{"ymdb_id":"YMDB00096","created_at":"2011-05-29T15:56:15.000Z","updated_at":"2016-09-08T18:35:01.000Z","name":"(2R)-Homocitric acid","cas":"3562-74-1","state":"Solid","melting_point":null,"description":"(2R)-Homocitric acid is an intermediate in lysine biosynthesis pathway. S. cerevisiae synthesizes the essential amino acid L-lysine via the L-alpha-aminoadipate pathway instead of the diaminopimelate pathway. [Biocyc LYSINE-AMINOAD-PWY]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Mitochondrion, Nucleus","synthesis_reference":null,"chebi_id":"52222","hmdb_id":"HMDB03518","kegg_id":"C01251","pubchem_id":"439459","cs_id":"388564","foodb_id":null,"wikipedia_link":"Homocitrate","biocyc_id":"HOMO-CIT","iupac":"(2R)-2-hydroxybutane-1,2,4-tricarboxylic acid","traditional_iupac":"(R)-homocitric acid","logp":"-1.0340262470000003","pka":"3.9251914717112886","alogps_solubility":"1.91e+02 g/l","alogps_logp":"-1.50","alogps_logs":"-0.03","acceptor_count":"7","donor_count":"4","rotatable_bond_count":"6","polar_surface_area":"132.13","refractivity":"40.37890000000001","polarizability":"17.44345390081851","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":"-4.0751445556736625","pka_strongest_acidic":"3.086703991163821","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(R)-2-Hydroxy-1,2,4-butanetricarboxylate","(R)-2-Hydroxy-1,2,4-butanetricarboxylic acid","(R)-2-Hydroxybutane-1,2,4-tricarboxylate","(R)-2-hydroxybutane-1,2,4-tricarboxylic acid","(R)-homocitric acid","2-Hydroxybutane-1,2,4-tricarboxylate","3-Hydroxy-3-carboxyadipate","3-Hydroxy-3-carboxyadipic acid","Homocitrate","Homocitric acid"],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"lysine metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":5908136,"citation":"Maragoudakis, M. E., Strassman, M. (1966). \"Homocitric acid accumulation by a lysine-requiring yeast mutant.\" J Biol Chem 241:695-699."},{"pubmed_id":4284830,"citation":"Strassman, M., Ceci, L. N. (1965). \"Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid.\" J Biol Chem 240:4357-4361."}],"proteins":[{"created_at":"2011-05-24T21:17:39.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Homocitrate synthase, mitochondrial","uniprot_id":"Q12122","uniprot_name":"HOSM_YEAST","enzyme":true,"transporter":false,"gene_name":"LYS21","num_residues":440,"molecular_weight":"48593.80078","theoretical_pi":"6.25","general_function":"Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer","specific_function":"Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2- hydroxybutane-1,2,4-tricarboxylate + CoA","reactions":[{"id":1636,"direction":"\u003e","locations":"mitochondrion;nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2378,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion (Potential)","altext":"Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":4171,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006469","source":"Smpdb"},{"id":4172,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006567","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion (Potential)","genbank_gene_id":"X96876","genbank_protein_id":"1419231","gene_card_id":"LYS21","chromosome_location":"chromosome 4","locus":"YDL131W","synonyms":[],"enzyme_classes":["2.3.3.