{"ymdb_id":"YMDB00098","created_at":"2011-05-29T15:56:30.000Z","updated_at":"2016-09-08T18:35:01.000Z","name":"Uracil","cas":"66-22-8","state":"Solid","melting_point":"330 oC","description":"Uracil is a pyrimidine nucleobase. Uracil is found in RNA and replaced with thymine in DNA. In RNA, uracil binds to adenine to assist in stabilizing the nucleic acid structures.","experimental_water_solubility":"3.6 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-1.07 [HANSCH,C ET AL. (1995)]","location":"extracellular;cytoplasm","synthesis_reference":"Burckhalter, J. H.; Scarborough, Homer C. The synthesis of uracils as anticonvulsants. Journal of the American Pharmaceutical Association (1912-1977) (1955), 44 545-50.","chebi_id":"17568","hmdb_id":"HMDB00300","kegg_id":"C00106","pubchem_id":"1174","cs_id":"1141","foodb_id":null,"wikipedia_link":"Uracil","biocyc_id":"URACIL","iupac":"1,2,3,4-tetrahydropyrimidine-2,4-dione","traditional_iupac":"uracil","logp":"-0.8552909999999998","pka":"13.756677870062841","alogps_solubility":"2.65e+01 g/l","alogps_logp":"-1.20","alogps_logs":"-0.63","acceptor_count":"2","donor_count":"2","rotatable_bond_count":"0","polar_surface_area":"58.2","refractivity":"25.9693","polarizability":"9.36551055096874","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-5.5116186106121114","pka_strongest_acidic":"8.803392786213806","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2,4-Dihydroxypyrimidine","2,4-Dioxopyrimidine","2,4-Pyrimidinediol","2,4-Pyrimidinedione","Hybar X","Pirod","Pyrod","Uracil"],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":8144575,"citation":"Volland, C., Urban-Grimal, D., Geraud, G., Haguenauer-Tsapis, R. (1994). \"Endocytosis and degradation of the yeast uracil permease under adverse conditions.\" J Biol Chem 269:9833-9841."},{"pubmed_id":1429716,"citation":"Volland, C., Garnier, C., Haguenauer-Tsapis, R. (1992). \"In vivo phosphorylation of the yeast uracil permease.\" J Biol Chem 267:23767-23771."},{"pubmed_id":10501935,"citation":"Kurtz, J. E., Exinger, F., Erbs, P., Jund, R. (1999). \"New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism.\" Curr Genet 36:130-136."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T20:49:32.000Z","updated_at":"2011-07-22T17:54:36.000Z","name":"Purine nucleoside phosphorylase","uniprot_id":"Q05788","uniprot_name":"PNPH_YEAST","enzyme":true,"transporter":false,"gene_name":"PNP1","num_residues":311,"molecular_weight":"33754.60156","theoretical_pi":"7.31","general_function":"Involved in purine-nucleoside phosphorylase activity","specific_function":"Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules","reactions":[{"id":1447,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1915,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1916,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1917,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1918,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1919,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1920,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1921,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2012,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2349,"direction":"\u003e","locations":null,"altext":"Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557950","genbank_protein_id":"45269792","gene_card_id":"PNP1","chromosome_location":"chromosome 12","locus":"YLR209C","synonyms":["PNP","Inosine phosphorylase"],"enzyme_classes":["2.4.