{"ymdb_id":"YMDB00123","created_at":"2011-05-29T15:59:07.000Z","updated_at":"2016-09-08T18:35:03.000Z","name":"L-histidinol phosphate","cas":"25679-93-0","state":null,"melting_point":null,"description":"L-Histidinol phosphate is an intermediate in the biosynthesis of the amino acid histidine. [Biocyc HISTSYN-PWY]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"16996","hmdb_id":null,"kegg_id":"C01100","pubchem_id":"439398","cs_id":"388515","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"[(2S)-2-amino-3-(1H-imidazol-4-yl)propoxy]phosphonic acid","traditional_iupac":"L-histidinol phosphate","logp":"-2.9241371802886","pka":"6.733002703308064","alogps_solubility":"2.83e+01 g/l","alogps_logp":"-1.38","alogps_logs":"-0.89","acceptor_count":"5","donor_count":"4","rotatable_bond_count":"5","polar_surface_area":"121.46","refractivity":"48.498799999999996","polarizability":"19.40789171621973","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"9.668584795241904","pka_strongest_acidic":"1.5852216576798401","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["L-Histidinol phosphate","PHOSPHORIC ACID MONO-[2-AMINO-3-(3H-IMIDAZOL-4-YL)-PROPYL]ESTER"],"pathways":[{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Histidine Biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-26T17:01:53.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Histidinol-phosphate aminotransferase","uniprot_id":"P07172","uniprot_name":"HIS8_YEAST","enzyme":true,"transporter":false,"gene_name":"HIS5","num_residues":385,"molecular_weight":"42645.69922","theoretical_pi":"6.37","general_function":"Involved in transferase activity","specific_function":"L-histidinol phosphate + 2-oxoglutarate = 3- (imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate","reactions":[{"id":1632,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2458,"direction":"\u003e","locations":null,"altext":"L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":4163,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006459","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z38125","genbank_protein_id":"558690","gene_card_id":"HIS5","chromosome_location":"chromosome 9","locus":"YIL116W","synonyms":["Imidazole acetol-phosphate transaminase"],"enzyme_classes":["2.6.1.9"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" histidinol-phosphate transaminase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" histidine family amino acid metabolic process"},{"category":"Process","description":" histidine metabolic process"},{"category":"Process","description":" histidine biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Histidine Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGGTTTTTGATTTGAAAAGAATTGTTAGACCAAAAATTTATAACTTGGAACCTTATCGCTGTGCAAGAGATGATTTCACCGAGGGTATATTGCTAGACGCCAATGAAAATGCCCATGGACCTACTCCAGTTGAATTGAGCAAGACCAATTTACATCGTTACCCGGATCCTCACCAATTGGAATTCAAGACCGCAATGACGAAATACAGGAACAAAACAAGCAGTTATGCCAATGACCCAGAGGTAAAACCTTTAACTGCTGACAATCTGTGCCTAGGTGTGGGATCTGATGAGAGTATTGATGCTATTATTAGAGCATGCTGTGTTCCCGGGAAAGAAAAGATTCTGGTTCTTCCACCAACATATTCTATGTACTCTGTTTGTGCAAACATTAATGATATAGAAGTCGTCCAATGTCCTTTAACTGTTTCCGACGGTTCTTTTCAAATGGATACCGAAGCTGTATTAACCATTTTGAAAAACGACTCGCTAATTAAGTTGATGTTCGTTACTTCACCAGGTAATCCAACCGGAGCCAAAATTAAGACCAGTTTAATCGAAAAGGTCTTACAGAATTGGGACAATGGGTTAGTCGTTGTTGATGAAGCTTACGTAGATTTTTGTGGTGGCTCTACAGCTCCACTAGTCACCAAGTATCCTAACTTGGTTACTTTGCAAACTCTATCCAAGTCATTCGGTTTAGCCGGGATTAGGTTGGGTATGACATATGCAACAGCAGAGTTGGCCAGAATTTTAAATGCAATGAAGGCGCCTTATAATATTTCCTCCCTAGCCTCTGAATATGCACTAAAAGCTGTTCAAGACAGTAATCTAAAGAAGATGGAAGCCACTTCGAAAATAATCAATGAAGAGAAAATGCGCCTCTTAAAGGAATTAACTGCTTTGGATTACGTTGATGACCAATATGTTGGTGGATTAGATGCTAATTTTCTTTTAATACGGATCAACGGGGGTGACAATGTCTTGGCAAAGAAGTTATATTACCAATTGGCTACTCAATCTGGGGTTGTCGTCAGATTTAGAGGTAACGAATTAGGCTGTTCCGGATGTTTGAGAATTACCGTTGGAACCCATGAGGAGAACACACATTTGATAAAGTACTTCAAGGAGACGTTATATAAGCTGGCCAATGAATAA","protein_sequence":"MVFDLKRIVRPKIYNLEPYRCARDDFTEGILLDANENAHGPTPVELSKTNLHRYPDPHQLEFKTAMTKYRNKTSSYANDPEVKPLTADNLCLGVGSDESIDAIIRACCVPGKEKILVLPPTYSMYSVCANINDIEVVQCPLTVSDGSFQMDTEAVLTILKNDSLIKLMFVTSPGNPTGAKIKTSLIEKVLQNWDNGLVVVDEAYVDFCGGSTAPLVTKYPNLVTLQTLSKSFGLAGIRLGMTYATAELARILNAMKAPYNISSLASEYALKAVQDSNLKKMEATSKIINEEKMRLLKELTALDYVDDQYVGGLDANFLLIRINGGDNVLAKKLYYQLATQSGVVVRFRGNELGCSGCLRITVGTHEENTHLIKYFKETLYKLANE"},{"created_at":"2011-05-27T02:14:11.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Histidinol-phosphatase","uniprot_id":"P38635","uniprot_name":"HIS9_YEAST","enzyme":true,"transporter":false,"gene_name":"HIS2","num_residues":335,"molecular_weight":"38581.5","theoretical_pi":"5.81","general_function":"Involved in histidinol-phosphatase activity","specific_function":"L-histidinol phosphate + H(2)O = L-histidinol + phosphate","reactions":[{"id":1631,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2664,"direction":"\u003e","locations":"Cytoplasmic","altext":"L-histidinol phosphate + H(2)O = L-histidinol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4164,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006460","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"D50617","genbank_protein_id":"836780","gene_card_id":"HIS2","chromosome_location":"chromosome 6","locus":"YFR025C","synonyms":["HolPase"],"enzyme_classes":["3.1.3.15"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" histidinol-phosphatase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" histidine family amino acid metabolic process"},{"category":"Process","description":" histidine metabolic process"},{"category":"Process","description":" histidine biosynthetic process"}],"pfams":[{"name":"PHP","identifier":"PF02811"}],"pathways":[{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Histidine Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGCACTCACACCATTCACACTCCGGTGACTATAGTGCCCACGGTACGGACCCTTTGGATTCCGTGGTCGATCAAGTGGTCAACCTCAACTTTCACACGTACTGTTTGACAGAGCACATACCAAGAATTGAGGCCAAGTTTATATACCCCGAAGAGCAGTCATTGGGCAAGAATCCTGAGGAAGTCATAACCAAGCTAGAAACATCGTTCAAGAATTTCATGAGTCATGCGCAAGAAATCAAGACTCGTTATGCTGATAGACCCGATGTGCGGACTAAATTCATTATAGGAATGGAGATCGAAAGTTGTGACATGGCTCATATCGAATATGCAAAGCGACTCATGAAGGAGAATAATGATATTTTGAAGTTTTGTGTGGGTTCGGTCCATCACGTCAACGGGATCCCTATTGATTTCGACCAACAACAATGGTACAATTCATTGCATTCCTTCAATGATAATTTGAAACATTTTCTCCTGTCTTACTTCCAATCACAGTACGAAATGCTGATCAATATTAAACCGTTGGTCGTGGGTCACTTCGACCTTTACAAATTATTTTTGCCCAATGACATGCTAGTAAACCAGAAATCGGGCAACTGCAACGAAGAAACCGGAGTTCCTGTAGCTTCACTGGACGTCATCAGTGAATGGCCAGAAATATACGATGCAGTTGTAAGAAATTTACAATTTATAGACTCCTATGGCGGCGCAATTGAAATCAATACGTCCGCATTAAGAAAGCGCCTCGAGGAGCCGTACCCCAGCAAAACCTTATGTAATCTGGTCAAGAAGCACTGTGGATCCAGATTTGTTCTAAGTGATGACGCACACGGCGTGGCGCAAGTGGGTGTGTGCTATGACAAGGTAAAGAAATACATAGTAGACGTGCTACAATTAGAGTATATTTGCTACCTTGAGGAAAGCCAATCACCAGAGAATCTGTTAACTGTAAAGAGATTACCCATTTCGCAATTCGTTAATGATCCCTTTTGGGCCAATATATAA","protein_sequence":"MHSHHSHSGDYSAHGTDPLDSVVDQVVNLNFHTYCLTEHIPRIEAKFIYPEEQSLGKNPEEVITKLETSFKNFMSHAQEIKTRYADRPDVRTKFIIGMEIESCDMAHIEYAKRLMKENNDILKFCVGSVHHVNGIPIDFDQQQWYNSLHSFNDNLKHFLLSYFQSQYEMLINIKPLVVGHFDLYKLFLPNDMLVNQKSGNCNEETGVPVASLDVISEWPEIYDAVVRNLQFIDSYGGAIEINTSALRKRLEEPYPSKTLCNLVKKHCGSRFVLSDDAHGVAQVGVCYDKVKKYIVDVLQLEYICYLEESQSPENLLTVKRLPISQFVNDPFWANI"}]}