikipedia_link":"Tryptophan","biocyc_id":"TRP","iupac":"(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid","traditional_iupac":"L-tryptophan","logp":"-1.0854569138833579","pka":"16.1565885064574","alogps_solubility":"1.36e+00 g/l","alogps_logp":"-1.10","alogps_logs":"-2.18","acceptor_count":"3","donor_count":"3","rotatable_bond_count":"3","polar_surface_area":"79.11","refractivity":"56.20280000000001","polarizability":"21.047414013171778","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.396082567807317","pka_strongest_acidic":"2.5439286383469866","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(-)-tryptophan","(2S)-2-amino-3-(1H-indol-3-yl)propanoate","(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid","(l)-tryptophan","(S)-1H-Indole-3-alanine","(S)-2-Amino-3-(3-indolyl)propionic acid","(S)-a-Amino-1H-indole-3-propanoate","(S)-a-Amino-1H-indole-3-propanoic acid","(s)-a-amino-b-indolepropionate","(s)-a-amino-b-indolepropionic acid","(S)-a-Aminoindole-3-propionate","(S)-a-Aminoindole-3-propionic acid","(S)-alpha-Amino-1H-indole-3-propanoate","(S)-alpha-Amino-1H-indole-3-propanoic acid","(S)-alpha-Amino-beta-(3-indolyl)-propionic acid","(s)-alpha-amino-beta-indolepropionate","(s)-alpha-amino-beta-indolepropionic acid","(S)-alpha-Aminoindole-3-propionate","(S)-alpha-Aminoindole-3-propionic acid","(s)-tryptophan","1-beta-3-Indolylalanine","1beta-3-Indolylalanine","1H-Indole-3-Alanine","2-Amino-3-indolylpropanoate","2-Amino-3-indolylpropanoic acid","3-(1H-indol-3-yl)-L-Alanine","3-Indol-3-ylalanine","alpha-Aminoindole-3-propionic acid","alpha'-Amino-3-indolepropionic acid","Ardeytropin","H-TRP-oh","Indole-3-alanine","Kalma","L-(-)-tryptophan","L-alpha-amino-3-indolepropionic acid","L-alpha-aminoindole-3-propionic acid","l-b-3-Indolylalanine","L-beta-3-indolylalanine","L-tryptofan","L-Tryptophan","L-tryptophane","Lyphan","Optimax","Pacitron","Sedanoct","Triptofano","Trofan","Tryptacin","Tryptan","Tryptophan","Tryptophane","Tryptophanum"],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"NAD metabolism","kegg_map_id":null}],"growth_conditions":[{"growth_media":"YEB media with 0.5 mM glucose","concentration":"451.0","concentration_units":"\u0026#181;M","error":"23.0"},{"growth_media":"Synthetic medium with 20 g/L glucose","concentration":"240.0","concentration_units":"\u0026#181;M","error":"70.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"0.51","concentration_units":"umol/g DW","error":"0.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":19001417,"citation":"Belenky, P., Christensen, K. C., Gazzaniga, F., Pletnev, A. A., Brenner, C. (2009). \"Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism.\" J Biol Chem 284:158-164."},{"pubmed_id":12902239,"citation":"Vuralhan, Z., Morais, M. A., Tai, S. L., Piper, M. D., Pronk, J. T. (2003). \"Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae.\" Appl Environ Microbiol 69:4534-4541."},{"pubmed_id":10935926,"citation":"Vaseghi, S., Baumeister, A., Rizzi, M., Reuss, M. (1999). \"In vivo dynamics of the pentose phosphate pathway in Saccharomyces cerevisiae.\" Metab Eng 1:128-140."},{"pubmed_id":12584756,"citation":"Hans, M. A., Heinzle, E., Wittmann, C. (2003). \"Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.\" Biotechnol Bioeng 82:143-151."},{"pubmed_id":9573211,"citation":"Schreve, J. L., Sin, J. K., Garrett, J. M. (1998). \"The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine.\" J Bacteriol 180:2556-2559."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."},{"pubmed_id":12062417,"citation":"Panozzo, C., Nawara, M., Suski, C., Kucharczyka, R., Skoneczny, M., Becam, A. M., Rytka, J., Herbert, C. J. (2002). \"Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae.\" FEBS Lett 517:97-102."},{"pubmed_id":9491083,"citation":"Iraqui, I., Vissers, S., Cartiaux, M., Urrestarazu, A. (1998). \"Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily.\" Mol Gen Genet 257:238-248."