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" purine-nucleoside phosphorylase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Process","description":" nucleoside metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"}],"pfams":[{"name":"PNP_UDP_1","identifier":"PF01048"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"}],"gene_sequence":"ATGAGTGATATCTTGAACGTAAGTCAACAACGTGAAGCAATTACCAAGGCCGCTGCGTATATTTCTGCTATTTTAGAACCACATTTCAAAAATACAACAAATTTCGAGCCTCCGAGAACTTTGATTATATGTGGTTCAGGGCTTGGTGGAATATCTACCAAGCTGTCTAGAGACAATCCACCCCCGGTAACAGTCCCATACCAAGACATCCCAGGATTCAAGAAAAGTACGGTTCCAGGTCATTCCGGTACACTAATGTTCGGATCTATGAATGGTTCACCAGTAGTATTAATGAATGGTCGTCTTCATGGATATGAAGGCAACACATTGTTTGAGACTACTTTTCCTATTAGAGTGCTTAACCACATGGGTCATGTTCGTAATTTAATTGTCACTAATGCCGCTGGTGGTATAAACGCGAAATATCAAGCCTGCGATTTGATGTGCATTTATGATCATTTAAATATCCCTGGCCTTGCTGGCCAGCACCCATTGAGAGGTCCTAACTTGGATGAAGATGGACCTCGTTTTTTAGCCTTGAGTGATGCATATGATCTGGAGTTGAGGAAGCTTTTATTTAAGAAATGGAAAGAGCTCAAGATTCAAAGGCCACTGCATGAAGGTACTTATACTTTTGTATCTGGACCCACTTTCGAAACAAGAGCAGAATCCAAAATGATAAGGATGTTGGGAGGAGATGCTGTCGGAATGAGTACTGTTCCCGAAGTCATTGTTGCAAGACATTGCGGATGGAGGGTTTTGGCCTTAAGTTTGATTACCAATACTTGCGTGGTGGATAGCCCTGCCAGTGCGTTGGACGAATCACCTGTACCCTTAGAAAAAGGCAAAGCGACTCACGCTGAAGTACTGGAGAATGGTAAAATCGCCTCTAATGACGTGCAAAACTTAATTGCTGCCGTAATGGGGGAATTATAA","protein_sequence":"MSDILNVSQQREAITKAAAYISAILEPHFKNTTNFEPPRTLIICGSGLGGISTKLSRDNPPPVTVPYQDIPGFKKSTVPGHSGTLMFGSMNGSPVVLMNGRLHGYEGNTLFETTFPIRVLNHMGHVRNLIVTNAAGGINAKYQACDLMCIYDHLNIPGLAGQHPLRGPNLDEDGPRFLALSDAYDLELRKLLFKKWKELKIQRPLHEGTYTFVSGPTFETRAESKMIRMLGGDAVGMSTVPEVIVARHCGWRVLALSLITNTCVVDSPASALDESPVPLEKGKATHAEVLENGKIASNDVQNLIAAVMGEL"},{"created_at":"2011-05-26T18:08:56.000Z","updated_at":"2011-07-22T17:54:34.000Z","name":"Cytosine deaminase","uniprot_id":"Q12178","uniprot_name":"FCY1_YEAST","enzyme":true,"transporter":false,"gene_name":"FCY1","num_residues":158,"molecular_weight":"17506.90039","theoretical_pi":"5.73","general_function":"Involved in zinc ion binding","specific_function":"Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4","reactions":[{"id":1430,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2510,"direction":"\u003e","locations":"Cytoplasmic","altext":"Cytosine + H(2)O = uracil + NH(3).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1UAQ","cellular_location":"Cytoplasmic","genbank_gene_id":"AF005261","genbank_protein_id":"2343114","gene_card_id":"FCY1","chromosome_location":"chromosome 16","locus":"YPR062W","synonyms":["Cytosine aminohydrolase"],"enzyme_classes":["3.5.4.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"dCMP_cyt_deam_1","identifier":"PF00383"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGGTGACAGGGGGAATGGCAAGCAAGTGGGATCAGAAGGGTATGGACATTGCCTATGAGGAGGCGGCCTTAGGTTACAAAGAGGGTGGTGTTCCTATTGGCGGATGTCTTATCAATAACAAAGACGGAAGTGTTCTCGGTCGTGGTCACAACATGAGATTTCAAAAGGGTTCCGCCACACTACATGGTGAGATCTCCACTTTGGAAAACTGTGGGAGATTAGAGGGCAAAGTGTACAAAGATACCACTTTGTATACGACGCTGTCTCCATGCGACATGTGTACAGGTGCCATCATCATGTATGGTATTCCACGCTGTGTTGTCGGTGAGAACGTTAATTTCAAAAGTAAGGGCGAGAAATATTTACAAACTAGAGGTCACGAGGTTGTTGTTGTTGACGATGAGAGGTGTAAAAAGATCATGAAACAATTTATCGATGAAAGACCTCAGGATTGGTTTGAAGATATTGGTGAGTAG","protein_sequence":"MVTGGMASKWDQKGMDIAYEEAALGYKEGGVPIGGCLINNKDGSVLGRGHNMRFQKGSATLHGEISTLENCGRLEGKVYKDTTLYTTLSPCDMCTGAIIMYGIPRCVVGENVNFKSKGEKYLQTRGHEVVVVDDERCKKIMKQFIDERPQDWFEDIGE"},{"created_at":"2011-05-26T19:21:47.000Z","updated_at":"2011-05-29T05:06:25.000Z","name":"tRNA