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"}],"pfams":[{"name":"HMGL-like","identifier":"PF00682"}],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"lysine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTGAAAATAACGAATTCCAGAGTGTCACCGAATCGACGACTGCTCCAACCACTAGTAACCCATATGGCCCAAATCCTGCGGATTATCTATCCAATGTTAAGAATTTCCAGTTGATTGATTCAACACTAAGAGAGGGTGAACAATTTGCCAACGCATTCTTCGATACTGAAAAAAAGATTGAAATTGCTAGAGCCTTGGATGATTTCGGTGTGGACTACATCGAGTTAACCTCTCCCGTAGCATCCGAACAATCAAGAAAGGACTGTGAAGCTATATGTAAACTAGGTTTAAAGGCCAAGATCCTTACACACATTCGTTGTCACATGGACGATGCCAGAGTCGCCGTAGAGACTGGTGTCGACGGTGTCGATGTTGTTATCGGCACCTCCAAATTTTTAAGACAATATTCCCACGGTAAGGATATGAACTACATCGCCAAGAGTGCTGTTGAAGTCATTGAATTTGTCAAATCCAAAGGTATTGAAATCAGATTTTCCTCTGAAGATTCCTTCAGAAGTGATCTCGTTGATCTTTTGAACATTTATAAAACCGTTGACAAGATCGGTGTAAATAGAGTCGGTATTGCCGACACAGTTGGATGTGCCAACCCAAGACAAGTATATGAACTGATCAGAACTTTGAAGAGTGTTGTCTCATGTGACATCGAATGCCATTTCCACAATGATACCGGTTGTGCCATTGCAAACGCCTACACTGCTTTGGAAGGTGGTGCCAGATTGATTGACGTCAGTGTACTGGGTATTGGTGAAAGAAACGGTATCACTCCTCTAGGTGGGCTCATGGCAAGAATGATTGTTGCCGCACCAGACTATGTCAGATCTAAATACAAGCTGCACAAGATCAGAGACATCGAAAACCTGGTCGCTGATGCTGTGGAAGTTAACATTCCATTCAACAACCCTATCACCGGGTTCTGTGCATTCACACATAAAGCAGGTATCCATGCCAAGGCCATTTTGGCTAACCCATCTACCTACGAAATCTTGGACCCTCACGATTTCGGTATGAAGAGATATATCCACTTCGCCAACAGACTAACTGGTTGGAATGCAATCAAATCAAGAGTCGACCAATTGAACTTGAATTTGACGGATGATCAAATCAAGGAAGTTACTGCTAAGATTAAGAAGCTGGGTGATGTCAGACCGCTAAATATTGATGATGTAGACTCCATTATCAAGGACTTCCATGCAGAATTGAGCACCCCACTTTTAAAACCAGTAAATAAGGGTACAGATGACGACAATATCGATATTTCCAATGGGCATGTTTCTAAAAAGGCAAAGGTCACCAAATAG","protein_sequence":"MSENNEFQSVTESTTAPTTSNPYGPNPADYLSNVKNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDARVAVETGVDGVDVVIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYVRSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKSRVDQLNLNLTDDQIKEVTAKIKKLGDVRPLNIDDVDSIIKDFHAELSTPLLKPVNKGTDDDNIDISNGHVSKKAKVTK"},{"created_at":"2011-05-24T21:51:56.000Z","updated_at":"2011-05-27T15:00:59.000Z","name":"Homocitrate synthase, cytosolic isozyme","uniprot_id":"P48570","uniprot_name":"HOSC_YEAST","enzyme":true,"transporter":false,"gene_name":"LYS20","num_residues":428,"molecular_weight":"47098.39844","theoretical_pi":"7.29","general_function":"Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer","specific_function":"Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2- hydroxybutane-1,2,4-tricarboxylate + CoA","reactions":[{"id":1636,"direction":"\u003e","locations":"mitochondrion;nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2378,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion (Potential)","altext":"Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":4173,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006470","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X83276","genbank_protein_id":"1004312","gene_card_id":"LYS20","chromosome_location":"chromosome 4","locus":"YDL182W","synonyms":[],"enzyme_classes":["2.3.3.