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T20:11:48.000Z","updated_at":"2011-05-27T14:56:00.000Z","name":"Tryptophan permease","uniprot_id":"P38967","uniprot_name":"TAT2_YEAST","enzyme":false,"transporter":true,"gene_name":"TAT2","num_residues":592,"molecular_weight":"65403.80078","theoretical_pi":"8.42","general_function":"Involved in transport","specific_function":"Required for high-affinity tryptophan transport. Also transports cysteine, phenyalanine and tyrosine","reactions":[],"signal_regions":"None","transmembrane_regions":"88-108;114-134;161-181;193-213;227-247;267-287;307-327;359-379;405-425;429-449;473-493;515-535","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"D16304","genbank_protein_id":"1113091","gene_card_id":"TAT2","chromosome_location":"chromosome 15","locus":"YOL020W","synonyms":["Tryptophan amino acid transporter"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGACCGAAGACTTTATTTCTTCTGTCAAGCGTTCAAATGAGGAGCTGAAGGAGCGAAAATCTAACTTTGGATTTGTAGAATACAAATCCAAGCAATTAACATCATCCTCATCACACAATTCAAACTCATCGCATCACGATGATGACAACCAACACGGCAAGAGGAATATTTTCCAGCGATGTGTTGATTCTTTCAAGTCTCCTCTGGACGGCTCGTTCGACACAAGTAATTTGAAGAGGACTCTGAAACCAAGGCACTTAATCATGATTGCCATTGGGGGCAGTATAGGTACTGGTTTGTTTGTCGGTAGTGGTAAGGCAATCGCCGAAGGTGGTCCTCTTGGTGTCGTCATTGGTTGGGCTATTGCAGGCTCTCAAATCATCGGGACGATTCATGGGCTAGGTGAAATCACGGTGCGGTTCCCCGTTGTCGGGGCCTTTGCCAATTACGGCACAAGGTTTTTGGATCCAAGTATAAGTTTTGTTGTTTCGACCATATACGTGCTACAGTGGTTTTTTGTATTACCCTTAGAAATCATTGCGGCGGCAATGACCGTAACGTACTGGAACTCGTCTATTGACCCCGTAATTTGGGTAGCCATCTTTTATGCTGTTATTGTTTCCATAAATTTGTTTGGTGTACGAGGTTTTGGGGAAGCGGAATTTGCATTTTCCACCATAAAAGCAATAACAGTTTGCGGATTCATTATATTGTGCGTTGTCCTCATTTGCGGTGGAGGTCCCGACCACGAGTTCATTGGCGCCAAATACTGGCACGACCCTGGTTGTTTGGCCAATGGGTTCCCGGGCGTTCTATCTGTTCTTGTTGTTGCTTCGTATTCTCTCGGTGGTATAGAAATGACGTGCCTGGCATCAGGTGAAACGGACCCCAAAGGCTTACCAAGTGCTATCAAGCAAGTGTTTTGGAGGATCTTATTTTTCTTTTTGATATCACTGACCCTGGTAGGATTCCTGGTTCCATATACAAACCAAAACTTACTGGGTGGTTCATCTGTGGACAACTCACCTTTTGTCATTGCCATAAAATTGCATCACATTAAAGCCTTGCCCTCCATCGTCAATGCGGTCATCCTTATCAGTGTTTTGAGTGTAGGTAACTCCTGCATCTTCGCTTCAAGTAGAACGTTGTGTTCGATGGCCCACCAAGGCCTTATTCCATGGTGGTTTGGTTATATCGACCGTGCTGGTAGGCCGCTGGTTGGCATTATGGCAAATTCACTATTTGGATTACTAGCATTTCTGGTCAAATCTGGCTCGATGTCTGAAGTTTTCAATTGGTTAATGGCCATTGCCGGCCTGGCCACGTGCATTGTCTGGTTGAGCATCAACCTGTCACATATCAGATTTAGACTGGCGATGAAGGCTCAAGGGAAGTCTCTGGATGAATTAGAATTTGTTAGTGCTGTCGGGATTTGGGGATCAGCGTATTCCGCTTTAATCAACTGTCTAATCTTGATAGCTCAATTCTATTGTTCACTATGGCCCATTGGTGGCTGGACCAGCGGCAAAGAAAGGGCTAAAATATTTTTTCAAAATTATCTGTGTGCCTTAATCATGTTATTTATATTCATCGTCCACAAAATTTATTACAAGTGTCAAACAGGCAAATGGTGGGGGGTTAAGGCGTTAAAGGACATAGATTTGGAAACCGATCGTAAAGATATCGACATCGAAATAGTCAAGCAAGAAATTGCCGAAAAGAAAATGTACCTAGATTCCCGTCCATGGTACGTGAGACAGTTCCATTTCTGGTGTTAA","protein_sequence":"MTEDFISSVKRSNEELKERKSNFGFVEYKSKQLTSSSSHNSNSSHHDDDNQHGKRNIFQRCVDSFKSPLDGSFDTSNLKRTLKPRHLIMIAIGGSIGTGLFVGSGKAIAEGGPLGVVIGWAIAGSQIIGTIHGLGEITVRFPVVGAFANYGTRFLDPSISFVVSTIYVLQWFFVLPLEIIAAAMTVQYWNSSIDPVIWVAIFYAVIVSINLFGVRGFGEAEFAFSTIKAITVCGFIILCVVLICGGGPDHEFIGAKYWHDPGCLANGFPGVLSVLVVASYSLGGIEMTCLASGETDPKGLPSAIKQVFWRILFFFLISLTLVGFLVPYTNQNLLGGSSVDNSPFVIAIKLHHIKALPSIVNAVILISVLSVGNSCIFASSRTLCSMAHQGLIPWWFGYIDRAGRPLVGIMANSLFGLLAFLVKSGSMSEVFNWLMAIAGLATCIVWLSINLSHIRFRLAMKAQGKSLDELEFVSAVGIWGSAYSALINCLILIAQFYCSLWPIGGWTSGKERAKIFFQNYLCALIMLFIFIVHKIYYKCQTGKWWGVKALKDIDLETDRKDIDIEIVKQEIAEKKMYLDSRPWYVRQFHFWC"},{"created_at":"2011-05-24T21:03:21.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Leu/Val/Ile amino-acid permease","uniprot_id":"P38084","uniprot_name":"BAP2_YEAST","enzyme":false,"transporter":true,"gene_name":"BAP2","num_residues":609,"molecular_weight":"67669.60156","theoretical_pi":"8.22","general_function":"Involved in transport","specific_function":"Permease for leucine, valine and isoleucine. Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan","reactions":[],"signal_regions":"None","transmembrane_regions":"100-120;124-144;174-194;211-231;236-256;290-310;329-349;375-395;428-448;452-472;501-521;537-557","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z35937","genbank_protein_id":"536316","gene_card_id":"BAP2","chromosome_location":"chromosome 2","locus":"YBR068C","synonyms":["Branched-chain amino-acid permease 2"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGCTATCTTCAGAAGATTTTGGATCTTCTGGGAAAAAGGAAACTTCTCCTGATTCGATATCGATACGTTCCTTTAGTGCCGGGAATAATTTCCAATCATCATCAAGTGAGAAAACTTATTCTAAGCAAAAATCCGGGAGTGACAAACTTATACATAGATTTGCGGATTCATTCAAAAGAGCCGAGGGTAGCACTACAAGAACTAAGCAAATAAATGAAAATACGTCTGATTTAGAGGATGGCGTTGAGTCTATCACGTCGGATTCCAAGTTGAAAAAGTCCATGAAGTCGCGCCATGTTGTCATGATGTCTTTAGGGACAGGTATTGGGACTGGTCTTTTGGTAGCTAATGCAAAAGGTCTACATTACGGTGGTCCTGCTGCGCTAATAATTGGTTACATCTTGGTTTCTTTCGAGACGTACTTCATGATCCAAGCTGCAGGTGAGATGGCGGTAACCTATCCGACTTTACCAGCAAATTTCAACGCATACTCCTCCATATTCATTTCCAAATCATTTGGATTCGCCACAGTATGGCTTTACTGTTTCCAATGGCTAACGGTTTTGCCTTTAGAGTTAATAACCGCGTCTATGACTATTCAATTTGGGAATGATAAAATAAATCCGGACATTTATATTCTTATTTTCTATGTTTTCTTAGTATTCATTCATTTCTTCGGTGTAAAAGCCTATGGTGAAACGGAATTCATCTTCAATTGCTGTAAAATTTTAATGATTGCAGGTTTCATTATTCTTTCTATTGTTATCAACTGTGGTGGGGCCGGAAATGACGGTTATATCGGGGCCACTTATTGGCATAATCCAGGTGCTTTTGCAGGTGACACATCGATTGGTAGGTTCAAAAACGTTTGCTATATTTTAGTTACTGCTTACTTCTCCTTTGGTGGTATGGAATTATTTGCACTAAGTGTTCAGGAACAGTCTAACCCTAGAAAATCTACTCCGGTGGCAGCCAAGAGAAGCATTTATCGTATCGTTGTGATTTATCTTTTGACTATGATCCTCATTGGATTCAATGTTCCATATAATGATGACCAACTAATGGGCGCAGGCGGATCCGCTACACATGCATCTCCCTATGTCTTAGCCGCTTCTATTCACGGTGTGAAAATTGTTCCACATATTATCAACGCTGTTATTTTGATTTCTGTGGTTTCAGTGGCAAATTCCTCTTTGTATGCTGGTCCAAGACTGATTTGCTCTTTGGCCCAACAAGGCTACGCACCCAAGTTTTTAGATTACGTTGACAGAGAGGGCAGGCCCTTGAGAGCTCTTATTGTGTGTTGCGTTTTCGGCGTCATTGCTTTTGTTGCAGCTTCATCAAAGGAAGAGATCGTGTTTACATGGTTAGCAGCTATCGCAGGCTTGAGTGAATTATTCACATGGACTTCCATAATGTTGTCCCATCTGCGATTCAGACAAGCAATGAAAGTACAGGGAAGGTCTCTAGACGAGTTGGGATACAAGGCCACAACAGGGATTTGGGGTTCCATATACGGTGTCTTTTTTAATATTTTAGTCTTTGTTGCCCAATTTTGGGTAGCATTGGCCCCCTTAGGTAATGGGGGCAAATGCGATGCGGAATCCTTCTTTCAAAATTATTTAGCTTTTCCAATATGGTTGGCCTTTTACTTCGGATATATGGTTTACAACCGAGATTTTACGCTATTAAATCCCCTCGACAAGATTGACCTTGACTTCCACAGACGCATTTATGATCCAGAGCTAATGAGACAAGAGGACGAAGAAAATAAAGAAAAACTAAGGAATATGTCTTTGATGAGAAAAGCTTATCATTTCTGGTGTTAA","protein_sequence":"MLSSEDFGSSGKKETSPDSISIRSFSAGNNFQSSSSEKTYSKQKSGSDKLIHRFADSFKRAEGSTTRTKQINENTSDLEDGVESITSDSKLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLHYGGPAALIIGYILVSFETYFMIQAAGEMAVTYPTLPANFNAYSSIFISKSFGFATVWLYCFQWLTVLPLELITASMTIQFGNDKINPDIYILIFYVFLVFIHFFGVKAYGETEFIFNCCKILMIAGFIILSIVINCGGAGNDGYIGATYWHNPGAFAGDTSIGRFKNVCYILVTAYFSFGGMELFALSVQEQSNPRKSTPVAAKRSIYRIVVIYLLTMILIGFNVPYNDDQLMGAGGSATHASPYVLAASIHGVKIVPHIINAVILISVVSVANSSLYAGPRLICSLAQQGYAPKFLDYVDREGRPLRALIVCCVFGVIAFVAASSKEEIVFTWLAAIAGLSELFTWTSIMLSHLRFRQAMKVQGRSLDELGYKATTGIWGSIYGVFFNILVFVAQFWVALAPLGNGGKCDAESFFQNYLAFPIWLAFYFGYMVYNRDFTLLNPLDKIDLDFHRRIYDPELMRQEDEENKEKLRNMSLMRKAYHFWC"},{"created_at":"2011-05-24T21:03:55.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Valine/tyrosine/tryptophan amino-acid permease 1","uniprot_id":"P38085","uniprot_name":"TAT1_YEAST","enzyme":false,"transporter":true,"gene_name":"TAT1","num_residues":619,"molecular_weight":"68756.89844","theoretical_pi":"7.8","general_function":"Involved in transport","specific_function":"High-affinity transport of valine and tyrosine. Low- affinity transport of tryptophan. Can also transport L-cysteine","reactions":[],"signal_regions":"None","transmembrane_regions":"100-120;123-143;173-193;205-225;234-254;282-302;321-341;369-389;423-443;447-467;500-520;530-550","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"U10503","genbank_protein_id":"558077","gene_card_id":"TAT1","chromosome_location":"chromosome 2","locus":"YBR069C","synonyms":["Tyrosine and tryptophan amino acid transporter 1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGACGATAGTGTCAGTTTCATTGCCAAAGAGGCCAGTCCAGCACAATATTCGCACAGTTTGCATGAAAGAACACACAGTGAAAAACAAAAGAGAGACTTTACAATAACAGAAAAACAAGATGAGGTATCTGGACAAACAGCGGAGCCTCGAAGGACGGACAGCAAATCCATATTACAGAGGAAATGCAAAGAATTCTTCGACTCTTTTAAAAGGCAGCTGCCACCAGACCGTAATTCCGAACTAGAGTCCCAAGAAAAAAACAACCTGACAAAGTCGATCAAATCTCGTCACTTAGTCATGATCAGTCTCGGTACCGGTATAGGTACTGGTTTACTGGTCGGTAATGGTCAGGTGCTGGGAACAGCTGGTCCTGCCGGGTTAGTCCTTGGTTACGGAATAGCATCGATCATGCTTTACTGTATCATCCAAGCGGCAGGCGAGTTAGGTCTCTGTTATGCAGGACTAACCGGCAATTACACCAGATATCCTTCTATTTTAGTCGACCCTTCGTTGGGTTTTGCAGTTTCTGTGGTTTACACCATTCAATGGCTAACTGTTCTGCCCTTACAATTGGTCACTGCGGCAATGACAGTTAAGTACTGGACGAGTGTAAATGCAGACATCTTTGTTGCCGTGGTTTTCGTTTTTGTAATTATCATTAATCTATTTGGGTCCAGAGGCTATGCTGAAGCCGAGTTCATTTTCAATTCCTGTAAGATATTGATGGTAATCGGATTCGTCATTCTGGCGATTATCATCAATTGTGGGGGTGCAGGTGACAGAAGATACATCGGTGCTGAGTACTGGCACAATCCTGGTCCATTTGCCCACGGTTTCAAAGGTGTATGTACGGTTTTCTGTTATGCTGCATTCAGCTACGGTGGAATTGAAGTTCTACTTCTATCTGCCGCTGAGCAGGAAAACCCAACAAAATCTATTCCCAATGCCTGCAAAAAAGTGGTATACCGTATTCTGCTGATTTACATGCTCACCACCATTTTGGTTTGCTTTCTTGTTCCATACAACAGTGACGAATTATTAGGGTCTAGTGACTCCTCTGGATCCCATGCCTCCCCATTTGTCATTGCTGTTGCATCACATGGTGTCAAAGTTGTGCCTCACTTTATAAATGCTGTTATTTTGATTTCTGTCATTTCTGTTGCAAACTCTTCGTTATATTCTGGGCCAAGATTGTTATTATCATTGGCAGAACAAGGCGTCTTACCTAAATGCTTAGCATATGTTGATAGAAACGGCAGGCCTTTACTTTGTTTTTTTGTTTCCCTTGTCTTTGGATGCATTGGGTTTGTAGCCACTAGTGACGCTGAAGAACAGGTTTTCACCTGGTTATTGGCAATTTCTAGTCTTTCGCAATTATTTATCTGGATGTCAATGTCCTTGTCACATATAAGATTTAGAGATGCCATGGCAAAGCAAGGTCGTTCGATGAACGAAGTTGGATACAAAGCACAAACTGGCTATTGGGGTTCATGGCTTGCAGTTTTAATTGCAATCTTCTTCCTTGTGTGCCAGTTCTGGGTAGCCATCGCACCTGTTAATGAACATGGAAAACTTAACGTCAAAGTGTTTTTCCAAAATTATTTGGCAATGCCCATCGTTTTGTTTGCCTATTTTGGTCACAAGATATACTTCAAATCATGGAGCTTTTGGATTCCAGCCGAAAAAATTGATTTGGACTCACATAGAAACATATTTGTGTCTCCATCGCTTACAGAGATCGACAAAGTTGACGATAACGATGATCTTAAAGAGTATGAAAATTCAGAATCGTCGGAAAATCCAAACAGTTCGCGTTCAAGAAAGTTTTTTAAGAGGATGACCAATTTCTGGTGCTAA","protein_sequence":"MDDSVSFIAKEASPAQYSHSLHERTHSEKQKRDFTITEKQDEVSGQTAEPRRTDSKSILQRKCKEFFDSFKRQLPPDRNSELESQEKNNLTKSIKSRHLVMISLGTGIGTGLLVGNGQVLGTAGPAGLVLGYGIASIMLYCIIQAAGELGLCYAGLTGNYTRYPSILVDPSLGFAVSVVYTIQWLTVLPLQLVTAAMTVKYWTSVNADIFVAVVFVFVIIINLFGSRGYAEAEFIFNSCKILMVIGFVILAIIINCGGAGDRRYIGAEYWHNPGPFAHGFKGVCTVFCYAAFSYGGIEVLLLSAAEQENPTKSIPNACKKVVYRILLIYMLTTILVCFLVPYNSDELLGSSDSSGSHASPFVIAVASHGVKVVPHFINAVILISVISVANSSLYSGPRLLLSLAEQGVLPKCLAYVDRNGRPLLCFFVSLVFGCIGFVATSDAEEQVFTWLLAISSLSQLFIWMSMSLSHIRFRDAMAKQGRSMNEVGYKAQTGYWGSWLAVLIAIFFLVCQFWVAIAPVNEHGKLNVKVFFQNYLAMPIVLFAYFGHKIYFKSWSFWIPAEKIDLDSHRNIFVSPSLTEIDKVDDNDDLKEYENSESSENPNSSRSRKFFKRMTNFWC"},{"created_at":"2011-05-24T21:05:56.