pseudouridine synthase 1","uniprot_id":"Q12211","uniprot_name":"PUS1_YEAST","enzyme":true,"transporter":false,"gene_name":"PUS1","num_residues":544,"molecular_weight":"62142.0","theoretical_pi":"8.37","general_function":"Involved in RNA binding","specific_function":"Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr)","reactions":[{"id":2053,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2520,"direction":"\u003e","locations":"Cytoplasm;Nucleus. Mitochondrion;Nucleus","altext":"tRNA uridine = tRNA pseudouridine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"X80673","genbank_protein_id":"1403091","gene_card_id":"PUS1","chromosome_location":"chromosome 16","locus":"YPL212C","synonyms":["tRNA pseudouridylate synthase 1","tRNA-uridine isomerase 1"],"enzyme_classes":["5.4.99.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" pseudouridine synthase activity"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Process","description":" RNA modification"},{"category":"Process","description":" pseudouridine synthesis"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"}],"pfams":[{"name":"PseudoU_synth_1","identifier":"PF01416"}],"pathways":[],"gene_sequence":"ATGTCTGAAGAGAATTTGAGGCCTGCCTATGACGATCAAGTTAATGAGGATGTCTACAAGAGAGGCGCTCAGAGCAAATTGACCAAAGCTCGTAAGGCAGACTTCGACGATGAAAAGGACAAAAAAAAGGATAATGACAAACACATAGATAAAAGACCAAAAAGCGGTCCTCGTTTGGATGAAAATGGCAATCCACTTCCCAAGGAGCCTCGTCTCCCAAAGAGAAAGGTGGCTGTTATGGTTGGTTACTGTGGTACTGGCTACCATGGTATGCAATATAATCCACCAAATCCAACCATCGAGTCTGCCCTATTCAAAGCATTTGTTGAAGCAGGTGCTATTTCCAAGGACAACTCCAACGATTTGAAAAAGAATGGATTCATGAGAGCTGCAAGAACTGATAAGGGTGTCCATGCTGGAGGTAATTTAATATCATTGAAAATGATTATTGAAGATCCTGATATCAAGCAGAAGATCAACGAAAAGTTACCGGAAGGGATAAGGGTATGGGATATCGAGCGTGTGAACAAGGCGTTTGATTGTAGAAAAATGTGCAGTTCACGTTGGTACGAATACTTATTACCAACTTATTCACTCATTGGCCCCAAACCTGGTTCTATACTTTATAGAGACATCGAAGAAAGTAAAACAGAATTACCTGGTGTATTAGATGAAGATTTGGAATCCAAAGAATTTTGGGAAGAGTTTAAAAAAGATGCGAATGAAAAATTTTCAACAGAAGAAATCGAAGCTATATTAGCATATGTTCCGCCCGCAAGAGATGAATTTGATATAAATGAAGAACTATACCAGAAGGTAAAAAAGTACAAGCAATTAGAAAATGCTCACCGTAGAAGATATCGTATATCCGCGGCAAAACTGGCCAAATTCCGTGCTTCTACAAGTCAATACCTTGGCGCTCATAACTTCCATAATTTTACATTAGGCAAGGACTTCAAAGAACCAAGTGCCATTCGATTTATGAAAGATATAAAAGTATCTGATCCATTTGTTATTGGCGATGCCCAAACAGAATGGATTTCCATCAAGATTCACGGCCAGTCTTTCATGCTACATCAAATTCGTAAGATGGTATCAATGGCAACCTTAATTACCCGTTGTGGTTGCCCCGTCGAACGCATTAGTCAGGCTTACGGACAGCAGAAGATTAATATTCCGAAGGCACCTGCATTAGGATTATTGTTAGAAGCTCCAGTATTTGAAGGTTATAATAAAAGACTAGAACAGTTTGGTTACAAGGCGATCGATTTTTCCAAATATCAAGACGAAGTGGATAAGTTCAAAATGAAGCATATCTACGATAAGATCTACAAGGAAGAGGTGGACGAAAATGTTTTTAATGCGTTCTTTAGTTATATTGATAGTTTCAACAAGGTTACTGGAGCACAGGGAGAAGAAACTGCCGATAAATCGGGACCTGCTGTGCAAAAGAGTATCTTCGAATTCTTGACAGCTAAGGGTATCCCAGGTCTTACTGATGCGCCCGAGAGCAATAAGAAGATTAAGCAAAGAAAAAGAATGGAAGAGGAGGAAGCTGCTAGTAAAAAGGCTGAAATATCCAGCACCACTCAGAGCAACGAACCTGAAGTACAACCGGAAGCGGCAGCTAATTAG","protein_sequence":"MSEENLRPAYDDQVNEDVYKRGAQSKLTKARKADFDDEKDKKKDNDKHIDKRPKSGPRLDENGNPLPKEPRLPKRKVAVMVGYCGTGYHGMQYNPPNPTIESALFKAFVEAGAISKDNSNDLKKNGFMRAARTDKGVHAGGNLISLKMIIEDPDIKQKINEKLPEGIRVWDIERVNKAFDCRKMCSSRWYEYLLPTYSLIGPKPGSILYRDIEESKTELPGVLDEDLESKEFWEEFKKDANEKFSTEEIEAILAYVPPARDEFDINEELYQKVKKYKQLENAHRRRYRISAAKLAKFRASTSQYLGAHNFHNFTLGKDFKEPSAIRFMKDIKVSDPFVIGDAQTEWISIKIHGQSFMLHQIRKMVSMATLITRCGCPVERISQAYGQQKINIPKAPALGLLLEAPVFEGYNKRLEQFGYKAIDFSKYQDEVDKFKMKHIYDKIYKEEVDENVFNAFFSYIDSFNKVTGAQGEETADKSGPAVQKSIFEFLTAKGIPGLTDAPESNKKIKQRKRMEEEEAASKKAEISSTTQSNEPEVQPEAAAN"},{"created_at":"2011-05-26T19:22:16.