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"}],"pfams":[{"name":"HMGL-like","identifier":"PF00682"}],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"lysine metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTGCTGCTAAACCAAATCCATATGCTGCCAAACCGGGCGACTATCTTTCTAATGTAAATAATTTCCAGTTAATCGATTCGACGCTGAGAGAAGGTGAACAATTTGCCAACGCATTCTTCGATACTGAAAAAAAGATCGAAATTGCTAGAGCCTTGGACGATTTCGGTGTGGACTACATCGAGTTAACCTCACCAGTAGCATCTGAACAATCAAGAAAGGACTGTGAAGCTATATGTAAACTAGGTTTAAAGGCCAAGATCCTTACACACATTCGTTGTCATATGGATGACGCCAAAGTCGCCGTAGAGACTGGTGTCGACGGTGTCGATGTCGTTATCGGCACCTCCAAATTTTTAAGACAATATTCCCACGGTAAGGATATGAACTACATCGCCAAGAGTGCTGTTGAAGTCATTGAATTTGTCAAATCCAAAGGTATTGAAATCAGATTTTCCTCTGAAGATTCCTTCAGAAGTGATCTCGTTGATCTTTTGAACATTTATAAAACCGTTGACAAGATCGGTGTAAATAGAGTCGGTATTGCCGACACAGTTGGATGTGCCAACCCAAGACAAGTATATGAACTGATCAGAACTTTGAAGAGTGTTGTTTCATGTGACATCGAATGCCATTTCCACAACGATACTGGTTGTGCCATTGCAAACGCCTACACTGCTTTGGAAGGTGGTGCCAGATTGATTGACGTCAGTGTACTGGGTATTGGTGAAAGAAACGGTATCACTCCTCTAGGTGGGCTCATGGCAAGAATGATTGTTGCCGCACCAGACTATGTCAAGTCCAAATACAAGTTGCACAAGATCAGAGACATTGAAAACCTGGTCGCTGATGCTGTGGAAGTTAACATTCCATTCAACAACCCTATCACCGGGTTCTGTGCATTCACACATAAAGCAGGTATCCATGCCAAGGCCATTTTGGCTAACCCATCTACCTACGAAATCTTGGACCCTCACGATTTCGGTATGAAGAGGTATATCCACTTCGCCAACAGACTAACTGGCTGGAACGCCATCAAAGCCAGAGTCGACCAGTTGAACTTGAACTTGACGGATGACCAAATCAAGGAAGTTACTGCTAAGATTAAGAAGCTGGGTGATGTCAGATCGCTGAATATCGATGATGTTGACTCTATCATCAAGAACTTCCACGCAGAGGTCAGCACTCCTCAAGTACTATCTGCAAAAAAGAACAAGAAGAATGACAGCGATGTACCGGAACTGGCCACCATCCCCGCCGCCAAGCGGACTAAGCCATCCGCCTAA","protein_sequence":"MTAAKPNPYAAKPGDYLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDAKVAVETGVDGVDVVIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQVLSAKKNKKNDSDVPELATIPAAKRTKPSA"},{"created_at":"2011-05-27T02:40:18.000Z","updated_at":"2011-07-22T17:53:43.000Z","name":"Homoaconitase, mitochondrial","uniprot_id":"P49367","uniprot_name":"LYS4_YEAST","enzyme":true,"transporter":false,"gene_name":"LYS4","num_residues":693,"molecular_weight":"75150.10156","theoretical_pi":"7.41","general_function":"Involved in metabolic process","specific_function":"Responsible for the dehydration of cis-homoaconitate to homoisocitric acid","reactions":[{"id":1150,"direction":"\u003c\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1635,"direction":"\u003c\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2684,"direction":"\u003e","locations":"Mitochondrion","altext":"(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":3708,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003288","source":"Smpdb"},{"id":3709,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003289","source":"Smpdb"},{"id":4174,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006472","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY723781","genbank_protein_id":"51830249","gene_card_id":"LYS4","chromosome_location":"chromosome 4","locus":"YDR234W","synonyms":["Homoaconitate hydratase"],"enzyme_classes":["4.2.1.