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Valine amino-acid permease","uniprot_id":"P41815","uniprot_name":"BAP3_YEAST","enzyme":false,"transporter":true,"gene_name":"BAP3","num_residues":604,"molecular_weight":"67364.39844","theoretical_pi":"8.28","general_function":"Involved in transport","specific_function":"Involved in transport of isoleucine, leucine, valine, cysteine, methionine, phenylalanine, tyrosine and tryptophan","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;120-140;170-190;207-227;239-259;285-305;324-344;378-398;424-444;450-470;503-523;532-552","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z49209","genbank_protein_id":"798899","gene_card_id":"BAP3","chromosome_location":"chromosome 4","locus":"YDR046C","synonyms":["Branched-chain amino-acid permease 3"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCAGATCCTATAGTAACGTCTTCCAAAATGGAAAAAAGTGCAGAGTTTGAAGTAACAGACTCTGCTTTATATAATAACTTCAATACATCAACAACAGCTTCACTAACTCCGGAGATTAAGGAACATTCTGAGGAATCTCGCAATGGGTTAGTTCACAGATTCGTCGACTCATTCAGAAGAGCCGAAAGCCAACGTTTAGAAGAAGACAATGACTTGGAGGATGGTACCAAATCGATGAAATCTAATAACCACTTAAAAAAGTCAATGAAATCTAGACATGTTGTAATGATGTCTTTAGGTACAGGGATAGGAACAGGTCTTCTAGTTGCCAACGCCAAAGGTTTGAGTCTTGCAGGCCCGGGGTCTTTAGTCATCGGTTACGTTATGGTGTCCTTCGTCACGTATTTTATGGTCCAAGCGGCTGGTGAGATGGGTGTCACTTATCCGACGCTTCCAGGTAACTTCAATGCATACAATTCAATCTTTATTTCAAAGTCGTTTGGGTTCGCGACCACTTGGTTATTTTGCATTCAGTGGTTAACTGTGCTACCGTTGGAATTGATTACTTCTTCCATGACCGTCAAGTACTGGAATGACACAATTAATGCTGATGTATTCATTGTCATTTTCTATGTGTTTTTATTGTTTATCCACTTTTTTGGTGTTAAGGCATACGGTGAAACGGAATTTATCTTCAATTCCTGTAAGATATTGATGGTTGCAGGATTCATTATTTTATCAGTCGTCATCAATTGTGGGGGAGCCGGTGTGGACGGCTATATTGGCGGCAAATATTGGCGCGACCCTGGTTCATTTGCAGAAGGCAGCGGTGCCACTCGTTTCAAAGGGATATGTTATATTCTAGTATCTGCATATTTCTCCTTCGGTGGTATTGAATTATTTGTTCTTTCCATCAATGAGCAGTCTAACCCTAGAAAATCCACTCCTGTAGCCGCGAAGAGAAGTGTATATCGTATTTTGATCATTTATTTGCTGACAATGATTCTAATTGGGTTCAATGTTCCTCACAATAACGATCAATTGATGGGTTCCGGTGGCTCCGCAACGCACGCTTCACCATATGTCTTGGCAGCCTCTATTCACAAGGTTAGGGTCATCCCCCATATCATTAATGCTGTTATTTTGATATCAGTCATCTCTGTTGCGAACTCTGCCCTTTATGCCGCACCGAGATTAATGTGTTCCTTGGCTCAACAGGGCTATGCTCCAAAATTTTTGAACTATATTGATAGGGAGGGAAGACCTTTAAGGGCCTTGGTAGTGTGCTCTCTTGTTGGTGTCGTTGGCTTCGTCGCCTGTTCTCCACAGGAAGAGCAAGCATTTACATGGTTGGCAGCCATTGCAGGTTTGAGTGAACTTTTCACATGGTCAGGCATTATGCTTTCACACATTCGATTCAGAAAAGCGATGAAAGTCCAAGGAAGATCACTTGATGAAGTCGGCTATAAGGCCAATACCGGTATATGGGGTTCATACTATGGGGTTTTTTTCAATATGCTTGTCTTTATGGCCCAATTTTGGGTCGCACTGTCTCCAATAGGAAATGGCGGAAAGTGTGATGCTCAGGCATTCTTCGAGAGTTATCTGGCTGCCCCGCTATGGATATTCATGTATGTTGGATACATGGTTTACAAAAGAGATTTTACCTTTTTAAACCCACTGGACAAGATCGACTTGGACTTTCATAGAAGAGTTTACGACCCTGAAATAATGAGGCAGGAGGACGAAGAAAATAAAGAAAGGTTAAAGAACTCTTCAATATTCGTCAGAGTCTACAAATTTTGGTGTTAG","protein_sequence":"MSDPIVTSSKMEKSAEFEVTDSALYNNFNTSTTASLTPEIKEHSEESRNGLVHRFVDSFRRAESQRLEEDNDLEDGTKSMKSNNHLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLSLAGPGSLVIGYVMVSFVTYFMVQAAGEMGVTYPTLPGNFNAYNSIFISKSFGFATTWLFCIQWLTVLPLELITSSMTVKYWNDTINADVFIVIFYVFLLFIHFFGVKAYGETEFIFNSCKILMVAGFIILSVVINCGGAGVDGYIGGKYWRDPGSFAEGSGATRFKGICYILVSAYFSFGGIELFVLSINEQSNPRKSTPVAAKRSVYRILIIYLLTMILIGFNVPHNNDQLMGSGGSATHASPYVLAASIHKVRVIPHIINAVILISVISVANSALYAAPRLMCSLAQQGYAPKFLNYIDREGRPLRALVVCSLVGVVGFVACSPQEEQAFTWLAAIAGLSELFTWSGIMLSHIRFRKAMKVQGRSLDEVGYKANTGIWGSYYGVFFNMLVFMAQFWVALSPIGNGGKCDAQAFFESYLAAPLWIFMYVGYMVYKRDFTFLNPLDKIDLDFHRRVYDPEIMRQEDEENKERLKNSSIFVRVYKFWC"},{"created_at":"2011-05-26T18:28:20.000Z","updated_at":"2011-05-27T15:01:04.000Z","name":"Tryptophanyl-tRNA 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ligase","TrpRS"],"enzyme_classes":["6.1.1.2"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" tryptophan-tRNA ligase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" nucleotide 