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"tRNA pseudouridine synthase 4","uniprot_id":"P48567","uniprot_name":"PUS4_YEAST","enzyme":true,"transporter":false,"gene_name":"PUS4","num_residues":403,"molecular_weight":"45273.10156","theoretical_pi":"6.54","general_function":"Involved in RNA processing","specific_function":"Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs","reactions":[{"id":2053,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2520,"direction":"\u003e","locations":"Cytoplasm;Nucleus. Mitochondrion;Nucleus","altext":"tRNA uridine = tRNA pseudouridine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus. Mitochondrion","genbank_gene_id":"U23084","genbank_protein_id":"1050870","gene_card_id":"PUS4","chromosome_location":"chromosome 14","locus":"YNL292W","synonyms":["tRNA pseudouridine 55 synthase","Psi55 synthase","tRNA pseudouridylate synthase 4","tRNA-uridine isomerase 4"],"enzyme_classes":["5.4.99.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" pseudouridine synthase activity"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Process","description":" RNA modification"},{"category":"Process","description":" pseudouridine synthesis"},{"category":"Process","description":" RNA processing"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"}],"pfams":[{"name":"TruB_N","identifier":"PF01509"}],"pathways":[],"gene_sequence":"ATGAATGGAATATTTGCTATTGAGAAGCCTAGCGGTATTACATCCAATCAGTTTATGCTAAAGTTGCAACATGCTTTAACTAAAAGTCAAGTATTCTCGAAGGAAATTCAAAGGGCAACAGCGGAAAGAAAGCAGCAATATGAAAAACAGACAGGTAAGAAGGCCAGCAAGAGGAAACTTCGTAAAGTCTCAAAGGTAAAGATGGGACACGGAGGCACTTTGGATCCGTTGGCCTCTGGTGTCCTGGTAATTGGGATTGGAGCGGGCACCAAAAAACTTGCAAATTATCTTTCAGGCACCGTTAAAGTCTATGAAAGTGAAGCCCTGTTTGGTGTTTCCACTACTTCAGGAGATGTAGAAGGTGAGATTTTGTCCCAGAACTCCGTTAAACATTTAAATTTCGATGATTTAAAGACTGTGGAGGAAAAATTTGTTGGACAATTAAAGCAGACGCCGCCAATATACGCAGCTTTGAAGATGGATGGCAAACCCCTGCATGAATATGCTCGAGAAGGAAAGCCTTTACCTAGAGCCATTGAGCCCAGACAAGTTACTATTTATGACTTGAAGGTGTTTTCAGACTCTCTTAAACGTGATCATGACTATCCCTTATTGAGGCCCACTACAGAAGAAGCTGTTGATACCGTGAAAAATTTGAATGCAAACATGCTAAACGATGTTTTATACTTTTCAAAAGAATATACAGAGAAGCACGGCCTTGATTCTGAGGTGGCAAAGGTAGAAGAACCATTTCCGCTGAGTGAACAAGAAGAGCAAGAAATCCAAAAAGAAGGAGATTCTTATAGGGCTCCAAAATTGCACTTCAAAGCTAATGTGTCTTCTGGAACATACATAAGGTCCTTAGTGAGCGACATCGGTAAATCTATGAGGAGCTCATGTTATATGGTGAAATTGATACGTTTGCAACAGCAGGACTGGTCTCTTGAAAAAAATAATGTGTTCCAATTAACGGATTTTACTGAAAGAGACGAGAAGGTGTGGAGTAAGGTACTGGAGAAGGTTCTAGACGAGGGAGCAACTGTTGATGTTATAGAAGAGCTAAAGAAAGCAGAAAAGGAAATACCAGCGGACGTGAAGGAATGTATAGTTTCGAGTGATCAACCTGGTGATGAGGCTACGGCTGAAACAATTGAAACTGCTAACGCCGAAGAACATTCTAATACACTAAAAAGAAAAATCGAACAGGTGTAA","protein_sequence":"MNGIFAIEKPSGITSNQFMLKLQHALTKSQVFSKEIQRATAERKQQYEKQTGKKASKRKLRKVSKVKMGHGGTLDPLASGVLVIGIGAGTKKLANYLSGTVKVYESEALFGVSTTSGDVEGEILSQNSVKHLNFDDLKTVEEKFVGQLKQTPPIYAALKMDGKPLHEYAREGKPLPRAIEPRQVTIYDLKVFSDSLKRDHDYPLLRPTTEEAVDTVKNLNANMLNDVLYFSKEYTEKHGLDSEVAKVEEPFPLSEQEEQEIQKEGDSYRAPKLHFKANVSSGTYIRSLVSDIGKSMRSSCYMVKLIRLQQQDWSLEKNNVFQLTDFTERDEKVWSKVLEKVLDEGATVDVIEELKKAEKEIPADVKECIVSSDQPGDEATAETIETANAEEHSNTLKRKIEQV"},{"created_at":"2011-05-26T19:23:12.