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" hydro-lyase activity"},{"category":"Function","description":" 4 iron, 4 sulfur cluster binding"},{"category":"Function","description":" homoaconitate hydratase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" lysine metabolic process"},{"category":"Process","description":" lysine biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Aconitase","identifier":"PF00330"},{"name":"Aconitase_C","identifier":"PF00694"}],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"lysine metabolism","kegg_map_id":null}],"gene_sequence":"ATGCTACGATCAACCACATTTACTCGTTCGTTCCACAGTTCTAGGGCCTGGTTGAAAGGTCAGAACCTAACTGAAAAAATTGTTCAGTCGTATGCGGTCAACCTTCCCGAGGGTAAAGTTGTGCATTCTGGTGACTATGTATCGATCAAGCCGGCACACTGTATGTCCCACGATAATTCGTGGCCTGTAGCTTTGAAATTCATGGGGCTTGGCGCTACCAAGATCAAGAATCCTTCACAGATTGTGACCACTCTGGACCACGATATTCAGAACAAATCAGAGAAAAATTTGACCAAGTACAAGAACATCGAAAATTTTGCTAAGAAACACCATATAGACCACTACCCTGCCGGTAGAGGTATTGGTCATCAAATTATGATTGAGGAGGGCTATGCTTTCCCCTTGAACATGACTGTCGCATCTGACTCGCATTCAAACACCTACGGTGGTCTGGGGTCGCTGGGCACTCCAATAGTGAGAACAGACGCTGCAGCCATATGGGCCACGGGACAGACGTGGTGGCAGATCCCACCAGTGGCTCAGGTTGAGTTGAAAGGTCAATTGCCTCAGGGTGTTTCCGGAAAAGATATCATTGTCGCATTATGTGGGCTTTTCAACAATGATCAAGTTCTAAATCACGCCATTGAATTCACGGGTGACTCTTTGAATGCATTGCCTATCGATCACAGACTCACTATTGCTAACATGACCACCGAGTGGGGGGCTCTTTCTGGTTTGTTCCCCGTGGACAAAACTTTGATCGACTGGTATAAAAACCGTTTGCAAAAGCTGGGCACCAATAATCATCCAAGGATTAATCCAAAGACTATCCGCGCACTAGAAGAAAAGGCGAAGATTCCGAAAGCAGACAAGGATGCACATTATGCCAAGAAACTGATCATCGATCTAGCCACGCTAACTCACTACGTCTCAGGTCCAAATAGTGTTAAGGTCTCCAACACCGTGCAAGATCTATCTCAACAAGACATCAAGATAAATAAAGCTTATCTAGTGTCATGTACAAACTCCCGTCTATCTGATTTGCAATCTGCAGCGGATGTGGTTTGTCCTACTGGAGACTTAAACAAAGTCAACAAGGTGGCTCCAGGTGTGGAGTTCTATGTCGCTGCTGCCTCTTCAGAAATTGAGGCTGATGCCCGTAAATCAGGCGCTTGGGAAAAGCTGCTAAAGGCTGGCTGTATCCCACTGCCTTCTGGTTGTGGTCCATGCATCGGTCTAGGTGCGGGATTACTGGAACCAGGTGAAGTTGGTATCAGTGCCACAAACAGAAACTTCAAAGGTAGAATGGGTTCCAAGGATGCATTGGCTTACTTAGCTTCCCCTGCTGTAGTCGCCGCTTCTGCCGTGCTGGGTAAGATTAGTTCTCCTGCTGAGGTATTGTCCACAAGCGAAATTCCATTCAGCGGCGTTAAGACTGAGATAATTGAGAATCCCGTGGTTGAAGAGGAAGTTAACGCTCAAACAGAGGCTCCAAAACAATCCGTTGAGATATTAGAAGGTTTCCCAAGAGAGTTTTCTGGTGAATTAGTTTTATGTGATGCCGATAACATCAATACCGATGGTATATATCCTGGTAAGTACACTTATCAGGATGATGTGCCTAAAGAAAAGATGGCGCAAGTTTGTATGGAAAATTATGATGCCGAGTTCAGAACCAAGGTTCATCCAGGTGATATAGTGGTCAGTGGGTTCAATTTCGGTACCGGTTCCTCCAGGGAACGAGCGGCCACCGCCTTATTGGCTAAAGGTATCAACTTAGTTGTTTCAGGATCTTTTGGTAATATTTTTTCAAGAAACTCCATTAACAATGCTCTTCTGACCTTGGAAATCCCAGCATTAATCAAAAAATTACGTGAGAAATATCAAGGTGCTCCAAAAGAACTTACAAGAAGAACTGGTTGGTTTTTGAAATGGGATGTAGCTGATGCTAAAGTGGTCGTTACCGAAGGTTCTTTGGACGGCCCTGTGATCTTGGAGCAAAAAGTGGGTGAGCTAGGTAAGAACCTACAAGAAATTATTGTAAAAGGAGGCTTGGAAGGTTGGGTCAAATCCCAACTATAA","protein_sequence":"MLRSTTFTRSFHSSRAWLKGQNLTEKIVQSYAVNLPEGKVVHSGDYVSIKPAHCMSHDNSWPVALKFMGLGATKIKNPSQIVTTLDHDIQNKSEKNLTKYKNIENFAKKHHIDHYPAGRGIGHQIMIEEGYAFPLNMTVASDSHSNTYGGLGSLGTPIVRTDAAAIWATGQTWWQIPPVAQVELKGQLPQGVSGKDIIVALCGLFNNDQVLNHAIEFTGDSLNALPIDHRLTIANMTTEWGALSGLFPVDKTLIDWYKNRLQKLGTNNHPRINPKTIRALEEKAKIPKADKDAHYAKKLIIDLATLTHYVSGPNSVKVSNTVQDLSQQDIKINKAYLVSCTNSRLSDLQSAADVVCPTGDLNKVNKVAPGVEFYVAAASSEIEADARKSGAWEKLLKAGCIPLPSGCGPCIGLGAGLLEPGEVGISATNRNFKGRMGSKDALAYLASPAVVAASAVLGKISSPAEVLSTSEIPFSGVKTEIIENPVVEEEVNAQTEAPKQSVEILEGFPREFSGELVLCDADNINTDGIYPGKYTYQDDVPKEKMAQVCMENYDAEFRTKVHPGDIVVSGFNFGTGSSREQAATALLAKGINLVVSGSFGNIFSRNSINNALLTLEIPALIKKLREKYQGAPKELTRRTGWFLKWDVADAKVVVTEGSLDGPVILEQKVGELGKNLQEIIVKGGLEGWVKSQL"}]}