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aminoacylation"}],"pfams":[{"name":"tRNA-synt_1b","identifier":"PF00579"}],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGTCGAATAAGCAGGCGGTTCTGAAGTTAATCAGTAAAAGGTGGATAAGCACAGTGCAACGTGCCGATTTTAAGCTGAATTCCGAAGCGCTTCATAGTAATGCTACGGTATTTAGTATGATTCAGCCAACTGGGTGTTTCCACCTTGGTAATTATCTAGGTGCTACACGTGTTTGGACAGACTTATGTGAATTAAAACAACCTGGCCAGGAATTGATATTTGGAGTTGCTGATTTACACGCTATCACTGTTCCAAAGCCAGATGGAGAAATGTTTAGAAAATTTCGCCATGAGGCAGTAGCAAGTATACTGGCTGTCGGTGTAGATCCAGAAAAGGCTTCGGTGATCTACCAATCCGCCATCCCTCAACACAGTGAATTACACTGGTTGCTTTCTACTCTTGCCTCGATGGGATTACTTAACCGCATGACGCAATGGAAATCAAAATCGAATATCAAACAATCAACTAATGGGGATTATCTGGTTAACGATTCTGACGTGGGAAAAGTTAGACTGGGCTTATTTTCGTATCCTGTTTTACAGGCAGCGGATATTCTACTTTATAAATCTACACACGTTCCTGTTGGCGATGATCAATCGCAGCATTTGGAACTAACAAGACACCTTGCTGAAAAGTTTAACAAAATGTACAAGAAAAATTTTTTTCCTAAACCTGTAACTATGTTGGCACAAACGAAAAAAGTTTTGAGCTTAAGCACGCCTGAAAAGAAAATGTCCAAGAGTGATCCGAATCACGACTCTGTAATTTTTTTGAATGATGAGCCTAAGGCAATTCAGAAAAAGATTAGAAAAGCTTTAACAGATTCCATTTCTGATAGGTTCTACTACGACCCTGTAGAAAGACCAGGCGTATCGAATTTAATTAACATTGTCAGTGGCATTCAAAGAAAATCGATTGAAGATGTCGTAGAAGATGTATCTCGTTTCAATAACTATAGGGATTTCAAAGATTATGTTTCAGAAGTGATAATTGAGGAATTGAAAGGCCCAAGAACAGAATTTGAGAAATATATCAACGAACCGACCTATTTGCATAGTGTCGTTGAATCTGGCATGCGCAAAGCGAGAGAAAAAGCAGCAAAAAACCTGGCCGACATTCATAAAATAATGGGCTTCTGA","protein_sequence":"MSNKQAVLKLISKRWISTVQRADFKLNSEALHSNATVFSMIQPTGCFHLGNYLGATRVWTDLCELKQPGQELIFGVADLHAITVPKPDGEMFRKFRHEAVASILAVGVDPEKASVIYQSAIPQHSELHWLLSTLASMGLLNRMTQWKSKSNIKQSTNGDYLVNDSDVGKVRLGLFSYPVLQAADILLYKSTHVPVGDDQSQHLELTRHLAEKFNKMYKKNFFPKPVTMLAQTKKVLSLSTPEKKMSKSDPNHDSVIFLNDEPKAIQKKIRKALTDSISDRFYYDPVERPGVSNLINIVSGIQRKSIEDVVEDVSRFNNYRDFKDYVSEVIIEELKGPRTEFEKYINEPTYLHSVVESGMRKAREKAAKNLADIHKIMGF"},{"created_at":"2011-05-26T18:49:11.000Z","updated_at":"2011-05-27T15:01:05.000Z","name":"Tryptophanyl-tRNA 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ligase","TrpRS"],"enzyme_classes":["6.1.1.2"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" tryptophan-tRNA ligase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" tryptophanyl-tRNA aminoacylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"}],"pfams":[{"name":"tRNA-synt_1b","identifier":"PF00579"}],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGAGCAACGACGAAACTGTAGAGAAAGTCACCCAACAAGTGTCGGAACTAAAAAGCACAGATGTTAAAGAGCAAGTAGTTACACCTTGGGATGTGGAAGGTGGGGTTGATGAACAAGGTAGAGCCCAAAATATTGATTACGACAAATTGATCAAACAATTCGGTACTAAGCCGGTCAACGAAGAAACCCTGAAGAGATTCAAGCAAGTGACGGGTCGTGAACCACATCATTTTTTGCGTAAGGGATTGTTTTTCAGTGAGCGTGACTTCACTAAAATATTAGACCTTTACGAACAAGGCAAACCATTTTTCCTATACACTGGTAGAGGTCCTTCGAGCGATTCTATGCACTTGGGTCATATGATCCCTTTTGTCTTCACCAAATGGTTACAGGAAGTGTTTGACGTACCATTAGTCATAGAGTTGACAGATGACGAAAAATTTTTATTCAAACACAAGTTGACCATCAATGACGTTAAGAATTTTGCCCGTGAAAATGCCAAGGATATCATTGCTGTTGGCTTTGATCCAAAGAACACCTTTATCTTTTCTGATTTGCAATACATGGGTGGTGCATTTTACGAAACTGTAGTAAGAGTTTCCAGACAAATTACAGGATCCACTGCAAAGGCTGTTTTCGGGTTTAATGACTCCGACTGTATTGGTAAGTTCCATTTTGCCTCCATTCAAATTGCTACCGCATTCCCAAGCTCATTTCCTAATGTGTTAGGCTTGCCTGATAAGACACCATGTTTGATTCCATGTGCAATTGACCAAGATCCATATTTCAGAGTTTGTAGGGATGTCGCGGATAAATTGAAGTACTCCAAACCTGCTTTGCTTCATTCCAGATTCTTTCCAGCTTTGCAAGGTTCCACGACCAAAATGTCAGCCTCTGATGATACCACTGCCATTTTCATGACCGATACACCAAAGCAAATTCAAAAGAAAATTAACAAGTACGCATTCAGCGGTGGTCAAGTGTCCGCCGACCTACATAGAGAATTAGGTGGTAATCCCGATGTCGATGTTGCATACCAATACTTGTCATTTTTCAAGGATGACGATGTTTTCTTGAAGGAATGCTATGACAAATATAAGTCCGGTGAATTACTATCAGGTGAAATGAAGAAACTGTGTATCGAGACTCTGCAAGAATTCGTTAAGGCGTTCCAGGAACGCAGAGCTCAGGTGGACGAAGAGACCTTGGACAAATTCATGGTCCCACATAAGTTGGTTTGGGGCGAAAAGGAAAGACTTGTCGCACCTAAGCCAAAAACTAAGCAAGAAAAGAAGTAA","protein_sequence":"MSNDETVEKVTQQVSELKSTDVKEQVVTPWDVEGGVDEQGRAQNIDYDKLIKQFGTKPVNEETLKRFKQVTGREPHHFLRKGLFFSERDFTKILDLYEQGKPFFLYTGRGPSSDSMHLGHMIPFVFTKWLQEVFDVPLVIELTDDEKFLFKHKLTINDVKNFARENAKDIIAVGFDPKNTFIFSDLQYMGGAFYETVVRVSRQITGSTAKAVFGFNDSDCIGKFHFASIQIATAFPSSFPNVLGLPDKTPCLIPCAIDQDPYFRVCRDVADKLKYSKPALLHSRFFPALQGSTTKMSASDDTTAIFMTDTPKQIQKKINKYAFSGGQVSADLHRELGGNPDVDVAYQYLSFFKDDDVFLKECYDKYKSGELLSGEMKKLCIETLQEFVKAFQERRAQVDEETLDKFMVPHKLVWGEKERLVAPKPKTKQEKK"},{"created_at":"2011-05-27T02:01:15.000Z","updated_at":"2011-05-27T15:01:16.000Z","name":"Tryptophan synthase","uniprot_id":"P00931","uniprot_name":"TRP_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP5","num_residues":707,"molecular_weight":"76625.5","theoretical_pi":"6.47","general_function":"Involved in catalytic activity","specific_function":"L-serine + 1-C-(indol-3-yl)glycerol 3- phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O","reactions":[{"id":2023,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2656,"direction":"\u003e","locations":null,"altext":"L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":14106,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006531","source":"Smpdb"},{"id":14107,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006532","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"V01342","genbank_protein_id":"4674","gene_card_id":"TRP5","chromosome_location":"chromosome 