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Uracil permease","uniprot_id":"P05316","uniprot_name":"FUR4_YEAST","enzyme":false,"transporter":true,"gene_name":"FUR4","num_residues":633,"molecular_weight":"71735.10156","theoretical_pi":"8.0","general_function":"Involved in nucleobase transmembrane transporter activity","specific_function":"Transport of uracil","reactions":[],"signal_regions":"None","transmembrane_regions":"143-163;173-193;197-217;242-262;268-288;310-330;350-370;400-420;442-462;465-485;521-541;559-579","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"X06830","genbank_protein_id":"3706","gene_card_id":"FUR4","chromosome_location":"chromosome 2","locus":"YBR021W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" nucleobase transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Transp_cyt_pur","identifier":"PF02133"}],"pathways":[],"gene_sequence":"ATGCCAGACAATCTATCATTACATTTAAGCGGCTCTTCAAAAAGATTGAACTCTCGCCAACTTATGGAATCTTCCAATGAGACCTTTGCGCCAAATAATGTGGATTTGGAAAAAGAGTATAAGTCATCTCAGAGTAATATAACTACCGAAGTTTATGAGGCATCGAGCTTTGAAGAAAAAGTAAGCTCAGAAAAACCTCAATACAGCTCATTCTGGAAGAAAATCTATTATGAATATGTGGTCGTTGACAAATCAATCTTGGGTGTTTCTATTCTGGATTCATTTATGTACAACCAGGACTTGAAGCCCGTCGAAAAAGAAAGGCGGGTTTGGTCCTGGTACAATTATTGTTACTTCTGGCTTGCTGAATGTTTCAATATCAATACTTGGCAAATTGCAGCTACAGGTCTACAACTGGGTCTAAATTGGTGGCAGTGTTGGATAACAATTTGGATTGGGTACGGTTTCGTTGGTGCTTTTGTTGTTTTGGCCTCTAGAGTTGGATCTGCTTATCATTTGTCATTCCCTATATCATCTAGAGCATCATTCGGTATTTTCTTCTCTTTATGGCCCGTTATTAATAGAGTCGTCATGGCCATCGTTTGGTATAGTGTCCAAGCTTATATTGCGGCAACCCCCGTATCATTAATCCTGAAATCTATCTTTGGAAAAGATTTACAAGACAGAATCCCAGATCACTTTGGATCACCGAATGCTACTACTTACGAGTTCATGTGTTTTTTTATCTTTTGGGCTGCCAGTCTTCCATTTTTACTGGTCCCACCTCACAAAATTAGACACCTGTTTACTGTTAAAGCCGTCTTGGTTCCGTTTGCTTCTTTTGGTTTCTTAATTTGGGCTATCAGAAGAGCTCACGGGCGTATTGCCTTAGGATCTTTAACCGATGTACAACCTCATGGCTCTGCCTTTTCGTGGGCTTTTCTAAGATCACTAATGCGTTGTATGGCTAATTTCTCCACAATGGTAATCAACGCTCCAGATTTCTCTAGATTTTCAAAAAACCCTAACTCCGCTTTATGGTCCCAATTAGTGTGCATTCCATTTTTGTTTTCCATCACTTGTTTAATTGGAATTCTAGTCACCGCAGCTGGTTATGAAATATACGGTATTAATTACTGGTCGCCACTCGATGTGCTAGAAAAATTTTTACAGACTACTTATAATAAGGGCACAAGAGCTGGTGTTTTCTTAATCTCTTTTGTTTTCGCCGTAGCTCAGTTAGGTACTAATATTTCTGCAAACTCATTATCGTGTGGAACTGATATGTCCGCTATCTTCCCCAAGTTTATCAATATCAAGCGTGGTTCATTATTTTGTGCAGCCATGGCGCTGTGTATTTGTCCATGGAATTTAATGGCAACATCAAGTAAATTTACAATGGCTTTGTCCGCATATGCTATCTTTTTGTCCAGTATTGCCGGTGTTGTCTGCTCAGATTACTTTGTTGTTAGAAGAGGATATATCAAGCTAACACACATATATTCCCATCAAAAGGGCTCTTTTTATATGTACGGAAACAGGTTTGGTATCAATTGGAGAGCTTTGGCTGCATATCTATGTGGGGTGGCTCCTTGCTTGCCCGGTTTCATCGCGGAGGTGGGCGCTCCCGCTATAAAGGTTTCTGATGGTGCTATGAAACTATATTACCTAAGTTACTGGGTAGGATATGGCTTGAGTTTTTCTTCTTATACTGCTCTGTGTTACTTCTTCCCTGTACCTGGGTGCCCTGTTAACAACATTATAAAGGACAAGGGCTGGTTCCAAAGATGGGCCAATGTCGATGATTTTGAAGAAGAGTGGAAAGACACAATTGAGAGGGATGACCTGGTAGATGACAATATTAGTGTCTACGAACACGAACACGAAAAGACTTTCATTTAA","protein_sequence":"MPDNLSLHLSGSSKRLNSRQLMESSNETFAPNNVDLEKEYKSSQSNITTEVYEASSFEEKVSSEKPQYSSFWKKIYYEYVVVDKSILGVSILDSFMYNQDLKPVEKERRVWSWYNYCYFWLAECFNINTWQIAATGLQLGLNWWQCWITIWIGYGFVGAFVVLASRVGSAYHLSFPISSRASFGIFFSLWPVINRVVMAIVWYSVQAYIAATPVSLMLKSIFGKDLQDKIPDHFGSPNATTYEFMCFFIFWAASLPFLLVPPHKIRHLFTVKAVLVPFASFGFLIWAIRRAHGRIALGSLTDVQPHGSAFSWAFLRSLMGCMANFSTMVINAPDFSRFSKNPNSALWSQLVCIPFLFSITCLIGILVTAAGYEIYGINYWSPLDVLEKFLQTTYNKGTRAGVFLISFVFAVAQLGTNISANSLSCGTDMSAIFPKFINIKRGSLFCAAMALCICPWNLMATSSKFTMALSAYAIFLSSIAGVVCSDYFVVRRGYIKLTHIYSHQKGSFYMYGNRFGINWRALAAYLCGVAPCLPGFIAEVGAPAIKVSDGAMKLYYLSYWVGYGLSFSSYTALCYFFPVPGCPVNNIIKDKGWFQRWANVDDFEEEWKDTIERDDLVDDNISVYEHEHEKTFI"},{"created_at":"2011-05-26T19:23:54.