7","locus":"YGL026C","synonyms":[],"enzyme_classes":["4.2.1.20"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" hydro-lyase activity"},{"category":"Function","description":" tryptophan synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"}],"pfams":[{"name":"PALP","identifier":"PF00291"},{"name":"Trp_syntA","identifier":"PF00290"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGTCAGAACAACTCAGACAAACATTTGCTAACGCTAAAAAAGAAAACAGGAACGCCTTGGTCACATTTATGACCGCAGGTTACCCAACAGTCAAAGACACTGTCCCTATTCTCAAGGGTTTCCAGGATGGTGGTGTAGATATCATCGAATTGGGTATGCCCTTCTCTGATCCAATTGCAGATGGTCCTACAATTCAATTATCTAATACTGTGGCTTTGCAAAACGGTGTTACCTTGCCTCAAACTCTAGAAATGGTCTCCCAAGCTAGAAATGAAGGTGTTACCGTACCCATAATCCTAATGGGTTACTATAACCCTATTCTAAACTACGGTGAAGAAAGATTTATTCAGGACGCTGCCAAGGCTGGTGCTAATGGTTTTATCATCGTCGATTTGCCACCAGAGGAGGCGTTGAAGGTCAGAAACTACATCAATGATAATGGTTTGAGCCTGATCCCACTAGTGGCTCCTTCTACCACCGACGAAAGATTGGAATTACTATCACATATTGCCGATTCGTTTGTCTACGTTGTGTCTAGAATGGGTACTACTGGTGTTCAAAGTTCTGTGGCCAGTGATTTGGATGAACTCATCTCTAGAGTCAGAAAGTACACCAAGGATACTCCTTTGGCCGTTGGGTTTGGTGTCTCTACCAGAGAACATTTCCAATCAGTTGGTAGTGTTGCTGACGGTGTAGTGATTGGTTCCAAAATCGTCACATTATGTGGAGATGCTCCAGAGGGCAAAAGGTACGACGTTGCTAAGGAATATGTACAGGGAATTCTAAATGGTGCTAAGCATAAGGTTCTGTCCAAGGACGAATTCTTTGCCTTTCAAAAAGAGTCCTTGAAGTCCGCAAACGTTAAGAAGGAAATACTGGACGAATTTGATGAAAATCACAAGCACCCAATTAGATTTGGGGACTTTGGTGGTCAGTATGTCCCAGAAGCTCTTCATGCATGTCTAAGAGAGTTGGAAAAGGGTTTTGATGAAGCTGTCGCCGATCCCACATTCTGGGAAGACTTCAAATCCTTGTATTCTTATATTGGCCGTCCTTCTTCACTACACAAAGCTGAGAGATTAACTGAGCATTGTCAAGGTGCTCAAATCTGGTTGAAGAGAGAAGATCTTAACCACACGGGATCTCACAAGATCAACAATGCTTTAGCACAAGTTCTTCTAGCTAAAAGATTAGGCAAGAAGAACGTTATTGCTGAAACCGGTGCTGGTCAACACGGTGTTGCCACTGCCACTGCATGTGCTAAATTTGGCTTAACCTGTACTGTGTTCATGGGTGCAGAAGATGTTCGTCGCCAAGCTTTAAACGTCTTCAGAATGAGAATTCTCGGTGCTAAAGTAATTGCTGTTACTAATGGTACAAAGACTCTAAGAGACGCTACTTCAGAGGCATTCAGATTTTGGGTTACTAACTTGAAAACTACTTACTACGTCGTCGGTTCTGCCATTGGTCCTCACCCATATCCAACTTTGGTTAGAACTTTCCAAAGTGTCATTGGTAAAGAAACCAAGGAACAGTTTGCTGCCATGAACAATGGTAAATTACCTGACGCAGTTGTTGCATGTGTTGGGGGTGGTTCCAACTCTACAGGTATGTTTTCACCATTCGAGCATGATACTTCCGTTAAGTTATTGGGTGTGGAAGCCGGTGGTGATGGTGTAGATACAAAGTTCCACTCTGCTACTCTAACTGCCGGTAGACCTGGTGTCTTCCATGGTGTCAAGACTTATGTCTTGCAAGATAGTGATGGTCAAGTCCATGATACTCATTCTGTTTCTGCTGGGTTAGACTACCCAGGTGTCGGTCCAGAATTGGCATATTGGAAATCTACTGGCCGTGCTCAATTCATTGCAGCTACTGACGCTCAGGCTCTGCTTGGCTTTAAATTATTATCTCAATTAGAAGGTATTATTCCCGCTTTGGAATCTTCTCATGCTGTTTATGGCGCTTGCGAATTGGCTAAGACGATGAAGCCTGATCAACATTTGGTTATCAATATTTCTGGTAGAGGTGATAAAGATGTCCAAAGTGTCGCTGAAGTCTTGCCGAAATTAGGTCCAAAGATAGGTTGGGATTTGAGATTCGAAGAAGACCCATCTGCCTAA","protein_sequence":"MSEQLRQTFANAKKENRNALVTFMTAGYPTVKDTVPILKGFQDGGVDIIELGMPFSDPIADGPTIQLSNTVALQNGVTLPQTLEMVSQARNEGVTVPIILMGYYNPILNYGEERFIQDAAKAGANGFIIVDLPPEEALKVRNYINDNGLSLIPLVAPSTTDERLELLSHIADSFVYVVSRMGTTGVQSSVASDLDELISRVRKYTKDTPLAVGFGVSTREHFQSVGSVADGVVIGSKIVTLCGDAPEGKRYDVAKEYVQGILNGAKHKVLSKDEFFAFQKESLKSANVKKEILDEFDENHKHPIRFGDFGGQYVPEALHACLRELEKGFDEAVADPTFWEDFKSLYSYIGRPSSLHKAERLTEHCQGAQIWLKREDLNHTGSHKINNALAQVLLAKRLGKKNVIAETGAGQHGVATATACAKFGLTCTVFMGAEDVRRQALNVFRMRILGAKVIAVTNGTKTLRDATSEAFRFWVTNLKTTYYVVGSAIGPHPYPTLVRTFQSVIGKETKEQFAAMNNGKLPDAVVACVGGGSNSTGMFSPFEHDTSVKLLGVEAGGDGVDTKFHSATLTAGRPGVFHGVKTYVLQDSDGQVHDTHSVSAGLDYPGVGPELAYWKSTGRAQFIAATDAQALLGFKLLSQLEGIIPALESSHAVYGACELAKTMKPDQHLVINISGRGDKDVQSVAEVLPKLGPKIGWDLRFEEDPSA"},{"created_at":"2011-05-27T02:15:50.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Aromatic amino acid aminotransferase 2","uniprot_id":"P38840","uniprot_name":"ARO9_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO9","num_residues":513,"molecular_weight":"58527.0","theoretical_pi":"5.16","general_function":"Involved in transferase activity, transferring nitrogenous groups","specific_function":"Has aromatic amino acid transaminase activity and kynurenine aminotransferase activity","reactions":[{"id":1839,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2024,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2027,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2667,"direction":"\u003e","locations":"Cytoplasm","altext":"An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3787,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006309","source":"Smpdb"},{"id":3788,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006518","source":"Smpdb"},{"id":3789,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006523","source":"Smpdb"},{"id":3790,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006536","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U10398","genbank_protein_id":"500670","gene_card_id":"ARO9","chromosome_location":"chromosome 8","locus":"YHR137W","synonyms":["Aromatic amino acid aminotransferase II","Aromatic amino acid-requiring protein 9"],"enzyme_classes":["2.6.1.57"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACTGCTGGTTCTGCCCCCCCTGTTGATTACACTTCCTTAAAGAAGAACTTCCAACCGTTTCTCTCCAGAAGAGTAGAAAATAGATCTCTGAAAAGCTTTTGGGATGCTTCTGATATCTCAGATGACGTCATTGAGCTAGCTGGTGGAATGCCAAACGAGAGATTTTTTCCTATCGAATCTATGGATTTGAAAATATCAAAAGTTCCTTTTAATGATAACCCAAAATGGCATAATTCGTTTACCACGGCGCATTTGGACTTGGGATCCCCCAGTGAGCTACCCATTGCACGTTCTTTCCAATATGCAGAAACCAAGGGTTTACCCCCTCTCTTACATTTTGTTAAAGATTTTGTGTCCAGAATTAATCGCCCAGCCTTTTCCGATGAGACGGAGTCTAACTGGGATGTCATCCTTTCTGGCGGGTCCAACGATTCAATGTTTAAGGTTTTTGAAACAATTTGCGACGAATCGACCACTGTGATGATTGAAGAGTTTACTTTCACCCCGGCTATGTCCAATGTGGAGGCTACAGGAGCAAAAGTCATCCCCATCAAGATGAACCTGACCTTCGACAGAGAGTCCCAGGGTATTGATGTCGAATATCTAACGCAGTTGCTCGATAATTGGTCAACTGGACCATACAAAGACTTAAACAAGCCAAGGGTCCTATATACCATTGCAACGGGCCAAAATCCTACCGGGATGTCTGTCCCCCAGTGGAAAAGAGAGAAAATTTACCAGTTGGCCCAAAGACACGATTTCCTCATTGTTGAAGATGATCCCTACGGTTATCTGTACTTTCCTTCCTATAATCCGCAAGAGCCATTAGAAAACCCTTACCATTCTAGCGACCTGACTACTGAACGGTATTTGAATGATTTTTTAATGAAATCATTCTTGACTTTGGATACAGATGCCCGTGTCATCCGTTTGGAGACTTTTTCTAAAATTTTTGCTCCTGGATTAAGGTTATCCTTCATCGTTGCTAATAAATTCCTTTTGCAAAAAATCTTGGATTTGGCCGACATTACTACAAGGGCCCCCAGTGGTACCTCACAAGCTATTGTTTATTCTACAATAAAGGCAATGGCTGAGTCCAACTTATCGTCCTCTCTTTCTATGAAAGAAGCAATGTTTGAGGGTTGGATAAGATGGATAATGCAGATTGCTTCTAAATACAATCATAGGAAAAATCTTACTTTGAAAGCCTTATACGAAACAGAATCTTACCAAGCTGGTCAGTTTACCGTTATGGAACCCTCCGCGGGTATGTTCATCATTATTAAAATCAATTGGGGGAATTTCGATAGACCTGACGATTTGCCGCAACAGATGGATATTTTAGATAAGTTCTTGCTGAAGAATGGTGTTAAAGTAGTGCTTGGTTATAAAATGGCTGTTTGCCCAAATTATTCAAAGCAGAATTCAGATTTTCTAAGACTCACCATCGCCTATGCAAGGGATGATGATCAGTTGATTGAAGCTTCCAAAAGAATCGGTAGTGGCATAAAAGAATTTTTTGACAACTATAAAAGTTGA","protein_sequence":"MTAGSAPPVDYTSLKKNFQPFLSRRVENRSLKSFWDASDISDDVIELAGGMPNERFFPIESMDLKISKVPFNDNPKWHNSFTTAHLDLGSPSELPIARSFQYAETKGLPPLLHFVKDFVSRINRPAFSDETESNWDVILSGGSNDSMFKVFETICDESTTVMIEEFTFTPAMSNVEATGAKVIPIKMNLTFDRESQGIDVEYLTQLLDNWSTGPYKDLNKPRVLYTIATGQNPTGMSVPQWKREKIYQLAQRHDFLIVEDDPYGYLYFPSYNPQEPLENPYHSSDLTTERYLNDFLMKSFLTLDTDARVIRLETFSKIFAPGLRLSFIVANKFLLQKILDLADITTRAPSGTSQAIVYSTIKAMAESNLSSSLSMKEAMFEGWIRWIMQIASKYNHRKNLTLKALYETESYQAGQFTVMEPSAGMFIIIKINWGNFDRPDDLPQQMDILDKFLLKNGVKVVLGYKMAVCPNYSKQNSDFLRLTIAYARDDDQLIEASKRIGSGIKEFFDNYKS"},{"created_at":"2011-05-27T02:16:21.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Aromatic amino acid aminotransferase 1","uniprot_id":"P53090","uniprot_name":"ARO8_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO8","num_residues":500,"molecular_weight":"56177.30078","theoretical_pi":"5.86","general_function":"Involved in transferase activity, transferring nitrogenous groups","specific_function":"Has aromatic amino acid transaminase activity. Also active with methionine, alpha-aminoadipate and leucine when phenylpyruvate is the amino acceptor","reactions":[{"id":1839,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2024,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2027,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2667,"direction":"\u003e","locations":"Cytoplasm","altext":"An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2668,"direction":"\u003e","locations":"Cytoplasm","altext":"L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate","export":false,"pw_reaction_id":null,"source":null},{"id":14093,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006519","source":"Smpdb"},{"id":14094,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006524","source":"Smpdb"},{"id":14095,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006535","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692962","genbank_protein_id":"51013375","gene_card_id":"ARO8","chromosome_location":"chromosome 7","locus":"YGL202W","synonyms":["Aromatic amino acid aminotransferase I","Aromatic amino acid-requiring protein 