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"tRNA pseudouridine synthase 2","uniprot_id":"P53167","uniprot_name":"PUS2_YEAST","enzyme":true,"transporter":false,"gene_name":"PUS2","num_residues":370,"molecular_weight":"41874.80078","theoretical_pi":"8.92","general_function":"Involved in RNA binding","specific_function":"Formation of pseudouridine in the anticodon stem and loop of transfer RNAs","reactions":[{"id":2053,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2520,"direction":"\u003e","locations":"Cytoplasm;Nucleus. Mitochondrion;Nucleus","altext":"tRNA uridine = tRNA pseudouridine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"X80674","genbank_protein_id":"1403093","gene_card_id":"PUS2","chromosome_location":"chromosome 7","locus":"YGL063W","synonyms":["tRNA pseudouridylate synthase 2","tRNA-uridine isomerase 2"],"enzyme_classes":["5.4.99.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" pseudouridine synthase activity"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Process","description":" RNA modification"},{"category":"Process","description":" pseudouridine synthesis"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"}],"pfams":[{"name":"PseudoU_synth_1","identifier":"PF01416"}],"pathways":[],"gene_sequence":"ATGCTCTTAGGTTACTGTGGCAGCGGATACTATGGAATGCAATACAACCCACCACACAAGACGATTGAAGGTGAGATTCTCACCAAGCTCTTCGACGTAGGAGCCATTTCCGAAGAAAATTCATTGGCACCGAAGAAAAATTCCTTTATGGCAGCGGCAAGAACAGACAAGGGTGTACACGCTATGTTGAATCTACTGTCGCTAAAGATCACATTGCGAGAGGACACAGTAGCGAAGTTAAACGCCGCACTACCGCCCGAAATACGCGTGTGGGGTATCCAGCCTGTCAATAAAAAGTTTAATGCTAGATCCGCGTGCGATTCTCGATGGTACCAATACCTTATCCCAGAATTTATACTCATTGGTCCACCCCGGAGTTCTCTTTTGCATCGAAACGTGGGGGGATGCTACCGCGAAGACGGCTCGCAAGAGGTGTGGGATACGTTCCTGGAACAGACGCGTGGGAGATTTAGCGGGGATGAGCTGTGCCGTTTGCAGGACACTGCACAGAAACTAAGCGAGAGCGATCCTTTGGTACAAGACTACGTGGGGCTATTGAGCGGTACCCTTAGCGGCTACTGCTTGTCGCCCTCGAAGCTGGACGCGTTTGAGGCAGCCATGCAGGAGTACGTGGGAACGCATAATTTTCACAACTTTACCACAGGAAAGCTTTGGGGGGATCCTAGTGCTCAGCGCCATATCAAAAAGGTTGTAGTGTCGCAGGCCTCACCGGGATGGATATGTGTGCGGATCCACGGGCAGTCGTTTATGTTGCATCAGATTCGACGAATGGTAGCGCTTGCCGTACTTGCAGCCCGTTGCCAATTGCCGCCTAATATTGTACGTAACTATTTTAACGCCGGGCCTAGGAAATACATTCCGAGGGCGCCCGCACAAGGCCTATTATTAGAGGGACCTGTGTTTGACGGGTATAACACTAAGTTGCGCAATTTGCTGTATTGCGAAATCCGCCCGGACGATATCACTCTTGAGCGCATGTGCCGTTTCCGAGAACGCCAGATCTGTACTGCGATCGCACACGAGGAGACACAGCGTCACGTGTTTTGCCATTTTGTACGACAAATGAACCGCCTGGCCACGCCTCTAATCTAG","protein_sequence":"MLLGYCGSGYYGMQYNPPHKTIEGEILTKLFDVGAISEENSLAPKKNSFMAAARTDKGVHAMLNLLSLKITLREDTVAKLNAALPPEIRVWGIQPVNKKFNARSACDSRWYQYLIPEFILIGPPRSSLLHRNVGGSYREDGSQEVWDTFLEQTRGRFSGDELCRLQDTAQKLSESDPLVQDYVGLLSGTLSGYCLSPSKLDAFEAAMQEYVGTHNFHNFTTGKLWGDPSAQRHIKKVVVSQASPGWICVRIHGQSFMLHQIRRMVALAVLAARCQLPPNIVRNYFNAGPRKYIPRAPAQGLLLEGPVFDGYNTKLRNLLYCEIRPDDITLERMCRFRERQICTAIAHEETQRHVFCHFVRQMNRLATPLI"},{"created_at":"2011-05-26T19:24:47.000Z","updated_at":"2011-05-26T19:24:47.000Z","name":"tRNA pseudouridine synthase 3","uniprot_id":"P31115","uniprot_name":"PUS3_YEAST","enzyme":true,"transporter":false,"gene_name":"PUS3","num_residues":442,"molecular_weight":"50888.30078","theoretical_pi":"9.75","general_function":"Involved in RNA binding","specific_function":"Formation of pseudouridines at positions 38 and 39 in the anticodon stem and loop of transfer RNAs","reactions":[{"id":2053,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2520,"direction":"\u003e","locations":"Cytoplasm;Nucleus. Mitochondrion;Nucleus","altext":"tRNA uridine = tRNA pseudouridine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"AY693197","genbank_protein_id":"51013845","gene_card_id":"PUS3","chromosome_location":null,"locus":null,"synonyms":["Depressed growth-rate protein DEG1","tRNA pseudouridylate synthase 3","tRNA-uridine isomerase 3"],"enzyme_classes":["5.4.99.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" pseudouridine synthase activity"},{"category":"Function","description":" RNA binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Process","description":" RNA modification"},{"category":"Process","description":" pseudouridine synthesis"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"}],"pfams":[{"name":"PseudoU_synth_1","identifier":"PF01416"}],"pathways":[],"gene_sequence":"ATGAGTAATTTCATTAGAAGGCTAGTTGGGAAAATGAAAGCGATTTCAACAGGTACCAATGCTATTGTTAGTAAGAAGGACTCCATTTACGCAAACTGGTCCAAAGAGCAGCTAATACGAAGGATCACTGAACTAGAAAACGCAAATAAGCCACATTCTGAAAAATTCCAGCACATCGAGGATAACAAAAAGCGCAAAATTTCGCAAGAAGAGGTTACGAGAAGCAAGGCGAAAAAGGCTCCGAAGAAGTTTGACTTTTCTAAACATAATACCAGGTTCATCGCCTTGAGATTTGCCTATTTGGGATGGAATTACAATGGCTTAGCTGTTCAGAAGGAATACACACCGTTGCCTACAGTAGAGGGTACCATTTTGGAGGCCATGAATAAGTGTAAACTTGTTCCCTCGATGGTTTTACAAGACTATAAATTTAGCAGATGTGGCAGAACAGACAAGGGAGTTAGCGCCATGAACCAAGTTATATCGTTAGAAGTCCGTTCCAATTTAACAGATGAGGAACAGCGGGATCCGACCAACGACAGCAGGGAAATACCCTATGTTCACGTTTTAAATCAATTACTACCCGACGATATTCGTATATCAGCTGTCTGCCTCAGACCGCCACCTAACTTTGACGCAAGATTCAGCTGTGTTCACCGGCACTATAAGTACATCTTTAATGGAAAAAACCTTAATATTGAAAAAATGTCTAAAGCCGCATCATATTTTGTTGGAGAGAGAGACTTCAGGAATTTTTGTAAGCTTGATGGCTCAAAACAAATTACCAATTTTAAACGAACAATAATAAGCTCAAAAATTCTTCCCCTTTCTGAAACTTTCTATTGTTTTGATCTCGTTGGTTCAGCATTCCTATGGCACCAAGTTCGTTGCATGATGGCCATTCTTTTCTTAGTTGGTCAATCACTTGAAGTGCCGGAAATTGTCTTGCGTCTGACTGATATTGAGAAAACCCCTCAAAGGCCTGTTTACGAAATGGCAAATGATATACCATTATTGTTATATGATTGTAAATTTCCTGAAATGGATTGGCAAGAACCTACTGTAGATGACTATAAGGCAATAAAATTCACGACAGCTACTGAAGCATTGACGTTACACTACGAACTTAAGGCCGCAGTATGCAATATTTTTAAAGATGTTTTGCCCACAGCAAATACAAACAACTTCTCAAAGACAATTATTAATTTGGGCGATGGAAGAGGTAAAGTAGTCGGTACCTATGTGAAACTAGAGGATAGAAGCGTTATGGAACCTGTCGAAGTTGTTAATGCTAAATACTCCAAGAAAAAGAACAACAAAAATAAGTAA","protein_sequence":"MSNFIRRLVGKMKAISTGTNAIVSKKDSIYANWSKEQLIRRITELENANKPHSEKFQHIEDNKKRKISQEEVTRSKAKKAPKKFDFSKHNTRFIALRFAYLGWNYNGLAVQKEYTPLPTVEGTILEAMNKCKLVPSMVLQDYKFSRCGRTDKGVSAMNQVISLEVRSNLTDEEQRDPTNDSREIPYVHVLNQLLPDDIRISAVCLRPPPNFDARFSCVHRHYKYIFNGKNLNIEKMSKAASYFVGERDFRNFCKLDGSKQITNFKRTIISSKILPLSETFYCFDLVGSAFLWHQVRCMMAILFLVGQSLEVPEIVLRLTDIEKTPQRPVYEMANDIPLLLYDCKFPEMDWQEPTVDDYKAIKFTTATEALTLHYELKAAVCNIFKDVLPTANTNNFSKTIINLGDGRGKVVGTYVKLEDRSVMEPVEVVNAKYSKKKNNKNK"},{"created_at":"2011-05-27T17:14:06.000Z","updated_at":"2011-05-29T05:06:52.000Z","name":"Uracil phosphoribosyltransferase","uniprot_id":"P18562","uniprot_name":"UPP_YEAST","enzyme":true,"transporter":false,"gene_name":"FUR1","num_residues":216,"molecular_weight":"24594.19922","theoretical_pi":"5.44","general_function":"Nucleotide transport and metabolism","specific_function":"Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate","reactions":[{"id":2034,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2834,"direction":"\u003e","locations":null,"altext":"UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"FUR1","chromosome_location":"chromosome 8","locus":"YHR128W","synonyms":["UPRTase","UMP