8"],"enzyme_classes":["2.6.1.57","2.6.1.39"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACTTTACCTGAATCAAAAGACTTTTCTTACTTGTTTTCGGATGAAACCAATGCTCGTAAACCATCCCCATTGAAAACCTGCATCCATCTTTTCCAAGATCCTAACATTATCTTTTTGGGTGGTGGCCTGCCATTAAAAGATTATTTCCCATGGGATAATCTATCTGTAGATTCACCCAAGCCTCCTTTTCCCCAGGGTATTGGAGCTCCAATTGACGAGCAGAATTGCATAAAATACACCGTCAACAAAGATTACGCTGATAAAAGTGCCAATCCTTCCAACGATATTCCTTTGTCAAGAGCTTTGCAATACGGGTTCAGTGCTGGTCAACCTGAACTATTAAACTTCATTAGAGATCATACCAAGATTATCCACGATTTGAAGTATAAGGACTGGGACGTTTTAGCCACTGCAGGTAACACAAATGCCTGGGAATCTACTTTAAGAGTCTTTTGTAACCGAGGTGATGTCATCTTAGTTGAGGCACATTCTTTTTCCTCTTCATTGGCTTCTGCAGAGGCTCAAGGTGTCATTACCTTCCCCGTGCCAATTGACGCTGATGGTATCATTCCTGAAAAATTAGCTAAAGTCATGGAAAACTGGACACCTGGTGCTCCTAAACCAAAGTTGTTATACACTATTCCAACGGGCCAAAATCCAACTGGTACTTCCATTGCAGACCATAGAAAGGAGGCAATTTACAAGATCGCTCAAAAGTACGACTTCCTAATTGTGGAAGATGAACCTTATTATTTCTTACAAATGAATCCCTACATCAAAGACTTGAAGGAAAGAGAGAAGGCACAAAGTTCTCCAAAGCAGGACCATGACGAATTTTTGAAGTCCTTGGCAAACACTTTCCTTTCCTTGGATACAGAAGGCCGTGTTATTAGAATGGATTCCTTTTCAAAAGTTTTGGCCCCAGGGACAAGATTGGGTTGGATTACTGGTTCATCCAAAATCTTGAAGCCTTACTTGAGTTTGCATGAAATGACGATTCAAGCCCCAGCAGGTTTTACACAAGTTTTGGTCAACGCTACGCTATCCAGGTGGGGTCAAAAGGGTTACTTGGACTGGTTGCTTGGCCTGCGTCATGAATACACTTTGAAACGTGACTGTGCCATCGATGCCCTTTACAAGTATCTACCACAATCTGATGCTTTCGTGATCAATCCTCCAATTGCAGGTATGTTTTTCACCGTGAACATTGACGCATCTGTCCACCCTGAGTTTAAAACAAAATACAACTCAGACCCTTACCAGCTAGAACAGAGTCTTTACCACAAAGTGGTTGAACGTGGTGTTTTAGTGGTTCCCGGTTCTTGGTTCAAGAGTGAGGGTGAGACGGAACCTCCTCAACCCGCTGAATCTAAAGAAGTCAGTAATCCAAACATAATTTTCTTCAGAGGTACCTATGCAGCTGTCTCTCCTGAGAAACTGACTGAAGGTCTGAAGAGATTAGGTGATACTTTATACGAAGAATTTGGTATTTCCAAATAG","protein_sequence":"MTLPESKDFSYLFSDETNARKPSPLKTCIHLFQDPNIIFLGGGLPLKDYFPWDNLSVDSPKPPFPQGIGAPIDEQNCIKYTVNKDYADKSANPSNDIPLSRALQYGFSAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNAWESTLRVFCNRGDVILVEAHSFSSSLASAEAQGVITFPVPIDADGIIPEKLAKVMENWTPGAPKPKLLYTIPTGQNPTGTSIADHRKEAIYKIAQKYDFLIVEDEPYYFLQMNPYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLDTEGRVIRMDSFSKVLAPGTRLGWITGSSKILKPYLSLHEMTIQAPAGFTQVLVNATLSRWGQKGYLDWLLGLRHEYTLKRDCAIDALYKYLPQSDAFVINPPIAGMFFTVNIDASVHPEFKTKYNSDPYQLEQSLYHKVVERGVLVVPGSWFKSEGETEPPQPAESKEVSNPNIIFFRGTYAAVSPEKLTEGLKRLGDTLYEEFGISK"},{"created_at":"2011-05-27T02:16:50.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Indoleamine 2,3-dioxygenase family protein","uniprot_id":"P47125","uniprot_name":"I23O_YEAST","enzyme":true,"transporter":false,"gene_name":"BNA2","num_residues":453,"molecular_weight":"50774.80078","theoretical_pi":"8.11","general_function":"Involved in heme binding","specific_function":"Required for biosynthesis of nicotinic acid","reactions":[{"id":1707,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":4189,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006489","source":"Smpdb"},{"id":4190,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006533","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"L47993","genbank_protein_id":"1019699","gene_card_id":"BNA2","chromosome_location":"chromosome 10","locus":"YJR078W","synonyms":["Biosynthesis of nicotinic acid protein 2"],"enzyme_classes":["1.13.11.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IDO","identifier":"PF01231"}],"pathways":[{"name":"NAD metabolism","kegg_map_id":null},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGAACAACACTTCCATAACCGGACCACAAGTACTACATAGAACAAAAATGAGACCACTACCAGTGCTAGAAAAATACTGTATCTCGCCACATCATGGGTTTTTGGACGACCGGTTACCCTTGACCAGACTGAGCAGCAAGAAATATATGAAATGGGAAGAAATCGTTGCTGACCTGCCCTCTCTTTTGCAAGAGGATAACAAGGTGCGGAGCGTCATCGATGGGCTGGATGTCTTGGACTTGGATGAGACGATCTTGGGCGACGTCAGGGAGCTCAGAAGAGCATATTCCATTTTGGGGTTTATGGCGCACGCTTATATTTGGGCCAGCGGAACTCCCCGGGATGTATTACCGGAGTGTATTGCAAGGCCACTGTTGGAGACAGCACATATTTTGGGTGTGCCACCGTTAGCTACGTACTCCTCGTTGGTGTTATGGAACTTCAAAGTGACCGACGAGTGCAAGAAAACGGAAACCGGGTGTTTGGACTTGGAAAATATTACAACGATAAACACATTTACGGGAACCGTTGACGAAAGTTGGTTTTATCTGGTCAGCGTGCGGTTTGAAAAAATCGGCAGCGCTTGTTTAAACCATGGGTTGCAGATATTGAGAGCCATTAGAAGCGGTGATAAAGGAGACGCTAACGTGATAGACGGGTTGGAGGGCTTGGCTGCAACGATCGAAAGGTTATCGAAAGCCTTGATGGAAATGGAGCTTAAGTGTGAACCCAATGTATTTTATTTCAAGATAAGACCATTTTTGGCCGGGTGGACGAATATGTCGCATATGGGGTTACCACAGGGTGTTAGGTATGGAGCGGAAGGACAGTATCGGATCTTTTCTGGCGGGTCCAATGCGCAAAGCTCGTTGATACAGACACTGGACATCCTTTTGGGTGTGAAACACACTGCGAATGCTGCGCATTCTTCCCAAGGAGACAGCAAGATCAATTATCTGGACGAAATGAAAAAATACATGCCAAGAGAACATCGTGAATTTCTTTACCATTTGGAATCGGTATGTAATATTCGCGAATACGTTTCTCGTAACGCTTCTAACCGTGCATTGCAAGAGGCCTATGGACGTTGCATTTCCATGCTGAAAATATTTAGAGATAACCACATTCAAATTGTTACCAAGTACATTATTTTGCCCTCCAATTCAAAGCAACACGGCTCCAATAAGCCGAACGTACTAAGTCCAATCGAGCCCAATACCAAAGCAAGTGGTTGTTTAGGGCATAAAGTTGCCTCATCTAAGACTATCGGAACCGGTGGTACAAGATTAATGCCCTTCTTAAAGCAGTGCAGGGACGAGACTGTCGCCACTGCGGACATTAAAAATGAAGATAAAAATTGA","protein_sequence":"MNNTSITGPQVLHRTKMRPLPVLEKYCISPHHGFLDDRLPLTRLSSKKYMKWEEIVADLPSLLQEDNKVRSVIDGLDVLDLDETILGDVRELRRAYSILGFMAHAYIWASGTPRDVLPECIARPLLETAHILGVPPLATYSSLVLWNFKVTDECKKTETGCLDLENITTINTFTGTVDESWFYLVSVRFEKIGSACLNHGLQILRAIRSGDKGDANVIDGLEGLAATIERLSKALMEMELKCEPNVFYFKIRPFLAGWTNMSHMGLPQGVRYGAEGQYRIFSGGSNAQSSLIQTLDILLGVKHTANAAHSSQGDSKINYLDEMKKYMPREHREFLYHLESVCNIREYVSRNASNRALQEAYGRCISMLKIFRDNHIQIVTKYIILPSNSKQHGSNKPNVLSPIEPNTKASGCLGHKVASSKTIGTGGTRLMPFLKQCRDETVATADIKNEDKN"}]}