pyrophosphorylase"],"enzyme_classes":["2.4.2.9"],"go_classes":[],"pfams":[],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGTCTTCGGAACCATTTAAGAACGTCTACTTGCTACCTCAAACAAACCAATTGCTGGGTTTGTACACCATCATCAGAAATAAGAATACAACTAGACCTGATTTCATTTTCTACTCCGATAGAATCATCAGATTGTTGGTTGAAGAAGGTTTGAACCATCTACCTGTGCAAAAGCAAATTGTGGAAACTGACACCAACGAAAACTTCGAAGGTGTCTCATTCATGGGTAAAATCTGTGGTGTTTCCATTGTCAGAGCTGGTGAATCGATGGAGCAAGGATTAAGAGACTGTTGTAGGTCTGTGCGTATCGGTAAAATTTTAATTCAAAGGGACGAGGAGACTGCTTTACCAAAGTTATTCTACGAAAAATTACCAGAGGATATATCTGAAAGGTATGTCTTCCTATTAGACCCAATGCTGGCCACCGGTGGTAGTGCTATCATGGCTACAGAAGTCTTGATTAAGAGAGGTGTTAAGCCAGAGAGAATTTACTTCTTAAACCTAATCTGTAGTAAGGAAGGGATTGAAAAATACCATGCCGCCTTCCCAGAGGTCAGAATTGTTACTGGTGCCCTCGACAGAGGTCTAGATGAAAACAAGTATCTAGTTCCAGGGTTGGGTGACTTTGGTGACAGATACTACTGTGTTTAA","protein_sequence":"MSSEPFKNVYLLPQTNQLLGLYTIIRNKNTTRPDFIFYSDRIIRLLVEEGLNHLPVQKQIVETDTNENFEGVSFMGKICGVSIVRAGESMEQGLRDCCRSVRIGKILIQRDEETALPKLFYEKLPEDISERYVFLLDPMLATGGSAIMATEVLIKRGVKPERIYFLNLICSKEGIEKYHAAFPEVRIVTGALDRGLDENKYLVPGLGDFGDRYYCV"},{"created_at":"2011-05-27T17:15:59.000Z","updated_at":"2011-07-22T17:53:59.000Z","name":"Uridine nucleosidase","uniprot_id":"Q04179","uniprot_name":"URH1_YEAST","enzyme":true,"transporter":false,"gene_name":"URH1","num_residues":340,"molecular_weight":"37960.0","theoretical_pi":"5.07","general_function":"Involved in hydrolase activity, hydrolyzing N-glycosyl compounds","specific_function":"Also acts on cytidine","reactions":[{"id":1269,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1609,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2835,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Uridine + H(2)O = D-ribose + uracil.","export":false,"pw_reaction_id":null,"source":null},{"id":4195,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006494","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"URH1","chromosome_location":"chromosome 4","locus":"YDR400W","synonyms":["Uridine ribohydrolase"],"enzyme_classes":["3.2.2.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on glycosyl bonds"},{"category":"Function","description":" hydrolase activity, hydrolyzing N-glycosyl compounds"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IU_nuc_hydro","identifier":"PF01156"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTGTTAGTAAAATACCCATATGGCTAGATTGTGATCCTGGTCATGATGATGCCATAGCCATTTTATTAGGCTGTTTCCATCCAGCTTTCAATCTTCTAGGAATCAGCACGTGTTTTGGTAACGCACCGCCAGAGAATACTGACTACAACGCCCGTTCTCTTTTGACTGCGATGGGCAAAGCACAAGCGATTCCAGTTTATAAAGGCGCACAGAGACCTTGGAAAAGGGAACCTCATTATGCTCCTGACATTCATGGTATATCAGGTTTAGACGGCACTTCTTTGCTACCTAAGCCAACATTTGAGGCAAGAACTGATAAAACGTATATTGAGGCCATTGAAGAGGCGATTCTAGCTAACAATGGAGAGATATCCTTTGTGTCTACTGGTGCACTTACCACATTAGCAACAGTTTTTAGGTGTAAACCATACCTAAAAAAATCTGTCAAATATATTAGCATTATGGGGGGTGGACTCCATGGTCTAGGAAACTGTAACCCAAATCTTTCTGCTGAATTCAACGTTTGGATTGATCCTGACGCAGCGAATTACATATTCCGTGATCCCGATGTAAAGGACAAATGTATAGTAGTTCCTCTAAATTTAACTCACAAGGCCATAGCTACTTACAAGGTTAACGAAATGATATACAACGAAAAGAATAACAGCAAGTTACGAGAATTGTTTTTGGAGCTTTTTCAATTTTTTGCTCATACCTACAAGGATATGCAAGGATTTGAATCGGGCCCACCTATACATGATCCGGTAGCTTTGATGCCGCTTTTGGAATTTTATGGGTGGGATCCATCGTCTGCGGTTGGATTTCGCTACAAGAGAATGGACATATCCTGCATTGATGATGTTTTCAACGAAAACTCAGGGAAAATTATCATTGAAAAAGAATATCCAAATGACAGTGATGTTGGTACAATAATTGGTCTCGATTTGAATATCCAGTACTTTTGGGATCAGATTTTTGAAGCATTAAATAGAGCAGACAAAATGTCAACGATTGGATAA","protein_sequence":"MTVSKIPIWLDCDPGHDDAIAILLGCFHPAFNLLGISTCFGNAPPENTDYNARSLLTAMGKAQAIPVYKGAQRPWKREPHYAPDIHGISGLDGTSLLPKPTFEARTDKTYIEAIEEAILANNGEISFVSTGALTTLATVFRCKPYLKKSVKYISIMGGGLHGLGNCNPNLSAEFNVWIDPDAANYIFRDPDVKDKCIVVPLNLTHKAIATYKVNEMIYNEKNNSKLRELFLELFQFFAHTYKDMQGFESGPPIHDPVALMPLLEFYGWDPSSAVGFRYKRMDISCIDDVFNENSGKIIIEKEYPNDSDVGTIIGLDLNIQYFWDQIFEALNRADKMSTIG"}]}